PT  - JOURNAL ARTICLE
AU  - SOPHIA PASCHOU
AU  - PARASKEVI V. VOULGARI
AU  - ILEANA G. VRABIE
AU  - IOANNA G. SAOUGOU
AU  - ALEXANDROS A. DROSOS
TI  - Fertility and Reproduction in Male Patients with Ankylosing Spondylitis Treated with Infliximab
AID  - 10.3899/jrheum.080554
DP  - 2009 Feb 01
TA  - The Journal of Rheumatology
PG  - 351--354
VI  - 36
IP  - 2
4099  - http://www.jrheum.org/content/36/2/351.short
4100  - http://www.jrheum.org/content/36/2/351.full
SO  - J Rheumatol2009 Feb 01; 36
AB  - Objective. To identify male patients who were treated with infliximab and had fathered healthy newborns during their management. Methods. We reviewed medical records of men with ankylosing spondylitis (AS) who were followed up at the Rheumatology Outpatients clinic and were treated with infliximab during the period 2001–2007. Results. We identified 4 patients with AS who had fathered 6 healthy children during infliximab treatment. One patient was also treated with small doses of methotrexate. Conclusion. Limited data are available concerning the effects of infliximab on semen quality. Our cases provide some evidence or reassurance for male patients treated with the anti-tumor necrosis factor-α agent. Further prospective studies are necessary, however, to guide clinicians in decisionmaking.