PT  - JOURNAL ARTICLE
AU  - Shu-Chen Wang
AU  - Chia-Hui Lin
AU  - Tsan-Teng Ou
AU  - Cheng-Chin Wu
AU  - Wen-Chan Tsai
AU  - Chaur-Jong Hu
AU  - Hong-Wen Liu
AU  - Jeng-Hsien Yen
TI  - Ligands for programmed cell death 1 gene in patients with systemic lupus erythematosus.
DP  - 2007 Apr 01
TA  - The Journal of Rheumatology
PG  - 721--725
VI  - 34
IP  - 4
4099  - http://www.jrheum.org/content/34/4/721.short
4100  - http://www.jrheum.org/content/34/4/721.full
SO  - J Rheumatol2007 Apr 01; 34
AB  - OBJECTIVE: To investigate the role of ligands for programmed cell death 1 (PD-L) in the pathogenesis of systemic lupus erythematosus (SLE). METHODS: One hundred sixty-four patients with SLE and 160 healthy controls were enrolled in our study. The PD-L1 and PD-L2 polymorphisms were determined by polymerase chain reaction (PCR)/direct sequencing or restriction fragment length polymorphism (RFLP)-PCR. RESULTS: The genotype distributions of PD-L2 47103 C/T polymorphisms in patients with SLE were significantly different from those of the controls (p = 0.003). The genotype frequency of PD-L2 47103 T/T, in comparison with 47103 C/C, was significantly increased in patients with SLE when compared with that of the controls (odds ratio 2.5, 95% confidence interval 1.4-4.4, p = 0.001). A similar finding could also be found in the allele frequency of PD-L2 47103 T (SLE vs control, OR 1.7, 95% CI 1.3-2.4, p = 0.001). There were no significant differences in the genotype and allele frequencies of PD-L1 polymorphisms between the patients and controls. CONCLUSION: PD-L2 47103 T may be associated with susceptibility to SLE in Taiwan.