RT Journal Article SR Electronic T1 Changes in Waist Circumference and Body Mass Index in Relation to Changes in Serum Uric Acid in Japanese Individuals JF The Journal of Rheumatology JO J Rheumatol FD The Journal of Rheumatology SP 410 OP 416 DO 10.3899/jrheum.090736 VO 37 IS 2 A1 NOBUKAZU ISHIZAKA A1 YUKO ISHIZAKA A1 AKIKO TODA A1 MIZUKI TANI A1 KAZUHIKO KOIKE A1 MINORU YAMAKADO A1 RYOZO NAGAI YR 2010 UL http://www.jrheum.org/content/37/2/410.abstract AB Objective. Studies have shown that obesity is associated with an increase in serum uric acid; and few data are available on the relationship between changes in measures of obesity and changes in uric acid concentrations. We investigated the relationship among percentage changes in waist circumference (%dWC), body mass index (%dBMI), and serum uric acid (%dUA). Methods. The data of 3153 individuals [1968 men, 1185 women (536 premenopausal, 649 postmenopausal)] who underwent general health screening over a 2-year period and were not taking antihyperuricemic medication were analyzed. Results. Stepwise multiple regression analysis showed that %dBMI was associated positively with %dUA in postmenopausal women and men, and the association retained statistical significance after adjustment for changes in blood pressure and in renal function. Association between %dBMI and %dUA was not significant in premenopausal women. In men, %dWC was a predicting factor for %dUA, although it did not remain significant when %dBMI was used as a covariate in the statistical model. Multivariate logistic regression analysis showed that the odds ratio of the association between the lowest %dBMI quartile (%dBMI < –1.86) and the lowest %dUA quartile (%dUA < –7.41) was 2.04 (95% CI 1.35–3.07) in postmenopausal women and 1.46 (95% CI 1.14–1.86) in men. Conclusion. Weight loss may represent an effective nonmedical strategy for reducing serum UA levels, especially in postmenopausal women and men.