RT Journal Article
SR Electronic
T1 SLC22A4, RUNX1, and SUMO4 polymorphisms are not associated with rheumatoid arthritis: a case-control study in a Spanish population.
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 1235
OP 1239
VO 33
IS 7
A1 Gisela Orozco
A1 Elena Sánchez
A1 Miguel A González-Gay
A1 Miguel A López-Nevot
A1 Belén Torres
A1 Dora Pascual-Salcedo
A1 Alejandro Balsa
A1 Jose L Pablos
A1 Antonio García
A1 Maria Francisca González-Escribano
A1 Javier Martín
YR 2006
UL http://www.jrheum.org/content/33/7/1235.abstract
AB OBJECTIVE: To replicate the association reported in Japanese individuals of functional SLC22A4 and RUNX1 polymorphisms with rheumatoid arthritis (RA), and to test the possible role in this trait of a functional variant of the SUMO4 gene that was shown to be associated with another related autoimmune disease, type 1 diabetes (T1D). METHODS: Our study population consisted of 886 patients with RA and 987 healthy controls. All subjects were of Spanish Caucasian origin. We conducted a case-control association study with 6 single-nucleotide polymorphisms (SNP) spanning the SLC22A4 gene. SNP mapping in the RUNX1 gene associated with RA in a Japanese population and a SUMO4 polymorphism associated with T1D were also studied. RESULTS: No statistically significant differences between patients with RA and healthy controls were observed when comparing the distribution of the genotypes or alleles of any of the SLC22A4 polymorphisms tested. Similarly, no evidence of association between RA and the SLC22A4 haplotype previously reported to be associated in a Japanese population was found. With regard to the RUNX1 and SUMO4 SNP, we did not observe statistically significant differences in the distribution of genotypes or alleles between patients with RA and healthy controls. CONCLUSION: These results suggest that the SLC22A4, RUNX1, and SUMO4 polymorphisms analyzed do not confer a relevant role in susceptibility to RA in the Spanish population.