Research ArticleArticle
Longterm Efficacy and Safety of Monotherapy versus Combination Therapy in Systemic Sclerosis–associated Pulmonary Arterial Hypertension: A Retrospective RESCLE Registry Study
Melani Pestaña-Fernández, Manuel Rubio-Rivas, Carles Tolosa-Vilella, Alfredo Guillén-Del-Castillo, Mayka Freire, Jose Antonio Vargas-Hitos, Jose Antonio Todolí-Parra, Mónica Rodríguez-Carballeira, Adela Marín-Ballvé, Gerard Espinosa, Dolores Colunga-Argüelles, Norberto Ortego-Centeno, Luis Trapiella-Martínez, Cristina Carbonell-Muñoz, Xavier Pla-Salas, Isabel Perales-Fraile, Xavier Corbella, Vicent Fonollosa-Pla and Carmen Pilar Simeón-Aznar for the RESCLE investigators, Autoimmune Diseases Study Group (GEAS)
The Journal of Rheumatology February 2019, jrheum.180595; DOI: https://doi.org/10.3899/jrheum.180595
Melani Pestaña-Fernández
From the Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat, Barcelona; Department of Internal Medicine, Corporación Sanitaria Universitaria Parc Taulí, Sabadell, Barcelona; Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron, Barcelona; Unit of Systemic Autoimmune Diseases and Thrombosis, Department of Internal Medicine, Complejo Hospitalario Universitario de Vigo, Vigo, Pontevedra; Department of Internal Medicine, Hospital Universitario Virgen de las Nieves, Granada; Department of Internal Medicine, Hospital Universitario y Politécnico La Fe, Valencia; Department of Internal Medicine, Hospital Universitario Mútua Terrassa, Terrassa, Barcelona; Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Clínico Universitario Lozano Blesa, Zaragoza; Department of Systemic Autoimmune Diseases, Clinical Institute of Medicine and Dermatology, Hospital Universitario Clinic, Barcelona; Department of Internal Medicine, Hospital Universitario Central de Asturias, Oviedo, Asturias; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital Campus de la Salud, Complejo Universitario de Granada, Granada; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital de Cabueñes, Gijón, Asturias; Department of Internal Medicine, Complejo Asistencial Universitario de Salamanca, Salamanca; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Consorci Hospitalari de Vic, Vic, Barcelona; Department of Internal Medicine, Hospital Universitario Rey Juan Carlos, Móstoles, Madrid; Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya, Barcelona, Spain. This project was possible thanks to an unrestricted educational scholarship granted by Laboratorios Actelion. M. Pestaña-Fernández, MD, Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat; M. Rubio-Rivas, MD, PhD, Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat; C. Tolosa-Vilella, MD, PhD, Department of Internal Medicine, Corporación Sanitaria Universitaria Parc Taulí; A. Guillén-Del-Castillo, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron; M. Freire, MD, PhD, Unit of Systemic Autoimmune Diseases and Thrombosis, Department of Internal Medicine, Complejo Hospitalario Universitario de Vigo; J.A. Vargas-Hitos, MD, PhD, Department of Internal Medicine, Hospital Universitario Virgen de las Nieves; J.A. Todolí-Parra, MD, Department of Internal Medicine, Hospital Universitario y Politécnico La Fe; M. Rodríguez Carballeira, MD, PhD, Department of Internal Medicine, Hospital Universitario Mútua Terrassa; A. Marín-Ballvé, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Clínico Universitario Lozano Blesa; G. Espinosa, MD, PhD, Department of Systemic Autoimmune Diseases, Clinical Institute of Medicine and Dermatology, Hospital Universitario Clinic; D. Colunga-Argüelles, MD, Department of Internal Medicine, Hospital Universitario Central de Asturias; N. Ortego-Centeno, MD, PhD, Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital Campus de la Salud, Complejo Universitario de Granada; L. Trapiella-Martínez, MD, PhD, Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital de Cabueñes; C. Carbonell-Muñoz, MD, Department of Internal Medicine, Complejo Asistencial Universitario de Salamanca; X. Pla-Salas, MD, Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Consorci Hospitalari de Vic; I. Perales-Fraile, MD, Department of Internal Medicine, Hospital Universitario Rey Juan Carlos; X. Corbella, MD, PhD, Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat, and Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya; V. Fonollosa-Pla, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron; C.P. Simeón Aznar, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron. Address correspondence to Dr. M. Pestaña-Fernández, Bellvitge University Hospital, Department of Internal Medicine, Feixa Llarga, s/n, 08907 L’Hospitalet de Llobregat, Barcelona, Spain. E-mail: Melani.Pestana@sanitatintegral.org. Accepted for publication January 25, 2019.
Manuel Rubio-Rivas
From the Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat, Barcelona; Department of Internal Medicine, Corporación Sanitaria Universitaria Parc Taulí, Sabadell, Barcelona; Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron, Barcelona; Unit of Systemic Autoimmune Diseases and Thrombosis, Department of Internal Medicine, Complejo Hospitalario Universitario de Vigo, Vigo, Pontevedra; Department of Internal Medicine, Hospital Universitario Virgen de las Nieves, Granada; Department of Internal Medicine, Hospital Universitario y Politécnico La Fe, Valencia; Department of Internal Medicine, Hospital Universitario Mútua Terrassa, Terrassa, Barcelona; Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Clínico Universitario Lozano Blesa, Zaragoza; Department of Systemic Autoimmune Diseases, Clinical Institute of Medicine and Dermatology, Hospital Universitario Clinic, Barcelona; Department of Internal Medicine, Hospital Universitario Central de Asturias, Oviedo, Asturias; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital Campus de la Salud, Complejo Universitario de Granada, Granada; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital de Cabueñes, Gijón, Asturias; Department of Internal Medicine, Complejo Asistencial Universitario de Salamanca, Salamanca; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Consorci Hospitalari de Vic, Vic, Barcelona; Department of Internal Medicine, Hospital Universitario Rey Juan Carlos, Móstoles, Madrid; Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya, Barcelona, Spain. This project was possible thanks to an unrestricted educational scholarship granted by Laboratorios Actelion. M. Pestaña-Fernández, MD, Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat; M. Rubio-Rivas, MD, PhD, Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat; C. Tolosa-Vilella, MD, PhD, Department of Internal Medicine, Corporación Sanitaria Universitaria Parc Taulí; A. Guillén-Del-Castillo, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron; M. Freire, MD, PhD, Unit of Systemic Autoimmune Diseases and Thrombosis, Department of Internal Medicine, Complejo Hospitalario Universitario de Vigo; J.A. Vargas-Hitos, MD, PhD, Department of Internal Medicine, Hospital Universitario Virgen de las Nieves; J.A. Todolí-Parra, MD, Department of Internal Medicine, Hospital Universitario y Politécnico La Fe; M. Rodríguez Carballeira, MD, PhD, Department of Internal Medicine, Hospital Universitario Mútua Terrassa; A. Marín-Ballvé, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Clínico Universitario Lozano Blesa; G. Espinosa, MD, PhD, Department of Systemic Autoimmune Diseases, Clinical Institute of Medicine and Dermatology, Hospital Universitario Clinic; D. Colunga-Argüelles, MD, Department of Internal Medicine, Hospital Universitario Central de Asturias; N. Ortego-Centeno, MD, PhD, Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital Campus de la Salud, Complejo Universitario de Granada; L. Trapiella-Martínez, MD, PhD, Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital de Cabueñes; C. Carbonell-Muñoz, MD, Department of Internal Medicine, Complejo Asistencial Universitario de Salamanca; X. Pla-Salas, MD, Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Consorci Hospitalari de Vic; I. Perales-Fraile, MD, Department of Internal Medicine, Hospital Universitario Rey Juan Carlos; X. Corbella, MD, PhD, Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat, and Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya; V. Fonollosa-Pla, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron; C.P. Simeón Aznar, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron. Address correspondence to Dr. M. Pestaña-Fernández, Bellvitge University Hospital, Department of Internal Medicine, Feixa Llarga, s/n, 08907 L’Hospitalet de Llobregat, Barcelona, Spain. E-mail: Melani.Pestana@sanitatintegral.org. Accepted for publication January 25, 2019.
Carles Tolosa-Vilella
From the Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat, Barcelona; Department of Internal Medicine, Corporación Sanitaria Universitaria Parc Taulí, Sabadell, Barcelona; Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron, Barcelona; Unit of Systemic Autoimmune Diseases and Thrombosis, Department of Internal Medicine, Complejo Hospitalario Universitario de Vigo, Vigo, Pontevedra; Department of Internal Medicine, Hospital Universitario Virgen de las Nieves, Granada; Department of Internal Medicine, Hospital Universitario y Politécnico La Fe, Valencia; Department of Internal Medicine, Hospital Universitario Mútua Terrassa, Terrassa, Barcelona; Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Clínico Universitario Lozano Blesa, Zaragoza; Department of Systemic Autoimmune Diseases, Clinical Institute of Medicine and Dermatology, Hospital Universitario Clinic, Barcelona; Department of Internal Medicine, Hospital Universitario Central de Asturias, Oviedo, Asturias; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital Campus de la Salud, Complejo Universitario de Granada, Granada; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital de Cabueñes, Gijón, Asturias; Department of Internal Medicine, Complejo Asistencial Universitario de Salamanca, Salamanca; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Consorci Hospitalari de Vic, Vic, Barcelona; Department of Internal Medicine, Hospital Universitario Rey Juan Carlos, Móstoles, Madrid; Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya, Barcelona, Spain. This project was possible thanks to an unrestricted educational scholarship granted by Laboratorios Actelion. M. Pestaña-Fernández, MD, Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat; M. Rubio-Rivas, MD, PhD, Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat; C. Tolosa-Vilella, MD, PhD, Department of Internal Medicine, Corporación Sanitaria Universitaria Parc Taulí; A. Guillén-Del-Castillo, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron; M. Freire, MD, PhD, Unit of Systemic Autoimmune Diseases and Thrombosis, Department of Internal Medicine, Complejo Hospitalario Universitario de Vigo; J.A. Vargas-Hitos, MD, PhD, Department of Internal Medicine, Hospital Universitario Virgen de las Nieves; J.A. Todolí-Parra, MD, Department of Internal Medicine, Hospital Universitario y Politécnico La Fe; M. Rodríguez Carballeira, MD, PhD, Department of Internal Medicine, Hospital Universitario Mútua Terrassa; A. Marín-Ballvé, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Clínico Universitario Lozano Blesa; G. Espinosa, MD, PhD, Department of Systemic Autoimmune Diseases, Clinical Institute of Medicine and Dermatology, Hospital Universitario Clinic; D. Colunga-Argüelles, MD, Department of Internal Medicine, Hospital Universitario Central de Asturias; N. Ortego-Centeno, MD, PhD, Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital Campus de la Salud, Complejo Universitario de Granada; L. Trapiella-Martínez, MD, PhD, Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital de Cabueñes; C. Carbonell-Muñoz, MD, Department of Internal Medicine, Complejo Asistencial Universitario de Salamanca; X. Pla-Salas, MD, Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Consorci Hospitalari de Vic; I. Perales-Fraile, MD, Department of Internal Medicine, Hospital Universitario Rey Juan Carlos; X. Corbella, MD, PhD, Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat, and Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya; V. Fonollosa-Pla, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron; C.P. Simeón Aznar, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron. Address correspondence to Dr. M. Pestaña-Fernández, Bellvitge University Hospital, Department of Internal Medicine, Feixa Llarga, s/n, 08907 L’Hospitalet de Llobregat, Barcelona, Spain. E-mail: Melani.Pestana@sanitatintegral.org. Accepted for publication January 25, 2019.
Alfredo Guillén-Del-Castillo
From the Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat, Barcelona; Department of Internal Medicine, Corporación Sanitaria Universitaria Parc Taulí, Sabadell, Barcelona; Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron, Barcelona; Unit of Systemic Autoimmune Diseases and Thrombosis, Department of Internal Medicine, Complejo Hospitalario Universitario de Vigo, Vigo, Pontevedra; Department of Internal Medicine, Hospital Universitario Virgen de las Nieves, Granada; Department of Internal Medicine, Hospital Universitario y Politécnico La Fe, Valencia; Department of Internal Medicine, Hospital Universitario Mútua Terrassa, Terrassa, Barcelona; Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Clínico Universitario Lozano Blesa, Zaragoza; Department of Systemic Autoimmune Diseases, Clinical Institute of Medicine and Dermatology, Hospital Universitario Clinic, Barcelona; Department of Internal Medicine, Hospital Universitario Central de Asturias, Oviedo, Asturias; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital Campus de la Salud, Complejo Universitario de Granada, Granada; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital de Cabueñes, Gijón, Asturias; Department of Internal Medicine, Complejo Asistencial Universitario de Salamanca, Salamanca; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Consorci Hospitalari de Vic, Vic, Barcelona; Department of Internal Medicine, Hospital Universitario Rey Juan Carlos, Móstoles, Madrid; Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya, Barcelona, Spain. This project was possible thanks to an unrestricted educational scholarship granted by Laboratorios Actelion. M. Pestaña-Fernández, MD, Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat; M. Rubio-Rivas, MD, PhD, Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat; C. Tolosa-Vilella, MD, PhD, Department of Internal Medicine, Corporación Sanitaria Universitaria Parc Taulí; A. Guillén-Del-Castillo, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron; M. Freire, MD, PhD, Unit of Systemic Autoimmune Diseases and Thrombosis, Department of Internal Medicine, Complejo Hospitalario Universitario de Vigo; J.A. Vargas-Hitos, MD, PhD, Department of Internal Medicine, Hospital Universitario Virgen de las Nieves; J.A. Todolí-Parra, MD, Department of Internal Medicine, Hospital Universitario y Politécnico La Fe; M. Rodríguez Carballeira, MD, PhD, Department of Internal Medicine, Hospital Universitario Mútua Terrassa; A. Marín-Ballvé, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Clínico Universitario Lozano Blesa; G. Espinosa, MD, PhD, Department of Systemic Autoimmune Diseases, Clinical Institute of Medicine and Dermatology, Hospital Universitario Clinic; D. Colunga-Argüelles, MD, Department of Internal Medicine, Hospital Universitario Central de Asturias; N. Ortego-Centeno, MD, PhD, Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital Campus de la Salud, Complejo Universitario de Granada; L. Trapiella-Martínez, MD, PhD, Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital de Cabueñes; C. Carbonell-Muñoz, MD, Department of Internal Medicine, Complejo Asistencial Universitario de Salamanca; X. Pla-Salas, MD, Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Consorci Hospitalari de Vic; I. Perales-Fraile, MD, Department of Internal Medicine, Hospital Universitario Rey Juan Carlos; X. Corbella, MD, PhD, Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat, and Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya; V. Fonollosa-Pla, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron; C.P. Simeón Aznar, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron. Address correspondence to Dr. M. Pestaña-Fernández, Bellvitge University Hospital, Department of Internal Medicine, Feixa Llarga, s/n, 08907 L’Hospitalet de Llobregat, Barcelona, Spain. E-mail: Melani.Pestana@sanitatintegral.org. Accepted for publication January 25, 2019.
Mayka Freire
From the Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat, Barcelona; Department of Internal Medicine, Corporación Sanitaria Universitaria Parc Taulí, Sabadell, Barcelona; Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron, Barcelona; Unit of Systemic Autoimmune Diseases and Thrombosis, Department of Internal Medicine, Complejo Hospitalario Universitario de Vigo, Vigo, Pontevedra; Department of Internal Medicine, Hospital Universitario Virgen de las Nieves, Granada; Department of Internal Medicine, Hospital Universitario y Politécnico La Fe, Valencia; Department of Internal Medicine, Hospital Universitario Mútua Terrassa, Terrassa, Barcelona; Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Clínico Universitario Lozano Blesa, Zaragoza; Department of Systemic Autoimmune Diseases, Clinical Institute of Medicine and Dermatology, Hospital Universitario Clinic, Barcelona; Department of Internal Medicine, Hospital Universitario Central de Asturias, Oviedo, Asturias; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital Campus de la Salud, Complejo Universitario de Granada, Granada; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital de Cabueñes, Gijón, Asturias; Department of Internal Medicine, Complejo Asistencial Universitario de Salamanca, Salamanca; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Consorci Hospitalari de Vic, Vic, Barcelona; Department of Internal Medicine, Hospital Universitario Rey Juan Carlos, Móstoles, Madrid; Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya, Barcelona, Spain. This project was possible thanks to an unrestricted educational scholarship granted by Laboratorios Actelion. M. Pestaña-Fernández, MD, Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat; M. Rubio-Rivas, MD, PhD, Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat; C. Tolosa-Vilella, MD, PhD, Department of Internal Medicine, Corporación Sanitaria Universitaria Parc Taulí; A. Guillén-Del-Castillo, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron; M. Freire, MD, PhD, Unit of Systemic Autoimmune Diseases and Thrombosis, Department of Internal Medicine, Complejo Hospitalario Universitario de Vigo; J.A. Vargas-Hitos, MD, PhD, Department of Internal Medicine, Hospital Universitario Virgen de las Nieves; J.A. Todolí-Parra, MD, Department of Internal Medicine, Hospital Universitario y Politécnico La Fe; M. Rodríguez Carballeira, MD, PhD, Department of Internal Medicine, Hospital Universitario Mútua Terrassa; A. Marín-Ballvé, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Clínico Universitario Lozano Blesa; G. Espinosa, MD, PhD, Department of Systemic Autoimmune Diseases, Clinical Institute of Medicine and Dermatology, Hospital Universitario Clinic; D. Colunga-Argüelles, MD, Department of Internal Medicine, Hospital Universitario Central de Asturias; N. Ortego-Centeno, MD, PhD, Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital Campus de la Salud, Complejo Universitario de Granada; L. Trapiella-Martínez, MD, PhD, Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital de Cabueñes; C. Carbonell-Muñoz, MD, Department of Internal Medicine, Complejo Asistencial Universitario de Salamanca; X. Pla-Salas, MD, Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Consorci Hospitalari de Vic; I. Perales-Fraile, MD, Department of Internal Medicine, Hospital Universitario Rey Juan Carlos; X. Corbella, MD, PhD, Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat, and Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya; V. Fonollosa-Pla, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron; C.P. Simeón Aznar, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron. Address correspondence to Dr. M. Pestaña-Fernández, Bellvitge University Hospital, Department of Internal Medicine, Feixa Llarga, s/n, 08907 L’Hospitalet de Llobregat, Barcelona, Spain. E-mail: Melani.Pestana@sanitatintegral.org. Accepted for publication January 25, 2019.
Jose Antonio Vargas-Hitos
From the Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat, Barcelona; Department of Internal Medicine, Corporación Sanitaria Universitaria Parc Taulí, Sabadell, Barcelona; Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron, Barcelona; Unit of Systemic Autoimmune Diseases and Thrombosis, Department of Internal Medicine, Complejo Hospitalario Universitario de Vigo, Vigo, Pontevedra; Department of Internal Medicine, Hospital Universitario Virgen de las Nieves, Granada; Department of Internal Medicine, Hospital Universitario y Politécnico La Fe, Valencia; Department of Internal Medicine, Hospital Universitario Mútua Terrassa, Terrassa, Barcelona; Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Clínico Universitario Lozano Blesa, Zaragoza; Department of Systemic Autoimmune Diseases, Clinical Institute of Medicine and Dermatology, Hospital Universitario Clinic, Barcelona; Department of Internal Medicine, Hospital Universitario Central de Asturias, Oviedo, Asturias; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital Campus de la Salud, Complejo Universitario de Granada, Granada; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital de Cabueñes, Gijón, Asturias; Department of Internal Medicine, Complejo Asistencial Universitario de Salamanca, Salamanca; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Consorci Hospitalari de Vic, Vic, Barcelona; Department of Internal Medicine, Hospital Universitario Rey Juan Carlos, Móstoles, Madrid; Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya, Barcelona, Spain. This project was possible thanks to an unrestricted educational scholarship granted by Laboratorios Actelion. M. Pestaña-Fernández, MD, Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat; M. Rubio-Rivas, MD, PhD, Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat; C. Tolosa-Vilella, MD, PhD, Department of Internal Medicine, Corporación Sanitaria Universitaria Parc Taulí; A. Guillén-Del-Castillo, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron; M. Freire, MD, PhD, Unit of Systemic Autoimmune Diseases and Thrombosis, Department of Internal Medicine, Complejo Hospitalario Universitario de Vigo; J.A. Vargas-Hitos, MD, PhD, Department of Internal Medicine, Hospital Universitario Virgen de las Nieves; J.A. Todolí-Parra, MD, Department of Internal Medicine, Hospital Universitario y Politécnico La Fe; M. Rodríguez Carballeira, MD, PhD, Department of Internal Medicine, Hospital Universitario Mútua Terrassa; A. Marín-Ballvé, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Clínico Universitario Lozano Blesa; G. Espinosa, MD, PhD, Department of Systemic Autoimmune Diseases, Clinical Institute of Medicine and Dermatology, Hospital Universitario Clinic; D. Colunga-Argüelles, MD, Department of Internal Medicine, Hospital Universitario Central de Asturias; N. Ortego-Centeno, MD, PhD, Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital Campus de la Salud, Complejo Universitario de Granada; L. Trapiella-Martínez, MD, PhD, Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital de Cabueñes; C. Carbonell-Muñoz, MD, Department of Internal Medicine, Complejo Asistencial Universitario de Salamanca; X. Pla-Salas, MD, Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Consorci Hospitalari de Vic; I. Perales-Fraile, MD, Department of Internal Medicine, Hospital Universitario Rey Juan Carlos; X. Corbella, MD, PhD, Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat, and Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya; V. Fonollosa-Pla, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron; C.P. Simeón Aznar, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron. Address correspondence to Dr. M. Pestaña-Fernández, Bellvitge University Hospital, Department of Internal Medicine, Feixa Llarga, s/n, 08907 L’Hospitalet de Llobregat, Barcelona, Spain. E-mail: Melani.Pestana@sanitatintegral.org. Accepted for publication January 25, 2019.
Jose Antonio Todolí-Parra
From the Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat, Barcelona; Department of Internal Medicine, Corporación Sanitaria Universitaria Parc Taulí, Sabadell, Barcelona; Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron, Barcelona; Unit of Systemic Autoimmune Diseases and Thrombosis, Department of Internal Medicine, Complejo Hospitalario Universitario de Vigo, Vigo, Pontevedra; Department of Internal Medicine, Hospital Universitario Virgen de las Nieves, Granada; Department of Internal Medicine, Hospital Universitario y Politécnico La Fe, Valencia; Department of Internal Medicine, Hospital Universitario Mútua Terrassa, Terrassa, Barcelona; Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Clínico Universitario Lozano Blesa, Zaragoza; Department of Systemic Autoimmune Diseases, Clinical Institute of Medicine and Dermatology, Hospital Universitario Clinic, Barcelona; Department of Internal Medicine, Hospital Universitario Central de Asturias, Oviedo, Asturias; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital Campus de la Salud, Complejo Universitario de Granada, Granada; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital de Cabueñes, Gijón, Asturias; Department of Internal Medicine, Complejo Asistencial Universitario de Salamanca, Salamanca; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Consorci Hospitalari de Vic, Vic, Barcelona; Department of Internal Medicine, Hospital Universitario Rey Juan Carlos, Móstoles, Madrid; Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya, Barcelona, Spain. This project was possible thanks to an unrestricted educational scholarship granted by Laboratorios Actelion. M. Pestaña-Fernández, MD, Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat; M. Rubio-Rivas, MD, PhD, Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat; C. Tolosa-Vilella, MD, PhD, Department of Internal Medicine, Corporación Sanitaria Universitaria Parc Taulí; A. Guillén-Del-Castillo, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron; M. Freire, MD, PhD, Unit of Systemic Autoimmune Diseases and Thrombosis, Department of Internal Medicine, Complejo Hospitalario Universitario de Vigo; J.A. Vargas-Hitos, MD, PhD, Department of Internal Medicine, Hospital Universitario Virgen de las Nieves; J.A. Todolí-Parra, MD, Department of Internal Medicine, Hospital Universitario y Politécnico La Fe; M. Rodríguez Carballeira, MD, PhD, Department of Internal Medicine, Hospital Universitario Mútua Terrassa; A. Marín-Ballvé, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Clínico Universitario Lozano Blesa; G. Espinosa, MD, PhD, Department of Systemic Autoimmune Diseases, Clinical Institute of Medicine and Dermatology, Hospital Universitario Clinic; D. Colunga-Argüelles, MD, Department of Internal Medicine, Hospital Universitario Central de Asturias; N. Ortego-Centeno, MD, PhD, Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital Campus de la Salud, Complejo Universitario de Granada; L. Trapiella-Martínez, MD, PhD, Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital de Cabueñes; C. Carbonell-Muñoz, MD, Department of Internal Medicine, Complejo Asistencial Universitario de Salamanca; X. Pla-Salas, MD, Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Consorci Hospitalari de Vic; I. Perales-Fraile, MD, Department of Internal Medicine, Hospital Universitario Rey Juan Carlos; X. Corbella, MD, PhD, Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat, and Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya; V. Fonollosa-Pla, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron; C.P. Simeón Aznar, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron. Address correspondence to Dr. M. Pestaña-Fernández, Bellvitge University Hospital, Department of Internal Medicine, Feixa Llarga, s/n, 08907 L’Hospitalet de Llobregat, Barcelona, Spain. E-mail: Melani.Pestana@sanitatintegral.org. Accepted for publication January 25, 2019.
Mónica Rodríguez-Carballeira
From the Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat, Barcelona; Department of Internal Medicine, Corporación Sanitaria Universitaria Parc Taulí, Sabadell, Barcelona; Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron, Barcelona; Unit of Systemic Autoimmune Diseases and Thrombosis, Department of Internal Medicine, Complejo Hospitalario Universitario de Vigo, Vigo, Pontevedra; Department of Internal Medicine, Hospital Universitario Virgen de las Nieves, Granada; Department of Internal Medicine, Hospital Universitario y Politécnico La Fe, Valencia; Department of Internal Medicine, Hospital Universitario Mútua Terrassa, Terrassa, Barcelona; Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Clínico Universitario Lozano Blesa, Zaragoza; Department of Systemic Autoimmune Diseases, Clinical Institute of Medicine and Dermatology, Hospital Universitario Clinic, Barcelona; Department of Internal Medicine, Hospital Universitario Central de Asturias, Oviedo, Asturias; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital Campus de la Salud, Complejo Universitario de Granada, Granada; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital de Cabueñes, Gijón, Asturias; Department of Internal Medicine, Complejo Asistencial Universitario de Salamanca, Salamanca; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Consorci Hospitalari de Vic, Vic, Barcelona; Department of Internal Medicine, Hospital Universitario Rey Juan Carlos, Móstoles, Madrid; Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya, Barcelona, Spain. This project was possible thanks to an unrestricted educational scholarship granted by Laboratorios Actelion. M. Pestaña-Fernández, MD, Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat; M. Rubio-Rivas, MD, PhD, Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat; C. Tolosa-Vilella, MD, PhD, Department of Internal Medicine, Corporación Sanitaria Universitaria Parc Taulí; A. Guillén-Del-Castillo, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron; M. Freire, MD, PhD, Unit of Systemic Autoimmune Diseases and Thrombosis, Department of Internal Medicine, Complejo Hospitalario Universitario de Vigo; J.A. Vargas-Hitos, MD, PhD, Department of Internal Medicine, Hospital Universitario Virgen de las Nieves; J.A. Todolí-Parra, MD, Department of Internal Medicine, Hospital Universitario y Politécnico La Fe; M. Rodríguez Carballeira, MD, PhD, Department of Internal Medicine, Hospital Universitario Mútua Terrassa; A. Marín-Ballvé, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Clínico Universitario Lozano Blesa; G. Espinosa, MD, PhD, Department of Systemic Autoimmune Diseases, Clinical Institute of Medicine and Dermatology, Hospital Universitario Clinic; D. Colunga-Argüelles, MD, Department of Internal Medicine, Hospital Universitario Central de Asturias; N. Ortego-Centeno, MD, PhD, Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital Campus de la Salud, Complejo Universitario de Granada; L. Trapiella-Martínez, MD, PhD, Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital de Cabueñes; C. Carbonell-Muñoz, MD, Department of Internal Medicine, Complejo Asistencial Universitario de Salamanca; X. Pla-Salas, MD, Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Consorci Hospitalari de Vic; I. Perales-Fraile, MD, Department of Internal Medicine, Hospital Universitario Rey Juan Carlos; X. Corbella, MD, PhD, Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat, and Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya; V. Fonollosa-Pla, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron; C.P. Simeón Aznar, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron. Address correspondence to Dr. M. Pestaña-Fernández, Bellvitge University Hospital, Department of Internal Medicine, Feixa Llarga, s/n, 08907 L’Hospitalet de Llobregat, Barcelona, Spain. E-mail: Melani.Pestana@sanitatintegral.org. Accepted for publication January 25, 2019.
Adela Marín-Ballvé
From the Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat, Barcelona; Department of Internal Medicine, Corporación Sanitaria Universitaria Parc Taulí, Sabadell, Barcelona; Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron, Barcelona; Unit of Systemic Autoimmune Diseases and Thrombosis, Department of Internal Medicine, Complejo Hospitalario Universitario de Vigo, Vigo, Pontevedra; Department of Internal Medicine, Hospital Universitario Virgen de las Nieves, Granada; Department of Internal Medicine, Hospital Universitario y Politécnico La Fe, Valencia; Department of Internal Medicine, Hospital Universitario Mútua Terrassa, Terrassa, Barcelona; Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Clínico Universitario Lozano Blesa, Zaragoza; Department of Systemic Autoimmune Diseases, Clinical Institute of Medicine and Dermatology, Hospital Universitario Clinic, Barcelona; Department of Internal Medicine, Hospital Universitario Central de Asturias, Oviedo, Asturias; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital Campus de la Salud, Complejo Universitario de Granada, Granada; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital de Cabueñes, Gijón, Asturias; Department of Internal Medicine, Complejo Asistencial Universitario de Salamanca, Salamanca; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Consorci Hospitalari de Vic, Vic, Barcelona; Department of Internal Medicine, Hospital Universitario Rey Juan Carlos, Móstoles, Madrid; Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya, Barcelona, Spain. This project was possible thanks to an unrestricted educational scholarship granted by Laboratorios Actelion. M. Pestaña-Fernández, MD, Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat; M. Rubio-Rivas, MD, PhD, Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat; C. Tolosa-Vilella, MD, PhD, Department of Internal Medicine, Corporación Sanitaria Universitaria Parc Taulí; A. Guillén-Del-Castillo, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron; M. Freire, MD, PhD, Unit of Systemic Autoimmune Diseases and Thrombosis, Department of Internal Medicine, Complejo Hospitalario Universitario de Vigo; J.A. Vargas-Hitos, MD, PhD, Department of Internal Medicine, Hospital Universitario Virgen de las Nieves; J.A. Todolí-Parra, MD, Department of Internal Medicine, Hospital Universitario y Politécnico La Fe; M. Rodríguez Carballeira, MD, PhD, Department of Internal Medicine, Hospital Universitario Mútua Terrassa; A. Marín-Ballvé, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Clínico Universitario Lozano Blesa; G. Espinosa, MD, PhD, Department of Systemic Autoimmune Diseases, Clinical Institute of Medicine and Dermatology, Hospital Universitario Clinic; D. Colunga-Argüelles, MD, Department of Internal Medicine, Hospital Universitario Central de Asturias; N. Ortego-Centeno, MD, PhD, Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital Campus de la Salud, Complejo Universitario de Granada; L. Trapiella-Martínez, MD, PhD, Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital de Cabueñes; C. Carbonell-Muñoz, MD, Department of Internal Medicine, Complejo Asistencial Universitario de Salamanca; X. Pla-Salas, MD, Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Consorci Hospitalari de Vic; I. Perales-Fraile, MD, Department of Internal Medicine, Hospital Universitario Rey Juan Carlos; X. Corbella, MD, PhD, Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat, and Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya; V. Fonollosa-Pla, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron; C.P. Simeón Aznar, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron. Address correspondence to Dr. M. Pestaña-Fernández, Bellvitge University Hospital, Department of Internal Medicine, Feixa Llarga, s/n, 08907 L’Hospitalet de Llobregat, Barcelona, Spain. E-mail: Melani.Pestana@sanitatintegral.org. Accepted for publication January 25, 2019.
Gerard Espinosa
From the Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat, Barcelona; Department of Internal Medicine, Corporación Sanitaria Universitaria Parc Taulí, Sabadell, Barcelona; Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron, Barcelona; Unit of Systemic Autoimmune Diseases and Thrombosis, Department of Internal Medicine, Complejo Hospitalario Universitario de Vigo, Vigo, Pontevedra; Department of Internal Medicine, Hospital Universitario Virgen de las Nieves, Granada; Department of Internal Medicine, Hospital Universitario y Politécnico La Fe, Valencia; Department of Internal Medicine, Hospital Universitario Mútua Terrassa, Terrassa, Barcelona; Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Clínico Universitario Lozano Blesa, Zaragoza; Department of Systemic Autoimmune Diseases, Clinical Institute of Medicine and Dermatology, Hospital Universitario Clinic, Barcelona; Department of Internal Medicine, Hospital Universitario Central de Asturias, Oviedo, Asturias; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital Campus de la Salud, Complejo Universitario de Granada, Granada; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital de Cabueñes, Gijón, Asturias; Department of Internal Medicine, Complejo Asistencial Universitario de Salamanca, Salamanca; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Consorci Hospitalari de Vic, Vic, Barcelona; Department of Internal Medicine, Hospital Universitario Rey Juan Carlos, Móstoles, Madrid; Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya, Barcelona, Spain. This project was possible thanks to an unrestricted educational scholarship granted by Laboratorios Actelion. M. Pestaña-Fernández, MD, Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat; M. Rubio-Rivas, MD, PhD, Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat; C. Tolosa-Vilella, MD, PhD, Department of Internal Medicine, Corporación Sanitaria Universitaria Parc Taulí; A. Guillén-Del-Castillo, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron; M. Freire, MD, PhD, Unit of Systemic Autoimmune Diseases and Thrombosis, Department of Internal Medicine, Complejo Hospitalario Universitario de Vigo; J.A. Vargas-Hitos, MD, PhD, Department of Internal Medicine, Hospital Universitario Virgen de las Nieves; J.A. Todolí-Parra, MD, Department of Internal Medicine, Hospital Universitario y Politécnico La Fe; M. Rodríguez Carballeira, MD, PhD, Department of Internal Medicine, Hospital Universitario Mútua Terrassa; A. Marín-Ballvé, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Clínico Universitario Lozano Blesa; G. Espinosa, MD, PhD, Department of Systemic Autoimmune Diseases, Clinical Institute of Medicine and Dermatology, Hospital Universitario Clinic; D. Colunga-Argüelles, MD, Department of Internal Medicine, Hospital Universitario Central de Asturias; N. Ortego-Centeno, MD, PhD, Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital Campus de la Salud, Complejo Universitario de Granada; L. Trapiella-Martínez, MD, PhD, Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital de Cabueñes; C. Carbonell-Muñoz, MD, Department of Internal Medicine, Complejo Asistencial Universitario de Salamanca; X. Pla-Salas, MD, Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Consorci Hospitalari de Vic; I. Perales-Fraile, MD, Department of Internal Medicine, Hospital Universitario Rey Juan Carlos; X. Corbella, MD, PhD, Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat, and Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya; V. Fonollosa-Pla, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron; C.P. Simeón Aznar, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron. Address correspondence to Dr. M. Pestaña-Fernández, Bellvitge University Hospital, Department of Internal Medicine, Feixa Llarga, s/n, 08907 L’Hospitalet de Llobregat, Barcelona, Spain. E-mail: Melani.Pestana@sanitatintegral.org. Accepted for publication January 25, 2019.
Dolores Colunga-Argüelles
From the Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat, Barcelona; Department of Internal Medicine, Corporación Sanitaria Universitaria Parc Taulí, Sabadell, Barcelona; Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron, Barcelona; Unit of Systemic Autoimmune Diseases and Thrombosis, Department of Internal Medicine, Complejo Hospitalario Universitario de Vigo, Vigo, Pontevedra; Department of Internal Medicine, Hospital Universitario Virgen de las Nieves, Granada; Department of Internal Medicine, Hospital Universitario y Politécnico La Fe, Valencia; Department of Internal Medicine, Hospital Universitario Mútua Terrassa, Terrassa, Barcelona; Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Clínico Universitario Lozano Blesa, Zaragoza; Department of Systemic Autoimmune Diseases, Clinical Institute of Medicine and Dermatology, Hospital Universitario Clinic, Barcelona; Department of Internal Medicine, Hospital Universitario Central de Asturias, Oviedo, Asturias; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital Campus de la Salud, Complejo Universitario de Granada, Granada; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital de Cabueñes, Gijón, Asturias; Department of Internal Medicine, Complejo Asistencial Universitario de Salamanca, Salamanca; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Consorci Hospitalari de Vic, Vic, Barcelona; Department of Internal Medicine, Hospital Universitario Rey Juan Carlos, Móstoles, Madrid; Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya, Barcelona, Spain. This project was possible thanks to an unrestricted educational scholarship granted by Laboratorios Actelion. M. Pestaña-Fernández, MD, Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat; M. Rubio-Rivas, MD, PhD, Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat; C. Tolosa-Vilella, MD, PhD, Department of Internal Medicine, Corporación Sanitaria Universitaria Parc Taulí; A. Guillén-Del-Castillo, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron; M. Freire, MD, PhD, Unit of Systemic Autoimmune Diseases and Thrombosis, Department of Internal Medicine, Complejo Hospitalario Universitario de Vigo; J.A. Vargas-Hitos, MD, PhD, Department of Internal Medicine, Hospital Universitario Virgen de las Nieves; J.A. Todolí-Parra, MD, Department of Internal Medicine, Hospital Universitario y Politécnico La Fe; M. Rodríguez Carballeira, MD, PhD, Department of Internal Medicine, Hospital Universitario Mútua Terrassa; A. Marín-Ballvé, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Clínico Universitario Lozano Blesa; G. Espinosa, MD, PhD, Department of Systemic Autoimmune Diseases, Clinical Institute of Medicine and Dermatology, Hospital Universitario Clinic; D. Colunga-Argüelles, MD, Department of Internal Medicine, Hospital Universitario Central de Asturias; N. Ortego-Centeno, MD, PhD, Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital Campus de la Salud, Complejo Universitario de Granada; L. Trapiella-Martínez, MD, PhD, Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital de Cabueñes; C. Carbonell-Muñoz, MD, Department of Internal Medicine, Complejo Asistencial Universitario de Salamanca; X. Pla-Salas, MD, Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Consorci Hospitalari de Vic; I. Perales-Fraile, MD, Department of Internal Medicine, Hospital Universitario Rey Juan Carlos; X. Corbella, MD, PhD, Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat, and Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya; V. Fonollosa-Pla, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron; C.P. Simeón Aznar, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron. Address correspondence to Dr. M. Pestaña-Fernández, Bellvitge University Hospital, Department of Internal Medicine, Feixa Llarga, s/n, 08907 L’Hospitalet de Llobregat, Barcelona, Spain. E-mail: Melani.Pestana@sanitatintegral.org. Accepted for publication January 25, 2019.
Norberto Ortego-Centeno
From the Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat, Barcelona; Department of Internal Medicine, Corporación Sanitaria Universitaria Parc Taulí, Sabadell, Barcelona; Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron, Barcelona; Unit of Systemic Autoimmune Diseases and Thrombosis, Department of Internal Medicine, Complejo Hospitalario Universitario de Vigo, Vigo, Pontevedra; Department of Internal Medicine, Hospital Universitario Virgen de las Nieves, Granada; Department of Internal Medicine, Hospital Universitario y Politécnico La Fe, Valencia; Department of Internal Medicine, Hospital Universitario Mútua Terrassa, Terrassa, Barcelona; Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Clínico Universitario Lozano Blesa, Zaragoza; Department of Systemic Autoimmune Diseases, Clinical Institute of Medicine and Dermatology, Hospital Universitario Clinic, Barcelona; Department of Internal Medicine, Hospital Universitario Central de Asturias, Oviedo, Asturias; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital Campus de la Salud, Complejo Universitario de Granada, Granada; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital de Cabueñes, Gijón, Asturias; Department of Internal Medicine, Complejo Asistencial Universitario de Salamanca, Salamanca; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Consorci Hospitalari de Vic, Vic, Barcelona; Department of Internal Medicine, Hospital Universitario Rey Juan Carlos, Móstoles, Madrid; Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya, Barcelona, Spain. This project was possible thanks to an unrestricted educational scholarship granted by Laboratorios Actelion. M. Pestaña-Fernández, MD, Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat; M. Rubio-Rivas, MD, PhD, Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat; C. Tolosa-Vilella, MD, PhD, Department of Internal Medicine, Corporación Sanitaria Universitaria Parc Taulí; A. Guillén-Del-Castillo, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron; M. Freire, MD, PhD, Unit of Systemic Autoimmune Diseases and Thrombosis, Department of Internal Medicine, Complejo Hospitalario Universitario de Vigo; J.A. Vargas-Hitos, MD, PhD, Department of Internal Medicine, Hospital Universitario Virgen de las Nieves; J.A. Todolí-Parra, MD, Department of Internal Medicine, Hospital Universitario y Politécnico La Fe; M. Rodríguez Carballeira, MD, PhD, Department of Internal Medicine, Hospital Universitario Mútua Terrassa; A. Marín-Ballvé, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Clínico Universitario Lozano Blesa; G. Espinosa, MD, PhD, Department of Systemic Autoimmune Diseases, Clinical Institute of Medicine and Dermatology, Hospital Universitario Clinic; D. Colunga-Argüelles, MD, Department of Internal Medicine, Hospital Universitario Central de Asturias; N. Ortego-Centeno, MD, PhD, Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital Campus de la Salud, Complejo Universitario de Granada; L. Trapiella-Martínez, MD, PhD, Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital de Cabueñes; C. Carbonell-Muñoz, MD, Department of Internal Medicine, Complejo Asistencial Universitario de Salamanca; X. Pla-Salas, MD, Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Consorci Hospitalari de Vic; I. Perales-Fraile, MD, Department of Internal Medicine, Hospital Universitario Rey Juan Carlos; X. Corbella, MD, PhD, Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat, and Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya; V. Fonollosa-Pla, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron; C.P. Simeón Aznar, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron. Address correspondence to Dr. M. Pestaña-Fernández, Bellvitge University Hospital, Department of Internal Medicine, Feixa Llarga, s/n, 08907 L’Hospitalet de Llobregat, Barcelona, Spain. E-mail: Melani.Pestana@sanitatintegral.org. Accepted for publication January 25, 2019.
Luis Trapiella-Martínez
From the Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat, Barcelona; Department of Internal Medicine, Corporación Sanitaria Universitaria Parc Taulí, Sabadell, Barcelona; Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron, Barcelona; Unit of Systemic Autoimmune Diseases and Thrombosis, Department of Internal Medicine, Complejo Hospitalario Universitario de Vigo, Vigo, Pontevedra; Department of Internal Medicine, Hospital Universitario Virgen de las Nieves, Granada; Department of Internal Medicine, Hospital Universitario y Politécnico La Fe, Valencia; Department of Internal Medicine, Hospital Universitario Mútua Terrassa, Terrassa, Barcelona; Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Clínico Universitario Lozano Blesa, Zaragoza; Department of Systemic Autoimmune Diseases, Clinical Institute of Medicine and Dermatology, Hospital Universitario Clinic, Barcelona; Department of Internal Medicine, Hospital Universitario Central de Asturias, Oviedo, Asturias; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital Campus de la Salud, Complejo Universitario de Granada, Granada; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital de Cabueñes, Gijón, Asturias; Department of Internal Medicine, Complejo Asistencial Universitario de Salamanca, Salamanca; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Consorci Hospitalari de Vic, Vic, Barcelona; Department of Internal Medicine, Hospital Universitario Rey Juan Carlos, Móstoles, Madrid; Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya, Barcelona, Spain. This project was possible thanks to an unrestricted educational scholarship granted by Laboratorios Actelion. M. Pestaña-Fernández, MD, Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat; M. Rubio-Rivas, MD, PhD, Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat; C. Tolosa-Vilella, MD, PhD, Department of Internal Medicine, Corporación Sanitaria Universitaria Parc Taulí; A. Guillén-Del-Castillo, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron; M. Freire, MD, PhD, Unit of Systemic Autoimmune Diseases and Thrombosis, Department of Internal Medicine, Complejo Hospitalario Universitario de Vigo; J.A. Vargas-Hitos, MD, PhD, Department of Internal Medicine, Hospital Universitario Virgen de las Nieves; J.A. Todolí-Parra, MD, Department of Internal Medicine, Hospital Universitario y Politécnico La Fe; M. Rodríguez Carballeira, MD, PhD, Department of Internal Medicine, Hospital Universitario Mútua Terrassa; A. Marín-Ballvé, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Clínico Universitario Lozano Blesa; G. Espinosa, MD, PhD, Department of Systemic Autoimmune Diseases, Clinical Institute of Medicine and Dermatology, Hospital Universitario Clinic; D. Colunga-Argüelles, MD, Department of Internal Medicine, Hospital Universitario Central de Asturias; N. Ortego-Centeno, MD, PhD, Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital Campus de la Salud, Complejo Universitario de Granada; L. Trapiella-Martínez, MD, PhD, Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital de Cabueñes; C. Carbonell-Muñoz, MD, Department of Internal Medicine, Complejo Asistencial Universitario de Salamanca; X. Pla-Salas, MD, Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Consorci Hospitalari de Vic; I. Perales-Fraile, MD, Department of Internal Medicine, Hospital Universitario Rey Juan Carlos; X. Corbella, MD, PhD, Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat, and Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya; V. Fonollosa-Pla, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron; C.P. Simeón Aznar, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron. Address correspondence to Dr. M. Pestaña-Fernández, Bellvitge University Hospital, Department of Internal Medicine, Feixa Llarga, s/n, 08907 L’Hospitalet de Llobregat, Barcelona, Spain. E-mail: Melani.Pestana@sanitatintegral.org. Accepted for publication January 25, 2019.
Cristina Carbonell-Muñoz
From the Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat, Barcelona; Department of Internal Medicine, Corporación Sanitaria Universitaria Parc Taulí, Sabadell, Barcelona; Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron, Barcelona; Unit of Systemic Autoimmune Diseases and Thrombosis, Department of Internal Medicine, Complejo Hospitalario Universitario de Vigo, Vigo, Pontevedra; Department of Internal Medicine, Hospital Universitario Virgen de las Nieves, Granada; Department of Internal Medicine, Hospital Universitario y Politécnico La Fe, Valencia; Department of Internal Medicine, Hospital Universitario Mútua Terrassa, Terrassa, Barcelona; Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Clínico Universitario Lozano Blesa, Zaragoza; Department of Systemic Autoimmune Diseases, Clinical Institute of Medicine and Dermatology, Hospital Universitario Clinic, Barcelona; Department of Internal Medicine, Hospital Universitario Central de Asturias, Oviedo, Asturias; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital Campus de la Salud, Complejo Universitario de Granada, Granada; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital de Cabueñes, Gijón, Asturias; Department of Internal Medicine, Complejo Asistencial Universitario de Salamanca, Salamanca; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Consorci Hospitalari de Vic, Vic, Barcelona; Department of Internal Medicine, Hospital Universitario Rey Juan Carlos, Móstoles, Madrid; Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya, Barcelona, Spain. This project was possible thanks to an unrestricted educational scholarship granted by Laboratorios Actelion. M. Pestaña-Fernández, MD, Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat; M. Rubio-Rivas, MD, PhD, Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat; C. Tolosa-Vilella, MD, PhD, Department of Internal Medicine, Corporación Sanitaria Universitaria Parc Taulí; A. Guillén-Del-Castillo, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron; M. Freire, MD, PhD, Unit of Systemic Autoimmune Diseases and Thrombosis, Department of Internal Medicine, Complejo Hospitalario Universitario de Vigo; J.A. Vargas-Hitos, MD, PhD, Department of Internal Medicine, Hospital Universitario Virgen de las Nieves; J.A. Todolí-Parra, MD, Department of Internal Medicine, Hospital Universitario y Politécnico La Fe; M. Rodríguez Carballeira, MD, PhD, Department of Internal Medicine, Hospital Universitario Mútua Terrassa; A. Marín-Ballvé, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Clínico Universitario Lozano Blesa; G. Espinosa, MD, PhD, Department of Systemic Autoimmune Diseases, Clinical Institute of Medicine and Dermatology, Hospital Universitario Clinic; D. Colunga-Argüelles, MD, Department of Internal Medicine, Hospital Universitario Central de Asturias; N. Ortego-Centeno, MD, PhD, Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital Campus de la Salud, Complejo Universitario de Granada; L. Trapiella-Martínez, MD, PhD, Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital de Cabueñes; C. Carbonell-Muñoz, MD, Department of Internal Medicine, Complejo Asistencial Universitario de Salamanca; X. Pla-Salas, MD, Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Consorci Hospitalari de Vic; I. Perales-Fraile, MD, Department of Internal Medicine, Hospital Universitario Rey Juan Carlos; X. Corbella, MD, PhD, Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat, and Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya; V. Fonollosa-Pla, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron; C.P. Simeón Aznar, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron. Address correspondence to Dr. M. Pestaña-Fernández, Bellvitge University Hospital, Department of Internal Medicine, Feixa Llarga, s/n, 08907 L’Hospitalet de Llobregat, Barcelona, Spain. E-mail: Melani.Pestana@sanitatintegral.org. Accepted for publication January 25, 2019.
Xavier Pla-Salas
From the Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat, Barcelona; Department of Internal Medicine, Corporación Sanitaria Universitaria Parc Taulí, Sabadell, Barcelona; Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron, Barcelona; Unit of Systemic Autoimmune Diseases and Thrombosis, Department of Internal Medicine, Complejo Hospitalario Universitario de Vigo, Vigo, Pontevedra; Department of Internal Medicine, Hospital Universitario Virgen de las Nieves, Granada; Department of Internal Medicine, Hospital Universitario y Politécnico La Fe, Valencia; Department of Internal Medicine, Hospital Universitario Mútua Terrassa, Terrassa, Barcelona; Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Clínico Universitario Lozano Blesa, Zaragoza; Department of Systemic Autoimmune Diseases, Clinical Institute of Medicine and Dermatology, Hospital Universitario Clinic, Barcelona; Department of Internal Medicine, Hospital Universitario Central de Asturias, Oviedo, Asturias; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital Campus de la Salud, Complejo Universitario de Granada, Granada; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital de Cabueñes, Gijón, Asturias; Department of Internal Medicine, Complejo Asistencial Universitario de Salamanca, Salamanca; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Consorci Hospitalari de Vic, Vic, Barcelona; Department of Internal Medicine, Hospital Universitario Rey Juan Carlos, Móstoles, Madrid; Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya, Barcelona, Spain. This project was possible thanks to an unrestricted educational scholarship granted by Laboratorios Actelion. M. Pestaña-Fernández, MD, Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat; M. Rubio-Rivas, MD, PhD, Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat; C. Tolosa-Vilella, MD, PhD, Department of Internal Medicine, Corporación Sanitaria Universitaria Parc Taulí; A. Guillén-Del-Castillo, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron; M. Freire, MD, PhD, Unit of Systemic Autoimmune Diseases and Thrombosis, Department of Internal Medicine, Complejo Hospitalario Universitario de Vigo; J.A. Vargas-Hitos, MD, PhD, Department of Internal Medicine, Hospital Universitario Virgen de las Nieves; J.A. Todolí-Parra, MD, Department of Internal Medicine, Hospital Universitario y Politécnico La Fe; M. Rodríguez Carballeira, MD, PhD, Department of Internal Medicine, Hospital Universitario Mútua Terrassa; A. Marín-Ballvé, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Clínico Universitario Lozano Blesa; G. Espinosa, MD, PhD, Department of Systemic Autoimmune Diseases, Clinical Institute of Medicine and Dermatology, Hospital Universitario Clinic; D. Colunga-Argüelles, MD, Department of Internal Medicine, Hospital Universitario Central de Asturias; N. Ortego-Centeno, MD, PhD, Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital Campus de la Salud, Complejo Universitario de Granada; L. Trapiella-Martínez, MD, PhD, Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital de Cabueñes; C. Carbonell-Muñoz, MD, Department of Internal Medicine, Complejo Asistencial Universitario de Salamanca; X. Pla-Salas, MD, Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Consorci Hospitalari de Vic; I. Perales-Fraile, MD, Department of Internal Medicine, Hospital Universitario Rey Juan Carlos; X. Corbella, MD, PhD, Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat, and Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya; V. Fonollosa-Pla, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron; C.P. Simeón Aznar, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron. Address correspondence to Dr. M. Pestaña-Fernández, Bellvitge University Hospital, Department of Internal Medicine, Feixa Llarga, s/n, 08907 L’Hospitalet de Llobregat, Barcelona, Spain. E-mail: Melani.Pestana@sanitatintegral.org. Accepted for publication January 25, 2019.
Isabel Perales-Fraile
From the Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat, Barcelona; Department of Internal Medicine, Corporación Sanitaria Universitaria Parc Taulí, Sabadell, Barcelona; Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron, Barcelona; Unit of Systemic Autoimmune Diseases and Thrombosis, Department of Internal Medicine, Complejo Hospitalario Universitario de Vigo, Vigo, Pontevedra; Department of Internal Medicine, Hospital Universitario Virgen de las Nieves, Granada; Department of Internal Medicine, Hospital Universitario y Politécnico La Fe, Valencia; Department of Internal Medicine, Hospital Universitario Mútua Terrassa, Terrassa, Barcelona; Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Clínico Universitario Lozano Blesa, Zaragoza; Department of Systemic Autoimmune Diseases, Clinical Institute of Medicine and Dermatology, Hospital Universitario Clinic, Barcelona; Department of Internal Medicine, Hospital Universitario Central de Asturias, Oviedo, Asturias; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital Campus de la Salud, Complejo Universitario de Granada, Granada; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital de Cabueñes, Gijón, Asturias; Department of Internal Medicine, Complejo Asistencial Universitario de Salamanca, Salamanca; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Consorci Hospitalari de Vic, Vic, Barcelona; Department of Internal Medicine, Hospital Universitario Rey Juan Carlos, Móstoles, Madrid; Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya, Barcelona, Spain. This project was possible thanks to an unrestricted educational scholarship granted by Laboratorios Actelion. M. Pestaña-Fernández, MD, Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat; M. Rubio-Rivas, MD, PhD, Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat; C. Tolosa-Vilella, MD, PhD, Department of Internal Medicine, Corporación Sanitaria Universitaria Parc Taulí; A. Guillén-Del-Castillo, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron; M. Freire, MD, PhD, Unit of Systemic Autoimmune Diseases and Thrombosis, Department of Internal Medicine, Complejo Hospitalario Universitario de Vigo; J.A. Vargas-Hitos, MD, PhD, Department of Internal Medicine, Hospital Universitario Virgen de las Nieves; J.A. Todolí-Parra, MD, Department of Internal Medicine, Hospital Universitario y Politécnico La Fe; M. Rodríguez Carballeira, MD, PhD, Department of Internal Medicine, Hospital Universitario Mútua Terrassa; A. Marín-Ballvé, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Clínico Universitario Lozano Blesa; G. Espinosa, MD, PhD, Department of Systemic Autoimmune Diseases, Clinical Institute of Medicine and Dermatology, Hospital Universitario Clinic; D. Colunga-Argüelles, MD, Department of Internal Medicine, Hospital Universitario Central de Asturias; N. Ortego-Centeno, MD, PhD, Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital Campus de la Salud, Complejo Universitario de Granada; L. Trapiella-Martínez, MD, PhD, Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital de Cabueñes; C. Carbonell-Muñoz, MD, Department of Internal Medicine, Complejo Asistencial Universitario de Salamanca; X. Pla-Salas, MD, Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Consorci Hospitalari de Vic; I. Perales-Fraile, MD, Department of Internal Medicine, Hospital Universitario Rey Juan Carlos; X. Corbella, MD, PhD, Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat, and Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya; V. Fonollosa-Pla, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron; C.P. Simeón Aznar, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron. Address correspondence to Dr. M. Pestaña-Fernández, Bellvitge University Hospital, Department of Internal Medicine, Feixa Llarga, s/n, 08907 L’Hospitalet de Llobregat, Barcelona, Spain. E-mail: Melani.Pestana@sanitatintegral.org. Accepted for publication January 25, 2019.
Xavier Corbella
From the Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat, Barcelona; Department of Internal Medicine, Corporación Sanitaria Universitaria Parc Taulí, Sabadell, Barcelona; Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron, Barcelona; Unit of Systemic Autoimmune Diseases and Thrombosis, Department of Internal Medicine, Complejo Hospitalario Universitario de Vigo, Vigo, Pontevedra; Department of Internal Medicine, Hospital Universitario Virgen de las Nieves, Granada; Department of Internal Medicine, Hospital Universitario y Politécnico La Fe, Valencia; Department of Internal Medicine, Hospital Universitario Mútua Terrassa, Terrassa, Barcelona; Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Clínico Universitario Lozano Blesa, Zaragoza; Department of Systemic Autoimmune Diseases, Clinical Institute of Medicine and Dermatology, Hospital Universitario Clinic, Barcelona; Department of Internal Medicine, Hospital Universitario Central de Asturias, Oviedo, Asturias; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital Campus de la Salud, Complejo Universitario de Granada, Granada; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital de Cabueñes, Gijón, Asturias; Department of Internal Medicine, Complejo Asistencial Universitario de Salamanca, Salamanca; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Consorci Hospitalari de Vic, Vic, Barcelona; Department of Internal Medicine, Hospital Universitario Rey Juan Carlos, Móstoles, Madrid; Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya, Barcelona, Spain. This project was possible thanks to an unrestricted educational scholarship granted by Laboratorios Actelion. M. Pestaña-Fernández, MD, Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat; M. Rubio-Rivas, MD, PhD, Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat; C. Tolosa-Vilella, MD, PhD, Department of Internal Medicine, Corporación Sanitaria Universitaria Parc Taulí; A. Guillén-Del-Castillo, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron; M. Freire, MD, PhD, Unit of Systemic Autoimmune Diseases and Thrombosis, Department of Internal Medicine, Complejo Hospitalario Universitario de Vigo; J.A. Vargas-Hitos, MD, PhD, Department of Internal Medicine, Hospital Universitario Virgen de las Nieves; J.A. Todolí-Parra, MD, Department of Internal Medicine, Hospital Universitario y Politécnico La Fe; M. Rodríguez Carballeira, MD, PhD, Department of Internal Medicine, Hospital Universitario Mútua Terrassa; A. Marín-Ballvé, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Clínico Universitario Lozano Blesa; G. Espinosa, MD, PhD, Department of Systemic Autoimmune Diseases, Clinical Institute of Medicine and Dermatology, Hospital Universitario Clinic; D. Colunga-Argüelles, MD, Department of Internal Medicine, Hospital Universitario Central de Asturias; N. Ortego-Centeno, MD, PhD, Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital Campus de la Salud, Complejo Universitario de Granada; L. Trapiella-Martínez, MD, PhD, Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital de Cabueñes; C. Carbonell-Muñoz, MD, Department of Internal Medicine, Complejo Asistencial Universitario de Salamanca; X. Pla-Salas, MD, Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Consorci Hospitalari de Vic; I. Perales-Fraile, MD, Department of Internal Medicine, Hospital Universitario Rey Juan Carlos; X. Corbella, MD, PhD, Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat, and Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya; V. Fonollosa-Pla, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron; C.P. Simeón Aznar, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron. Address correspondence to Dr. M. Pestaña-Fernández, Bellvitge University Hospital, Department of Internal Medicine, Feixa Llarga, s/n, 08907 L’Hospitalet de Llobregat, Barcelona, Spain. E-mail: Melani.Pestana@sanitatintegral.org. Accepted for publication January 25, 2019.
Vicent Fonollosa-Pla
From the Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat, Barcelona; Department of Internal Medicine, Corporación Sanitaria Universitaria Parc Taulí, Sabadell, Barcelona; Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron, Barcelona; Unit of Systemic Autoimmune Diseases and Thrombosis, Department of Internal Medicine, Complejo Hospitalario Universitario de Vigo, Vigo, Pontevedra; Department of Internal Medicine, Hospital Universitario Virgen de las Nieves, Granada; Department of Internal Medicine, Hospital Universitario y Politécnico La Fe, Valencia; Department of Internal Medicine, Hospital Universitario Mútua Terrassa, Terrassa, Barcelona; Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Clínico Universitario Lozano Blesa, Zaragoza; Department of Systemic Autoimmune Diseases, Clinical Institute of Medicine and Dermatology, Hospital Universitario Clinic, Barcelona; Department of Internal Medicine, Hospital Universitario Central de Asturias, Oviedo, Asturias; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital Campus de la Salud, Complejo Universitario de Granada, Granada; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital de Cabueñes, Gijón, Asturias; Department of Internal Medicine, Complejo Asistencial Universitario de Salamanca, Salamanca; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Consorci Hospitalari de Vic, Vic, Barcelona; Department of Internal Medicine, Hospital Universitario Rey Juan Carlos, Móstoles, Madrid; Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya, Barcelona, Spain. This project was possible thanks to an unrestricted educational scholarship granted by Laboratorios Actelion. M. Pestaña-Fernández, MD, Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat; M. Rubio-Rivas, MD, PhD, Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat; C. Tolosa-Vilella, MD, PhD, Department of Internal Medicine, Corporación Sanitaria Universitaria Parc Taulí; A. Guillén-Del-Castillo, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron; M. Freire, MD, PhD, Unit of Systemic Autoimmune Diseases and Thrombosis, Department of Internal Medicine, Complejo Hospitalario Universitario de Vigo; J.A. Vargas-Hitos, MD, PhD, Department of Internal Medicine, Hospital Universitario Virgen de las Nieves; J.A. Todolí-Parra, MD, Department of Internal Medicine, Hospital Universitario y Politécnico La Fe; M. Rodríguez Carballeira, MD, PhD, Department of Internal Medicine, Hospital Universitario Mútua Terrassa; A. Marín-Ballvé, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Clínico Universitario Lozano Blesa; G. Espinosa, MD, PhD, Department of Systemic Autoimmune Diseases, Clinical Institute of Medicine and Dermatology, Hospital Universitario Clinic; D. Colunga-Argüelles, MD, Department of Internal Medicine, Hospital Universitario Central de Asturias; N. Ortego-Centeno, MD, PhD, Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital Campus de la Salud, Complejo Universitario de Granada; L. Trapiella-Martínez, MD, PhD, Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital de Cabueñes; C. Carbonell-Muñoz, MD, Department of Internal Medicine, Complejo Asistencial Universitario de Salamanca; X. Pla-Salas, MD, Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Consorci Hospitalari de Vic; I. Perales-Fraile, MD, Department of Internal Medicine, Hospital Universitario Rey Juan Carlos; X. Corbella, MD, PhD, Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat, and Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya; V. Fonollosa-Pla, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron; C.P. Simeón Aznar, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron. Address correspondence to Dr. M. Pestaña-Fernández, Bellvitge University Hospital, Department of Internal Medicine, Feixa Llarga, s/n, 08907 L’Hospitalet de Llobregat, Barcelona, Spain. E-mail: Melani.Pestana@sanitatintegral.org. Accepted for publication January 25, 2019.
Carmen Pilar Simeón-Aznar
From the Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat, Barcelona; Department of Internal Medicine, Corporación Sanitaria Universitaria Parc Taulí, Sabadell, Barcelona; Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron, Barcelona; Unit of Systemic Autoimmune Diseases and Thrombosis, Department of Internal Medicine, Complejo Hospitalario Universitario de Vigo, Vigo, Pontevedra; Department of Internal Medicine, Hospital Universitario Virgen de las Nieves, Granada; Department of Internal Medicine, Hospital Universitario y Politécnico La Fe, Valencia; Department of Internal Medicine, Hospital Universitario Mútua Terrassa, Terrassa, Barcelona; Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Clínico Universitario Lozano Blesa, Zaragoza; Department of Systemic Autoimmune Diseases, Clinical Institute of Medicine and Dermatology, Hospital Universitario Clinic, Barcelona; Department of Internal Medicine, Hospital Universitario Central de Asturias, Oviedo, Asturias; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital Campus de la Salud, Complejo Universitario de Granada, Granada; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital de Cabueñes, Gijón, Asturias; Department of Internal Medicine, Complejo Asistencial Universitario de Salamanca, Salamanca; Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Consorci Hospitalari de Vic, Vic, Barcelona; Department of Internal Medicine, Hospital Universitario Rey Juan Carlos, Móstoles, Madrid; Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya, Barcelona, Spain. This project was possible thanks to an unrestricted educational scholarship granted by Laboratorios Actelion. M. Pestaña-Fernández, MD, Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat; M. Rubio-Rivas, MD, PhD, Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat; C. Tolosa-Vilella, MD, PhD, Department of Internal Medicine, Corporación Sanitaria Universitaria Parc Taulí; A. Guillén-Del-Castillo, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron; M. Freire, MD, PhD, Unit of Systemic Autoimmune Diseases and Thrombosis, Department of Internal Medicine, Complejo Hospitalario Universitario de Vigo; J.A. Vargas-Hitos, MD, PhD, Department of Internal Medicine, Hospital Universitario Virgen de las Nieves; J.A. Todolí-Parra, MD, Department of Internal Medicine, Hospital Universitario y Politécnico La Fe; M. Rodríguez Carballeira, MD, PhD, Department of Internal Medicine, Hospital Universitario Mútua Terrassa; A. Marín-Ballvé, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Clínico Universitario Lozano Blesa; G. Espinosa, MD, PhD, Department of Systemic Autoimmune Diseases, Clinical Institute of Medicine and Dermatology, Hospital Universitario Clinic; D. Colunga-Argüelles, MD, Department of Internal Medicine, Hospital Universitario Central de Asturias; N. Ortego-Centeno, MD, PhD, Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital Campus de la Salud, Complejo Universitario de Granada; L. Trapiella-Martínez, MD, PhD, Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Hospital de Cabueñes; C. Carbonell-Muñoz, MD, Department of Internal Medicine, Complejo Asistencial Universitario de Salamanca; X. Pla-Salas, MD, Unit of Systemic Autoimmune Diseases, Department of Internal Medicine, Consorci Hospitalari de Vic; I. Perales-Fraile, MD, Department of Internal Medicine, Hospital Universitario Rey Juan Carlos; X. Corbella, MD, PhD, Autoimmune Diseases Unit, Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat, and Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya; V. Fonollosa-Pla, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron; C.P. Simeón Aznar, MD, PhD, Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d’Hebron. Address correspondence to Dr. M. Pestaña-Fernández, Bellvitge University Hospital, Department of Internal Medicine, Feixa Llarga, s/n, 08907 L’Hospitalet de Llobregat, Barcelona, Spain. E-mail: Melani.Pestana@sanitatintegral.org. Accepted for publication January 25, 2019.
In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Longterm Efficacy and Safety of Monotherapy versus Combination Therapy in Systemic Sclerosis–associated Pulmonary Arterial Hypertension: A Retrospective RESCLE Registry Study
Melani Pestaña-Fernández, Manuel Rubio-Rivas, Carles Tolosa-Vilella, Alfredo Guillén-Del-Castillo, Mayka Freire, Jose Antonio Vargas-Hitos, Jose Antonio Todolí-Parra, Mónica Rodríguez-Carballeira, Adela Marín-Ballvé, Gerard Espinosa, Dolores Colunga-Argüelles, Norberto Ortego-Centeno, Luis Trapiella-Martínez, Cristina Carbonell-Muñoz, Xavier Pla-Salas, Isabel Perales-Fraile, Xavier Corbella, Vicent Fonollosa-Pla, Carmen Pilar Simeón-Aznar
The Journal of Rheumatology Feb 2019, jrheum.180595; DOI: 10.3899/jrheum.180595
Longterm Efficacy and Safety of Monotherapy versus Combination Therapy in Systemic Sclerosis–associated Pulmonary Arterial Hypertension: A Retrospective RESCLE Registry Study
Melani Pestaña-Fernández, Manuel Rubio-Rivas, Carles Tolosa-Vilella, Alfredo Guillén-Del-Castillo, Mayka Freire, Jose Antonio Vargas-Hitos, Jose Antonio Todolí-Parra, Mónica Rodríguez-Carballeira, Adela Marín-Ballvé, Gerard Espinosa, Dolores Colunga-Argüelles, Norberto Ortego-Centeno, Luis Trapiella-Martínez, Cristina Carbonell-Muñoz, Xavier Pla-Salas, Isabel Perales-Fraile, Xavier Corbella, Vicent Fonollosa-Pla, Carmen Pilar Simeón-Aznar
The Journal of Rheumatology Feb 2019, jrheum.180595; DOI: 10.3899/jrheum.180595