TY - JOUR T1 - A Bridge Between Interferon-α and Tumor Necrosis Factor in Lupus JF - The Journal of Rheumatology JO - J Rheumatol SP - 1473 LP - 1476 VL - 35 IS - 8 AU - MARTIN ARINGER AU - MARY K. CROW Y1 - 2008/08/01 UR - http://www.jrheum.org/content/35/8/1473.abstract N2 - In this issue of The Journal, investigators from the University of Oviedo, Spain, report novel insights on the function of antimalarials and expand their data on the influence of polymorphisms regulating tumor necrosis factor (TNF) and interleukin 10 (IL-10) expression1. The authors show that among patients with systemic lupus erythematosus (SLE) treated with antimalarials, those who express the genotype associated with low TNF and high IL-10 levels had significantly higher serum interferon-α (IFN-α) versus those with other genotypes, while those with the genotype associated with high TNF and low IL-10 levels had increased regulatory T cells. TNF and IL-10 promoter… ER -