Research ArticleArticle
Do Clinical Correlates of Knee Osteoarthritis Predict Outcome of Intraarticular Steroid Injections?
Nasimah Maricar, Matthew J. Parkes, Michael J. Callaghan, David T. Felson and Terence W. O’Neill
The Journal of Rheumatology April 2019, jrheum.180233; DOI: https://doi.org/10.3899/jrheum.180233
Nasimah Maricar
From the Arthritis Research UK Centre for Epidemiology, Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester; National Institute for Health Research (NIHR) Manchester Biomedical Research Centre, Manchester University National Health Service (NHS) Foundation Trust, Manchester Academic Health Sciences Centre; Department of Physiotherapy, Salford Royal NHS Foundation Trust; Department of Health Professions, Manchester Metropolitan University; Department of Rheumatology, Salford Royal NHS Foundation Trust, Manchester, UK; Clinical Epidemiology Unit, Boston University School of Medicine, Boston, Massachusetts, USA. This study was funded by Arthritis Research UK grant 20380, and special strategic award grant 18676. The funding agency had no role in any of the following: design and conduct of the study; collection, management, analysis, or interpretation of the data; preparation, review, or approval of the manuscript; or the decision to submit the manuscript for publication. This report includes independent research supported by (or funded by) the NIHR Biomedical Research Unit Funding Scheme. The views expressed in this publication are those of the author(s) and not necessarily those of the NHS, the NIHR, or the Department of Health. The Research in Osteoarthritis Manchester group is supported by the Manchester Academic Health Sciences Centre. Prof. D.T. Felson is supported by NIH AR4778. N. Maricar is supported by an NIHR Allied Health Profession Clinical Doctoral Fellowship. N. Maricar, PhD, MSc, BSc(Hons), Arthritis Research UK Centre for Epidemiology, Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, and NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Sciences Centre, and Department of Physiotherapy, Salford Royal NHS Foundation Trust; M.J. Parkes, BSc(Hons), Arthritis Research UK Centre for Epidemiology, Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, and NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Sciences Centre; M.J. Callaghan, Dip. in Physiotherapy, M.Phil, PhD, Arthritis Research UK Centre for Epidemiology, Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, and NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Sciences Centre, and Department of Health Professions, Manchester Metropolitan University; D.T. Felson, AB, MD, MPH, Arthritis Research UK Centre for Epidemiology, Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, and NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Sciences Centre, and Clinical Epidemiology Unit, Boston University School of Medicine; T.W. O’Neill, MD, MSc, FRCP(I), FFPH, Arthritis Research UK Centre for Epidemiology, Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, and NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Sciences Centre, and Department of Rheumatology, Salford Royal NHS Foundation Trust. Address correspondence to N. Maricar, NIHR Clinical Doctoral Fellow, Research in Osteoarthritis Manchester (ROAM), Arthritis Research UK Centre for Epidemiology, Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester M13 9PT, UK. E-mail: nasimah.maricar@manchester.ac.uk, nasimah.maricar@srft.nhs.uk. Accepted for publication March 7, 2019.
Matthew J. Parkes
From the Arthritis Research UK Centre for Epidemiology, Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester; National Institute for Health Research (NIHR) Manchester Biomedical Research Centre, Manchester University National Health Service (NHS) Foundation Trust, Manchester Academic Health Sciences Centre; Department of Physiotherapy, Salford Royal NHS Foundation Trust; Department of Health Professions, Manchester Metropolitan University; Department of Rheumatology, Salford Royal NHS Foundation Trust, Manchester, UK; Clinical Epidemiology Unit, Boston University School of Medicine, Boston, Massachusetts, USA. This study was funded by Arthritis Research UK grant 20380, and special strategic award grant 18676. The funding agency had no role in any of the following: design and conduct of the study; collection, management, analysis, or interpretation of the data; preparation, review, or approval of the manuscript; or the decision to submit the manuscript for publication. This report includes independent research supported by (or funded by) the NIHR Biomedical Research Unit Funding Scheme. The views expressed in this publication are those of the author(s) and not necessarily those of the NHS, the NIHR, or the Department of Health. The Research in Osteoarthritis Manchester group is supported by the Manchester Academic Health Sciences Centre. Prof. D.T. Felson is supported by NIH AR4778. N. Maricar is supported by an NIHR Allied Health Profession Clinical Doctoral Fellowship. N. Maricar, PhD, MSc, BSc(Hons), Arthritis Research UK Centre for Epidemiology, Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, and NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Sciences Centre, and Department of Physiotherapy, Salford Royal NHS Foundation Trust; M.J. Parkes, BSc(Hons), Arthritis Research UK Centre for Epidemiology, Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, and NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Sciences Centre; M.J. Callaghan, Dip. in Physiotherapy, M.Phil, PhD, Arthritis Research UK Centre for Epidemiology, Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, and NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Sciences Centre, and Department of Health Professions, Manchester Metropolitan University; D.T. Felson, AB, MD, MPH, Arthritis Research UK Centre for Epidemiology, Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, and NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Sciences Centre, and Clinical Epidemiology Unit, Boston University School of Medicine; T.W. O’Neill, MD, MSc, FRCP(I), FFPH, Arthritis Research UK Centre for Epidemiology, Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, and NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Sciences Centre, and Department of Rheumatology, Salford Royal NHS Foundation Trust. Address correspondence to N. Maricar, NIHR Clinical Doctoral Fellow, Research in Osteoarthritis Manchester (ROAM), Arthritis Research UK Centre for Epidemiology, Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester M13 9PT, UK. E-mail: nasimah.maricar@manchester.ac.uk, nasimah.maricar@srft.nhs.uk. Accepted for publication March 7, 2019.
Michael J. Callaghan
From the Arthritis Research UK Centre for Epidemiology, Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester; National Institute for Health Research (NIHR) Manchester Biomedical Research Centre, Manchester University National Health Service (NHS) Foundation Trust, Manchester Academic Health Sciences Centre; Department of Physiotherapy, Salford Royal NHS Foundation Trust; Department of Health Professions, Manchester Metropolitan University; Department of Rheumatology, Salford Royal NHS Foundation Trust, Manchester, UK; Clinical Epidemiology Unit, Boston University School of Medicine, Boston, Massachusetts, USA. This study was funded by Arthritis Research UK grant 20380, and special strategic award grant 18676. The funding agency had no role in any of the following: design and conduct of the study; collection, management, analysis, or interpretation of the data; preparation, review, or approval of the manuscript; or the decision to submit the manuscript for publication. This report includes independent research supported by (or funded by) the NIHR Biomedical Research Unit Funding Scheme. The views expressed in this publication are those of the author(s) and not necessarily those of the NHS, the NIHR, or the Department of Health. The Research in Osteoarthritis Manchester group is supported by the Manchester Academic Health Sciences Centre. Prof. D.T. Felson is supported by NIH AR4778. N. Maricar is supported by an NIHR Allied Health Profession Clinical Doctoral Fellowship. N. Maricar, PhD, MSc, BSc(Hons), Arthritis Research UK Centre for Epidemiology, Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, and NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Sciences Centre, and Department of Physiotherapy, Salford Royal NHS Foundation Trust; M.J. Parkes, BSc(Hons), Arthritis Research UK Centre for Epidemiology, Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, and NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Sciences Centre; M.J. Callaghan, Dip. in Physiotherapy, M.Phil, PhD, Arthritis Research UK Centre for Epidemiology, Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, and NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Sciences Centre, and Department of Health Professions, Manchester Metropolitan University; D.T. Felson, AB, MD, MPH, Arthritis Research UK Centre for Epidemiology, Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, and NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Sciences Centre, and Clinical Epidemiology Unit, Boston University School of Medicine; T.W. O’Neill, MD, MSc, FRCP(I), FFPH, Arthritis Research UK Centre for Epidemiology, Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, and NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Sciences Centre, and Department of Rheumatology, Salford Royal NHS Foundation Trust. Address correspondence to N. Maricar, NIHR Clinical Doctoral Fellow, Research in Osteoarthritis Manchester (ROAM), Arthritis Research UK Centre for Epidemiology, Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester M13 9PT, UK. E-mail: nasimah.maricar@manchester.ac.uk, nasimah.maricar@srft.nhs.uk. Accepted for publication March 7, 2019.
David T. Felson
From the Arthritis Research UK Centre for Epidemiology, Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester; National Institute for Health Research (NIHR) Manchester Biomedical Research Centre, Manchester University National Health Service (NHS) Foundation Trust, Manchester Academic Health Sciences Centre; Department of Physiotherapy, Salford Royal NHS Foundation Trust; Department of Health Professions, Manchester Metropolitan University; Department of Rheumatology, Salford Royal NHS Foundation Trust, Manchester, UK; Clinical Epidemiology Unit, Boston University School of Medicine, Boston, Massachusetts, USA. This study was funded by Arthritis Research UK grant 20380, and special strategic award grant 18676. The funding agency had no role in any of the following: design and conduct of the study; collection, management, analysis, or interpretation of the data; preparation, review, or approval of the manuscript; or the decision to submit the manuscript for publication. This report includes independent research supported by (or funded by) the NIHR Biomedical Research Unit Funding Scheme. The views expressed in this publication are those of the author(s) and not necessarily those of the NHS, the NIHR, or the Department of Health. The Research in Osteoarthritis Manchester group is supported by the Manchester Academic Health Sciences Centre. Prof. D.T. Felson is supported by NIH AR4778. N. Maricar is supported by an NIHR Allied Health Profession Clinical Doctoral Fellowship. N. Maricar, PhD, MSc, BSc(Hons), Arthritis Research UK Centre for Epidemiology, Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, and NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Sciences Centre, and Department of Physiotherapy, Salford Royal NHS Foundation Trust; M.J. Parkes, BSc(Hons), Arthritis Research UK Centre for Epidemiology, Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, and NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Sciences Centre; M.J. Callaghan, Dip. in Physiotherapy, M.Phil, PhD, Arthritis Research UK Centre for Epidemiology, Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, and NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Sciences Centre, and Department of Health Professions, Manchester Metropolitan University; D.T. Felson, AB, MD, MPH, Arthritis Research UK Centre for Epidemiology, Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, and NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Sciences Centre, and Clinical Epidemiology Unit, Boston University School of Medicine; T.W. O’Neill, MD, MSc, FRCP(I), FFPH, Arthritis Research UK Centre for Epidemiology, Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, and NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Sciences Centre, and Department of Rheumatology, Salford Royal NHS Foundation Trust. Address correspondence to N. Maricar, NIHR Clinical Doctoral Fellow, Research in Osteoarthritis Manchester (ROAM), Arthritis Research UK Centre for Epidemiology, Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester M13 9PT, UK. E-mail: nasimah.maricar@manchester.ac.uk, nasimah.maricar@srft.nhs.uk. Accepted for publication March 7, 2019.
Terence W. O’Neill
From the Arthritis Research UK Centre for Epidemiology, Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester; National Institute for Health Research (NIHR) Manchester Biomedical Research Centre, Manchester University National Health Service (NHS) Foundation Trust, Manchester Academic Health Sciences Centre; Department of Physiotherapy, Salford Royal NHS Foundation Trust; Department of Health Professions, Manchester Metropolitan University; Department of Rheumatology, Salford Royal NHS Foundation Trust, Manchester, UK; Clinical Epidemiology Unit, Boston University School of Medicine, Boston, Massachusetts, USA. This study was funded by Arthritis Research UK grant 20380, and special strategic award grant 18676. The funding agency had no role in any of the following: design and conduct of the study; collection, management, analysis, or interpretation of the data; preparation, review, or approval of the manuscript; or the decision to submit the manuscript for publication. This report includes independent research supported by (or funded by) the NIHR Biomedical Research Unit Funding Scheme. The views expressed in this publication are those of the author(s) and not necessarily those of the NHS, the NIHR, or the Department of Health. The Research in Osteoarthritis Manchester group is supported by the Manchester Academic Health Sciences Centre. Prof. D.T. Felson is supported by NIH AR4778. N. Maricar is supported by an NIHR Allied Health Profession Clinical Doctoral Fellowship. N. Maricar, PhD, MSc, BSc(Hons), Arthritis Research UK Centre for Epidemiology, Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, and NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Sciences Centre, and Department of Physiotherapy, Salford Royal NHS Foundation Trust; M.J. Parkes, BSc(Hons), Arthritis Research UK Centre for Epidemiology, Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, and NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Sciences Centre; M.J. Callaghan, Dip. in Physiotherapy, M.Phil, PhD, Arthritis Research UK Centre for Epidemiology, Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, and NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Sciences Centre, and Department of Health Professions, Manchester Metropolitan University; D.T. Felson, AB, MD, MPH, Arthritis Research UK Centre for Epidemiology, Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, and NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Sciences Centre, and Clinical Epidemiology Unit, Boston University School of Medicine; T.W. O’Neill, MD, MSc, FRCP(I), FFPH, Arthritis Research UK Centre for Epidemiology, Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, and NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Sciences Centre, and Department of Rheumatology, Salford Royal NHS Foundation Trust. Address correspondence to N. Maricar, NIHR Clinical Doctoral Fellow, Research in Osteoarthritis Manchester (ROAM), Arthritis Research UK Centre for Epidemiology, Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester M13 9PT, UK. E-mail: nasimah.maricar@manchester.ac.uk, nasimah.maricar@srft.nhs.uk. Accepted for publication March 7, 2019.
In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Do Clinical Correlates of Knee Osteoarthritis Predict Outcome of Intraarticular Steroid Injections?
Nasimah Maricar, Matthew J. Parkes, Michael J. Callaghan, David T. Felson, Terence W. O’Neill
The Journal of Rheumatology Apr 2019, jrheum.180233; DOI: 10.3899/jrheum.180233