TY - JOUR T1 - Proton magnetic resonance spectroscopy reveals central neuroaxonal impairment in systemic sclerosis. JF - The Journal of Rheumatology JO - J Rheumatol SP - 546 LP - 551 VL - 33 IS - 3 AU - Luca Bertinotti AU - Marzia Mortilla AU - Maria Letizia Conforti AU - Nicola Colangelo AU - Francesca Nacci AU - Angela Del Rosso AU - Claudio Fonda AU - Roberto Casale AU - Marco Matucci-Cerinic AU - Alberto Pignone Y1 - 2006/03/01 UR - http://www.jrheum.org/content/33/3/546.abstract N2 - OBJECTIVE:. Involvement of the central nervous system (CNS) in systemic sclerosis (SSc) is rare. Proton magnetic resonance spectroscopy (1H-MRS) assesses in vivo cerebral metabolites. We investigated the biochemical modifications of the CNS in SSc. METHODS: N-acetylaspartate/creatine ratio (NAA/Cr) and choline/creatine ratio (Cho/Cr) at right centrum semiovale (RCS) and at right basal ganglia (RBG) were evaluated by 1H-MRS in 12 patients with limited (lSSc) and 8 patients with diffuse SSc (dSSc) and 20 control subjects. RESULTS: With 1H-MRS, a significant reduction of NAA/Cr ratio at RBG (p < 0.02) and at RCS (p < 0.002) was detected in SSc patients. Cho/Cr ratio was increased (p < 0.02) in the RCS, but not in RBG. In patients with lSSc, a significant reduction of NAA/Cr was detected in RCS but not in RBG. CONCLUSION: Evidence of neuroaxonal damage strongly suggests the existence of CNS involvement in SSc. ER -