Research ArticleArticle
Prediction of Ankylosing Spondylitis in the HUNT Study by a Genetic Risk Score Combining 110 Single-nucleotide Polymorphisms of Genome-wide Significance
Sina Rostami, Mari Hoff, Matthew A. Brown, Kristian Hveem, Oddgeir L. Holmen, Lars G. Fritsche and Vibeke Videm
The Journal of Rheumatology April 2019, jrheum.181209; DOI: https://doi.org/10.3899/jrheum.181209
Sina Rostami
From the Department of Clinical and Molecular Medicine, Department of Neuromedicine and Movement Science, and Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, NTNU - Norwegian University of Science and Technology, Trondheim; Department of Rheumatology and Department of Immunology and Transfusion Medicine, St. Olavs University Hospital, Trondheim, Norway; Institute of Health and Biomedical Innovation, Translational Research Institute, Princess Alexandra Hospital, Queensland University of Technology, Brisbane, Australia; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA. This study was supported by the Liaison Committee between the Central Norway Regional Health Authority and NTNU (grant 5056/46051000 to VV), and the Research Council of Norway (project 249944 to SR and VV). MAB is supported by a National Health and Medical Research Council Senior Principal Research Fellowship (APP1024879). S. Rostami, MSc, PhD Candidate, Department of Clinical and Molecular Medicine, NTNU; M. Hoff, MD, PhD, Rheumatologist, Associate Professor, Department of Rheumatology, St. Olavs University Hospital, and Department of Neuromedicine and Movement Science, and Department of Public Health and Nursing, NTNU; M.A. Brown, MBBS, MD, FRACP, FAHMS, FAA, Director of Genomics, Institute of Health and Biomedical Innovation, Translational Research Institute, Princess Alexandra Hospital, Queensland University of Technology; K. Hveem, MD, PhD, Professor, KG Jebsen Center for Genetic Epidemiology, NTNU; O.L. Holmen, MD, PhD, Researcher, KG Jebsen Center for Genetic Epidemiology, NTNU; L.G. Fritsche, PhD, Assistant Research Scientist, KG Jebsen Center for Genetic Epidemiology, NTNU, and Department of Biostatistics and Center for Statistical Genetics, University of Michigan; V. Videm, MD, PhD, Professor, Department of Clinical and Molecular Medicine, NTNU, and Department of Immunology and Transfusion Medicine, St. Olavs University Hospital. Address correspondence to Dr. V. Videm, Department of Clinical and Molecular Medicine, Lab Center 3 East, St. Olavs Hospital, NO-7006 Trondheim, Norway. E-mail: vibeke.videm@ntnu.no. Accepted for publication March 19, 2019.
Mari Hoff
From the Department of Clinical and Molecular Medicine, Department of Neuromedicine and Movement Science, and Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, NTNU - Norwegian University of Science and Technology, Trondheim; Department of Rheumatology and Department of Immunology and Transfusion Medicine, St. Olavs University Hospital, Trondheim, Norway; Institute of Health and Biomedical Innovation, Translational Research Institute, Princess Alexandra Hospital, Queensland University of Technology, Brisbane, Australia; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA. This study was supported by the Liaison Committee between the Central Norway Regional Health Authority and NTNU (grant 5056/46051000 to VV), and the Research Council of Norway (project 249944 to SR and VV). MAB is supported by a National Health and Medical Research Council Senior Principal Research Fellowship (APP1024879). S. Rostami, MSc, PhD Candidate, Department of Clinical and Molecular Medicine, NTNU; M. Hoff, MD, PhD, Rheumatologist, Associate Professor, Department of Rheumatology, St. Olavs University Hospital, and Department of Neuromedicine and Movement Science, and Department of Public Health and Nursing, NTNU; M.A. Brown, MBBS, MD, FRACP, FAHMS, FAA, Director of Genomics, Institute of Health and Biomedical Innovation, Translational Research Institute, Princess Alexandra Hospital, Queensland University of Technology; K. Hveem, MD, PhD, Professor, KG Jebsen Center for Genetic Epidemiology, NTNU; O.L. Holmen, MD, PhD, Researcher, KG Jebsen Center for Genetic Epidemiology, NTNU; L.G. Fritsche, PhD, Assistant Research Scientist, KG Jebsen Center for Genetic Epidemiology, NTNU, and Department of Biostatistics and Center for Statistical Genetics, University of Michigan; V. Videm, MD, PhD, Professor, Department of Clinical and Molecular Medicine, NTNU, and Department of Immunology and Transfusion Medicine, St. Olavs University Hospital. Address correspondence to Dr. V. Videm, Department of Clinical and Molecular Medicine, Lab Center 3 East, St. Olavs Hospital, NO-7006 Trondheim, Norway. E-mail: vibeke.videm@ntnu.no. Accepted for publication March 19, 2019.
Matthew A. Brown
From the Department of Clinical and Molecular Medicine, Department of Neuromedicine and Movement Science, and Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, NTNU - Norwegian University of Science and Technology, Trondheim; Department of Rheumatology and Department of Immunology and Transfusion Medicine, St. Olavs University Hospital, Trondheim, Norway; Institute of Health and Biomedical Innovation, Translational Research Institute, Princess Alexandra Hospital, Queensland University of Technology, Brisbane, Australia; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA. This study was supported by the Liaison Committee between the Central Norway Regional Health Authority and NTNU (grant 5056/46051000 to VV), and the Research Council of Norway (project 249944 to SR and VV). MAB is supported by a National Health and Medical Research Council Senior Principal Research Fellowship (APP1024879). S. Rostami, MSc, PhD Candidate, Department of Clinical and Molecular Medicine, NTNU; M. Hoff, MD, PhD, Rheumatologist, Associate Professor, Department of Rheumatology, St. Olavs University Hospital, and Department of Neuromedicine and Movement Science, and Department of Public Health and Nursing, NTNU; M.A. Brown, MBBS, MD, FRACP, FAHMS, FAA, Director of Genomics, Institute of Health and Biomedical Innovation, Translational Research Institute, Princess Alexandra Hospital, Queensland University of Technology; K. Hveem, MD, PhD, Professor, KG Jebsen Center for Genetic Epidemiology, NTNU; O.L. Holmen, MD, PhD, Researcher, KG Jebsen Center for Genetic Epidemiology, NTNU; L.G. Fritsche, PhD, Assistant Research Scientist, KG Jebsen Center for Genetic Epidemiology, NTNU, and Department of Biostatistics and Center for Statistical Genetics, University of Michigan; V. Videm, MD, PhD, Professor, Department of Clinical and Molecular Medicine, NTNU, and Department of Immunology and Transfusion Medicine, St. Olavs University Hospital. Address correspondence to Dr. V. Videm, Department of Clinical and Molecular Medicine, Lab Center 3 East, St. Olavs Hospital, NO-7006 Trondheim, Norway. E-mail: vibeke.videm@ntnu.no. Accepted for publication March 19, 2019.
Kristian Hveem
From the Department of Clinical and Molecular Medicine, Department of Neuromedicine and Movement Science, and Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, NTNU - Norwegian University of Science and Technology, Trondheim; Department of Rheumatology and Department of Immunology and Transfusion Medicine, St. Olavs University Hospital, Trondheim, Norway; Institute of Health and Biomedical Innovation, Translational Research Institute, Princess Alexandra Hospital, Queensland University of Technology, Brisbane, Australia; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA. This study was supported by the Liaison Committee between the Central Norway Regional Health Authority and NTNU (grant 5056/46051000 to VV), and the Research Council of Norway (project 249944 to SR and VV). MAB is supported by a National Health and Medical Research Council Senior Principal Research Fellowship (APP1024879). S. Rostami, MSc, PhD Candidate, Department of Clinical and Molecular Medicine, NTNU; M. Hoff, MD, PhD, Rheumatologist, Associate Professor, Department of Rheumatology, St. Olavs University Hospital, and Department of Neuromedicine and Movement Science, and Department of Public Health and Nursing, NTNU; M.A. Brown, MBBS, MD, FRACP, FAHMS, FAA, Director of Genomics, Institute of Health and Biomedical Innovation, Translational Research Institute, Princess Alexandra Hospital, Queensland University of Technology; K. Hveem, MD, PhD, Professor, KG Jebsen Center for Genetic Epidemiology, NTNU; O.L. Holmen, MD, PhD, Researcher, KG Jebsen Center for Genetic Epidemiology, NTNU; L.G. Fritsche, PhD, Assistant Research Scientist, KG Jebsen Center for Genetic Epidemiology, NTNU, and Department of Biostatistics and Center for Statistical Genetics, University of Michigan; V. Videm, MD, PhD, Professor, Department of Clinical and Molecular Medicine, NTNU, and Department of Immunology and Transfusion Medicine, St. Olavs University Hospital. Address correspondence to Dr. V. Videm, Department of Clinical and Molecular Medicine, Lab Center 3 East, St. Olavs Hospital, NO-7006 Trondheim, Norway. E-mail: vibeke.videm@ntnu.no. Accepted for publication March 19, 2019.
Oddgeir L. Holmen
From the Department of Clinical and Molecular Medicine, Department of Neuromedicine and Movement Science, and Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, NTNU - Norwegian University of Science and Technology, Trondheim; Department of Rheumatology and Department of Immunology and Transfusion Medicine, St. Olavs University Hospital, Trondheim, Norway; Institute of Health and Biomedical Innovation, Translational Research Institute, Princess Alexandra Hospital, Queensland University of Technology, Brisbane, Australia; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA. This study was supported by the Liaison Committee between the Central Norway Regional Health Authority and NTNU (grant 5056/46051000 to VV), and the Research Council of Norway (project 249944 to SR and VV). MAB is supported by a National Health and Medical Research Council Senior Principal Research Fellowship (APP1024879). S. Rostami, MSc, PhD Candidate, Department of Clinical and Molecular Medicine, NTNU; M. Hoff, MD, PhD, Rheumatologist, Associate Professor, Department of Rheumatology, St. Olavs University Hospital, and Department of Neuromedicine and Movement Science, and Department of Public Health and Nursing, NTNU; M.A. Brown, MBBS, MD, FRACP, FAHMS, FAA, Director of Genomics, Institute of Health and Biomedical Innovation, Translational Research Institute, Princess Alexandra Hospital, Queensland University of Technology; K. Hveem, MD, PhD, Professor, KG Jebsen Center for Genetic Epidemiology, NTNU; O.L. Holmen, MD, PhD, Researcher, KG Jebsen Center for Genetic Epidemiology, NTNU; L.G. Fritsche, PhD, Assistant Research Scientist, KG Jebsen Center for Genetic Epidemiology, NTNU, and Department of Biostatistics and Center for Statistical Genetics, University of Michigan; V. Videm, MD, PhD, Professor, Department of Clinical and Molecular Medicine, NTNU, and Department of Immunology and Transfusion Medicine, St. Olavs University Hospital. Address correspondence to Dr. V. Videm, Department of Clinical and Molecular Medicine, Lab Center 3 East, St. Olavs Hospital, NO-7006 Trondheim, Norway. E-mail: vibeke.videm@ntnu.no. Accepted for publication March 19, 2019.
Lars G. Fritsche
From the Department of Clinical and Molecular Medicine, Department of Neuromedicine and Movement Science, and Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, NTNU - Norwegian University of Science and Technology, Trondheim; Department of Rheumatology and Department of Immunology and Transfusion Medicine, St. Olavs University Hospital, Trondheim, Norway; Institute of Health and Biomedical Innovation, Translational Research Institute, Princess Alexandra Hospital, Queensland University of Technology, Brisbane, Australia; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA. This study was supported by the Liaison Committee between the Central Norway Regional Health Authority and NTNU (grant 5056/46051000 to VV), and the Research Council of Norway (project 249944 to SR and VV). MAB is supported by a National Health and Medical Research Council Senior Principal Research Fellowship (APP1024879). S. Rostami, MSc, PhD Candidate, Department of Clinical and Molecular Medicine, NTNU; M. Hoff, MD, PhD, Rheumatologist, Associate Professor, Department of Rheumatology, St. Olavs University Hospital, and Department of Neuromedicine and Movement Science, and Department of Public Health and Nursing, NTNU; M.A. Brown, MBBS, MD, FRACP, FAHMS, FAA, Director of Genomics, Institute of Health and Biomedical Innovation, Translational Research Institute, Princess Alexandra Hospital, Queensland University of Technology; K. Hveem, MD, PhD, Professor, KG Jebsen Center for Genetic Epidemiology, NTNU; O.L. Holmen, MD, PhD, Researcher, KG Jebsen Center for Genetic Epidemiology, NTNU; L.G. Fritsche, PhD, Assistant Research Scientist, KG Jebsen Center for Genetic Epidemiology, NTNU, and Department of Biostatistics and Center for Statistical Genetics, University of Michigan; V. Videm, MD, PhD, Professor, Department of Clinical and Molecular Medicine, NTNU, and Department of Immunology and Transfusion Medicine, St. Olavs University Hospital. Address correspondence to Dr. V. Videm, Department of Clinical and Molecular Medicine, Lab Center 3 East, St. Olavs Hospital, NO-7006 Trondheim, Norway. E-mail: vibeke.videm@ntnu.no. Accepted for publication March 19, 2019.
Vibeke Videm
From the Department of Clinical and Molecular Medicine, Department of Neuromedicine and Movement Science, and Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, NTNU - Norwegian University of Science and Technology, Trondheim; Department of Rheumatology and Department of Immunology and Transfusion Medicine, St. Olavs University Hospital, Trondheim, Norway; Institute of Health and Biomedical Innovation, Translational Research Institute, Princess Alexandra Hospital, Queensland University of Technology, Brisbane, Australia; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA. This study was supported by the Liaison Committee between the Central Norway Regional Health Authority and NTNU (grant 5056/46051000 to VV), and the Research Council of Norway (project 249944 to SR and VV). MAB is supported by a National Health and Medical Research Council Senior Principal Research Fellowship (APP1024879). S. Rostami, MSc, PhD Candidate, Department of Clinical and Molecular Medicine, NTNU; M. Hoff, MD, PhD, Rheumatologist, Associate Professor, Department of Rheumatology, St. Olavs University Hospital, and Department of Neuromedicine and Movement Science, and Department of Public Health and Nursing, NTNU; M.A. Brown, MBBS, MD, FRACP, FAHMS, FAA, Director of Genomics, Institute of Health and Biomedical Innovation, Translational Research Institute, Princess Alexandra Hospital, Queensland University of Technology; K. Hveem, MD, PhD, Professor, KG Jebsen Center for Genetic Epidemiology, NTNU; O.L. Holmen, MD, PhD, Researcher, KG Jebsen Center for Genetic Epidemiology, NTNU; L.G. Fritsche, PhD, Assistant Research Scientist, KG Jebsen Center for Genetic Epidemiology, NTNU, and Department of Biostatistics and Center for Statistical Genetics, University of Michigan; V. Videm, MD, PhD, Professor, Department of Clinical and Molecular Medicine, NTNU, and Department of Immunology and Transfusion Medicine, St. Olavs University Hospital. Address correspondence to Dr. V. Videm, Department of Clinical and Molecular Medicine, Lab Center 3 East, St. Olavs Hospital, NO-7006 Trondheim, Norway. E-mail: vibeke.videm@ntnu.no. Accepted for publication March 19, 2019.
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In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Prediction of Ankylosing Spondylitis in the HUNT Study by a Genetic Risk Score Combining 110 Single-nucleotide Polymorphisms of Genome-wide Significance
Sina Rostami, Mari Hoff, Matthew A. Brown, Kristian Hveem, Oddgeir L. Holmen, Lars G. Fritsche, Vibeke Videm
The Journal of Rheumatology Apr 2019, jrheum.181209; DOI: 10.3899/jrheum.181209
Prediction of Ankylosing Spondylitis in the HUNT Study by a Genetic Risk Score Combining 110 Single-nucleotide Polymorphisms of Genome-wide Significance
Sina Rostami, Mari Hoff, Matthew A. Brown, Kristian Hveem, Oddgeir L. Holmen, Lars G. Fritsche, Vibeke Videm
The Journal of Rheumatology Apr 2019, jrheum.181209; DOI: 10.3899/jrheum.181209