PT - JOURNAL ARTICLE AU - Mami Tamai AU - Atsushi Kawakami AU - Masataka Uetani AU - Shoichiro Takao AU - Fumiko Tanaka AU - Keita Fujikawa AU - Toshiyuki Aramaki AU - Hideki Nakamura AU - Nozomi Iwanaga AU - Yasumori Izumi AU - Kazuhiko Arima AU - Kouichiro Aratake AU - Makoto Kamachi AU - Mingguo Huang AU - Tomoki Origuchi AU - Hiroaki Ida AU - Kiyoshi Aoyagi AU - Katsumi Eguchi TI - Bone edema determined by magnetic resonance imaging reflects severe disease status in patients with early-stage rheumatoid arthritis. DP - 2007 Nov 01 TA - The Journal of Rheumatology PG - 2154--2157 VI - 34 IP - 11 4099 - http://www.jrheum.org/content/34/11/2154.short 4100 - http://www.jrheum.org/content/34/11/2154.full SO - J Rheumatol2007 Nov 01; 34 AB - OBJECTIVE: To determine the significance of bone edema, detected by magnetic resonance imaging (MRI), in early-stage rheumatoid arthritis (RA). METHODS: We simultaneously examined serologic variables, MRI of wrist sites and finger joints of both hands, clinical disease activity score (DAS), and HLA-DR typing at entry in 80 patients with early-stage RA. RESULTS: The number of bones scored as positive for bone edema correlated with the number of sites scored as positive for MRI synovitis and MRI bone erosion, rate of enhancement (E-rate), and serum C-reactive protein (CRP), matrix metalloproteinase 3 (MMP-3), and interleukin 6 (IL-6). Findings for MRI synovitis and MRI bone erosion, E-rate, CRP, MMP-3, IL-6, seropositivity, and titer of anti-cyclic citrullinated peptide antibody (anti-CCP antibody), DAS28-CRP and HLA-DRB1*0405 allele carriership, were significantly higher in the positive versus the negative bone edema group. CONCLUSION: Bone edema based on our scoring system may reflect severe disease status in patients with early-stage RA. However, its clinical value at entry in prognostication of RA should be examined through prospective clinical followup studies.