RT Journal Article
SR Electronic
T1 Assessment of damage in Korean patients with systemic lupus erythematosus.
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 987
OP 991
VO 34
IS 5
A1 Yoon-Kyoung Sung
A1 Nam Wook Hur
A1 Jina Lee Sinskey
A1 Dawon Park
A1 Sang-Cheol Bae
YR 2007
UL http://www.jrheum.org/content/34/5/987.abstract
AB OBJECTIVE: To determine the prevalence of systemic damage in Korean patients with systemic lupus erythematosus (SLE) and to elucidate associations between possible risk factors and the presence of damage. METHODS: The Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI) was used to quantify systemic damage in 588 patients who were enrolled consecutively at the Hospital for Rheumatic Diseases, Seoul, South Korea. The frequencies and means of each variable were compared using the chi-square test or Student t test between the presence and absence of damage. Multivariate models were used to investigate the relationship between possible risk factors (age, disease duration, and use of intravenous cyclophosphamide) and the presence of damage. RESULTS: Among the 588 patients, 244 (41.5%) exhibited damage at a mean of 54 months after onset of disease. The musculoskeletal (14.3% of patients) and renal (13.3%) systems were involved most frequently, followed by neuropsychiatric (10.7%), ocular (4.6%), and pulmonary (4.1%) system involvement. The presence of damage was associated with higher age, longer disease duration, and a high frequency of intravenous cyclophosphamide use. CONCLUSION: Systemic damage in at least one of the items of the SDI was present in 41.5% of our Korean patients with SLE, this damage being significantly more prevalent in patients who were older, had longer disease duration, and received more intravenous pulses of cyclophosphamide.