TY - JOUR T1 - Autologous Hematopoietic Stem Cell Transplant in Systemic Sclerosis: Quantitative High Resolution Computed Tomography of the Chest Scoring JF - The Journal of Rheumatology JO - J Rheumatol SP - 1460 LP - 1463 DO - 10.3899/jrheum.081212 VL - 36 IS - 7 AU - DAVID LAUNAY AU - ZORA MARJANOVIC AU - CEDRIC de BAZELAIRE AU - LAURA FLOREA AU - SARAH ZOHAR AU - HOMAH KESHTMAND AU - CHRISTOPHE DELIGNY AU - AXELLE de RAIGNIAC AU - ATHOL U. WELLS AU - DOMINIQUE FARGE Y1 - 2009/07/01 UR - http://www.jrheum.org/content/36/7/1460.abstract N2 - Objective. Using high resolution computed tomography (HRCT), to assess the lung involvement outcome after autologous hematopoietic stem cell transplant (AHSCT) in patients with scleroderma (systemic sclerosis, SSc). Methods. HCRT scans prospectively performed before (n = 9 patients) and after (n = 47) AHSCT were blindly reviewed by 2 independent investigators using the Wells score. Results. After a median 60 months’ followup, the overall disease extent score from HCRT scans decreased from 10 (0–45) to 4 (0–36) (p = 0.04) 6 months after AHSCT, and thereafter increased up to 36 months and stabilized; the modified Rodnan skin score fell (p < 0.05). Conclusion. The extent of SSc lung involvement on HRCT rapidly but transiently regressed after AHSCT. ER -