PT  - JOURNAL ARTICLE
AU  - Irene M Vasiliu
AU  - Michelle A Petri
AU  - Alan N Baer
TI  - Therapy with granulocyte colony-stimulating factor in systemic lupus erythematosus may be associated with severe flares.
DP  - 2006 Sep 01
TA  - The Journal of Rheumatology
PG  - 1878--1880
VI  - 33
IP  - 9
4099  - http://www.jrheum.org/content/33/9/1878.short
4100  - http://www.jrheum.org/content/33/9/1878.full
SO  - J Rheumatol2006 Sep 01; 33
AB  - OBJECTIVE: Recombinant human granulocyte colony-stimulating factor (G-CSF) has been used for treatment of febrile neutropenia in systemic lupus erythematosus (SLE) and other systemic rheumatic diseases. We describe 2 patients with SLE with disease flares with irreversible loss of renal function in association with G-CSF therapy. Eighteen patients with SLE treated with G-CSF for neutropenia have been reported, of whom 4 developed mild disease flares or cutaneous vasculitis. Our experience suggests that G-CSF therapy should be used with considerable caution in patients with SLE.