Research ArticleArticle
Secukinumab Immunogenicity over 52 Weeks in Patients with Psoriatic Arthritis and Ankylosing Spondylitis
Atul Deodhar, Dafna D. Gladman, Iain B. McInnes, Sebastian Spindeldreher, Ruvie Martin, Luminita Pricop, Brian Porter, Jorge Safi Jr., Abhijit Shete and Gerard Bruin
The Journal of Rheumatology June 2019, jrheum.190116; DOI: https://doi.org/10.3899/jrheum.190116
Atul Deodhar
From the Division of Arthritis & Rheumatic Diseases, Rheumatology Clinics, Oregon Health & Science University, Portland, Oregon, USA; Health Network, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Toronto, Ontario, Canada; Centre for Rheumatic Diseases, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK; PKS Bioanalytics, Novartis Institutes for Biomedical Research, Basel; Immunology and Dermatology, Novartis Pharma AG, Basel, Switzerland; Immunology and Dermatology, Novartis Pharmaceuticals Corp., East Hanover, New Jersey, USA. This study was funded by Novartis Pharmaceuticals Corp., USA, which manufactures secukinumab. AD reports grants and personal fees from Novartis, Eli Lilly, Janssen, Pfizer, and UCB, and grants from Amgen, AbbVie, and GSK during the conduct of the study. DDG reports grants from Novartis during the conduct of the study. IBM reports grants and personal fees from Novartis during the conduct of the study. SS and GB are employees and shareholders of Novartis Institutes for Biomedical Research; RM, LP, BP, JS, and AS are employees and shareholders of Novartis Pharma AG. A. Deodhar, MD, Professor of Medicine, Division of Arthritis & Rheumatic Diseases, Rheumatology Clinics, Oregon Health & Science University; D.D. Gladman, MD, FRCPC, University Health Network, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital; I.B. McInnes, MD, PhD, Centre for Rheumatic Diseases, Institute of Infection, Immunity and Inflammation, University of Glasgow; S. Spindeldreher, PhD, PKS Bioanalytics, Novartis Institutes for Biomedical Research; R. Martin, PhD, Immunology and Dermatology, Novartis Pharmaceuticals Corp.; L. Pricop, MD, Immunology and Dermatology, Novartis Pharmaceuticals Corp.; B. Porter, MD, PhD, MPH, MBA, Immunology and Dermatology, Novartis Pharmaceuticals Corp.; J. Safi Jr., MD, PhD, Immunology and Dermatology, Novartis Pharmaceuticals Corp.; A. Shete MD, Immunology and Dermatology, Novartis Pharma AG; G. Bruin, PhD, PKS Bioanalytics, Novartis Institutes for Biomedical Research. Address correspondence to Dr. A. Deodhar, Medical Director, Rheumatology Clinics, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA. E-mail: deodhara@ohsu.edu Accepted for publication May 27, 2019.
Dafna D. Gladman
From the Division of Arthritis & Rheumatic Diseases, Rheumatology Clinics, Oregon Health & Science University, Portland, Oregon, USA; Health Network, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Toronto, Ontario, Canada; Centre for Rheumatic Diseases, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK; PKS Bioanalytics, Novartis Institutes for Biomedical Research, Basel; Immunology and Dermatology, Novartis Pharma AG, Basel, Switzerland; Immunology and Dermatology, Novartis Pharmaceuticals Corp., East Hanover, New Jersey, USA. This study was funded by Novartis Pharmaceuticals Corp., USA, which manufactures secukinumab. AD reports grants and personal fees from Novartis, Eli Lilly, Janssen, Pfizer, and UCB, and grants from Amgen, AbbVie, and GSK during the conduct of the study. DDG reports grants from Novartis during the conduct of the study. IBM reports grants and personal fees from Novartis during the conduct of the study. SS and GB are employees and shareholders of Novartis Institutes for Biomedical Research; RM, LP, BP, JS, and AS are employees and shareholders of Novartis Pharma AG. A. Deodhar, MD, Professor of Medicine, Division of Arthritis & Rheumatic Diseases, Rheumatology Clinics, Oregon Health & Science University; D.D. Gladman, MD, FRCPC, University Health Network, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital; I.B. McInnes, MD, PhD, Centre for Rheumatic Diseases, Institute of Infection, Immunity and Inflammation, University of Glasgow; S. Spindeldreher, PhD, PKS Bioanalytics, Novartis Institutes for Biomedical Research; R. Martin, PhD, Immunology and Dermatology, Novartis Pharmaceuticals Corp.; L. Pricop, MD, Immunology and Dermatology, Novartis Pharmaceuticals Corp.; B. Porter, MD, PhD, MPH, MBA, Immunology and Dermatology, Novartis Pharmaceuticals Corp.; J. Safi Jr., MD, PhD, Immunology and Dermatology, Novartis Pharmaceuticals Corp.; A. Shete MD, Immunology and Dermatology, Novartis Pharma AG; G. Bruin, PhD, PKS Bioanalytics, Novartis Institutes for Biomedical Research. Address correspondence to Dr. A. Deodhar, Medical Director, Rheumatology Clinics, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA. E-mail: deodhara@ohsu.edu Accepted for publication May 27, 2019.
Iain B. McInnes
From the Division of Arthritis & Rheumatic Diseases, Rheumatology Clinics, Oregon Health & Science University, Portland, Oregon, USA; Health Network, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Toronto, Ontario, Canada; Centre for Rheumatic Diseases, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK; PKS Bioanalytics, Novartis Institutes for Biomedical Research, Basel; Immunology and Dermatology, Novartis Pharma AG, Basel, Switzerland; Immunology and Dermatology, Novartis Pharmaceuticals Corp., East Hanover, New Jersey, USA. This study was funded by Novartis Pharmaceuticals Corp., USA, which manufactures secukinumab. AD reports grants and personal fees from Novartis, Eli Lilly, Janssen, Pfizer, and UCB, and grants from Amgen, AbbVie, and GSK during the conduct of the study. DDG reports grants from Novartis during the conduct of the study. IBM reports grants and personal fees from Novartis during the conduct of the study. SS and GB are employees and shareholders of Novartis Institutes for Biomedical Research; RM, LP, BP, JS, and AS are employees and shareholders of Novartis Pharma AG. A. Deodhar, MD, Professor of Medicine, Division of Arthritis & Rheumatic Diseases, Rheumatology Clinics, Oregon Health & Science University; D.D. Gladman, MD, FRCPC, University Health Network, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital; I.B. McInnes, MD, PhD, Centre for Rheumatic Diseases, Institute of Infection, Immunity and Inflammation, University of Glasgow; S. Spindeldreher, PhD, PKS Bioanalytics, Novartis Institutes for Biomedical Research; R. Martin, PhD, Immunology and Dermatology, Novartis Pharmaceuticals Corp.; L. Pricop, MD, Immunology and Dermatology, Novartis Pharmaceuticals Corp.; B. Porter, MD, PhD, MPH, MBA, Immunology and Dermatology, Novartis Pharmaceuticals Corp.; J. Safi Jr., MD, PhD, Immunology and Dermatology, Novartis Pharmaceuticals Corp.; A. Shete MD, Immunology and Dermatology, Novartis Pharma AG; G. Bruin, PhD, PKS Bioanalytics, Novartis Institutes for Biomedical Research. Address correspondence to Dr. A. Deodhar, Medical Director, Rheumatology Clinics, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA. E-mail: deodhara@ohsu.edu Accepted for publication May 27, 2019.
Sebastian Spindeldreher
From the Division of Arthritis & Rheumatic Diseases, Rheumatology Clinics, Oregon Health & Science University, Portland, Oregon, USA; Health Network, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Toronto, Ontario, Canada; Centre for Rheumatic Diseases, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK; PKS Bioanalytics, Novartis Institutes for Biomedical Research, Basel; Immunology and Dermatology, Novartis Pharma AG, Basel, Switzerland; Immunology and Dermatology, Novartis Pharmaceuticals Corp., East Hanover, New Jersey, USA. This study was funded by Novartis Pharmaceuticals Corp., USA, which manufactures secukinumab. AD reports grants and personal fees from Novartis, Eli Lilly, Janssen, Pfizer, and UCB, and grants from Amgen, AbbVie, and GSK during the conduct of the study. DDG reports grants from Novartis during the conduct of the study. IBM reports grants and personal fees from Novartis during the conduct of the study. SS and GB are employees and shareholders of Novartis Institutes for Biomedical Research; RM, LP, BP, JS, and AS are employees and shareholders of Novartis Pharma AG. A. Deodhar, MD, Professor of Medicine, Division of Arthritis & Rheumatic Diseases, Rheumatology Clinics, Oregon Health & Science University; D.D. Gladman, MD, FRCPC, University Health Network, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital; I.B. McInnes, MD, PhD, Centre for Rheumatic Diseases, Institute of Infection, Immunity and Inflammation, University of Glasgow; S. Spindeldreher, PhD, PKS Bioanalytics, Novartis Institutes for Biomedical Research; R. Martin, PhD, Immunology and Dermatology, Novartis Pharmaceuticals Corp.; L. Pricop, MD, Immunology and Dermatology, Novartis Pharmaceuticals Corp.; B. Porter, MD, PhD, MPH, MBA, Immunology and Dermatology, Novartis Pharmaceuticals Corp.; J. Safi Jr., MD, PhD, Immunology and Dermatology, Novartis Pharmaceuticals Corp.; A. Shete MD, Immunology and Dermatology, Novartis Pharma AG; G. Bruin, PhD, PKS Bioanalytics, Novartis Institutes for Biomedical Research. Address correspondence to Dr. A. Deodhar, Medical Director, Rheumatology Clinics, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA. E-mail: deodhara@ohsu.edu Accepted for publication May 27, 2019.
Ruvie Martin
From the Division of Arthritis & Rheumatic Diseases, Rheumatology Clinics, Oregon Health & Science University, Portland, Oregon, USA; Health Network, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Toronto, Ontario, Canada; Centre for Rheumatic Diseases, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK; PKS Bioanalytics, Novartis Institutes for Biomedical Research, Basel; Immunology and Dermatology, Novartis Pharma AG, Basel, Switzerland; Immunology and Dermatology, Novartis Pharmaceuticals Corp., East Hanover, New Jersey, USA. This study was funded by Novartis Pharmaceuticals Corp., USA, which manufactures secukinumab. AD reports grants and personal fees from Novartis, Eli Lilly, Janssen, Pfizer, and UCB, and grants from Amgen, AbbVie, and GSK during the conduct of the study. DDG reports grants from Novartis during the conduct of the study. IBM reports grants and personal fees from Novartis during the conduct of the study. SS and GB are employees and shareholders of Novartis Institutes for Biomedical Research; RM, LP, BP, JS, and AS are employees and shareholders of Novartis Pharma AG. A. Deodhar, MD, Professor of Medicine, Division of Arthritis & Rheumatic Diseases, Rheumatology Clinics, Oregon Health & Science University; D.D. Gladman, MD, FRCPC, University Health Network, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital; I.B. McInnes, MD, PhD, Centre for Rheumatic Diseases, Institute of Infection, Immunity and Inflammation, University of Glasgow; S. Spindeldreher, PhD, PKS Bioanalytics, Novartis Institutes for Biomedical Research; R. Martin, PhD, Immunology and Dermatology, Novartis Pharmaceuticals Corp.; L. Pricop, MD, Immunology and Dermatology, Novartis Pharmaceuticals Corp.; B. Porter, MD, PhD, MPH, MBA, Immunology and Dermatology, Novartis Pharmaceuticals Corp.; J. Safi Jr., MD, PhD, Immunology and Dermatology, Novartis Pharmaceuticals Corp.; A. Shete MD, Immunology and Dermatology, Novartis Pharma AG; G. Bruin, PhD, PKS Bioanalytics, Novartis Institutes for Biomedical Research. Address correspondence to Dr. A. Deodhar, Medical Director, Rheumatology Clinics, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA. E-mail: deodhara@ohsu.edu Accepted for publication May 27, 2019.
Luminita Pricop
From the Division of Arthritis & Rheumatic Diseases, Rheumatology Clinics, Oregon Health & Science University, Portland, Oregon, USA; Health Network, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Toronto, Ontario, Canada; Centre for Rheumatic Diseases, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK; PKS Bioanalytics, Novartis Institutes for Biomedical Research, Basel; Immunology and Dermatology, Novartis Pharma AG, Basel, Switzerland; Immunology and Dermatology, Novartis Pharmaceuticals Corp., East Hanover, New Jersey, USA. This study was funded by Novartis Pharmaceuticals Corp., USA, which manufactures secukinumab. AD reports grants and personal fees from Novartis, Eli Lilly, Janssen, Pfizer, and UCB, and grants from Amgen, AbbVie, and GSK during the conduct of the study. DDG reports grants from Novartis during the conduct of the study. IBM reports grants and personal fees from Novartis during the conduct of the study. SS and GB are employees and shareholders of Novartis Institutes for Biomedical Research; RM, LP, BP, JS, and AS are employees and shareholders of Novartis Pharma AG. A. Deodhar, MD, Professor of Medicine, Division of Arthritis & Rheumatic Diseases, Rheumatology Clinics, Oregon Health & Science University; D.D. Gladman, MD, FRCPC, University Health Network, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital; I.B. McInnes, MD, PhD, Centre for Rheumatic Diseases, Institute of Infection, Immunity and Inflammation, University of Glasgow; S. Spindeldreher, PhD, PKS Bioanalytics, Novartis Institutes for Biomedical Research; R. Martin, PhD, Immunology and Dermatology, Novartis Pharmaceuticals Corp.; L. Pricop, MD, Immunology and Dermatology, Novartis Pharmaceuticals Corp.; B. Porter, MD, PhD, MPH, MBA, Immunology and Dermatology, Novartis Pharmaceuticals Corp.; J. Safi Jr., MD, PhD, Immunology and Dermatology, Novartis Pharmaceuticals Corp.; A. Shete MD, Immunology and Dermatology, Novartis Pharma AG; G. Bruin, PhD, PKS Bioanalytics, Novartis Institutes for Biomedical Research. Address correspondence to Dr. A. Deodhar, Medical Director, Rheumatology Clinics, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA. E-mail: deodhara@ohsu.edu Accepted for publication May 27, 2019.
Brian Porter
From the Division of Arthritis & Rheumatic Diseases, Rheumatology Clinics, Oregon Health & Science University, Portland, Oregon, USA; Health Network, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Toronto, Ontario, Canada; Centre for Rheumatic Diseases, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK; PKS Bioanalytics, Novartis Institutes for Biomedical Research, Basel; Immunology and Dermatology, Novartis Pharma AG, Basel, Switzerland; Immunology and Dermatology, Novartis Pharmaceuticals Corp., East Hanover, New Jersey, USA. This study was funded by Novartis Pharmaceuticals Corp., USA, which manufactures secukinumab. AD reports grants and personal fees from Novartis, Eli Lilly, Janssen, Pfizer, and UCB, and grants from Amgen, AbbVie, and GSK during the conduct of the study. DDG reports grants from Novartis during the conduct of the study. IBM reports grants and personal fees from Novartis during the conduct of the study. SS and GB are employees and shareholders of Novartis Institutes for Biomedical Research; RM, LP, BP, JS, and AS are employees and shareholders of Novartis Pharma AG. A. Deodhar, MD, Professor of Medicine, Division of Arthritis & Rheumatic Diseases, Rheumatology Clinics, Oregon Health & Science University; D.D. Gladman, MD, FRCPC, University Health Network, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital; I.B. McInnes, MD, PhD, Centre for Rheumatic Diseases, Institute of Infection, Immunity and Inflammation, University of Glasgow; S. Spindeldreher, PhD, PKS Bioanalytics, Novartis Institutes for Biomedical Research; R. Martin, PhD, Immunology and Dermatology, Novartis Pharmaceuticals Corp.; L. Pricop, MD, Immunology and Dermatology, Novartis Pharmaceuticals Corp.; B. Porter, MD, PhD, MPH, MBA, Immunology and Dermatology, Novartis Pharmaceuticals Corp.; J. Safi Jr., MD, PhD, Immunology and Dermatology, Novartis Pharmaceuticals Corp.; A. Shete MD, Immunology and Dermatology, Novartis Pharma AG; G. Bruin, PhD, PKS Bioanalytics, Novartis Institutes for Biomedical Research. Address correspondence to Dr. A. Deodhar, Medical Director, Rheumatology Clinics, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA. E-mail: deodhara@ohsu.edu Accepted for publication May 27, 2019.
Jorge Safi Jr.
From the Division of Arthritis & Rheumatic Diseases, Rheumatology Clinics, Oregon Health & Science University, Portland, Oregon, USA; Health Network, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Toronto, Ontario, Canada; Centre for Rheumatic Diseases, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK; PKS Bioanalytics, Novartis Institutes for Biomedical Research, Basel; Immunology and Dermatology, Novartis Pharma AG, Basel, Switzerland; Immunology and Dermatology, Novartis Pharmaceuticals Corp., East Hanover, New Jersey, USA. This study was funded by Novartis Pharmaceuticals Corp., USA, which manufactures secukinumab. AD reports grants and personal fees from Novartis, Eli Lilly, Janssen, Pfizer, and UCB, and grants from Amgen, AbbVie, and GSK during the conduct of the study. DDG reports grants from Novartis during the conduct of the study. IBM reports grants and personal fees from Novartis during the conduct of the study. SS and GB are employees and shareholders of Novartis Institutes for Biomedical Research; RM, LP, BP, JS, and AS are employees and shareholders of Novartis Pharma AG. A. Deodhar, MD, Professor of Medicine, Division of Arthritis & Rheumatic Diseases, Rheumatology Clinics, Oregon Health & Science University; D.D. Gladman, MD, FRCPC, University Health Network, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital; I.B. McInnes, MD, PhD, Centre for Rheumatic Diseases, Institute of Infection, Immunity and Inflammation, University of Glasgow; S. Spindeldreher, PhD, PKS Bioanalytics, Novartis Institutes for Biomedical Research; R. Martin, PhD, Immunology and Dermatology, Novartis Pharmaceuticals Corp.; L. Pricop, MD, Immunology and Dermatology, Novartis Pharmaceuticals Corp.; B. Porter, MD, PhD, MPH, MBA, Immunology and Dermatology, Novartis Pharmaceuticals Corp.; J. Safi Jr., MD, PhD, Immunology and Dermatology, Novartis Pharmaceuticals Corp.; A. Shete MD, Immunology and Dermatology, Novartis Pharma AG; G. Bruin, PhD, PKS Bioanalytics, Novartis Institutes for Biomedical Research. Address correspondence to Dr. A. Deodhar, Medical Director, Rheumatology Clinics, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA. E-mail: deodhara@ohsu.edu Accepted for publication May 27, 2019.
Abhijit Shete
From the Division of Arthritis & Rheumatic Diseases, Rheumatology Clinics, Oregon Health & Science University, Portland, Oregon, USA; Health Network, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Toronto, Ontario, Canada; Centre for Rheumatic Diseases, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK; PKS Bioanalytics, Novartis Institutes for Biomedical Research, Basel; Immunology and Dermatology, Novartis Pharma AG, Basel, Switzerland; Immunology and Dermatology, Novartis Pharmaceuticals Corp., East Hanover, New Jersey, USA. This study was funded by Novartis Pharmaceuticals Corp., USA, which manufactures secukinumab. AD reports grants and personal fees from Novartis, Eli Lilly, Janssen, Pfizer, and UCB, and grants from Amgen, AbbVie, and GSK during the conduct of the study. DDG reports grants from Novartis during the conduct of the study. IBM reports grants and personal fees from Novartis during the conduct of the study. SS and GB are employees and shareholders of Novartis Institutes for Biomedical Research; RM, LP, BP, JS, and AS are employees and shareholders of Novartis Pharma AG. A. Deodhar, MD, Professor of Medicine, Division of Arthritis & Rheumatic Diseases, Rheumatology Clinics, Oregon Health & Science University; D.D. Gladman, MD, FRCPC, University Health Network, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital; I.B. McInnes, MD, PhD, Centre for Rheumatic Diseases, Institute of Infection, Immunity and Inflammation, University of Glasgow; S. Spindeldreher, PhD, PKS Bioanalytics, Novartis Institutes for Biomedical Research; R. Martin, PhD, Immunology and Dermatology, Novartis Pharmaceuticals Corp.; L. Pricop, MD, Immunology and Dermatology, Novartis Pharmaceuticals Corp.; B. Porter, MD, PhD, MPH, MBA, Immunology and Dermatology, Novartis Pharmaceuticals Corp.; J. Safi Jr., MD, PhD, Immunology and Dermatology, Novartis Pharmaceuticals Corp.; A. Shete MD, Immunology and Dermatology, Novartis Pharma AG; G. Bruin, PhD, PKS Bioanalytics, Novartis Institutes for Biomedical Research. Address correspondence to Dr. A. Deodhar, Medical Director, Rheumatology Clinics, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA. E-mail: deodhara@ohsu.edu Accepted for publication May 27, 2019.
Gerard Bruin
From the Division of Arthritis & Rheumatic Diseases, Rheumatology Clinics, Oregon Health & Science University, Portland, Oregon, USA; Health Network, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Toronto, Ontario, Canada; Centre for Rheumatic Diseases, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK; PKS Bioanalytics, Novartis Institutes for Biomedical Research, Basel; Immunology and Dermatology, Novartis Pharma AG, Basel, Switzerland; Immunology and Dermatology, Novartis Pharmaceuticals Corp., East Hanover, New Jersey, USA. This study was funded by Novartis Pharmaceuticals Corp., USA, which manufactures secukinumab. AD reports grants and personal fees from Novartis, Eli Lilly, Janssen, Pfizer, and UCB, and grants from Amgen, AbbVie, and GSK during the conduct of the study. DDG reports grants from Novartis during the conduct of the study. IBM reports grants and personal fees from Novartis during the conduct of the study. SS and GB are employees and shareholders of Novartis Institutes for Biomedical Research; RM, LP, BP, JS, and AS are employees and shareholders of Novartis Pharma AG. A. Deodhar, MD, Professor of Medicine, Division of Arthritis & Rheumatic Diseases, Rheumatology Clinics, Oregon Health & Science University; D.D. Gladman, MD, FRCPC, University Health Network, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital; I.B. McInnes, MD, PhD, Centre for Rheumatic Diseases, Institute of Infection, Immunity and Inflammation, University of Glasgow; S. Spindeldreher, PhD, PKS Bioanalytics, Novartis Institutes for Biomedical Research; R. Martin, PhD, Immunology and Dermatology, Novartis Pharmaceuticals Corp.; L. Pricop, MD, Immunology and Dermatology, Novartis Pharmaceuticals Corp.; B. Porter, MD, PhD, MPH, MBA, Immunology and Dermatology, Novartis Pharmaceuticals Corp.; J. Safi Jr., MD, PhD, Immunology and Dermatology, Novartis Pharmaceuticals Corp.; A. Shete MD, Immunology and Dermatology, Novartis Pharma AG; G. Bruin, PhD, PKS Bioanalytics, Novartis Institutes for Biomedical Research. Address correspondence to Dr. A. Deodhar, Medical Director, Rheumatology Clinics, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA. E-mail: deodhara@ohsu.edu Accepted for publication May 27, 2019.
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- Published online November 15, 2019.
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- Atul Deodhar,
- Dafna D. Gladman,
- Iain B. McInnes,
- Sebastian Spindeldreher,
- Ruvie Martin,
- Luminita Pricop,
- Brian Porter,
- Jorge Safi Jr.,
- Abhijit Shete and
- Gerard Bruin
- From the Division of Arthritis & Rheumatic Diseases, Rheumatology Clinics, Oregon Health & Science University, Portland, Oregon, USA; Health Network, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Toronto, Ontario, Canada; Centre for Rheumatic Diseases, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK; PKS Bioanalytics, Novartis Institutes for Biomedical Research, Basel; Immunology and Dermatology, Novartis Pharma AG, Basel, Switzerland; Immunology and Dermatology, Novartis Pharmaceuticals Corp., East Hanover, New Jersey, USA.
This study was funded by Novartis Pharmaceuticals Corp., USA, which manufactures secukinumab.
AD reports grants and personal fees from Novartis, Eli Lilly, Janssen, Pfizer, and UCB, and grants from Amgen, AbbVie, and GSK during the conduct of the study. DDG reports grants from Novartis during the conduct of the study. IBM reports grants and personal fees from Novartis during the conduct of the study. SS and GB are employees and shareholders of Novartis Institutes for Biomedical Research; RM, LP, BP, JS, and AS are employees and shareholders of Novartis Pharma AG. A. Deodhar, MD, Professor of Medicine, Division of Arthritis & Rheumatic Diseases, Rheumatology Clinics, Oregon Health & Science University; D.D. Gladman, MD, FRCPC, University Health Network, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital; I.B. McInnes, MD, PhD, Centre for Rheumatic Diseases, Institute of Infection, Immunity and Inflammation, University of Glasgow; S. Spindeldreher, PhD, PKS Bioanalytics, Novartis Institutes for Biomedical Research; R. Martin, PhD, Immunology and Dermatology, Novartis Pharmaceuticals Corp.; L. Pricop, MD, Immunology and Dermatology, Novartis Pharmaceuticals Corp.; B. Porter, MD, PhD, MPH, MBA, Immunology and Dermatology, Novartis Pharmaceuticals Corp.; J. Safi Jr., MD, PhD, Immunology and Dermatology, Novartis Pharmaceuticals Corp.; A. Shete MD, Immunology and Dermatology, Novartis Pharma AG; G. Bruin, PhD, PKS Bioanalytics, Novartis Institutes for Biomedical Research.
Address correspondence to Dr. A. Deodhar, Medical Director, Rheumatology Clinics, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA. E-mail: deodhara@ohsu.edu
Accepted for publication May 27, 2019.
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The Journal of Rheumatology
Vol. 51, Issue 3
1 Mar 2024
Secukinumab Immunogenicity over 52 Weeks in Patients with Psoriatic Arthritis and Ankylosing Spondylitis
Atul Deodhar, Dafna D. Gladman, Iain B. McInnes, Sebastian Spindeldreher, Ruvie Martin, Luminita Pricop, Brian Porter, Jorge Safi , Abhijit Shete, Gerard Bruin
The Journal of Rheumatology Jun 2019, jrheum.190116; DOI: 10.3899/jrheum.190116
Secukinumab Immunogenicity over 52 Weeks in Patients with Psoriatic Arthritis and Ankylosing Spondylitis
Atul Deodhar, Dafna D. Gladman, Iain B. McInnes, Sebastian Spindeldreher, Ruvie Martin, Luminita Pricop, Brian Porter, Jorge Safi , Abhijit Shete, Gerard Bruin
The Journal of Rheumatology Jun 2019, jrheum.190116; DOI: 10.3899/jrheum.190116