Research ArticleArticle
Rituximab-associated Vasculitis Flare: Incidence, Predictors, and Outcome
Anne Claire Desbois, Lucie Biard, Damien Sène, Isabelle Brocheriou, Philippe Rouvier, Bertrand Lioger, Lucile Musset, Sophie Candon, Thierry Zenone, Matthieu Resche-Rigon, Jean-Charles Piette, Neila Benameur, Patrice Cacoub and David Saadoun
The Journal of Rheumatology August 2019, jrheum.190076; DOI: https://doi.org/10.3899/jrheum.190076
Anne Claire Desbois
From the Départements Hospitalo-Universitaires (DHU) Inflammation, Immunopathologie, Biothérapie, Université Pierre et Marie Curie; AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology, Department of Pathology, Laboratory of Immunology, and Pharmacy Department; Département de Biostatistiques, Hôpital Saint-Louis; AP-HP, Groupe Hospitalier Lariboisière, Department of Internal Medicine, Paris; Hôpital Bretonneau, Centre Hospitalier de Tours, Department of Internal Medicine, Tours; Hôpital Necker, Laboratory of Immunology, Paris; Centre Hospitalier de Valence, Department of Internal Medicine, Valence, France. A.C. Desbois, MD, PhD, DHU Inflammation, Immunopathologie, Biothérapie, Université Pierre et Marie Curie, and AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology; L. Biard, MD, PhD, Département de Biostatistiques, Hôpital Saint-Louis; D. Sène, MD, PhD, AP-HP, Groupe Hospitalier Lariboisière, Department of Internal Medicine; I. Brocheriou, MD, PhD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Pathology; P. Rouvier, MD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Pathology; B. Lioger, MD, PhD, Hôpital Bretonneau, Centre Hospitalier de Tours, Department of Internal Medicine; L. Musset, MD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Laboratory of Immunology; S. Candon, MD, PhD, Hôpital Necker, Laboratory of Immunology; T. Zenone, MD, Centre Hospitalier de Valence, Department of Internal Medicine; M. Resche-Rigon, MD, PhD, Département de Biostatistiques, Hôpital Saint-Louis; J.C. Piette, MD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology; N. Benameur, MD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Pharmacy; P. Cacoub, MD, PhD, DHU Inflammation, Immunopathologie, Biothérapie, Université Pierre et Marie Curie, and AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology; D. Saadoun, MD, PhD, DHU Inflammation, Immunopathologie, Biothérapie, Université Pierre et Marie Curie, and AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology. Dr. Cacoub and Dr. Saadoun are co-senior authors. Address correspondence Dr. D. Saadoun, AP-HP, Hôpital Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology, 83 Boulevard de l’hôpital, F-75013, Paris, France. E-mail: david.saadoun@aphp.fr. Accepted for publication July 12, 2019.
Lucie Biard
From the Départements Hospitalo-Universitaires (DHU) Inflammation, Immunopathologie, Biothérapie, Université Pierre et Marie Curie; AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology, Department of Pathology, Laboratory of Immunology, and Pharmacy Department; Département de Biostatistiques, Hôpital Saint-Louis; AP-HP, Groupe Hospitalier Lariboisière, Department of Internal Medicine, Paris; Hôpital Bretonneau, Centre Hospitalier de Tours, Department of Internal Medicine, Tours; Hôpital Necker, Laboratory of Immunology, Paris; Centre Hospitalier de Valence, Department of Internal Medicine, Valence, France. A.C. Desbois, MD, PhD, DHU Inflammation, Immunopathologie, Biothérapie, Université Pierre et Marie Curie, and AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology; L. Biard, MD, PhD, Département de Biostatistiques, Hôpital Saint-Louis; D. Sène, MD, PhD, AP-HP, Groupe Hospitalier Lariboisière, Department of Internal Medicine; I. Brocheriou, MD, PhD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Pathology; P. Rouvier, MD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Pathology; B. Lioger, MD, PhD, Hôpital Bretonneau, Centre Hospitalier de Tours, Department of Internal Medicine; L. Musset, MD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Laboratory of Immunology; S. Candon, MD, PhD, Hôpital Necker, Laboratory of Immunology; T. Zenone, MD, Centre Hospitalier de Valence, Department of Internal Medicine; M. Resche-Rigon, MD, PhD, Département de Biostatistiques, Hôpital Saint-Louis; J.C. Piette, MD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology; N. Benameur, MD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Pharmacy; P. Cacoub, MD, PhD, DHU Inflammation, Immunopathologie, Biothérapie, Université Pierre et Marie Curie, and AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology; D. Saadoun, MD, PhD, DHU Inflammation, Immunopathologie, Biothérapie, Université Pierre et Marie Curie, and AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology. Dr. Cacoub and Dr. Saadoun are co-senior authors. Address correspondence Dr. D. Saadoun, AP-HP, Hôpital Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology, 83 Boulevard de l’hôpital, F-75013, Paris, France. E-mail: david.saadoun@aphp.fr. Accepted for publication July 12, 2019.
Damien Sène
From the Départements Hospitalo-Universitaires (DHU) Inflammation, Immunopathologie, Biothérapie, Université Pierre et Marie Curie; AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology, Department of Pathology, Laboratory of Immunology, and Pharmacy Department; Département de Biostatistiques, Hôpital Saint-Louis; AP-HP, Groupe Hospitalier Lariboisière, Department of Internal Medicine, Paris; Hôpital Bretonneau, Centre Hospitalier de Tours, Department of Internal Medicine, Tours; Hôpital Necker, Laboratory of Immunology, Paris; Centre Hospitalier de Valence, Department of Internal Medicine, Valence, France. A.C. Desbois, MD, PhD, DHU Inflammation, Immunopathologie, Biothérapie, Université Pierre et Marie Curie, and AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology; L. Biard, MD, PhD, Département de Biostatistiques, Hôpital Saint-Louis; D. Sène, MD, PhD, AP-HP, Groupe Hospitalier Lariboisière, Department of Internal Medicine; I. Brocheriou, MD, PhD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Pathology; P. Rouvier, MD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Pathology; B. Lioger, MD, PhD, Hôpital Bretonneau, Centre Hospitalier de Tours, Department of Internal Medicine; L. Musset, MD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Laboratory of Immunology; S. Candon, MD, PhD, Hôpital Necker, Laboratory of Immunology; T. Zenone, MD, Centre Hospitalier de Valence, Department of Internal Medicine; M. Resche-Rigon, MD, PhD, Département de Biostatistiques, Hôpital Saint-Louis; J.C. Piette, MD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology; N. Benameur, MD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Pharmacy; P. Cacoub, MD, PhD, DHU Inflammation, Immunopathologie, Biothérapie, Université Pierre et Marie Curie, and AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology; D. Saadoun, MD, PhD, DHU Inflammation, Immunopathologie, Biothérapie, Université Pierre et Marie Curie, and AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology. Dr. Cacoub and Dr. Saadoun are co-senior authors. Address correspondence Dr. D. Saadoun, AP-HP, Hôpital Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology, 83 Boulevard de l’hôpital, F-75013, Paris, France. E-mail: david.saadoun@aphp.fr. Accepted for publication July 12, 2019.
Isabelle Brocheriou
From the Départements Hospitalo-Universitaires (DHU) Inflammation, Immunopathologie, Biothérapie, Université Pierre et Marie Curie; AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology, Department of Pathology, Laboratory of Immunology, and Pharmacy Department; Département de Biostatistiques, Hôpital Saint-Louis; AP-HP, Groupe Hospitalier Lariboisière, Department of Internal Medicine, Paris; Hôpital Bretonneau, Centre Hospitalier de Tours, Department of Internal Medicine, Tours; Hôpital Necker, Laboratory of Immunology, Paris; Centre Hospitalier de Valence, Department of Internal Medicine, Valence, France. A.C. Desbois, MD, PhD, DHU Inflammation, Immunopathologie, Biothérapie, Université Pierre et Marie Curie, and AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology; L. Biard, MD, PhD, Département de Biostatistiques, Hôpital Saint-Louis; D. Sène, MD, PhD, AP-HP, Groupe Hospitalier Lariboisière, Department of Internal Medicine; I. Brocheriou, MD, PhD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Pathology; P. Rouvier, MD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Pathology; B. Lioger, MD, PhD, Hôpital Bretonneau, Centre Hospitalier de Tours, Department of Internal Medicine; L. Musset, MD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Laboratory of Immunology; S. Candon, MD, PhD, Hôpital Necker, Laboratory of Immunology; T. Zenone, MD, Centre Hospitalier de Valence, Department of Internal Medicine; M. Resche-Rigon, MD, PhD, Département de Biostatistiques, Hôpital Saint-Louis; J.C. Piette, MD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology; N. Benameur, MD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Pharmacy; P. Cacoub, MD, PhD, DHU Inflammation, Immunopathologie, Biothérapie, Université Pierre et Marie Curie, and AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology; D. Saadoun, MD, PhD, DHU Inflammation, Immunopathologie, Biothérapie, Université Pierre et Marie Curie, and AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology. Dr. Cacoub and Dr. Saadoun are co-senior authors. Address correspondence Dr. D. Saadoun, AP-HP, Hôpital Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology, 83 Boulevard de l’hôpital, F-75013, Paris, France. E-mail: david.saadoun@aphp.fr. Accepted for publication July 12, 2019.
Philippe Rouvier
From the Départements Hospitalo-Universitaires (DHU) Inflammation, Immunopathologie, Biothérapie, Université Pierre et Marie Curie; AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology, Department of Pathology, Laboratory of Immunology, and Pharmacy Department; Département de Biostatistiques, Hôpital Saint-Louis; AP-HP, Groupe Hospitalier Lariboisière, Department of Internal Medicine, Paris; Hôpital Bretonneau, Centre Hospitalier de Tours, Department of Internal Medicine, Tours; Hôpital Necker, Laboratory of Immunology, Paris; Centre Hospitalier de Valence, Department of Internal Medicine, Valence, France. A.C. Desbois, MD, PhD, DHU Inflammation, Immunopathologie, Biothérapie, Université Pierre et Marie Curie, and AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology; L. Biard, MD, PhD, Département de Biostatistiques, Hôpital Saint-Louis; D. Sène, MD, PhD, AP-HP, Groupe Hospitalier Lariboisière, Department of Internal Medicine; I. Brocheriou, MD, PhD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Pathology; P. Rouvier, MD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Pathology; B. Lioger, MD, PhD, Hôpital Bretonneau, Centre Hospitalier de Tours, Department of Internal Medicine; L. Musset, MD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Laboratory of Immunology; S. Candon, MD, PhD, Hôpital Necker, Laboratory of Immunology; T. Zenone, MD, Centre Hospitalier de Valence, Department of Internal Medicine; M. Resche-Rigon, MD, PhD, Département de Biostatistiques, Hôpital Saint-Louis; J.C. Piette, MD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology; N. Benameur, MD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Pharmacy; P. Cacoub, MD, PhD, DHU Inflammation, Immunopathologie, Biothérapie, Université Pierre et Marie Curie, and AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology; D. Saadoun, MD, PhD, DHU Inflammation, Immunopathologie, Biothérapie, Université Pierre et Marie Curie, and AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology. Dr. Cacoub and Dr. Saadoun are co-senior authors. Address correspondence Dr. D. Saadoun, AP-HP, Hôpital Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology, 83 Boulevard de l’hôpital, F-75013, Paris, France. E-mail: david.saadoun@aphp.fr. Accepted for publication July 12, 2019.
Bertrand Lioger
From the Départements Hospitalo-Universitaires (DHU) Inflammation, Immunopathologie, Biothérapie, Université Pierre et Marie Curie; AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology, Department of Pathology, Laboratory of Immunology, and Pharmacy Department; Département de Biostatistiques, Hôpital Saint-Louis; AP-HP, Groupe Hospitalier Lariboisière, Department of Internal Medicine, Paris; Hôpital Bretonneau, Centre Hospitalier de Tours, Department of Internal Medicine, Tours; Hôpital Necker, Laboratory of Immunology, Paris; Centre Hospitalier de Valence, Department of Internal Medicine, Valence, France. A.C. Desbois, MD, PhD, DHU Inflammation, Immunopathologie, Biothérapie, Université Pierre et Marie Curie, and AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology; L. Biard, MD, PhD, Département de Biostatistiques, Hôpital Saint-Louis; D. Sène, MD, PhD, AP-HP, Groupe Hospitalier Lariboisière, Department of Internal Medicine; I. Brocheriou, MD, PhD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Pathology; P. Rouvier, MD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Pathology; B. Lioger, MD, PhD, Hôpital Bretonneau, Centre Hospitalier de Tours, Department of Internal Medicine; L. Musset, MD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Laboratory of Immunology; S. Candon, MD, PhD, Hôpital Necker, Laboratory of Immunology; T. Zenone, MD, Centre Hospitalier de Valence, Department of Internal Medicine; M. Resche-Rigon, MD, PhD, Département de Biostatistiques, Hôpital Saint-Louis; J.C. Piette, MD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology; N. Benameur, MD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Pharmacy; P. Cacoub, MD, PhD, DHU Inflammation, Immunopathologie, Biothérapie, Université Pierre et Marie Curie, and AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology; D. Saadoun, MD, PhD, DHU Inflammation, Immunopathologie, Biothérapie, Université Pierre et Marie Curie, and AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology. Dr. Cacoub and Dr. Saadoun are co-senior authors. Address correspondence Dr. D. Saadoun, AP-HP, Hôpital Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology, 83 Boulevard de l’hôpital, F-75013, Paris, France. E-mail: david.saadoun@aphp.fr. Accepted for publication July 12, 2019.
Lucile Musset
From the Départements Hospitalo-Universitaires (DHU) Inflammation, Immunopathologie, Biothérapie, Université Pierre et Marie Curie; AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology, Department of Pathology, Laboratory of Immunology, and Pharmacy Department; Département de Biostatistiques, Hôpital Saint-Louis; AP-HP, Groupe Hospitalier Lariboisière, Department of Internal Medicine, Paris; Hôpital Bretonneau, Centre Hospitalier de Tours, Department of Internal Medicine, Tours; Hôpital Necker, Laboratory of Immunology, Paris; Centre Hospitalier de Valence, Department of Internal Medicine, Valence, France. A.C. Desbois, MD, PhD, DHU Inflammation, Immunopathologie, Biothérapie, Université Pierre et Marie Curie, and AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology; L. Biard, MD, PhD, Département de Biostatistiques, Hôpital Saint-Louis; D. Sène, MD, PhD, AP-HP, Groupe Hospitalier Lariboisière, Department of Internal Medicine; I. Brocheriou, MD, PhD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Pathology; P. Rouvier, MD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Pathology; B. Lioger, MD, PhD, Hôpital Bretonneau, Centre Hospitalier de Tours, Department of Internal Medicine; L. Musset, MD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Laboratory of Immunology; S. Candon, MD, PhD, Hôpital Necker, Laboratory of Immunology; T. Zenone, MD, Centre Hospitalier de Valence, Department of Internal Medicine; M. Resche-Rigon, MD, PhD, Département de Biostatistiques, Hôpital Saint-Louis; J.C. Piette, MD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology; N. Benameur, MD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Pharmacy; P. Cacoub, MD, PhD, DHU Inflammation, Immunopathologie, Biothérapie, Université Pierre et Marie Curie, and AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology; D. Saadoun, MD, PhD, DHU Inflammation, Immunopathologie, Biothérapie, Université Pierre et Marie Curie, and AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology. Dr. Cacoub and Dr. Saadoun are co-senior authors. Address correspondence Dr. D. Saadoun, AP-HP, Hôpital Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology, 83 Boulevard de l’hôpital, F-75013, Paris, France. E-mail: david.saadoun@aphp.fr. Accepted for publication July 12, 2019.
Sophie Candon
From the Départements Hospitalo-Universitaires (DHU) Inflammation, Immunopathologie, Biothérapie, Université Pierre et Marie Curie; AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology, Department of Pathology, Laboratory of Immunology, and Pharmacy Department; Département de Biostatistiques, Hôpital Saint-Louis; AP-HP, Groupe Hospitalier Lariboisière, Department of Internal Medicine, Paris; Hôpital Bretonneau, Centre Hospitalier de Tours, Department of Internal Medicine, Tours; Hôpital Necker, Laboratory of Immunology, Paris; Centre Hospitalier de Valence, Department of Internal Medicine, Valence, France. A.C. Desbois, MD, PhD, DHU Inflammation, Immunopathologie, Biothérapie, Université Pierre et Marie Curie, and AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology; L. Biard, MD, PhD, Département de Biostatistiques, Hôpital Saint-Louis; D. Sène, MD, PhD, AP-HP, Groupe Hospitalier Lariboisière, Department of Internal Medicine; I. Brocheriou, MD, PhD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Pathology; P. Rouvier, MD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Pathology; B. Lioger, MD, PhD, Hôpital Bretonneau, Centre Hospitalier de Tours, Department of Internal Medicine; L. Musset, MD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Laboratory of Immunology; S. Candon, MD, PhD, Hôpital Necker, Laboratory of Immunology; T. Zenone, MD, Centre Hospitalier de Valence, Department of Internal Medicine; M. Resche-Rigon, MD, PhD, Département de Biostatistiques, Hôpital Saint-Louis; J.C. Piette, MD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology; N. Benameur, MD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Pharmacy; P. Cacoub, MD, PhD, DHU Inflammation, Immunopathologie, Biothérapie, Université Pierre et Marie Curie, and AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology; D. Saadoun, MD, PhD, DHU Inflammation, Immunopathologie, Biothérapie, Université Pierre et Marie Curie, and AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology. Dr. Cacoub and Dr. Saadoun are co-senior authors. Address correspondence Dr. D. Saadoun, AP-HP, Hôpital Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology, 83 Boulevard de l’hôpital, F-75013, Paris, France. E-mail: david.saadoun@aphp.fr. Accepted for publication July 12, 2019.
Thierry Zenone
From the Départements Hospitalo-Universitaires (DHU) Inflammation, Immunopathologie, Biothérapie, Université Pierre et Marie Curie; AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology, Department of Pathology, Laboratory of Immunology, and Pharmacy Department; Département de Biostatistiques, Hôpital Saint-Louis; AP-HP, Groupe Hospitalier Lariboisière, Department of Internal Medicine, Paris; Hôpital Bretonneau, Centre Hospitalier de Tours, Department of Internal Medicine, Tours; Hôpital Necker, Laboratory of Immunology, Paris; Centre Hospitalier de Valence, Department of Internal Medicine, Valence, France. A.C. Desbois, MD, PhD, DHU Inflammation, Immunopathologie, Biothérapie, Université Pierre et Marie Curie, and AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology; L. Biard, MD, PhD, Département de Biostatistiques, Hôpital Saint-Louis; D. Sène, MD, PhD, AP-HP, Groupe Hospitalier Lariboisière, Department of Internal Medicine; I. Brocheriou, MD, PhD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Pathology; P. Rouvier, MD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Pathology; B. Lioger, MD, PhD, Hôpital Bretonneau, Centre Hospitalier de Tours, Department of Internal Medicine; L. Musset, MD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Laboratory of Immunology; S. Candon, MD, PhD, Hôpital Necker, Laboratory of Immunology; T. Zenone, MD, Centre Hospitalier de Valence, Department of Internal Medicine; M. Resche-Rigon, MD, PhD, Département de Biostatistiques, Hôpital Saint-Louis; J.C. Piette, MD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology; N. Benameur, MD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Pharmacy; P. Cacoub, MD, PhD, DHU Inflammation, Immunopathologie, Biothérapie, Université Pierre et Marie Curie, and AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology; D. Saadoun, MD, PhD, DHU Inflammation, Immunopathologie, Biothérapie, Université Pierre et Marie Curie, and AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology. Dr. Cacoub and Dr. Saadoun are co-senior authors. Address correspondence Dr. D. Saadoun, AP-HP, Hôpital Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology, 83 Boulevard de l’hôpital, F-75013, Paris, France. E-mail: david.saadoun@aphp.fr. Accepted for publication July 12, 2019.
Matthieu Resche-Rigon
From the Départements Hospitalo-Universitaires (DHU) Inflammation, Immunopathologie, Biothérapie, Université Pierre et Marie Curie; AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology, Department of Pathology, Laboratory of Immunology, and Pharmacy Department; Département de Biostatistiques, Hôpital Saint-Louis; AP-HP, Groupe Hospitalier Lariboisière, Department of Internal Medicine, Paris; Hôpital Bretonneau, Centre Hospitalier de Tours, Department of Internal Medicine, Tours; Hôpital Necker, Laboratory of Immunology, Paris; Centre Hospitalier de Valence, Department of Internal Medicine, Valence, France. A.C. Desbois, MD, PhD, DHU Inflammation, Immunopathologie, Biothérapie, Université Pierre et Marie Curie, and AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology; L. Biard, MD, PhD, Département de Biostatistiques, Hôpital Saint-Louis; D. Sène, MD, PhD, AP-HP, Groupe Hospitalier Lariboisière, Department of Internal Medicine; I. Brocheriou, MD, PhD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Pathology; P. Rouvier, MD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Pathology; B. Lioger, MD, PhD, Hôpital Bretonneau, Centre Hospitalier de Tours, Department of Internal Medicine; L. Musset, MD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Laboratory of Immunology; S. Candon, MD, PhD, Hôpital Necker, Laboratory of Immunology; T. Zenone, MD, Centre Hospitalier de Valence, Department of Internal Medicine; M. Resche-Rigon, MD, PhD, Département de Biostatistiques, Hôpital Saint-Louis; J.C. Piette, MD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology; N. Benameur, MD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Pharmacy; P. Cacoub, MD, PhD, DHU Inflammation, Immunopathologie, Biothérapie, Université Pierre et Marie Curie, and AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology; D. Saadoun, MD, PhD, DHU Inflammation, Immunopathologie, Biothérapie, Université Pierre et Marie Curie, and AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology. Dr. Cacoub and Dr. Saadoun are co-senior authors. Address correspondence Dr. D. Saadoun, AP-HP, Hôpital Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology, 83 Boulevard de l’hôpital, F-75013, Paris, France. E-mail: david.saadoun@aphp.fr. Accepted for publication July 12, 2019.
Jean-Charles Piette
From the Départements Hospitalo-Universitaires (DHU) Inflammation, Immunopathologie, Biothérapie, Université Pierre et Marie Curie; AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology, Department of Pathology, Laboratory of Immunology, and Pharmacy Department; Département de Biostatistiques, Hôpital Saint-Louis; AP-HP, Groupe Hospitalier Lariboisière, Department of Internal Medicine, Paris; Hôpital Bretonneau, Centre Hospitalier de Tours, Department of Internal Medicine, Tours; Hôpital Necker, Laboratory of Immunology, Paris; Centre Hospitalier de Valence, Department of Internal Medicine, Valence, France. A.C. Desbois, MD, PhD, DHU Inflammation, Immunopathologie, Biothérapie, Université Pierre et Marie Curie, and AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology; L. Biard, MD, PhD, Département de Biostatistiques, Hôpital Saint-Louis; D. Sène, MD, PhD, AP-HP, Groupe Hospitalier Lariboisière, Department of Internal Medicine; I. Brocheriou, MD, PhD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Pathology; P. Rouvier, MD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Pathology; B. Lioger, MD, PhD, Hôpital Bretonneau, Centre Hospitalier de Tours, Department of Internal Medicine; L. Musset, MD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Laboratory of Immunology; S. Candon, MD, PhD, Hôpital Necker, Laboratory of Immunology; T. Zenone, MD, Centre Hospitalier de Valence, Department of Internal Medicine; M. Resche-Rigon, MD, PhD, Département de Biostatistiques, Hôpital Saint-Louis; J.C. Piette, MD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology; N. Benameur, MD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Pharmacy; P. Cacoub, MD, PhD, DHU Inflammation, Immunopathologie, Biothérapie, Université Pierre et Marie Curie, and AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology; D. Saadoun, MD, PhD, DHU Inflammation, Immunopathologie, Biothérapie, Université Pierre et Marie Curie, and AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology. Dr. Cacoub and Dr. Saadoun are co-senior authors. Address correspondence Dr. D. Saadoun, AP-HP, Hôpital Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology, 83 Boulevard de l’hôpital, F-75013, Paris, France. E-mail: david.saadoun@aphp.fr. Accepted for publication July 12, 2019.
Neila Benameur
From the Départements Hospitalo-Universitaires (DHU) Inflammation, Immunopathologie, Biothérapie, Université Pierre et Marie Curie; AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology, Department of Pathology, Laboratory of Immunology, and Pharmacy Department; Département de Biostatistiques, Hôpital Saint-Louis; AP-HP, Groupe Hospitalier Lariboisière, Department of Internal Medicine, Paris; Hôpital Bretonneau, Centre Hospitalier de Tours, Department of Internal Medicine, Tours; Hôpital Necker, Laboratory of Immunology, Paris; Centre Hospitalier de Valence, Department of Internal Medicine, Valence, France. A.C. Desbois, MD, PhD, DHU Inflammation, Immunopathologie, Biothérapie, Université Pierre et Marie Curie, and AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology; L. Biard, MD, PhD, Département de Biostatistiques, Hôpital Saint-Louis; D. Sène, MD, PhD, AP-HP, Groupe Hospitalier Lariboisière, Department of Internal Medicine; I. Brocheriou, MD, PhD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Pathology; P. Rouvier, MD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Pathology; B. Lioger, MD, PhD, Hôpital Bretonneau, Centre Hospitalier de Tours, Department of Internal Medicine; L. Musset, MD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Laboratory of Immunology; S. Candon, MD, PhD, Hôpital Necker, Laboratory of Immunology; T. Zenone, MD, Centre Hospitalier de Valence, Department of Internal Medicine; M. Resche-Rigon, MD, PhD, Département de Biostatistiques, Hôpital Saint-Louis; J.C. Piette, MD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology; N. Benameur, MD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Pharmacy; P. Cacoub, MD, PhD, DHU Inflammation, Immunopathologie, Biothérapie, Université Pierre et Marie Curie, and AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology; D. Saadoun, MD, PhD, DHU Inflammation, Immunopathologie, Biothérapie, Université Pierre et Marie Curie, and AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology. Dr. Cacoub and Dr. Saadoun are co-senior authors. Address correspondence Dr. D. Saadoun, AP-HP, Hôpital Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology, 83 Boulevard de l’hôpital, F-75013, Paris, France. E-mail: david.saadoun@aphp.fr. Accepted for publication July 12, 2019.
Patrice Cacoub
From the Départements Hospitalo-Universitaires (DHU) Inflammation, Immunopathologie, Biothérapie, Université Pierre et Marie Curie; AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology, Department of Pathology, Laboratory of Immunology, and Pharmacy Department; Département de Biostatistiques, Hôpital Saint-Louis; AP-HP, Groupe Hospitalier Lariboisière, Department of Internal Medicine, Paris; Hôpital Bretonneau, Centre Hospitalier de Tours, Department of Internal Medicine, Tours; Hôpital Necker, Laboratory of Immunology, Paris; Centre Hospitalier de Valence, Department of Internal Medicine, Valence, France. A.C. Desbois, MD, PhD, DHU Inflammation, Immunopathologie, Biothérapie, Université Pierre et Marie Curie, and AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology; L. Biard, MD, PhD, Département de Biostatistiques, Hôpital Saint-Louis; D. Sène, MD, PhD, AP-HP, Groupe Hospitalier Lariboisière, Department of Internal Medicine; I. Brocheriou, MD, PhD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Pathology; P. Rouvier, MD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Pathology; B. Lioger, MD, PhD, Hôpital Bretonneau, Centre Hospitalier de Tours, Department of Internal Medicine; L. Musset, MD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Laboratory of Immunology; S. Candon, MD, PhD, Hôpital Necker, Laboratory of Immunology; T. Zenone, MD, Centre Hospitalier de Valence, Department of Internal Medicine; M. Resche-Rigon, MD, PhD, Département de Biostatistiques, Hôpital Saint-Louis; J.C. Piette, MD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology; N. Benameur, MD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Pharmacy; P. Cacoub, MD, PhD, DHU Inflammation, Immunopathologie, Biothérapie, Université Pierre et Marie Curie, and AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology; D. Saadoun, MD, PhD, DHU Inflammation, Immunopathologie, Biothérapie, Université Pierre et Marie Curie, and AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology. Dr. Cacoub and Dr. Saadoun are co-senior authors. Address correspondence Dr. D. Saadoun, AP-HP, Hôpital Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology, 83 Boulevard de l’hôpital, F-75013, Paris, France. E-mail: david.saadoun@aphp.fr. Accepted for publication July 12, 2019.
David Saadoun
From the Départements Hospitalo-Universitaires (DHU) Inflammation, Immunopathologie, Biothérapie, Université Pierre et Marie Curie; AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology, Department of Pathology, Laboratory of Immunology, and Pharmacy Department; Département de Biostatistiques, Hôpital Saint-Louis; AP-HP, Groupe Hospitalier Lariboisière, Department of Internal Medicine, Paris; Hôpital Bretonneau, Centre Hospitalier de Tours, Department of Internal Medicine, Tours; Hôpital Necker, Laboratory of Immunology, Paris; Centre Hospitalier de Valence, Department of Internal Medicine, Valence, France. A.C. Desbois, MD, PhD, DHU Inflammation, Immunopathologie, Biothérapie, Université Pierre et Marie Curie, and AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology; L. Biard, MD, PhD, Département de Biostatistiques, Hôpital Saint-Louis; D. Sène, MD, PhD, AP-HP, Groupe Hospitalier Lariboisière, Department of Internal Medicine; I. Brocheriou, MD, PhD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Pathology; P. Rouvier, MD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Pathology; B. Lioger, MD, PhD, Hôpital Bretonneau, Centre Hospitalier de Tours, Department of Internal Medicine; L. Musset, MD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Laboratory of Immunology; S. Candon, MD, PhD, Hôpital Necker, Laboratory of Immunology; T. Zenone, MD, Centre Hospitalier de Valence, Department of Internal Medicine; M. Resche-Rigon, MD, PhD, Département de Biostatistiques, Hôpital Saint-Louis; J.C. Piette, MD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology; N. Benameur, MD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Pharmacy; P. Cacoub, MD, PhD, DHU Inflammation, Immunopathologie, Biothérapie, Université Pierre et Marie Curie, and AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology; D. Saadoun, MD, PhD, DHU Inflammation, Immunopathologie, Biothérapie, Université Pierre et Marie Curie, and AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology. Dr. Cacoub and Dr. Saadoun are co-senior authors. Address correspondence Dr. D. Saadoun, AP-HP, Hôpital Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology, 83 Boulevard de l’hôpital, F-75013, Paris, France. E-mail: david.saadoun@aphp.fr. Accepted for publication July 12, 2019.
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- Published online March 15, 2020.
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© 2020 The Journal of Rheumatology
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- Anne Claire Desbois,
- Lucie Biard,
- Damien Sène,
- Isabelle Brocheriou,
- Philippe Rouvier,
- Bertrand Lioger,
- Lucile Musset,
- Sophie Candon,
- Thierry Zenone,
- Matthieu Resche-Rigon,
- Jean-Charles Piette,
- Neila Benameur,
- Patrice Cacoub and
- David Saadoun
- From the Départements Hospitalo-Universitaires (DHU) Inflammation, Immunopathologie, Biothérapie, Université Pierre et Marie Curie; AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology, Department of Pathology, Laboratory of Immunology, and Pharmacy Department; Département de Biostatistiques, Hôpital Saint-Louis; AP-HP, Groupe Hospitalier Lariboisière, Department of Internal Medicine, Paris; Hôpital Bretonneau, Centre Hospitalier de Tours, Department of Internal Medicine, Tours; Hôpital Necker, Laboratory of Immunology, Paris; Centre Hospitalier de Valence, Department of Internal Medicine, Valence, France.
A.C. Desbois, MD, PhD, DHU Inflammation, Immunopathologie, Biothérapie, Université Pierre et Marie Curie, and AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology; L. Biard, MD, PhD, Département de Biostatistiques, Hôpital Saint-Louis; D. Sène, MD, PhD, AP-HP, Groupe Hospitalier Lariboisière, Department of Internal Medicine; I. Brocheriou, MD, PhD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Pathology; P. Rouvier, MD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Pathology; B. Lioger, MD, PhD, Hôpital Bretonneau, Centre Hospitalier de Tours, Department of Internal Medicine; L. Musset, MD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Laboratory of Immunology; S. Candon, MD, PhD, Hôpital Necker, Laboratory of Immunology; T. Zenone, MD, Centre Hospitalier de Valence, Department of Internal Medicine; M. Resche-Rigon, MD, PhD, Département de Biostatistiques, Hôpital Saint-Louis; J.C. Piette, MD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology; N. Benameur, MD, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Pharmacy; P. Cacoub, MD, PhD, DHU Inflammation, Immunopathologie, Biothérapie, Université Pierre et Marie Curie, and AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology; D. Saadoun, MD, PhD, DHU Inflammation, Immunopathologie, Biothérapie, Université Pierre et Marie Curie, and AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology. Dr. Cacoub and Dr. Saadoun are co-senior authors.
Address correspondence Dr. D. Saadoun, AP-HP, Hôpital Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology, 83 Boulevard de l’hôpital, F-75013, Paris, France. E-mail: david.saadoun@aphp.fr.
Accepted for publication July 12, 2019.
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In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Rituximab-associated Vasculitis Flare: Incidence, Predictors, and Outcome
Anne Claire Desbois, Lucie Biard, Damien Sène, Isabelle Brocheriou, Philippe Rouvier, Bertrand Lioger, Lucile Musset, Sophie Candon, Thierry Zenone, Matthieu Resche-Rigon, Jean-Charles Piette, Neila Benameur, Patrice Cacoub, David Saadoun
The Journal of Rheumatology Aug 2019, jrheum.190076; DOI: 10.3899/jrheum.190076
Rituximab-associated Vasculitis Flare: Incidence, Predictors, and Outcome
Anne Claire Desbois, Lucie Biard, Damien Sène, Isabelle Brocheriou, Philippe Rouvier, Bertrand Lioger, Lucile Musset, Sophie Candon, Thierry Zenone, Matthieu Resche-Rigon, Jean-Charles Piette, Neila Benameur, Patrice Cacoub, David Saadoun
The Journal of Rheumatology Aug 2019, jrheum.190076; DOI: 10.3899/jrheum.190076