Research ArticleArticle
Scleroderma Renal Crisis: Risk Factors for an Increasingly Rare Organ Complication
Pia Moinzadeh, Kathrin Kuhr, Elise Siegert, Norbert Blank, Cord Sunderkoetter, Jörg Henes, Martin Krusche, Marc Schmalzing, Margitta Worm, Tim Schmeiser, Claudia Günther, Elisabeth Aberer, Laura Susok, Gabriela Riemekasten, Alexander Kreuter, Gabriele Zeidler, Aaron Juche, Denitsa Hadjiski, Ulf Müller-Ladner, Noemi Gaebelein-Wissing, Jörg H.W. Distler, Miklós Sárdy, Thomas Krieg and Nicolas Hunzelmann
The Journal of Rheumatology April 2019, jrheum.180582; DOI: https://doi.org/10.3899/jrheum.180582
Pia Moinzadeh
From the Department of Dermatology and Venereology, University Hospital Cologne; Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne; Department of Rheumatology, Charité Universitätsmedizin Berlin; Department of Dermatology and Allergology, Charité Universitätsmedizin Berlin; Department of Rheumatology, Immanuel Krankenhaus Berlin-Buch, Berlin; Department of Rheumatology, University Hospital Heidelberg, Heidelberg; Department of Dermatology and Venereology, University Hospital Muenster, Muenster; University Hospital Halle, Halle; Centre for Interdisciplinary Clinical Immunology, Rheumatology and Auto-inflammatory Diseases; Department of Internal Medicine II (Oncology, Hematology, Immunology, Rheumatology, Pulmonology), University Hospital Tuebingen, Tuebingen; Department for Internal Medicine, Rheumatology, Immunology and Nephrology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, University Hospital Wuerzburg, Wuerzburg; Department of Rheumatology, Krankenhaus St. Josef; Department of Dermatology, HELIOS University Hospital Wuppertal, Wuppertal; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Dermatology and Venereology, Ruhr-University-Bochum, Bochum; Department of Rheumatology, University Medical Center-UKSH, Luebeck; Department of Dermatology, Venereology and Allergology, HELIOS St. Elisabeth Hospital Oberhausen, University Witten-Herdecke, Witten; Department of Rheumatology, Johanniter-Krankenhaus im Flaeming Treuenbrietzen, Treuenbrietzen; University Medical Center Freiburg, Freiburg; Department of Rheumatology, Justus Liebig University Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Rheumatology, University Hospital Erlangen, Erlangen; Department of Dermatology and Allergology, Ludwig Maximilian University, Munich, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. This study was supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith-Busch-Foundation. The work of P. Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology and Venereology, University Hospital Cologne; K. Kuhr, Dr. rer. nat, Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne; E. Siegert, MD, Department of Rheumatology, Charité Universitätsmedizin Berlin; N. Blank, MD, Department of Rheumatology, University Hospital Heidelberg; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster, Muenster, and University Hospital Halle; J. Henes, MD, Centre for Interdisciplinary Clinical Immunology, Rheumatology and Auto-inflammatory Diseases, and Department of Internal Medicine II (Oncology, Hematology, Immunology, Rheumatology, Pulmonology), University Hospital Tuebingen; M. Krusche, MD, Department for Internal Medicine, Rheumatology, Immunology and Nephrology, Asklepios Clinic Altona; M. Schmalzing, MD, Department of Rheumatology, University Hospital Wuerzburg; M. Worm, MD, Department of Dermatology and Allergology, Charité Universitätsmedizin Berlin; T. Schmeiser, MD, Department of Rheumatology, Krankenhaus St. Josef; C. Günther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; E. Aberer, MD, Department of Dermatology, Medical University of Graz; L. Susok, MD, Department of Dermatology and Venereology, Ruhr-University-Bochum; G. Riemekasten, MD, Department of Rheumatology, University Medical Center-UKSH; A. Kreuter, MD, Department of Dermatology, Venereology and Allergology, HELIOS St. Elisabeth Hospital Oberhausen, University Witten-Herdecke; G. Zeidler, MD, Department of Rheumatology, Johanniter-Krankenhaus im Flaeming Treuenbrietzen; A. Juche, MD, Department of Rheumatology, Immanuel Krankenhaus Berlin-Buch; D. Hadjiski, MD, University Medical Center Freiburg; U. Müller-Ladner, MD, Department of Rheumatology, Justus Liebig University Giessen, Kerckhoff Clinic; N. Gaebelein-Wissing, MD, Department of Dermatology, HELIOS University Hospital Wuppertal; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; M. Sárdy, MD, Department of Dermatology and Allergology, Ludwig Maximilian University; T. Krieg, MD, Department of Dermatology and Venereology, University Hospital Cologne; N. Hunzelmann, MD, Department of Dermatology and Venereology, University Hospital Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication March 6, 2019.
Kathrin Kuhr
From the Department of Dermatology and Venereology, University Hospital Cologne; Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne; Department of Rheumatology, Charité Universitätsmedizin Berlin; Department of Dermatology and Allergology, Charité Universitätsmedizin Berlin; Department of Rheumatology, Immanuel Krankenhaus Berlin-Buch, Berlin; Department of Rheumatology, University Hospital Heidelberg, Heidelberg; Department of Dermatology and Venereology, University Hospital Muenster, Muenster; University Hospital Halle, Halle; Centre for Interdisciplinary Clinical Immunology, Rheumatology and Auto-inflammatory Diseases; Department of Internal Medicine II (Oncology, Hematology, Immunology, Rheumatology, Pulmonology), University Hospital Tuebingen, Tuebingen; Department for Internal Medicine, Rheumatology, Immunology and Nephrology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, University Hospital Wuerzburg, Wuerzburg; Department of Rheumatology, Krankenhaus St. Josef; Department of Dermatology, HELIOS University Hospital Wuppertal, Wuppertal; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Dermatology and Venereology, Ruhr-University-Bochum, Bochum; Department of Rheumatology, University Medical Center-UKSH, Luebeck; Department of Dermatology, Venereology and Allergology, HELIOS St. Elisabeth Hospital Oberhausen, University Witten-Herdecke, Witten; Department of Rheumatology, Johanniter-Krankenhaus im Flaeming Treuenbrietzen, Treuenbrietzen; University Medical Center Freiburg, Freiburg; Department of Rheumatology, Justus Liebig University Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Rheumatology, University Hospital Erlangen, Erlangen; Department of Dermatology and Allergology, Ludwig Maximilian University, Munich, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. This study was supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith-Busch-Foundation. The work of P. Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology and Venereology, University Hospital Cologne; K. Kuhr, Dr. rer. nat, Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne; E. Siegert, MD, Department of Rheumatology, Charité Universitätsmedizin Berlin; N. Blank, MD, Department of Rheumatology, University Hospital Heidelberg; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster, Muenster, and University Hospital Halle; J. Henes, MD, Centre for Interdisciplinary Clinical Immunology, Rheumatology and Auto-inflammatory Diseases, and Department of Internal Medicine II (Oncology, Hematology, Immunology, Rheumatology, Pulmonology), University Hospital Tuebingen; M. Krusche, MD, Department for Internal Medicine, Rheumatology, Immunology and Nephrology, Asklepios Clinic Altona; M. Schmalzing, MD, Department of Rheumatology, University Hospital Wuerzburg; M. Worm, MD, Department of Dermatology and Allergology, Charité Universitätsmedizin Berlin; T. Schmeiser, MD, Department of Rheumatology, Krankenhaus St. Josef; C. Günther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; E. Aberer, MD, Department of Dermatology, Medical University of Graz; L. Susok, MD, Department of Dermatology and Venereology, Ruhr-University-Bochum; G. Riemekasten, MD, Department of Rheumatology, University Medical Center-UKSH; A. Kreuter, MD, Department of Dermatology, Venereology and Allergology, HELIOS St. Elisabeth Hospital Oberhausen, University Witten-Herdecke; G. Zeidler, MD, Department of Rheumatology, Johanniter-Krankenhaus im Flaeming Treuenbrietzen; A. Juche, MD, Department of Rheumatology, Immanuel Krankenhaus Berlin-Buch; D. Hadjiski, MD, University Medical Center Freiburg; U. Müller-Ladner, MD, Department of Rheumatology, Justus Liebig University Giessen, Kerckhoff Clinic; N. Gaebelein-Wissing, MD, Department of Dermatology, HELIOS University Hospital Wuppertal; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; M. Sárdy, MD, Department of Dermatology and Allergology, Ludwig Maximilian University; T. Krieg, MD, Department of Dermatology and Venereology, University Hospital Cologne; N. Hunzelmann, MD, Department of Dermatology and Venereology, University Hospital Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication March 6, 2019.
Elise Siegert
From the Department of Dermatology and Venereology, University Hospital Cologne; Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne; Department of Rheumatology, Charité Universitätsmedizin Berlin; Department of Dermatology and Allergology, Charité Universitätsmedizin Berlin; Department of Rheumatology, Immanuel Krankenhaus Berlin-Buch, Berlin; Department of Rheumatology, University Hospital Heidelberg, Heidelberg; Department of Dermatology and Venereology, University Hospital Muenster, Muenster; University Hospital Halle, Halle; Centre for Interdisciplinary Clinical Immunology, Rheumatology and Auto-inflammatory Diseases; Department of Internal Medicine II (Oncology, Hematology, Immunology, Rheumatology, Pulmonology), University Hospital Tuebingen, Tuebingen; Department for Internal Medicine, Rheumatology, Immunology and Nephrology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, University Hospital Wuerzburg, Wuerzburg; Department of Rheumatology, Krankenhaus St. Josef; Department of Dermatology, HELIOS University Hospital Wuppertal, Wuppertal; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Dermatology and Venereology, Ruhr-University-Bochum, Bochum; Department of Rheumatology, University Medical Center-UKSH, Luebeck; Department of Dermatology, Venereology and Allergology, HELIOS St. Elisabeth Hospital Oberhausen, University Witten-Herdecke, Witten; Department of Rheumatology, Johanniter-Krankenhaus im Flaeming Treuenbrietzen, Treuenbrietzen; University Medical Center Freiburg, Freiburg; Department of Rheumatology, Justus Liebig University Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Rheumatology, University Hospital Erlangen, Erlangen; Department of Dermatology and Allergology, Ludwig Maximilian University, Munich, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. This study was supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith-Busch-Foundation. The work of P. Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology and Venereology, University Hospital Cologne; K. Kuhr, Dr. rer. nat, Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne; E. Siegert, MD, Department of Rheumatology, Charité Universitätsmedizin Berlin; N. Blank, MD, Department of Rheumatology, University Hospital Heidelberg; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster, Muenster, and University Hospital Halle; J. Henes, MD, Centre for Interdisciplinary Clinical Immunology, Rheumatology and Auto-inflammatory Diseases, and Department of Internal Medicine II (Oncology, Hematology, Immunology, Rheumatology, Pulmonology), University Hospital Tuebingen; M. Krusche, MD, Department for Internal Medicine, Rheumatology, Immunology and Nephrology, Asklepios Clinic Altona; M. Schmalzing, MD, Department of Rheumatology, University Hospital Wuerzburg; M. Worm, MD, Department of Dermatology and Allergology, Charité Universitätsmedizin Berlin; T. Schmeiser, MD, Department of Rheumatology, Krankenhaus St. Josef; C. Günther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; E. Aberer, MD, Department of Dermatology, Medical University of Graz; L. Susok, MD, Department of Dermatology and Venereology, Ruhr-University-Bochum; G. Riemekasten, MD, Department of Rheumatology, University Medical Center-UKSH; A. Kreuter, MD, Department of Dermatology, Venereology and Allergology, HELIOS St. Elisabeth Hospital Oberhausen, University Witten-Herdecke; G. Zeidler, MD, Department of Rheumatology, Johanniter-Krankenhaus im Flaeming Treuenbrietzen; A. Juche, MD, Department of Rheumatology, Immanuel Krankenhaus Berlin-Buch; D. Hadjiski, MD, University Medical Center Freiburg; U. Müller-Ladner, MD, Department of Rheumatology, Justus Liebig University Giessen, Kerckhoff Clinic; N. Gaebelein-Wissing, MD, Department of Dermatology, HELIOS University Hospital Wuppertal; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; M. Sárdy, MD, Department of Dermatology and Allergology, Ludwig Maximilian University; T. Krieg, MD, Department of Dermatology and Venereology, University Hospital Cologne; N. Hunzelmann, MD, Department of Dermatology and Venereology, University Hospital Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication March 6, 2019.
Norbert Blank
From the Department of Dermatology and Venereology, University Hospital Cologne; Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne; Department of Rheumatology, Charité Universitätsmedizin Berlin; Department of Dermatology and Allergology, Charité Universitätsmedizin Berlin; Department of Rheumatology, Immanuel Krankenhaus Berlin-Buch, Berlin; Department of Rheumatology, University Hospital Heidelberg, Heidelberg; Department of Dermatology and Venereology, University Hospital Muenster, Muenster; University Hospital Halle, Halle; Centre for Interdisciplinary Clinical Immunology, Rheumatology and Auto-inflammatory Diseases; Department of Internal Medicine II (Oncology, Hematology, Immunology, Rheumatology, Pulmonology), University Hospital Tuebingen, Tuebingen; Department for Internal Medicine, Rheumatology, Immunology and Nephrology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, University Hospital Wuerzburg, Wuerzburg; Department of Rheumatology, Krankenhaus St. Josef; Department of Dermatology, HELIOS University Hospital Wuppertal, Wuppertal; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Dermatology and Venereology, Ruhr-University-Bochum, Bochum; Department of Rheumatology, University Medical Center-UKSH, Luebeck; Department of Dermatology, Venereology and Allergology, HELIOS St. Elisabeth Hospital Oberhausen, University Witten-Herdecke, Witten; Department of Rheumatology, Johanniter-Krankenhaus im Flaeming Treuenbrietzen, Treuenbrietzen; University Medical Center Freiburg, Freiburg; Department of Rheumatology, Justus Liebig University Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Rheumatology, University Hospital Erlangen, Erlangen; Department of Dermatology and Allergology, Ludwig Maximilian University, Munich, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. This study was supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith-Busch-Foundation. The work of P. Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology and Venereology, University Hospital Cologne; K. Kuhr, Dr. rer. nat, Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne; E. Siegert, MD, Department of Rheumatology, Charité Universitätsmedizin Berlin; N. Blank, MD, Department of Rheumatology, University Hospital Heidelberg; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster, Muenster, and University Hospital Halle; J. Henes, MD, Centre for Interdisciplinary Clinical Immunology, Rheumatology and Auto-inflammatory Diseases, and Department of Internal Medicine II (Oncology, Hematology, Immunology, Rheumatology, Pulmonology), University Hospital Tuebingen; M. Krusche, MD, Department for Internal Medicine, Rheumatology, Immunology and Nephrology, Asklepios Clinic Altona; M. Schmalzing, MD, Department of Rheumatology, University Hospital Wuerzburg; M. Worm, MD, Department of Dermatology and Allergology, Charité Universitätsmedizin Berlin; T. Schmeiser, MD, Department of Rheumatology, Krankenhaus St. Josef; C. Günther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; E. Aberer, MD, Department of Dermatology, Medical University of Graz; L. Susok, MD, Department of Dermatology and Venereology, Ruhr-University-Bochum; G. Riemekasten, MD, Department of Rheumatology, University Medical Center-UKSH; A. Kreuter, MD, Department of Dermatology, Venereology and Allergology, HELIOS St. Elisabeth Hospital Oberhausen, University Witten-Herdecke; G. Zeidler, MD, Department of Rheumatology, Johanniter-Krankenhaus im Flaeming Treuenbrietzen; A. Juche, MD, Department of Rheumatology, Immanuel Krankenhaus Berlin-Buch; D. Hadjiski, MD, University Medical Center Freiburg; U. Müller-Ladner, MD, Department of Rheumatology, Justus Liebig University Giessen, Kerckhoff Clinic; N. Gaebelein-Wissing, MD, Department of Dermatology, HELIOS University Hospital Wuppertal; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; M. Sárdy, MD, Department of Dermatology and Allergology, Ludwig Maximilian University; T. Krieg, MD, Department of Dermatology and Venereology, University Hospital Cologne; N. Hunzelmann, MD, Department of Dermatology and Venereology, University Hospital Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication March 6, 2019.
Cord Sunderkoetter
From the Department of Dermatology and Venereology, University Hospital Cologne; Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne; Department of Rheumatology, Charité Universitätsmedizin Berlin; Department of Dermatology and Allergology, Charité Universitätsmedizin Berlin; Department of Rheumatology, Immanuel Krankenhaus Berlin-Buch, Berlin; Department of Rheumatology, University Hospital Heidelberg, Heidelberg; Department of Dermatology and Venereology, University Hospital Muenster, Muenster; University Hospital Halle, Halle; Centre for Interdisciplinary Clinical Immunology, Rheumatology and Auto-inflammatory Diseases; Department of Internal Medicine II (Oncology, Hematology, Immunology, Rheumatology, Pulmonology), University Hospital Tuebingen, Tuebingen; Department for Internal Medicine, Rheumatology, Immunology and Nephrology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, University Hospital Wuerzburg, Wuerzburg; Department of Rheumatology, Krankenhaus St. Josef; Department of Dermatology, HELIOS University Hospital Wuppertal, Wuppertal; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Dermatology and Venereology, Ruhr-University-Bochum, Bochum; Department of Rheumatology, University Medical Center-UKSH, Luebeck; Department of Dermatology, Venereology and Allergology, HELIOS St. Elisabeth Hospital Oberhausen, University Witten-Herdecke, Witten; Department of Rheumatology, Johanniter-Krankenhaus im Flaeming Treuenbrietzen, Treuenbrietzen; University Medical Center Freiburg, Freiburg; Department of Rheumatology, Justus Liebig University Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Rheumatology, University Hospital Erlangen, Erlangen; Department of Dermatology and Allergology, Ludwig Maximilian University, Munich, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. This study was supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith-Busch-Foundation. The work of P. Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology and Venereology, University Hospital Cologne; K. Kuhr, Dr. rer. nat, Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne; E. Siegert, MD, Department of Rheumatology, Charité Universitätsmedizin Berlin; N. Blank, MD, Department of Rheumatology, University Hospital Heidelberg; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster, Muenster, and University Hospital Halle; J. Henes, MD, Centre for Interdisciplinary Clinical Immunology, Rheumatology and Auto-inflammatory Diseases, and Department of Internal Medicine II (Oncology, Hematology, Immunology, Rheumatology, Pulmonology), University Hospital Tuebingen; M. Krusche, MD, Department for Internal Medicine, Rheumatology, Immunology and Nephrology, Asklepios Clinic Altona; M. Schmalzing, MD, Department of Rheumatology, University Hospital Wuerzburg; M. Worm, MD, Department of Dermatology and Allergology, Charité Universitätsmedizin Berlin; T. Schmeiser, MD, Department of Rheumatology, Krankenhaus St. Josef; C. Günther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; E. Aberer, MD, Department of Dermatology, Medical University of Graz; L. Susok, MD, Department of Dermatology and Venereology, Ruhr-University-Bochum; G. Riemekasten, MD, Department of Rheumatology, University Medical Center-UKSH; A. Kreuter, MD, Department of Dermatology, Venereology and Allergology, HELIOS St. Elisabeth Hospital Oberhausen, University Witten-Herdecke; G. Zeidler, MD, Department of Rheumatology, Johanniter-Krankenhaus im Flaeming Treuenbrietzen; A. Juche, MD, Department of Rheumatology, Immanuel Krankenhaus Berlin-Buch; D. Hadjiski, MD, University Medical Center Freiburg; U. Müller-Ladner, MD, Department of Rheumatology, Justus Liebig University Giessen, Kerckhoff Clinic; N. Gaebelein-Wissing, MD, Department of Dermatology, HELIOS University Hospital Wuppertal; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; M. Sárdy, MD, Department of Dermatology and Allergology, Ludwig Maximilian University; T. Krieg, MD, Department of Dermatology and Venereology, University Hospital Cologne; N. Hunzelmann, MD, Department of Dermatology and Venereology, University Hospital Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication March 6, 2019.
Jörg Henes
From the Department of Dermatology and Venereology, University Hospital Cologne; Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne; Department of Rheumatology, Charité Universitätsmedizin Berlin; Department of Dermatology and Allergology, Charité Universitätsmedizin Berlin; Department of Rheumatology, Immanuel Krankenhaus Berlin-Buch, Berlin; Department of Rheumatology, University Hospital Heidelberg, Heidelberg; Department of Dermatology and Venereology, University Hospital Muenster, Muenster; University Hospital Halle, Halle; Centre for Interdisciplinary Clinical Immunology, Rheumatology and Auto-inflammatory Diseases; Department of Internal Medicine II (Oncology, Hematology, Immunology, Rheumatology, Pulmonology), University Hospital Tuebingen, Tuebingen; Department for Internal Medicine, Rheumatology, Immunology and Nephrology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, University Hospital Wuerzburg, Wuerzburg; Department of Rheumatology, Krankenhaus St. Josef; Department of Dermatology, HELIOS University Hospital Wuppertal, Wuppertal; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Dermatology and Venereology, Ruhr-University-Bochum, Bochum; Department of Rheumatology, University Medical Center-UKSH, Luebeck; Department of Dermatology, Venereology and Allergology, HELIOS St. Elisabeth Hospital Oberhausen, University Witten-Herdecke, Witten; Department of Rheumatology, Johanniter-Krankenhaus im Flaeming Treuenbrietzen, Treuenbrietzen; University Medical Center Freiburg, Freiburg; Department of Rheumatology, Justus Liebig University Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Rheumatology, University Hospital Erlangen, Erlangen; Department of Dermatology and Allergology, Ludwig Maximilian University, Munich, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. This study was supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith-Busch-Foundation. The work of P. Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology and Venereology, University Hospital Cologne; K. Kuhr, Dr. rer. nat, Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne; E. Siegert, MD, Department of Rheumatology, Charité Universitätsmedizin Berlin; N. Blank, MD, Department of Rheumatology, University Hospital Heidelberg; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster, Muenster, and University Hospital Halle; J. Henes, MD, Centre for Interdisciplinary Clinical Immunology, Rheumatology and Auto-inflammatory Diseases, and Department of Internal Medicine II (Oncology, Hematology, Immunology, Rheumatology, Pulmonology), University Hospital Tuebingen; M. Krusche, MD, Department for Internal Medicine, Rheumatology, Immunology and Nephrology, Asklepios Clinic Altona; M. Schmalzing, MD, Department of Rheumatology, University Hospital Wuerzburg; M. Worm, MD, Department of Dermatology and Allergology, Charité Universitätsmedizin Berlin; T. Schmeiser, MD, Department of Rheumatology, Krankenhaus St. Josef; C. Günther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; E. Aberer, MD, Department of Dermatology, Medical University of Graz; L. Susok, MD, Department of Dermatology and Venereology, Ruhr-University-Bochum; G. Riemekasten, MD, Department of Rheumatology, University Medical Center-UKSH; A. Kreuter, MD, Department of Dermatology, Venereology and Allergology, HELIOS St. Elisabeth Hospital Oberhausen, University Witten-Herdecke; G. Zeidler, MD, Department of Rheumatology, Johanniter-Krankenhaus im Flaeming Treuenbrietzen; A. Juche, MD, Department of Rheumatology, Immanuel Krankenhaus Berlin-Buch; D. Hadjiski, MD, University Medical Center Freiburg; U. Müller-Ladner, MD, Department of Rheumatology, Justus Liebig University Giessen, Kerckhoff Clinic; N. Gaebelein-Wissing, MD, Department of Dermatology, HELIOS University Hospital Wuppertal; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; M. Sárdy, MD, Department of Dermatology and Allergology, Ludwig Maximilian University; T. Krieg, MD, Department of Dermatology and Venereology, University Hospital Cologne; N. Hunzelmann, MD, Department of Dermatology and Venereology, University Hospital Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication March 6, 2019.
Martin Krusche
From the Department of Dermatology and Venereology, University Hospital Cologne; Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne; Department of Rheumatology, Charité Universitätsmedizin Berlin; Department of Dermatology and Allergology, Charité Universitätsmedizin Berlin; Department of Rheumatology, Immanuel Krankenhaus Berlin-Buch, Berlin; Department of Rheumatology, University Hospital Heidelberg, Heidelberg; Department of Dermatology and Venereology, University Hospital Muenster, Muenster; University Hospital Halle, Halle; Centre for Interdisciplinary Clinical Immunology, Rheumatology and Auto-inflammatory Diseases; Department of Internal Medicine II (Oncology, Hematology, Immunology, Rheumatology, Pulmonology), University Hospital Tuebingen, Tuebingen; Department for Internal Medicine, Rheumatology, Immunology and Nephrology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, University Hospital Wuerzburg, Wuerzburg; Department of Rheumatology, Krankenhaus St. Josef; Department of Dermatology, HELIOS University Hospital Wuppertal, Wuppertal; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Dermatology and Venereology, Ruhr-University-Bochum, Bochum; Department of Rheumatology, University Medical Center-UKSH, Luebeck; Department of Dermatology, Venereology and Allergology, HELIOS St. Elisabeth Hospital Oberhausen, University Witten-Herdecke, Witten; Department of Rheumatology, Johanniter-Krankenhaus im Flaeming Treuenbrietzen, Treuenbrietzen; University Medical Center Freiburg, Freiburg; Department of Rheumatology, Justus Liebig University Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Rheumatology, University Hospital Erlangen, Erlangen; Department of Dermatology and Allergology, Ludwig Maximilian University, Munich, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. This study was supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith-Busch-Foundation. The work of P. Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology and Venereology, University Hospital Cologne; K. Kuhr, Dr. rer. nat, Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne; E. Siegert, MD, Department of Rheumatology, Charité Universitätsmedizin Berlin; N. Blank, MD, Department of Rheumatology, University Hospital Heidelberg; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster, Muenster, and University Hospital Halle; J. Henes, MD, Centre for Interdisciplinary Clinical Immunology, Rheumatology and Auto-inflammatory Diseases, and Department of Internal Medicine II (Oncology, Hematology, Immunology, Rheumatology, Pulmonology), University Hospital Tuebingen; M. Krusche, MD, Department for Internal Medicine, Rheumatology, Immunology and Nephrology, Asklepios Clinic Altona; M. Schmalzing, MD, Department of Rheumatology, University Hospital Wuerzburg; M. Worm, MD, Department of Dermatology and Allergology, Charité Universitätsmedizin Berlin; T. Schmeiser, MD, Department of Rheumatology, Krankenhaus St. Josef; C. Günther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; E. Aberer, MD, Department of Dermatology, Medical University of Graz; L. Susok, MD, Department of Dermatology and Venereology, Ruhr-University-Bochum; G. Riemekasten, MD, Department of Rheumatology, University Medical Center-UKSH; A. Kreuter, MD, Department of Dermatology, Venereology and Allergology, HELIOS St. Elisabeth Hospital Oberhausen, University Witten-Herdecke; G. Zeidler, MD, Department of Rheumatology, Johanniter-Krankenhaus im Flaeming Treuenbrietzen; A. Juche, MD, Department of Rheumatology, Immanuel Krankenhaus Berlin-Buch; D. Hadjiski, MD, University Medical Center Freiburg; U. Müller-Ladner, MD, Department of Rheumatology, Justus Liebig University Giessen, Kerckhoff Clinic; N. Gaebelein-Wissing, MD, Department of Dermatology, HELIOS University Hospital Wuppertal; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; M. Sárdy, MD, Department of Dermatology and Allergology, Ludwig Maximilian University; T. Krieg, MD, Department of Dermatology and Venereology, University Hospital Cologne; N. Hunzelmann, MD, Department of Dermatology and Venereology, University Hospital Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication March 6, 2019.
Marc Schmalzing
From the Department of Dermatology and Venereology, University Hospital Cologne; Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne; Department of Rheumatology, Charité Universitätsmedizin Berlin; Department of Dermatology and Allergology, Charité Universitätsmedizin Berlin; Department of Rheumatology, Immanuel Krankenhaus Berlin-Buch, Berlin; Department of Rheumatology, University Hospital Heidelberg, Heidelberg; Department of Dermatology and Venereology, University Hospital Muenster, Muenster; University Hospital Halle, Halle; Centre for Interdisciplinary Clinical Immunology, Rheumatology and Auto-inflammatory Diseases; Department of Internal Medicine II (Oncology, Hematology, Immunology, Rheumatology, Pulmonology), University Hospital Tuebingen, Tuebingen; Department for Internal Medicine, Rheumatology, Immunology and Nephrology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, University Hospital Wuerzburg, Wuerzburg; Department of Rheumatology, Krankenhaus St. Josef; Department of Dermatology, HELIOS University Hospital Wuppertal, Wuppertal; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Dermatology and Venereology, Ruhr-University-Bochum, Bochum; Department of Rheumatology, University Medical Center-UKSH, Luebeck; Department of Dermatology, Venereology and Allergology, HELIOS St. Elisabeth Hospital Oberhausen, University Witten-Herdecke, Witten; Department of Rheumatology, Johanniter-Krankenhaus im Flaeming Treuenbrietzen, Treuenbrietzen; University Medical Center Freiburg, Freiburg; Department of Rheumatology, Justus Liebig University Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Rheumatology, University Hospital Erlangen, Erlangen; Department of Dermatology and Allergology, Ludwig Maximilian University, Munich, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. This study was supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith-Busch-Foundation. The work of P. Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology and Venereology, University Hospital Cologne; K. Kuhr, Dr. rer. nat, Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne; E. Siegert, MD, Department of Rheumatology, Charité Universitätsmedizin Berlin; N. Blank, MD, Department of Rheumatology, University Hospital Heidelberg; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster, Muenster, and University Hospital Halle; J. Henes, MD, Centre for Interdisciplinary Clinical Immunology, Rheumatology and Auto-inflammatory Diseases, and Department of Internal Medicine II (Oncology, Hematology, Immunology, Rheumatology, Pulmonology), University Hospital Tuebingen; M. Krusche, MD, Department for Internal Medicine, Rheumatology, Immunology and Nephrology, Asklepios Clinic Altona; M. Schmalzing, MD, Department of Rheumatology, University Hospital Wuerzburg; M. Worm, MD, Department of Dermatology and Allergology, Charité Universitätsmedizin Berlin; T. Schmeiser, MD, Department of Rheumatology, Krankenhaus St. Josef; C. Günther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; E. Aberer, MD, Department of Dermatology, Medical University of Graz; L. Susok, MD, Department of Dermatology and Venereology, Ruhr-University-Bochum; G. Riemekasten, MD, Department of Rheumatology, University Medical Center-UKSH; A. Kreuter, MD, Department of Dermatology, Venereology and Allergology, HELIOS St. Elisabeth Hospital Oberhausen, University Witten-Herdecke; G. Zeidler, MD, Department of Rheumatology, Johanniter-Krankenhaus im Flaeming Treuenbrietzen; A. Juche, MD, Department of Rheumatology, Immanuel Krankenhaus Berlin-Buch; D. Hadjiski, MD, University Medical Center Freiburg; U. Müller-Ladner, MD, Department of Rheumatology, Justus Liebig University Giessen, Kerckhoff Clinic; N. Gaebelein-Wissing, MD, Department of Dermatology, HELIOS University Hospital Wuppertal; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; M. Sárdy, MD, Department of Dermatology and Allergology, Ludwig Maximilian University; T. Krieg, MD, Department of Dermatology and Venereology, University Hospital Cologne; N. Hunzelmann, MD, Department of Dermatology and Venereology, University Hospital Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication March 6, 2019.
Margitta Worm
From the Department of Dermatology and Venereology, University Hospital Cologne; Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne; Department of Rheumatology, Charité Universitätsmedizin Berlin; Department of Dermatology and Allergology, Charité Universitätsmedizin Berlin; Department of Rheumatology, Immanuel Krankenhaus Berlin-Buch, Berlin; Department of Rheumatology, University Hospital Heidelberg, Heidelberg; Department of Dermatology and Venereology, University Hospital Muenster, Muenster; University Hospital Halle, Halle; Centre for Interdisciplinary Clinical Immunology, Rheumatology and Auto-inflammatory Diseases; Department of Internal Medicine II (Oncology, Hematology, Immunology, Rheumatology, Pulmonology), University Hospital Tuebingen, Tuebingen; Department for Internal Medicine, Rheumatology, Immunology and Nephrology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, University Hospital Wuerzburg, Wuerzburg; Department of Rheumatology, Krankenhaus St. Josef; Department of Dermatology, HELIOS University Hospital Wuppertal, Wuppertal; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Dermatology and Venereology, Ruhr-University-Bochum, Bochum; Department of Rheumatology, University Medical Center-UKSH, Luebeck; Department of Dermatology, Venereology and Allergology, HELIOS St. Elisabeth Hospital Oberhausen, University Witten-Herdecke, Witten; Department of Rheumatology, Johanniter-Krankenhaus im Flaeming Treuenbrietzen, Treuenbrietzen; University Medical Center Freiburg, Freiburg; Department of Rheumatology, Justus Liebig University Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Rheumatology, University Hospital Erlangen, Erlangen; Department of Dermatology and Allergology, Ludwig Maximilian University, Munich, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. This study was supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith-Busch-Foundation. The work of P. Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology and Venereology, University Hospital Cologne; K. Kuhr, Dr. rer. nat, Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne; E. Siegert, MD, Department of Rheumatology, Charité Universitätsmedizin Berlin; N. Blank, MD, Department of Rheumatology, University Hospital Heidelberg; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster, Muenster, and University Hospital Halle; J. Henes, MD, Centre for Interdisciplinary Clinical Immunology, Rheumatology and Auto-inflammatory Diseases, and Department of Internal Medicine II (Oncology, Hematology, Immunology, Rheumatology, Pulmonology), University Hospital Tuebingen; M. Krusche, MD, Department for Internal Medicine, Rheumatology, Immunology and Nephrology, Asklepios Clinic Altona; M. Schmalzing, MD, Department of Rheumatology, University Hospital Wuerzburg; M. Worm, MD, Department of Dermatology and Allergology, Charité Universitätsmedizin Berlin; T. Schmeiser, MD, Department of Rheumatology, Krankenhaus St. Josef; C. Günther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; E. Aberer, MD, Department of Dermatology, Medical University of Graz; L. Susok, MD, Department of Dermatology and Venereology, Ruhr-University-Bochum; G. Riemekasten, MD, Department of Rheumatology, University Medical Center-UKSH; A. Kreuter, MD, Department of Dermatology, Venereology and Allergology, HELIOS St. Elisabeth Hospital Oberhausen, University Witten-Herdecke; G. Zeidler, MD, Department of Rheumatology, Johanniter-Krankenhaus im Flaeming Treuenbrietzen; A. Juche, MD, Department of Rheumatology, Immanuel Krankenhaus Berlin-Buch; D. Hadjiski, MD, University Medical Center Freiburg; U. Müller-Ladner, MD, Department of Rheumatology, Justus Liebig University Giessen, Kerckhoff Clinic; N. Gaebelein-Wissing, MD, Department of Dermatology, HELIOS University Hospital Wuppertal; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; M. Sárdy, MD, Department of Dermatology and Allergology, Ludwig Maximilian University; T. Krieg, MD, Department of Dermatology and Venereology, University Hospital Cologne; N. Hunzelmann, MD, Department of Dermatology and Venereology, University Hospital Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication March 6, 2019.
Tim Schmeiser
From the Department of Dermatology and Venereology, University Hospital Cologne; Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne; Department of Rheumatology, Charité Universitätsmedizin Berlin; Department of Dermatology and Allergology, Charité Universitätsmedizin Berlin; Department of Rheumatology, Immanuel Krankenhaus Berlin-Buch, Berlin; Department of Rheumatology, University Hospital Heidelberg, Heidelberg; Department of Dermatology and Venereology, University Hospital Muenster, Muenster; University Hospital Halle, Halle; Centre for Interdisciplinary Clinical Immunology, Rheumatology and Auto-inflammatory Diseases; Department of Internal Medicine II (Oncology, Hematology, Immunology, Rheumatology, Pulmonology), University Hospital Tuebingen, Tuebingen; Department for Internal Medicine, Rheumatology, Immunology and Nephrology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, University Hospital Wuerzburg, Wuerzburg; Department of Rheumatology, Krankenhaus St. Josef; Department of Dermatology, HELIOS University Hospital Wuppertal, Wuppertal; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Dermatology and Venereology, Ruhr-University-Bochum, Bochum; Department of Rheumatology, University Medical Center-UKSH, Luebeck; Department of Dermatology, Venereology and Allergology, HELIOS St. Elisabeth Hospital Oberhausen, University Witten-Herdecke, Witten; Department of Rheumatology, Johanniter-Krankenhaus im Flaeming Treuenbrietzen, Treuenbrietzen; University Medical Center Freiburg, Freiburg; Department of Rheumatology, Justus Liebig University Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Rheumatology, University Hospital Erlangen, Erlangen; Department of Dermatology and Allergology, Ludwig Maximilian University, Munich, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. This study was supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith-Busch-Foundation. The work of P. Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology and Venereology, University Hospital Cologne; K. Kuhr, Dr. rer. nat, Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne; E. Siegert, MD, Department of Rheumatology, Charité Universitätsmedizin Berlin; N. Blank, MD, Department of Rheumatology, University Hospital Heidelberg; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster, Muenster, and University Hospital Halle; J. Henes, MD, Centre for Interdisciplinary Clinical Immunology, Rheumatology and Auto-inflammatory Diseases, and Department of Internal Medicine II (Oncology, Hematology, Immunology, Rheumatology, Pulmonology), University Hospital Tuebingen; M. Krusche, MD, Department for Internal Medicine, Rheumatology, Immunology and Nephrology, Asklepios Clinic Altona; M. Schmalzing, MD, Department of Rheumatology, University Hospital Wuerzburg; M. Worm, MD, Department of Dermatology and Allergology, Charité Universitätsmedizin Berlin; T. Schmeiser, MD, Department of Rheumatology, Krankenhaus St. Josef; C. Günther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; E. Aberer, MD, Department of Dermatology, Medical University of Graz; L. Susok, MD, Department of Dermatology and Venereology, Ruhr-University-Bochum; G. Riemekasten, MD, Department of Rheumatology, University Medical Center-UKSH; A. Kreuter, MD, Department of Dermatology, Venereology and Allergology, HELIOS St. Elisabeth Hospital Oberhausen, University Witten-Herdecke; G. Zeidler, MD, Department of Rheumatology, Johanniter-Krankenhaus im Flaeming Treuenbrietzen; A. Juche, MD, Department of Rheumatology, Immanuel Krankenhaus Berlin-Buch; D. Hadjiski, MD, University Medical Center Freiburg; U. Müller-Ladner, MD, Department of Rheumatology, Justus Liebig University Giessen, Kerckhoff Clinic; N. Gaebelein-Wissing, MD, Department of Dermatology, HELIOS University Hospital Wuppertal; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; M. Sárdy, MD, Department of Dermatology and Allergology, Ludwig Maximilian University; T. Krieg, MD, Department of Dermatology and Venereology, University Hospital Cologne; N. Hunzelmann, MD, Department of Dermatology and Venereology, University Hospital Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication March 6, 2019.
Claudia Günther
From the Department of Dermatology and Venereology, University Hospital Cologne; Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne; Department of Rheumatology, Charité Universitätsmedizin Berlin; Department of Dermatology and Allergology, Charité Universitätsmedizin Berlin; Department of Rheumatology, Immanuel Krankenhaus Berlin-Buch, Berlin; Department of Rheumatology, University Hospital Heidelberg, Heidelberg; Department of Dermatology and Venereology, University Hospital Muenster, Muenster; University Hospital Halle, Halle; Centre for Interdisciplinary Clinical Immunology, Rheumatology and Auto-inflammatory Diseases; Department of Internal Medicine II (Oncology, Hematology, Immunology, Rheumatology, Pulmonology), University Hospital Tuebingen, Tuebingen; Department for Internal Medicine, Rheumatology, Immunology and Nephrology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, University Hospital Wuerzburg, Wuerzburg; Department of Rheumatology, Krankenhaus St. Josef; Department of Dermatology, HELIOS University Hospital Wuppertal, Wuppertal; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Dermatology and Venereology, Ruhr-University-Bochum, Bochum; Department of Rheumatology, University Medical Center-UKSH, Luebeck; Department of Dermatology, Venereology and Allergology, HELIOS St. Elisabeth Hospital Oberhausen, University Witten-Herdecke, Witten; Department of Rheumatology, Johanniter-Krankenhaus im Flaeming Treuenbrietzen, Treuenbrietzen; University Medical Center Freiburg, Freiburg; Department of Rheumatology, Justus Liebig University Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Rheumatology, University Hospital Erlangen, Erlangen; Department of Dermatology and Allergology, Ludwig Maximilian University, Munich, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. This study was supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith-Busch-Foundation. The work of P. Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology and Venereology, University Hospital Cologne; K. Kuhr, Dr. rer. nat, Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne; E. Siegert, MD, Department of Rheumatology, Charité Universitätsmedizin Berlin; N. Blank, MD, Department of Rheumatology, University Hospital Heidelberg; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster, Muenster, and University Hospital Halle; J. Henes, MD, Centre for Interdisciplinary Clinical Immunology, Rheumatology and Auto-inflammatory Diseases, and Department of Internal Medicine II (Oncology, Hematology, Immunology, Rheumatology, Pulmonology), University Hospital Tuebingen; M. Krusche, MD, Department for Internal Medicine, Rheumatology, Immunology and Nephrology, Asklepios Clinic Altona; M. Schmalzing, MD, Department of Rheumatology, University Hospital Wuerzburg; M. Worm, MD, Department of Dermatology and Allergology, Charité Universitätsmedizin Berlin; T. Schmeiser, MD, Department of Rheumatology, Krankenhaus St. Josef; C. Günther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; E. Aberer, MD, Department of Dermatology, Medical University of Graz; L. Susok, MD, Department of Dermatology and Venereology, Ruhr-University-Bochum; G. Riemekasten, MD, Department of Rheumatology, University Medical Center-UKSH; A. Kreuter, MD, Department of Dermatology, Venereology and Allergology, HELIOS St. Elisabeth Hospital Oberhausen, University Witten-Herdecke; G. Zeidler, MD, Department of Rheumatology, Johanniter-Krankenhaus im Flaeming Treuenbrietzen; A. Juche, MD, Department of Rheumatology, Immanuel Krankenhaus Berlin-Buch; D. Hadjiski, MD, University Medical Center Freiburg; U. Müller-Ladner, MD, Department of Rheumatology, Justus Liebig University Giessen, Kerckhoff Clinic; N. Gaebelein-Wissing, MD, Department of Dermatology, HELIOS University Hospital Wuppertal; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; M. Sárdy, MD, Department of Dermatology and Allergology, Ludwig Maximilian University; T. Krieg, MD, Department of Dermatology and Venereology, University Hospital Cologne; N. Hunzelmann, MD, Department of Dermatology and Venereology, University Hospital Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication March 6, 2019.
Elisabeth Aberer
From the Department of Dermatology and Venereology, University Hospital Cologne; Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne; Department of Rheumatology, Charité Universitätsmedizin Berlin; Department of Dermatology and Allergology, Charité Universitätsmedizin Berlin; Department of Rheumatology, Immanuel Krankenhaus Berlin-Buch, Berlin; Department of Rheumatology, University Hospital Heidelberg, Heidelberg; Department of Dermatology and Venereology, University Hospital Muenster, Muenster; University Hospital Halle, Halle; Centre for Interdisciplinary Clinical Immunology, Rheumatology and Auto-inflammatory Diseases; Department of Internal Medicine II (Oncology, Hematology, Immunology, Rheumatology, Pulmonology), University Hospital Tuebingen, Tuebingen; Department for Internal Medicine, Rheumatology, Immunology and Nephrology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, University Hospital Wuerzburg, Wuerzburg; Department of Rheumatology, Krankenhaus St. Josef; Department of Dermatology, HELIOS University Hospital Wuppertal, Wuppertal; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Dermatology and Venereology, Ruhr-University-Bochum, Bochum; Department of Rheumatology, University Medical Center-UKSH, Luebeck; Department of Dermatology, Venereology and Allergology, HELIOS St. Elisabeth Hospital Oberhausen, University Witten-Herdecke, Witten; Department of Rheumatology, Johanniter-Krankenhaus im Flaeming Treuenbrietzen, Treuenbrietzen; University Medical Center Freiburg, Freiburg; Department of Rheumatology, Justus Liebig University Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Rheumatology, University Hospital Erlangen, Erlangen; Department of Dermatology and Allergology, Ludwig Maximilian University, Munich, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. This study was supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith-Busch-Foundation. The work of P. Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology and Venereology, University Hospital Cologne; K. Kuhr, Dr. rer. nat, Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne; E. Siegert, MD, Department of Rheumatology, Charité Universitätsmedizin Berlin; N. Blank, MD, Department of Rheumatology, University Hospital Heidelberg; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster, Muenster, and University Hospital Halle; J. Henes, MD, Centre for Interdisciplinary Clinical Immunology, Rheumatology and Auto-inflammatory Diseases, and Department of Internal Medicine II (Oncology, Hematology, Immunology, Rheumatology, Pulmonology), University Hospital Tuebingen; M. Krusche, MD, Department for Internal Medicine, Rheumatology, Immunology and Nephrology, Asklepios Clinic Altona; M. Schmalzing, MD, Department of Rheumatology, University Hospital Wuerzburg; M. Worm, MD, Department of Dermatology and Allergology, Charité Universitätsmedizin Berlin; T. Schmeiser, MD, Department of Rheumatology, Krankenhaus St. Josef; C. Günther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; E. Aberer, MD, Department of Dermatology, Medical University of Graz; L. Susok, MD, Department of Dermatology and Venereology, Ruhr-University-Bochum; G. Riemekasten, MD, Department of Rheumatology, University Medical Center-UKSH; A. Kreuter, MD, Department of Dermatology, Venereology and Allergology, HELIOS St. Elisabeth Hospital Oberhausen, University Witten-Herdecke; G. Zeidler, MD, Department of Rheumatology, Johanniter-Krankenhaus im Flaeming Treuenbrietzen; A. Juche, MD, Department of Rheumatology, Immanuel Krankenhaus Berlin-Buch; D. Hadjiski, MD, University Medical Center Freiburg; U. Müller-Ladner, MD, Department of Rheumatology, Justus Liebig University Giessen, Kerckhoff Clinic; N. Gaebelein-Wissing, MD, Department of Dermatology, HELIOS University Hospital Wuppertal; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; M. Sárdy, MD, Department of Dermatology and Allergology, Ludwig Maximilian University; T. Krieg, MD, Department of Dermatology and Venereology, University Hospital Cologne; N. Hunzelmann, MD, Department of Dermatology and Venereology, University Hospital Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication March 6, 2019.
Laura Susok
From the Department of Dermatology and Venereology, University Hospital Cologne; Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne; Department of Rheumatology, Charité Universitätsmedizin Berlin; Department of Dermatology and Allergology, Charité Universitätsmedizin Berlin; Department of Rheumatology, Immanuel Krankenhaus Berlin-Buch, Berlin; Department of Rheumatology, University Hospital Heidelberg, Heidelberg; Department of Dermatology and Venereology, University Hospital Muenster, Muenster; University Hospital Halle, Halle; Centre for Interdisciplinary Clinical Immunology, Rheumatology and Auto-inflammatory Diseases; Department of Internal Medicine II (Oncology, Hematology, Immunology, Rheumatology, Pulmonology), University Hospital Tuebingen, Tuebingen; Department for Internal Medicine, Rheumatology, Immunology and Nephrology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, University Hospital Wuerzburg, Wuerzburg; Department of Rheumatology, Krankenhaus St. Josef; Department of Dermatology, HELIOS University Hospital Wuppertal, Wuppertal; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Dermatology and Venereology, Ruhr-University-Bochum, Bochum; Department of Rheumatology, University Medical Center-UKSH, Luebeck; Department of Dermatology, Venereology and Allergology, HELIOS St. Elisabeth Hospital Oberhausen, University Witten-Herdecke, Witten; Department of Rheumatology, Johanniter-Krankenhaus im Flaeming Treuenbrietzen, Treuenbrietzen; University Medical Center Freiburg, Freiburg; Department of Rheumatology, Justus Liebig University Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Rheumatology, University Hospital Erlangen, Erlangen; Department of Dermatology and Allergology, Ludwig Maximilian University, Munich, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. This study was supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith-Busch-Foundation. The work of P. Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology and Venereology, University Hospital Cologne; K. Kuhr, Dr. rer. nat, Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne; E. Siegert, MD, Department of Rheumatology, Charité Universitätsmedizin Berlin; N. Blank, MD, Department of Rheumatology, University Hospital Heidelberg; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster, Muenster, and University Hospital Halle; J. Henes, MD, Centre for Interdisciplinary Clinical Immunology, Rheumatology and Auto-inflammatory Diseases, and Department of Internal Medicine II (Oncology, Hematology, Immunology, Rheumatology, Pulmonology), University Hospital Tuebingen; M. Krusche, MD, Department for Internal Medicine, Rheumatology, Immunology and Nephrology, Asklepios Clinic Altona; M. Schmalzing, MD, Department of Rheumatology, University Hospital Wuerzburg; M. Worm, MD, Department of Dermatology and Allergology, Charité Universitätsmedizin Berlin; T. Schmeiser, MD, Department of Rheumatology, Krankenhaus St. Josef; C. Günther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; E. Aberer, MD, Department of Dermatology, Medical University of Graz; L. Susok, MD, Department of Dermatology and Venereology, Ruhr-University-Bochum; G. Riemekasten, MD, Department of Rheumatology, University Medical Center-UKSH; A. Kreuter, MD, Department of Dermatology, Venereology and Allergology, HELIOS St. Elisabeth Hospital Oberhausen, University Witten-Herdecke; G. Zeidler, MD, Department of Rheumatology, Johanniter-Krankenhaus im Flaeming Treuenbrietzen; A. Juche, MD, Department of Rheumatology, Immanuel Krankenhaus Berlin-Buch; D. Hadjiski, MD, University Medical Center Freiburg; U. Müller-Ladner, MD, Department of Rheumatology, Justus Liebig University Giessen, Kerckhoff Clinic; N. Gaebelein-Wissing, MD, Department of Dermatology, HELIOS University Hospital Wuppertal; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; M. Sárdy, MD, Department of Dermatology and Allergology, Ludwig Maximilian University; T. Krieg, MD, Department of Dermatology and Venereology, University Hospital Cologne; N. Hunzelmann, MD, Department of Dermatology and Venereology, University Hospital Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication March 6, 2019.
Gabriela Riemekasten
From the Department of Dermatology and Venereology, University Hospital Cologne; Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne; Department of Rheumatology, Charité Universitätsmedizin Berlin; Department of Dermatology and Allergology, Charité Universitätsmedizin Berlin; Department of Rheumatology, Immanuel Krankenhaus Berlin-Buch, Berlin; Department of Rheumatology, University Hospital Heidelberg, Heidelberg; Department of Dermatology and Venereology, University Hospital Muenster, Muenster; University Hospital Halle, Halle; Centre for Interdisciplinary Clinical Immunology, Rheumatology and Auto-inflammatory Diseases; Department of Internal Medicine II (Oncology, Hematology, Immunology, Rheumatology, Pulmonology), University Hospital Tuebingen, Tuebingen; Department for Internal Medicine, Rheumatology, Immunology and Nephrology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, University Hospital Wuerzburg, Wuerzburg; Department of Rheumatology, Krankenhaus St. Josef; Department of Dermatology, HELIOS University Hospital Wuppertal, Wuppertal; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Dermatology and Venereology, Ruhr-University-Bochum, Bochum; Department of Rheumatology, University Medical Center-UKSH, Luebeck; Department of Dermatology, Venereology and Allergology, HELIOS St. Elisabeth Hospital Oberhausen, University Witten-Herdecke, Witten; Department of Rheumatology, Johanniter-Krankenhaus im Flaeming Treuenbrietzen, Treuenbrietzen; University Medical Center Freiburg, Freiburg; Department of Rheumatology, Justus Liebig University Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Rheumatology, University Hospital Erlangen, Erlangen; Department of Dermatology and Allergology, Ludwig Maximilian University, Munich, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. This study was supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith-Busch-Foundation. The work of P. Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology and Venereology, University Hospital Cologne; K. Kuhr, Dr. rer. nat, Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne; E. Siegert, MD, Department of Rheumatology, Charité Universitätsmedizin Berlin; N. Blank, MD, Department of Rheumatology, University Hospital Heidelberg; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster, Muenster, and University Hospital Halle; J. Henes, MD, Centre for Interdisciplinary Clinical Immunology, Rheumatology and Auto-inflammatory Diseases, and Department of Internal Medicine II (Oncology, Hematology, Immunology, Rheumatology, Pulmonology), University Hospital Tuebingen; M. Krusche, MD, Department for Internal Medicine, Rheumatology, Immunology and Nephrology, Asklepios Clinic Altona; M. Schmalzing, MD, Department of Rheumatology, University Hospital Wuerzburg; M. Worm, MD, Department of Dermatology and Allergology, Charité Universitätsmedizin Berlin; T. Schmeiser, MD, Department of Rheumatology, Krankenhaus St. Josef; C. Günther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; E. Aberer, MD, Department of Dermatology, Medical University of Graz; L. Susok, MD, Department of Dermatology and Venereology, Ruhr-University-Bochum; G. Riemekasten, MD, Department of Rheumatology, University Medical Center-UKSH; A. Kreuter, MD, Department of Dermatology, Venereology and Allergology, HELIOS St. Elisabeth Hospital Oberhausen, University Witten-Herdecke; G. Zeidler, MD, Department of Rheumatology, Johanniter-Krankenhaus im Flaeming Treuenbrietzen; A. Juche, MD, Department of Rheumatology, Immanuel Krankenhaus Berlin-Buch; D. Hadjiski, MD, University Medical Center Freiburg; U. Müller-Ladner, MD, Department of Rheumatology, Justus Liebig University Giessen, Kerckhoff Clinic; N. Gaebelein-Wissing, MD, Department of Dermatology, HELIOS University Hospital Wuppertal; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; M. Sárdy, MD, Department of Dermatology and Allergology, Ludwig Maximilian University; T. Krieg, MD, Department of Dermatology and Venereology, University Hospital Cologne; N. Hunzelmann, MD, Department of Dermatology and Venereology, University Hospital Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication March 6, 2019.
Alexander Kreuter
From the Department of Dermatology and Venereology, University Hospital Cologne; Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne; Department of Rheumatology, Charité Universitätsmedizin Berlin; Department of Dermatology and Allergology, Charité Universitätsmedizin Berlin; Department of Rheumatology, Immanuel Krankenhaus Berlin-Buch, Berlin; Department of Rheumatology, University Hospital Heidelberg, Heidelberg; Department of Dermatology and Venereology, University Hospital Muenster, Muenster; University Hospital Halle, Halle; Centre for Interdisciplinary Clinical Immunology, Rheumatology and Auto-inflammatory Diseases; Department of Internal Medicine II (Oncology, Hematology, Immunology, Rheumatology, Pulmonology), University Hospital Tuebingen, Tuebingen; Department for Internal Medicine, Rheumatology, Immunology and Nephrology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, University Hospital Wuerzburg, Wuerzburg; Department of Rheumatology, Krankenhaus St. Josef; Department of Dermatology, HELIOS University Hospital Wuppertal, Wuppertal; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Dermatology and Venereology, Ruhr-University-Bochum, Bochum; Department of Rheumatology, University Medical Center-UKSH, Luebeck; Department of Dermatology, Venereology and Allergology, HELIOS St. Elisabeth Hospital Oberhausen, University Witten-Herdecke, Witten; Department of Rheumatology, Johanniter-Krankenhaus im Flaeming Treuenbrietzen, Treuenbrietzen; University Medical Center Freiburg, Freiburg; Department of Rheumatology, Justus Liebig University Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Rheumatology, University Hospital Erlangen, Erlangen; Department of Dermatology and Allergology, Ludwig Maximilian University, Munich, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. This study was supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith-Busch-Foundation. The work of P. Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology and Venereology, University Hospital Cologne; K. Kuhr, Dr. rer. nat, Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne; E. Siegert, MD, Department of Rheumatology, Charité Universitätsmedizin Berlin; N. Blank, MD, Department of Rheumatology, University Hospital Heidelberg; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster, Muenster, and University Hospital Halle; J. Henes, MD, Centre for Interdisciplinary Clinical Immunology, Rheumatology and Auto-inflammatory Diseases, and Department of Internal Medicine II (Oncology, Hematology, Immunology, Rheumatology, Pulmonology), University Hospital Tuebingen; M. Krusche, MD, Department for Internal Medicine, Rheumatology, Immunology and Nephrology, Asklepios Clinic Altona; M. Schmalzing, MD, Department of Rheumatology, University Hospital Wuerzburg; M. Worm, MD, Department of Dermatology and Allergology, Charité Universitätsmedizin Berlin; T. Schmeiser, MD, Department of Rheumatology, Krankenhaus St. Josef; C. Günther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; E. Aberer, MD, Department of Dermatology, Medical University of Graz; L. Susok, MD, Department of Dermatology and Venereology, Ruhr-University-Bochum; G. Riemekasten, MD, Department of Rheumatology, University Medical Center-UKSH; A. Kreuter, MD, Department of Dermatology, Venereology and Allergology, HELIOS St. Elisabeth Hospital Oberhausen, University Witten-Herdecke; G. Zeidler, MD, Department of Rheumatology, Johanniter-Krankenhaus im Flaeming Treuenbrietzen; A. Juche, MD, Department of Rheumatology, Immanuel Krankenhaus Berlin-Buch; D. Hadjiski, MD, University Medical Center Freiburg; U. Müller-Ladner, MD, Department of Rheumatology, Justus Liebig University Giessen, Kerckhoff Clinic; N. Gaebelein-Wissing, MD, Department of Dermatology, HELIOS University Hospital Wuppertal; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; M. Sárdy, MD, Department of Dermatology and Allergology, Ludwig Maximilian University; T. Krieg, MD, Department of Dermatology and Venereology, University Hospital Cologne; N. Hunzelmann, MD, Department of Dermatology and Venereology, University Hospital Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication March 6, 2019.
Gabriele Zeidler
From the Department of Dermatology and Venereology, University Hospital Cologne; Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne; Department of Rheumatology, Charité Universitätsmedizin Berlin; Department of Dermatology and Allergology, Charité Universitätsmedizin Berlin; Department of Rheumatology, Immanuel Krankenhaus Berlin-Buch, Berlin; Department of Rheumatology, University Hospital Heidelberg, Heidelberg; Department of Dermatology and Venereology, University Hospital Muenster, Muenster; University Hospital Halle, Halle; Centre for Interdisciplinary Clinical Immunology, Rheumatology and Auto-inflammatory Diseases; Department of Internal Medicine II (Oncology, Hematology, Immunology, Rheumatology, Pulmonology), University Hospital Tuebingen, Tuebingen; Department for Internal Medicine, Rheumatology, Immunology and Nephrology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, University Hospital Wuerzburg, Wuerzburg; Department of Rheumatology, Krankenhaus St. Josef; Department of Dermatology, HELIOS University Hospital Wuppertal, Wuppertal; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Dermatology and Venereology, Ruhr-University-Bochum, Bochum; Department of Rheumatology, University Medical Center-UKSH, Luebeck; Department of Dermatology, Venereology and Allergology, HELIOS St. Elisabeth Hospital Oberhausen, University Witten-Herdecke, Witten; Department of Rheumatology, Johanniter-Krankenhaus im Flaeming Treuenbrietzen, Treuenbrietzen; University Medical Center Freiburg, Freiburg; Department of Rheumatology, Justus Liebig University Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Rheumatology, University Hospital Erlangen, Erlangen; Department of Dermatology and Allergology, Ludwig Maximilian University, Munich, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. This study was supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith-Busch-Foundation. The work of P. Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology and Venereology, University Hospital Cologne; K. Kuhr, Dr. rer. nat, Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne; E. Siegert, MD, Department of Rheumatology, Charité Universitätsmedizin Berlin; N. Blank, MD, Department of Rheumatology, University Hospital Heidelberg; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster, Muenster, and University Hospital Halle; J. Henes, MD, Centre for Interdisciplinary Clinical Immunology, Rheumatology and Auto-inflammatory Diseases, and Department of Internal Medicine II (Oncology, Hematology, Immunology, Rheumatology, Pulmonology), University Hospital Tuebingen; M. Krusche, MD, Department for Internal Medicine, Rheumatology, Immunology and Nephrology, Asklepios Clinic Altona; M. Schmalzing, MD, Department of Rheumatology, University Hospital Wuerzburg; M. Worm, MD, Department of Dermatology and Allergology, Charité Universitätsmedizin Berlin; T. Schmeiser, MD, Department of Rheumatology, Krankenhaus St. Josef; C. Günther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; E. Aberer, MD, Department of Dermatology, Medical University of Graz; L. Susok, MD, Department of Dermatology and Venereology, Ruhr-University-Bochum; G. Riemekasten, MD, Department of Rheumatology, University Medical Center-UKSH; A. Kreuter, MD, Department of Dermatology, Venereology and Allergology, HELIOS St. Elisabeth Hospital Oberhausen, University Witten-Herdecke; G. Zeidler, MD, Department of Rheumatology, Johanniter-Krankenhaus im Flaeming Treuenbrietzen; A. Juche, MD, Department of Rheumatology, Immanuel Krankenhaus Berlin-Buch; D. Hadjiski, MD, University Medical Center Freiburg; U. Müller-Ladner, MD, Department of Rheumatology, Justus Liebig University Giessen, Kerckhoff Clinic; N. Gaebelein-Wissing, MD, Department of Dermatology, HELIOS University Hospital Wuppertal; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; M. Sárdy, MD, Department of Dermatology and Allergology, Ludwig Maximilian University; T. Krieg, MD, Department of Dermatology and Venereology, University Hospital Cologne; N. Hunzelmann, MD, Department of Dermatology and Venereology, University Hospital Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication March 6, 2019.
Aaron Juche
From the Department of Dermatology and Venereology, University Hospital Cologne; Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne; Department of Rheumatology, Charité Universitätsmedizin Berlin; Department of Dermatology and Allergology, Charité Universitätsmedizin Berlin; Department of Rheumatology, Immanuel Krankenhaus Berlin-Buch, Berlin; Department of Rheumatology, University Hospital Heidelberg, Heidelberg; Department of Dermatology and Venereology, University Hospital Muenster, Muenster; University Hospital Halle, Halle; Centre for Interdisciplinary Clinical Immunology, Rheumatology and Auto-inflammatory Diseases; Department of Internal Medicine II (Oncology, Hematology, Immunology, Rheumatology, Pulmonology), University Hospital Tuebingen, Tuebingen; Department for Internal Medicine, Rheumatology, Immunology and Nephrology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, University Hospital Wuerzburg, Wuerzburg; Department of Rheumatology, Krankenhaus St. Josef; Department of Dermatology, HELIOS University Hospital Wuppertal, Wuppertal; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Dermatology and Venereology, Ruhr-University-Bochum, Bochum; Department of Rheumatology, University Medical Center-UKSH, Luebeck; Department of Dermatology, Venereology and Allergology, HELIOS St. Elisabeth Hospital Oberhausen, University Witten-Herdecke, Witten; Department of Rheumatology, Johanniter-Krankenhaus im Flaeming Treuenbrietzen, Treuenbrietzen; University Medical Center Freiburg, Freiburg; Department of Rheumatology, Justus Liebig University Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Rheumatology, University Hospital Erlangen, Erlangen; Department of Dermatology and Allergology, Ludwig Maximilian University, Munich, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. This study was supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith-Busch-Foundation. The work of P. Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology and Venereology, University Hospital Cologne; K. Kuhr, Dr. rer. nat, Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne; E. Siegert, MD, Department of Rheumatology, Charité Universitätsmedizin Berlin; N. Blank, MD, Department of Rheumatology, University Hospital Heidelberg; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster, Muenster, and University Hospital Halle; J. Henes, MD, Centre for Interdisciplinary Clinical Immunology, Rheumatology and Auto-inflammatory Diseases, and Department of Internal Medicine II (Oncology, Hematology, Immunology, Rheumatology, Pulmonology), University Hospital Tuebingen; M. Krusche, MD, Department for Internal Medicine, Rheumatology, Immunology and Nephrology, Asklepios Clinic Altona; M. Schmalzing, MD, Department of Rheumatology, University Hospital Wuerzburg; M. Worm, MD, Department of Dermatology and Allergology, Charité Universitätsmedizin Berlin; T. Schmeiser, MD, Department of Rheumatology, Krankenhaus St. Josef; C. Günther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; E. Aberer, MD, Department of Dermatology, Medical University of Graz; L. Susok, MD, Department of Dermatology and Venereology, Ruhr-University-Bochum; G. Riemekasten, MD, Department of Rheumatology, University Medical Center-UKSH; A. Kreuter, MD, Department of Dermatology, Venereology and Allergology, HELIOS St. Elisabeth Hospital Oberhausen, University Witten-Herdecke; G. Zeidler, MD, Department of Rheumatology, Johanniter-Krankenhaus im Flaeming Treuenbrietzen; A. Juche, MD, Department of Rheumatology, Immanuel Krankenhaus Berlin-Buch; D. Hadjiski, MD, University Medical Center Freiburg; U. Müller-Ladner, MD, Department of Rheumatology, Justus Liebig University Giessen, Kerckhoff Clinic; N. Gaebelein-Wissing, MD, Department of Dermatology, HELIOS University Hospital Wuppertal; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; M. Sárdy, MD, Department of Dermatology and Allergology, Ludwig Maximilian University; T. Krieg, MD, Department of Dermatology and Venereology, University Hospital Cologne; N. Hunzelmann, MD, Department of Dermatology and Venereology, University Hospital Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication March 6, 2019.
Denitsa Hadjiski
From the Department of Dermatology and Venereology, University Hospital Cologne; Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne; Department of Rheumatology, Charité Universitätsmedizin Berlin; Department of Dermatology and Allergology, Charité Universitätsmedizin Berlin; Department of Rheumatology, Immanuel Krankenhaus Berlin-Buch, Berlin; Department of Rheumatology, University Hospital Heidelberg, Heidelberg; Department of Dermatology and Venereology, University Hospital Muenster, Muenster; University Hospital Halle, Halle; Centre for Interdisciplinary Clinical Immunology, Rheumatology and Auto-inflammatory Diseases; Department of Internal Medicine II (Oncology, Hematology, Immunology, Rheumatology, Pulmonology), University Hospital Tuebingen, Tuebingen; Department for Internal Medicine, Rheumatology, Immunology and Nephrology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, University Hospital Wuerzburg, Wuerzburg; Department of Rheumatology, Krankenhaus St. Josef; Department of Dermatology, HELIOS University Hospital Wuppertal, Wuppertal; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Dermatology and Venereology, Ruhr-University-Bochum, Bochum; Department of Rheumatology, University Medical Center-UKSH, Luebeck; Department of Dermatology, Venereology and Allergology, HELIOS St. Elisabeth Hospital Oberhausen, University Witten-Herdecke, Witten; Department of Rheumatology, Johanniter-Krankenhaus im Flaeming Treuenbrietzen, Treuenbrietzen; University Medical Center Freiburg, Freiburg; Department of Rheumatology, Justus Liebig University Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Rheumatology, University Hospital Erlangen, Erlangen; Department of Dermatology and Allergology, Ludwig Maximilian University, Munich, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. This study was supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith-Busch-Foundation. The work of P. Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology and Venereology, University Hospital Cologne; K. Kuhr, Dr. rer. nat, Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne; E. Siegert, MD, Department of Rheumatology, Charité Universitätsmedizin Berlin; N. Blank, MD, Department of Rheumatology, University Hospital Heidelberg; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster, Muenster, and University Hospital Halle; J. Henes, MD, Centre for Interdisciplinary Clinical Immunology, Rheumatology and Auto-inflammatory Diseases, and Department of Internal Medicine II (Oncology, Hematology, Immunology, Rheumatology, Pulmonology), University Hospital Tuebingen; M. Krusche, MD, Department for Internal Medicine, Rheumatology, Immunology and Nephrology, Asklepios Clinic Altona; M. Schmalzing, MD, Department of Rheumatology, University Hospital Wuerzburg; M. Worm, MD, Department of Dermatology and Allergology, Charité Universitätsmedizin Berlin; T. Schmeiser, MD, Department of Rheumatology, Krankenhaus St. Josef; C. Günther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; E. Aberer, MD, Department of Dermatology, Medical University of Graz; L. Susok, MD, Department of Dermatology and Venereology, Ruhr-University-Bochum; G. Riemekasten, MD, Department of Rheumatology, University Medical Center-UKSH; A. Kreuter, MD, Department of Dermatology, Venereology and Allergology, HELIOS St. Elisabeth Hospital Oberhausen, University Witten-Herdecke; G. Zeidler, MD, Department of Rheumatology, Johanniter-Krankenhaus im Flaeming Treuenbrietzen; A. Juche, MD, Department of Rheumatology, Immanuel Krankenhaus Berlin-Buch; D. Hadjiski, MD, University Medical Center Freiburg; U. Müller-Ladner, MD, Department of Rheumatology, Justus Liebig University Giessen, Kerckhoff Clinic; N. Gaebelein-Wissing, MD, Department of Dermatology, HELIOS University Hospital Wuppertal; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; M. Sárdy, MD, Department of Dermatology and Allergology, Ludwig Maximilian University; T. Krieg, MD, Department of Dermatology and Venereology, University Hospital Cologne; N. Hunzelmann, MD, Department of Dermatology and Venereology, University Hospital Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication March 6, 2019.
Ulf Müller-Ladner
From the Department of Dermatology and Venereology, University Hospital Cologne; Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne; Department of Rheumatology, Charité Universitätsmedizin Berlin; Department of Dermatology and Allergology, Charité Universitätsmedizin Berlin; Department of Rheumatology, Immanuel Krankenhaus Berlin-Buch, Berlin; Department of Rheumatology, University Hospital Heidelberg, Heidelberg; Department of Dermatology and Venereology, University Hospital Muenster, Muenster; University Hospital Halle, Halle; Centre for Interdisciplinary Clinical Immunology, Rheumatology and Auto-inflammatory Diseases; Department of Internal Medicine II (Oncology, Hematology, Immunology, Rheumatology, Pulmonology), University Hospital Tuebingen, Tuebingen; Department for Internal Medicine, Rheumatology, Immunology and Nephrology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, University Hospital Wuerzburg, Wuerzburg; Department of Rheumatology, Krankenhaus St. Josef; Department of Dermatology, HELIOS University Hospital Wuppertal, Wuppertal; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Dermatology and Venereology, Ruhr-University-Bochum, Bochum; Department of Rheumatology, University Medical Center-UKSH, Luebeck; Department of Dermatology, Venereology and Allergology, HELIOS St. Elisabeth Hospital Oberhausen, University Witten-Herdecke, Witten; Department of Rheumatology, Johanniter-Krankenhaus im Flaeming Treuenbrietzen, Treuenbrietzen; University Medical Center Freiburg, Freiburg; Department of Rheumatology, Justus Liebig University Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Rheumatology, University Hospital Erlangen, Erlangen; Department of Dermatology and Allergology, Ludwig Maximilian University, Munich, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. This study was supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith-Busch-Foundation. The work of P. Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology and Venereology, University Hospital Cologne; K. Kuhr, Dr. rer. nat, Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne; E. Siegert, MD, Department of Rheumatology, Charité Universitätsmedizin Berlin; N. Blank, MD, Department of Rheumatology, University Hospital Heidelberg; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster, Muenster, and University Hospital Halle; J. Henes, MD, Centre for Interdisciplinary Clinical Immunology, Rheumatology and Auto-inflammatory Diseases, and Department of Internal Medicine II (Oncology, Hematology, Immunology, Rheumatology, Pulmonology), University Hospital Tuebingen; M. Krusche, MD, Department for Internal Medicine, Rheumatology, Immunology and Nephrology, Asklepios Clinic Altona; M. Schmalzing, MD, Department of Rheumatology, University Hospital Wuerzburg; M. Worm, MD, Department of Dermatology and Allergology, Charité Universitätsmedizin Berlin; T. Schmeiser, MD, Department of Rheumatology, Krankenhaus St. Josef; C. Günther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; E. Aberer, MD, Department of Dermatology, Medical University of Graz; L. Susok, MD, Department of Dermatology and Venereology, Ruhr-University-Bochum; G. Riemekasten, MD, Department of Rheumatology, University Medical Center-UKSH; A. Kreuter, MD, Department of Dermatology, Venereology and Allergology, HELIOS St. Elisabeth Hospital Oberhausen, University Witten-Herdecke; G. Zeidler, MD, Department of Rheumatology, Johanniter-Krankenhaus im Flaeming Treuenbrietzen; A. Juche, MD, Department of Rheumatology, Immanuel Krankenhaus Berlin-Buch; D. Hadjiski, MD, University Medical Center Freiburg; U. Müller-Ladner, MD, Department of Rheumatology, Justus Liebig University Giessen, Kerckhoff Clinic; N. Gaebelein-Wissing, MD, Department of Dermatology, HELIOS University Hospital Wuppertal; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; M. Sárdy, MD, Department of Dermatology and Allergology, Ludwig Maximilian University; T. Krieg, MD, Department of Dermatology and Venereology, University Hospital Cologne; N. Hunzelmann, MD, Department of Dermatology and Venereology, University Hospital Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication March 6, 2019.
Noemi Gaebelein-Wissing
From the Department of Dermatology and Venereology, University Hospital Cologne; Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne; Department of Rheumatology, Charité Universitätsmedizin Berlin; Department of Dermatology and Allergology, Charité Universitätsmedizin Berlin; Department of Rheumatology, Immanuel Krankenhaus Berlin-Buch, Berlin; Department of Rheumatology, University Hospital Heidelberg, Heidelberg; Department of Dermatology and Venereology, University Hospital Muenster, Muenster; University Hospital Halle, Halle; Centre for Interdisciplinary Clinical Immunology, Rheumatology and Auto-inflammatory Diseases; Department of Internal Medicine II (Oncology, Hematology, Immunology, Rheumatology, Pulmonology), University Hospital Tuebingen, Tuebingen; Department for Internal Medicine, Rheumatology, Immunology and Nephrology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, University Hospital Wuerzburg, Wuerzburg; Department of Rheumatology, Krankenhaus St. Josef; Department of Dermatology, HELIOS University Hospital Wuppertal, Wuppertal; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Dermatology and Venereology, Ruhr-University-Bochum, Bochum; Department of Rheumatology, University Medical Center-UKSH, Luebeck; Department of Dermatology, Venereology and Allergology, HELIOS St. Elisabeth Hospital Oberhausen, University Witten-Herdecke, Witten; Department of Rheumatology, Johanniter-Krankenhaus im Flaeming Treuenbrietzen, Treuenbrietzen; University Medical Center Freiburg, Freiburg; Department of Rheumatology, Justus Liebig University Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Rheumatology, University Hospital Erlangen, Erlangen; Department of Dermatology and Allergology, Ludwig Maximilian University, Munich, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. This study was supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith-Busch-Foundation. The work of P. Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology and Venereology, University Hospital Cologne; K. Kuhr, Dr. rer. nat, Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne; E. Siegert, MD, Department of Rheumatology, Charité Universitätsmedizin Berlin; N. Blank, MD, Department of Rheumatology, University Hospital Heidelberg; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster, Muenster, and University Hospital Halle; J. Henes, MD, Centre for Interdisciplinary Clinical Immunology, Rheumatology and Auto-inflammatory Diseases, and Department of Internal Medicine II (Oncology, Hematology, Immunology, Rheumatology, Pulmonology), University Hospital Tuebingen; M. Krusche, MD, Department for Internal Medicine, Rheumatology, Immunology and Nephrology, Asklepios Clinic Altona; M. Schmalzing, MD, Department of Rheumatology, University Hospital Wuerzburg; M. Worm, MD, Department of Dermatology and Allergology, Charité Universitätsmedizin Berlin; T. Schmeiser, MD, Department of Rheumatology, Krankenhaus St. Josef; C. Günther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; E. Aberer, MD, Department of Dermatology, Medical University of Graz; L. Susok, MD, Department of Dermatology and Venereology, Ruhr-University-Bochum; G. Riemekasten, MD, Department of Rheumatology, University Medical Center-UKSH; A. Kreuter, MD, Department of Dermatology, Venereology and Allergology, HELIOS St. Elisabeth Hospital Oberhausen, University Witten-Herdecke; G. Zeidler, MD, Department of Rheumatology, Johanniter-Krankenhaus im Flaeming Treuenbrietzen; A. Juche, MD, Department of Rheumatology, Immanuel Krankenhaus Berlin-Buch; D. Hadjiski, MD, University Medical Center Freiburg; U. Müller-Ladner, MD, Department of Rheumatology, Justus Liebig University Giessen, Kerckhoff Clinic; N. Gaebelein-Wissing, MD, Department of Dermatology, HELIOS University Hospital Wuppertal; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; M. Sárdy, MD, Department of Dermatology and Allergology, Ludwig Maximilian University; T. Krieg, MD, Department of Dermatology and Venereology, University Hospital Cologne; N. Hunzelmann, MD, Department of Dermatology and Venereology, University Hospital Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication March 6, 2019.
Jörg H.W. Distler
From the Department of Dermatology and Venereology, University Hospital Cologne; Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne; Department of Rheumatology, Charité Universitätsmedizin Berlin; Department of Dermatology and Allergology, Charité Universitätsmedizin Berlin; Department of Rheumatology, Immanuel Krankenhaus Berlin-Buch, Berlin; Department of Rheumatology, University Hospital Heidelberg, Heidelberg; Department of Dermatology and Venereology, University Hospital Muenster, Muenster; University Hospital Halle, Halle; Centre for Interdisciplinary Clinical Immunology, Rheumatology and Auto-inflammatory Diseases; Department of Internal Medicine II (Oncology, Hematology, Immunology, Rheumatology, Pulmonology), University Hospital Tuebingen, Tuebingen; Department for Internal Medicine, Rheumatology, Immunology and Nephrology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, University Hospital Wuerzburg, Wuerzburg; Department of Rheumatology, Krankenhaus St. Josef; Department of Dermatology, HELIOS University Hospital Wuppertal, Wuppertal; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Dermatology and Venereology, Ruhr-University-Bochum, Bochum; Department of Rheumatology, University Medical Center-UKSH, Luebeck; Department of Dermatology, Venereology and Allergology, HELIOS St. Elisabeth Hospital Oberhausen, University Witten-Herdecke, Witten; Department of Rheumatology, Johanniter-Krankenhaus im Flaeming Treuenbrietzen, Treuenbrietzen; University Medical Center Freiburg, Freiburg; Department of Rheumatology, Justus Liebig University Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Rheumatology, University Hospital Erlangen, Erlangen; Department of Dermatology and Allergology, Ludwig Maximilian University, Munich, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. This study was supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith-Busch-Foundation. The work of P. Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology and Venereology, University Hospital Cologne; K. Kuhr, Dr. rer. nat, Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne; E. Siegert, MD, Department of Rheumatology, Charité Universitätsmedizin Berlin; N. Blank, MD, Department of Rheumatology, University Hospital Heidelberg; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster, Muenster, and University Hospital Halle; J. Henes, MD, Centre for Interdisciplinary Clinical Immunology, Rheumatology and Auto-inflammatory Diseases, and Department of Internal Medicine II (Oncology, Hematology, Immunology, Rheumatology, Pulmonology), University Hospital Tuebingen; M. Krusche, MD, Department for Internal Medicine, Rheumatology, Immunology and Nephrology, Asklepios Clinic Altona; M. Schmalzing, MD, Department of Rheumatology, University Hospital Wuerzburg; M. Worm, MD, Department of Dermatology and Allergology, Charité Universitätsmedizin Berlin; T. Schmeiser, MD, Department of Rheumatology, Krankenhaus St. Josef; C. Günther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; E. Aberer, MD, Department of Dermatology, Medical University of Graz; L. Susok, MD, Department of Dermatology and Venereology, Ruhr-University-Bochum; G. Riemekasten, MD, Department of Rheumatology, University Medical Center-UKSH; A. Kreuter, MD, Department of Dermatology, Venereology and Allergology, HELIOS St. Elisabeth Hospital Oberhausen, University Witten-Herdecke; G. Zeidler, MD, Department of Rheumatology, Johanniter-Krankenhaus im Flaeming Treuenbrietzen; A. Juche, MD, Department of Rheumatology, Immanuel Krankenhaus Berlin-Buch; D. Hadjiski, MD, University Medical Center Freiburg; U. Müller-Ladner, MD, Department of Rheumatology, Justus Liebig University Giessen, Kerckhoff Clinic; N. Gaebelein-Wissing, MD, Department of Dermatology, HELIOS University Hospital Wuppertal; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; M. Sárdy, MD, Department of Dermatology and Allergology, Ludwig Maximilian University; T. Krieg, MD, Department of Dermatology and Venereology, University Hospital Cologne; N. Hunzelmann, MD, Department of Dermatology and Venereology, University Hospital Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication March 6, 2019.
Miklós Sárdy
From the Department of Dermatology and Venereology, University Hospital Cologne; Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne; Department of Rheumatology, Charité Universitätsmedizin Berlin; Department of Dermatology and Allergology, Charité Universitätsmedizin Berlin; Department of Rheumatology, Immanuel Krankenhaus Berlin-Buch, Berlin; Department of Rheumatology, University Hospital Heidelberg, Heidelberg; Department of Dermatology and Venereology, University Hospital Muenster, Muenster; University Hospital Halle, Halle; Centre for Interdisciplinary Clinical Immunology, Rheumatology and Auto-inflammatory Diseases; Department of Internal Medicine II (Oncology, Hematology, Immunology, Rheumatology, Pulmonology), University Hospital Tuebingen, Tuebingen; Department for Internal Medicine, Rheumatology, Immunology and Nephrology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, University Hospital Wuerzburg, Wuerzburg; Department of Rheumatology, Krankenhaus St. Josef; Department of Dermatology, HELIOS University Hospital Wuppertal, Wuppertal; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Dermatology and Venereology, Ruhr-University-Bochum, Bochum; Department of Rheumatology, University Medical Center-UKSH, Luebeck; Department of Dermatology, Venereology and Allergology, HELIOS St. Elisabeth Hospital Oberhausen, University Witten-Herdecke, Witten; Department of Rheumatology, Johanniter-Krankenhaus im Flaeming Treuenbrietzen, Treuenbrietzen; University Medical Center Freiburg, Freiburg; Department of Rheumatology, Justus Liebig University Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Rheumatology, University Hospital Erlangen, Erlangen; Department of Dermatology and Allergology, Ludwig Maximilian University, Munich, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. This study was supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith-Busch-Foundation. The work of P. Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology and Venereology, University Hospital Cologne; K. Kuhr, Dr. rer. nat, Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne; E. Siegert, MD, Department of Rheumatology, Charité Universitätsmedizin Berlin; N. Blank, MD, Department of Rheumatology, University Hospital Heidelberg; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster, Muenster, and University Hospital Halle; J. Henes, MD, Centre for Interdisciplinary Clinical Immunology, Rheumatology and Auto-inflammatory Diseases, and Department of Internal Medicine II (Oncology, Hematology, Immunology, Rheumatology, Pulmonology), University Hospital Tuebingen; M. Krusche, MD, Department for Internal Medicine, Rheumatology, Immunology and Nephrology, Asklepios Clinic Altona; M. Schmalzing, MD, Department of Rheumatology, University Hospital Wuerzburg; M. Worm, MD, Department of Dermatology and Allergology, Charité Universitätsmedizin Berlin; T. Schmeiser, MD, Department of Rheumatology, Krankenhaus St. Josef; C. Günther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; E. Aberer, MD, Department of Dermatology, Medical University of Graz; L. Susok, MD, Department of Dermatology and Venereology, Ruhr-University-Bochum; G. Riemekasten, MD, Department of Rheumatology, University Medical Center-UKSH; A. Kreuter, MD, Department of Dermatology, Venereology and Allergology, HELIOS St. Elisabeth Hospital Oberhausen, University Witten-Herdecke; G. Zeidler, MD, Department of Rheumatology, Johanniter-Krankenhaus im Flaeming Treuenbrietzen; A. Juche, MD, Department of Rheumatology, Immanuel Krankenhaus Berlin-Buch; D. Hadjiski, MD, University Medical Center Freiburg; U. Müller-Ladner, MD, Department of Rheumatology, Justus Liebig University Giessen, Kerckhoff Clinic; N. Gaebelein-Wissing, MD, Department of Dermatology, HELIOS University Hospital Wuppertal; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; M. Sárdy, MD, Department of Dermatology and Allergology, Ludwig Maximilian University; T. Krieg, MD, Department of Dermatology and Venereology, University Hospital Cologne; N. Hunzelmann, MD, Department of Dermatology and Venereology, University Hospital Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication March 6, 2019.
Thomas Krieg
From the Department of Dermatology and Venereology, University Hospital Cologne; Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne; Department of Rheumatology, Charité Universitätsmedizin Berlin; Department of Dermatology and Allergology, Charité Universitätsmedizin Berlin; Department of Rheumatology, Immanuel Krankenhaus Berlin-Buch, Berlin; Department of Rheumatology, University Hospital Heidelberg, Heidelberg; Department of Dermatology and Venereology, University Hospital Muenster, Muenster; University Hospital Halle, Halle; Centre for Interdisciplinary Clinical Immunology, Rheumatology and Auto-inflammatory Diseases; Department of Internal Medicine II (Oncology, Hematology, Immunology, Rheumatology, Pulmonology), University Hospital Tuebingen, Tuebingen; Department for Internal Medicine, Rheumatology, Immunology and Nephrology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, University Hospital Wuerzburg, Wuerzburg; Department of Rheumatology, Krankenhaus St. Josef; Department of Dermatology, HELIOS University Hospital Wuppertal, Wuppertal; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Dermatology and Venereology, Ruhr-University-Bochum, Bochum; Department of Rheumatology, University Medical Center-UKSH, Luebeck; Department of Dermatology, Venereology and Allergology, HELIOS St. Elisabeth Hospital Oberhausen, University Witten-Herdecke, Witten; Department of Rheumatology, Johanniter-Krankenhaus im Flaeming Treuenbrietzen, Treuenbrietzen; University Medical Center Freiburg, Freiburg; Department of Rheumatology, Justus Liebig University Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Rheumatology, University Hospital Erlangen, Erlangen; Department of Dermatology and Allergology, Ludwig Maximilian University, Munich, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. This study was supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith-Busch-Foundation. The work of P. Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology and Venereology, University Hospital Cologne; K. Kuhr, Dr. rer. nat, Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne; E. Siegert, MD, Department of Rheumatology, Charité Universitätsmedizin Berlin; N. Blank, MD, Department of Rheumatology, University Hospital Heidelberg; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster, Muenster, and University Hospital Halle; J. Henes, MD, Centre for Interdisciplinary Clinical Immunology, Rheumatology and Auto-inflammatory Diseases, and Department of Internal Medicine II (Oncology, Hematology, Immunology, Rheumatology, Pulmonology), University Hospital Tuebingen; M. Krusche, MD, Department for Internal Medicine, Rheumatology, Immunology and Nephrology, Asklepios Clinic Altona; M. Schmalzing, MD, Department of Rheumatology, University Hospital Wuerzburg; M. Worm, MD, Department of Dermatology and Allergology, Charité Universitätsmedizin Berlin; T. Schmeiser, MD, Department of Rheumatology, Krankenhaus St. Josef; C. Günther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; E. Aberer, MD, Department of Dermatology, Medical University of Graz; L. Susok, MD, Department of Dermatology and Venereology, Ruhr-University-Bochum; G. Riemekasten, MD, Department of Rheumatology, University Medical Center-UKSH; A. Kreuter, MD, Department of Dermatology, Venereology and Allergology, HELIOS St. Elisabeth Hospital Oberhausen, University Witten-Herdecke; G. Zeidler, MD, Department of Rheumatology, Johanniter-Krankenhaus im Flaeming Treuenbrietzen; A. Juche, MD, Department of Rheumatology, Immanuel Krankenhaus Berlin-Buch; D. Hadjiski, MD, University Medical Center Freiburg; U. Müller-Ladner, MD, Department of Rheumatology, Justus Liebig University Giessen, Kerckhoff Clinic; N. Gaebelein-Wissing, MD, Department of Dermatology, HELIOS University Hospital Wuppertal; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; M. Sárdy, MD, Department of Dermatology and Allergology, Ludwig Maximilian University; T. Krieg, MD, Department of Dermatology and Venereology, University Hospital Cologne; N. Hunzelmann, MD, Department of Dermatology and Venereology, University Hospital Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication March 6, 2019.
Nicolas Hunzelmann
From the Department of Dermatology and Venereology, University Hospital Cologne; Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne; Department of Rheumatology, Charité Universitätsmedizin Berlin; Department of Dermatology and Allergology, Charité Universitätsmedizin Berlin; Department of Rheumatology, Immanuel Krankenhaus Berlin-Buch, Berlin; Department of Rheumatology, University Hospital Heidelberg, Heidelberg; Department of Dermatology and Venereology, University Hospital Muenster, Muenster; University Hospital Halle, Halle; Centre for Interdisciplinary Clinical Immunology, Rheumatology and Auto-inflammatory Diseases; Department of Internal Medicine II (Oncology, Hematology, Immunology, Rheumatology, Pulmonology), University Hospital Tuebingen, Tuebingen; Department for Internal Medicine, Rheumatology, Immunology and Nephrology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, University Hospital Wuerzburg, Wuerzburg; Department of Rheumatology, Krankenhaus St. Josef; Department of Dermatology, HELIOS University Hospital Wuppertal, Wuppertal; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Dermatology and Venereology, Ruhr-University-Bochum, Bochum; Department of Rheumatology, University Medical Center-UKSH, Luebeck; Department of Dermatology, Venereology and Allergology, HELIOS St. Elisabeth Hospital Oberhausen, University Witten-Herdecke, Witten; Department of Rheumatology, Johanniter-Krankenhaus im Flaeming Treuenbrietzen, Treuenbrietzen; University Medical Center Freiburg, Freiburg; Department of Rheumatology, Justus Liebig University Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Rheumatology, University Hospital Erlangen, Erlangen; Department of Dermatology and Allergology, Ludwig Maximilian University, Munich, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria. This study was supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith-Busch-Foundation. The work of P. Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants. P. Moinzadeh, MD, Department of Dermatology and Venereology, University Hospital Cologne; K. Kuhr, Dr. rer. nat, Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne; E. Siegert, MD, Department of Rheumatology, Charité Universitätsmedizin Berlin; N. Blank, MD, Department of Rheumatology, University Hospital Heidelberg; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster, Muenster, and University Hospital Halle; J. Henes, MD, Centre for Interdisciplinary Clinical Immunology, Rheumatology and Auto-inflammatory Diseases, and Department of Internal Medicine II (Oncology, Hematology, Immunology, Rheumatology, Pulmonology), University Hospital Tuebingen; M. Krusche, MD, Department for Internal Medicine, Rheumatology, Immunology and Nephrology, Asklepios Clinic Altona; M. Schmalzing, MD, Department of Rheumatology, University Hospital Wuerzburg; M. Worm, MD, Department of Dermatology and Allergology, Charité Universitätsmedizin Berlin; T. Schmeiser, MD, Department of Rheumatology, Krankenhaus St. Josef; C. Günther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; E. Aberer, MD, Department of Dermatology, Medical University of Graz; L. Susok, MD, Department of Dermatology and Venereology, Ruhr-University-Bochum; G. Riemekasten, MD, Department of Rheumatology, University Medical Center-UKSH; A. Kreuter, MD, Department of Dermatology, Venereology and Allergology, HELIOS St. Elisabeth Hospital Oberhausen, University Witten-Herdecke; G. Zeidler, MD, Department of Rheumatology, Johanniter-Krankenhaus im Flaeming Treuenbrietzen; A. Juche, MD, Department of Rheumatology, Immanuel Krankenhaus Berlin-Buch; D. Hadjiski, MD, University Medical Center Freiburg; U. Müller-Ladner, MD, Department of Rheumatology, Justus Liebig University Giessen, Kerckhoff Clinic; N. Gaebelein-Wissing, MD, Department of Dermatology, HELIOS University Hospital Wuppertal; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; M. Sárdy, MD, Department of Dermatology and Allergology, Ludwig Maximilian University; T. Krieg, MD, Department of Dermatology and Venereology, University Hospital Cologne; N. Hunzelmann, MD, Department of Dermatology and Venereology, University Hospital Cologne. Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de. Accepted for publication March 6, 2019.
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- Published online August 15, 2019.
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- Pia Moinzadeh,
- Kathrin Kuhr,
- Elise Siegert,
- Norbert Blank,
- Cord Sunderkoetter,
- Jörg Henes,
- Martin Krusche,
- Marc Schmalzing,
- Margitta Worm,
- Tim Schmeiser,
- Claudia Günther,
- Elisabeth Aberer,
- Laura Susok,
- Gabriela Riemekasten,
- Alexander Kreuter,
- Gabriele Zeidler,
- Aaron Juche,
- Denitsa Hadjiski,
- Ulf Müller-Ladner,
- Noemi Gaebelein-Wissing,
- Jörg H.W. Distler,
- Miklós Sárdy,
- Thomas Krieg and
- Nicolas Hunzelmann
- From the Department of Dermatology and Venereology, University Hospital Cologne; Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne; Department of Rheumatology, Charité Universitätsmedizin Berlin; Department of Dermatology and Allergology, Charité Universitätsmedizin Berlin; Department of Rheumatology, Immanuel Krankenhaus Berlin-Buch, Berlin; Department of Rheumatology, University Hospital Heidelberg, Heidelberg; Department of Dermatology and Venereology, University Hospital Muenster, Muenster; University Hospital Halle, Halle; Centre for Interdisciplinary Clinical Immunology, Rheumatology and Auto-inflammatory Diseases; Department of Internal Medicine II (Oncology, Hematology, Immunology, Rheumatology, Pulmonology), University Hospital Tuebingen, Tuebingen; Department for Internal Medicine, Rheumatology, Immunology and Nephrology, Asklepios Clinic Altona, Hamburg; Department of Rheumatology, University Hospital Wuerzburg, Wuerzburg; Department of Rheumatology, Krankenhaus St. Josef; Department of Dermatology, HELIOS University Hospital Wuppertal, Wuppertal; Department of Dermatology, University Hospital Carl Gustav Carus, Dresden; Department of Dermatology and Venereology, Ruhr-University-Bochum, Bochum; Department of Rheumatology, University Medical Center-UKSH, Luebeck; Department of Dermatology, Venereology and Allergology, HELIOS St. Elisabeth Hospital Oberhausen, University Witten-Herdecke, Witten; Department of Rheumatology, Johanniter-Krankenhaus im Flaeming Treuenbrietzen, Treuenbrietzen; University Medical Center Freiburg, Freiburg; Department of Rheumatology, Justus Liebig University Giessen, Kerckhoff Clinic, Bad Nauheim; Department of Rheumatology, University Hospital Erlangen, Erlangen; Department of Dermatology and Allergology, Ludwig Maximilian University, Munich, Germany; Department of Dermatology, Medical University of Graz, Graz, Austria.
This study was supported by a grant of the German Federal Ministry of Education and Research (BMBF; 01GM0310 NH, TK; 01GM0631 CS) and the Edith-Busch-Foundation. The work of P. Moinzadeh was supported by “Koeln Fortune” (155/2014) and “Deutsche Stiftung Sklerodermie” (3649/0096/31) grants.
P. Moinzadeh, MD, Department of Dermatology and Venereology, University Hospital Cologne; K. Kuhr, Dr. rer. nat, Institute of Medical Statistics and Computational Biology, Faculty of Medicine and University Hospital Cologne, University of Cologne; E. Siegert, MD, Department of Rheumatology, Charité Universitätsmedizin Berlin; N. Blank, MD, Department of Rheumatology, University Hospital Heidelberg; C. Sunderkoetter, MD, Department of Dermatology and Venereology, University Hospital Muenster, Muenster, and University Hospital Halle; J. Henes, MD, Centre for Interdisciplinary Clinical Immunology, Rheumatology and Auto-inflammatory Diseases, and Department of Internal Medicine II (Oncology, Hematology, Immunology, Rheumatology, Pulmonology), University Hospital Tuebingen; M. Krusche, MD, Department for Internal Medicine, Rheumatology, Immunology and Nephrology, Asklepios Clinic Altona; M. Schmalzing, MD, Department of Rheumatology, University Hospital Wuerzburg; M. Worm, MD, Department of Dermatology and Allergology, Charité Universitätsmedizin Berlin; T. Schmeiser, MD, Department of Rheumatology, Krankenhaus St. Josef; C. Günther, MD, Department of Dermatology, University Hospital Carl Gustav Carus; E. Aberer, MD, Department of Dermatology, Medical University of Graz; L. Susok, MD, Department of Dermatology and Venereology, Ruhr-University-Bochum; G. Riemekasten, MD, Department of Rheumatology, University Medical Center-UKSH; A. Kreuter, MD, Department of Dermatology, Venereology and Allergology, HELIOS St. Elisabeth Hospital Oberhausen, University Witten-Herdecke; G. Zeidler, MD, Department of Rheumatology, Johanniter-Krankenhaus im Flaeming Treuenbrietzen; A. Juche, MD, Department of Rheumatology, Immanuel Krankenhaus Berlin-Buch; D. Hadjiski, MD, University Medical Center Freiburg; U. Müller-Ladner, MD, Department of Rheumatology, Justus Liebig University Giessen, Kerckhoff Clinic; N. Gaebelein-Wissing, MD, Department of Dermatology, HELIOS University Hospital Wuppertal; J.H. Distler, MD, Department of Rheumatology, University Hospital Erlangen; M. Sárdy, MD, Department of Dermatology and Allergology, Ludwig Maximilian University; T. Krieg, MD, Department of Dermatology and Venereology, University Hospital Cologne; N. Hunzelmann, MD, Department of Dermatology and Venereology, University Hospital Cologne.
Address correspondence to Dr. P. Moinzadeh, Department of Dermatology and Venereology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. E-mail: pia.moinzadeh@uk-koeln.de.
Accepted for publication March 6, 2019.
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The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Scleroderma Renal Crisis: Risk Factors for an Increasingly Rare Organ Complication
Pia Moinzadeh, Kathrin Kuhr, Elise Siegert, Norbert Blank, Cord Sunderkoetter, Jörg Henes, Martin Krusche, Marc Schmalzing, Margitta Worm, Tim Schmeiser, Claudia Günther, Elisabeth Aberer, Laura Susok, Gabriela Riemekasten, Alexander Kreuter, Gabriele Zeidler, Aaron Juche, Denitsa Hadjiski, Ulf Müller-Ladner, Noemi Gaebelein-Wissing, Jörg H.W. Distler, Miklós Sárdy, Thomas Krieg, Nicolas Hunzelmann
The Journal of Rheumatology Apr 2019, jrheum.180582; DOI: 10.3899/jrheum.180582
Scleroderma Renal Crisis: Risk Factors for an Increasingly Rare Organ Complication
Pia Moinzadeh, Kathrin Kuhr, Elise Siegert, Norbert Blank, Cord Sunderkoetter, Jörg Henes, Martin Krusche, Marc Schmalzing, Margitta Worm, Tim Schmeiser, Claudia Günther, Elisabeth Aberer, Laura Susok, Gabriela Riemekasten, Alexander Kreuter, Gabriele Zeidler, Aaron Juche, Denitsa Hadjiski, Ulf Müller-Ladner, Noemi Gaebelein-Wissing, Jörg H.W. Distler, Miklós Sárdy, Thomas Krieg, Nicolas Hunzelmann
The Journal of Rheumatology Apr 2019, jrheum.180582; DOI: 10.3899/jrheum.180582