RT Journal Article SR Electronic T1 Toll-like Receptor 4 and CD14 Polymorphisms in Ankylosing Spondylitis: Evidence of a Weak Association in Finns JF The Journal of Rheumatology JO J Rheumatol FD The Journal of Rheumatology SP 1609 OP 1612 VO 35 IS 8 A1 JENNIFER J. POINTON A1 KAY CHAPMAN A1 DAVID HARVEY A1 ANNE-MARIE SIMS A1 LINDA BRADBURY A1 KARI LAIHO A1 MARKKU KAUPPI A1 KALEVI KAARELA A1 JAAKKO TUOMILEHTO A1 MATTHEW A. BROWN A1 B. PAUL WORDSWORTH YR 2008 UL http://www.jrheum.org/content/35/8/1609.abstract AB Objective To investigate the association of CD14 and Toll-like receptor (TLR4) with ankylosing spondylitis (AS). Methods A promoter variant in CD14 and 2 coding polymorphisms in TLR4 were investigated in UK and Finnish families with AS and in a UK case-control study. A metaanalysis of published TLR4 and CD14 studies was performed. Results In the Finnish study the CD14-260bp T variant showed an association (p = 0.006), and the common 2-marker TLR4 haplotype showed a weak association (global p = 0.03), with AS. No associations were seen in the UK based studies or in the metaanalyses. Conclusion CD14 and TLR4 showed an association with AS in the Finns only.