%0 Journal Article %A VIRGINIA G. KAKLAMANI %A MAUREEN SADIM %A YVONI KOUMANTAKI %A PHEDON KAKLAMANIS %A BORIS PASCHE %T Role of Polymorphisms in Adamantiades-Behçet’s Disease %D 2008 %R 10.3899/jrheum.080676 %J The Journal of Rheumatology %P 2376-2378 %V 35 %N 12 %X Objective We previously showed that Adamantiades-Behçet’s disease (A-BD) is associated with a lower incidence of malignancy compared with the general population. Transforming growth factor-β (TGF-β) has been shown to play a role in cartilage regeneration and is increased in patients with A-BD. We also found 2 functional polymorphisms of the TGF-β pathway, TGFBR1*6A and TGFB1*CC, that are associated with risk of malignancy. We tested whether incidence of these polymorphisms would differ in patients with A-BD compared with healthy controls of similar age and geographic location. Methods We performed a case-control study including 139 cases and 128 controls from Greece. Cases and controls were genotyped for TGFBR1*6A and TGFB1*CC. Results We found that cases had lower incidence of TGFBR1*6A compared with controls (11.3% vs 13.3%, respectively). Also, the incidence of TGFB1*CC was lower in cases than controls (24.6% vs 27.0%, respectively). These differences were not statistically significant. Conclusion Although there is a suggestion that the lower incidence of TGFBR1*6A in A-BD patients may play a protective role against development of malignancy, larger studies would be needed to fully evaluate the role of TGF-β and its polymorphisms in A-BD. %U https://www.jrheum.org/content/jrheum/35/12/2376.full.pdf