RT Journal Article SR Electronic T1 Does red-man reaction stimulate macrophage activation syndrome in children with systemic juvenile idiopathic arthritis? JF The Journal of Rheumatology JO J Rheumatol FD The Journal of Rheumatology SP 2491 OP 2494 VO 34 IS 12 A1 Seref Olgar A1 Turkan Ertugrul A1 Omer Devecioglu A1 Kemal Nisli A1 Rukiye Eker Omeroglu YR 2007 UL http://www.jrheum.org/content/34/12/2491.abstract AB Macrophage activation syndrome (MAS) is a major cause of death in patients with systemic juvenile idiopathic arthritis (JIA). We describe 4 patients who developed MAS during or after vancomycin treatment. Vancomycin should be used with great care in patients with systemic JIA.