RT Journal Article
SR Electronic
T1 Cancer-associated myositis in the presence of anti-Jo1 autoantibodies and the antisynthetase syndrome.
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 169
OP 171
VO 35
IS 1
A1 Dominic Legault
A1 John McDermott
A1 Ana Maria Crous-Tsanaclis
A1 Gilles Boire
YR 2008
UL http://www.jrheum.org/content/35/1/169.abstract
AB We describe 3 patients with inflammatory myositis in association with a neoplasm whose serum also contained anti-Jo1 antibodies, one of which presented characteristic features of the antisynthetase syndrome. No patient had a rash, and muscle biopsy was suggestive of polymyositis in all 3. Immunohistochemistry confirmed the diagnosis of polymyositis in the single patient with sufficient tissue available. Our patients remind us that the presence of antisynthetase antibodies (and even antisynthetase syndrome) in a patient with inflammatory myositis does not preclude the diagnosis of cancer-associated myositis.