RT Journal Article
SR Electronic
T1 Bone edema determined by magnetic resonance imaging reflects severe disease status in patients with early-stage rheumatoid arthritis.
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 2154
OP 2157
VO 34
IS 11
A1 Mami Tamai
A1 Atsushi Kawakami
A1 Masataka Uetani
A1 Shoichiro Takao
A1 Fumiko Tanaka
A1 Keita Fujikawa
A1 Toshiyuki Aramaki
A1 Hideki Nakamura
A1 Nozomi Iwanaga
A1 Yasumori Izumi
A1 Kazuhiko Arima
A1 Kouichiro Aratake
A1 Makoto Kamachi
A1 Mingguo Huang
A1 Tomoki Origuchi
A1 Hiroaki Ida
A1 Kiyoshi Aoyagi
A1 Katsumi Eguchi
YR 2007
UL http://www.jrheum.org/content/34/11/2154.abstract
AB OBJECTIVE: To determine the significance of bone edema, detected by magnetic resonance imaging (MRI), in early-stage rheumatoid arthritis (RA). METHODS: We simultaneously examined serologic variables, MRI of wrist sites and finger joints of both hands, clinical disease activity score (DAS), and HLA-DR typing at entry in 80 patients with early-stage RA. RESULTS: The number of bones scored as positive for bone edema correlated with the number of sites scored as positive for MRI synovitis and MRI bone erosion, rate of enhancement (E-rate), and serum C-reactive protein (CRP), matrix metalloproteinase 3 (MMP-3), and interleukin 6 (IL-6). Findings for MRI synovitis and MRI bone erosion, E-rate, CRP, MMP-3, IL-6, seropositivity, and titer of anti-cyclic citrullinated peptide antibody (anti-CCP antibody), DAS28-CRP and HLA-DRB1*0405 allele carriership, were significantly higher in the positive versus the negative bone edema group. CONCLUSION: Bone edema based on our scoring system may reflect severe disease status in patients with early-stage RA. However, its clinical value at entry in prognostication of RA should be examined through prospective clinical followup studies.