TY - JOUR T1 - Inverse Association Between Obesity and Antinuclear Antibodies in Women JF - The Journal of Rheumatology JO - J Rheumatol SP - 2449 LP - 2451 DO - 10.3899/jrheum.080322 VL - 35 IS - 12 AU - DELIAALMEIDA GONZÁLEZ AU - ANTONIO CABRERA DE LEÓN AU - MARÍA C. RODRÍGUEZ PÉREZ AU - RAFAEL CASTRO FUENTES AU - ARMANDO AGUIRRE JAIME AU - SANTIAGO DOMÍNGUEZ COELLO AU - ANA GONZÁLEZ HERNÁNDEZ AU - BUENAVENTURA BRITO DIÁZ Y1 - 2008/12/01 UR - http://www.jrheum.org/content/35/12/2449.abstract N2 - To the Editor: More than 70% of all autoimmune illnesses occur in women, a figure that has been attributed to stimulation of the Th2 response by estrogens. However, a little-explored relationship is that which may exist between obesity and autoimmune disorders in women. Since the discovery of leptin1 it has been known that the cytokine-producing capacity of adipose tissue is high. Serum concentration of leptin is 3- to 4-fold higher in women than in men. However, little is known about the reasons for this difference. To date no studies have investigated the relationship between leptin and autoimmune disease in the… ER -