RT Journal Article
SR Electronic
T1 The Relationship of Estrogen Receptor-α and -β Genes with Osteoarthritis of the Hand
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 2772
OP 2779
DO 10.3899/jrheum.081208
VO 36
IS 12
A1 BARTON L. WISE
A1 SERKALEM DEMISSIE
A1 L. ADRIENNE CUPPLES
A1 DAVID T. FELSON
A1 MEI YANG
A1 AMANDA M. SHEARMAN
A1 PIRAN ALIABADI
A1 DAVID J. HUNTER
YR 2009
UL http://www.jrheum.org/content/36/12/2772.abstract
AB Objective. We examined reported associations between radiographic hand osteoarthritis (OA) and single-nucleotide polymorphisms (SNP) in 2 candidate genes associated with OA in other joints: estrogen receptor alpha (ESR1) and beta (ESR2).Methods. In 539 Framingham Offspring Study participants (49% men; mean age 61 ± 9 yrs) joint-specific radiographic hand OA was defined as Kellgren/Lawrence (K/L) scores ≥ 2 in the first carpometacarpal joint (CMC), distal interphalangeal joints (DIP), first-digit interphalangeal joint (IP), or proximal interphalangeal joints (PIP). Four SNP were genotyped for ESR1 (PvuII-rs2234693, XbaI-rs9340799, rs2077647, and rs1801132) and 4 for ESR2 (rs1256031, rs1256034, rs1256059, rs944460). Logistic regression analyses were performed to evaluate the relationships between genotypes and hand OA, adjusting for age, sex, height, and weight.Results. Radiographic hand OA was identified in at least one investigated joint of DIP (39%), PIP (33%), and first CMC (40%). There was no evidence of association between OA and genotype at any polymorphism. We found no significant association between our OA phenotypes or generalized or severe generalized OA as defined by Ushiyama and heterozygosity for rs2234693 and rs9340799, although in metaanalysis with the former study this heterozygosity remained significantly associated with generalized or severe generalized OA.Conclusion. We found no significant association between hand OA and the investigated polymorphisms of ESR1 or ESR2 despite published reports of association and a priori hypotheses implicating their potential roles. However, we could not absolutely exclude associations with rs2234693, rs9340799, or rs944460.