TY - JOUR T1 - Central Nervous System Abnormalities in Fibromyalgia: Assessment Using Proton Magnetic Resonance Spectroscopy JF - The Journal of Rheumatology JO - J Rheumatol SP - 1242 LP - 1244 VL - 35 IS - 7 AU - HANI EL-GABALAWY AU - LAWRENCE RYNER Y1 - 2008/07/01 UR - http://www.jrheum.org/content/35/7/1242.abstract N2 - Fibromyalgia (FM) is a prevalent musculoskeletal disorder for which progress in developing effective diagnostics and therapeutics has been hampered by an incomplete understanding of the underlying pathophysiology. The clinical syndrome is complex and variably expressed, but almost always features some degree of pain amplification. Interestingly, this hyperalgesia is not confined to pressure stimuli, but also involves heightened responses to heat, noise, and smell, suggesting an important role for central pain processing abnormalities1. The biological basis for the clinical phenomenology seen in FM remains elusive. Studies that have attempted to shed light on the biology of FM have focused particularly on… ER -