LetterLetter
Is There a Role for LAMP-2 Autoantibodies in Patients with Antineutrophil Cytoplasmic Antibody–associated Vasculitis?
Sergey Moiseev, Anastasiia Zykova, Nikolay Bulanov, Evgeny Gitel, Pavel Novikov, Mayra Bulanova, Andreas Kronbichler and David Jayne
The Journal of Rheumatology February 2020, jrheum.191082; DOI: https://doi.org/10.3899/jrheum.191082
Sergey Moiseev
From the Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University, and Lomonosov Moscow State University, Lomonosov Moscow State University, Moscow, Russia; Vladimir Regional Clinical Hospital, Vladimir, Russia; Department of Internal Medicine IV (Nephrology and Hypertension), Medical University Innsbruck, Innsbruck, Austria; Department of Medicine, University of Cambridge, Cambridge, UK. The study was supported by a grant from Sechenov University. Dr. Kronbichler has received an unrestricted grant from the Austrian Society of Rheumatology. Address correspondence to Dr. S. Moiseev, Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University, Rossolimo, 11/5, Moscow, 119435, Russia. E-mail: avt420034@yahoo.com
Anastasiia Zykova
From the Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University, and Lomonosov Moscow State University, Lomonosov Moscow State University, Moscow, Russia; Vladimir Regional Clinical Hospital, Vladimir, Russia; Department of Internal Medicine IV (Nephrology and Hypertension), Medical University Innsbruck, Innsbruck, Austria; Department of Medicine, University of Cambridge, Cambridge, UK. The study was supported by a grant from Sechenov University. Dr. Kronbichler has received an unrestricted grant from the Austrian Society of Rheumatology. Address correspondence to Dr. S. Moiseev, Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University, Rossolimo, 11/5, Moscow, 119435, Russia. E-mail: avt420034@yahoo.com
Nikolay Bulanov
From the Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University, and Lomonosov Moscow State University, Lomonosov Moscow State University, Moscow, Russia; Vladimir Regional Clinical Hospital, Vladimir, Russia; Department of Internal Medicine IV (Nephrology and Hypertension), Medical University Innsbruck, Innsbruck, Austria; Department of Medicine, University of Cambridge, Cambridge, UK. The study was supported by a grant from Sechenov University. Dr. Kronbichler has received an unrestricted grant from the Austrian Society of Rheumatology. Address correspondence to Dr. S. Moiseev, Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University, Rossolimo, 11/5, Moscow, 119435, Russia. E-mail: avt420034@yahoo.com
Evgeny Gitel
From the Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University, and Lomonosov Moscow State University, Lomonosov Moscow State University, Moscow, Russia; Vladimir Regional Clinical Hospital, Vladimir, Russia; Department of Internal Medicine IV (Nephrology and Hypertension), Medical University Innsbruck, Innsbruck, Austria; Department of Medicine, University of Cambridge, Cambridge, UK. The study was supported by a grant from Sechenov University. Dr. Kronbichler has received an unrestricted grant from the Austrian Society of Rheumatology. Address correspondence to Dr. S. Moiseev, Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University, Rossolimo, 11/5, Moscow, 119435, Russia. E-mail: avt420034@yahoo.com
Pavel Novikov
From the Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University, and Lomonosov Moscow State University, Lomonosov Moscow State University, Moscow, Russia; Vladimir Regional Clinical Hospital, Vladimir, Russia; Department of Internal Medicine IV (Nephrology and Hypertension), Medical University Innsbruck, Innsbruck, Austria; Department of Medicine, University of Cambridge, Cambridge, UK. The study was supported by a grant from Sechenov University. Dr. Kronbichler has received an unrestricted grant from the Austrian Society of Rheumatology. Address correspondence to Dr. S. Moiseev, Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University, Rossolimo, 11/5, Moscow, 119435, Russia. E-mail: avt420034@yahoo.com
Mayra Bulanova
From the Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University, and Lomonosov Moscow State University, Lomonosov Moscow State University, Moscow, Russia; Vladimir Regional Clinical Hospital, Vladimir, Russia; Department of Internal Medicine IV (Nephrology and Hypertension), Medical University Innsbruck, Innsbruck, Austria; Department of Medicine, University of Cambridge, Cambridge, UK. The study was supported by a grant from Sechenov University. Dr. Kronbichler has received an unrestricted grant from the Austrian Society of Rheumatology. Address correspondence to Dr. S. Moiseev, Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University, Rossolimo, 11/5, Moscow, 119435, Russia. E-mail: avt420034@yahoo.com
Andreas Kronbichler
From the Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University, and Lomonosov Moscow State University, Lomonosov Moscow State University, Moscow, Russia; Vladimir Regional Clinical Hospital, Vladimir, Russia; Department of Internal Medicine IV (Nephrology and Hypertension), Medical University Innsbruck, Innsbruck, Austria; Department of Medicine, University of Cambridge, Cambridge, UK. The study was supported by a grant from Sechenov University. Dr. Kronbichler has received an unrestricted grant from the Austrian Society of Rheumatology. Address correspondence to Dr. S. Moiseev, Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University, Rossolimo, 11/5, Moscow, 119435, Russia. E-mail: avt420034@yahoo.com
David Jayne
From the Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University, and Lomonosov Moscow State University, Lomonosov Moscow State University, Moscow, Russia; Vladimir Regional Clinical Hospital, Vladimir, Russia; Department of Internal Medicine IV (Nephrology and Hypertension), Medical University Innsbruck, Innsbruck, Austria; Department of Medicine, University of Cambridge, Cambridge, UK. The study was supported by a grant from Sechenov University. Dr. Kronbichler has received an unrestricted grant from the Austrian Society of Rheumatology. Address correspondence to Dr. S. Moiseev, Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University, Rossolimo, 11/5, Moscow, 119435, Russia. E-mail: avt420034@yahoo.com
Abstract
Antineutrophil cytoplasmic antibody (ANCA)–associated vasculitides (AAV) form a group of necrotizing small-vessel vasculitides characterized by the presence of ANCA against either proteinase 3 (PR3) or myeloperoxidase (MPO). ANCA have a key role in the pathogenesis of AAV, inducing excessive activation of neutrophils, which results in injury to small vessels1. ANCA can target other neutrophil-derived molecules, among them lysosome-associated membrane glycoprotein 2 (LAMP-2).
In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Is There a Role for LAMP-2 Autoantibodies in Patients with Antineutrophil Cytoplasmic Antibody–associated Vasculitis?
Sergey Moiseev, Anastasiia Zykova, Nikolay Bulanov, Evgeny Gitel, Pavel Novikov, Mayra Bulanova, Andreas Kronbichler, David Jayne
The Journal of Rheumatology Feb 2020, jrheum.191082; DOI: 10.3899/jrheum.191082
Is There a Role for LAMP-2 Autoantibodies in Patients with Antineutrophil Cytoplasmic Antibody–associated Vasculitis?
Sergey Moiseev, Anastasiia Zykova, Nikolay Bulanov, Evgeny Gitel, Pavel Novikov, Mayra Bulanova, Andreas Kronbichler, David Jayne
The Journal of Rheumatology Feb 2020, jrheum.191082; DOI: 10.3899/jrheum.191082