Research ArticleAccepted Article
Analysis of 47 non-MHC Ankylosing Spondylitis Susceptibility Loci Reveals Shared Associated Variants across Caucasians and Han Chinese
Xuqi Zheng, Qiuxia Li, Xiaomin Li, Yanli Zhang, Xinyu Wu, Qiujing Wei, Shuangyan Cao, Mingcan Yang, Zhiming Lin, Zetao Liao, Jun Qi, Qing Lv, Ling Wang, Yi Li, Astrid Irwanto, Ching-Yu Cheng, Xiaoran Chai, Chiea Chuen Khor, Chew-Kiat Heng, Woon-Puay Koh, Jian-Min Yuan, Jinxin Bei, Furen Zhang, Xuejun Zhang, Yixin Zeng, Yan Shen, Jianjun Liu and Jieruo Gu
The Journal of Rheumatology September 2019, jrheum.190184; DOI: https://doi.org/10.3899/jrheum.190184
Xuqi Zheng
From the Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen Universiy; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR);the Jackson Laboratory,USA; the Singapore Eye Research Institute (SERI);the Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), the Health Systems and Services Research, Duke-NUS Medical School; the department of Ophthalmology, the department of Paediatrics,Yong Loo Lin School of Medicine;the Khoo Teck Puat - National University Children's Medical Institute; the Saw Swee Hock School of Public Health, National University of Singapore; the division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, the department of Epidemiology, Graduate School of Public Health, University of Pittsburgh; the State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center;the Shandong Provincial Institute of Dermatology and Venereology & Hospital for Skin Diseases, Shandong First Medical University & Shandong Academy of Medical Sciences; the National Clinical Key Project of Dermatology and Venereology;the Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University;the Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University; the Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University);the National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College. Supported by the Science and Technology Planning Project of Guangdong Province,China (2016A020216013),the Guangdong Natural Science Funds for Distinguished Young Scholar (Grant No.2014A030306039), the Municipal Healthcare Joint-Innovation Major Project of Guangzhou and High-level personnel of special support program for Technology Innovative Talents and the Top Young of Guangdong Province (Grant No.2015TQ01R516),the National Supercomputer Center in Guangzhou and the Agency of Science, Technology and Research (A*STAR) of Singapore, the HUJ-CREATE Programme of the National Research Foundation, Singapore (Project Number 370062002), the U.S. National Institutes of Health (Grant Numbers R01CA144034 and UM1 CA182876), the Singapore National Medical Research Council(Grant Number 1270/2010), the 5010 Project of Sun Yat-sen University(Grant No.2007023), Distinguished Young Scholar Candidates Programme for The Third Affiliated Hospital of Sun Yat-Sen University and Pearl River Nova Program of Guangzhou (Grant No. 201610010005). Address Correspondence to Prof. J Gu, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen Universiy, Guangzhou 510630, China; Email:gujieruo@163.com or Prof. J. Liu, Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138672; Email: liuj3@gis.a-star.edu.sg
Qiuxia Li
From the Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen Universiy; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR);the Jackson Laboratory,USA; the Singapore Eye Research Institute (SERI);the Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), the Health Systems and Services Research, Duke-NUS Medical School; the department of Ophthalmology, the department of Paediatrics,Yong Loo Lin School of Medicine;the Khoo Teck Puat - National University Children's Medical Institute; the Saw Swee Hock School of Public Health, National University of Singapore; the division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, the department of Epidemiology, Graduate School of Public Health, University of Pittsburgh; the State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center;the Shandong Provincial Institute of Dermatology and Venereology & Hospital for Skin Diseases, Shandong First Medical University & Shandong Academy of Medical Sciences; the National Clinical Key Project of Dermatology and Venereology;the Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University;the Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University; the Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University);the National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College. Supported by the Science and Technology Planning Project of Guangdong Province,China (2016A020216013),the Guangdong Natural Science Funds for Distinguished Young Scholar (Grant No.2014A030306039), the Municipal Healthcare Joint-Innovation Major Project of Guangzhou and High-level personnel of special support program for Technology Innovative Talents and the Top Young of Guangdong Province (Grant No.2015TQ01R516),the National Supercomputer Center in Guangzhou and the Agency of Science, Technology and Research (A*STAR) of Singapore, the HUJ-CREATE Programme of the National Research Foundation, Singapore (Project Number 370062002), the U.S. National Institutes of Health (Grant Numbers R01CA144034 and UM1 CA182876), the Singapore National Medical Research Council(Grant Number 1270/2010), the 5010 Project of Sun Yat-sen University(Grant No.2007023), Distinguished Young Scholar Candidates Programme for The Third Affiliated Hospital of Sun Yat-Sen University and Pearl River Nova Program of Guangzhou (Grant No. 201610010005). Address Correspondence to Prof. J Gu, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen Universiy, Guangzhou 510630, China; Email:gujieruo@163.com or Prof. J. Liu, Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138672; Email: liuj3@gis.a-star.edu.sg
Xiaomin Li
From the Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen Universiy; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR);the Jackson Laboratory,USA; the Singapore Eye Research Institute (SERI);the Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), the Health Systems and Services Research, Duke-NUS Medical School; the department of Ophthalmology, the department of Paediatrics,Yong Loo Lin School of Medicine;the Khoo Teck Puat - National University Children's Medical Institute; the Saw Swee Hock School of Public Health, National University of Singapore; the division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, the department of Epidemiology, Graduate School of Public Health, University of Pittsburgh; the State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center;the Shandong Provincial Institute of Dermatology and Venereology & Hospital for Skin Diseases, Shandong First Medical University & Shandong Academy of Medical Sciences; the National Clinical Key Project of Dermatology and Venereology;the Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University;the Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University; the Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University);the National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College. Supported by the Science and Technology Planning Project of Guangdong Province,China (2016A020216013),the Guangdong Natural Science Funds for Distinguished Young Scholar (Grant No.2014A030306039), the Municipal Healthcare Joint-Innovation Major Project of Guangzhou and High-level personnel of special support program for Technology Innovative Talents and the Top Young of Guangdong Province (Grant No.2015TQ01R516),the National Supercomputer Center in Guangzhou and the Agency of Science, Technology and Research (A*STAR) of Singapore, the HUJ-CREATE Programme of the National Research Foundation, Singapore (Project Number 370062002), the U.S. National Institutes of Health (Grant Numbers R01CA144034 and UM1 CA182876), the Singapore National Medical Research Council(Grant Number 1270/2010), the 5010 Project of Sun Yat-sen University(Grant No.2007023), Distinguished Young Scholar Candidates Programme for The Third Affiliated Hospital of Sun Yat-Sen University and Pearl River Nova Program of Guangzhou (Grant No. 201610010005). Address Correspondence to Prof. J Gu, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen Universiy, Guangzhou 510630, China; Email:gujieruo@163.com or Prof. J. Liu, Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138672; Email: liuj3@gis.a-star.edu.sg
Yanli Zhang
From the Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen Universiy; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR);the Jackson Laboratory,USA; the Singapore Eye Research Institute (SERI);the Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), the Health Systems and Services Research, Duke-NUS Medical School; the department of Ophthalmology, the department of Paediatrics,Yong Loo Lin School of Medicine;the Khoo Teck Puat - National University Children's Medical Institute; the Saw Swee Hock School of Public Health, National University of Singapore; the division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, the department of Epidemiology, Graduate School of Public Health, University of Pittsburgh; the State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center;the Shandong Provincial Institute of Dermatology and Venereology & Hospital for Skin Diseases, Shandong First Medical University & Shandong Academy of Medical Sciences; the National Clinical Key Project of Dermatology and Venereology;the Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University;the Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University; the Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University);the National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College. Supported by the Science and Technology Planning Project of Guangdong Province,China (2016A020216013),the Guangdong Natural Science Funds for Distinguished Young Scholar (Grant No.2014A030306039), the Municipal Healthcare Joint-Innovation Major Project of Guangzhou and High-level personnel of special support program for Technology Innovative Talents and the Top Young of Guangdong Province (Grant No.2015TQ01R516),the National Supercomputer Center in Guangzhou and the Agency of Science, Technology and Research (A*STAR) of Singapore, the HUJ-CREATE Programme of the National Research Foundation, Singapore (Project Number 370062002), the U.S. National Institutes of Health (Grant Numbers R01CA144034 and UM1 CA182876), the Singapore National Medical Research Council(Grant Number 1270/2010), the 5010 Project of Sun Yat-sen University(Grant No.2007023), Distinguished Young Scholar Candidates Programme for The Third Affiliated Hospital of Sun Yat-Sen University and Pearl River Nova Program of Guangzhou (Grant No. 201610010005). Address Correspondence to Prof. J Gu, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen Universiy, Guangzhou 510630, China; Email:gujieruo@163.com or Prof. J. Liu, Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138672; Email: liuj3@gis.a-star.edu.sg
Xinyu Wu
From the Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen Universiy; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR);the Jackson Laboratory,USA; the Singapore Eye Research Institute (SERI);the Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), the Health Systems and Services Research, Duke-NUS Medical School; the department of Ophthalmology, the department of Paediatrics,Yong Loo Lin School of Medicine;the Khoo Teck Puat - National University Children's Medical Institute; the Saw Swee Hock School of Public Health, National University of Singapore; the division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, the department of Epidemiology, Graduate School of Public Health, University of Pittsburgh; the State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center;the Shandong Provincial Institute of Dermatology and Venereology & Hospital for Skin Diseases, Shandong First Medical University & Shandong Academy of Medical Sciences; the National Clinical Key Project of Dermatology and Venereology;the Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University;the Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University; the Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University);the National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College. Supported by the Science and Technology Planning Project of Guangdong Province,China (2016A020216013),the Guangdong Natural Science Funds for Distinguished Young Scholar (Grant No.2014A030306039), the Municipal Healthcare Joint-Innovation Major Project of Guangzhou and High-level personnel of special support program for Technology Innovative Talents and the Top Young of Guangdong Province (Grant No.2015TQ01R516),the National Supercomputer Center in Guangzhou and the Agency of Science, Technology and Research (A*STAR) of Singapore, the HUJ-CREATE Programme of the National Research Foundation, Singapore (Project Number 370062002), the U.S. National Institutes of Health (Grant Numbers R01CA144034 and UM1 CA182876), the Singapore National Medical Research Council(Grant Number 1270/2010), the 5010 Project of Sun Yat-sen University(Grant No.2007023), Distinguished Young Scholar Candidates Programme for The Third Affiliated Hospital of Sun Yat-Sen University and Pearl River Nova Program of Guangzhou (Grant No. 201610010005). Address Correspondence to Prof. J Gu, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen Universiy, Guangzhou 510630, China; Email:gujieruo@163.com or Prof. J. Liu, Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138672; Email: liuj3@gis.a-star.edu.sg
Qiujing Wei
From the Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen Universiy; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR);the Jackson Laboratory,USA; the Singapore Eye Research Institute (SERI);the Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), the Health Systems and Services Research, Duke-NUS Medical School; the department of Ophthalmology, the department of Paediatrics,Yong Loo Lin School of Medicine;the Khoo Teck Puat - National University Children's Medical Institute; the Saw Swee Hock School of Public Health, National University of Singapore; the division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, the department of Epidemiology, Graduate School of Public Health, University of Pittsburgh; the State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center;the Shandong Provincial Institute of Dermatology and Venereology & Hospital for Skin Diseases, Shandong First Medical University & Shandong Academy of Medical Sciences; the National Clinical Key Project of Dermatology and Venereology;the Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University;the Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University; the Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University);the National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College. Supported by the Science and Technology Planning Project of Guangdong Province,China (2016A020216013),the Guangdong Natural Science Funds for Distinguished Young Scholar (Grant No.2014A030306039), the Municipal Healthcare Joint-Innovation Major Project of Guangzhou and High-level personnel of special support program for Technology Innovative Talents and the Top Young of Guangdong Province (Grant No.2015TQ01R516),the National Supercomputer Center in Guangzhou and the Agency of Science, Technology and Research (A*STAR) of Singapore, the HUJ-CREATE Programme of the National Research Foundation, Singapore (Project Number 370062002), the U.S. National Institutes of Health (Grant Numbers R01CA144034 and UM1 CA182876), the Singapore National Medical Research Council(Grant Number 1270/2010), the 5010 Project of Sun Yat-sen University(Grant No.2007023), Distinguished Young Scholar Candidates Programme for The Third Affiliated Hospital of Sun Yat-Sen University and Pearl River Nova Program of Guangzhou (Grant No. 201610010005). Address Correspondence to Prof. J Gu, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen Universiy, Guangzhou 510630, China; Email:gujieruo@163.com or Prof. J. Liu, Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138672; Email: liuj3@gis.a-star.edu.sg
Shuangyan Cao
From the Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen Universiy; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR);the Jackson Laboratory,USA; the Singapore Eye Research Institute (SERI);the Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), the Health Systems and Services Research, Duke-NUS Medical School; the department of Ophthalmology, the department of Paediatrics,Yong Loo Lin School of Medicine;the Khoo Teck Puat - National University Children's Medical Institute; the Saw Swee Hock School of Public Health, National University of Singapore; the division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, the department of Epidemiology, Graduate School of Public Health, University of Pittsburgh; the State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center;the Shandong Provincial Institute of Dermatology and Venereology & Hospital for Skin Diseases, Shandong First Medical University & Shandong Academy of Medical Sciences; the National Clinical Key Project of Dermatology and Venereology;the Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University;the Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University; the Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University);the National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College. Supported by the Science and Technology Planning Project of Guangdong Province,China (2016A020216013),the Guangdong Natural Science Funds for Distinguished Young Scholar (Grant No.2014A030306039), the Municipal Healthcare Joint-Innovation Major Project of Guangzhou and High-level personnel of special support program for Technology Innovative Talents and the Top Young of Guangdong Province (Grant No.2015TQ01R516),the National Supercomputer Center in Guangzhou and the Agency of Science, Technology and Research (A*STAR) of Singapore, the HUJ-CREATE Programme of the National Research Foundation, Singapore (Project Number 370062002), the U.S. National Institutes of Health (Grant Numbers R01CA144034 and UM1 CA182876), the Singapore National Medical Research Council(Grant Number 1270/2010), the 5010 Project of Sun Yat-sen University(Grant No.2007023), Distinguished Young Scholar Candidates Programme for The Third Affiliated Hospital of Sun Yat-Sen University and Pearl River Nova Program of Guangzhou (Grant No. 201610010005). Address Correspondence to Prof. J Gu, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen Universiy, Guangzhou 510630, China; Email:gujieruo@163.com or Prof. J. Liu, Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138672; Email: liuj3@gis.a-star.edu.sg
Mingcan Yang
From the Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen Universiy; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR);the Jackson Laboratory,USA; the Singapore Eye Research Institute (SERI);the Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), the Health Systems and Services Research, Duke-NUS Medical School; the department of Ophthalmology, the department of Paediatrics,Yong Loo Lin School of Medicine;the Khoo Teck Puat - National University Children's Medical Institute; the Saw Swee Hock School of Public Health, National University of Singapore; the division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, the department of Epidemiology, Graduate School of Public Health, University of Pittsburgh; the State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center;the Shandong Provincial Institute of Dermatology and Venereology & Hospital for Skin Diseases, Shandong First Medical University & Shandong Academy of Medical Sciences; the National Clinical Key Project of Dermatology and Venereology;the Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University;the Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University; the Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University);the National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College. Supported by the Science and Technology Planning Project of Guangdong Province,China (2016A020216013),the Guangdong Natural Science Funds for Distinguished Young Scholar (Grant No.2014A030306039), the Municipal Healthcare Joint-Innovation Major Project of Guangzhou and High-level personnel of special support program for Technology Innovative Talents and the Top Young of Guangdong Province (Grant No.2015TQ01R516),the National Supercomputer Center in Guangzhou and the Agency of Science, Technology and Research (A*STAR) of Singapore, the HUJ-CREATE Programme of the National Research Foundation, Singapore (Project Number 370062002), the U.S. National Institutes of Health (Grant Numbers R01CA144034 and UM1 CA182876), the Singapore National Medical Research Council(Grant Number 1270/2010), the 5010 Project of Sun Yat-sen University(Grant No.2007023), Distinguished Young Scholar Candidates Programme for The Third Affiliated Hospital of Sun Yat-Sen University and Pearl River Nova Program of Guangzhou (Grant No. 201610010005). Address Correspondence to Prof. J Gu, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen Universiy, Guangzhou 510630, China; Email:gujieruo@163.com or Prof. J. Liu, Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138672; Email: liuj3@gis.a-star.edu.sg
Zhiming Lin
From the Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen Universiy; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR);the Jackson Laboratory,USA; the Singapore Eye Research Institute (SERI);the Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), the Health Systems and Services Research, Duke-NUS Medical School; the department of Ophthalmology, the department of Paediatrics,Yong Loo Lin School of Medicine;the Khoo Teck Puat - National University Children's Medical Institute; the Saw Swee Hock School of Public Health, National University of Singapore; the division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, the department of Epidemiology, Graduate School of Public Health, University of Pittsburgh; the State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center;the Shandong Provincial Institute of Dermatology and Venereology & Hospital for Skin Diseases, Shandong First Medical University & Shandong Academy of Medical Sciences; the National Clinical Key Project of Dermatology and Venereology;the Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University;the Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University; the Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University);the National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College. Supported by the Science and Technology Planning Project of Guangdong Province,China (2016A020216013),the Guangdong Natural Science Funds for Distinguished Young Scholar (Grant No.2014A030306039), the Municipal Healthcare Joint-Innovation Major Project of Guangzhou and High-level personnel of special support program for Technology Innovative Talents and the Top Young of Guangdong Province (Grant No.2015TQ01R516),the National Supercomputer Center in Guangzhou and the Agency of Science, Technology and Research (A*STAR) of Singapore, the HUJ-CREATE Programme of the National Research Foundation, Singapore (Project Number 370062002), the U.S. National Institutes of Health (Grant Numbers R01CA144034 and UM1 CA182876), the Singapore National Medical Research Council(Grant Number 1270/2010), the 5010 Project of Sun Yat-sen University(Grant No.2007023), Distinguished Young Scholar Candidates Programme for The Third Affiliated Hospital of Sun Yat-Sen University and Pearl River Nova Program of Guangzhou (Grant No. 201610010005). Address Correspondence to Prof. J Gu, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen Universiy, Guangzhou 510630, China; Email:gujieruo@163.com or Prof. J. Liu, Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138672; Email: liuj3@gis.a-star.edu.sg
Zetao Liao
From the Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen Universiy; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR);the Jackson Laboratory,USA; the Singapore Eye Research Institute (SERI);the Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), the Health Systems and Services Research, Duke-NUS Medical School; the department of Ophthalmology, the department of Paediatrics,Yong Loo Lin School of Medicine;the Khoo Teck Puat - National University Children's Medical Institute; the Saw Swee Hock School of Public Health, National University of Singapore; the division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, the department of Epidemiology, Graduate School of Public Health, University of Pittsburgh; the State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center;the Shandong Provincial Institute of Dermatology and Venereology & Hospital for Skin Diseases, Shandong First Medical University & Shandong Academy of Medical Sciences; the National Clinical Key Project of Dermatology and Venereology;the Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University;the Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University; the Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University);the National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College. Supported by the Science and Technology Planning Project of Guangdong Province,China (2016A020216013),the Guangdong Natural Science Funds for Distinguished Young Scholar (Grant No.2014A030306039), the Municipal Healthcare Joint-Innovation Major Project of Guangzhou and High-level personnel of special support program for Technology Innovative Talents and the Top Young of Guangdong Province (Grant No.2015TQ01R516),the National Supercomputer Center in Guangzhou and the Agency of Science, Technology and Research (A*STAR) of Singapore, the HUJ-CREATE Programme of the National Research Foundation, Singapore (Project Number 370062002), the U.S. National Institutes of Health (Grant Numbers R01CA144034 and UM1 CA182876), the Singapore National Medical Research Council(Grant Number 1270/2010), the 5010 Project of Sun Yat-sen University(Grant No.2007023), Distinguished Young Scholar Candidates Programme for The Third Affiliated Hospital of Sun Yat-Sen University and Pearl River Nova Program of Guangzhou (Grant No. 201610010005). Address Correspondence to Prof. J Gu, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen Universiy, Guangzhou 510630, China; Email:gujieruo@163.com or Prof. J. Liu, Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138672; Email: liuj3@gis.a-star.edu.sg
Jun Qi
From the Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen Universiy; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR);the Jackson Laboratory,USA; the Singapore Eye Research Institute (SERI);the Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), the Health Systems and Services Research, Duke-NUS Medical School; the department of Ophthalmology, the department of Paediatrics,Yong Loo Lin School of Medicine;the Khoo Teck Puat - National University Children's Medical Institute; the Saw Swee Hock School of Public Health, National University of Singapore; the division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, the department of Epidemiology, Graduate School of Public Health, University of Pittsburgh; the State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center;the Shandong Provincial Institute of Dermatology and Venereology & Hospital for Skin Diseases, Shandong First Medical University & Shandong Academy of Medical Sciences; the National Clinical Key Project of Dermatology and Venereology;the Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University;the Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University; the Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University);the National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College. Supported by the Science and Technology Planning Project of Guangdong Province,China (2016A020216013),the Guangdong Natural Science Funds for Distinguished Young Scholar (Grant No.2014A030306039), the Municipal Healthcare Joint-Innovation Major Project of Guangzhou and High-level personnel of special support program for Technology Innovative Talents and the Top Young of Guangdong Province (Grant No.2015TQ01R516),the National Supercomputer Center in Guangzhou and the Agency of Science, Technology and Research (A*STAR) of Singapore, the HUJ-CREATE Programme of the National Research Foundation, Singapore (Project Number 370062002), the U.S. National Institutes of Health (Grant Numbers R01CA144034 and UM1 CA182876), the Singapore National Medical Research Council(Grant Number 1270/2010), the 5010 Project of Sun Yat-sen University(Grant No.2007023), Distinguished Young Scholar Candidates Programme for The Third Affiliated Hospital of Sun Yat-Sen University and Pearl River Nova Program of Guangzhou (Grant No. 201610010005). Address Correspondence to Prof. J Gu, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen Universiy, Guangzhou 510630, China; Email:gujieruo@163.com or Prof. J. Liu, Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138672; Email: liuj3@gis.a-star.edu.sg
Qing Lv
From the Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen Universiy; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR);the Jackson Laboratory,USA; the Singapore Eye Research Institute (SERI);the Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), the Health Systems and Services Research, Duke-NUS Medical School; the department of Ophthalmology, the department of Paediatrics,Yong Loo Lin School of Medicine;the Khoo Teck Puat - National University Children's Medical Institute; the Saw Swee Hock School of Public Health, National University of Singapore; the division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, the department of Epidemiology, Graduate School of Public Health, University of Pittsburgh; the State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center;the Shandong Provincial Institute of Dermatology and Venereology & Hospital for Skin Diseases, Shandong First Medical University & Shandong Academy of Medical Sciences; the National Clinical Key Project of Dermatology and Venereology;the Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University;the Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University; the Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University);the National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College. Supported by the Science and Technology Planning Project of Guangdong Province,China (2016A020216013),the Guangdong Natural Science Funds for Distinguished Young Scholar (Grant No.2014A030306039), the Municipal Healthcare Joint-Innovation Major Project of Guangzhou and High-level personnel of special support program for Technology Innovative Talents and the Top Young of Guangdong Province (Grant No.2015TQ01R516),the National Supercomputer Center in Guangzhou and the Agency of Science, Technology and Research (A*STAR) of Singapore, the HUJ-CREATE Programme of the National Research Foundation, Singapore (Project Number 370062002), the U.S. National Institutes of Health (Grant Numbers R01CA144034 and UM1 CA182876), the Singapore National Medical Research Council(Grant Number 1270/2010), the 5010 Project of Sun Yat-sen University(Grant No.2007023), Distinguished Young Scholar Candidates Programme for The Third Affiliated Hospital of Sun Yat-Sen University and Pearl River Nova Program of Guangzhou (Grant No. 201610010005). Address Correspondence to Prof. J Gu, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen Universiy, Guangzhou 510630, China; Email:gujieruo@163.com or Prof. J. Liu, Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138672; Email: liuj3@gis.a-star.edu.sg
Ling Wang
From the Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen Universiy; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR);the Jackson Laboratory,USA; the Singapore Eye Research Institute (SERI);the Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), the Health Systems and Services Research, Duke-NUS Medical School; the department of Ophthalmology, the department of Paediatrics,Yong Loo Lin School of Medicine;the Khoo Teck Puat - National University Children's Medical Institute; the Saw Swee Hock School of Public Health, National University of Singapore; the division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, the department of Epidemiology, Graduate School of Public Health, University of Pittsburgh; the State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center;the Shandong Provincial Institute of Dermatology and Venereology & Hospital for Skin Diseases, Shandong First Medical University & Shandong Academy of Medical Sciences; the National Clinical Key Project of Dermatology and Venereology;the Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University;the Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University; the Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University);the National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College. Supported by the Science and Technology Planning Project of Guangdong Province,China (2016A020216013),the Guangdong Natural Science Funds for Distinguished Young Scholar (Grant No.2014A030306039), the Municipal Healthcare Joint-Innovation Major Project of Guangzhou and High-level personnel of special support program for Technology Innovative Talents and the Top Young of Guangdong Province (Grant No.2015TQ01R516),the National Supercomputer Center in Guangzhou and the Agency of Science, Technology and Research (A*STAR) of Singapore, the HUJ-CREATE Programme of the National Research Foundation, Singapore (Project Number 370062002), the U.S. National Institutes of Health (Grant Numbers R01CA144034 and UM1 CA182876), the Singapore National Medical Research Council(Grant Number 1270/2010), the 5010 Project of Sun Yat-sen University(Grant No.2007023), Distinguished Young Scholar Candidates Programme for The Third Affiliated Hospital of Sun Yat-Sen University and Pearl River Nova Program of Guangzhou (Grant No. 201610010005). Address Correspondence to Prof. J Gu, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen Universiy, Guangzhou 510630, China; Email:gujieruo@163.com or Prof. J. Liu, Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138672; Email: liuj3@gis.a-star.edu.sg
Yi Li
From the Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen Universiy; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR);the Jackson Laboratory,USA; the Singapore Eye Research Institute (SERI);the Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), the Health Systems and Services Research, Duke-NUS Medical School; the department of Ophthalmology, the department of Paediatrics,Yong Loo Lin School of Medicine;the Khoo Teck Puat - National University Children's Medical Institute; the Saw Swee Hock School of Public Health, National University of Singapore; the division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, the department of Epidemiology, Graduate School of Public Health, University of Pittsburgh; the State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center;the Shandong Provincial Institute of Dermatology and Venereology & Hospital for Skin Diseases, Shandong First Medical University & Shandong Academy of Medical Sciences; the National Clinical Key Project of Dermatology and Venereology;the Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University;the Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University; the Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University);the National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College. Supported by the Science and Technology Planning Project of Guangdong Province,China (2016A020216013),the Guangdong Natural Science Funds for Distinguished Young Scholar (Grant No.2014A030306039), the Municipal Healthcare Joint-Innovation Major Project of Guangzhou and High-level personnel of special support program for Technology Innovative Talents and the Top Young of Guangdong Province (Grant No.2015TQ01R516),the National Supercomputer Center in Guangzhou and the Agency of Science, Technology and Research (A*STAR) of Singapore, the HUJ-CREATE Programme of the National Research Foundation, Singapore (Project Number 370062002), the U.S. National Institutes of Health (Grant Numbers R01CA144034 and UM1 CA182876), the Singapore National Medical Research Council(Grant Number 1270/2010), the 5010 Project of Sun Yat-sen University(Grant No.2007023), Distinguished Young Scholar Candidates Programme for The Third Affiliated Hospital of Sun Yat-Sen University and Pearl River Nova Program of Guangzhou (Grant No. 201610010005). Address Correspondence to Prof. J Gu, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen Universiy, Guangzhou 510630, China; Email:gujieruo@163.com or Prof. J. Liu, Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138672; Email: liuj3@gis.a-star.edu.sg
Astrid Irwanto
From the Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen Universiy; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR);the Jackson Laboratory,USA; the Singapore Eye Research Institute (SERI);the Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), the Health Systems and Services Research, Duke-NUS Medical School; the department of Ophthalmology, the department of Paediatrics,Yong Loo Lin School of Medicine;the Khoo Teck Puat - National University Children's Medical Institute; the Saw Swee Hock School of Public Health, National University of Singapore; the division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, the department of Epidemiology, Graduate School of Public Health, University of Pittsburgh; the State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center;the Shandong Provincial Institute of Dermatology and Venereology & Hospital for Skin Diseases, Shandong First Medical University & Shandong Academy of Medical Sciences; the National Clinical Key Project of Dermatology and Venereology;the Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University;the Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University; the Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University);the National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College. Supported by the Science and Technology Planning Project of Guangdong Province,China (2016A020216013),the Guangdong Natural Science Funds for Distinguished Young Scholar (Grant No.2014A030306039), the Municipal Healthcare Joint-Innovation Major Project of Guangzhou and High-level personnel of special support program for Technology Innovative Talents and the Top Young of Guangdong Province (Grant No.2015TQ01R516),the National Supercomputer Center in Guangzhou and the Agency of Science, Technology and Research (A*STAR) of Singapore, the HUJ-CREATE Programme of the National Research Foundation, Singapore (Project Number 370062002), the U.S. National Institutes of Health (Grant Numbers R01CA144034 and UM1 CA182876), the Singapore National Medical Research Council(Grant Number 1270/2010), the 5010 Project of Sun Yat-sen University(Grant No.2007023), Distinguished Young Scholar Candidates Programme for The Third Affiliated Hospital of Sun Yat-Sen University and Pearl River Nova Program of Guangzhou (Grant No. 201610010005). Address Correspondence to Prof. J Gu, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen Universiy, Guangzhou 510630, China; Email:gujieruo@163.com or Prof. J. Liu, Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138672; Email: liuj3@gis.a-star.edu.sg
Ching-Yu Cheng
From the Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen Universiy; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR);the Jackson Laboratory,USA; the Singapore Eye Research Institute (SERI);the Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), the Health Systems and Services Research, Duke-NUS Medical School; the department of Ophthalmology, the department of Paediatrics,Yong Loo Lin School of Medicine;the Khoo Teck Puat - National University Children's Medical Institute; the Saw Swee Hock School of Public Health, National University of Singapore; the division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, the department of Epidemiology, Graduate School of Public Health, University of Pittsburgh; the State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center;the Shandong Provincial Institute of Dermatology and Venereology & Hospital for Skin Diseases, Shandong First Medical University & Shandong Academy of Medical Sciences; the National Clinical Key Project of Dermatology and Venereology;the Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University;the Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University; the Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University);the National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College. Supported by the Science and Technology Planning Project of Guangdong Province,China (2016A020216013),the Guangdong Natural Science Funds for Distinguished Young Scholar (Grant No.2014A030306039), the Municipal Healthcare Joint-Innovation Major Project of Guangzhou and High-level personnel of special support program for Technology Innovative Talents and the Top Young of Guangdong Province (Grant No.2015TQ01R516),the National Supercomputer Center in Guangzhou and the Agency of Science, Technology and Research (A*STAR) of Singapore, the HUJ-CREATE Programme of the National Research Foundation, Singapore (Project Number 370062002), the U.S. National Institutes of Health (Grant Numbers R01CA144034 and UM1 CA182876), the Singapore National Medical Research Council(Grant Number 1270/2010), the 5010 Project of Sun Yat-sen University(Grant No.2007023), Distinguished Young Scholar Candidates Programme for The Third Affiliated Hospital of Sun Yat-Sen University and Pearl River Nova Program of Guangzhou (Grant No. 201610010005). Address Correspondence to Prof. J Gu, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen Universiy, Guangzhou 510630, China; Email:gujieruo@163.com or Prof. J. Liu, Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138672; Email: liuj3@gis.a-star.edu.sg
Xiaoran Chai
From the Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen Universiy; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR);the Jackson Laboratory,USA; the Singapore Eye Research Institute (SERI);the Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), the Health Systems and Services Research, Duke-NUS Medical School; the department of Ophthalmology, the department of Paediatrics,Yong Loo Lin School of Medicine;the Khoo Teck Puat - National University Children's Medical Institute; the Saw Swee Hock School of Public Health, National University of Singapore; the division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, the department of Epidemiology, Graduate School of Public Health, University of Pittsburgh; the State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center;the Shandong Provincial Institute of Dermatology and Venereology & Hospital for Skin Diseases, Shandong First Medical University & Shandong Academy of Medical Sciences; the National Clinical Key Project of Dermatology and Venereology;the Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University;the Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University; the Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University);the National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College. Supported by the Science and Technology Planning Project of Guangdong Province,China (2016A020216013),the Guangdong Natural Science Funds for Distinguished Young Scholar (Grant No.2014A030306039), the Municipal Healthcare Joint-Innovation Major Project of Guangzhou and High-level personnel of special support program for Technology Innovative Talents and the Top Young of Guangdong Province (Grant No.2015TQ01R516),the National Supercomputer Center in Guangzhou and the Agency of Science, Technology and Research (A*STAR) of Singapore, the HUJ-CREATE Programme of the National Research Foundation, Singapore (Project Number 370062002), the U.S. National Institutes of Health (Grant Numbers R01CA144034 and UM1 CA182876), the Singapore National Medical Research Council(Grant Number 1270/2010), the 5010 Project of Sun Yat-sen University(Grant No.2007023), Distinguished Young Scholar Candidates Programme for The Third Affiliated Hospital of Sun Yat-Sen University and Pearl River Nova Program of Guangzhou (Grant No. 201610010005). Address Correspondence to Prof. J Gu, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen Universiy, Guangzhou 510630, China; Email:gujieruo@163.com or Prof. J. Liu, Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138672; Email: liuj3@gis.a-star.edu.sg
Chiea Chuen Khor
From the Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen Universiy; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR);the Jackson Laboratory,USA; the Singapore Eye Research Institute (SERI);the Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), the Health Systems and Services Research, Duke-NUS Medical School; the department of Ophthalmology, the department of Paediatrics,Yong Loo Lin School of Medicine;the Khoo Teck Puat - National University Children's Medical Institute; the Saw Swee Hock School of Public Health, National University of Singapore; the division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, the department of Epidemiology, Graduate School of Public Health, University of Pittsburgh; the State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center;the Shandong Provincial Institute of Dermatology and Venereology & Hospital for Skin Diseases, Shandong First Medical University & Shandong Academy of Medical Sciences; the National Clinical Key Project of Dermatology and Venereology;the Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University;the Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University; the Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University);the National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College. Supported by the Science and Technology Planning Project of Guangdong Province,China (2016A020216013),the Guangdong Natural Science Funds for Distinguished Young Scholar (Grant No.2014A030306039), the Municipal Healthcare Joint-Innovation Major Project of Guangzhou and High-level personnel of special support program for Technology Innovative Talents and the Top Young of Guangdong Province (Grant No.2015TQ01R516),the National Supercomputer Center in Guangzhou and the Agency of Science, Technology and Research (A*STAR) of Singapore, the HUJ-CREATE Programme of the National Research Foundation, Singapore (Project Number 370062002), the U.S. National Institutes of Health (Grant Numbers R01CA144034 and UM1 CA182876), the Singapore National Medical Research Council(Grant Number 1270/2010), the 5010 Project of Sun Yat-sen University(Grant No.2007023), Distinguished Young Scholar Candidates Programme for The Third Affiliated Hospital of Sun Yat-Sen University and Pearl River Nova Program of Guangzhou (Grant No. 201610010005). Address Correspondence to Prof. J Gu, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen Universiy, Guangzhou 510630, China; Email:gujieruo@163.com or Prof. J. Liu, Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138672; Email: liuj3@gis.a-star.edu.sg
Chew-Kiat Heng
From the Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen Universiy; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR);the Jackson Laboratory,USA; the Singapore Eye Research Institute (SERI);the Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), the Health Systems and Services Research, Duke-NUS Medical School; the department of Ophthalmology, the department of Paediatrics,Yong Loo Lin School of Medicine;the Khoo Teck Puat - National University Children's Medical Institute; the Saw Swee Hock School of Public Health, National University of Singapore; the division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, the department of Epidemiology, Graduate School of Public Health, University of Pittsburgh; the State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center;the Shandong Provincial Institute of Dermatology and Venereology & Hospital for Skin Diseases, Shandong First Medical University & Shandong Academy of Medical Sciences; the National Clinical Key Project of Dermatology and Venereology;the Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University;the Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University; the Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University);the National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College. Supported by the Science and Technology Planning Project of Guangdong Province,China (2016A020216013),the Guangdong Natural Science Funds for Distinguished Young Scholar (Grant No.2014A030306039), the Municipal Healthcare Joint-Innovation Major Project of Guangzhou and High-level personnel of special support program for Technology Innovative Talents and the Top Young of Guangdong Province (Grant No.2015TQ01R516),the National Supercomputer Center in Guangzhou and the Agency of Science, Technology and Research (A*STAR) of Singapore, the HUJ-CREATE Programme of the National Research Foundation, Singapore (Project Number 370062002), the U.S. National Institutes of Health (Grant Numbers R01CA144034 and UM1 CA182876), the Singapore National Medical Research Council(Grant Number 1270/2010), the 5010 Project of Sun Yat-sen University(Grant No.2007023), Distinguished Young Scholar Candidates Programme for The Third Affiliated Hospital of Sun Yat-Sen University and Pearl River Nova Program of Guangzhou (Grant No. 201610010005). Address Correspondence to Prof. J Gu, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen Universiy, Guangzhou 510630, China; Email:gujieruo@163.com or Prof. J. Liu, Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138672; Email: liuj3@gis.a-star.edu.sg
Woon-Puay Koh
From the Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen Universiy; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR);the Jackson Laboratory,USA; the Singapore Eye Research Institute (SERI);the Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), the Health Systems and Services Research, Duke-NUS Medical School; the department of Ophthalmology, the department of Paediatrics,Yong Loo Lin School of Medicine;the Khoo Teck Puat - National University Children's Medical Institute; the Saw Swee Hock School of Public Health, National University of Singapore; the division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, the department of Epidemiology, Graduate School of Public Health, University of Pittsburgh; the State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center;the Shandong Provincial Institute of Dermatology and Venereology & Hospital for Skin Diseases, Shandong First Medical University & Shandong Academy of Medical Sciences; the National Clinical Key Project of Dermatology and Venereology;the Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University;the Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University; the Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University);the National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College. Supported by the Science and Technology Planning Project of Guangdong Province,China (2016A020216013),the Guangdong Natural Science Funds for Distinguished Young Scholar (Grant No.2014A030306039), the Municipal Healthcare Joint-Innovation Major Project of Guangzhou and High-level personnel of special support program for Technology Innovative Talents and the Top Young of Guangdong Province (Grant No.2015TQ01R516),the National Supercomputer Center in Guangzhou and the Agency of Science, Technology and Research (A*STAR) of Singapore, the HUJ-CREATE Programme of the National Research Foundation, Singapore (Project Number 370062002), the U.S. National Institutes of Health (Grant Numbers R01CA144034 and UM1 CA182876), the Singapore National Medical Research Council(Grant Number 1270/2010), the 5010 Project of Sun Yat-sen University(Grant No.2007023), Distinguished Young Scholar Candidates Programme for The Third Affiliated Hospital of Sun Yat-Sen University and Pearl River Nova Program of Guangzhou (Grant No. 201610010005). Address Correspondence to Prof. J Gu, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen Universiy, Guangzhou 510630, China; Email:gujieruo@163.com or Prof. J. Liu, Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138672; Email: liuj3@gis.a-star.edu.sg
Jian-Min Yuan
From the Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen Universiy; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR);the Jackson Laboratory,USA; the Singapore Eye Research Institute (SERI);the Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), the Health Systems and Services Research, Duke-NUS Medical School; the department of Ophthalmology, the department of Paediatrics,Yong Loo Lin School of Medicine;the Khoo Teck Puat - National University Children's Medical Institute; the Saw Swee Hock School of Public Health, National University of Singapore; the division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, the department of Epidemiology, Graduate School of Public Health, University of Pittsburgh; the State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center;the Shandong Provincial Institute of Dermatology and Venereology & Hospital for Skin Diseases, Shandong First Medical University & Shandong Academy of Medical Sciences; the National Clinical Key Project of Dermatology and Venereology;the Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University;the Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University; the Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University);the National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College. Supported by the Science and Technology Planning Project of Guangdong Province,China (2016A020216013),the Guangdong Natural Science Funds for Distinguished Young Scholar (Grant No.2014A030306039), the Municipal Healthcare Joint-Innovation Major Project of Guangzhou and High-level personnel of special support program for Technology Innovative Talents and the Top Young of Guangdong Province (Grant No.2015TQ01R516),the National Supercomputer Center in Guangzhou and the Agency of Science, Technology and Research (A*STAR) of Singapore, the HUJ-CREATE Programme of the National Research Foundation, Singapore (Project Number 370062002), the U.S. National Institutes of Health (Grant Numbers R01CA144034 and UM1 CA182876), the Singapore National Medical Research Council(Grant Number 1270/2010), the 5010 Project of Sun Yat-sen University(Grant No.2007023), Distinguished Young Scholar Candidates Programme for The Third Affiliated Hospital of Sun Yat-Sen University and Pearl River Nova Program of Guangzhou (Grant No. 201610010005). Address Correspondence to Prof. J Gu, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen Universiy, Guangzhou 510630, China; Email:gujieruo@163.com or Prof. J. Liu, Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138672; Email: liuj3@gis.a-star.edu.sg
Jinxin Bei
From the Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen Universiy; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR);the Jackson Laboratory,USA; the Singapore Eye Research Institute (SERI);the Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), the Health Systems and Services Research, Duke-NUS Medical School; the department of Ophthalmology, the department of Paediatrics,Yong Loo Lin School of Medicine;the Khoo Teck Puat - National University Children's Medical Institute; the Saw Swee Hock School of Public Health, National University of Singapore; the division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, the department of Epidemiology, Graduate School of Public Health, University of Pittsburgh; the State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center;the Shandong Provincial Institute of Dermatology and Venereology & Hospital for Skin Diseases, Shandong First Medical University & Shandong Academy of Medical Sciences; the National Clinical Key Project of Dermatology and Venereology;the Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University;the Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University; the Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University);the National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College. Supported by the Science and Technology Planning Project of Guangdong Province,China (2016A020216013),the Guangdong Natural Science Funds for Distinguished Young Scholar (Grant No.2014A030306039), the Municipal Healthcare Joint-Innovation Major Project of Guangzhou and High-level personnel of special support program for Technology Innovative Talents and the Top Young of Guangdong Province (Grant No.2015TQ01R516),the National Supercomputer Center in Guangzhou and the Agency of Science, Technology and Research (A*STAR) of Singapore, the HUJ-CREATE Programme of the National Research Foundation, Singapore (Project Number 370062002), the U.S. National Institutes of Health (Grant Numbers R01CA144034 and UM1 CA182876), the Singapore National Medical Research Council(Grant Number 1270/2010), the 5010 Project of Sun Yat-sen University(Grant No.2007023), Distinguished Young Scholar Candidates Programme for The Third Affiliated Hospital of Sun Yat-Sen University and Pearl River Nova Program of Guangzhou (Grant No. 201610010005). Address Correspondence to Prof. J Gu, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen Universiy, Guangzhou 510630, China; Email:gujieruo@163.com or Prof. J. Liu, Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138672; Email: liuj3@gis.a-star.edu.sg
Furen Zhang
From the Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen Universiy; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR);the Jackson Laboratory,USA; the Singapore Eye Research Institute (SERI);the Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), the Health Systems and Services Research, Duke-NUS Medical School; the department of Ophthalmology, the department of Paediatrics,Yong Loo Lin School of Medicine;the Khoo Teck Puat - National University Children's Medical Institute; the Saw Swee Hock School of Public Health, National University of Singapore; the division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, the department of Epidemiology, Graduate School of Public Health, University of Pittsburgh; the State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center;the Shandong Provincial Institute of Dermatology and Venereology & Hospital for Skin Diseases, Shandong First Medical University & Shandong Academy of Medical Sciences; the National Clinical Key Project of Dermatology and Venereology;the Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University;the Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University; the Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University);the National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College. Supported by the Science and Technology Planning Project of Guangdong Province,China (2016A020216013),the Guangdong Natural Science Funds for Distinguished Young Scholar (Grant No.2014A030306039), the Municipal Healthcare Joint-Innovation Major Project of Guangzhou and High-level personnel of special support program for Technology Innovative Talents and the Top Young of Guangdong Province (Grant No.2015TQ01R516),the National Supercomputer Center in Guangzhou and the Agency of Science, Technology and Research (A*STAR) of Singapore, the HUJ-CREATE Programme of the National Research Foundation, Singapore (Project Number 370062002), the U.S. National Institutes of Health (Grant Numbers R01CA144034 and UM1 CA182876), the Singapore National Medical Research Council(Grant Number 1270/2010), the 5010 Project of Sun Yat-sen University(Grant No.2007023), Distinguished Young Scholar Candidates Programme for The Third Affiliated Hospital of Sun Yat-Sen University and Pearl River Nova Program of Guangzhou (Grant No. 201610010005). Address Correspondence to Prof. J Gu, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen Universiy, Guangzhou 510630, China; Email:gujieruo@163.com or Prof. J. Liu, Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138672; Email: liuj3@gis.a-star.edu.sg
Xuejun Zhang
From the Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen Universiy; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR);the Jackson Laboratory,USA; the Singapore Eye Research Institute (SERI);the Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), the Health Systems and Services Research, Duke-NUS Medical School; the department of Ophthalmology, the department of Paediatrics,Yong Loo Lin School of Medicine;the Khoo Teck Puat - National University Children's Medical Institute; the Saw Swee Hock School of Public Health, National University of Singapore; the division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, the department of Epidemiology, Graduate School of Public Health, University of Pittsburgh; the State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center;the Shandong Provincial Institute of Dermatology and Venereology & Hospital for Skin Diseases, Shandong First Medical University & Shandong Academy of Medical Sciences; the National Clinical Key Project of Dermatology and Venereology;the Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University;the Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University; the Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University);the National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College. Supported by the Science and Technology Planning Project of Guangdong Province,China (2016A020216013),the Guangdong Natural Science Funds for Distinguished Young Scholar (Grant No.2014A030306039), the Municipal Healthcare Joint-Innovation Major Project of Guangzhou and High-level personnel of special support program for Technology Innovative Talents and the Top Young of Guangdong Province (Grant No.2015TQ01R516),the National Supercomputer Center in Guangzhou and the Agency of Science, Technology and Research (A*STAR) of Singapore, the HUJ-CREATE Programme of the National Research Foundation, Singapore (Project Number 370062002), the U.S. National Institutes of Health (Grant Numbers R01CA144034 and UM1 CA182876), the Singapore National Medical Research Council(Grant Number 1270/2010), the 5010 Project of Sun Yat-sen University(Grant No.2007023), Distinguished Young Scholar Candidates Programme for The Third Affiliated Hospital of Sun Yat-Sen University and Pearl River Nova Program of Guangzhou (Grant No. 201610010005). Address Correspondence to Prof. J Gu, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen Universiy, Guangzhou 510630, China; Email:gujieruo@163.com or Prof. J. Liu, Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138672; Email: liuj3@gis.a-star.edu.sg
Yixin Zeng
From the Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen Universiy; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR);the Jackson Laboratory,USA; the Singapore Eye Research Institute (SERI);the Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), the Health Systems and Services Research, Duke-NUS Medical School; the department of Ophthalmology, the department of Paediatrics,Yong Loo Lin School of Medicine;the Khoo Teck Puat - National University Children's Medical Institute; the Saw Swee Hock School of Public Health, National University of Singapore; the division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, the department of Epidemiology, Graduate School of Public Health, University of Pittsburgh; the State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center;the Shandong Provincial Institute of Dermatology and Venereology & Hospital for Skin Diseases, Shandong First Medical University & Shandong Academy of Medical Sciences; the National Clinical Key Project of Dermatology and Venereology;the Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University;the Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University; the Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University);the National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College. Supported by the Science and Technology Planning Project of Guangdong Province,China (2016A020216013),the Guangdong Natural Science Funds for Distinguished Young Scholar (Grant No.2014A030306039), the Municipal Healthcare Joint-Innovation Major Project of Guangzhou and High-level personnel of special support program for Technology Innovative Talents and the Top Young of Guangdong Province (Grant No.2015TQ01R516),the National Supercomputer Center in Guangzhou and the Agency of Science, Technology and Research (A*STAR) of Singapore, the HUJ-CREATE Programme of the National Research Foundation, Singapore (Project Number 370062002), the U.S. National Institutes of Health (Grant Numbers R01CA144034 and UM1 CA182876), the Singapore National Medical Research Council(Grant Number 1270/2010), the 5010 Project of Sun Yat-sen University(Grant No.2007023), Distinguished Young Scholar Candidates Programme for The Third Affiliated Hospital of Sun Yat-Sen University and Pearl River Nova Program of Guangzhou (Grant No. 201610010005). Address Correspondence to Prof. J Gu, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen Universiy, Guangzhou 510630, China; Email:gujieruo@163.com or Prof. J. Liu, Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138672; Email: liuj3@gis.a-star.edu.sg
Yan Shen
From the Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen Universiy; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR);the Jackson Laboratory,USA; the Singapore Eye Research Institute (SERI);the Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), the Health Systems and Services Research, Duke-NUS Medical School; the department of Ophthalmology, the department of Paediatrics,Yong Loo Lin School of Medicine;the Khoo Teck Puat - National University Children's Medical Institute; the Saw Swee Hock School of Public Health, National University of Singapore; the division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, the department of Epidemiology, Graduate School of Public Health, University of Pittsburgh; the State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center;the Shandong Provincial Institute of Dermatology and Venereology & Hospital for Skin Diseases, Shandong First Medical University & Shandong Academy of Medical Sciences; the National Clinical Key Project of Dermatology and Venereology;the Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University;the Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University; the Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University);the National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College. Supported by the Science and Technology Planning Project of Guangdong Province,China (2016A020216013),the Guangdong Natural Science Funds for Distinguished Young Scholar (Grant No.2014A030306039), the Municipal Healthcare Joint-Innovation Major Project of Guangzhou and High-level personnel of special support program for Technology Innovative Talents and the Top Young of Guangdong Province (Grant No.2015TQ01R516),the National Supercomputer Center in Guangzhou and the Agency of Science, Technology and Research (A*STAR) of Singapore, the HUJ-CREATE Programme of the National Research Foundation, Singapore (Project Number 370062002), the U.S. National Institutes of Health (Grant Numbers R01CA144034 and UM1 CA182876), the Singapore National Medical Research Council(Grant Number 1270/2010), the 5010 Project of Sun Yat-sen University(Grant No.2007023), Distinguished Young Scholar Candidates Programme for The Third Affiliated Hospital of Sun Yat-Sen University and Pearl River Nova Program of Guangzhou (Grant No. 201610010005). Address Correspondence to Prof. J Gu, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen Universiy, Guangzhou 510630, China; Email:gujieruo@163.com or Prof. J. Liu, Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138672; Email: liuj3@gis.a-star.edu.sg
Jianjun Liu
From the Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen Universiy; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR);the Jackson Laboratory,USA; the Singapore Eye Research Institute (SERI);the Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), the Health Systems and Services Research, Duke-NUS Medical School; the department of Ophthalmology, the department of Paediatrics,Yong Loo Lin School of Medicine;the Khoo Teck Puat - National University Children's Medical Institute; the Saw Swee Hock School of Public Health, National University of Singapore; the division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, the department of Epidemiology, Graduate School of Public Health, University of Pittsburgh; the State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center;the Shandong Provincial Institute of Dermatology and Venereology & Hospital for Skin Diseases, Shandong First Medical University & Shandong Academy of Medical Sciences; the National Clinical Key Project of Dermatology and Venereology;the Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University;the Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University; the Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University);the National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College. Supported by the Science and Technology Planning Project of Guangdong Province,China (2016A020216013),the Guangdong Natural Science Funds for Distinguished Young Scholar (Grant No.2014A030306039), the Municipal Healthcare Joint-Innovation Major Project of Guangzhou and High-level personnel of special support program for Technology Innovative Talents and the Top Young of Guangdong Province (Grant No.2015TQ01R516),the National Supercomputer Center in Guangzhou and the Agency of Science, Technology and Research (A*STAR) of Singapore, the HUJ-CREATE Programme of the National Research Foundation, Singapore (Project Number 370062002), the U.S. National Institutes of Health (Grant Numbers R01CA144034 and UM1 CA182876), the Singapore National Medical Research Council(Grant Number 1270/2010), the 5010 Project of Sun Yat-sen University(Grant No.2007023), Distinguished Young Scholar Candidates Programme for The Third Affiliated Hospital of Sun Yat-Sen University and Pearl River Nova Program of Guangzhou (Grant No. 201610010005). Address Correspondence to Prof. J Gu, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen Universiy, Guangzhou 510630, China; Email:gujieruo@163.com or Prof. J. Liu, Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138672; Email: liuj3@gis.a-star.edu.sg
Jieruo Gu
From the Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen Universiy; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR);the Jackson Laboratory,USA; the Singapore Eye Research Institute (SERI);the Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), the Health Systems and Services Research, Duke-NUS Medical School; the department of Ophthalmology, the department of Paediatrics,Yong Loo Lin School of Medicine;the Khoo Teck Puat - National University Children's Medical Institute; the Saw Swee Hock School of Public Health, National University of Singapore; the division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, the department of Epidemiology, Graduate School of Public Health, University of Pittsburgh; the State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center;the Shandong Provincial Institute of Dermatology and Venereology & Hospital for Skin Diseases, Shandong First Medical University & Shandong Academy of Medical Sciences; the National Clinical Key Project of Dermatology and Venereology;the Institute of Dermatology and Department of Dermatology, Huashan Hospital of Fudan University;the Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University; the Key Laboratory of Dermatology, Ministry of Education (Anhui Medical University);the National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College. Supported by the Science and Technology Planning Project of Guangdong Province,China (2016A020216013),the Guangdong Natural Science Funds for Distinguished Young Scholar (Grant No.2014A030306039), the Municipal Healthcare Joint-Innovation Major Project of Guangzhou and High-level personnel of special support program for Technology Innovative Talents and the Top Young of Guangdong Province (Grant No.2015TQ01R516),the National Supercomputer Center in Guangzhou and the Agency of Science, Technology and Research (A*STAR) of Singapore, the HUJ-CREATE Programme of the National Research Foundation, Singapore (Project Number 370062002), the U.S. National Institutes of Health (Grant Numbers R01CA144034 and UM1 CA182876), the Singapore National Medical Research Council(Grant Number 1270/2010), the 5010 Project of Sun Yat-sen University(Grant No.2007023), Distinguished Young Scholar Candidates Programme for The Third Affiliated Hospital of Sun Yat-Sen University and Pearl River Nova Program of Guangzhou (Grant No. 201610010005). Address Correspondence to Prof. J Gu, Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen Universiy, Guangzhou 510630, China; Email:gujieruo@163.com or Prof. J. Liu, Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138672; Email: liuj3@gis.a-star.edu.sg
Data supplements
Data Supplement
In this issue
The Journal of Rheumatology
Vol. 51, Issue 3
1 Mar 2024
Accepted manuscript
Analysis of 47 non-MHC Ankylosing Spondylitis Susceptibility Loci Reveals Shared Associated Variants across Caucasians and Han Chinese
Xuqi Zheng, Qiuxia Li, Xiaomin Li, Yanli Zhang, Xinyu Wu, Qiujing Wei, Shuangyan Cao, Mingcan Yang, Zhiming Lin, Zetao Liao, Jun Qi, Qing Lv, Ling Wang, Yi Li, Astrid Irwanto, Ching-Yu Cheng, Xiaoran Chai, Chiea Chuen Khor, Chew-Kiat Heng, Woon-Puay Koh, Jian-Min Yuan, Jinxin Bei, Furen Zhang, Xuejun Zhang, Yixin Zeng, Yan Shen, Jianjun Liu, Jieruo Gu
The Journal of Rheumatology Sep 2019, jrheum.190184; DOI: 10.3899/jrheum.190184
Accepted manuscript
Analysis of 47 non-MHC Ankylosing Spondylitis Susceptibility Loci Reveals Shared Associated Variants across Caucasians and Han Chinese
Xuqi Zheng, Qiuxia Li, Xiaomin Li, Yanli Zhang, Xinyu Wu, Qiujing Wei, Shuangyan Cao, Mingcan Yang, Zhiming Lin, Zetao Liao, Jun Qi, Qing Lv, Ling Wang, Yi Li, Astrid Irwanto, Ching-Yu Cheng, Xiaoran Chai, Chiea Chuen Khor, Chew-Kiat Heng, Woon-Puay Koh, Jian-Min Yuan, Jinxin Bei, Furen Zhang, Xuejun Zhang, Yixin Zeng, Yan Shen, Jianjun Liu, Jieruo Gu
The Journal of Rheumatology Sep 2019, jrheum.190184; DOI: 10.3899/jrheum.190184