TY - JOUR T1 - No Association Between Systemic Sclerosis and C77G Polymorphism in the Human PTPRC (CD45) Gene JF - The Journal of Rheumatology JO - J Rheumatol SP - 1817 LP - 1819 VL - 35 IS - 9 AU - HOLGER KIRSTEN AU - MECHTHILD BLUME AU - FRANK EMMRICH AU - NICO HUNZELMANN AU - RUDOLF MIERAU AU - RITA RZEPKA AU - PETER VAITH AU - TORSTEN WITTE AU - INGA MELCHERS AU - PETER AHNERT Y1 - 2008/09/01 UR - http://www.jrheum.org/content/35/9/1817.abstract N2 - Objective The functional variant C77G (rs17612648) of PTPRC (CD45) was described to confer risk for systemic sclerosis (SSc) in German Caucasians. We analyzed this association in an independent, larger German cohort. Methods We genotyped 171 cases and 179 controls. Cases were subgrouped according to sex, autoantibody profiles, or clinical subsets. Results No association of SSc with C77G was detected in the whole dataset, in subgroups, or in combined analyses with a previous study. Conclusion The results do not confirm PTPRC C77G as a general and independent risk factor for development of SSc. ER -