RT Journal Article
SR Electronic
T1 Fertility and Reproduction in Male Patients with Ankylosing Spondylitis Treated with Infliximab
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 351
OP 354
DO 10.3899/jrheum.080554
VO 36
IS 2
A1 SOPHIA PASCHOU
A1 PARASKEVI V. VOULGARI
A1 ILEANA G. VRABIE
A1 IOANNA G. SAOUGOU
A1 ALEXANDROS A. DROSOS
YR 2009
UL http://www.jrheum.org/content/36/2/351.abstract
AB Objective. To identify male patients who were treated with infliximab and had fathered healthy newborns during their management. Methods. We reviewed medical records of men with ankylosing spondylitis (AS) who were followed up at the Rheumatology Outpatients clinic and were treated with infliximab during the period 2001–2007. Results. We identified 4 patients with AS who had fathered 6 healthy children during infliximab treatment. One patient was also treated with small doses of methotrexate. Conclusion. Limited data are available concerning the effects of infliximab on semen quality. Our cases provide some evidence or reassurance for male patients treated with the anti-tumor necrosis factor-α agent. Further prospective studies are necessary, however, to guide clinicians in decisionmaking.