PT - JOURNAL ARTICLE AU - ILARIA PAGNINI AU - SARA SAVELLI AU - MARCO MATUCCI-CERINIC AU - CLAUDIO FONDA AU - ROLANDO CIMAZ AU - GABRIELE SIMONINI TI - Early Predictors of Juvenile Sacroiliitis in Enthesitis-related Arthritis AID - 10.3899/jrheum.100090 DP - 2010 Nov 01 TA - The Journal of Rheumatology PG - 2395--2401 VI - 37 IP - 11 4099 - http://www.jrheum.org/content/37/11/2395.short 4100 - http://www.jrheum.org/content/37/11/2395.full SO - J Rheumatol2010 Nov 01; 37 AB - Objective. To identify early predictors of sacroiliac (SI) involvement in a cohort of patients with enthesitis-related arthritis (ERA). Methods. During a 7-year followup period, all consecutive patients fulfilling the ILAR classification criteria for ERA were enrolled. Data collected included demographic, clinical and laboratory variables at disease onset, at the onset of inflammatory back pain, and at the last available followup visit. Pelvis radiographs and dynamic magnetic resonance imaging (MRI) scans for SI joints were obtained simultaneously in all patients who developed inflammatory back pain. Results. Fifty-nine children with ERA were studied; 40 male, 19 female; median age at disease onset 9 years 4 months (range 6 yrs 6 mo – 13 yrs 3 mo). At a median interval after disease onset of 1 year 3 months, 21 children reported symptoms of inflammatory back pain. In all cases, radiographs of SI joints were negative, while dynamic MRI revealed acute sacroiliitis in 17 cases. Multivariate analysis showed that the early predictors of SI were the number of active joints (p < 0.03) and the number of active entheses (p < 0.001) at onset. Conclusion. In our cohort, roughly 30% of children with ERA/juvenile idiopathic arthritis develop clinical and MRI evidence of sacroiliitis, detectable with dynamic MRI as early as 1 year after disease onset. Additional data from larger case series are needed to assess the specificity and sensitivity of this technique in the early phase of the disease and to confirm the rate of SI involvement reported in this cohort.