TY - JOUR T1 - The Interleukin 1β Pathway in the Pathogenesis of Osteoarthritis JF - The Journal of Rheumatology JO - J Rheumatol SP - 2306 LP - 2312 DO - 10.3899/jrheum.080346 VL - 35 IS - 12 AU - MASSOUD DAHESHIA AU - JIAN Q. YAO Y1 - 2008/12/01 UR - http://www.jrheum.org/content/35/12/2306.abstract N2 - Osteoarthritis (OA) is a major disabling disease and is ranked as a major cause of chronic pain in adults. The pathology of the illness is characterized by a loss of articular cartilage leading to narrowing of joint space, increased joint friction, potential structural remodeling, persistent pain, and functional impairment. The proinflammatory cytokine interleukin 1β (IL-1β) has several chemical and bioactive characteristics allowing this catabolic protein to be involved in initiation and progression of OA. We review the current understanding of the pathogenesis of OA, and how upregulation of IL-1β initiates a cascade of intracellular events that can culminate in activation… ER -