Research ArticleArticle
Disease Activity Influences Cardiovascular Risk Reclassification Based on Carotid Ultrasound in Patients with Psoriatic Arthritis
Natalia Palmou-Fontana, David Martínez-Lopez, Alfonso Corrales, Javier Rueda-Gotor, Fernanda Genre, Susana Armesto, Marcos A. González-López, Juan C. Quevedo-Abeledo, Virginia Portilla-González, Ricardo Blanco, José L. Hernandez, Javier Llorca, Miguel Á. González-Gay and Iván Ferraz-Amaro
The Journal of Rheumatology November 2019, jrheum.190729; DOI: https://doi.org/10.3899/jrheum.190729
Natalia Palmou-Fontana
From the Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, Instituto de Investigación Marqués de Valdecilla (IDIVAL), Santander; Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander; Division of Rheumatology, Hospital Doctor Negrín, Las Palmas de Gran Canaria, Gran Canaria; University of Cantabria, IDIVAL, Santander; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid; School of Medicine, University of Cantabria, Santander; Division of Rheumatology, Hospital Universitario de Canarias, Tenerife, Spain; Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. Supported by a grant to Dr. Ferraz-Amaro from the Spanish Ministry of Health, Subdirección General de Evaluación y Fomento de la Investigación, Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 and by Fondo Europeo de Desarrollo Regional (FEDER; Fondo de Investigaciones Sanitarias, FIS PI14/00394, PI17/00083). Prof. González-Gay’s research was supported by European Union FEDER funds and by the “Fondo de Investigación Sanitaria” (grants PI06/0024, PS09/00748, PI12/00060, PI15/00525 and PI18/00043) of the “Instituto de Salud Carlos III” (ISCIII; Health Ministry, Spain). It was also partially supported by RETICS (health research networks) Programs RD12/0009 (RIER), RD12/0009/0013 and RD16/0012 from the “Instituto de Salud Carlos III”. N. Palmou-Fontana, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; D. Martínez-López, MD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; A. Corrales, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; J. Rueda-Gotor, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; F. Genre, PhD, Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Hospital Universitario Marqués de Valdecilla, IDIVAL; S. Armesto, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; M.A. González-López, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; J.C. Quevedo-Abeledo, MD, Division of Rheumatology, Hospital Doctor Negrín, Las Palmas de Gran Canaria; V. Portilla-González, BSc, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; R. Blanco, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; J.L. Hernández, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; J. Llorca, MD, PhD, University of Cantabria, IDIVAL, and CIBERESP, and School of Medicine, University of Cantabria; M.A. González-Gay, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, and Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Hospital Universitario Marqués de Valdecilla, IDIVAL, and School of Medicine, University of Cantabria, and Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand; I. Ferraz-Amaro, MD, PhD, Division of Rheumatology, Hospital Universitario de Canarias. Drs. M.A. González-Gay and I. Ferraz-Amaro share senior authorship. Address correspondence to Dr. I. Ferraz-Amaro, Division of Rheumatology, Hospital Universitario de Canarias, 38320 Santa Cruz de Tenerife, Spain, e-mail: iferrazamaro@hotmail.com; Dr. M.Á. González-Gay, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, e-mail: miguelaggay@hotmail.com. Accepted for publication October 24, 2019.
David Martínez-Lopez
From the Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, Instituto de Investigación Marqués de Valdecilla (IDIVAL), Santander; Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander; Division of Rheumatology, Hospital Doctor Negrín, Las Palmas de Gran Canaria, Gran Canaria; University of Cantabria, IDIVAL, Santander; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid; School of Medicine, University of Cantabria, Santander; Division of Rheumatology, Hospital Universitario de Canarias, Tenerife, Spain; Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. Supported by a grant to Dr. Ferraz-Amaro from the Spanish Ministry of Health, Subdirección General de Evaluación y Fomento de la Investigación, Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 and by Fondo Europeo de Desarrollo Regional (FEDER; Fondo de Investigaciones Sanitarias, FIS PI14/00394, PI17/00083). Prof. González-Gay’s research was supported by European Union FEDER funds and by the “Fondo de Investigación Sanitaria” (grants PI06/0024, PS09/00748, PI12/00060, PI15/00525 and PI18/00043) of the “Instituto de Salud Carlos III” (ISCIII; Health Ministry, Spain). It was also partially supported by RETICS (health research networks) Programs RD12/0009 (RIER), RD12/0009/0013 and RD16/0012 from the “Instituto de Salud Carlos III”. N. Palmou-Fontana, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; D. Martínez-López, MD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; A. Corrales, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; J. Rueda-Gotor, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; F. Genre, PhD, Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Hospital Universitario Marqués de Valdecilla, IDIVAL; S. Armesto, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; M.A. González-López, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; J.C. Quevedo-Abeledo, MD, Division of Rheumatology, Hospital Doctor Negrín, Las Palmas de Gran Canaria; V. Portilla-González, BSc, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; R. Blanco, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; J.L. Hernández, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; J. Llorca, MD, PhD, University of Cantabria, IDIVAL, and CIBERESP, and School of Medicine, University of Cantabria; M.A. González-Gay, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, and Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Hospital Universitario Marqués de Valdecilla, IDIVAL, and School of Medicine, University of Cantabria, and Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand; I. Ferraz-Amaro, MD, PhD, Division of Rheumatology, Hospital Universitario de Canarias. Drs. M.A. González-Gay and I. Ferraz-Amaro share senior authorship. Address correspondence to Dr. I. Ferraz-Amaro, Division of Rheumatology, Hospital Universitario de Canarias, 38320 Santa Cruz de Tenerife, Spain, e-mail: iferrazamaro@hotmail.com; Dr. M.Á. González-Gay, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, e-mail: miguelaggay@hotmail.com. Accepted for publication October 24, 2019.
Alfonso Corrales
From the Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, Instituto de Investigación Marqués de Valdecilla (IDIVAL), Santander; Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander; Division of Rheumatology, Hospital Doctor Negrín, Las Palmas de Gran Canaria, Gran Canaria; University of Cantabria, IDIVAL, Santander; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid; School of Medicine, University of Cantabria, Santander; Division of Rheumatology, Hospital Universitario de Canarias, Tenerife, Spain; Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. Supported by a grant to Dr. Ferraz-Amaro from the Spanish Ministry of Health, Subdirección General de Evaluación y Fomento de la Investigación, Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 and by Fondo Europeo de Desarrollo Regional (FEDER; Fondo de Investigaciones Sanitarias, FIS PI14/00394, PI17/00083). Prof. González-Gay’s research was supported by European Union FEDER funds and by the “Fondo de Investigación Sanitaria” (grants PI06/0024, PS09/00748, PI12/00060, PI15/00525 and PI18/00043) of the “Instituto de Salud Carlos III” (ISCIII; Health Ministry, Spain). It was also partially supported by RETICS (health research networks) Programs RD12/0009 (RIER), RD12/0009/0013 and RD16/0012 from the “Instituto de Salud Carlos III”. N. Palmou-Fontana, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; D. Martínez-López, MD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; A. Corrales, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; J. Rueda-Gotor, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; F. Genre, PhD, Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Hospital Universitario Marqués de Valdecilla, IDIVAL; S. Armesto, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; M.A. González-López, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; J.C. Quevedo-Abeledo, MD, Division of Rheumatology, Hospital Doctor Negrín, Las Palmas de Gran Canaria; V. Portilla-González, BSc, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; R. Blanco, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; J.L. Hernández, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; J. Llorca, MD, PhD, University of Cantabria, IDIVAL, and CIBERESP, and School of Medicine, University of Cantabria; M.A. González-Gay, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, and Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Hospital Universitario Marqués de Valdecilla, IDIVAL, and School of Medicine, University of Cantabria, and Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand; I. Ferraz-Amaro, MD, PhD, Division of Rheumatology, Hospital Universitario de Canarias. Drs. M.A. González-Gay and I. Ferraz-Amaro share senior authorship. Address correspondence to Dr. I. Ferraz-Amaro, Division of Rheumatology, Hospital Universitario de Canarias, 38320 Santa Cruz de Tenerife, Spain, e-mail: iferrazamaro@hotmail.com; Dr. M.Á. González-Gay, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, e-mail: miguelaggay@hotmail.com. Accepted for publication October 24, 2019.
Javier Rueda-Gotor
From the Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, Instituto de Investigación Marqués de Valdecilla (IDIVAL), Santander; Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander; Division of Rheumatology, Hospital Doctor Negrín, Las Palmas de Gran Canaria, Gran Canaria; University of Cantabria, IDIVAL, Santander; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid; School of Medicine, University of Cantabria, Santander; Division of Rheumatology, Hospital Universitario de Canarias, Tenerife, Spain; Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. Supported by a grant to Dr. Ferraz-Amaro from the Spanish Ministry of Health, Subdirección General de Evaluación y Fomento de la Investigación, Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 and by Fondo Europeo de Desarrollo Regional (FEDER; Fondo de Investigaciones Sanitarias, FIS PI14/00394, PI17/00083). Prof. González-Gay’s research was supported by European Union FEDER funds and by the “Fondo de Investigación Sanitaria” (grants PI06/0024, PS09/00748, PI12/00060, PI15/00525 and PI18/00043) of the “Instituto de Salud Carlos III” (ISCIII; Health Ministry, Spain). It was also partially supported by RETICS (health research networks) Programs RD12/0009 (RIER), RD12/0009/0013 and RD16/0012 from the “Instituto de Salud Carlos III”. N. Palmou-Fontana, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; D. Martínez-López, MD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; A. Corrales, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; J. Rueda-Gotor, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; F. Genre, PhD, Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Hospital Universitario Marqués de Valdecilla, IDIVAL; S. Armesto, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; M.A. González-López, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; J.C. Quevedo-Abeledo, MD, Division of Rheumatology, Hospital Doctor Negrín, Las Palmas de Gran Canaria; V. Portilla-González, BSc, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; R. Blanco, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; J.L. Hernández, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; J. Llorca, MD, PhD, University of Cantabria, IDIVAL, and CIBERESP, and School of Medicine, University of Cantabria; M.A. González-Gay, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, and Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Hospital Universitario Marqués de Valdecilla, IDIVAL, and School of Medicine, University of Cantabria, and Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand; I. Ferraz-Amaro, MD, PhD, Division of Rheumatology, Hospital Universitario de Canarias. Drs. M.A. González-Gay and I. Ferraz-Amaro share senior authorship. Address correspondence to Dr. I. Ferraz-Amaro, Division of Rheumatology, Hospital Universitario de Canarias, 38320 Santa Cruz de Tenerife, Spain, e-mail: iferrazamaro@hotmail.com; Dr. M.Á. González-Gay, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, e-mail: miguelaggay@hotmail.com. Accepted for publication October 24, 2019.
Fernanda Genre
From the Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, Instituto de Investigación Marqués de Valdecilla (IDIVAL), Santander; Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander; Division of Rheumatology, Hospital Doctor Negrín, Las Palmas de Gran Canaria, Gran Canaria; University of Cantabria, IDIVAL, Santander; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid; School of Medicine, University of Cantabria, Santander; Division of Rheumatology, Hospital Universitario de Canarias, Tenerife, Spain; Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. Supported by a grant to Dr. Ferraz-Amaro from the Spanish Ministry of Health, Subdirección General de Evaluación y Fomento de la Investigación, Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 and by Fondo Europeo de Desarrollo Regional (FEDER; Fondo de Investigaciones Sanitarias, FIS PI14/00394, PI17/00083). Prof. González-Gay’s research was supported by European Union FEDER funds and by the “Fondo de Investigación Sanitaria” (grants PI06/0024, PS09/00748, PI12/00060, PI15/00525 and PI18/00043) of the “Instituto de Salud Carlos III” (ISCIII; Health Ministry, Spain). It was also partially supported by RETICS (health research networks) Programs RD12/0009 (RIER), RD12/0009/0013 and RD16/0012 from the “Instituto de Salud Carlos III”. N. Palmou-Fontana, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; D. Martínez-López, MD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; A. Corrales, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; J. Rueda-Gotor, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; F. Genre, PhD, Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Hospital Universitario Marqués de Valdecilla, IDIVAL; S. Armesto, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; M.A. González-López, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; J.C. Quevedo-Abeledo, MD, Division of Rheumatology, Hospital Doctor Negrín, Las Palmas de Gran Canaria; V. Portilla-González, BSc, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; R. Blanco, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; J.L. Hernández, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; J. Llorca, MD, PhD, University of Cantabria, IDIVAL, and CIBERESP, and School of Medicine, University of Cantabria; M.A. González-Gay, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, and Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Hospital Universitario Marqués de Valdecilla, IDIVAL, and School of Medicine, University of Cantabria, and Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand; I. Ferraz-Amaro, MD, PhD, Division of Rheumatology, Hospital Universitario de Canarias. Drs. M.A. González-Gay and I. Ferraz-Amaro share senior authorship. Address correspondence to Dr. I. Ferraz-Amaro, Division of Rheumatology, Hospital Universitario de Canarias, 38320 Santa Cruz de Tenerife, Spain, e-mail: iferrazamaro@hotmail.com; Dr. M.Á. González-Gay, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, e-mail: miguelaggay@hotmail.com. Accepted for publication October 24, 2019.
Susana Armesto
From the Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, Instituto de Investigación Marqués de Valdecilla (IDIVAL), Santander; Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander; Division of Rheumatology, Hospital Doctor Negrín, Las Palmas de Gran Canaria, Gran Canaria; University of Cantabria, IDIVAL, Santander; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid; School of Medicine, University of Cantabria, Santander; Division of Rheumatology, Hospital Universitario de Canarias, Tenerife, Spain; Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. Supported by a grant to Dr. Ferraz-Amaro from the Spanish Ministry of Health, Subdirección General de Evaluación y Fomento de la Investigación, Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 and by Fondo Europeo de Desarrollo Regional (FEDER; Fondo de Investigaciones Sanitarias, FIS PI14/00394, PI17/00083). Prof. González-Gay’s research was supported by European Union FEDER funds and by the “Fondo de Investigación Sanitaria” (grants PI06/0024, PS09/00748, PI12/00060, PI15/00525 and PI18/00043) of the “Instituto de Salud Carlos III” (ISCIII; Health Ministry, Spain). It was also partially supported by RETICS (health research networks) Programs RD12/0009 (RIER), RD12/0009/0013 and RD16/0012 from the “Instituto de Salud Carlos III”. N. Palmou-Fontana, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; D. Martínez-López, MD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; A. Corrales, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; J. Rueda-Gotor, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; F. Genre, PhD, Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Hospital Universitario Marqués de Valdecilla, IDIVAL; S. Armesto, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; M.A. González-López, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; J.C. Quevedo-Abeledo, MD, Division of Rheumatology, Hospital Doctor Negrín, Las Palmas de Gran Canaria; V. Portilla-González, BSc, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; R. Blanco, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; J.L. Hernández, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; J. Llorca, MD, PhD, University of Cantabria, IDIVAL, and CIBERESP, and School of Medicine, University of Cantabria; M.A. González-Gay, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, and Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Hospital Universitario Marqués de Valdecilla, IDIVAL, and School of Medicine, University of Cantabria, and Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand; I. Ferraz-Amaro, MD, PhD, Division of Rheumatology, Hospital Universitario de Canarias. Drs. M.A. González-Gay and I. Ferraz-Amaro share senior authorship. Address correspondence to Dr. I. Ferraz-Amaro, Division of Rheumatology, Hospital Universitario de Canarias, 38320 Santa Cruz de Tenerife, Spain, e-mail: iferrazamaro@hotmail.com; Dr. M.Á. González-Gay, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, e-mail: miguelaggay@hotmail.com. Accepted for publication October 24, 2019.
Marcos A. González-López
From the Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, Instituto de Investigación Marqués de Valdecilla (IDIVAL), Santander; Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander; Division of Rheumatology, Hospital Doctor Negrín, Las Palmas de Gran Canaria, Gran Canaria; University of Cantabria, IDIVAL, Santander; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid; School of Medicine, University of Cantabria, Santander; Division of Rheumatology, Hospital Universitario de Canarias, Tenerife, Spain; Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. Supported by a grant to Dr. Ferraz-Amaro from the Spanish Ministry of Health, Subdirección General de Evaluación y Fomento de la Investigación, Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 and by Fondo Europeo de Desarrollo Regional (FEDER; Fondo de Investigaciones Sanitarias, FIS PI14/00394, PI17/00083). Prof. González-Gay’s research was supported by European Union FEDER funds and by the “Fondo de Investigación Sanitaria” (grants PI06/0024, PS09/00748, PI12/00060, PI15/00525 and PI18/00043) of the “Instituto de Salud Carlos III” (ISCIII; Health Ministry, Spain). It was also partially supported by RETICS (health research networks) Programs RD12/0009 (RIER), RD12/0009/0013 and RD16/0012 from the “Instituto de Salud Carlos III”. N. Palmou-Fontana, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; D. Martínez-López, MD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; A. Corrales, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; J. Rueda-Gotor, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; F. Genre, PhD, Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Hospital Universitario Marqués de Valdecilla, IDIVAL; S. Armesto, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; M.A. González-López, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; J.C. Quevedo-Abeledo, MD, Division of Rheumatology, Hospital Doctor Negrín, Las Palmas de Gran Canaria; V. Portilla-González, BSc, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; R. Blanco, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; J.L. Hernández, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; J. Llorca, MD, PhD, University of Cantabria, IDIVAL, and CIBERESP, and School of Medicine, University of Cantabria; M.A. González-Gay, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, and Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Hospital Universitario Marqués de Valdecilla, IDIVAL, and School of Medicine, University of Cantabria, and Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand; I. Ferraz-Amaro, MD, PhD, Division of Rheumatology, Hospital Universitario de Canarias. Drs. M.A. González-Gay and I. Ferraz-Amaro share senior authorship. Address correspondence to Dr. I. Ferraz-Amaro, Division of Rheumatology, Hospital Universitario de Canarias, 38320 Santa Cruz de Tenerife, Spain, e-mail: iferrazamaro@hotmail.com; Dr. M.Á. González-Gay, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, e-mail: miguelaggay@hotmail.com. Accepted for publication October 24, 2019.
Juan C. Quevedo-Abeledo
From the Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, Instituto de Investigación Marqués de Valdecilla (IDIVAL), Santander; Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander; Division of Rheumatology, Hospital Doctor Negrín, Las Palmas de Gran Canaria, Gran Canaria; University of Cantabria, IDIVAL, Santander; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid; School of Medicine, University of Cantabria, Santander; Division of Rheumatology, Hospital Universitario de Canarias, Tenerife, Spain; Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. Supported by a grant to Dr. Ferraz-Amaro from the Spanish Ministry of Health, Subdirección General de Evaluación y Fomento de la Investigación, Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 and by Fondo Europeo de Desarrollo Regional (FEDER; Fondo de Investigaciones Sanitarias, FIS PI14/00394, PI17/00083). Prof. González-Gay’s research was supported by European Union FEDER funds and by the “Fondo de Investigación Sanitaria” (grants PI06/0024, PS09/00748, PI12/00060, PI15/00525 and PI18/00043) of the “Instituto de Salud Carlos III” (ISCIII; Health Ministry, Spain). It was also partially supported by RETICS (health research networks) Programs RD12/0009 (RIER), RD12/0009/0013 and RD16/0012 from the “Instituto de Salud Carlos III”. N. Palmou-Fontana, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; D. Martínez-López, MD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; A. Corrales, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; J. Rueda-Gotor, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; F. Genre, PhD, Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Hospital Universitario Marqués de Valdecilla, IDIVAL; S. Armesto, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; M.A. González-López, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; J.C. Quevedo-Abeledo, MD, Division of Rheumatology, Hospital Doctor Negrín, Las Palmas de Gran Canaria; V. Portilla-González, BSc, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; R. Blanco, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; J.L. Hernández, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; J. Llorca, MD, PhD, University of Cantabria, IDIVAL, and CIBERESP, and School of Medicine, University of Cantabria; M.A. González-Gay, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, and Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Hospital Universitario Marqués de Valdecilla, IDIVAL, and School of Medicine, University of Cantabria, and Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand; I. Ferraz-Amaro, MD, PhD, Division of Rheumatology, Hospital Universitario de Canarias. Drs. M.A. González-Gay and I. Ferraz-Amaro share senior authorship. Address correspondence to Dr. I. Ferraz-Amaro, Division of Rheumatology, Hospital Universitario de Canarias, 38320 Santa Cruz de Tenerife, Spain, e-mail: iferrazamaro@hotmail.com; Dr. M.Á. González-Gay, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, e-mail: miguelaggay@hotmail.com. Accepted for publication October 24, 2019.
Virginia Portilla-González
From the Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, Instituto de Investigación Marqués de Valdecilla (IDIVAL), Santander; Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander; Division of Rheumatology, Hospital Doctor Negrín, Las Palmas de Gran Canaria, Gran Canaria; University of Cantabria, IDIVAL, Santander; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid; School of Medicine, University of Cantabria, Santander; Division of Rheumatology, Hospital Universitario de Canarias, Tenerife, Spain; Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. Supported by a grant to Dr. Ferraz-Amaro from the Spanish Ministry of Health, Subdirección General de Evaluación y Fomento de la Investigación, Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 and by Fondo Europeo de Desarrollo Regional (FEDER; Fondo de Investigaciones Sanitarias, FIS PI14/00394, PI17/00083). Prof. González-Gay’s research was supported by European Union FEDER funds and by the “Fondo de Investigación Sanitaria” (grants PI06/0024, PS09/00748, PI12/00060, PI15/00525 and PI18/00043) of the “Instituto de Salud Carlos III” (ISCIII; Health Ministry, Spain). It was also partially supported by RETICS (health research networks) Programs RD12/0009 (RIER), RD12/0009/0013 and RD16/0012 from the “Instituto de Salud Carlos III”. N. Palmou-Fontana, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; D. Martínez-López, MD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; A. Corrales, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; J. Rueda-Gotor, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; F. Genre, PhD, Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Hospital Universitario Marqués de Valdecilla, IDIVAL; S. Armesto, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; M.A. González-López, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; J.C. Quevedo-Abeledo, MD, Division of Rheumatology, Hospital Doctor Negrín, Las Palmas de Gran Canaria; V. Portilla-González, BSc, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; R. Blanco, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; J.L. Hernández, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; J. Llorca, MD, PhD, University of Cantabria, IDIVAL, and CIBERESP, and School of Medicine, University of Cantabria; M.A. González-Gay, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, and Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Hospital Universitario Marqués de Valdecilla, IDIVAL, and School of Medicine, University of Cantabria, and Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand; I. Ferraz-Amaro, MD, PhD, Division of Rheumatology, Hospital Universitario de Canarias. Drs. M.A. González-Gay and I. Ferraz-Amaro share senior authorship. Address correspondence to Dr. I. Ferraz-Amaro, Division of Rheumatology, Hospital Universitario de Canarias, 38320 Santa Cruz de Tenerife, Spain, e-mail: iferrazamaro@hotmail.com; Dr. M.Á. González-Gay, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, e-mail: miguelaggay@hotmail.com. Accepted for publication October 24, 2019.
Ricardo Blanco
From the Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, Instituto de Investigación Marqués de Valdecilla (IDIVAL), Santander; Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander; Division of Rheumatology, Hospital Doctor Negrín, Las Palmas de Gran Canaria, Gran Canaria; University of Cantabria, IDIVAL, Santander; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid; School of Medicine, University of Cantabria, Santander; Division of Rheumatology, Hospital Universitario de Canarias, Tenerife, Spain; Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. Supported by a grant to Dr. Ferraz-Amaro from the Spanish Ministry of Health, Subdirección General de Evaluación y Fomento de la Investigación, Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 and by Fondo Europeo de Desarrollo Regional (FEDER; Fondo de Investigaciones Sanitarias, FIS PI14/00394, PI17/00083). Prof. González-Gay’s research was supported by European Union FEDER funds and by the “Fondo de Investigación Sanitaria” (grants PI06/0024, PS09/00748, PI12/00060, PI15/00525 and PI18/00043) of the “Instituto de Salud Carlos III” (ISCIII; Health Ministry, Spain). It was also partially supported by RETICS (health research networks) Programs RD12/0009 (RIER), RD12/0009/0013 and RD16/0012 from the “Instituto de Salud Carlos III”. N. Palmou-Fontana, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; D. Martínez-López, MD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; A. Corrales, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; J. Rueda-Gotor, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; F. Genre, PhD, Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Hospital Universitario Marqués de Valdecilla, IDIVAL; S. Armesto, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; M.A. González-López, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; J.C. Quevedo-Abeledo, MD, Division of Rheumatology, Hospital Doctor Negrín, Las Palmas de Gran Canaria; V. Portilla-González, BSc, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; R. Blanco, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; J.L. Hernández, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; J. Llorca, MD, PhD, University of Cantabria, IDIVAL, and CIBERESP, and School of Medicine, University of Cantabria; M.A. González-Gay, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, and Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Hospital Universitario Marqués de Valdecilla, IDIVAL, and School of Medicine, University of Cantabria, and Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand; I. Ferraz-Amaro, MD, PhD, Division of Rheumatology, Hospital Universitario de Canarias. Drs. M.A. González-Gay and I. Ferraz-Amaro share senior authorship. Address correspondence to Dr. I. Ferraz-Amaro, Division of Rheumatology, Hospital Universitario de Canarias, 38320 Santa Cruz de Tenerife, Spain, e-mail: iferrazamaro@hotmail.com; Dr. M.Á. González-Gay, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, e-mail: miguelaggay@hotmail.com. Accepted for publication October 24, 2019.
José L. Hernandez
From the Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, Instituto de Investigación Marqués de Valdecilla (IDIVAL), Santander; Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander; Division of Rheumatology, Hospital Doctor Negrín, Las Palmas de Gran Canaria, Gran Canaria; University of Cantabria, IDIVAL, Santander; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid; School of Medicine, University of Cantabria, Santander; Division of Rheumatology, Hospital Universitario de Canarias, Tenerife, Spain; Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. Supported by a grant to Dr. Ferraz-Amaro from the Spanish Ministry of Health, Subdirección General de Evaluación y Fomento de la Investigación, Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 and by Fondo Europeo de Desarrollo Regional (FEDER; Fondo de Investigaciones Sanitarias, FIS PI14/00394, PI17/00083). Prof. González-Gay’s research was supported by European Union FEDER funds and by the “Fondo de Investigación Sanitaria” (grants PI06/0024, PS09/00748, PI12/00060, PI15/00525 and PI18/00043) of the “Instituto de Salud Carlos III” (ISCIII; Health Ministry, Spain). It was also partially supported by RETICS (health research networks) Programs RD12/0009 (RIER), RD12/0009/0013 and RD16/0012 from the “Instituto de Salud Carlos III”. N. Palmou-Fontana, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; D. Martínez-López, MD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; A. Corrales, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; J. Rueda-Gotor, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; F. Genre, PhD, Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Hospital Universitario Marqués de Valdecilla, IDIVAL; S. Armesto, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; M.A. González-López, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; J.C. Quevedo-Abeledo, MD, Division of Rheumatology, Hospital Doctor Negrín, Las Palmas de Gran Canaria; V. Portilla-González, BSc, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; R. Blanco, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; J.L. Hernández, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; J. Llorca, MD, PhD, University of Cantabria, IDIVAL, and CIBERESP, and School of Medicine, University of Cantabria; M.A. González-Gay, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, and Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Hospital Universitario Marqués de Valdecilla, IDIVAL, and School of Medicine, University of Cantabria, and Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand; I. Ferraz-Amaro, MD, PhD, Division of Rheumatology, Hospital Universitario de Canarias. Drs. M.A. González-Gay and I. Ferraz-Amaro share senior authorship. Address correspondence to Dr. I. Ferraz-Amaro, Division of Rheumatology, Hospital Universitario de Canarias, 38320 Santa Cruz de Tenerife, Spain, e-mail: iferrazamaro@hotmail.com; Dr. M.Á. González-Gay, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, e-mail: miguelaggay@hotmail.com. Accepted for publication October 24, 2019.
Javier Llorca
From the Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, Instituto de Investigación Marqués de Valdecilla (IDIVAL), Santander; Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander; Division of Rheumatology, Hospital Doctor Negrín, Las Palmas de Gran Canaria, Gran Canaria; University of Cantabria, IDIVAL, Santander; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid; School of Medicine, University of Cantabria, Santander; Division of Rheumatology, Hospital Universitario de Canarias, Tenerife, Spain; Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. Supported by a grant to Dr. Ferraz-Amaro from the Spanish Ministry of Health, Subdirección General de Evaluación y Fomento de la Investigación, Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 and by Fondo Europeo de Desarrollo Regional (FEDER; Fondo de Investigaciones Sanitarias, FIS PI14/00394, PI17/00083). Prof. González-Gay’s research was supported by European Union FEDER funds and by the “Fondo de Investigación Sanitaria” (grants PI06/0024, PS09/00748, PI12/00060, PI15/00525 and PI18/00043) of the “Instituto de Salud Carlos III” (ISCIII; Health Ministry, Spain). It was also partially supported by RETICS (health research networks) Programs RD12/0009 (RIER), RD12/0009/0013 and RD16/0012 from the “Instituto de Salud Carlos III”. N. Palmou-Fontana, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; D. Martínez-López, MD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; A. Corrales, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; J. Rueda-Gotor, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; F. Genre, PhD, Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Hospital Universitario Marqués de Valdecilla, IDIVAL; S. Armesto, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; M.A. González-López, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; J.C. Quevedo-Abeledo, MD, Division of Rheumatology, Hospital Doctor Negrín, Las Palmas de Gran Canaria; V. Portilla-González, BSc, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; R. Blanco, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; J.L. Hernández, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; J. Llorca, MD, PhD, University of Cantabria, IDIVAL, and CIBERESP, and School of Medicine, University of Cantabria; M.A. González-Gay, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, and Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Hospital Universitario Marqués de Valdecilla, IDIVAL, and School of Medicine, University of Cantabria, and Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand; I. Ferraz-Amaro, MD, PhD, Division of Rheumatology, Hospital Universitario de Canarias. Drs. M.A. González-Gay and I. Ferraz-Amaro share senior authorship. Address correspondence to Dr. I. Ferraz-Amaro, Division of Rheumatology, Hospital Universitario de Canarias, 38320 Santa Cruz de Tenerife, Spain, e-mail: iferrazamaro@hotmail.com; Dr. M.Á. González-Gay, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, e-mail: miguelaggay@hotmail.com. Accepted for publication October 24, 2019.
Miguel Á. González-Gay
From the Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, Instituto de Investigación Marqués de Valdecilla (IDIVAL), Santander; Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander; Division of Rheumatology, Hospital Doctor Negrín, Las Palmas de Gran Canaria, Gran Canaria; University of Cantabria, IDIVAL, Santander; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid; School of Medicine, University of Cantabria, Santander; Division of Rheumatology, Hospital Universitario de Canarias, Tenerife, Spain; Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. Supported by a grant to Dr. Ferraz-Amaro from the Spanish Ministry of Health, Subdirección General de Evaluación y Fomento de la Investigación, Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 and by Fondo Europeo de Desarrollo Regional (FEDER; Fondo de Investigaciones Sanitarias, FIS PI14/00394, PI17/00083). Prof. González-Gay’s research was supported by European Union FEDER funds and by the “Fondo de Investigación Sanitaria” (grants PI06/0024, PS09/00748, PI12/00060, PI15/00525 and PI18/00043) of the “Instituto de Salud Carlos III” (ISCIII; Health Ministry, Spain). It was also partially supported by RETICS (health research networks) Programs RD12/0009 (RIER), RD12/0009/0013 and RD16/0012 from the “Instituto de Salud Carlos III”. N. Palmou-Fontana, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; D. Martínez-López, MD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; A. Corrales, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; J. Rueda-Gotor, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; F. Genre, PhD, Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Hospital Universitario Marqués de Valdecilla, IDIVAL; S. Armesto, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; M.A. González-López, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; J.C. Quevedo-Abeledo, MD, Division of Rheumatology, Hospital Doctor Negrín, Las Palmas de Gran Canaria; V. Portilla-González, BSc, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; R. Blanco, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; J.L. Hernández, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; J. Llorca, MD, PhD, University of Cantabria, IDIVAL, and CIBERESP, and School of Medicine, University of Cantabria; M.A. González-Gay, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, and Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Hospital Universitario Marqués de Valdecilla, IDIVAL, and School of Medicine, University of Cantabria, and Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand; I. Ferraz-Amaro, MD, PhD, Division of Rheumatology, Hospital Universitario de Canarias. Drs. M.A. González-Gay and I. Ferraz-Amaro share senior authorship. Address correspondence to Dr. I. Ferraz-Amaro, Division of Rheumatology, Hospital Universitario de Canarias, 38320 Santa Cruz de Tenerife, Spain, e-mail: iferrazamaro@hotmail.com; Dr. M.Á. González-Gay, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, e-mail: miguelaggay@hotmail.com. Accepted for publication October 24, 2019.
Iván Ferraz-Amaro
From the Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, Instituto de Investigación Marqués de Valdecilla (IDIVAL), Santander; Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander; Division of Rheumatology, Hospital Doctor Negrín, Las Palmas de Gran Canaria, Gran Canaria; University of Cantabria, IDIVAL, Santander; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid; School of Medicine, University of Cantabria, Santander; Division of Rheumatology, Hospital Universitario de Canarias, Tenerife, Spain; Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. Supported by a grant to Dr. Ferraz-Amaro from the Spanish Ministry of Health, Subdirección General de Evaluación y Fomento de la Investigación, Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 and by Fondo Europeo de Desarrollo Regional (FEDER; Fondo de Investigaciones Sanitarias, FIS PI14/00394, PI17/00083). Prof. González-Gay’s research was supported by European Union FEDER funds and by the “Fondo de Investigación Sanitaria” (grants PI06/0024, PS09/00748, PI12/00060, PI15/00525 and PI18/00043) of the “Instituto de Salud Carlos III” (ISCIII; Health Ministry, Spain). It was also partially supported by RETICS (health research networks) Programs RD12/0009 (RIER), RD12/0009/0013 and RD16/0012 from the “Instituto de Salud Carlos III”. N. Palmou-Fontana, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; D. Martínez-López, MD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; A. Corrales, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; J. Rueda-Gotor, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; F. Genre, PhD, Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Hospital Universitario Marqués de Valdecilla, IDIVAL; S. Armesto, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; M.A. González-López, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; J.C. Quevedo-Abeledo, MD, Division of Rheumatology, Hospital Doctor Negrín, Las Palmas de Gran Canaria; V. Portilla-González, BSc, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; R. Blanco, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; J.L. Hernández, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL; J. Llorca, MD, PhD, University of Cantabria, IDIVAL, and CIBERESP, and School of Medicine, University of Cantabria; M.A. González-Gay, MD, PhD, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, and Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Hospital Universitario Marqués de Valdecilla, IDIVAL, and School of Medicine, University of Cantabria, and Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand; I. Ferraz-Amaro, MD, PhD, Division of Rheumatology, Hospital Universitario de Canarias. Drs. M.A. González-Gay and I. Ferraz-Amaro share senior authorship. Address correspondence to Dr. I. Ferraz-Amaro, Division of Rheumatology, Hospital Universitario de Canarias, 38320 Santa Cruz de Tenerife, Spain, e-mail: iferrazamaro@hotmail.com; Dr. M.Á. González-Gay, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, e-mail: miguelaggay@hotmail.com. Accepted for publication October 24, 2019.
In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Disease Activity Influences Cardiovascular Risk Reclassification Based on Carotid Ultrasound in Patients with Psoriatic Arthritis
Natalia Palmou-Fontana, David Martínez-Lopez, Alfonso Corrales, Javier Rueda-Gotor, Fernanda Genre, Susana Armesto, Marcos A. González-López, Juan C. Quevedo-Abeledo, Virginia Portilla-González, Ricardo Blanco, José L. Hernandez, Javier Llorca, Miguel Á. González-Gay, Iván Ferraz-Amaro
The Journal of Rheumatology Nov 2019, jrheum.190729; DOI: 10.3899/jrheum.190729
Disease Activity Influences Cardiovascular Risk Reclassification Based on Carotid Ultrasound in Patients with Psoriatic Arthritis
Natalia Palmou-Fontana, David Martínez-Lopez, Alfonso Corrales, Javier Rueda-Gotor, Fernanda Genre, Susana Armesto, Marcos A. González-López, Juan C. Quevedo-Abeledo, Virginia Portilla-González, Ricardo Blanco, José L. Hernandez, Javier Llorca, Miguel Á. González-Gay, Iván Ferraz-Amaro
The Journal of Rheumatology Nov 2019, jrheum.190729; DOI: 10.3899/jrheum.190729