@article {IGLESIAS2144, author = {ESTIBALIZ IGLESIAS and FRANCISCO O{\textquoteright}VALLE and JUAN SALVATIERRA and JOSE ANEIROS-FERN{\'A}NDEZ and JESUS CANTERO-HINOJOSA and PEDRO HERN{\'A}NDEZ-CORT{\'E}S}, title = {Effect of Blockade of Tumor Necrosis Factor-α with Etanercept on Surgical Wound Healing in SWISS-OF1 Mice}, volume = {36}, number = {10}, pages = {2144--2148}, year = {2009}, doi = {10.3899/jrheum.081285}, publisher = {The Journal of Rheumatology}, abstract = {Objective. To assess whether blockade of tumor necrosis factor-α (TNF-α) influences surgical wound healing in a normal mouse experimental model. Methods. Wound healing time course and degree of surgical wound collagenization were measured by morphological techniques and digital image analysis in 80 male SWISS-OF1 mice (40 received subcutaneous etanercept at a dose of 0.1 mg/25g/ at -7, 0, 7, and 14 days). Results. No significant differences were observed between treated and untreated animals in wound healing, re-epithelialization, or formation of inflammatory infiltrate or granulation tissue at days 7, 15, or 20 after surgery. At 20 days, the collagen area was larger in treated versus untreated mice (109029 {\textpm} 28489 μm2 vs 79305 {\textpm} 19798 μm2, p = 0.026, Mann-Whitney U test). Conclusion. Surgical wounds showed a higher degree of collagenization at 20 days in etanercept-treated versus untreated mice, with no differences in the time course of wound healing. These data suggest that biological therapies to block TNF-α do not affect wound healing and do not need to be suspended during the perioperative period.}, issn = {0315-162X}, URL = {https://www.jrheum.org/content/36/10/2144}, eprint = {https://www.jrheum.org/content/36/10/2144.full.pdf}, journal = {The Journal of Rheumatology} }