RT Journal Article
SR Electronic
T1 A High Interleukin 1 Receptor Antagonist/IL-1β Ratio Occurs Naturally in Knee Osteoarthritis
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 1650
OP 1654
VO 35
IS 8
A1 PASCAL RICHETTE
A1 MATHIAS FRANÇOIS
A1 ERIC VICAUT
A1 CATHERINE FITTING
A1 THOMAS BARDIN
A1 MAÏTÉ CORVOL
A1 JEAN-FRANÇOIS SAVOURET
A1 FRANÇOIS RANNOU
YR 2008
UL http://www.jrheum.org/content/35/8/1650.abstract
AB Objective To assess the interleukin 1 receptor antagonist (IL-1Ra)/IL-1β ratio in synovial fluid (SF) of patients with knee osteoarthritis (OA) or rheumatoid arthritis (RA) to determine a possible relation between cytokine level and disease activity. Methods IL-1β and IL-1Ra concentrations were measured by ELISA in knee SF from patients with OA (n = 42) or RA (n = 11). For OA patients, pain and disability were assessed by a visual analog scale (VAS) and the Lequesne index. RA disease activity was assessed using the Disease Activity Score 28 Joint Count (DAS28). Results Patients with OA showed lower median levels of IL-1β and IL-1Ra in SF than patients with RA (p < 0.001) but a higher IL-1Ra/IL-1β ratio: 1793 (584–6221) versus 773.5 (187.64–1570.5) (p = 0.05). For patients with OA, the IL-1Ra/IL-1β ratio was not associated with pain or disability. For patients with RA, the IL-1Ra/IL-1β ratio and IL-1Ra and IL-1β levels were related to SF white blood cell count. Conclusion High endogenous IL-1Ra/IL-1β ratio occurs in SF from knee OA and does not correlate with pain or Lequesne index. Our results suggest that intraarticular injection of IL-1Ra might be self-limited in patients with knee OA and a naturally high SF ratio.