Research ArticleArticle
Analysis of 47 Non-MHC Ankylosing Spondylitis Susceptibility Loci Regarding Associated Variants across Whites and Han Chinese
Xuqi Zheng, Qiuxia Li, Xiaomin Li, Yanli Zhang, Xinyu Wu, Qiujing Wei, Shuangyan Cao, Mingcan Yang, Zhiming Lin, Zetao Liao, Jun Qi, Qing Lv, Ling Wang, Yi Li, Astrid Irwanto, Ching-Yu Cheng, Xiaoran Chai, Chiea Chuen Khor, Chew-Kiat Heng, Woon-Puay Koh, Jian-Min Yuan, Jinxin Bei, Furen Zhang, Xuejun Zhang, Yixin Zeng, Yan Shen, Jianjun Liu and Jieruo Gu
The Journal of Rheumatology September 2019, jrheum.190184; DOI: https://doi.org/10.3899/jrheum.190184
Xuqi Zheng
From the Department of Rheumatology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore; The Jackson Laboratory, Farmington, Connecticut, USA; the Singapore Eye Research Institute (SERI); the Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), the Health Systems and Services Research, Duke–National University of Singapore (NUS) Medical School; Departments of Ophthalmology and Pediatrics, Yong Loo Lin School of Medicine; the Khoo Teck Puat–National University Children’s Medical Institute; the Saw Swee Hock School of Public Health, National University of Singapore, Singapore; the division of Cancer Control and Population Sciences, University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou; Shandong Provincial Institute of Dermatology and Venereology and Hospital for Skin Diseases, Shandong First Medical University and Shandong Academy of Medical Sciences; National Clinical Key Project of Dermatology and Venereology, Jinan, Shandong; Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University, Guangzhou; Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University; Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University), Hefei; National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, and Peking Union Medical College, Beijing, China. This study was supported by the Science and Technology Planning Project of Guangdong Province, China (2016A020216013), Guangdong Natural Science Funds for Distinguished Young Scholars (Grant No. 2014A030306039), the Municipal Healthcare Joint-Innovation Major Project of Guangzhou and High-level Personnel of Special Support Program for Technology Innovative Talents and the Top Young of Guangdong Province (Grant No. 2015TQ01R516), the National Supercomputer Center in Guangzhou and the Agency of Science, Technology and Research (A*STAR) of Singapore, the HUJ-CREATE Programme of the National Research Foundation, Singapore (Project Number 370062002), the US National Institutes of Health (Grant Numbers R01CA144034 and UM1 CA182876), the Singapore National Medical Research Council (Grant Number 1270/2010), the 5010 Project of Sun Yat-sen University (Grant No. 2007023), Distinguished Young Scholar Candidates Programme for The Third Affiliated Hospital of Sun Yat-Sen University, and Pearl River Nova Program of Guangzhou (Grant No. 201610010005). X. Zheng, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Li, PhD, Third Affiliated Hospital of Sun Yat-sen University; X. Li, PhD, Third Affiliated Hospital of Sun Yat-sen University; Y. Zhang, PhD, Third Affiliated Hospital of Sun Yat-sen University; X. Wu, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Wei, BD, Third Affiliated Hospital of Sun Yat-sen University; S. Cao, BD, Third Affiliated Hospital of Sun Yat-sen University; M. Yang, PhD, Third Affiliated Hospital of Sun Yat-sen University; Z. Lin, PhD, Third Affiliated Hospital of Sun Yat-sen University; Z. Liao, PhD, Third Affiliated Hospital of Sun Yat-sen University; J. Qi, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Lv, PhD, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University; L. Wang, MD, Human Genetics, Genome Institute of Singapore, A*STAR; Y. Li, PhD, Human Genetics, Genome Institute of Singapore, A*STAR, and The Jackson Laboratory; A. Irwanto, PhD, Human Genetics, Genome Institute of Singapore, A*STAR; C. Cheng, PhD, SERI, Singapore National Eye Centre, Ophthalmology and Visual Sciences, Eye ACP, Duke-NUS Medical School, Department of Ophthalmology, Yong Loo Lin School of Medicine; X. Chai, PhD, SERI, Singapore National Eye Centre; C. Khor, PhD, Human Genetics, Genome Institute of Singapore, A*STAR; C. Heng, PhD, Department of Pediatrics, Yong Loo Lin School of Medicine, Khoo Teck Puat–National University Children’s Medical Institute, National University Health System; W. Koh, PhD, Saw Swee Hock School of Public Health, NUS, Health Systems and Services Research, Duke-NUS Medical School; J. Yuan, PhD, Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh; J. Bei, PhD, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center; F. Zhang, PhD, Shandong Provincial Institute of Dermatology and Venereology and Hospital for Skin Diseases, Shandong First Medical University and Shandong Academy of Medical Sciences; X. Zhang, PhD, Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University, Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University); Y. Zeng, PhD, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center; Y. Shen, PhD, National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College; J. Liu, PhD, Human Genetics, Genome Institute of Singapore, A*STAR, The Third Affiliated Hospital of Sun Yat-sen University; J. Gu, MD, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University. J. Liu and J. Gu jointly directed this work. X. Zheng and Q. Li contributed equally to this study. Address correspondence to Prof. J. Gu, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China; e-mail: gujieruo@163.com; or Prof. J. Liu, Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138672; e-mail: liuj3@gis.a-star.edu.sg. Accepted for publication August 23, 2019.
Qiuxia Li
From the Department of Rheumatology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore; The Jackson Laboratory, Farmington, Connecticut, USA; the Singapore Eye Research Institute (SERI); the Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), the Health Systems and Services Research, Duke–National University of Singapore (NUS) Medical School; Departments of Ophthalmology and Pediatrics, Yong Loo Lin School of Medicine; the Khoo Teck Puat–National University Children’s Medical Institute; the Saw Swee Hock School of Public Health, National University of Singapore, Singapore; the division of Cancer Control and Population Sciences, University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou; Shandong Provincial Institute of Dermatology and Venereology and Hospital for Skin Diseases, Shandong First Medical University and Shandong Academy of Medical Sciences; National Clinical Key Project of Dermatology and Venereology, Jinan, Shandong; Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University, Guangzhou; Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University; Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University), Hefei; National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, and Peking Union Medical College, Beijing, China. This study was supported by the Science and Technology Planning Project of Guangdong Province, China (2016A020216013), Guangdong Natural Science Funds for Distinguished Young Scholars (Grant No. 2014A030306039), the Municipal Healthcare Joint-Innovation Major Project of Guangzhou and High-level Personnel of Special Support Program for Technology Innovative Talents and the Top Young of Guangdong Province (Grant No. 2015TQ01R516), the National Supercomputer Center in Guangzhou and the Agency of Science, Technology and Research (A*STAR) of Singapore, the HUJ-CREATE Programme of the National Research Foundation, Singapore (Project Number 370062002), the US National Institutes of Health (Grant Numbers R01CA144034 and UM1 CA182876), the Singapore National Medical Research Council (Grant Number 1270/2010), the 5010 Project of Sun Yat-sen University (Grant No. 2007023), Distinguished Young Scholar Candidates Programme for The Third Affiliated Hospital of Sun Yat-Sen University, and Pearl River Nova Program of Guangzhou (Grant No. 201610010005). X. Zheng, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Li, PhD, Third Affiliated Hospital of Sun Yat-sen University; X. Li, PhD, Third Affiliated Hospital of Sun Yat-sen University; Y. Zhang, PhD, Third Affiliated Hospital of Sun Yat-sen University; X. Wu, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Wei, BD, Third Affiliated Hospital of Sun Yat-sen University; S. Cao, BD, Third Affiliated Hospital of Sun Yat-sen University; M. Yang, PhD, Third Affiliated Hospital of Sun Yat-sen University; Z. Lin, PhD, Third Affiliated Hospital of Sun Yat-sen University; Z. Liao, PhD, Third Affiliated Hospital of Sun Yat-sen University; J. Qi, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Lv, PhD, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University; L. Wang, MD, Human Genetics, Genome Institute of Singapore, A*STAR; Y. Li, PhD, Human Genetics, Genome Institute of Singapore, A*STAR, and The Jackson Laboratory; A. Irwanto, PhD, Human Genetics, Genome Institute of Singapore, A*STAR; C. Cheng, PhD, SERI, Singapore National Eye Centre, Ophthalmology and Visual Sciences, Eye ACP, Duke-NUS Medical School, Department of Ophthalmology, Yong Loo Lin School of Medicine; X. Chai, PhD, SERI, Singapore National Eye Centre; C. Khor, PhD, Human Genetics, Genome Institute of Singapore, A*STAR; C. Heng, PhD, Department of Pediatrics, Yong Loo Lin School of Medicine, Khoo Teck Puat–National University Children’s Medical Institute, National University Health System; W. Koh, PhD, Saw Swee Hock School of Public Health, NUS, Health Systems and Services Research, Duke-NUS Medical School; J. Yuan, PhD, Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh; J. Bei, PhD, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center; F. Zhang, PhD, Shandong Provincial Institute of Dermatology and Venereology and Hospital for Skin Diseases, Shandong First Medical University and Shandong Academy of Medical Sciences; X. Zhang, PhD, Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University, Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University); Y. Zeng, PhD, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center; Y. Shen, PhD, National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College; J. Liu, PhD, Human Genetics, Genome Institute of Singapore, A*STAR, The Third Affiliated Hospital of Sun Yat-sen University; J. Gu, MD, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University. J. Liu and J. Gu jointly directed this work. X. Zheng and Q. Li contributed equally to this study. Address correspondence to Prof. J. Gu, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China; e-mail: gujieruo@163.com; or Prof. J. Liu, Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138672; e-mail: liuj3@gis.a-star.edu.sg. Accepted for publication August 23, 2019.
Xiaomin Li
From the Department of Rheumatology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore; The Jackson Laboratory, Farmington, Connecticut, USA; the Singapore Eye Research Institute (SERI); the Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), the Health Systems and Services Research, Duke–National University of Singapore (NUS) Medical School; Departments of Ophthalmology and Pediatrics, Yong Loo Lin School of Medicine; the Khoo Teck Puat–National University Children’s Medical Institute; the Saw Swee Hock School of Public Health, National University of Singapore, Singapore; the division of Cancer Control and Population Sciences, University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou; Shandong Provincial Institute of Dermatology and Venereology and Hospital for Skin Diseases, Shandong First Medical University and Shandong Academy of Medical Sciences; National Clinical Key Project of Dermatology and Venereology, Jinan, Shandong; Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University, Guangzhou; Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University; Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University), Hefei; National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, and Peking Union Medical College, Beijing, China. This study was supported by the Science and Technology Planning Project of Guangdong Province, China (2016A020216013), Guangdong Natural Science Funds for Distinguished Young Scholars (Grant No. 2014A030306039), the Municipal Healthcare Joint-Innovation Major Project of Guangzhou and High-level Personnel of Special Support Program for Technology Innovative Talents and the Top Young of Guangdong Province (Grant No. 2015TQ01R516), the National Supercomputer Center in Guangzhou and the Agency of Science, Technology and Research (A*STAR) of Singapore, the HUJ-CREATE Programme of the National Research Foundation, Singapore (Project Number 370062002), the US National Institutes of Health (Grant Numbers R01CA144034 and UM1 CA182876), the Singapore National Medical Research Council (Grant Number 1270/2010), the 5010 Project of Sun Yat-sen University (Grant No. 2007023), Distinguished Young Scholar Candidates Programme for The Third Affiliated Hospital of Sun Yat-Sen University, and Pearl River Nova Program of Guangzhou (Grant No. 201610010005). X. Zheng, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Li, PhD, Third Affiliated Hospital of Sun Yat-sen University; X. Li, PhD, Third Affiliated Hospital of Sun Yat-sen University; Y. Zhang, PhD, Third Affiliated Hospital of Sun Yat-sen University; X. Wu, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Wei, BD, Third Affiliated Hospital of Sun Yat-sen University; S. Cao, BD, Third Affiliated Hospital of Sun Yat-sen University; M. Yang, PhD, Third Affiliated Hospital of Sun Yat-sen University; Z. Lin, PhD, Third Affiliated Hospital of Sun Yat-sen University; Z. Liao, PhD, Third Affiliated Hospital of Sun Yat-sen University; J. Qi, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Lv, PhD, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University; L. Wang, MD, Human Genetics, Genome Institute of Singapore, A*STAR; Y. Li, PhD, Human Genetics, Genome Institute of Singapore, A*STAR, and The Jackson Laboratory; A. Irwanto, PhD, Human Genetics, Genome Institute of Singapore, A*STAR; C. Cheng, PhD, SERI, Singapore National Eye Centre, Ophthalmology and Visual Sciences, Eye ACP, Duke-NUS Medical School, Department of Ophthalmology, Yong Loo Lin School of Medicine; X. Chai, PhD, SERI, Singapore National Eye Centre; C. Khor, PhD, Human Genetics, Genome Institute of Singapore, A*STAR; C. Heng, PhD, Department of Pediatrics, Yong Loo Lin School of Medicine, Khoo Teck Puat–National University Children’s Medical Institute, National University Health System; W. Koh, PhD, Saw Swee Hock School of Public Health, NUS, Health Systems and Services Research, Duke-NUS Medical School; J. Yuan, PhD, Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh; J. Bei, PhD, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center; F. Zhang, PhD, Shandong Provincial Institute of Dermatology and Venereology and Hospital for Skin Diseases, Shandong First Medical University and Shandong Academy of Medical Sciences; X. Zhang, PhD, Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University, Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University); Y. Zeng, PhD, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center; Y. Shen, PhD, National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College; J. Liu, PhD, Human Genetics, Genome Institute of Singapore, A*STAR, The Third Affiliated Hospital of Sun Yat-sen University; J. Gu, MD, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University. J. Liu and J. Gu jointly directed this work. X. Zheng and Q. Li contributed equally to this study. Address correspondence to Prof. J. Gu, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China; e-mail: gujieruo@163.com; or Prof. J. Liu, Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138672; e-mail: liuj3@gis.a-star.edu.sg. Accepted for publication August 23, 2019.
Yanli Zhang
From the Department of Rheumatology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore; The Jackson Laboratory, Farmington, Connecticut, USA; the Singapore Eye Research Institute (SERI); the Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), the Health Systems and Services Research, Duke–National University of Singapore (NUS) Medical School; Departments of Ophthalmology and Pediatrics, Yong Loo Lin School of Medicine; the Khoo Teck Puat–National University Children’s Medical Institute; the Saw Swee Hock School of Public Health, National University of Singapore, Singapore; the division of Cancer Control and Population Sciences, University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou; Shandong Provincial Institute of Dermatology and Venereology and Hospital for Skin Diseases, Shandong First Medical University and Shandong Academy of Medical Sciences; National Clinical Key Project of Dermatology and Venereology, Jinan, Shandong; Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University, Guangzhou; Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University; Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University), Hefei; National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, and Peking Union Medical College, Beijing, China. This study was supported by the Science and Technology Planning Project of Guangdong Province, China (2016A020216013), Guangdong Natural Science Funds for Distinguished Young Scholars (Grant No. 2014A030306039), the Municipal Healthcare Joint-Innovation Major Project of Guangzhou and High-level Personnel of Special Support Program for Technology Innovative Talents and the Top Young of Guangdong Province (Grant No. 2015TQ01R516), the National Supercomputer Center in Guangzhou and the Agency of Science, Technology and Research (A*STAR) of Singapore, the HUJ-CREATE Programme of the National Research Foundation, Singapore (Project Number 370062002), the US National Institutes of Health (Grant Numbers R01CA144034 and UM1 CA182876), the Singapore National Medical Research Council (Grant Number 1270/2010), the 5010 Project of Sun Yat-sen University (Grant No. 2007023), Distinguished Young Scholar Candidates Programme for The Third Affiliated Hospital of Sun Yat-Sen University, and Pearl River Nova Program of Guangzhou (Grant No. 201610010005). X. Zheng, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Li, PhD, Third Affiliated Hospital of Sun Yat-sen University; X. Li, PhD, Third Affiliated Hospital of Sun Yat-sen University; Y. Zhang, PhD, Third Affiliated Hospital of Sun Yat-sen University; X. Wu, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Wei, BD, Third Affiliated Hospital of Sun Yat-sen University; S. Cao, BD, Third Affiliated Hospital of Sun Yat-sen University; M. Yang, PhD, Third Affiliated Hospital of Sun Yat-sen University; Z. Lin, PhD, Third Affiliated Hospital of Sun Yat-sen University; Z. Liao, PhD, Third Affiliated Hospital of Sun Yat-sen University; J. Qi, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Lv, PhD, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University; L. Wang, MD, Human Genetics, Genome Institute of Singapore, A*STAR; Y. Li, PhD, Human Genetics, Genome Institute of Singapore, A*STAR, and The Jackson Laboratory; A. Irwanto, PhD, Human Genetics, Genome Institute of Singapore, A*STAR; C. Cheng, PhD, SERI, Singapore National Eye Centre, Ophthalmology and Visual Sciences, Eye ACP, Duke-NUS Medical School, Department of Ophthalmology, Yong Loo Lin School of Medicine; X. Chai, PhD, SERI, Singapore National Eye Centre; C. Khor, PhD, Human Genetics, Genome Institute of Singapore, A*STAR; C. Heng, PhD, Department of Pediatrics, Yong Loo Lin School of Medicine, Khoo Teck Puat–National University Children’s Medical Institute, National University Health System; W. Koh, PhD, Saw Swee Hock School of Public Health, NUS, Health Systems and Services Research, Duke-NUS Medical School; J. Yuan, PhD, Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh; J. Bei, PhD, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center; F. Zhang, PhD, Shandong Provincial Institute of Dermatology and Venereology and Hospital for Skin Diseases, Shandong First Medical University and Shandong Academy of Medical Sciences; X. Zhang, PhD, Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University, Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University); Y. Zeng, PhD, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center; Y. Shen, PhD, National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College; J. Liu, PhD, Human Genetics, Genome Institute of Singapore, A*STAR, The Third Affiliated Hospital of Sun Yat-sen University; J. Gu, MD, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University. J. Liu and J. Gu jointly directed this work. X. Zheng and Q. Li contributed equally to this study. Address correspondence to Prof. J. Gu, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China; e-mail: gujieruo@163.com; or Prof. J. Liu, Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138672; e-mail: liuj3@gis.a-star.edu.sg. Accepted for publication August 23, 2019.
Xinyu Wu
From the Department of Rheumatology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore; The Jackson Laboratory, Farmington, Connecticut, USA; the Singapore Eye Research Institute (SERI); the Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), the Health Systems and Services Research, Duke–National University of Singapore (NUS) Medical School; Departments of Ophthalmology and Pediatrics, Yong Loo Lin School of Medicine; the Khoo Teck Puat–National University Children’s Medical Institute; the Saw Swee Hock School of Public Health, National University of Singapore, Singapore; the division of Cancer Control and Population Sciences, University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou; Shandong Provincial Institute of Dermatology and Venereology and Hospital for Skin Diseases, Shandong First Medical University and Shandong Academy of Medical Sciences; National Clinical Key Project of Dermatology and Venereology, Jinan, Shandong; Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University, Guangzhou; Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University; Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University), Hefei; National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, and Peking Union Medical College, Beijing, China. This study was supported by the Science and Technology Planning Project of Guangdong Province, China (2016A020216013), Guangdong Natural Science Funds for Distinguished Young Scholars (Grant No. 2014A030306039), the Municipal Healthcare Joint-Innovation Major Project of Guangzhou and High-level Personnel of Special Support Program for Technology Innovative Talents and the Top Young of Guangdong Province (Grant No. 2015TQ01R516), the National Supercomputer Center in Guangzhou and the Agency of Science, Technology and Research (A*STAR) of Singapore, the HUJ-CREATE Programme of the National Research Foundation, Singapore (Project Number 370062002), the US National Institutes of Health (Grant Numbers R01CA144034 and UM1 CA182876), the Singapore National Medical Research Council (Grant Number 1270/2010), the 5010 Project of Sun Yat-sen University (Grant No. 2007023), Distinguished Young Scholar Candidates Programme for The Third Affiliated Hospital of Sun Yat-Sen University, and Pearl River Nova Program of Guangzhou (Grant No. 201610010005). X. Zheng, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Li, PhD, Third Affiliated Hospital of Sun Yat-sen University; X. Li, PhD, Third Affiliated Hospital of Sun Yat-sen University; Y. Zhang, PhD, Third Affiliated Hospital of Sun Yat-sen University; X. Wu, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Wei, BD, Third Affiliated Hospital of Sun Yat-sen University; S. Cao, BD, Third Affiliated Hospital of Sun Yat-sen University; M. Yang, PhD, Third Affiliated Hospital of Sun Yat-sen University; Z. Lin, PhD, Third Affiliated Hospital of Sun Yat-sen University; Z. Liao, PhD, Third Affiliated Hospital of Sun Yat-sen University; J. Qi, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Lv, PhD, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University; L. Wang, MD, Human Genetics, Genome Institute of Singapore, A*STAR; Y. Li, PhD, Human Genetics, Genome Institute of Singapore, A*STAR, and The Jackson Laboratory; A. Irwanto, PhD, Human Genetics, Genome Institute of Singapore, A*STAR; C. Cheng, PhD, SERI, Singapore National Eye Centre, Ophthalmology and Visual Sciences, Eye ACP, Duke-NUS Medical School, Department of Ophthalmology, Yong Loo Lin School of Medicine; X. Chai, PhD, SERI, Singapore National Eye Centre; C. Khor, PhD, Human Genetics, Genome Institute of Singapore, A*STAR; C. Heng, PhD, Department of Pediatrics, Yong Loo Lin School of Medicine, Khoo Teck Puat–National University Children’s Medical Institute, National University Health System; W. Koh, PhD, Saw Swee Hock School of Public Health, NUS, Health Systems and Services Research, Duke-NUS Medical School; J. Yuan, PhD, Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh; J. Bei, PhD, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center; F. Zhang, PhD, Shandong Provincial Institute of Dermatology and Venereology and Hospital for Skin Diseases, Shandong First Medical University and Shandong Academy of Medical Sciences; X. Zhang, PhD, Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University, Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University); Y. Zeng, PhD, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center; Y. Shen, PhD, National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College; J. Liu, PhD, Human Genetics, Genome Institute of Singapore, A*STAR, The Third Affiliated Hospital of Sun Yat-sen University; J. Gu, MD, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University. J. Liu and J. Gu jointly directed this work. X. Zheng and Q. Li contributed equally to this study. Address correspondence to Prof. J. Gu, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China; e-mail: gujieruo@163.com; or Prof. J. Liu, Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138672; e-mail: liuj3@gis.a-star.edu.sg. Accepted for publication August 23, 2019.
Qiujing Wei
From the Department of Rheumatology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore; The Jackson Laboratory, Farmington, Connecticut, USA; the Singapore Eye Research Institute (SERI); the Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), the Health Systems and Services Research, Duke–National University of Singapore (NUS) Medical School; Departments of Ophthalmology and Pediatrics, Yong Loo Lin School of Medicine; the Khoo Teck Puat–National University Children’s Medical Institute; the Saw Swee Hock School of Public Health, National University of Singapore, Singapore; the division of Cancer Control and Population Sciences, University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou; Shandong Provincial Institute of Dermatology and Venereology and Hospital for Skin Diseases, Shandong First Medical University and Shandong Academy of Medical Sciences; National Clinical Key Project of Dermatology and Venereology, Jinan, Shandong; Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University, Guangzhou; Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University; Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University), Hefei; National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, and Peking Union Medical College, Beijing, China. This study was supported by the Science and Technology Planning Project of Guangdong Province, China (2016A020216013), Guangdong Natural Science Funds for Distinguished Young Scholars (Grant No. 2014A030306039), the Municipal Healthcare Joint-Innovation Major Project of Guangzhou and High-level Personnel of Special Support Program for Technology Innovative Talents and the Top Young of Guangdong Province (Grant No. 2015TQ01R516), the National Supercomputer Center in Guangzhou and the Agency of Science, Technology and Research (A*STAR) of Singapore, the HUJ-CREATE Programme of the National Research Foundation, Singapore (Project Number 370062002), the US National Institutes of Health (Grant Numbers R01CA144034 and UM1 CA182876), the Singapore National Medical Research Council (Grant Number 1270/2010), the 5010 Project of Sun Yat-sen University (Grant No. 2007023), Distinguished Young Scholar Candidates Programme for The Third Affiliated Hospital of Sun Yat-Sen University, and Pearl River Nova Program of Guangzhou (Grant No. 201610010005). X. Zheng, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Li, PhD, Third Affiliated Hospital of Sun Yat-sen University; X. Li, PhD, Third Affiliated Hospital of Sun Yat-sen University; Y. Zhang, PhD, Third Affiliated Hospital of Sun Yat-sen University; X. Wu, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Wei, BD, Third Affiliated Hospital of Sun Yat-sen University; S. Cao, BD, Third Affiliated Hospital of Sun Yat-sen University; M. Yang, PhD, Third Affiliated Hospital of Sun Yat-sen University; Z. Lin, PhD, Third Affiliated Hospital of Sun Yat-sen University; Z. Liao, PhD, Third Affiliated Hospital of Sun Yat-sen University; J. Qi, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Lv, PhD, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University; L. Wang, MD, Human Genetics, Genome Institute of Singapore, A*STAR; Y. Li, PhD, Human Genetics, Genome Institute of Singapore, A*STAR, and The Jackson Laboratory; A. Irwanto, PhD, Human Genetics, Genome Institute of Singapore, A*STAR; C. Cheng, PhD, SERI, Singapore National Eye Centre, Ophthalmology and Visual Sciences, Eye ACP, Duke-NUS Medical School, Department of Ophthalmology, Yong Loo Lin School of Medicine; X. Chai, PhD, SERI, Singapore National Eye Centre; C. Khor, PhD, Human Genetics, Genome Institute of Singapore, A*STAR; C. Heng, PhD, Department of Pediatrics, Yong Loo Lin School of Medicine, Khoo Teck Puat–National University Children’s Medical Institute, National University Health System; W. Koh, PhD, Saw Swee Hock School of Public Health, NUS, Health Systems and Services Research, Duke-NUS Medical School; J. Yuan, PhD, Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh; J. Bei, PhD, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center; F. Zhang, PhD, Shandong Provincial Institute of Dermatology and Venereology and Hospital for Skin Diseases, Shandong First Medical University and Shandong Academy of Medical Sciences; X. Zhang, PhD, Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University, Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University); Y. Zeng, PhD, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center; Y. Shen, PhD, National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College; J. Liu, PhD, Human Genetics, Genome Institute of Singapore, A*STAR, The Third Affiliated Hospital of Sun Yat-sen University; J. Gu, MD, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University. J. Liu and J. Gu jointly directed this work. X. Zheng and Q. Li contributed equally to this study. Address correspondence to Prof. J. Gu, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China; e-mail: gujieruo@163.com; or Prof. J. Liu, Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138672; e-mail: liuj3@gis.a-star.edu.sg. Accepted for publication August 23, 2019.
Shuangyan Cao
From the Department of Rheumatology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore; The Jackson Laboratory, Farmington, Connecticut, USA; the Singapore Eye Research Institute (SERI); the Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), the Health Systems and Services Research, Duke–National University of Singapore (NUS) Medical School; Departments of Ophthalmology and Pediatrics, Yong Loo Lin School of Medicine; the Khoo Teck Puat–National University Children’s Medical Institute; the Saw Swee Hock School of Public Health, National University of Singapore, Singapore; the division of Cancer Control and Population Sciences, University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou; Shandong Provincial Institute of Dermatology and Venereology and Hospital for Skin Diseases, Shandong First Medical University and Shandong Academy of Medical Sciences; National Clinical Key Project of Dermatology and Venereology, Jinan, Shandong; Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University, Guangzhou; Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University; Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University), Hefei; National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, and Peking Union Medical College, Beijing, China. This study was supported by the Science and Technology Planning Project of Guangdong Province, China (2016A020216013), Guangdong Natural Science Funds for Distinguished Young Scholars (Grant No. 2014A030306039), the Municipal Healthcare Joint-Innovation Major Project of Guangzhou and High-level Personnel of Special Support Program for Technology Innovative Talents and the Top Young of Guangdong Province (Grant No. 2015TQ01R516), the National Supercomputer Center in Guangzhou and the Agency of Science, Technology and Research (A*STAR) of Singapore, the HUJ-CREATE Programme of the National Research Foundation, Singapore (Project Number 370062002), the US National Institutes of Health (Grant Numbers R01CA144034 and UM1 CA182876), the Singapore National Medical Research Council (Grant Number 1270/2010), the 5010 Project of Sun Yat-sen University (Grant No. 2007023), Distinguished Young Scholar Candidates Programme for The Third Affiliated Hospital of Sun Yat-Sen University, and Pearl River Nova Program of Guangzhou (Grant No. 201610010005). X. Zheng, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Li, PhD, Third Affiliated Hospital of Sun Yat-sen University; X. Li, PhD, Third Affiliated Hospital of Sun Yat-sen University; Y. Zhang, PhD, Third Affiliated Hospital of Sun Yat-sen University; X. Wu, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Wei, BD, Third Affiliated Hospital of Sun Yat-sen University; S. Cao, BD, Third Affiliated Hospital of Sun Yat-sen University; M. Yang, PhD, Third Affiliated Hospital of Sun Yat-sen University; Z. Lin, PhD, Third Affiliated Hospital of Sun Yat-sen University; Z. Liao, PhD, Third Affiliated Hospital of Sun Yat-sen University; J. Qi, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Lv, PhD, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University; L. Wang, MD, Human Genetics, Genome Institute of Singapore, A*STAR; Y. Li, PhD, Human Genetics, Genome Institute of Singapore, A*STAR, and The Jackson Laboratory; A. Irwanto, PhD, Human Genetics, Genome Institute of Singapore, A*STAR; C. Cheng, PhD, SERI, Singapore National Eye Centre, Ophthalmology and Visual Sciences, Eye ACP, Duke-NUS Medical School, Department of Ophthalmology, Yong Loo Lin School of Medicine; X. Chai, PhD, SERI, Singapore National Eye Centre; C. Khor, PhD, Human Genetics, Genome Institute of Singapore, A*STAR; C. Heng, PhD, Department of Pediatrics, Yong Loo Lin School of Medicine, Khoo Teck Puat–National University Children’s Medical Institute, National University Health System; W. Koh, PhD, Saw Swee Hock School of Public Health, NUS, Health Systems and Services Research, Duke-NUS Medical School; J. Yuan, PhD, Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh; J. Bei, PhD, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center; F. Zhang, PhD, Shandong Provincial Institute of Dermatology and Venereology and Hospital for Skin Diseases, Shandong First Medical University and Shandong Academy of Medical Sciences; X. Zhang, PhD, Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University, Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University); Y. Zeng, PhD, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center; Y. Shen, PhD, National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College; J. Liu, PhD, Human Genetics, Genome Institute of Singapore, A*STAR, The Third Affiliated Hospital of Sun Yat-sen University; J. Gu, MD, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University. J. Liu and J. Gu jointly directed this work. X. Zheng and Q. Li contributed equally to this study. Address correspondence to Prof. J. Gu, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China; e-mail: gujieruo@163.com; or Prof. J. Liu, Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138672; e-mail: liuj3@gis.a-star.edu.sg. Accepted for publication August 23, 2019.
Mingcan Yang
From the Department of Rheumatology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore; The Jackson Laboratory, Farmington, Connecticut, USA; the Singapore Eye Research Institute (SERI); the Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), the Health Systems and Services Research, Duke–National University of Singapore (NUS) Medical School; Departments of Ophthalmology and Pediatrics, Yong Loo Lin School of Medicine; the Khoo Teck Puat–National University Children’s Medical Institute; the Saw Swee Hock School of Public Health, National University of Singapore, Singapore; the division of Cancer Control and Population Sciences, University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou; Shandong Provincial Institute of Dermatology and Venereology and Hospital for Skin Diseases, Shandong First Medical University and Shandong Academy of Medical Sciences; National Clinical Key Project of Dermatology and Venereology, Jinan, Shandong; Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University, Guangzhou; Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University; Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University), Hefei; National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, and Peking Union Medical College, Beijing, China. This study was supported by the Science and Technology Planning Project of Guangdong Province, China (2016A020216013), Guangdong Natural Science Funds for Distinguished Young Scholars (Grant No. 2014A030306039), the Municipal Healthcare Joint-Innovation Major Project of Guangzhou and High-level Personnel of Special Support Program for Technology Innovative Talents and the Top Young of Guangdong Province (Grant No. 2015TQ01R516), the National Supercomputer Center in Guangzhou and the Agency of Science, Technology and Research (A*STAR) of Singapore, the HUJ-CREATE Programme of the National Research Foundation, Singapore (Project Number 370062002), the US National Institutes of Health (Grant Numbers R01CA144034 and UM1 CA182876), the Singapore National Medical Research Council (Grant Number 1270/2010), the 5010 Project of Sun Yat-sen University (Grant No. 2007023), Distinguished Young Scholar Candidates Programme for The Third Affiliated Hospital of Sun Yat-Sen University, and Pearl River Nova Program of Guangzhou (Grant No. 201610010005). X. Zheng, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Li, PhD, Third Affiliated Hospital of Sun Yat-sen University; X. Li, PhD, Third Affiliated Hospital of Sun Yat-sen University; Y. Zhang, PhD, Third Affiliated Hospital of Sun Yat-sen University; X. Wu, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Wei, BD, Third Affiliated Hospital of Sun Yat-sen University; S. Cao, BD, Third Affiliated Hospital of Sun Yat-sen University; M. Yang, PhD, Third Affiliated Hospital of Sun Yat-sen University; Z. Lin, PhD, Third Affiliated Hospital of Sun Yat-sen University; Z. Liao, PhD, Third Affiliated Hospital of Sun Yat-sen University; J. Qi, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Lv, PhD, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University; L. Wang, MD, Human Genetics, Genome Institute of Singapore, A*STAR; Y. Li, PhD, Human Genetics, Genome Institute of Singapore, A*STAR, and The Jackson Laboratory; A. Irwanto, PhD, Human Genetics, Genome Institute of Singapore, A*STAR; C. Cheng, PhD, SERI, Singapore National Eye Centre, Ophthalmology and Visual Sciences, Eye ACP, Duke-NUS Medical School, Department of Ophthalmology, Yong Loo Lin School of Medicine; X. Chai, PhD, SERI, Singapore National Eye Centre; C. Khor, PhD, Human Genetics, Genome Institute of Singapore, A*STAR; C. Heng, PhD, Department of Pediatrics, Yong Loo Lin School of Medicine, Khoo Teck Puat–National University Children’s Medical Institute, National University Health System; W. Koh, PhD, Saw Swee Hock School of Public Health, NUS, Health Systems and Services Research, Duke-NUS Medical School; J. Yuan, PhD, Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh; J. Bei, PhD, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center; F. Zhang, PhD, Shandong Provincial Institute of Dermatology and Venereology and Hospital for Skin Diseases, Shandong First Medical University and Shandong Academy of Medical Sciences; X. Zhang, PhD, Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University, Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University); Y. Zeng, PhD, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center; Y. Shen, PhD, National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College; J. Liu, PhD, Human Genetics, Genome Institute of Singapore, A*STAR, The Third Affiliated Hospital of Sun Yat-sen University; J. Gu, MD, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University. J. Liu and J. Gu jointly directed this work. X. Zheng and Q. Li contributed equally to this study. Address correspondence to Prof. J. Gu, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China; e-mail: gujieruo@163.com; or Prof. J. Liu, Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138672; e-mail: liuj3@gis.a-star.edu.sg. Accepted for publication August 23, 2019.
Zhiming Lin
From the Department of Rheumatology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore; The Jackson Laboratory, Farmington, Connecticut, USA; the Singapore Eye Research Institute (SERI); the Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), the Health Systems and Services Research, Duke–National University of Singapore (NUS) Medical School; Departments of Ophthalmology and Pediatrics, Yong Loo Lin School of Medicine; the Khoo Teck Puat–National University Children’s Medical Institute; the Saw Swee Hock School of Public Health, National University of Singapore, Singapore; the division of Cancer Control and Population Sciences, University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou; Shandong Provincial Institute of Dermatology and Venereology and Hospital for Skin Diseases, Shandong First Medical University and Shandong Academy of Medical Sciences; National Clinical Key Project of Dermatology and Venereology, Jinan, Shandong; Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University, Guangzhou; Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University; Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University), Hefei; National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, and Peking Union Medical College, Beijing, China. This study was supported by the Science and Technology Planning Project of Guangdong Province, China (2016A020216013), Guangdong Natural Science Funds for Distinguished Young Scholars (Grant No. 2014A030306039), the Municipal Healthcare Joint-Innovation Major Project of Guangzhou and High-level Personnel of Special Support Program for Technology Innovative Talents and the Top Young of Guangdong Province (Grant No. 2015TQ01R516), the National Supercomputer Center in Guangzhou and the Agency of Science, Technology and Research (A*STAR) of Singapore, the HUJ-CREATE Programme of the National Research Foundation, Singapore (Project Number 370062002), the US National Institutes of Health (Grant Numbers R01CA144034 and UM1 CA182876), the Singapore National Medical Research Council (Grant Number 1270/2010), the 5010 Project of Sun Yat-sen University (Grant No. 2007023), Distinguished Young Scholar Candidates Programme for The Third Affiliated Hospital of Sun Yat-Sen University, and Pearl River Nova Program of Guangzhou (Grant No. 201610010005). X. Zheng, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Li, PhD, Third Affiliated Hospital of Sun Yat-sen University; X. Li, PhD, Third Affiliated Hospital of Sun Yat-sen University; Y. Zhang, PhD, Third Affiliated Hospital of Sun Yat-sen University; X. Wu, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Wei, BD, Third Affiliated Hospital of Sun Yat-sen University; S. Cao, BD, Third Affiliated Hospital of Sun Yat-sen University; M. Yang, PhD, Third Affiliated Hospital of Sun Yat-sen University; Z. Lin, PhD, Third Affiliated Hospital of Sun Yat-sen University; Z. Liao, PhD, Third Affiliated Hospital of Sun Yat-sen University; J. Qi, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Lv, PhD, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University; L. Wang, MD, Human Genetics, Genome Institute of Singapore, A*STAR; Y. Li, PhD, Human Genetics, Genome Institute of Singapore, A*STAR, and The Jackson Laboratory; A. Irwanto, PhD, Human Genetics, Genome Institute of Singapore, A*STAR; C. Cheng, PhD, SERI, Singapore National Eye Centre, Ophthalmology and Visual Sciences, Eye ACP, Duke-NUS Medical School, Department of Ophthalmology, Yong Loo Lin School of Medicine; X. Chai, PhD, SERI, Singapore National Eye Centre; C. Khor, PhD, Human Genetics, Genome Institute of Singapore, A*STAR; C. Heng, PhD, Department of Pediatrics, Yong Loo Lin School of Medicine, Khoo Teck Puat–National University Children’s Medical Institute, National University Health System; W. Koh, PhD, Saw Swee Hock School of Public Health, NUS, Health Systems and Services Research, Duke-NUS Medical School; J. Yuan, PhD, Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh; J. Bei, PhD, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center; F. Zhang, PhD, Shandong Provincial Institute of Dermatology and Venereology and Hospital for Skin Diseases, Shandong First Medical University and Shandong Academy of Medical Sciences; X. Zhang, PhD, Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University, Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University); Y. Zeng, PhD, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center; Y. Shen, PhD, National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College; J. Liu, PhD, Human Genetics, Genome Institute of Singapore, A*STAR, The Third Affiliated Hospital of Sun Yat-sen University; J. Gu, MD, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University. J. Liu and J. Gu jointly directed this work. X. Zheng and Q. Li contributed equally to this study. Address correspondence to Prof. J. Gu, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China; e-mail: gujieruo@163.com; or Prof. J. Liu, Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138672; e-mail: liuj3@gis.a-star.edu.sg. Accepted for publication August 23, 2019.
Zetao Liao
From the Department of Rheumatology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore; The Jackson Laboratory, Farmington, Connecticut, USA; the Singapore Eye Research Institute (SERI); the Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), the Health Systems and Services Research, Duke–National University of Singapore (NUS) Medical School; Departments of Ophthalmology and Pediatrics, Yong Loo Lin School of Medicine; the Khoo Teck Puat–National University Children’s Medical Institute; the Saw Swee Hock School of Public Health, National University of Singapore, Singapore; the division of Cancer Control and Population Sciences, University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou; Shandong Provincial Institute of Dermatology and Venereology and Hospital for Skin Diseases, Shandong First Medical University and Shandong Academy of Medical Sciences; National Clinical Key Project of Dermatology and Venereology, Jinan, Shandong; Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University, Guangzhou; Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University; Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University), Hefei; National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, and Peking Union Medical College, Beijing, China. This study was supported by the Science and Technology Planning Project of Guangdong Province, China (2016A020216013), Guangdong Natural Science Funds for Distinguished Young Scholars (Grant No. 2014A030306039), the Municipal Healthcare Joint-Innovation Major Project of Guangzhou and High-level Personnel of Special Support Program for Technology Innovative Talents and the Top Young of Guangdong Province (Grant No. 2015TQ01R516), the National Supercomputer Center in Guangzhou and the Agency of Science, Technology and Research (A*STAR) of Singapore, the HUJ-CREATE Programme of the National Research Foundation, Singapore (Project Number 370062002), the US National Institutes of Health (Grant Numbers R01CA144034 and UM1 CA182876), the Singapore National Medical Research Council (Grant Number 1270/2010), the 5010 Project of Sun Yat-sen University (Grant No. 2007023), Distinguished Young Scholar Candidates Programme for The Third Affiliated Hospital of Sun Yat-Sen University, and Pearl River Nova Program of Guangzhou (Grant No. 201610010005). X. Zheng, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Li, PhD, Third Affiliated Hospital of Sun Yat-sen University; X. Li, PhD, Third Affiliated Hospital of Sun Yat-sen University; Y. Zhang, PhD, Third Affiliated Hospital of Sun Yat-sen University; X. Wu, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Wei, BD, Third Affiliated Hospital of Sun Yat-sen University; S. Cao, BD, Third Affiliated Hospital of Sun Yat-sen University; M. Yang, PhD, Third Affiliated Hospital of Sun Yat-sen University; Z. Lin, PhD, Third Affiliated Hospital of Sun Yat-sen University; Z. Liao, PhD, Third Affiliated Hospital of Sun Yat-sen University; J. Qi, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Lv, PhD, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University; L. Wang, MD, Human Genetics, Genome Institute of Singapore, A*STAR; Y. Li, PhD, Human Genetics, Genome Institute of Singapore, A*STAR, and The Jackson Laboratory; A. Irwanto, PhD, Human Genetics, Genome Institute of Singapore, A*STAR; C. Cheng, PhD, SERI, Singapore National Eye Centre, Ophthalmology and Visual Sciences, Eye ACP, Duke-NUS Medical School, Department of Ophthalmology, Yong Loo Lin School of Medicine; X. Chai, PhD, SERI, Singapore National Eye Centre; C. Khor, PhD, Human Genetics, Genome Institute of Singapore, A*STAR; C. Heng, PhD, Department of Pediatrics, Yong Loo Lin School of Medicine, Khoo Teck Puat–National University Children’s Medical Institute, National University Health System; W. Koh, PhD, Saw Swee Hock School of Public Health, NUS, Health Systems and Services Research, Duke-NUS Medical School; J. Yuan, PhD, Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh; J. Bei, PhD, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center; F. Zhang, PhD, Shandong Provincial Institute of Dermatology and Venereology and Hospital for Skin Diseases, Shandong First Medical University and Shandong Academy of Medical Sciences; X. Zhang, PhD, Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University, Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University); Y. Zeng, PhD, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center; Y. Shen, PhD, National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College; J. Liu, PhD, Human Genetics, Genome Institute of Singapore, A*STAR, The Third Affiliated Hospital of Sun Yat-sen University; J. Gu, MD, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University. J. Liu and J. Gu jointly directed this work. X. Zheng and Q. Li contributed equally to this study. Address correspondence to Prof. J. Gu, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China; e-mail: gujieruo@163.com; or Prof. J. Liu, Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138672; e-mail: liuj3@gis.a-star.edu.sg. Accepted for publication August 23, 2019.
Jun Qi
From the Department of Rheumatology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore; The Jackson Laboratory, Farmington, Connecticut, USA; the Singapore Eye Research Institute (SERI); the Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), the Health Systems and Services Research, Duke–National University of Singapore (NUS) Medical School; Departments of Ophthalmology and Pediatrics, Yong Loo Lin School of Medicine; the Khoo Teck Puat–National University Children’s Medical Institute; the Saw Swee Hock School of Public Health, National University of Singapore, Singapore; the division of Cancer Control and Population Sciences, University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou; Shandong Provincial Institute of Dermatology and Venereology and Hospital for Skin Diseases, Shandong First Medical University and Shandong Academy of Medical Sciences; National Clinical Key Project of Dermatology and Venereology, Jinan, Shandong; Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University, Guangzhou; Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University; Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University), Hefei; National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, and Peking Union Medical College, Beijing, China. This study was supported by the Science and Technology Planning Project of Guangdong Province, China (2016A020216013), Guangdong Natural Science Funds for Distinguished Young Scholars (Grant No. 2014A030306039), the Municipal Healthcare Joint-Innovation Major Project of Guangzhou and High-level Personnel of Special Support Program for Technology Innovative Talents and the Top Young of Guangdong Province (Grant No. 2015TQ01R516), the National Supercomputer Center in Guangzhou and the Agency of Science, Technology and Research (A*STAR) of Singapore, the HUJ-CREATE Programme of the National Research Foundation, Singapore (Project Number 370062002), the US National Institutes of Health (Grant Numbers R01CA144034 and UM1 CA182876), the Singapore National Medical Research Council (Grant Number 1270/2010), the 5010 Project of Sun Yat-sen University (Grant No. 2007023), Distinguished Young Scholar Candidates Programme for The Third Affiliated Hospital of Sun Yat-Sen University, and Pearl River Nova Program of Guangzhou (Grant No. 201610010005). X. Zheng, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Li, PhD, Third Affiliated Hospital of Sun Yat-sen University; X. Li, PhD, Third Affiliated Hospital of Sun Yat-sen University; Y. Zhang, PhD, Third Affiliated Hospital of Sun Yat-sen University; X. Wu, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Wei, BD, Third Affiliated Hospital of Sun Yat-sen University; S. Cao, BD, Third Affiliated Hospital of Sun Yat-sen University; M. Yang, PhD, Third Affiliated Hospital of Sun Yat-sen University; Z. Lin, PhD, Third Affiliated Hospital of Sun Yat-sen University; Z. Liao, PhD, Third Affiliated Hospital of Sun Yat-sen University; J. Qi, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Lv, PhD, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University; L. Wang, MD, Human Genetics, Genome Institute of Singapore, A*STAR; Y. Li, PhD, Human Genetics, Genome Institute of Singapore, A*STAR, and The Jackson Laboratory; A. Irwanto, PhD, Human Genetics, Genome Institute of Singapore, A*STAR; C. Cheng, PhD, SERI, Singapore National Eye Centre, Ophthalmology and Visual Sciences, Eye ACP, Duke-NUS Medical School, Department of Ophthalmology, Yong Loo Lin School of Medicine; X. Chai, PhD, SERI, Singapore National Eye Centre; C. Khor, PhD, Human Genetics, Genome Institute of Singapore, A*STAR; C. Heng, PhD, Department of Pediatrics, Yong Loo Lin School of Medicine, Khoo Teck Puat–National University Children’s Medical Institute, National University Health System; W. Koh, PhD, Saw Swee Hock School of Public Health, NUS, Health Systems and Services Research, Duke-NUS Medical School; J. Yuan, PhD, Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh; J. Bei, PhD, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center; F. Zhang, PhD, Shandong Provincial Institute of Dermatology and Venereology and Hospital for Skin Diseases, Shandong First Medical University and Shandong Academy of Medical Sciences; X. Zhang, PhD, Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University, Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University); Y. Zeng, PhD, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center; Y. Shen, PhD, National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College; J. Liu, PhD, Human Genetics, Genome Institute of Singapore, A*STAR, The Third Affiliated Hospital of Sun Yat-sen University; J. Gu, MD, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University. J. Liu and J. Gu jointly directed this work. X. Zheng and Q. Li contributed equally to this study. Address correspondence to Prof. J. Gu, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China; e-mail: gujieruo@163.com; or Prof. J. Liu, Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138672; e-mail: liuj3@gis.a-star.edu.sg. Accepted for publication August 23, 2019.
Qing Lv
From the Department of Rheumatology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore; The Jackson Laboratory, Farmington, Connecticut, USA; the Singapore Eye Research Institute (SERI); the Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), the Health Systems and Services Research, Duke–National University of Singapore (NUS) Medical School; Departments of Ophthalmology and Pediatrics, Yong Loo Lin School of Medicine; the Khoo Teck Puat–National University Children’s Medical Institute; the Saw Swee Hock School of Public Health, National University of Singapore, Singapore; the division of Cancer Control and Population Sciences, University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou; Shandong Provincial Institute of Dermatology and Venereology and Hospital for Skin Diseases, Shandong First Medical University and Shandong Academy of Medical Sciences; National Clinical Key Project of Dermatology and Venereology, Jinan, Shandong; Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University, Guangzhou; Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University; Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University), Hefei; National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, and Peking Union Medical College, Beijing, China. This study was supported by the Science and Technology Planning Project of Guangdong Province, China (2016A020216013), Guangdong Natural Science Funds for Distinguished Young Scholars (Grant No. 2014A030306039), the Municipal Healthcare Joint-Innovation Major Project of Guangzhou and High-level Personnel of Special Support Program for Technology Innovative Talents and the Top Young of Guangdong Province (Grant No. 2015TQ01R516), the National Supercomputer Center in Guangzhou and the Agency of Science, Technology and Research (A*STAR) of Singapore, the HUJ-CREATE Programme of the National Research Foundation, Singapore (Project Number 370062002), the US National Institutes of Health (Grant Numbers R01CA144034 and UM1 CA182876), the Singapore National Medical Research Council (Grant Number 1270/2010), the 5010 Project of Sun Yat-sen University (Grant No. 2007023), Distinguished Young Scholar Candidates Programme for The Third Affiliated Hospital of Sun Yat-Sen University, and Pearl River Nova Program of Guangzhou (Grant No. 201610010005). X. Zheng, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Li, PhD, Third Affiliated Hospital of Sun Yat-sen University; X. Li, PhD, Third Affiliated Hospital of Sun Yat-sen University; Y. Zhang, PhD, Third Affiliated Hospital of Sun Yat-sen University; X. Wu, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Wei, BD, Third Affiliated Hospital of Sun Yat-sen University; S. Cao, BD, Third Affiliated Hospital of Sun Yat-sen University; M. Yang, PhD, Third Affiliated Hospital of Sun Yat-sen University; Z. Lin, PhD, Third Affiliated Hospital of Sun Yat-sen University; Z. Liao, PhD, Third Affiliated Hospital of Sun Yat-sen University; J. Qi, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Lv, PhD, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University; L. Wang, MD, Human Genetics, Genome Institute of Singapore, A*STAR; Y. Li, PhD, Human Genetics, Genome Institute of Singapore, A*STAR, and The Jackson Laboratory; A. Irwanto, PhD, Human Genetics, Genome Institute of Singapore, A*STAR; C. Cheng, PhD, SERI, Singapore National Eye Centre, Ophthalmology and Visual Sciences, Eye ACP, Duke-NUS Medical School, Department of Ophthalmology, Yong Loo Lin School of Medicine; X. Chai, PhD, SERI, Singapore National Eye Centre; C. Khor, PhD, Human Genetics, Genome Institute of Singapore, A*STAR; C. Heng, PhD, Department of Pediatrics, Yong Loo Lin School of Medicine, Khoo Teck Puat–National University Children’s Medical Institute, National University Health System; W. Koh, PhD, Saw Swee Hock School of Public Health, NUS, Health Systems and Services Research, Duke-NUS Medical School; J. Yuan, PhD, Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh; J. Bei, PhD, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center; F. Zhang, PhD, Shandong Provincial Institute of Dermatology and Venereology and Hospital for Skin Diseases, Shandong First Medical University and Shandong Academy of Medical Sciences; X. Zhang, PhD, Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University, Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University); Y. Zeng, PhD, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center; Y. Shen, PhD, National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College; J. Liu, PhD, Human Genetics, Genome Institute of Singapore, A*STAR, The Third Affiliated Hospital of Sun Yat-sen University; J. Gu, MD, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University. J. Liu and J. Gu jointly directed this work. X. Zheng and Q. Li contributed equally to this study. Address correspondence to Prof. J. Gu, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China; e-mail: gujieruo@163.com; or Prof. J. Liu, Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138672; e-mail: liuj3@gis.a-star.edu.sg. Accepted for publication August 23, 2019.
Ling Wang
From the Department of Rheumatology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore; The Jackson Laboratory, Farmington, Connecticut, USA; the Singapore Eye Research Institute (SERI); the Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), the Health Systems and Services Research, Duke–National University of Singapore (NUS) Medical School; Departments of Ophthalmology and Pediatrics, Yong Loo Lin School of Medicine; the Khoo Teck Puat–National University Children’s Medical Institute; the Saw Swee Hock School of Public Health, National University of Singapore, Singapore; the division of Cancer Control and Population Sciences, University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou; Shandong Provincial Institute of Dermatology and Venereology and Hospital for Skin Diseases, Shandong First Medical University and Shandong Academy of Medical Sciences; National Clinical Key Project of Dermatology and Venereology, Jinan, Shandong; Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University, Guangzhou; Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University; Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University), Hefei; National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, and Peking Union Medical College, Beijing, China. This study was supported by the Science and Technology Planning Project of Guangdong Province, China (2016A020216013), Guangdong Natural Science Funds for Distinguished Young Scholars (Grant No. 2014A030306039), the Municipal Healthcare Joint-Innovation Major Project of Guangzhou and High-level Personnel of Special Support Program for Technology Innovative Talents and the Top Young of Guangdong Province (Grant No. 2015TQ01R516), the National Supercomputer Center in Guangzhou and the Agency of Science, Technology and Research (A*STAR) of Singapore, the HUJ-CREATE Programme of the National Research Foundation, Singapore (Project Number 370062002), the US National Institutes of Health (Grant Numbers R01CA144034 and UM1 CA182876), the Singapore National Medical Research Council (Grant Number 1270/2010), the 5010 Project of Sun Yat-sen University (Grant No. 2007023), Distinguished Young Scholar Candidates Programme for The Third Affiliated Hospital of Sun Yat-Sen University, and Pearl River Nova Program of Guangzhou (Grant No. 201610010005). X. Zheng, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Li, PhD, Third Affiliated Hospital of Sun Yat-sen University; X. Li, PhD, Third Affiliated Hospital of Sun Yat-sen University; Y. Zhang, PhD, Third Affiliated Hospital of Sun Yat-sen University; X. Wu, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Wei, BD, Third Affiliated Hospital of Sun Yat-sen University; S. Cao, BD, Third Affiliated Hospital of Sun Yat-sen University; M. Yang, PhD, Third Affiliated Hospital of Sun Yat-sen University; Z. Lin, PhD, Third Affiliated Hospital of Sun Yat-sen University; Z. Liao, PhD, Third Affiliated Hospital of Sun Yat-sen University; J. Qi, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Lv, PhD, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University; L. Wang, MD, Human Genetics, Genome Institute of Singapore, A*STAR; Y. Li, PhD, Human Genetics, Genome Institute of Singapore, A*STAR, and The Jackson Laboratory; A. Irwanto, PhD, Human Genetics, Genome Institute of Singapore, A*STAR; C. Cheng, PhD, SERI, Singapore National Eye Centre, Ophthalmology and Visual Sciences, Eye ACP, Duke-NUS Medical School, Department of Ophthalmology, Yong Loo Lin School of Medicine; X. Chai, PhD, SERI, Singapore National Eye Centre; C. Khor, PhD, Human Genetics, Genome Institute of Singapore, A*STAR; C. Heng, PhD, Department of Pediatrics, Yong Loo Lin School of Medicine, Khoo Teck Puat–National University Children’s Medical Institute, National University Health System; W. Koh, PhD, Saw Swee Hock School of Public Health, NUS, Health Systems and Services Research, Duke-NUS Medical School; J. Yuan, PhD, Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh; J. Bei, PhD, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center; F. Zhang, PhD, Shandong Provincial Institute of Dermatology and Venereology and Hospital for Skin Diseases, Shandong First Medical University and Shandong Academy of Medical Sciences; X. Zhang, PhD, Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University, Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University); Y. Zeng, PhD, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center; Y. Shen, PhD, National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College; J. Liu, PhD, Human Genetics, Genome Institute of Singapore, A*STAR, The Third Affiliated Hospital of Sun Yat-sen University; J. Gu, MD, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University. J. Liu and J. Gu jointly directed this work. X. Zheng and Q. Li contributed equally to this study. Address correspondence to Prof. J. Gu, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China; e-mail: gujieruo@163.com; or Prof. J. Liu, Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138672; e-mail: liuj3@gis.a-star.edu.sg. Accepted for publication August 23, 2019.
Yi Li
From the Department of Rheumatology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore; The Jackson Laboratory, Farmington, Connecticut, USA; the Singapore Eye Research Institute (SERI); the Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), the Health Systems and Services Research, Duke–National University of Singapore (NUS) Medical School; Departments of Ophthalmology and Pediatrics, Yong Loo Lin School of Medicine; the Khoo Teck Puat–National University Children’s Medical Institute; the Saw Swee Hock School of Public Health, National University of Singapore, Singapore; the division of Cancer Control and Population Sciences, University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou; Shandong Provincial Institute of Dermatology and Venereology and Hospital for Skin Diseases, Shandong First Medical University and Shandong Academy of Medical Sciences; National Clinical Key Project of Dermatology and Venereology, Jinan, Shandong; Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University, Guangzhou; Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University; Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University), Hefei; National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, and Peking Union Medical College, Beijing, China. This study was supported by the Science and Technology Planning Project of Guangdong Province, China (2016A020216013), Guangdong Natural Science Funds for Distinguished Young Scholars (Grant No. 2014A030306039), the Municipal Healthcare Joint-Innovation Major Project of Guangzhou and High-level Personnel of Special Support Program for Technology Innovative Talents and the Top Young of Guangdong Province (Grant No. 2015TQ01R516), the National Supercomputer Center in Guangzhou and the Agency of Science, Technology and Research (A*STAR) of Singapore, the HUJ-CREATE Programme of the National Research Foundation, Singapore (Project Number 370062002), the US National Institutes of Health (Grant Numbers R01CA144034 and UM1 CA182876), the Singapore National Medical Research Council (Grant Number 1270/2010), the 5010 Project of Sun Yat-sen University (Grant No. 2007023), Distinguished Young Scholar Candidates Programme for The Third Affiliated Hospital of Sun Yat-Sen University, and Pearl River Nova Program of Guangzhou (Grant No. 201610010005). X. Zheng, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Li, PhD, Third Affiliated Hospital of Sun Yat-sen University; X. Li, PhD, Third Affiliated Hospital of Sun Yat-sen University; Y. Zhang, PhD, Third Affiliated Hospital of Sun Yat-sen University; X. Wu, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Wei, BD, Third Affiliated Hospital of Sun Yat-sen University; S. Cao, BD, Third Affiliated Hospital of Sun Yat-sen University; M. Yang, PhD, Third Affiliated Hospital of Sun Yat-sen University; Z. Lin, PhD, Third Affiliated Hospital of Sun Yat-sen University; Z. Liao, PhD, Third Affiliated Hospital of Sun Yat-sen University; J. Qi, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Lv, PhD, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University; L. Wang, MD, Human Genetics, Genome Institute of Singapore, A*STAR; Y. Li, PhD, Human Genetics, Genome Institute of Singapore, A*STAR, and The Jackson Laboratory; A. Irwanto, PhD, Human Genetics, Genome Institute of Singapore, A*STAR; C. Cheng, PhD, SERI, Singapore National Eye Centre, Ophthalmology and Visual Sciences, Eye ACP, Duke-NUS Medical School, Department of Ophthalmology, Yong Loo Lin School of Medicine; X. Chai, PhD, SERI, Singapore National Eye Centre; C. Khor, PhD, Human Genetics, Genome Institute of Singapore, A*STAR; C. Heng, PhD, Department of Pediatrics, Yong Loo Lin School of Medicine, Khoo Teck Puat–National University Children’s Medical Institute, National University Health System; W. Koh, PhD, Saw Swee Hock School of Public Health, NUS, Health Systems and Services Research, Duke-NUS Medical School; J. Yuan, PhD, Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh; J. Bei, PhD, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center; F. Zhang, PhD, Shandong Provincial Institute of Dermatology and Venereology and Hospital for Skin Diseases, Shandong First Medical University and Shandong Academy of Medical Sciences; X. Zhang, PhD, Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University, Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University); Y. Zeng, PhD, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center; Y. Shen, PhD, National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College; J. Liu, PhD, Human Genetics, Genome Institute of Singapore, A*STAR, The Third Affiliated Hospital of Sun Yat-sen University; J. Gu, MD, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University. J. Liu and J. Gu jointly directed this work. X. Zheng and Q. Li contributed equally to this study. Address correspondence to Prof. J. Gu, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China; e-mail: gujieruo@163.com; or Prof. J. Liu, Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138672; e-mail: liuj3@gis.a-star.edu.sg. Accepted for publication August 23, 2019.
Astrid Irwanto
From the Department of Rheumatology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore; The Jackson Laboratory, Farmington, Connecticut, USA; the Singapore Eye Research Institute (SERI); the Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), the Health Systems and Services Research, Duke–National University of Singapore (NUS) Medical School; Departments of Ophthalmology and Pediatrics, Yong Loo Lin School of Medicine; the Khoo Teck Puat–National University Children’s Medical Institute; the Saw Swee Hock School of Public Health, National University of Singapore, Singapore; the division of Cancer Control and Population Sciences, University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou; Shandong Provincial Institute of Dermatology and Venereology and Hospital for Skin Diseases, Shandong First Medical University and Shandong Academy of Medical Sciences; National Clinical Key Project of Dermatology and Venereology, Jinan, Shandong; Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University, Guangzhou; Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University; Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University), Hefei; National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, and Peking Union Medical College, Beijing, China. This study was supported by the Science and Technology Planning Project of Guangdong Province, China (2016A020216013), Guangdong Natural Science Funds for Distinguished Young Scholars (Grant No. 2014A030306039), the Municipal Healthcare Joint-Innovation Major Project of Guangzhou and High-level Personnel of Special Support Program for Technology Innovative Talents and the Top Young of Guangdong Province (Grant No. 2015TQ01R516), the National Supercomputer Center in Guangzhou and the Agency of Science, Technology and Research (A*STAR) of Singapore, the HUJ-CREATE Programme of the National Research Foundation, Singapore (Project Number 370062002), the US National Institutes of Health (Grant Numbers R01CA144034 and UM1 CA182876), the Singapore National Medical Research Council (Grant Number 1270/2010), the 5010 Project of Sun Yat-sen University (Grant No. 2007023), Distinguished Young Scholar Candidates Programme for The Third Affiliated Hospital of Sun Yat-Sen University, and Pearl River Nova Program of Guangzhou (Grant No. 201610010005). X. Zheng, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Li, PhD, Third Affiliated Hospital of Sun Yat-sen University; X. Li, PhD, Third Affiliated Hospital of Sun Yat-sen University; Y. Zhang, PhD, Third Affiliated Hospital of Sun Yat-sen University; X. Wu, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Wei, BD, Third Affiliated Hospital of Sun Yat-sen University; S. Cao, BD, Third Affiliated Hospital of Sun Yat-sen University; M. Yang, PhD, Third Affiliated Hospital of Sun Yat-sen University; Z. Lin, PhD, Third Affiliated Hospital of Sun Yat-sen University; Z. Liao, PhD, Third Affiliated Hospital of Sun Yat-sen University; J. Qi, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Lv, PhD, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University; L. Wang, MD, Human Genetics, Genome Institute of Singapore, A*STAR; Y. Li, PhD, Human Genetics, Genome Institute of Singapore, A*STAR, and The Jackson Laboratory; A. Irwanto, PhD, Human Genetics, Genome Institute of Singapore, A*STAR; C. Cheng, PhD, SERI, Singapore National Eye Centre, Ophthalmology and Visual Sciences, Eye ACP, Duke-NUS Medical School, Department of Ophthalmology, Yong Loo Lin School of Medicine; X. Chai, PhD, SERI, Singapore National Eye Centre; C. Khor, PhD, Human Genetics, Genome Institute of Singapore, A*STAR; C. Heng, PhD, Department of Pediatrics, Yong Loo Lin School of Medicine, Khoo Teck Puat–National University Children’s Medical Institute, National University Health System; W. Koh, PhD, Saw Swee Hock School of Public Health, NUS, Health Systems and Services Research, Duke-NUS Medical School; J. Yuan, PhD, Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh; J. Bei, PhD, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center; F. Zhang, PhD, Shandong Provincial Institute of Dermatology and Venereology and Hospital for Skin Diseases, Shandong First Medical University and Shandong Academy of Medical Sciences; X. Zhang, PhD, Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University, Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University); Y. Zeng, PhD, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center; Y. Shen, PhD, National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College; J. Liu, PhD, Human Genetics, Genome Institute of Singapore, A*STAR, The Third Affiliated Hospital of Sun Yat-sen University; J. Gu, MD, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University. J. Liu and J. Gu jointly directed this work. X. Zheng and Q. Li contributed equally to this study. Address correspondence to Prof. J. Gu, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China; e-mail: gujieruo@163.com; or Prof. J. Liu, Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138672; e-mail: liuj3@gis.a-star.edu.sg. Accepted for publication August 23, 2019.
Ching-Yu Cheng
From the Department of Rheumatology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore; The Jackson Laboratory, Farmington, Connecticut, USA; the Singapore Eye Research Institute (SERI); the Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), the Health Systems and Services Research, Duke–National University of Singapore (NUS) Medical School; Departments of Ophthalmology and Pediatrics, Yong Loo Lin School of Medicine; the Khoo Teck Puat–National University Children’s Medical Institute; the Saw Swee Hock School of Public Health, National University of Singapore, Singapore; the division of Cancer Control and Population Sciences, University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou; Shandong Provincial Institute of Dermatology and Venereology and Hospital for Skin Diseases, Shandong First Medical University and Shandong Academy of Medical Sciences; National Clinical Key Project of Dermatology and Venereology, Jinan, Shandong; Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University, Guangzhou; Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University; Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University), Hefei; National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, and Peking Union Medical College, Beijing, China. This study was supported by the Science and Technology Planning Project of Guangdong Province, China (2016A020216013), Guangdong Natural Science Funds for Distinguished Young Scholars (Grant No. 2014A030306039), the Municipal Healthcare Joint-Innovation Major Project of Guangzhou and High-level Personnel of Special Support Program for Technology Innovative Talents and the Top Young of Guangdong Province (Grant No. 2015TQ01R516), the National Supercomputer Center in Guangzhou and the Agency of Science, Technology and Research (A*STAR) of Singapore, the HUJ-CREATE Programme of the National Research Foundation, Singapore (Project Number 370062002), the US National Institutes of Health (Grant Numbers R01CA144034 and UM1 CA182876), the Singapore National Medical Research Council (Grant Number 1270/2010), the 5010 Project of Sun Yat-sen University (Grant No. 2007023), Distinguished Young Scholar Candidates Programme for The Third Affiliated Hospital of Sun Yat-Sen University, and Pearl River Nova Program of Guangzhou (Grant No. 201610010005). X. Zheng, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Li, PhD, Third Affiliated Hospital of Sun Yat-sen University; X. Li, PhD, Third Affiliated Hospital of Sun Yat-sen University; Y. Zhang, PhD, Third Affiliated Hospital of Sun Yat-sen University; X. Wu, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Wei, BD, Third Affiliated Hospital of Sun Yat-sen University; S. Cao, BD, Third Affiliated Hospital of Sun Yat-sen University; M. Yang, PhD, Third Affiliated Hospital of Sun Yat-sen University; Z. Lin, PhD, Third Affiliated Hospital of Sun Yat-sen University; Z. Liao, PhD, Third Affiliated Hospital of Sun Yat-sen University; J. Qi, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Lv, PhD, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University; L. Wang, MD, Human Genetics, Genome Institute of Singapore, A*STAR; Y. Li, PhD, Human Genetics, Genome Institute of Singapore, A*STAR, and The Jackson Laboratory; A. Irwanto, PhD, Human Genetics, Genome Institute of Singapore, A*STAR; C. Cheng, PhD, SERI, Singapore National Eye Centre, Ophthalmology and Visual Sciences, Eye ACP, Duke-NUS Medical School, Department of Ophthalmology, Yong Loo Lin School of Medicine; X. Chai, PhD, SERI, Singapore National Eye Centre; C. Khor, PhD, Human Genetics, Genome Institute of Singapore, A*STAR; C. Heng, PhD, Department of Pediatrics, Yong Loo Lin School of Medicine, Khoo Teck Puat–National University Children’s Medical Institute, National University Health System; W. Koh, PhD, Saw Swee Hock School of Public Health, NUS, Health Systems and Services Research, Duke-NUS Medical School; J. Yuan, PhD, Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh; J. Bei, PhD, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center; F. Zhang, PhD, Shandong Provincial Institute of Dermatology and Venereology and Hospital for Skin Diseases, Shandong First Medical University and Shandong Academy of Medical Sciences; X. Zhang, PhD, Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University, Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University); Y. Zeng, PhD, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center; Y. Shen, PhD, National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College; J. Liu, PhD, Human Genetics, Genome Institute of Singapore, A*STAR, The Third Affiliated Hospital of Sun Yat-sen University; J. Gu, MD, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University. J. Liu and J. Gu jointly directed this work. X. Zheng and Q. Li contributed equally to this study. Address correspondence to Prof. J. Gu, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China; e-mail: gujieruo@163.com; or Prof. J. Liu, Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138672; e-mail: liuj3@gis.a-star.edu.sg. Accepted for publication August 23, 2019.
Xiaoran Chai
From the Department of Rheumatology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore; The Jackson Laboratory, Farmington, Connecticut, USA; the Singapore Eye Research Institute (SERI); the Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), the Health Systems and Services Research, Duke–National University of Singapore (NUS) Medical School; Departments of Ophthalmology and Pediatrics, Yong Loo Lin School of Medicine; the Khoo Teck Puat–National University Children’s Medical Institute; the Saw Swee Hock School of Public Health, National University of Singapore, Singapore; the division of Cancer Control and Population Sciences, University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou; Shandong Provincial Institute of Dermatology and Venereology and Hospital for Skin Diseases, Shandong First Medical University and Shandong Academy of Medical Sciences; National Clinical Key Project of Dermatology and Venereology, Jinan, Shandong; Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University, Guangzhou; Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University; Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University), Hefei; National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, and Peking Union Medical College, Beijing, China. This study was supported by the Science and Technology Planning Project of Guangdong Province, China (2016A020216013), Guangdong Natural Science Funds for Distinguished Young Scholars (Grant No. 2014A030306039), the Municipal Healthcare Joint-Innovation Major Project of Guangzhou and High-level Personnel of Special Support Program for Technology Innovative Talents and the Top Young of Guangdong Province (Grant No. 2015TQ01R516), the National Supercomputer Center in Guangzhou and the Agency of Science, Technology and Research (A*STAR) of Singapore, the HUJ-CREATE Programme of the National Research Foundation, Singapore (Project Number 370062002), the US National Institutes of Health (Grant Numbers R01CA144034 and UM1 CA182876), the Singapore National Medical Research Council (Grant Number 1270/2010), the 5010 Project of Sun Yat-sen University (Grant No. 2007023), Distinguished Young Scholar Candidates Programme for The Third Affiliated Hospital of Sun Yat-Sen University, and Pearl River Nova Program of Guangzhou (Grant No. 201610010005). X. Zheng, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Li, PhD, Third Affiliated Hospital of Sun Yat-sen University; X. Li, PhD, Third Affiliated Hospital of Sun Yat-sen University; Y. Zhang, PhD, Third Affiliated Hospital of Sun Yat-sen University; X. Wu, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Wei, BD, Third Affiliated Hospital of Sun Yat-sen University; S. Cao, BD, Third Affiliated Hospital of Sun Yat-sen University; M. Yang, PhD, Third Affiliated Hospital of Sun Yat-sen University; Z. Lin, PhD, Third Affiliated Hospital of Sun Yat-sen University; Z. Liao, PhD, Third Affiliated Hospital of Sun Yat-sen University; J. Qi, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Lv, PhD, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University; L. Wang, MD, Human Genetics, Genome Institute of Singapore, A*STAR; Y. Li, PhD, Human Genetics, Genome Institute of Singapore, A*STAR, and The Jackson Laboratory; A. Irwanto, PhD, Human Genetics, Genome Institute of Singapore, A*STAR; C. Cheng, PhD, SERI, Singapore National Eye Centre, Ophthalmology and Visual Sciences, Eye ACP, Duke-NUS Medical School, Department of Ophthalmology, Yong Loo Lin School of Medicine; X. Chai, PhD, SERI, Singapore National Eye Centre; C. Khor, PhD, Human Genetics, Genome Institute of Singapore, A*STAR; C. Heng, PhD, Department of Pediatrics, Yong Loo Lin School of Medicine, Khoo Teck Puat–National University Children’s Medical Institute, National University Health System; W. Koh, PhD, Saw Swee Hock School of Public Health, NUS, Health Systems and Services Research, Duke-NUS Medical School; J. Yuan, PhD, Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh; J. Bei, PhD, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center; F. Zhang, PhD, Shandong Provincial Institute of Dermatology and Venereology and Hospital for Skin Diseases, Shandong First Medical University and Shandong Academy of Medical Sciences; X. Zhang, PhD, Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University, Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University); Y. Zeng, PhD, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center; Y. Shen, PhD, National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College; J. Liu, PhD, Human Genetics, Genome Institute of Singapore, A*STAR, The Third Affiliated Hospital of Sun Yat-sen University; J. Gu, MD, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University. J. Liu and J. Gu jointly directed this work. X. Zheng and Q. Li contributed equally to this study. Address correspondence to Prof. J. Gu, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China; e-mail: gujieruo@163.com; or Prof. J. Liu, Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138672; e-mail: liuj3@gis.a-star.edu.sg. Accepted for publication August 23, 2019.
Chiea Chuen Khor
From the Department of Rheumatology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore; The Jackson Laboratory, Farmington, Connecticut, USA; the Singapore Eye Research Institute (SERI); the Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), the Health Systems and Services Research, Duke–National University of Singapore (NUS) Medical School; Departments of Ophthalmology and Pediatrics, Yong Loo Lin School of Medicine; the Khoo Teck Puat–National University Children’s Medical Institute; the Saw Swee Hock School of Public Health, National University of Singapore, Singapore; the division of Cancer Control and Population Sciences, University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou; Shandong Provincial Institute of Dermatology and Venereology and Hospital for Skin Diseases, Shandong First Medical University and Shandong Academy of Medical Sciences; National Clinical Key Project of Dermatology and Venereology, Jinan, Shandong; Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University, Guangzhou; Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University; Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University), Hefei; National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, and Peking Union Medical College, Beijing, China. This study was supported by the Science and Technology Planning Project of Guangdong Province, China (2016A020216013), Guangdong Natural Science Funds for Distinguished Young Scholars (Grant No. 2014A030306039), the Municipal Healthcare Joint-Innovation Major Project of Guangzhou and High-level Personnel of Special Support Program for Technology Innovative Talents and the Top Young of Guangdong Province (Grant No. 2015TQ01R516), the National Supercomputer Center in Guangzhou and the Agency of Science, Technology and Research (A*STAR) of Singapore, the HUJ-CREATE Programme of the National Research Foundation, Singapore (Project Number 370062002), the US National Institutes of Health (Grant Numbers R01CA144034 and UM1 CA182876), the Singapore National Medical Research Council (Grant Number 1270/2010), the 5010 Project of Sun Yat-sen University (Grant No. 2007023), Distinguished Young Scholar Candidates Programme for The Third Affiliated Hospital of Sun Yat-Sen University, and Pearl River Nova Program of Guangzhou (Grant No. 201610010005). X. Zheng, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Li, PhD, Third Affiliated Hospital of Sun Yat-sen University; X. Li, PhD, Third Affiliated Hospital of Sun Yat-sen University; Y. Zhang, PhD, Third Affiliated Hospital of Sun Yat-sen University; X. Wu, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Wei, BD, Third Affiliated Hospital of Sun Yat-sen University; S. Cao, BD, Third Affiliated Hospital of Sun Yat-sen University; M. Yang, PhD, Third Affiliated Hospital of Sun Yat-sen University; Z. Lin, PhD, Third Affiliated Hospital of Sun Yat-sen University; Z. Liao, PhD, Third Affiliated Hospital of Sun Yat-sen University; J. Qi, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Lv, PhD, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University; L. Wang, MD, Human Genetics, Genome Institute of Singapore, A*STAR; Y. Li, PhD, Human Genetics, Genome Institute of Singapore, A*STAR, and The Jackson Laboratory; A. Irwanto, PhD, Human Genetics, Genome Institute of Singapore, A*STAR; C. Cheng, PhD, SERI, Singapore National Eye Centre, Ophthalmology and Visual Sciences, Eye ACP, Duke-NUS Medical School, Department of Ophthalmology, Yong Loo Lin School of Medicine; X. Chai, PhD, SERI, Singapore National Eye Centre; C. Khor, PhD, Human Genetics, Genome Institute of Singapore, A*STAR; C. Heng, PhD, Department of Pediatrics, Yong Loo Lin School of Medicine, Khoo Teck Puat–National University Children’s Medical Institute, National University Health System; W. Koh, PhD, Saw Swee Hock School of Public Health, NUS, Health Systems and Services Research, Duke-NUS Medical School; J. Yuan, PhD, Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh; J. Bei, PhD, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center; F. Zhang, PhD, Shandong Provincial Institute of Dermatology and Venereology and Hospital for Skin Diseases, Shandong First Medical University and Shandong Academy of Medical Sciences; X. Zhang, PhD, Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University, Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University); Y. Zeng, PhD, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center; Y. Shen, PhD, National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College; J. Liu, PhD, Human Genetics, Genome Institute of Singapore, A*STAR, The Third Affiliated Hospital of Sun Yat-sen University; J. Gu, MD, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University. J. Liu and J. Gu jointly directed this work. X. Zheng and Q. Li contributed equally to this study. Address correspondence to Prof. J. Gu, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China; e-mail: gujieruo@163.com; or Prof. J. Liu, Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138672; e-mail: liuj3@gis.a-star.edu.sg. Accepted for publication August 23, 2019.
Chew-Kiat Heng
From the Department of Rheumatology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore; The Jackson Laboratory, Farmington, Connecticut, USA; the Singapore Eye Research Institute (SERI); the Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), the Health Systems and Services Research, Duke–National University of Singapore (NUS) Medical School; Departments of Ophthalmology and Pediatrics, Yong Loo Lin School of Medicine; the Khoo Teck Puat–National University Children’s Medical Institute; the Saw Swee Hock School of Public Health, National University of Singapore, Singapore; the division of Cancer Control and Population Sciences, University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou; Shandong Provincial Institute of Dermatology and Venereology and Hospital for Skin Diseases, Shandong First Medical University and Shandong Academy of Medical Sciences; National Clinical Key Project of Dermatology and Venereology, Jinan, Shandong; Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University, Guangzhou; Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University; Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University), Hefei; National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, and Peking Union Medical College, Beijing, China. This study was supported by the Science and Technology Planning Project of Guangdong Province, China (2016A020216013), Guangdong Natural Science Funds for Distinguished Young Scholars (Grant No. 2014A030306039), the Municipal Healthcare Joint-Innovation Major Project of Guangzhou and High-level Personnel of Special Support Program for Technology Innovative Talents and the Top Young of Guangdong Province (Grant No. 2015TQ01R516), the National Supercomputer Center in Guangzhou and the Agency of Science, Technology and Research (A*STAR) of Singapore, the HUJ-CREATE Programme of the National Research Foundation, Singapore (Project Number 370062002), the US National Institutes of Health (Grant Numbers R01CA144034 and UM1 CA182876), the Singapore National Medical Research Council (Grant Number 1270/2010), the 5010 Project of Sun Yat-sen University (Grant No. 2007023), Distinguished Young Scholar Candidates Programme for The Third Affiliated Hospital of Sun Yat-Sen University, and Pearl River Nova Program of Guangzhou (Grant No. 201610010005). X. Zheng, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Li, PhD, Third Affiliated Hospital of Sun Yat-sen University; X. Li, PhD, Third Affiliated Hospital of Sun Yat-sen University; Y. Zhang, PhD, Third Affiliated Hospital of Sun Yat-sen University; X. Wu, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Wei, BD, Third Affiliated Hospital of Sun Yat-sen University; S. Cao, BD, Third Affiliated Hospital of Sun Yat-sen University; M. Yang, PhD, Third Affiliated Hospital of Sun Yat-sen University; Z. Lin, PhD, Third Affiliated Hospital of Sun Yat-sen University; Z. Liao, PhD, Third Affiliated Hospital of Sun Yat-sen University; J. Qi, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Lv, PhD, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University; L. Wang, MD, Human Genetics, Genome Institute of Singapore, A*STAR; Y. Li, PhD, Human Genetics, Genome Institute of Singapore, A*STAR, and The Jackson Laboratory; A. Irwanto, PhD, Human Genetics, Genome Institute of Singapore, A*STAR; C. Cheng, PhD, SERI, Singapore National Eye Centre, Ophthalmology and Visual Sciences, Eye ACP, Duke-NUS Medical School, Department of Ophthalmology, Yong Loo Lin School of Medicine; X. Chai, PhD, SERI, Singapore National Eye Centre; C. Khor, PhD, Human Genetics, Genome Institute of Singapore, A*STAR; C. Heng, PhD, Department of Pediatrics, Yong Loo Lin School of Medicine, Khoo Teck Puat–National University Children’s Medical Institute, National University Health System; W. Koh, PhD, Saw Swee Hock School of Public Health, NUS, Health Systems and Services Research, Duke-NUS Medical School; J. Yuan, PhD, Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh; J. Bei, PhD, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center; F. Zhang, PhD, Shandong Provincial Institute of Dermatology and Venereology and Hospital for Skin Diseases, Shandong First Medical University and Shandong Academy of Medical Sciences; X. Zhang, PhD, Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University, Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University); Y. Zeng, PhD, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center; Y. Shen, PhD, National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College; J. Liu, PhD, Human Genetics, Genome Institute of Singapore, A*STAR, The Third Affiliated Hospital of Sun Yat-sen University; J. Gu, MD, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University. J. Liu and J. Gu jointly directed this work. X. Zheng and Q. Li contributed equally to this study. Address correspondence to Prof. J. Gu, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China; e-mail: gujieruo@163.com; or Prof. J. Liu, Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138672; e-mail: liuj3@gis.a-star.edu.sg. Accepted for publication August 23, 2019.
Woon-Puay Koh
From the Department of Rheumatology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore; The Jackson Laboratory, Farmington, Connecticut, USA; the Singapore Eye Research Institute (SERI); the Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), the Health Systems and Services Research, Duke–National University of Singapore (NUS) Medical School; Departments of Ophthalmology and Pediatrics, Yong Loo Lin School of Medicine; the Khoo Teck Puat–National University Children’s Medical Institute; the Saw Swee Hock School of Public Health, National University of Singapore, Singapore; the division of Cancer Control and Population Sciences, University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou; Shandong Provincial Institute of Dermatology and Venereology and Hospital for Skin Diseases, Shandong First Medical University and Shandong Academy of Medical Sciences; National Clinical Key Project of Dermatology and Venereology, Jinan, Shandong; Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University, Guangzhou; Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University; Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University), Hefei; National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, and Peking Union Medical College, Beijing, China. This study was supported by the Science and Technology Planning Project of Guangdong Province, China (2016A020216013), Guangdong Natural Science Funds for Distinguished Young Scholars (Grant No. 2014A030306039), the Municipal Healthcare Joint-Innovation Major Project of Guangzhou and High-level Personnel of Special Support Program for Technology Innovative Talents and the Top Young of Guangdong Province (Grant No. 2015TQ01R516), the National Supercomputer Center in Guangzhou and the Agency of Science, Technology and Research (A*STAR) of Singapore, the HUJ-CREATE Programme of the National Research Foundation, Singapore (Project Number 370062002), the US National Institutes of Health (Grant Numbers R01CA144034 and UM1 CA182876), the Singapore National Medical Research Council (Grant Number 1270/2010), the 5010 Project of Sun Yat-sen University (Grant No. 2007023), Distinguished Young Scholar Candidates Programme for The Third Affiliated Hospital of Sun Yat-Sen University, and Pearl River Nova Program of Guangzhou (Grant No. 201610010005). X. Zheng, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Li, PhD, Third Affiliated Hospital of Sun Yat-sen University; X. Li, PhD, Third Affiliated Hospital of Sun Yat-sen University; Y. Zhang, PhD, Third Affiliated Hospital of Sun Yat-sen University; X. Wu, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Wei, BD, Third Affiliated Hospital of Sun Yat-sen University; S. Cao, BD, Third Affiliated Hospital of Sun Yat-sen University; M. Yang, PhD, Third Affiliated Hospital of Sun Yat-sen University; Z. Lin, PhD, Third Affiliated Hospital of Sun Yat-sen University; Z. Liao, PhD, Third Affiliated Hospital of Sun Yat-sen University; J. Qi, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Lv, PhD, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University; L. Wang, MD, Human Genetics, Genome Institute of Singapore, A*STAR; Y. Li, PhD, Human Genetics, Genome Institute of Singapore, A*STAR, and The Jackson Laboratory; A. Irwanto, PhD, Human Genetics, Genome Institute of Singapore, A*STAR; C. Cheng, PhD, SERI, Singapore National Eye Centre, Ophthalmology and Visual Sciences, Eye ACP, Duke-NUS Medical School, Department of Ophthalmology, Yong Loo Lin School of Medicine; X. Chai, PhD, SERI, Singapore National Eye Centre; C. Khor, PhD, Human Genetics, Genome Institute of Singapore, A*STAR; C. Heng, PhD, Department of Pediatrics, Yong Loo Lin School of Medicine, Khoo Teck Puat–National University Children’s Medical Institute, National University Health System; W. Koh, PhD, Saw Swee Hock School of Public Health, NUS, Health Systems and Services Research, Duke-NUS Medical School; J. Yuan, PhD, Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh; J. Bei, PhD, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center; F. Zhang, PhD, Shandong Provincial Institute of Dermatology and Venereology and Hospital for Skin Diseases, Shandong First Medical University and Shandong Academy of Medical Sciences; X. Zhang, PhD, Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University, Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University); Y. Zeng, PhD, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center; Y. Shen, PhD, National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College; J. Liu, PhD, Human Genetics, Genome Institute of Singapore, A*STAR, The Third Affiliated Hospital of Sun Yat-sen University; J. Gu, MD, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University. J. Liu and J. Gu jointly directed this work. X. Zheng and Q. Li contributed equally to this study. Address correspondence to Prof. J. Gu, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China; e-mail: gujieruo@163.com; or Prof. J. Liu, Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138672; e-mail: liuj3@gis.a-star.edu.sg. Accepted for publication August 23, 2019.
Jian-Min Yuan
From the Department of Rheumatology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore; The Jackson Laboratory, Farmington, Connecticut, USA; the Singapore Eye Research Institute (SERI); the Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), the Health Systems and Services Research, Duke–National University of Singapore (NUS) Medical School; Departments of Ophthalmology and Pediatrics, Yong Loo Lin School of Medicine; the Khoo Teck Puat–National University Children’s Medical Institute; the Saw Swee Hock School of Public Health, National University of Singapore, Singapore; the division of Cancer Control and Population Sciences, University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou; Shandong Provincial Institute of Dermatology and Venereology and Hospital for Skin Diseases, Shandong First Medical University and Shandong Academy of Medical Sciences; National Clinical Key Project of Dermatology and Venereology, Jinan, Shandong; Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University, Guangzhou; Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University; Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University), Hefei; National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, and Peking Union Medical College, Beijing, China. This study was supported by the Science and Technology Planning Project of Guangdong Province, China (2016A020216013), Guangdong Natural Science Funds for Distinguished Young Scholars (Grant No. 2014A030306039), the Municipal Healthcare Joint-Innovation Major Project of Guangzhou and High-level Personnel of Special Support Program for Technology Innovative Talents and the Top Young of Guangdong Province (Grant No. 2015TQ01R516), the National Supercomputer Center in Guangzhou and the Agency of Science, Technology and Research (A*STAR) of Singapore, the HUJ-CREATE Programme of the National Research Foundation, Singapore (Project Number 370062002), the US National Institutes of Health (Grant Numbers R01CA144034 and UM1 CA182876), the Singapore National Medical Research Council (Grant Number 1270/2010), the 5010 Project of Sun Yat-sen University (Grant No. 2007023), Distinguished Young Scholar Candidates Programme for The Third Affiliated Hospital of Sun Yat-Sen University, and Pearl River Nova Program of Guangzhou (Grant No. 201610010005). X. Zheng, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Li, PhD, Third Affiliated Hospital of Sun Yat-sen University; X. Li, PhD, Third Affiliated Hospital of Sun Yat-sen University; Y. Zhang, PhD, Third Affiliated Hospital of Sun Yat-sen University; X. Wu, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Wei, BD, Third Affiliated Hospital of Sun Yat-sen University; S. Cao, BD, Third Affiliated Hospital of Sun Yat-sen University; M. Yang, PhD, Third Affiliated Hospital of Sun Yat-sen University; Z. Lin, PhD, Third Affiliated Hospital of Sun Yat-sen University; Z. Liao, PhD, Third Affiliated Hospital of Sun Yat-sen University; J. Qi, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Lv, PhD, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University; L. Wang, MD, Human Genetics, Genome Institute of Singapore, A*STAR; Y. Li, PhD, Human Genetics, Genome Institute of Singapore, A*STAR, and The Jackson Laboratory; A. Irwanto, PhD, Human Genetics, Genome Institute of Singapore, A*STAR; C. Cheng, PhD, SERI, Singapore National Eye Centre, Ophthalmology and Visual Sciences, Eye ACP, Duke-NUS Medical School, Department of Ophthalmology, Yong Loo Lin School of Medicine; X. Chai, PhD, SERI, Singapore National Eye Centre; C. Khor, PhD, Human Genetics, Genome Institute of Singapore, A*STAR; C. Heng, PhD, Department of Pediatrics, Yong Loo Lin School of Medicine, Khoo Teck Puat–National University Children’s Medical Institute, National University Health System; W. Koh, PhD, Saw Swee Hock School of Public Health, NUS, Health Systems and Services Research, Duke-NUS Medical School; J. Yuan, PhD, Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh; J. Bei, PhD, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center; F. Zhang, PhD, Shandong Provincial Institute of Dermatology and Venereology and Hospital for Skin Diseases, Shandong First Medical University and Shandong Academy of Medical Sciences; X. Zhang, PhD, Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University, Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University); Y. Zeng, PhD, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center; Y. Shen, PhD, National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College; J. Liu, PhD, Human Genetics, Genome Institute of Singapore, A*STAR, The Third Affiliated Hospital of Sun Yat-sen University; J. Gu, MD, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University. J. Liu and J. Gu jointly directed this work. X. Zheng and Q. Li contributed equally to this study. Address correspondence to Prof. J. Gu, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China; e-mail: gujieruo@163.com; or Prof. J. Liu, Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138672; e-mail: liuj3@gis.a-star.edu.sg. Accepted for publication August 23, 2019.
Jinxin Bei
From the Department of Rheumatology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore; The Jackson Laboratory, Farmington, Connecticut, USA; the Singapore Eye Research Institute (SERI); the Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), the Health Systems and Services Research, Duke–National University of Singapore (NUS) Medical School; Departments of Ophthalmology and Pediatrics, Yong Loo Lin School of Medicine; the Khoo Teck Puat–National University Children’s Medical Institute; the Saw Swee Hock School of Public Health, National University of Singapore, Singapore; the division of Cancer Control and Population Sciences, University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou; Shandong Provincial Institute of Dermatology and Venereology and Hospital for Skin Diseases, Shandong First Medical University and Shandong Academy of Medical Sciences; National Clinical Key Project of Dermatology and Venereology, Jinan, Shandong; Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University, Guangzhou; Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University; Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University), Hefei; National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, and Peking Union Medical College, Beijing, China. This study was supported by the Science and Technology Planning Project of Guangdong Province, China (2016A020216013), Guangdong Natural Science Funds for Distinguished Young Scholars (Grant No. 2014A030306039), the Municipal Healthcare Joint-Innovation Major Project of Guangzhou and High-level Personnel of Special Support Program for Technology Innovative Talents and the Top Young of Guangdong Province (Grant No. 2015TQ01R516), the National Supercomputer Center in Guangzhou and the Agency of Science, Technology and Research (A*STAR) of Singapore, the HUJ-CREATE Programme of the National Research Foundation, Singapore (Project Number 370062002), the US National Institutes of Health (Grant Numbers R01CA144034 and UM1 CA182876), the Singapore National Medical Research Council (Grant Number 1270/2010), the 5010 Project of Sun Yat-sen University (Grant No. 2007023), Distinguished Young Scholar Candidates Programme for The Third Affiliated Hospital of Sun Yat-Sen University, and Pearl River Nova Program of Guangzhou (Grant No. 201610010005). X. Zheng, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Li, PhD, Third Affiliated Hospital of Sun Yat-sen University; X. Li, PhD, Third Affiliated Hospital of Sun Yat-sen University; Y. Zhang, PhD, Third Affiliated Hospital of Sun Yat-sen University; X. Wu, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Wei, BD, Third Affiliated Hospital of Sun Yat-sen University; S. Cao, BD, Third Affiliated Hospital of Sun Yat-sen University; M. Yang, PhD, Third Affiliated Hospital of Sun Yat-sen University; Z. Lin, PhD, Third Affiliated Hospital of Sun Yat-sen University; Z. Liao, PhD, Third Affiliated Hospital of Sun Yat-sen University; J. Qi, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Lv, PhD, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University; L. Wang, MD, Human Genetics, Genome Institute of Singapore, A*STAR; Y. Li, PhD, Human Genetics, Genome Institute of Singapore, A*STAR, and The Jackson Laboratory; A. Irwanto, PhD, Human Genetics, Genome Institute of Singapore, A*STAR; C. Cheng, PhD, SERI, Singapore National Eye Centre, Ophthalmology and Visual Sciences, Eye ACP, Duke-NUS Medical School, Department of Ophthalmology, Yong Loo Lin School of Medicine; X. Chai, PhD, SERI, Singapore National Eye Centre; C. Khor, PhD, Human Genetics, Genome Institute of Singapore, A*STAR; C. Heng, PhD, Department of Pediatrics, Yong Loo Lin School of Medicine, Khoo Teck Puat–National University Children’s Medical Institute, National University Health System; W. Koh, PhD, Saw Swee Hock School of Public Health, NUS, Health Systems and Services Research, Duke-NUS Medical School; J. Yuan, PhD, Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh; J. Bei, PhD, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center; F. Zhang, PhD, Shandong Provincial Institute of Dermatology and Venereology and Hospital for Skin Diseases, Shandong First Medical University and Shandong Academy of Medical Sciences; X. Zhang, PhD, Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University, Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University); Y. Zeng, PhD, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center; Y. Shen, PhD, National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College; J. Liu, PhD, Human Genetics, Genome Institute of Singapore, A*STAR, The Third Affiliated Hospital of Sun Yat-sen University; J. Gu, MD, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University. J. Liu and J. Gu jointly directed this work. X. Zheng and Q. Li contributed equally to this study. Address correspondence to Prof. J. Gu, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China; e-mail: gujieruo@163.com; or Prof. J. Liu, Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138672; e-mail: liuj3@gis.a-star.edu.sg. Accepted for publication August 23, 2019.
Furen Zhang
From the Department of Rheumatology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore; The Jackson Laboratory, Farmington, Connecticut, USA; the Singapore Eye Research Institute (SERI); the Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), the Health Systems and Services Research, Duke–National University of Singapore (NUS) Medical School; Departments of Ophthalmology and Pediatrics, Yong Loo Lin School of Medicine; the Khoo Teck Puat–National University Children’s Medical Institute; the Saw Swee Hock School of Public Health, National University of Singapore, Singapore; the division of Cancer Control and Population Sciences, University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou; Shandong Provincial Institute of Dermatology and Venereology and Hospital for Skin Diseases, Shandong First Medical University and Shandong Academy of Medical Sciences; National Clinical Key Project of Dermatology and Venereology, Jinan, Shandong; Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University, Guangzhou; Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University; Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University), Hefei; National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, and Peking Union Medical College, Beijing, China. This study was supported by the Science and Technology Planning Project of Guangdong Province, China (2016A020216013), Guangdong Natural Science Funds for Distinguished Young Scholars (Grant No. 2014A030306039), the Municipal Healthcare Joint-Innovation Major Project of Guangzhou and High-level Personnel of Special Support Program for Technology Innovative Talents and the Top Young of Guangdong Province (Grant No. 2015TQ01R516), the National Supercomputer Center in Guangzhou and the Agency of Science, Technology and Research (A*STAR) of Singapore, the HUJ-CREATE Programme of the National Research Foundation, Singapore (Project Number 370062002), the US National Institutes of Health (Grant Numbers R01CA144034 and UM1 CA182876), the Singapore National Medical Research Council (Grant Number 1270/2010), the 5010 Project of Sun Yat-sen University (Grant No. 2007023), Distinguished Young Scholar Candidates Programme for The Third Affiliated Hospital of Sun Yat-Sen University, and Pearl River Nova Program of Guangzhou (Grant No. 201610010005). X. Zheng, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Li, PhD, Third Affiliated Hospital of Sun Yat-sen University; X. Li, PhD, Third Affiliated Hospital of Sun Yat-sen University; Y. Zhang, PhD, Third Affiliated Hospital of Sun Yat-sen University; X. Wu, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Wei, BD, Third Affiliated Hospital of Sun Yat-sen University; S. Cao, BD, Third Affiliated Hospital of Sun Yat-sen University; M. Yang, PhD, Third Affiliated Hospital of Sun Yat-sen University; Z. Lin, PhD, Third Affiliated Hospital of Sun Yat-sen University; Z. Liao, PhD, Third Affiliated Hospital of Sun Yat-sen University; J. Qi, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Lv, PhD, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University; L. Wang, MD, Human Genetics, Genome Institute of Singapore, A*STAR; Y. Li, PhD, Human Genetics, Genome Institute of Singapore, A*STAR, and The Jackson Laboratory; A. Irwanto, PhD, Human Genetics, Genome Institute of Singapore, A*STAR; C. Cheng, PhD, SERI, Singapore National Eye Centre, Ophthalmology and Visual Sciences, Eye ACP, Duke-NUS Medical School, Department of Ophthalmology, Yong Loo Lin School of Medicine; X. Chai, PhD, SERI, Singapore National Eye Centre; C. Khor, PhD, Human Genetics, Genome Institute of Singapore, A*STAR; C. Heng, PhD, Department of Pediatrics, Yong Loo Lin School of Medicine, Khoo Teck Puat–National University Children’s Medical Institute, National University Health System; W. Koh, PhD, Saw Swee Hock School of Public Health, NUS, Health Systems and Services Research, Duke-NUS Medical School; J. Yuan, PhD, Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh; J. Bei, PhD, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center; F. Zhang, PhD, Shandong Provincial Institute of Dermatology and Venereology and Hospital for Skin Diseases, Shandong First Medical University and Shandong Academy of Medical Sciences; X. Zhang, PhD, Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University, Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University); Y. Zeng, PhD, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center; Y. Shen, PhD, National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College; J. Liu, PhD, Human Genetics, Genome Institute of Singapore, A*STAR, The Third Affiliated Hospital of Sun Yat-sen University; J. Gu, MD, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University. J. Liu and J. Gu jointly directed this work. X. Zheng and Q. Li contributed equally to this study. Address correspondence to Prof. J. Gu, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China; e-mail: gujieruo@163.com; or Prof. J. Liu, Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138672; e-mail: liuj3@gis.a-star.edu.sg. Accepted for publication August 23, 2019.
Xuejun Zhang
From the Department of Rheumatology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore; The Jackson Laboratory, Farmington, Connecticut, USA; the Singapore Eye Research Institute (SERI); the Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), the Health Systems and Services Research, Duke–National University of Singapore (NUS) Medical School; Departments of Ophthalmology and Pediatrics, Yong Loo Lin School of Medicine; the Khoo Teck Puat–National University Children’s Medical Institute; the Saw Swee Hock School of Public Health, National University of Singapore, Singapore; the division of Cancer Control and Population Sciences, University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou; Shandong Provincial Institute of Dermatology and Venereology and Hospital for Skin Diseases, Shandong First Medical University and Shandong Academy of Medical Sciences; National Clinical Key Project of Dermatology and Venereology, Jinan, Shandong; Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University, Guangzhou; Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University; Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University), Hefei; National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, and Peking Union Medical College, Beijing, China. This study was supported by the Science and Technology Planning Project of Guangdong Province, China (2016A020216013), Guangdong Natural Science Funds for Distinguished Young Scholars (Grant No. 2014A030306039), the Municipal Healthcare Joint-Innovation Major Project of Guangzhou and High-level Personnel of Special Support Program for Technology Innovative Talents and the Top Young of Guangdong Province (Grant No. 2015TQ01R516), the National Supercomputer Center in Guangzhou and the Agency of Science, Technology and Research (A*STAR) of Singapore, the HUJ-CREATE Programme of the National Research Foundation, Singapore (Project Number 370062002), the US National Institutes of Health (Grant Numbers R01CA144034 and UM1 CA182876), the Singapore National Medical Research Council (Grant Number 1270/2010), the 5010 Project of Sun Yat-sen University (Grant No. 2007023), Distinguished Young Scholar Candidates Programme for The Third Affiliated Hospital of Sun Yat-Sen University, and Pearl River Nova Program of Guangzhou (Grant No. 201610010005). X. Zheng, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Li, PhD, Third Affiliated Hospital of Sun Yat-sen University; X. Li, PhD, Third Affiliated Hospital of Sun Yat-sen University; Y. Zhang, PhD, Third Affiliated Hospital of Sun Yat-sen University; X. Wu, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Wei, BD, Third Affiliated Hospital of Sun Yat-sen University; S. Cao, BD, Third Affiliated Hospital of Sun Yat-sen University; M. Yang, PhD, Third Affiliated Hospital of Sun Yat-sen University; Z. Lin, PhD, Third Affiliated Hospital of Sun Yat-sen University; Z. Liao, PhD, Third Affiliated Hospital of Sun Yat-sen University; J. Qi, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Lv, PhD, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University; L. Wang, MD, Human Genetics, Genome Institute of Singapore, A*STAR; Y. Li, PhD, Human Genetics, Genome Institute of Singapore, A*STAR, and The Jackson Laboratory; A. Irwanto, PhD, Human Genetics, Genome Institute of Singapore, A*STAR; C. Cheng, PhD, SERI, Singapore National Eye Centre, Ophthalmology and Visual Sciences, Eye ACP, Duke-NUS Medical School, Department of Ophthalmology, Yong Loo Lin School of Medicine; X. Chai, PhD, SERI, Singapore National Eye Centre; C. Khor, PhD, Human Genetics, Genome Institute of Singapore, A*STAR; C. Heng, PhD, Department of Pediatrics, Yong Loo Lin School of Medicine, Khoo Teck Puat–National University Children’s Medical Institute, National University Health System; W. Koh, PhD, Saw Swee Hock School of Public Health, NUS, Health Systems and Services Research, Duke-NUS Medical School; J. Yuan, PhD, Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh; J. Bei, PhD, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center; F. Zhang, PhD, Shandong Provincial Institute of Dermatology and Venereology and Hospital for Skin Diseases, Shandong First Medical University and Shandong Academy of Medical Sciences; X. Zhang, PhD, Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University, Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University); Y. Zeng, PhD, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center; Y. Shen, PhD, National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College; J. Liu, PhD, Human Genetics, Genome Institute of Singapore, A*STAR, The Third Affiliated Hospital of Sun Yat-sen University; J. Gu, MD, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University. J. Liu and J. Gu jointly directed this work. X. Zheng and Q. Li contributed equally to this study. Address correspondence to Prof. J. Gu, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China; e-mail: gujieruo@163.com; or Prof. J. Liu, Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138672; e-mail: liuj3@gis.a-star.edu.sg. Accepted for publication August 23, 2019.
Yixin Zeng
From the Department of Rheumatology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore; The Jackson Laboratory, Farmington, Connecticut, USA; the Singapore Eye Research Institute (SERI); the Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), the Health Systems and Services Research, Duke–National University of Singapore (NUS) Medical School; Departments of Ophthalmology and Pediatrics, Yong Loo Lin School of Medicine; the Khoo Teck Puat–National University Children’s Medical Institute; the Saw Swee Hock School of Public Health, National University of Singapore, Singapore; the division of Cancer Control and Population Sciences, University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou; Shandong Provincial Institute of Dermatology and Venereology and Hospital for Skin Diseases, Shandong First Medical University and Shandong Academy of Medical Sciences; National Clinical Key Project of Dermatology and Venereology, Jinan, Shandong; Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University, Guangzhou; Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University; Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University), Hefei; National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, and Peking Union Medical College, Beijing, China. This study was supported by the Science and Technology Planning Project of Guangdong Province, China (2016A020216013), Guangdong Natural Science Funds for Distinguished Young Scholars (Grant No. 2014A030306039), the Municipal Healthcare Joint-Innovation Major Project of Guangzhou and High-level Personnel of Special Support Program for Technology Innovative Talents and the Top Young of Guangdong Province (Grant No. 2015TQ01R516), the National Supercomputer Center in Guangzhou and the Agency of Science, Technology and Research (A*STAR) of Singapore, the HUJ-CREATE Programme of the National Research Foundation, Singapore (Project Number 370062002), the US National Institutes of Health (Grant Numbers R01CA144034 and UM1 CA182876), the Singapore National Medical Research Council (Grant Number 1270/2010), the 5010 Project of Sun Yat-sen University (Grant No. 2007023), Distinguished Young Scholar Candidates Programme for The Third Affiliated Hospital of Sun Yat-Sen University, and Pearl River Nova Program of Guangzhou (Grant No. 201610010005). X. Zheng, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Li, PhD, Third Affiliated Hospital of Sun Yat-sen University; X. Li, PhD, Third Affiliated Hospital of Sun Yat-sen University; Y. Zhang, PhD, Third Affiliated Hospital of Sun Yat-sen University; X. Wu, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Wei, BD, Third Affiliated Hospital of Sun Yat-sen University; S. Cao, BD, Third Affiliated Hospital of Sun Yat-sen University; M. Yang, PhD, Third Affiliated Hospital of Sun Yat-sen University; Z. Lin, PhD, Third Affiliated Hospital of Sun Yat-sen University; Z. Liao, PhD, Third Affiliated Hospital of Sun Yat-sen University; J. Qi, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Lv, PhD, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University; L. Wang, MD, Human Genetics, Genome Institute of Singapore, A*STAR; Y. Li, PhD, Human Genetics, Genome Institute of Singapore, A*STAR, and The Jackson Laboratory; A. Irwanto, PhD, Human Genetics, Genome Institute of Singapore, A*STAR; C. Cheng, PhD, SERI, Singapore National Eye Centre, Ophthalmology and Visual Sciences, Eye ACP, Duke-NUS Medical School, Department of Ophthalmology, Yong Loo Lin School of Medicine; X. Chai, PhD, SERI, Singapore National Eye Centre; C. Khor, PhD, Human Genetics, Genome Institute of Singapore, A*STAR; C. Heng, PhD, Department of Pediatrics, Yong Loo Lin School of Medicine, Khoo Teck Puat–National University Children’s Medical Institute, National University Health System; W. Koh, PhD, Saw Swee Hock School of Public Health, NUS, Health Systems and Services Research, Duke-NUS Medical School; J. Yuan, PhD, Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh; J. Bei, PhD, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center; F. Zhang, PhD, Shandong Provincial Institute of Dermatology and Venereology and Hospital for Skin Diseases, Shandong First Medical University and Shandong Academy of Medical Sciences; X. Zhang, PhD, Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University, Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University); Y. Zeng, PhD, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center; Y. Shen, PhD, National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College; J. Liu, PhD, Human Genetics, Genome Institute of Singapore, A*STAR, The Third Affiliated Hospital of Sun Yat-sen University; J. Gu, MD, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University. J. Liu and J. Gu jointly directed this work. X. Zheng and Q. Li contributed equally to this study. Address correspondence to Prof. J. Gu, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China; e-mail: gujieruo@163.com; or Prof. J. Liu, Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138672; e-mail: liuj3@gis.a-star.edu.sg. Accepted for publication August 23, 2019.
Yan Shen
From the Department of Rheumatology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore; The Jackson Laboratory, Farmington, Connecticut, USA; the Singapore Eye Research Institute (SERI); the Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), the Health Systems and Services Research, Duke–National University of Singapore (NUS) Medical School; Departments of Ophthalmology and Pediatrics, Yong Loo Lin School of Medicine; the Khoo Teck Puat–National University Children’s Medical Institute; the Saw Swee Hock School of Public Health, National University of Singapore, Singapore; the division of Cancer Control and Population Sciences, University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou; Shandong Provincial Institute of Dermatology and Venereology and Hospital for Skin Diseases, Shandong First Medical University and Shandong Academy of Medical Sciences; National Clinical Key Project of Dermatology and Venereology, Jinan, Shandong; Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University, Guangzhou; Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University; Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University), Hefei; National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, and Peking Union Medical College, Beijing, China. This study was supported by the Science and Technology Planning Project of Guangdong Province, China (2016A020216013), Guangdong Natural Science Funds for Distinguished Young Scholars (Grant No. 2014A030306039), the Municipal Healthcare Joint-Innovation Major Project of Guangzhou and High-level Personnel of Special Support Program for Technology Innovative Talents and the Top Young of Guangdong Province (Grant No. 2015TQ01R516), the National Supercomputer Center in Guangzhou and the Agency of Science, Technology and Research (A*STAR) of Singapore, the HUJ-CREATE Programme of the National Research Foundation, Singapore (Project Number 370062002), the US National Institutes of Health (Grant Numbers R01CA144034 and UM1 CA182876), the Singapore National Medical Research Council (Grant Number 1270/2010), the 5010 Project of Sun Yat-sen University (Grant No. 2007023), Distinguished Young Scholar Candidates Programme for The Third Affiliated Hospital of Sun Yat-Sen University, and Pearl River Nova Program of Guangzhou (Grant No. 201610010005). X. Zheng, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Li, PhD, Third Affiliated Hospital of Sun Yat-sen University; X. Li, PhD, Third Affiliated Hospital of Sun Yat-sen University; Y. Zhang, PhD, Third Affiliated Hospital of Sun Yat-sen University; X. Wu, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Wei, BD, Third Affiliated Hospital of Sun Yat-sen University; S. Cao, BD, Third Affiliated Hospital of Sun Yat-sen University; M. Yang, PhD, Third Affiliated Hospital of Sun Yat-sen University; Z. Lin, PhD, Third Affiliated Hospital of Sun Yat-sen University; Z. Liao, PhD, Third Affiliated Hospital of Sun Yat-sen University; J. Qi, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Lv, PhD, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University; L. Wang, MD, Human Genetics, Genome Institute of Singapore, A*STAR; Y. Li, PhD, Human Genetics, Genome Institute of Singapore, A*STAR, and The Jackson Laboratory; A. Irwanto, PhD, Human Genetics, Genome Institute of Singapore, A*STAR; C. Cheng, PhD, SERI, Singapore National Eye Centre, Ophthalmology and Visual Sciences, Eye ACP, Duke-NUS Medical School, Department of Ophthalmology, Yong Loo Lin School of Medicine; X. Chai, PhD, SERI, Singapore National Eye Centre; C. Khor, PhD, Human Genetics, Genome Institute of Singapore, A*STAR; C. Heng, PhD, Department of Pediatrics, Yong Loo Lin School of Medicine, Khoo Teck Puat–National University Children’s Medical Institute, National University Health System; W. Koh, PhD, Saw Swee Hock School of Public Health, NUS, Health Systems and Services Research, Duke-NUS Medical School; J. Yuan, PhD, Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh; J. Bei, PhD, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center; F. Zhang, PhD, Shandong Provincial Institute of Dermatology and Venereology and Hospital for Skin Diseases, Shandong First Medical University and Shandong Academy of Medical Sciences; X. Zhang, PhD, Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University, Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University); Y. Zeng, PhD, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center; Y. Shen, PhD, National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College; J. Liu, PhD, Human Genetics, Genome Institute of Singapore, A*STAR, The Third Affiliated Hospital of Sun Yat-sen University; J. Gu, MD, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University. J. Liu and J. Gu jointly directed this work. X. Zheng and Q. Li contributed equally to this study. Address correspondence to Prof. J. Gu, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China; e-mail: gujieruo@163.com; or Prof. J. Liu, Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138672; e-mail: liuj3@gis.a-star.edu.sg. Accepted for publication August 23, 2019.
Jianjun Liu
From the Department of Rheumatology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore; The Jackson Laboratory, Farmington, Connecticut, USA; the Singapore Eye Research Institute (SERI); the Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), the Health Systems and Services Research, Duke–National University of Singapore (NUS) Medical School; Departments of Ophthalmology and Pediatrics, Yong Loo Lin School of Medicine; the Khoo Teck Puat–National University Children’s Medical Institute; the Saw Swee Hock School of Public Health, National University of Singapore, Singapore; the division of Cancer Control and Population Sciences, University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou; Shandong Provincial Institute of Dermatology and Venereology and Hospital for Skin Diseases, Shandong First Medical University and Shandong Academy of Medical Sciences; National Clinical Key Project of Dermatology and Venereology, Jinan, Shandong; Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University, Guangzhou; Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University; Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University), Hefei; National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, and Peking Union Medical College, Beijing, China. This study was supported by the Science and Technology Planning Project of Guangdong Province, China (2016A020216013), Guangdong Natural Science Funds for Distinguished Young Scholars (Grant No. 2014A030306039), the Municipal Healthcare Joint-Innovation Major Project of Guangzhou and High-level Personnel of Special Support Program for Technology Innovative Talents and the Top Young of Guangdong Province (Grant No. 2015TQ01R516), the National Supercomputer Center in Guangzhou and the Agency of Science, Technology and Research (A*STAR) of Singapore, the HUJ-CREATE Programme of the National Research Foundation, Singapore (Project Number 370062002), the US National Institutes of Health (Grant Numbers R01CA144034 and UM1 CA182876), the Singapore National Medical Research Council (Grant Number 1270/2010), the 5010 Project of Sun Yat-sen University (Grant No. 2007023), Distinguished Young Scholar Candidates Programme for The Third Affiliated Hospital of Sun Yat-Sen University, and Pearl River Nova Program of Guangzhou (Grant No. 201610010005). X. Zheng, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Li, PhD, Third Affiliated Hospital of Sun Yat-sen University; X. Li, PhD, Third Affiliated Hospital of Sun Yat-sen University; Y. Zhang, PhD, Third Affiliated Hospital of Sun Yat-sen University; X. Wu, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Wei, BD, Third Affiliated Hospital of Sun Yat-sen University; S. Cao, BD, Third Affiliated Hospital of Sun Yat-sen University; M. Yang, PhD, Third Affiliated Hospital of Sun Yat-sen University; Z. Lin, PhD, Third Affiliated Hospital of Sun Yat-sen University; Z. Liao, PhD, Third Affiliated Hospital of Sun Yat-sen University; J. Qi, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Lv, PhD, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University; L. Wang, MD, Human Genetics, Genome Institute of Singapore, A*STAR; Y. Li, PhD, Human Genetics, Genome Institute of Singapore, A*STAR, and The Jackson Laboratory; A. Irwanto, PhD, Human Genetics, Genome Institute of Singapore, A*STAR; C. Cheng, PhD, SERI, Singapore National Eye Centre, Ophthalmology and Visual Sciences, Eye ACP, Duke-NUS Medical School, Department of Ophthalmology, Yong Loo Lin School of Medicine; X. Chai, PhD, SERI, Singapore National Eye Centre; C. Khor, PhD, Human Genetics, Genome Institute of Singapore, A*STAR; C. Heng, PhD, Department of Pediatrics, Yong Loo Lin School of Medicine, Khoo Teck Puat–National University Children’s Medical Institute, National University Health System; W. Koh, PhD, Saw Swee Hock School of Public Health, NUS, Health Systems and Services Research, Duke-NUS Medical School; J. Yuan, PhD, Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh; J. Bei, PhD, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center; F. Zhang, PhD, Shandong Provincial Institute of Dermatology and Venereology and Hospital for Skin Diseases, Shandong First Medical University and Shandong Academy of Medical Sciences; X. Zhang, PhD, Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University, Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University); Y. Zeng, PhD, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center; Y. Shen, PhD, National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College; J. Liu, PhD, Human Genetics, Genome Institute of Singapore, A*STAR, The Third Affiliated Hospital of Sun Yat-sen University; J. Gu, MD, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University. J. Liu and J. Gu jointly directed this work. X. Zheng and Q. Li contributed equally to this study. Address correspondence to Prof. J. Gu, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China; e-mail: gujieruo@163.com; or Prof. J. Liu, Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138672; e-mail: liuj3@gis.a-star.edu.sg. Accepted for publication August 23, 2019.
Jieruo Gu
From the Department of Rheumatology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore; The Jackson Laboratory, Farmington, Connecticut, USA; the Singapore Eye Research Institute (SERI); the Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), the Health Systems and Services Research, Duke–National University of Singapore (NUS) Medical School; Departments of Ophthalmology and Pediatrics, Yong Loo Lin School of Medicine; the Khoo Teck Puat–National University Children’s Medical Institute; the Saw Swee Hock School of Public Health, National University of Singapore, Singapore; the division of Cancer Control and Population Sciences, University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou; Shandong Provincial Institute of Dermatology and Venereology and Hospital for Skin Diseases, Shandong First Medical University and Shandong Academy of Medical Sciences; National Clinical Key Project of Dermatology and Venereology, Jinan, Shandong; Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University, Guangzhou; Institute of Dermatology and Department of Dermatology, No. 1 Hospital, Anhui Medical University; Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University), Hefei; National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, and Peking Union Medical College, Beijing, China. This study was supported by the Science and Technology Planning Project of Guangdong Province, China (2016A020216013), Guangdong Natural Science Funds for Distinguished Young Scholars (Grant No. 2014A030306039), the Municipal Healthcare Joint-Innovation Major Project of Guangzhou and High-level Personnel of Special Support Program for Technology Innovative Talents and the Top Young of Guangdong Province (Grant No. 2015TQ01R516), the National Supercomputer Center in Guangzhou and the Agency of Science, Technology and Research (A*STAR) of Singapore, the HUJ-CREATE Programme of the National Research Foundation, Singapore (Project Number 370062002), the US National Institutes of Health (Grant Numbers R01CA144034 and UM1 CA182876), the Singapore National Medical Research Council (Grant Number 1270/2010), the 5010 Project of Sun Yat-sen University (Grant No. 2007023), Distinguished Young Scholar Candidates Programme for The Third Affiliated Hospital of Sun Yat-Sen University, and Pearl River Nova Program of Guangzhou (Grant No. 201610010005). X. Zheng, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Li, PhD, Third Affiliated Hospital of Sun Yat-sen University; X. Li, PhD, Third Affiliated Hospital of Sun Yat-sen University; Y. Zhang, PhD, Third Affiliated Hospital of Sun Yat-sen University; X. Wu, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Wei, BD, Third Affiliated Hospital of Sun Yat-sen University; S. Cao, BD, Third Affiliated Hospital of Sun Yat-sen University; M. Yang, PhD, Third Affiliated Hospital of Sun Yat-sen University; Z. Lin, PhD, Third Affiliated Hospital of Sun Yat-sen University; Z. Liao, PhD, Third Affiliated Hospital of Sun Yat-sen University; J. Qi, PhD, Third Affiliated Hospital of Sun Yat-sen University; Q. Lv, PhD, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University; L. Wang, MD, Human Genetics, Genome Institute of Singapore, A*STAR; Y. Li, PhD, Human Genetics, Genome Institute of Singapore, A*STAR, and The Jackson Laboratory; A. Irwanto, PhD, Human Genetics, Genome Institute of Singapore, A*STAR; C. Cheng, PhD, SERI, Singapore National Eye Centre, Ophthalmology and Visual Sciences, Eye ACP, Duke-NUS Medical School, Department of Ophthalmology, Yong Loo Lin School of Medicine; X. Chai, PhD, SERI, Singapore National Eye Centre; C. Khor, PhD, Human Genetics, Genome Institute of Singapore, A*STAR; C. Heng, PhD, Department of Pediatrics, Yong Loo Lin School of Medicine, Khoo Teck Puat–National University Children’s Medical Institute, National University Health System; W. Koh, PhD, Saw Swee Hock School of Public Health, NUS, Health Systems and Services Research, Duke-NUS Medical School; J. Yuan, PhD, Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh; J. Bei, PhD, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center; F. Zhang, PhD, Shandong Provincial Institute of Dermatology and Venereology and Hospital for Skin Diseases, Shandong First Medical University and Shandong Academy of Medical Sciences; X. Zhang, PhD, Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University, Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University); Y. Zeng, PhD, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center; Y. Shen, PhD, National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College; J. Liu, PhD, Human Genetics, Genome Institute of Singapore, A*STAR, The Third Affiliated Hospital of Sun Yat-sen University; J. Gu, MD, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University. J. Liu and J. Gu jointly directed this work. X. Zheng and Q. Li contributed equally to this study. Address correspondence to Prof. J. Gu, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China; e-mail: gujieruo@163.com; or Prof. J. Liu, Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138672; e-mail: liuj3@gis.a-star.edu.sg. Accepted for publication August 23, 2019.
Data supplements
Data Supplement
In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Analysis of 47 Non-MHC Ankylosing Spondylitis Susceptibility Loci Regarding Associated Variants across Whites and Han Chinese
Xuqi Zheng, Qiuxia Li, Xiaomin Li, Yanli Zhang, Xinyu Wu, Qiujing Wei, Shuangyan Cao, Mingcan Yang, Zhiming Lin, Zetao Liao, Jun Qi, Qing Lv, Ling Wang, Yi Li, Astrid Irwanto, Ching-Yu Cheng, Xiaoran Chai, Chiea Chuen Khor, Chew-Kiat Heng, Woon-Puay Koh, Jian-Min Yuan, Jinxin Bei, Furen Zhang, Xuejun Zhang, Yixin Zeng, Yan Shen, Jianjun Liu, Jieruo Gu
The Journal of Rheumatology Sep 2019, jrheum.190184; DOI: 10.3899/jrheum.190184
Analysis of 47 Non-MHC Ankylosing Spondylitis Susceptibility Loci Regarding Associated Variants across Whites and Han Chinese
Xuqi Zheng, Qiuxia Li, Xiaomin Li, Yanli Zhang, Xinyu Wu, Qiujing Wei, Shuangyan Cao, Mingcan Yang, Zhiming Lin, Zetao Liao, Jun Qi, Qing Lv, Ling Wang, Yi Li, Astrid Irwanto, Ching-Yu Cheng, Xiaoran Chai, Chiea Chuen Khor, Chew-Kiat Heng, Woon-Puay Koh, Jian-Min Yuan, Jinxin Bei, Furen Zhang, Xuejun Zhang, Yixin Zeng, Yan Shen, Jianjun Liu, Jieruo Gu
The Journal of Rheumatology Sep 2019, jrheum.190184; DOI: 10.3899/jrheum.190184