Research ArticleArticle
Development and Validation of a MicroRNA Panel to Differentiate Between Patients with Rheumatoid Arthritis or Systemic Lupus Erythematosus and Controls
Michelle J. Ormseth, Joseph F. Solus, Quanhu Sheng, Fei Ye, Qiong Wu, Yan Guo, Annette M. Oeser, Ryan M. Allen, Kasey C. Vickers and C. Michael Stein
The Journal of Rheumatology May 2019, jrheum.181029; DOI: https://doi.org/10.3899/jrheum.181029
Michelle J. Ormseth
From the Tennessee Valley Healthcare System, US Department of Veterans Affairs; Department of Medicine, Vanderbilt University Medical Center; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee; Department of Bioinformatics, University of New Mexico, Albuquerque, New Mexico, USA. Funded by the Veterans Health Administration CDA IK2CX001269, Arthritis Foundation Delivering on Discovery grant, Alpha Omicron Pi, US National Institutes of Health grants P60 AR056116, P01 HL116263, and CTSA award UL1TR000445 from the National Center for Advancing Translational Sciences. M.J. Ormseth, MD, Tennessee Valley Healthcare System, US Department of Veterans Affairs, and Department of Medicine, Vanderbilt University Medical Center; J.F. Solus, PhD, Department of Medicine, Vanderbilt University Medical Center; Q. Sheng, PhD, Department of Biostatistics, Vanderbilt University Medical Center; F. Ye, PhD, Department of Biostatistics, Vanderbilt University Medical Center; Q. Wu, PhD, Department of Medicine, Vanderbilt University Medical Center; Y. Guo, PhD, Department of Bioinformatics, University of New Mexico; A.M. Oeser, BA, MLAS, CCRP, Department of Medicine, Vanderbilt University Medical Center; R.M. Allen, PhD, Department of Medicine, Vanderbilt University Medical Center; K.C. Vickers, PhD, Department of Medicine, Vanderbilt University Medical Center; C.M. Stein, MBChB, Department of Medicine, Vanderbilt University Medical Center. Address correspondence to Dr. M.J. Ormseth, 1161 21st Ave. South, T-3113 MCN, Nashville, Tennessee 37232-2681, USA. E-mail: michelle.ormseth@vumc.org. Accepted for publication May 1, 2019.
Joseph F. Solus
From the Tennessee Valley Healthcare System, US Department of Veterans Affairs; Department of Medicine, Vanderbilt University Medical Center; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee; Department of Bioinformatics, University of New Mexico, Albuquerque, New Mexico, USA. Funded by the Veterans Health Administration CDA IK2CX001269, Arthritis Foundation Delivering on Discovery grant, Alpha Omicron Pi, US National Institutes of Health grants P60 AR056116, P01 HL116263, and CTSA award UL1TR000445 from the National Center for Advancing Translational Sciences. M.J. Ormseth, MD, Tennessee Valley Healthcare System, US Department of Veterans Affairs, and Department of Medicine, Vanderbilt University Medical Center; J.F. Solus, PhD, Department of Medicine, Vanderbilt University Medical Center; Q. Sheng, PhD, Department of Biostatistics, Vanderbilt University Medical Center; F. Ye, PhD, Department of Biostatistics, Vanderbilt University Medical Center; Q. Wu, PhD, Department of Medicine, Vanderbilt University Medical Center; Y. Guo, PhD, Department of Bioinformatics, University of New Mexico; A.M. Oeser, BA, MLAS, CCRP, Department of Medicine, Vanderbilt University Medical Center; R.M. Allen, PhD, Department of Medicine, Vanderbilt University Medical Center; K.C. Vickers, PhD, Department of Medicine, Vanderbilt University Medical Center; C.M. Stein, MBChB, Department of Medicine, Vanderbilt University Medical Center. Address correspondence to Dr. M.J. Ormseth, 1161 21st Ave. South, T-3113 MCN, Nashville, Tennessee 37232-2681, USA. E-mail: michelle.ormseth@vumc.org. Accepted for publication May 1, 2019.
Quanhu Sheng
From the Tennessee Valley Healthcare System, US Department of Veterans Affairs; Department of Medicine, Vanderbilt University Medical Center; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee; Department of Bioinformatics, University of New Mexico, Albuquerque, New Mexico, USA. Funded by the Veterans Health Administration CDA IK2CX001269, Arthritis Foundation Delivering on Discovery grant, Alpha Omicron Pi, US National Institutes of Health grants P60 AR056116, P01 HL116263, and CTSA award UL1TR000445 from the National Center for Advancing Translational Sciences. M.J. Ormseth, MD, Tennessee Valley Healthcare System, US Department of Veterans Affairs, and Department of Medicine, Vanderbilt University Medical Center; J.F. Solus, PhD, Department of Medicine, Vanderbilt University Medical Center; Q. Sheng, PhD, Department of Biostatistics, Vanderbilt University Medical Center; F. Ye, PhD, Department of Biostatistics, Vanderbilt University Medical Center; Q. Wu, PhD, Department of Medicine, Vanderbilt University Medical Center; Y. Guo, PhD, Department of Bioinformatics, University of New Mexico; A.M. Oeser, BA, MLAS, CCRP, Department of Medicine, Vanderbilt University Medical Center; R.M. Allen, PhD, Department of Medicine, Vanderbilt University Medical Center; K.C. Vickers, PhD, Department of Medicine, Vanderbilt University Medical Center; C.M. Stein, MBChB, Department of Medicine, Vanderbilt University Medical Center. Address correspondence to Dr. M.J. Ormseth, 1161 21st Ave. South, T-3113 MCN, Nashville, Tennessee 37232-2681, USA. E-mail: michelle.ormseth@vumc.org. Accepted for publication May 1, 2019.
Fei Ye
From the Tennessee Valley Healthcare System, US Department of Veterans Affairs; Department of Medicine, Vanderbilt University Medical Center; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee; Department of Bioinformatics, University of New Mexico, Albuquerque, New Mexico, USA. Funded by the Veterans Health Administration CDA IK2CX001269, Arthritis Foundation Delivering on Discovery grant, Alpha Omicron Pi, US National Institutes of Health grants P60 AR056116, P01 HL116263, and CTSA award UL1TR000445 from the National Center for Advancing Translational Sciences. M.J. Ormseth, MD, Tennessee Valley Healthcare System, US Department of Veterans Affairs, and Department of Medicine, Vanderbilt University Medical Center; J.F. Solus, PhD, Department of Medicine, Vanderbilt University Medical Center; Q. Sheng, PhD, Department of Biostatistics, Vanderbilt University Medical Center; F. Ye, PhD, Department of Biostatistics, Vanderbilt University Medical Center; Q. Wu, PhD, Department of Medicine, Vanderbilt University Medical Center; Y. Guo, PhD, Department of Bioinformatics, University of New Mexico; A.M. Oeser, BA, MLAS, CCRP, Department of Medicine, Vanderbilt University Medical Center; R.M. Allen, PhD, Department of Medicine, Vanderbilt University Medical Center; K.C. Vickers, PhD, Department of Medicine, Vanderbilt University Medical Center; C.M. Stein, MBChB, Department of Medicine, Vanderbilt University Medical Center. Address correspondence to Dr. M.J. Ormseth, 1161 21st Ave. South, T-3113 MCN, Nashville, Tennessee 37232-2681, USA. E-mail: michelle.ormseth@vumc.org. Accepted for publication May 1, 2019.
Qiong Wu
From the Tennessee Valley Healthcare System, US Department of Veterans Affairs; Department of Medicine, Vanderbilt University Medical Center; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee; Department of Bioinformatics, University of New Mexico, Albuquerque, New Mexico, USA. Funded by the Veterans Health Administration CDA IK2CX001269, Arthritis Foundation Delivering on Discovery grant, Alpha Omicron Pi, US National Institutes of Health grants P60 AR056116, P01 HL116263, and CTSA award UL1TR000445 from the National Center for Advancing Translational Sciences. M.J. Ormseth, MD, Tennessee Valley Healthcare System, US Department of Veterans Affairs, and Department of Medicine, Vanderbilt University Medical Center; J.F. Solus, PhD, Department of Medicine, Vanderbilt University Medical Center; Q. Sheng, PhD, Department of Biostatistics, Vanderbilt University Medical Center; F. Ye, PhD, Department of Biostatistics, Vanderbilt University Medical Center; Q. Wu, PhD, Department of Medicine, Vanderbilt University Medical Center; Y. Guo, PhD, Department of Bioinformatics, University of New Mexico; A.M. Oeser, BA, MLAS, CCRP, Department of Medicine, Vanderbilt University Medical Center; R.M. Allen, PhD, Department of Medicine, Vanderbilt University Medical Center; K.C. Vickers, PhD, Department of Medicine, Vanderbilt University Medical Center; C.M. Stein, MBChB, Department of Medicine, Vanderbilt University Medical Center. Address correspondence to Dr. M.J. Ormseth, 1161 21st Ave. South, T-3113 MCN, Nashville, Tennessee 37232-2681, USA. E-mail: michelle.ormseth@vumc.org. Accepted for publication May 1, 2019.
Yan Guo
From the Tennessee Valley Healthcare System, US Department of Veterans Affairs; Department of Medicine, Vanderbilt University Medical Center; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee; Department of Bioinformatics, University of New Mexico, Albuquerque, New Mexico, USA. Funded by the Veterans Health Administration CDA IK2CX001269, Arthritis Foundation Delivering on Discovery grant, Alpha Omicron Pi, US National Institutes of Health grants P60 AR056116, P01 HL116263, and CTSA award UL1TR000445 from the National Center for Advancing Translational Sciences. M.J. Ormseth, MD, Tennessee Valley Healthcare System, US Department of Veterans Affairs, and Department of Medicine, Vanderbilt University Medical Center; J.F. Solus, PhD, Department of Medicine, Vanderbilt University Medical Center; Q. Sheng, PhD, Department of Biostatistics, Vanderbilt University Medical Center; F. Ye, PhD, Department of Biostatistics, Vanderbilt University Medical Center; Q. Wu, PhD, Department of Medicine, Vanderbilt University Medical Center; Y. Guo, PhD, Department of Bioinformatics, University of New Mexico; A.M. Oeser, BA, MLAS, CCRP, Department of Medicine, Vanderbilt University Medical Center; R.M. Allen, PhD, Department of Medicine, Vanderbilt University Medical Center; K.C. Vickers, PhD, Department of Medicine, Vanderbilt University Medical Center; C.M. Stein, MBChB, Department of Medicine, Vanderbilt University Medical Center. Address correspondence to Dr. M.J. Ormseth, 1161 21st Ave. South, T-3113 MCN, Nashville, Tennessee 37232-2681, USA. E-mail: michelle.ormseth@vumc.org. Accepted for publication May 1, 2019.
Annette M. Oeser
From the Tennessee Valley Healthcare System, US Department of Veterans Affairs; Department of Medicine, Vanderbilt University Medical Center; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee; Department of Bioinformatics, University of New Mexico, Albuquerque, New Mexico, USA. Funded by the Veterans Health Administration CDA IK2CX001269, Arthritis Foundation Delivering on Discovery grant, Alpha Omicron Pi, US National Institutes of Health grants P60 AR056116, P01 HL116263, and CTSA award UL1TR000445 from the National Center for Advancing Translational Sciences. M.J. Ormseth, MD, Tennessee Valley Healthcare System, US Department of Veterans Affairs, and Department of Medicine, Vanderbilt University Medical Center; J.F. Solus, PhD, Department of Medicine, Vanderbilt University Medical Center; Q. Sheng, PhD, Department of Biostatistics, Vanderbilt University Medical Center; F. Ye, PhD, Department of Biostatistics, Vanderbilt University Medical Center; Q. Wu, PhD, Department of Medicine, Vanderbilt University Medical Center; Y. Guo, PhD, Department of Bioinformatics, University of New Mexico; A.M. Oeser, BA, MLAS, CCRP, Department of Medicine, Vanderbilt University Medical Center; R.M. Allen, PhD, Department of Medicine, Vanderbilt University Medical Center; K.C. Vickers, PhD, Department of Medicine, Vanderbilt University Medical Center; C.M. Stein, MBChB, Department of Medicine, Vanderbilt University Medical Center. Address correspondence to Dr. M.J. Ormseth, 1161 21st Ave. South, T-3113 MCN, Nashville, Tennessee 37232-2681, USA. E-mail: michelle.ormseth@vumc.org. Accepted for publication May 1, 2019.
Ryan M. Allen
From the Tennessee Valley Healthcare System, US Department of Veterans Affairs; Department of Medicine, Vanderbilt University Medical Center; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee; Department of Bioinformatics, University of New Mexico, Albuquerque, New Mexico, USA. Funded by the Veterans Health Administration CDA IK2CX001269, Arthritis Foundation Delivering on Discovery grant, Alpha Omicron Pi, US National Institutes of Health grants P60 AR056116, P01 HL116263, and CTSA award UL1TR000445 from the National Center for Advancing Translational Sciences. M.J. Ormseth, MD, Tennessee Valley Healthcare System, US Department of Veterans Affairs, and Department of Medicine, Vanderbilt University Medical Center; J.F. Solus, PhD, Department of Medicine, Vanderbilt University Medical Center; Q. Sheng, PhD, Department of Biostatistics, Vanderbilt University Medical Center; F. Ye, PhD, Department of Biostatistics, Vanderbilt University Medical Center; Q. Wu, PhD, Department of Medicine, Vanderbilt University Medical Center; Y. Guo, PhD, Department of Bioinformatics, University of New Mexico; A.M. Oeser, BA, MLAS, CCRP, Department of Medicine, Vanderbilt University Medical Center; R.M. Allen, PhD, Department of Medicine, Vanderbilt University Medical Center; K.C. Vickers, PhD, Department of Medicine, Vanderbilt University Medical Center; C.M. Stein, MBChB, Department of Medicine, Vanderbilt University Medical Center. Address correspondence to Dr. M.J. Ormseth, 1161 21st Ave. South, T-3113 MCN, Nashville, Tennessee 37232-2681, USA. E-mail: michelle.ormseth@vumc.org. Accepted for publication May 1, 2019.
Kasey C. Vickers
From the Tennessee Valley Healthcare System, US Department of Veterans Affairs; Department of Medicine, Vanderbilt University Medical Center; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee; Department of Bioinformatics, University of New Mexico, Albuquerque, New Mexico, USA. Funded by the Veterans Health Administration CDA IK2CX001269, Arthritis Foundation Delivering on Discovery grant, Alpha Omicron Pi, US National Institutes of Health grants P60 AR056116, P01 HL116263, and CTSA award UL1TR000445 from the National Center for Advancing Translational Sciences. M.J. Ormseth, MD, Tennessee Valley Healthcare System, US Department of Veterans Affairs, and Department of Medicine, Vanderbilt University Medical Center; J.F. Solus, PhD, Department of Medicine, Vanderbilt University Medical Center; Q. Sheng, PhD, Department of Biostatistics, Vanderbilt University Medical Center; F. Ye, PhD, Department of Biostatistics, Vanderbilt University Medical Center; Q. Wu, PhD, Department of Medicine, Vanderbilt University Medical Center; Y. Guo, PhD, Department of Bioinformatics, University of New Mexico; A.M. Oeser, BA, MLAS, CCRP, Department of Medicine, Vanderbilt University Medical Center; R.M. Allen, PhD, Department of Medicine, Vanderbilt University Medical Center; K.C. Vickers, PhD, Department of Medicine, Vanderbilt University Medical Center; C.M. Stein, MBChB, Department of Medicine, Vanderbilt University Medical Center. Address correspondence to Dr. M.J. Ormseth, 1161 21st Ave. South, T-3113 MCN, Nashville, Tennessee 37232-2681, USA. E-mail: michelle.ormseth@vumc.org. Accepted for publication May 1, 2019.
C. Michael Stein
From the Tennessee Valley Healthcare System, US Department of Veterans Affairs; Department of Medicine, Vanderbilt University Medical Center; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee; Department of Bioinformatics, University of New Mexico, Albuquerque, New Mexico, USA. Funded by the Veterans Health Administration CDA IK2CX001269, Arthritis Foundation Delivering on Discovery grant, Alpha Omicron Pi, US National Institutes of Health grants P60 AR056116, P01 HL116263, and CTSA award UL1TR000445 from the National Center for Advancing Translational Sciences. M.J. Ormseth, MD, Tennessee Valley Healthcare System, US Department of Veterans Affairs, and Department of Medicine, Vanderbilt University Medical Center; J.F. Solus, PhD, Department of Medicine, Vanderbilt University Medical Center; Q. Sheng, PhD, Department of Biostatistics, Vanderbilt University Medical Center; F. Ye, PhD, Department of Biostatistics, Vanderbilt University Medical Center; Q. Wu, PhD, Department of Medicine, Vanderbilt University Medical Center; Y. Guo, PhD, Department of Bioinformatics, University of New Mexico; A.M. Oeser, BA, MLAS, CCRP, Department of Medicine, Vanderbilt University Medical Center; R.M. Allen, PhD, Department of Medicine, Vanderbilt University Medical Center; K.C. Vickers, PhD, Department of Medicine, Vanderbilt University Medical Center; C.M. Stein, MBChB, Department of Medicine, Vanderbilt University Medical Center. Address correspondence to Dr. M.J. Ormseth, 1161 21st Ave. South, T-3113 MCN, Nashville, Tennessee 37232-2681, USA. E-mail: michelle.ormseth@vumc.org. Accepted for publication May 1, 2019.
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The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Development and Validation of a MicroRNA Panel to Differentiate Between Patients with Rheumatoid Arthritis or Systemic Lupus Erythematosus and Controls
Michelle J. Ormseth, Joseph F. Solus, Quanhu Sheng, Fei Ye, Qiong Wu, Yan Guo, Annette M. Oeser, Ryan M. Allen, Kasey C. Vickers, C. Michael Stein
The Journal of Rheumatology May 2019, jrheum.181029; DOI: 10.3899/jrheum.181029
Development and Validation of a MicroRNA Panel to Differentiate Between Patients with Rheumatoid Arthritis or Systemic Lupus Erythematosus and Controls
Michelle J. Ormseth, Joseph F. Solus, Quanhu Sheng, Fei Ye, Qiong Wu, Yan Guo, Annette M. Oeser, Ryan M. Allen, Kasey C. Vickers, C. Michael Stein
The Journal of Rheumatology May 2019, jrheum.181029; DOI: 10.3899/jrheum.181029