RT Journal Article
SR Electronic
T1 Metabolic Syndrome Is Associated with Increased Arterial Stiffness and Biomarkers of Subclinical Atherosclerosis in Patients with Systemic Lupus Erythematosus
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 2204
OP 2211
DO 10.3899/jrheum.081253
VO 36
IS 10
A1 JOSÉ MARIO SABIO
A1 JOSÉ VARGAS-HITOS
A1 MÓNICA ZAMORA-PASADAS
A1 JUAN DIEGO MEDIAVILLA
A1 NURIA NAVARRETE
A1 ÁNGEL RAMIREZ
A1 CARMEN HIDALGO-TENORIO
A1 LAURA JÁIMEZ
A1 JAVIER MARTÍN
A1 JUAN JIMÉNEZ-ALONSO
YR 2009
UL http://www.jrheum.org/content/36/10/2204.abstract
AB Objective. Aortic pulse wave velocity (PWV) is an independent predictor of risk for atherosclerotic cardiovascular disease. Metabolic syndrome (MetS) is more prevalent in patients with systemic lupus erythematosus (SLE) compared with matched healthy subjects. Aortic PWV is increased in MetS. The purpose of this cross-sectional study was to determine the association between MetS and aortic PWV and other surrogate biomarkers of subclinical atherosclerosis in SLE. Methods. One hundred twenty-eight patients with SLE were studied. We established the presence of MetS according to the National Cholesterol Education Program Adult Treatment Panel III definition and we measured PWV, glucose, insulin, glycosylated hemoglobin (HbA1c), insulin sensitivity (HOMA index), lipid levels, uric acid, homocysteine, fibrinogen, D-dimer, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), interleukin 6 (IL-6), IL-8, IL-10, C3, C4, autoantibodies, SLE Disease Activity Index (SLEDAI), and Systemic Lupus International Collaborating Clinics/ACR Damage Index. Duration of SLE and treatment was also recorded. Multivariate logistic regression analysis was used to identify independent determinants of increased PWV. Results. SLE patients with MetS had higher aortic PWV (9.8 ± 2.4 vs 8.5 ± 1.7 m/s; p = 0.002) and increased biomarkers of subclinical atherosclerosis such as CRP, IL-6, C3, uric acid, homocysteine, fibrinogen and D-dimer, compared to those without MetS. HOMA index and insulin and HbA1c levels were also higher in this group. No differences were found in variables related to lupus activity (ESR, C4, SLEDAI, IL-8, IL-10, and treatment for SLE). In the multivariate model, increased PWV was associated with age, male sex, MetS, duration of SLE, and CRP. Conclusion. MetS may contribute to the development of accelerated atherosclerosis in SLE.