RT Journal Article
SR Electronic
T1 Association Between Interleukin 1 Polymorphisms and Rheumatoid Arthritis Susceptibility: A Metaanalysis
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 12
OP 15
DO 10.3899/jrheum.080450
VO 36
IS 1
A1 YOUNG HO LEE
A1 JONG DAE JI
A1 GWAN GYU SONG
YR 2009
UL http://www.jrheum.org/content/36/1/12.abstract
AB Objective. To determine whether interleukin 1 (IL-1) polymorphisms confer susceptibility to rheumatoid arthritis (RA). Methods. We conducted metaanalyses on associations between IL-1 polymorphisms and RA susceptibility, using fixed or random effects models. Results. A total of 18 separate comparisons were made using 10 European, 7 Asian, and 1 Latin American population samples. Metaanalysis of the IL-1B+3954 CC genotype revealed an association with RA in all subjects (odds ratio = 0.776, 95% confidence interval = 0.609–0.988, p = 0.040). In Asians, an association between IL-1B+3954 and RA was identified. In contrast, no association was found between the IL-1B+3954 polymorphism and RA susceptibility in European populations. Metaanalyses of the IL-1B-511 and IL-1RN VNTR polymorphisms identified no association between these polymorphisms and RA. Conclusion. Our metaanalysis shows that the IL-1B+3954 polymorphism was associated with the development of RA, but only in Asians.