RT Journal Article
SR Electronic
T1 Toll-like Receptor 4 and CD14 Polymorphisms in Ankylosing Spondylitis: Evidence of a Weak Association in Finns
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 1609
OP 1612
VO 35
IS 8
A1 JENNIFER J. POINTON
A1 KAY CHAPMAN
A1 DAVID HARVEY
A1 ANNE-MARIE SIMS
A1 LINDA BRADBURY
A1 KARI LAIHO
A1 MARKKU KAUPPI
A1 KALEVI KAARELA
A1 JAAKKO TUOMILEHTO
A1 MATTHEW A. BROWN
A1 B. PAUL WORDSWORTH
YR 2008
UL http://www.jrheum.org/content/35/8/1609.abstract
AB Objective To investigate the association of CD14 and Toll-like receptor (TLR4) with ankylosing spondylitis (AS). Methods A promoter variant in CD14 and 2 coding polymorphisms in TLR4 were investigated in UK and Finnish families with AS and in a UK case-control study. A metaanalysis of published TLR4 and CD14 studies was performed. Results In the Finnish study the CD14-260bp T variant showed an association (p = 0.006), and the common 2-marker TLR4 haplotype showed a weak association (global p = 0.03), with AS. No associations were seen in the UK based studies or in the metaanalyses. Conclusion CD14 and TLR4 showed an association with AS in the Finns only.