RT Journal Article SR Electronic T1 Different Genetic Effects of Interferon Regulatory Factor 5 (IRF5) Polymorphisms on Systemic Lupus Erythematosus in a Korean Population JF The Journal of Rheumatology JO J Rheumatol FD The Journal of Rheumatology SP 2148 OP 2151 DO 10.3899/jrheum.080124 VO 35 IS 11 A1 HYOUNG DOO SHIN A1 IL KIM A1 CHAN-BUM CHOI A1 SOO OK LEE A1 HYE WON LEE A1 SANG-CHEOL BAE YR 2008 UL http://www.jrheum.org/content/35/11/2148.abstract AB Objective In an effort to replicate additional associations of interferon regulatory factor 5 (IRF5) polymorphisms with systemic lupus erythematosus (SLE) in an Asian population, we examined those genetic effects in a Korean SLE cohort. Methods Each IRF5 polymorphism was genotyped in 1565 subjects using the TaqMan method and examined to determine whether it could explain the association with SLE. Results Three single-nucleotide polymorphisms (IRF5-15-1, rs2070197, and rs10488631), which showed strong and/or independent association in Caucasian populations, were not polymorphic in our Korean population. Association analysis revealed different genetic effects in Koreans compared with Caucasian populations. In addition, conditional analysis suggested independent genetic effects of 3 variant groups in the Korean population. Conclusion We demonstrate different genetic effects of IRF5 polymorphisms on the risk of SLE according to ethnicity.