RT Journal Article
SR Electronic
T1 Influence of HLA-DRB1 genes and the shared epitope on genetic susceptibility to rheumatoid arthritis in Taiwanese.
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 674
OP 680
VO 34
IS 4
A1 Shih-Chia Liu
A1 Tzu-Yang Chang
A1 Yann-Jinn Lee
A1 Chen-Chung Chu
A1 Marie Lin
A1 Zong-Xian Chen
A1 Hsin-Fu Liu
A1 Ching-Wen Dang
A1 Shih-Chuan Chang
A1 Chyou-Shen Lee
A1 Tien-Ling Chen
A1 Chun-Hsiung Huang
YR 2007
UL http://www.jrheum.org/content/34/4/674.abstract
AB OBJECTIVE:To investigate the association of predisposing and protective HLA-DRB1 alleles with rheumatoid arthritis (RA) and its clinical markers in a Taiwanese population. METHODS: A total of 273 patients with RA and 480 healthy controls, all of Taiwanese origin, were genotyped for HLA-DRB1 alleles by polymerase chain reaction and sequence-based typing assays. The associations between RA and HLA-DRB1 alleles and genotypes were investigated by chi-squared test. RESULTS: The DRB1*0405 and *1001 phenotypes showed the most significant associations with RA (OR 4.04, 95% CI 2.84-5.77, pc = 3.2 10(-14); OR 5.25, 95% CI 2.10-13.06, pc = 3.0 10(-3), respectively). Individuals carrying single or double doses of the shared epitope (SE/non-SE or SE/SE) had higher risks of RA. The compound heterozygote of DRB1*0405/*1001 showed the largest increase in RA risk (OR 15.8, 95% CI 2.48-100.7, pc = 0.004). Single or double doses of SE alleles were significantly associated with a higher bone erosion rate. Rheumatoid factor positivity and bone erosion were more frequent in patients with at least one copy of DRB1*0405. CONCLUSION: Our results show that SE-encoding HLA-DRB1*0405 and *1001 are associated with RA in a Taiwanese population; this is the first time DRB1*1001 has been described in persons of Asian ethnicity. Heterozygotes of DRB1*0405 and *1001 predicted the strongest susceptibility to RA, suggesting that this genotype enhances susceptibility to RA in Taiwanese.