PT  - JOURNAL ARTICLE
AU  - JENNIFER J. POINTON
AU  - KAY CHAPMAN
AU  - DAVID HARVEY
AU  - ANNE-MARIE SIMS
AU  - LINDA BRADBURY
AU  - KARI LAIHO
AU  - MARKKU KAUPPI
AU  - KALEVI KAARELA
AU  - JAAKKO TUOMILEHTO
AU  - MATTHEW A. BROWN
AU  - B. PAUL WORDSWORTH
TI  - <em>Toll-like Receptor 4</em> and <em>CD14</em> Polymorphisms in Ankylosing Spondylitis: Evidence of a Weak Association in Finns
DP  - 2008 Aug 01
TA  - The Journal of Rheumatology
PG  - 1609--1612
VI  - 35
IP  - 8
4099  - http://www.jrheum.org/content/35/8/1609.short
4100  - http://www.jrheum.org/content/35/8/1609.full
SO  - J Rheumatol2008 Aug 01; 35
AB  - Objective To investigate the association of CD14 and Toll-like receptor (TLR4) with ankylosing spondylitis (AS). Methods A promoter variant in CD14 and 2 coding polymorphisms in TLR4 were investigated in UK and Finnish families with AS and in a UK case-control study. A metaanalysis of published TLR4 and CD14 studies was performed. Results In the Finnish study the CD14-260bp T variant showed an association (p = 0.006), and the common 2-marker TLR4 haplotype showed a weak association (global p = 0.03), with AS. No associations were seen in the UK based studies or in the metaanalyses. Conclusion CD14 and TLR4 showed an association with AS in the Finns only.