TY - JOUR T1 - Mannose-Binding Lectin Gene Polymorphisms Are Associated with Disease Activity and Physical Disability in Untreated, Anti-Cyclic Citrullinated Peptide-Positive Patients with Early Rheumatoid Arthritis JF - The Journal of Rheumatology JO - J Rheumatol SP - 731 LP - 735 DO - 10.3899/jrheum.080846 VL - 36 IS - 4 AU - SØREN JACOBSEN AU - PETER GARRED AU - HANS OLE MADSEN AU - NIELS H.H. HEEGAARD AU - MERETE LUND HETLAND AU - KRISTIAN STENGAARD-PEDERSEN AU - PETER JUNKER AU - TINE LOTTENBURGER AU - TORKEL ELLINGSEN AU - LIS SMEDEGAARD ANDERSEN AU - IB HANSEN AU - HENRIK SKJØDT AU - JENS KRISTIAN PEDERSEN AU - ULRIK BIRK LAURIDSEN AU - ANDERS J. SVENDSEN AU - ULRIK TARP AU - JAN PØDENPHANT AU - HANNE LINDEGAARD AU - AAGE VESTERGAARD AU - MIKKEL ØSTERGAARD AU - KIM HØRSLEV-PETERSEN Y1 - 2009/04/01 UR - http://www.jrheum.org/content/36/4/731.abstract N2 - Objective. To study the association between polymorphisms in the mannose-binding lectin gene (MBL2) and disease activity, physical disability, and joint erosions in patients with newly diagnosed rheumatoid arthritis (RA). Methods. Patients with early RA (n = 158) not previously treated with disease modifying antirheumatic drugs, participating in a treatment trial (CIMESTRA study) were examined at inclusion for MBL2 pooled structural genotypes (O/O, A/O, A/A), regulatory MBL2 promoter polymorphism in position −221 (XX, XY, YY), anti-cyclic citrullinated peptide 2 antibodies (anti-CCP2), disease activity by Disease Activity Score-28 (DAS28 score), physical disability by Health Assessment Questionnaire (HAQ) score, and erosive changes in hands and feet (Sharp-van der Heijde score). Results. Eight patients were homozygous MBL2 defective (O/O), 101 belonged to an intermediate group, and 49 were MBL2 high producers (YA/YA). Anti-CCP was present in 93 patients (59%). High scores of disease activity, C-reactive protein-based DAS28 (p = 0.02), and physical disability by HAQ (p = 0.01) were associated with high MBL2 expression genotypes in a gene-dose dependent way, but only in anti-CCP-positive patients. At this early stage of the disease there was no association with erosion score from radiographs. Conclusion. The results point to a synovitis-enhancing effect of MBL in anti-CCP-positive RA, whereas such an effect was not demonstrated for joint erosions. ER -