Research ArticleAccepted Article
A single APOL1 nephropathy variant increases risk of advanced lupus nephritis in Brazilians
Gisele Vajgel, Suelen Cristina Lima, Diego Jeronimo S. Santana, Camila B. L. Oliveira, Denise Maria N. Costa, Pamela J. Hicks, Maria Alina G. M. Cavalcante, Carl D. Langefeld, Lucila Maria Valente, Sergio Crovella, Gianna Mastroianni Kirsztajn, Barry I. Freedman and Paula Sandrin-Garcia
The Journal of Rheumatology November 2019, jrheum.190684; DOI: https://doi.org/10.3899/jrheum.190684
Gisele Vajgel
From the Division of Nephrology, Hospital das Clinicas, Federal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil; Molecular Biology Laboratory, Keizo Asami Immunopathology Laboratory (LIKA), Federal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil; Division of Nephrology, Instituto de Medicina Integral Prof Fernando Figueira (IMIP), Recife, Pernambuco, Brazil; Division of Public Health Sciences, Department of Biostatistical Sciences; Wake Forest School of Medicine, Winston-Salem, North Carolina, USA; Division of Nephrology, Department of Medicine, Federal University of São Paulo (UNIFESP), São Paulo, Brazil; Center for Diabetes Research; Wake Forest School of Medicine, Winston- Salem, North Carolina, USA; Department of Internal Medicine, Section on Nephrology; Wake Forest School of Medicine, Winston-Salem, North Carolina, USA. Wake Forest University Health Sciences and BIF have rights to an issued US patent related to APOL1 genetic testing (www.apol1genetest.com). Dr. Freedman is a consultant for AstraZeneca Pharmaceuticals and Renalytix AI. Address correspondence to Dr. Gisele Vajgel (@gvajgel) Division of Nephrology, Hospital das Clinicas, Federal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil Av. Prof Moraes Rego, 1235. Cidade Universitaria Recife PE – Brazil ZIP: 50670-901. E-mail: giselevajgel@hotmail.com
Suelen Cristina Lima
From the Division of Nephrology, Hospital das Clinicas, Federal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil; Molecular Biology Laboratory, Keizo Asami Immunopathology Laboratory (LIKA), Federal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil; Division of Nephrology, Instituto de Medicina Integral Prof Fernando Figueira (IMIP), Recife, Pernambuco, Brazil; Division of Public Health Sciences, Department of Biostatistical Sciences; Wake Forest School of Medicine, Winston-Salem, North Carolina, USA; Division of Nephrology, Department of Medicine, Federal University of São Paulo (UNIFESP), São Paulo, Brazil; Center for Diabetes Research; Wake Forest School of Medicine, Winston- Salem, North Carolina, USA; Department of Internal Medicine, Section on Nephrology; Wake Forest School of Medicine, Winston-Salem, North Carolina, USA. Wake Forest University Health Sciences and BIF have rights to an issued US patent related to APOL1 genetic testing (www.apol1genetest.com). Dr. Freedman is a consultant for AstraZeneca Pharmaceuticals and Renalytix AI. Address correspondence to Dr. Gisele Vajgel (@gvajgel) Division of Nephrology, Hospital das Clinicas, Federal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil Av. Prof Moraes Rego, 1235. Cidade Universitaria Recife PE – Brazil ZIP: 50670-901. E-mail: giselevajgel@hotmail.com
Diego Jeronimo S. Santana
From the Division of Nephrology, Hospital das Clinicas, Federal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil; Molecular Biology Laboratory, Keizo Asami Immunopathology Laboratory (LIKA), Federal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil; Division of Nephrology, Instituto de Medicina Integral Prof Fernando Figueira (IMIP), Recife, Pernambuco, Brazil; Division of Public Health Sciences, Department of Biostatistical Sciences; Wake Forest School of Medicine, Winston-Salem, North Carolina, USA; Division of Nephrology, Department of Medicine, Federal University of São Paulo (UNIFESP), São Paulo, Brazil; Center for Diabetes Research; Wake Forest School of Medicine, Winston- Salem, North Carolina, USA; Department of Internal Medicine, Section on Nephrology; Wake Forest School of Medicine, Winston-Salem, North Carolina, USA. Wake Forest University Health Sciences and BIF have rights to an issued US patent related to APOL1 genetic testing (www.apol1genetest.com). Dr. Freedman is a consultant for AstraZeneca Pharmaceuticals and Renalytix AI. Address correspondence to Dr. Gisele Vajgel (@gvajgel) Division of Nephrology, Hospital das Clinicas, Federal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil Av. Prof Moraes Rego, 1235. Cidade Universitaria Recife PE – Brazil ZIP: 50670-901. E-mail: giselevajgel@hotmail.com
Camila B. L. Oliveira
From the Division of Nephrology, Hospital das Clinicas, Federal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil; Molecular Biology Laboratory, Keizo Asami Immunopathology Laboratory (LIKA), Federal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil; Division of Nephrology, Instituto de Medicina Integral Prof Fernando Figueira (IMIP), Recife, Pernambuco, Brazil; Division of Public Health Sciences, Department of Biostatistical Sciences; Wake Forest School of Medicine, Winston-Salem, North Carolina, USA; Division of Nephrology, Department of Medicine, Federal University of São Paulo (UNIFESP), São Paulo, Brazil; Center for Diabetes Research; Wake Forest School of Medicine, Winston- Salem, North Carolina, USA; Department of Internal Medicine, Section on Nephrology; Wake Forest School of Medicine, Winston-Salem, North Carolina, USA. Wake Forest University Health Sciences and BIF have rights to an issued US patent related to APOL1 genetic testing (www.apol1genetest.com). Dr. Freedman is a consultant for AstraZeneca Pharmaceuticals and Renalytix AI. Address correspondence to Dr. Gisele Vajgel (@gvajgel) Division of Nephrology, Hospital das Clinicas, Federal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil Av. Prof Moraes Rego, 1235. Cidade Universitaria Recife PE – Brazil ZIP: 50670-901. E-mail: giselevajgel@hotmail.com
Denise Maria N. Costa
From the Division of Nephrology, Hospital das Clinicas, Federal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil; Molecular Biology Laboratory, Keizo Asami Immunopathology Laboratory (LIKA), Federal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil; Division of Nephrology, Instituto de Medicina Integral Prof Fernando Figueira (IMIP), Recife, Pernambuco, Brazil; Division of Public Health Sciences, Department of Biostatistical Sciences; Wake Forest School of Medicine, Winston-Salem, North Carolina, USA; Division of Nephrology, Department of Medicine, Federal University of São Paulo (UNIFESP), São Paulo, Brazil; Center for Diabetes Research; Wake Forest School of Medicine, Winston- Salem, North Carolina, USA; Department of Internal Medicine, Section on Nephrology; Wake Forest School of Medicine, Winston-Salem, North Carolina, USA. Wake Forest University Health Sciences and BIF have rights to an issued US patent related to APOL1 genetic testing (www.apol1genetest.com). Dr. Freedman is a consultant for AstraZeneca Pharmaceuticals and Renalytix AI. Address correspondence to Dr. Gisele Vajgel (@gvajgel) Division of Nephrology, Hospital das Clinicas, Federal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil Av. Prof Moraes Rego, 1235. Cidade Universitaria Recife PE – Brazil ZIP: 50670-901. E-mail: giselevajgel@hotmail.com
Pamela J. Hicks
From the Division of Nephrology, Hospital das Clinicas, Federal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil; Molecular Biology Laboratory, Keizo Asami Immunopathology Laboratory (LIKA), Federal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil; Division of Nephrology, Instituto de Medicina Integral Prof Fernando Figueira (IMIP), Recife, Pernambuco, Brazil; Division of Public Health Sciences, Department of Biostatistical Sciences; Wake Forest School of Medicine, Winston-Salem, North Carolina, USA; Division of Nephrology, Department of Medicine, Federal University of São Paulo (UNIFESP), São Paulo, Brazil; Center for Diabetes Research; Wake Forest School of Medicine, Winston- Salem, North Carolina, USA; Department of Internal Medicine, Section on Nephrology; Wake Forest School of Medicine, Winston-Salem, North Carolina, USA. Wake Forest University Health Sciences and BIF have rights to an issued US patent related to APOL1 genetic testing (www.apol1genetest.com). Dr. Freedman is a consultant for AstraZeneca Pharmaceuticals and Renalytix AI. Address correspondence to Dr. Gisele Vajgel (@gvajgel) Division of Nephrology, Hospital das Clinicas, Federal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil Av. Prof Moraes Rego, 1235. Cidade Universitaria Recife PE – Brazil ZIP: 50670-901. E-mail: giselevajgel@hotmail.com
Maria Alina G. M. Cavalcante
From the Division of Nephrology, Hospital das Clinicas, Federal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil; Molecular Biology Laboratory, Keizo Asami Immunopathology Laboratory (LIKA), Federal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil; Division of Nephrology, Instituto de Medicina Integral Prof Fernando Figueira (IMIP), Recife, Pernambuco, Brazil; Division of Public Health Sciences, Department of Biostatistical Sciences; Wake Forest School of Medicine, Winston-Salem, North Carolina, USA; Division of Nephrology, Department of Medicine, Federal University of São Paulo (UNIFESP), São Paulo, Brazil; Center for Diabetes Research; Wake Forest School of Medicine, Winston- Salem, North Carolina, USA; Department of Internal Medicine, Section on Nephrology; Wake Forest School of Medicine, Winston-Salem, North Carolina, USA. Wake Forest University Health Sciences and BIF have rights to an issued US patent related to APOL1 genetic testing (www.apol1genetest.com). Dr. Freedman is a consultant for AstraZeneca Pharmaceuticals and Renalytix AI. Address correspondence to Dr. Gisele Vajgel (@gvajgel) Division of Nephrology, Hospital das Clinicas, Federal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil Av. Prof Moraes Rego, 1235. Cidade Universitaria Recife PE – Brazil ZIP: 50670-901. E-mail: giselevajgel@hotmail.com
Carl D. Langefeld
From the Division of Nephrology, Hospital das Clinicas, Federal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil; Molecular Biology Laboratory, Keizo Asami Immunopathology Laboratory (LIKA), Federal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil; Division of Nephrology, Instituto de Medicina Integral Prof Fernando Figueira (IMIP), Recife, Pernambuco, Brazil; Division of Public Health Sciences, Department of Biostatistical Sciences; Wake Forest School of Medicine, Winston-Salem, North Carolina, USA; Division of Nephrology, Department of Medicine, Federal University of São Paulo (UNIFESP), São Paulo, Brazil; Center for Diabetes Research; Wake Forest School of Medicine, Winston- Salem, North Carolina, USA; Department of Internal Medicine, Section on Nephrology; Wake Forest School of Medicine, Winston-Salem, North Carolina, USA. Wake Forest University Health Sciences and BIF have rights to an issued US patent related to APOL1 genetic testing (www.apol1genetest.com). Dr. Freedman is a consultant for AstraZeneca Pharmaceuticals and Renalytix AI. Address correspondence to Dr. Gisele Vajgel (@gvajgel) Division of Nephrology, Hospital das Clinicas, Federal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil Av. Prof Moraes Rego, 1235. Cidade Universitaria Recife PE – Brazil ZIP: 50670-901. E-mail: giselevajgel@hotmail.com
Lucila Maria Valente
From the Division of Nephrology, Hospital das Clinicas, Federal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil; Molecular Biology Laboratory, Keizo Asami Immunopathology Laboratory (LIKA), Federal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil; Division of Nephrology, Instituto de Medicina Integral Prof Fernando Figueira (IMIP), Recife, Pernambuco, Brazil; Division of Public Health Sciences, Department of Biostatistical Sciences; Wake Forest School of Medicine, Winston-Salem, North Carolina, USA; Division of Nephrology, Department of Medicine, Federal University of São Paulo (UNIFESP), São Paulo, Brazil; Center for Diabetes Research; Wake Forest School of Medicine, Winston- Salem, North Carolina, USA; Department of Internal Medicine, Section on Nephrology; Wake Forest School of Medicine, Winston-Salem, North Carolina, USA. Wake Forest University Health Sciences and BIF have rights to an issued US patent related to APOL1 genetic testing (www.apol1genetest.com). Dr. Freedman is a consultant for AstraZeneca Pharmaceuticals and Renalytix AI. Address correspondence to Dr. Gisele Vajgel (@gvajgel) Division of Nephrology, Hospital das Clinicas, Federal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil Av. Prof Moraes Rego, 1235. Cidade Universitaria Recife PE – Brazil ZIP: 50670-901. E-mail: giselevajgel@hotmail.com
Sergio Crovella
From the Division of Nephrology, Hospital das Clinicas, Federal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil; Molecular Biology Laboratory, Keizo Asami Immunopathology Laboratory (LIKA), Federal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil; Division of Nephrology, Instituto de Medicina Integral Prof Fernando Figueira (IMIP), Recife, Pernambuco, Brazil; Division of Public Health Sciences, Department of Biostatistical Sciences; Wake Forest School of Medicine, Winston-Salem, North Carolina, USA; Division of Nephrology, Department of Medicine, Federal University of São Paulo (UNIFESP), São Paulo, Brazil; Center for Diabetes Research; Wake Forest School of Medicine, Winston- Salem, North Carolina, USA; Department of Internal Medicine, Section on Nephrology; Wake Forest School of Medicine, Winston-Salem, North Carolina, USA. Wake Forest University Health Sciences and BIF have rights to an issued US patent related to APOL1 genetic testing (www.apol1genetest.com). Dr. Freedman is a consultant for AstraZeneca Pharmaceuticals and Renalytix AI. Address correspondence to Dr. Gisele Vajgel (@gvajgel) Division of Nephrology, Hospital das Clinicas, Federal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil Av. Prof Moraes Rego, 1235. Cidade Universitaria Recife PE – Brazil ZIP: 50670-901. E-mail: giselevajgel@hotmail.com
Gianna Mastroianni Kirsztajn
From the Division of Nephrology, Hospital das Clinicas, Federal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil; Molecular Biology Laboratory, Keizo Asami Immunopathology Laboratory (LIKA), Federal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil; Division of Nephrology, Instituto de Medicina Integral Prof Fernando Figueira (IMIP), Recife, Pernambuco, Brazil; Division of Public Health Sciences, Department of Biostatistical Sciences; Wake Forest School of Medicine, Winston-Salem, North Carolina, USA; Division of Nephrology, Department of Medicine, Federal University of São Paulo (UNIFESP), São Paulo, Brazil; Center for Diabetes Research; Wake Forest School of Medicine, Winston- Salem, North Carolina, USA; Department of Internal Medicine, Section on Nephrology; Wake Forest School of Medicine, Winston-Salem, North Carolina, USA. Wake Forest University Health Sciences and BIF have rights to an issued US patent related to APOL1 genetic testing (www.apol1genetest.com). Dr. Freedman is a consultant for AstraZeneca Pharmaceuticals and Renalytix AI. Address correspondence to Dr. Gisele Vajgel (@gvajgel) Division of Nephrology, Hospital das Clinicas, Federal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil Av. Prof Moraes Rego, 1235. Cidade Universitaria Recife PE – Brazil ZIP: 50670-901. E-mail: giselevajgel@hotmail.com
Barry I. Freedman
From the Division of Nephrology, Hospital das Clinicas, Federal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil; Molecular Biology Laboratory, Keizo Asami Immunopathology Laboratory (LIKA), Federal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil; Division of Nephrology, Instituto de Medicina Integral Prof Fernando Figueira (IMIP), Recife, Pernambuco, Brazil; Division of Public Health Sciences, Department of Biostatistical Sciences; Wake Forest School of Medicine, Winston-Salem, North Carolina, USA; Division of Nephrology, Department of Medicine, Federal University of São Paulo (UNIFESP), São Paulo, Brazil; Center for Diabetes Research; Wake Forest School of Medicine, Winston- Salem, North Carolina, USA; Department of Internal Medicine, Section on Nephrology; Wake Forest School of Medicine, Winston-Salem, North Carolina, USA. Wake Forest University Health Sciences and BIF have rights to an issued US patent related to APOL1 genetic testing (www.apol1genetest.com). Dr. Freedman is a consultant for AstraZeneca Pharmaceuticals and Renalytix AI. Address correspondence to Dr. Gisele Vajgel (@gvajgel) Division of Nephrology, Hospital das Clinicas, Federal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil Av. Prof Moraes Rego, 1235. Cidade Universitaria Recife PE – Brazil ZIP: 50670-901. E-mail: giselevajgel@hotmail.com
Paula Sandrin-Garcia
From the Division of Nephrology, Hospital das Clinicas, Federal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil; Molecular Biology Laboratory, Keizo Asami Immunopathology Laboratory (LIKA), Federal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil; Division of Nephrology, Instituto de Medicina Integral Prof Fernando Figueira (IMIP), Recife, Pernambuco, Brazil; Division of Public Health Sciences, Department of Biostatistical Sciences; Wake Forest School of Medicine, Winston-Salem, North Carolina, USA; Division of Nephrology, Department of Medicine, Federal University of São Paulo (UNIFESP), São Paulo, Brazil; Center for Diabetes Research; Wake Forest School of Medicine, Winston- Salem, North Carolina, USA; Department of Internal Medicine, Section on Nephrology; Wake Forest School of Medicine, Winston-Salem, North Carolina, USA. Wake Forest University Health Sciences and BIF have rights to an issued US patent related to APOL1 genetic testing (www.apol1genetest.com). Dr. Freedman is a consultant for AstraZeneca Pharmaceuticals and Renalytix AI. Address correspondence to Dr. Gisele Vajgel (@gvajgel) Division of Nephrology, Hospital das Clinicas, Federal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil Av. Prof Moraes Rego, 1235. Cidade Universitaria Recife PE – Brazil ZIP: 50670-901. E-mail: giselevajgel@hotmail.com
In this issue
The Journal of Rheumatology
Vol. 51, Issue 3
1 Mar 2024
Accepted manuscript
A single APOL1 nephropathy variant increases risk of advanced lupus nephritis in Brazilians
Gisele Vajgel, Suelen Cristina Lima, Diego Jeronimo S. Santana, Camila B. L. Oliveira, Denise Maria N. Costa, Pamela J. Hicks, Maria Alina G. M. Cavalcante, Carl D. Langefeld, Lucila Maria Valente, Sergio Crovella, Gianna Mastroianni Kirsztajn, Barry I. Freedman, Paula Sandrin-Garcia
The Journal of Rheumatology Nov 2019, jrheum.190684; DOI: 10.3899/jrheum.190684
Accepted manuscript
A single APOL1 nephropathy variant increases risk of advanced lupus nephritis in Brazilians
Gisele Vajgel, Suelen Cristina Lima, Diego Jeronimo S. Santana, Camila B. L. Oliveira, Denise Maria N. Costa, Pamela J. Hicks, Maria Alina G. M. Cavalcante, Carl D. Langefeld, Lucila Maria Valente, Sergio Crovella, Gianna Mastroianni Kirsztajn, Barry I. Freedman, Paula Sandrin-Garcia
The Journal of Rheumatology Nov 2019, jrheum.190684; DOI: 10.3899/jrheum.190684