Research ArticleArticle
Endorsement of the 66/68 Joint Count for the Measurement of Musculoskeletal Disease Activity: OMERACT 2018 Psoriatic Arthritis Workshop Report
Alí Duarte-García, Ying Ying Leung, Laura C. Coates, Dorcas Beaton, Robin Christensen, Ethan T. Craig, Maarten de Wit, Lihi Eder, Lara Fallon, Oliver FitzGerald, Dafna D. Gladman, Niti Goel, Richard Holland, Chris Lindsay, Lara Maxwell, Philip Mease, Ana Maria Orbai, Beverley Shea, Vibeke Strand, Douglas J. Veale, William Tillett and Alexis Ogdie
The Journal of Rheumatology February 2019, jrheum.181089; DOI: https://doi.org/10.3899/jrheum.181089
Alí Duarte-García
From the Division of Rheumatology, Department of Medicine, and the Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, Minnesota; Division of Rheumatology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Rheumatology, Duke University School of Medicine, Durham, North Carolina; Kezar Life Sciences, South San Francisco; Amgen Inc., Thousand Oaks, California; Swedish-Providence- St. John’s Health Systems and University of Washington, Seattle, Washington; Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Department of Rheumatology and Immunology, Singapore General Hospital, Singapore, Singapore; University of Leeds, Leeds; University of Oxford, Oxford; Royal National Hospital for Rheumatic Diseases; University of Bath, Bath, UK; Musculoskeletal Health and Outcomes Research, St. Michael’s Hospital; Institute for Work and Health; Department of Occupational Science and Occupational Therapy, Rehabilitation Sciences Institute and the Institute for Health Policy Management and Evaluation, University of Toronto; Department of Medicine, University of Toronto, Women’s College Hospital; Department of Medicine, University of Toronto, Toronto Western Hospital, Toronto; Cochrane Musculoskeletal Group, Ottawa Hospital Research Institute, Centre for Practice-Changing Research; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario; Pfizer Inc., Montreal, Quebec, Canada; Musculoskeletal Statistics Unit: The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen; Department of Rheumatology, Odense University Hospital, Odense, Denmark; Department of Medical Humanities, Patient Research Partner, Amsterdam University Medical Centre, Amsterdam, the Netherlands; Department of Rheumatology, St. Vincent’s University Hospital; Conway Institute for Biomolecular Research, University College Dublin, Ireland; Royal Prince Alfred Hospital Medical Centre, Sydney, Australia. Several parts of this study were funded by the Rheumatology Research Foundation Innovative Research Award (PI Ogdie) and some by R01- AR072363 (PI Ogdie). The Parker Institute, Bispebjerg and Frederiksberg Hospital (RC) is supported by a core grant from the Oak Foundation (OCAY-13-309). A.M. Orbai is a Jerome L. Greene Foundation Scholar and is supported in part by a research grant from the US National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under award number P30-AR070254 (Core B), a Rheumatology Research Foundation Scientist Development award, and a Staurulakis Family Discovery award. A. Duarte-García is supported by the Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, which receives no industry funding. A. Duarte-García, MD, Division of Rheumatology, Department of Medicine, Mayo Clinic, and Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic; Y.Y. Leung, MD, MBChB, Department of Rheumatology and Immunology, Singapore General Hospital; L.C. Coates, PhD, MBChB, University of Leeds, and University of Oxford; D. Beaton, PhD, MSc, BScOT, Musculoskeletal Health and Outcomes Research, St. Michael’s Hospital, and Institute for Work and Health, and Department of Occupational Science and Occupational Therapy, Rehabilitation Sciences Institute and the Institute for Health Policy Management and Evaluation, University of Toronto; R. Christensen, PhD, MSc, Musculoskeletal Statistics Unit: The Parker Institute, Bispebjerg and Frederiksberg Hospital, and Department of Rheumatology, Odense University Hospital; E.T. Craig, MD, MPH, Division of Rheumatology, Department of Medicine, University of Pennsylvania; M. de Wit, PhD, Department of Medical Humanities, Patient Research Partner, Amsterdam University Medical Centre; L. Eder, MD, PhD, Department of Medicine, University of Toronto, Women’s College Hospital; L. Fallon, PhD, Pfizer Inc.; O. FitzGerald, MD, MBChB, Department of Rheumatology, St. Vincent’s University Hospital, and Conway Institute for Biomolecular Research, University College Dublin; D.D. Gladman, MD, Department of Medicine, University of Toronto, Toronto Western Hospital; N. Goel, MD, Patient Research Partner, Division of Rheumatology, Duke University School of Medicine, and Kezar Life Sciences; R. Holland, MBChB, Royal Prince Alfred Hospital Medical Centre; C. Lindsay, PharmD, Patient Research Partner, Amgen Inc.; L. Maxwell, PhD, Cochrane Musculoskeletal Group, Ottawa Hospital Research Institute, Centre for Practice-Changing Research; P. Mease, MD, Swedish-Providence-St. John’s Health Systems and University of Washington; A.M. Orbai, MD, MHS, Division of Rheumatology, Johns Hopkins University School of Medicine; B. Shea, PhD, Ottawa Hospital Research Institute, and School of Epidemiology and Public Health, University of Ottawa; V. Strand, MD, Biopharmaceutical Consultant; D.J. Veale, MD, St. Vincent’s University Hospital, and University College Dublin; W. Tillett, PhD, MBChB, Royal National Hospital for Rheumatic Diseases, and the University of Bath; A. Ogdie, MD, MSCE, Division of Rheumatology, Department of Medicine, University of Pennsylvania. Dr. Duarte-García and Dr. Leung are co-first authors. W. Tillett and Dr. Ogdie are co-senior authors. Address correspondence to Dr. A. Ogdie, University of Pennsylvania, White Building Room 5023, 3400 Spruce St., Philadelphia, Pennsylvania 19104, USA. E-mail: alexis.ogdie@uphs.upenn.edu. Accepted for publication January 30, 2019.
Ying Ying Leung
From the Division of Rheumatology, Department of Medicine, and the Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, Minnesota; Division of Rheumatology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Rheumatology, Duke University School of Medicine, Durham, North Carolina; Kezar Life Sciences, South San Francisco; Amgen Inc., Thousand Oaks, California; Swedish-Providence- St. John’s Health Systems and University of Washington, Seattle, Washington; Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Department of Rheumatology and Immunology, Singapore General Hospital, Singapore, Singapore; University of Leeds, Leeds; University of Oxford, Oxford; Royal National Hospital for Rheumatic Diseases; University of Bath, Bath, UK; Musculoskeletal Health and Outcomes Research, St. Michael’s Hospital; Institute for Work and Health; Department of Occupational Science and Occupational Therapy, Rehabilitation Sciences Institute and the Institute for Health Policy Management and Evaluation, University of Toronto; Department of Medicine, University of Toronto, Women’s College Hospital; Department of Medicine, University of Toronto, Toronto Western Hospital, Toronto; Cochrane Musculoskeletal Group, Ottawa Hospital Research Institute, Centre for Practice-Changing Research; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario; Pfizer Inc., Montreal, Quebec, Canada; Musculoskeletal Statistics Unit: The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen; Department of Rheumatology, Odense University Hospital, Odense, Denmark; Department of Medical Humanities, Patient Research Partner, Amsterdam University Medical Centre, Amsterdam, the Netherlands; Department of Rheumatology, St. Vincent’s University Hospital; Conway Institute for Biomolecular Research, University College Dublin, Ireland; Royal Prince Alfred Hospital Medical Centre, Sydney, Australia. Several parts of this study were funded by the Rheumatology Research Foundation Innovative Research Award (PI Ogdie) and some by R01- AR072363 (PI Ogdie). The Parker Institute, Bispebjerg and Frederiksberg Hospital (RC) is supported by a core grant from the Oak Foundation (OCAY-13-309). A.M. Orbai is a Jerome L. Greene Foundation Scholar and is supported in part by a research grant from the US National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under award number P30-AR070254 (Core B), a Rheumatology Research Foundation Scientist Development award, and a Staurulakis Family Discovery award. A. Duarte-García is supported by the Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, which receives no industry funding. A. Duarte-García, MD, Division of Rheumatology, Department of Medicine, Mayo Clinic, and Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic; Y.Y. Leung, MD, MBChB, Department of Rheumatology and Immunology, Singapore General Hospital; L.C. Coates, PhD, MBChB, University of Leeds, and University of Oxford; D. Beaton, PhD, MSc, BScOT, Musculoskeletal Health and Outcomes Research, St. Michael’s Hospital, and Institute for Work and Health, and Department of Occupational Science and Occupational Therapy, Rehabilitation Sciences Institute and the Institute for Health Policy Management and Evaluation, University of Toronto; R. Christensen, PhD, MSc, Musculoskeletal Statistics Unit: The Parker Institute, Bispebjerg and Frederiksberg Hospital, and Department of Rheumatology, Odense University Hospital; E.T. Craig, MD, MPH, Division of Rheumatology, Department of Medicine, University of Pennsylvania; M. de Wit, PhD, Department of Medical Humanities, Patient Research Partner, Amsterdam University Medical Centre; L. Eder, MD, PhD, Department of Medicine, University of Toronto, Women’s College Hospital; L. Fallon, PhD, Pfizer Inc.; O. FitzGerald, MD, MBChB, Department of Rheumatology, St. Vincent’s University Hospital, and Conway Institute for Biomolecular Research, University College Dublin; D.D. Gladman, MD, Department of Medicine, University of Toronto, Toronto Western Hospital; N. Goel, MD, Patient Research Partner, Division of Rheumatology, Duke University School of Medicine, and Kezar Life Sciences; R. Holland, MBChB, Royal Prince Alfred Hospital Medical Centre; C. Lindsay, PharmD, Patient Research Partner, Amgen Inc.; L. Maxwell, PhD, Cochrane Musculoskeletal Group, Ottawa Hospital Research Institute, Centre for Practice-Changing Research; P. Mease, MD, Swedish-Providence-St. John’s Health Systems and University of Washington; A.M. Orbai, MD, MHS, Division of Rheumatology, Johns Hopkins University School of Medicine; B. Shea, PhD, Ottawa Hospital Research Institute, and School of Epidemiology and Public Health, University of Ottawa; V. Strand, MD, Biopharmaceutical Consultant; D.J. Veale, MD, St. Vincent’s University Hospital, and University College Dublin; W. Tillett, PhD, MBChB, Royal National Hospital for Rheumatic Diseases, and the University of Bath; A. Ogdie, MD, MSCE, Division of Rheumatology, Department of Medicine, University of Pennsylvania. Dr. Duarte-García and Dr. Leung are co-first authors. W. Tillett and Dr. Ogdie are co-senior authors. Address correspondence to Dr. A. Ogdie, University of Pennsylvania, White Building Room 5023, 3400 Spruce St., Philadelphia, Pennsylvania 19104, USA. E-mail: alexis.ogdie@uphs.upenn.edu. Accepted for publication January 30, 2019.
Laura C. Coates
From the Division of Rheumatology, Department of Medicine, and the Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, Minnesota; Division of Rheumatology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Rheumatology, Duke University School of Medicine, Durham, North Carolina; Kezar Life Sciences, South San Francisco; Amgen Inc., Thousand Oaks, California; Swedish-Providence- St. John’s Health Systems and University of Washington, Seattle, Washington; Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Department of Rheumatology and Immunology, Singapore General Hospital, Singapore, Singapore; University of Leeds, Leeds; University of Oxford, Oxford; Royal National Hospital for Rheumatic Diseases; University of Bath, Bath, UK; Musculoskeletal Health and Outcomes Research, St. Michael’s Hospital; Institute for Work and Health; Department of Occupational Science and Occupational Therapy, Rehabilitation Sciences Institute and the Institute for Health Policy Management and Evaluation, University of Toronto; Department of Medicine, University of Toronto, Women’s College Hospital; Department of Medicine, University of Toronto, Toronto Western Hospital, Toronto; Cochrane Musculoskeletal Group, Ottawa Hospital Research Institute, Centre for Practice-Changing Research; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario; Pfizer Inc., Montreal, Quebec, Canada; Musculoskeletal Statistics Unit: The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen; Department of Rheumatology, Odense University Hospital, Odense, Denmark; Department of Medical Humanities, Patient Research Partner, Amsterdam University Medical Centre, Amsterdam, the Netherlands; Department of Rheumatology, St. Vincent’s University Hospital; Conway Institute for Biomolecular Research, University College Dublin, Ireland; Royal Prince Alfred Hospital Medical Centre, Sydney, Australia. Several parts of this study were funded by the Rheumatology Research Foundation Innovative Research Award (PI Ogdie) and some by R01- AR072363 (PI Ogdie). The Parker Institute, Bispebjerg and Frederiksberg Hospital (RC) is supported by a core grant from the Oak Foundation (OCAY-13-309). A.M. Orbai is a Jerome L. Greene Foundation Scholar and is supported in part by a research grant from the US National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under award number P30-AR070254 (Core B), a Rheumatology Research Foundation Scientist Development award, and a Staurulakis Family Discovery award. A. Duarte-García is supported by the Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, which receives no industry funding. A. Duarte-García, MD, Division of Rheumatology, Department of Medicine, Mayo Clinic, and Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic; Y.Y. Leung, MD, MBChB, Department of Rheumatology and Immunology, Singapore General Hospital; L.C. Coates, PhD, MBChB, University of Leeds, and University of Oxford; D. Beaton, PhD, MSc, BScOT, Musculoskeletal Health and Outcomes Research, St. Michael’s Hospital, and Institute for Work and Health, and Department of Occupational Science and Occupational Therapy, Rehabilitation Sciences Institute and the Institute for Health Policy Management and Evaluation, University of Toronto; R. Christensen, PhD, MSc, Musculoskeletal Statistics Unit: The Parker Institute, Bispebjerg and Frederiksberg Hospital, and Department of Rheumatology, Odense University Hospital; E.T. Craig, MD, MPH, Division of Rheumatology, Department of Medicine, University of Pennsylvania; M. de Wit, PhD, Department of Medical Humanities, Patient Research Partner, Amsterdam University Medical Centre; L. Eder, MD, PhD, Department of Medicine, University of Toronto, Women’s College Hospital; L. Fallon, PhD, Pfizer Inc.; O. FitzGerald, MD, MBChB, Department of Rheumatology, St. Vincent’s University Hospital, and Conway Institute for Biomolecular Research, University College Dublin; D.D. Gladman, MD, Department of Medicine, University of Toronto, Toronto Western Hospital; N. Goel, MD, Patient Research Partner, Division of Rheumatology, Duke University School of Medicine, and Kezar Life Sciences; R. Holland, MBChB, Royal Prince Alfred Hospital Medical Centre; C. Lindsay, PharmD, Patient Research Partner, Amgen Inc.; L. Maxwell, PhD, Cochrane Musculoskeletal Group, Ottawa Hospital Research Institute, Centre for Practice-Changing Research; P. Mease, MD, Swedish-Providence-St. John’s Health Systems and University of Washington; A.M. Orbai, MD, MHS, Division of Rheumatology, Johns Hopkins University School of Medicine; B. Shea, PhD, Ottawa Hospital Research Institute, and School of Epidemiology and Public Health, University of Ottawa; V. Strand, MD, Biopharmaceutical Consultant; D.J. Veale, MD, St. Vincent’s University Hospital, and University College Dublin; W. Tillett, PhD, MBChB, Royal National Hospital for Rheumatic Diseases, and the University of Bath; A. Ogdie, MD, MSCE, Division of Rheumatology, Department of Medicine, University of Pennsylvania. Dr. Duarte-García and Dr. Leung are co-first authors. W. Tillett and Dr. Ogdie are co-senior authors. Address correspondence to Dr. A. Ogdie, University of Pennsylvania, White Building Room 5023, 3400 Spruce St., Philadelphia, Pennsylvania 19104, USA. E-mail: alexis.ogdie@uphs.upenn.edu. Accepted for publication January 30, 2019.
Dorcas Beaton
From the Division of Rheumatology, Department of Medicine, and the Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, Minnesota; Division of Rheumatology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Rheumatology, Duke University School of Medicine, Durham, North Carolina; Kezar Life Sciences, South San Francisco; Amgen Inc., Thousand Oaks, California; Swedish-Providence- St. John’s Health Systems and University of Washington, Seattle, Washington; Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Department of Rheumatology and Immunology, Singapore General Hospital, Singapore, Singapore; University of Leeds, Leeds; University of Oxford, Oxford; Royal National Hospital for Rheumatic Diseases; University of Bath, Bath, UK; Musculoskeletal Health and Outcomes Research, St. Michael’s Hospital; Institute for Work and Health; Department of Occupational Science and Occupational Therapy, Rehabilitation Sciences Institute and the Institute for Health Policy Management and Evaluation, University of Toronto; Department of Medicine, University of Toronto, Women’s College Hospital; Department of Medicine, University of Toronto, Toronto Western Hospital, Toronto; Cochrane Musculoskeletal Group, Ottawa Hospital Research Institute, Centre for Practice-Changing Research; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario; Pfizer Inc., Montreal, Quebec, Canada; Musculoskeletal Statistics Unit: The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen; Department of Rheumatology, Odense University Hospital, Odense, Denmark; Department of Medical Humanities, Patient Research Partner, Amsterdam University Medical Centre, Amsterdam, the Netherlands; Department of Rheumatology, St. Vincent’s University Hospital; Conway Institute for Biomolecular Research, University College Dublin, Ireland; Royal Prince Alfred Hospital Medical Centre, Sydney, Australia. Several parts of this study were funded by the Rheumatology Research Foundation Innovative Research Award (PI Ogdie) and some by R01- AR072363 (PI Ogdie). The Parker Institute, Bispebjerg and Frederiksberg Hospital (RC) is supported by a core grant from the Oak Foundation (OCAY-13-309). A.M. Orbai is a Jerome L. Greene Foundation Scholar and is supported in part by a research grant from the US National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under award number P30-AR070254 (Core B), a Rheumatology Research Foundation Scientist Development award, and a Staurulakis Family Discovery award. A. Duarte-García is supported by the Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, which receives no industry funding. A. Duarte-García, MD, Division of Rheumatology, Department of Medicine, Mayo Clinic, and Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic; Y.Y. Leung, MD, MBChB, Department of Rheumatology and Immunology, Singapore General Hospital; L.C. Coates, PhD, MBChB, University of Leeds, and University of Oxford; D. Beaton, PhD, MSc, BScOT, Musculoskeletal Health and Outcomes Research, St. Michael’s Hospital, and Institute for Work and Health, and Department of Occupational Science and Occupational Therapy, Rehabilitation Sciences Institute and the Institute for Health Policy Management and Evaluation, University of Toronto; R. Christensen, PhD, MSc, Musculoskeletal Statistics Unit: The Parker Institute, Bispebjerg and Frederiksberg Hospital, and Department of Rheumatology, Odense University Hospital; E.T. Craig, MD, MPH, Division of Rheumatology, Department of Medicine, University of Pennsylvania; M. de Wit, PhD, Department of Medical Humanities, Patient Research Partner, Amsterdam University Medical Centre; L. Eder, MD, PhD, Department of Medicine, University of Toronto, Women’s College Hospital; L. Fallon, PhD, Pfizer Inc.; O. FitzGerald, MD, MBChB, Department of Rheumatology, St. Vincent’s University Hospital, and Conway Institute for Biomolecular Research, University College Dublin; D.D. Gladman, MD, Department of Medicine, University of Toronto, Toronto Western Hospital; N. Goel, MD, Patient Research Partner, Division of Rheumatology, Duke University School of Medicine, and Kezar Life Sciences; R. Holland, MBChB, Royal Prince Alfred Hospital Medical Centre; C. Lindsay, PharmD, Patient Research Partner, Amgen Inc.; L. Maxwell, PhD, Cochrane Musculoskeletal Group, Ottawa Hospital Research Institute, Centre for Practice-Changing Research; P. Mease, MD, Swedish-Providence-St. John’s Health Systems and University of Washington; A.M. Orbai, MD, MHS, Division of Rheumatology, Johns Hopkins University School of Medicine; B. Shea, PhD, Ottawa Hospital Research Institute, and School of Epidemiology and Public Health, University of Ottawa; V. Strand, MD, Biopharmaceutical Consultant; D.J. Veale, MD, St. Vincent’s University Hospital, and University College Dublin; W. Tillett, PhD, MBChB, Royal National Hospital for Rheumatic Diseases, and the University of Bath; A. Ogdie, MD, MSCE, Division of Rheumatology, Department of Medicine, University of Pennsylvania. Dr. Duarte-García and Dr. Leung are co-first authors. W. Tillett and Dr. Ogdie are co-senior authors. Address correspondence to Dr. A. Ogdie, University of Pennsylvania, White Building Room 5023, 3400 Spruce St., Philadelphia, Pennsylvania 19104, USA. E-mail: alexis.ogdie@uphs.upenn.edu. Accepted for publication January 30, 2019.
Robin Christensen
From the Division of Rheumatology, Department of Medicine, and the Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, Minnesota; Division of Rheumatology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Rheumatology, Duke University School of Medicine, Durham, North Carolina; Kezar Life Sciences, South San Francisco; Amgen Inc., Thousand Oaks, California; Swedish-Providence- St. John’s Health Systems and University of Washington, Seattle, Washington; Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Department of Rheumatology and Immunology, Singapore General Hospital, Singapore, Singapore; University of Leeds, Leeds; University of Oxford, Oxford; Royal National Hospital for Rheumatic Diseases; University of Bath, Bath, UK; Musculoskeletal Health and Outcomes Research, St. Michael’s Hospital; Institute for Work and Health; Department of Occupational Science and Occupational Therapy, Rehabilitation Sciences Institute and the Institute for Health Policy Management and Evaluation, University of Toronto; Department of Medicine, University of Toronto, Women’s College Hospital; Department of Medicine, University of Toronto, Toronto Western Hospital, Toronto; Cochrane Musculoskeletal Group, Ottawa Hospital Research Institute, Centre for Practice-Changing Research; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario; Pfizer Inc., Montreal, Quebec, Canada; Musculoskeletal Statistics Unit: The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen; Department of Rheumatology, Odense University Hospital, Odense, Denmark; Department of Medical Humanities, Patient Research Partner, Amsterdam University Medical Centre, Amsterdam, the Netherlands; Department of Rheumatology, St. Vincent’s University Hospital; Conway Institute for Biomolecular Research, University College Dublin, Ireland; Royal Prince Alfred Hospital Medical Centre, Sydney, Australia. Several parts of this study were funded by the Rheumatology Research Foundation Innovative Research Award (PI Ogdie) and some by R01- AR072363 (PI Ogdie). The Parker Institute, Bispebjerg and Frederiksberg Hospital (RC) is supported by a core grant from the Oak Foundation (OCAY-13-309). A.M. Orbai is a Jerome L. Greene Foundation Scholar and is supported in part by a research grant from the US National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under award number P30-AR070254 (Core B), a Rheumatology Research Foundation Scientist Development award, and a Staurulakis Family Discovery award. A. Duarte-García is supported by the Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, which receives no industry funding. A. Duarte-García, MD, Division of Rheumatology, Department of Medicine, Mayo Clinic, and Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic; Y.Y. Leung, MD, MBChB, Department of Rheumatology and Immunology, Singapore General Hospital; L.C. Coates, PhD, MBChB, University of Leeds, and University of Oxford; D. Beaton, PhD, MSc, BScOT, Musculoskeletal Health and Outcomes Research, St. Michael’s Hospital, and Institute for Work and Health, and Department of Occupational Science and Occupational Therapy, Rehabilitation Sciences Institute and the Institute for Health Policy Management and Evaluation, University of Toronto; R. Christensen, PhD, MSc, Musculoskeletal Statistics Unit: The Parker Institute, Bispebjerg and Frederiksberg Hospital, and Department of Rheumatology, Odense University Hospital; E.T. Craig, MD, MPH, Division of Rheumatology, Department of Medicine, University of Pennsylvania; M. de Wit, PhD, Department of Medical Humanities, Patient Research Partner, Amsterdam University Medical Centre; L. Eder, MD, PhD, Department of Medicine, University of Toronto, Women’s College Hospital; L. Fallon, PhD, Pfizer Inc.; O. FitzGerald, MD, MBChB, Department of Rheumatology, St. Vincent’s University Hospital, and Conway Institute for Biomolecular Research, University College Dublin; D.D. Gladman, MD, Department of Medicine, University of Toronto, Toronto Western Hospital; N. Goel, MD, Patient Research Partner, Division of Rheumatology, Duke University School of Medicine, and Kezar Life Sciences; R. Holland, MBChB, Royal Prince Alfred Hospital Medical Centre; C. Lindsay, PharmD, Patient Research Partner, Amgen Inc.; L. Maxwell, PhD, Cochrane Musculoskeletal Group, Ottawa Hospital Research Institute, Centre for Practice-Changing Research; P. Mease, MD, Swedish-Providence-St. John’s Health Systems and University of Washington; A.M. Orbai, MD, MHS, Division of Rheumatology, Johns Hopkins University School of Medicine; B. Shea, PhD, Ottawa Hospital Research Institute, and School of Epidemiology and Public Health, University of Ottawa; V. Strand, MD, Biopharmaceutical Consultant; D.J. Veale, MD, St. Vincent’s University Hospital, and University College Dublin; W. Tillett, PhD, MBChB, Royal National Hospital for Rheumatic Diseases, and the University of Bath; A. Ogdie, MD, MSCE, Division of Rheumatology, Department of Medicine, University of Pennsylvania. Dr. Duarte-García and Dr. Leung are co-first authors. W. Tillett and Dr. Ogdie are co-senior authors. Address correspondence to Dr. A. Ogdie, University of Pennsylvania, White Building Room 5023, 3400 Spruce St., Philadelphia, Pennsylvania 19104, USA. E-mail: alexis.ogdie@uphs.upenn.edu. Accepted for publication January 30, 2019.
Ethan T. Craig
From the Division of Rheumatology, Department of Medicine, and the Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, Minnesota; Division of Rheumatology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Rheumatology, Duke University School of Medicine, Durham, North Carolina; Kezar Life Sciences, South San Francisco; Amgen Inc., Thousand Oaks, California; Swedish-Providence- St. John’s Health Systems and University of Washington, Seattle, Washington; Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Department of Rheumatology and Immunology, Singapore General Hospital, Singapore, Singapore; University of Leeds, Leeds; University of Oxford, Oxford; Royal National Hospital for Rheumatic Diseases; University of Bath, Bath, UK; Musculoskeletal Health and Outcomes Research, St. Michael’s Hospital; Institute for Work and Health; Department of Occupational Science and Occupational Therapy, Rehabilitation Sciences Institute and the Institute for Health Policy Management and Evaluation, University of Toronto; Department of Medicine, University of Toronto, Women’s College Hospital; Department of Medicine, University of Toronto, Toronto Western Hospital, Toronto; Cochrane Musculoskeletal Group, Ottawa Hospital Research Institute, Centre for Practice-Changing Research; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario; Pfizer Inc., Montreal, Quebec, Canada; Musculoskeletal Statistics Unit: The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen; Department of Rheumatology, Odense University Hospital, Odense, Denmark; Department of Medical Humanities, Patient Research Partner, Amsterdam University Medical Centre, Amsterdam, the Netherlands; Department of Rheumatology, St. Vincent’s University Hospital; Conway Institute for Biomolecular Research, University College Dublin, Ireland; Royal Prince Alfred Hospital Medical Centre, Sydney, Australia. Several parts of this study were funded by the Rheumatology Research Foundation Innovative Research Award (PI Ogdie) and some by R01- AR072363 (PI Ogdie). The Parker Institute, Bispebjerg and Frederiksberg Hospital (RC) is supported by a core grant from the Oak Foundation (OCAY-13-309). A.M. Orbai is a Jerome L. Greene Foundation Scholar and is supported in part by a research grant from the US National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under award number P30-AR070254 (Core B), a Rheumatology Research Foundation Scientist Development award, and a Staurulakis Family Discovery award. A. Duarte-García is supported by the Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, which receives no industry funding. A. Duarte-García, MD, Division of Rheumatology, Department of Medicine, Mayo Clinic, and Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic; Y.Y. Leung, MD, MBChB, Department of Rheumatology and Immunology, Singapore General Hospital; L.C. Coates, PhD, MBChB, University of Leeds, and University of Oxford; D. Beaton, PhD, MSc, BScOT, Musculoskeletal Health and Outcomes Research, St. Michael’s Hospital, and Institute for Work and Health, and Department of Occupational Science and Occupational Therapy, Rehabilitation Sciences Institute and the Institute for Health Policy Management and Evaluation, University of Toronto; R. Christensen, PhD, MSc, Musculoskeletal Statistics Unit: The Parker Institute, Bispebjerg and Frederiksberg Hospital, and Department of Rheumatology, Odense University Hospital; E.T. Craig, MD, MPH, Division of Rheumatology, Department of Medicine, University of Pennsylvania; M. de Wit, PhD, Department of Medical Humanities, Patient Research Partner, Amsterdam University Medical Centre; L. Eder, MD, PhD, Department of Medicine, University of Toronto, Women’s College Hospital; L. Fallon, PhD, Pfizer Inc.; O. FitzGerald, MD, MBChB, Department of Rheumatology, St. Vincent’s University Hospital, and Conway Institute for Biomolecular Research, University College Dublin; D.D. Gladman, MD, Department of Medicine, University of Toronto, Toronto Western Hospital; N. Goel, MD, Patient Research Partner, Division of Rheumatology, Duke University School of Medicine, and Kezar Life Sciences; R. Holland, MBChB, Royal Prince Alfred Hospital Medical Centre; C. Lindsay, PharmD, Patient Research Partner, Amgen Inc.; L. Maxwell, PhD, Cochrane Musculoskeletal Group, Ottawa Hospital Research Institute, Centre for Practice-Changing Research; P. Mease, MD, Swedish-Providence-St. John’s Health Systems and University of Washington; A.M. Orbai, MD, MHS, Division of Rheumatology, Johns Hopkins University School of Medicine; B. Shea, PhD, Ottawa Hospital Research Institute, and School of Epidemiology and Public Health, University of Ottawa; V. Strand, MD, Biopharmaceutical Consultant; D.J. Veale, MD, St. Vincent’s University Hospital, and University College Dublin; W. Tillett, PhD, MBChB, Royal National Hospital for Rheumatic Diseases, and the University of Bath; A. Ogdie, MD, MSCE, Division of Rheumatology, Department of Medicine, University of Pennsylvania. Dr. Duarte-García and Dr. Leung are co-first authors. W. Tillett and Dr. Ogdie are co-senior authors. Address correspondence to Dr. A. Ogdie, University of Pennsylvania, White Building Room 5023, 3400 Spruce St., Philadelphia, Pennsylvania 19104, USA. E-mail: alexis.ogdie@uphs.upenn.edu. Accepted for publication January 30, 2019.
Maarten de Wit
From the Division of Rheumatology, Department of Medicine, and the Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, Minnesota; Division of Rheumatology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Rheumatology, Duke University School of Medicine, Durham, North Carolina; Kezar Life Sciences, South San Francisco; Amgen Inc., Thousand Oaks, California; Swedish-Providence- St. John’s Health Systems and University of Washington, Seattle, Washington; Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Department of Rheumatology and Immunology, Singapore General Hospital, Singapore, Singapore; University of Leeds, Leeds; University of Oxford, Oxford; Royal National Hospital for Rheumatic Diseases; University of Bath, Bath, UK; Musculoskeletal Health and Outcomes Research, St. Michael’s Hospital; Institute for Work and Health; Department of Occupational Science and Occupational Therapy, Rehabilitation Sciences Institute and the Institute for Health Policy Management and Evaluation, University of Toronto; Department of Medicine, University of Toronto, Women’s College Hospital; Department of Medicine, University of Toronto, Toronto Western Hospital, Toronto; Cochrane Musculoskeletal Group, Ottawa Hospital Research Institute, Centre for Practice-Changing Research; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario; Pfizer Inc., Montreal, Quebec, Canada; Musculoskeletal Statistics Unit: The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen; Department of Rheumatology, Odense University Hospital, Odense, Denmark; Department of Medical Humanities, Patient Research Partner, Amsterdam University Medical Centre, Amsterdam, the Netherlands; Department of Rheumatology, St. Vincent’s University Hospital; Conway Institute for Biomolecular Research, University College Dublin, Ireland; Royal Prince Alfred Hospital Medical Centre, Sydney, Australia. Several parts of this study were funded by the Rheumatology Research Foundation Innovative Research Award (PI Ogdie) and some by R01- AR072363 (PI Ogdie). The Parker Institute, Bispebjerg and Frederiksberg Hospital (RC) is supported by a core grant from the Oak Foundation (OCAY-13-309). A.M. Orbai is a Jerome L. Greene Foundation Scholar and is supported in part by a research grant from the US National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under award number P30-AR070254 (Core B), a Rheumatology Research Foundation Scientist Development award, and a Staurulakis Family Discovery award. A. Duarte-García is supported by the Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, which receives no industry funding. A. Duarte-García, MD, Division of Rheumatology, Department of Medicine, Mayo Clinic, and Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic; Y.Y. Leung, MD, MBChB, Department of Rheumatology and Immunology, Singapore General Hospital; L.C. Coates, PhD, MBChB, University of Leeds, and University of Oxford; D. Beaton, PhD, MSc, BScOT, Musculoskeletal Health and Outcomes Research, St. Michael’s Hospital, and Institute for Work and Health, and Department of Occupational Science and Occupational Therapy, Rehabilitation Sciences Institute and the Institute for Health Policy Management and Evaluation, University of Toronto; R. Christensen, PhD, MSc, Musculoskeletal Statistics Unit: The Parker Institute, Bispebjerg and Frederiksberg Hospital, and Department of Rheumatology, Odense University Hospital; E.T. Craig, MD, MPH, Division of Rheumatology, Department of Medicine, University of Pennsylvania; M. de Wit, PhD, Department of Medical Humanities, Patient Research Partner, Amsterdam University Medical Centre; L. Eder, MD, PhD, Department of Medicine, University of Toronto, Women’s College Hospital; L. Fallon, PhD, Pfizer Inc.; O. FitzGerald, MD, MBChB, Department of Rheumatology, St. Vincent’s University Hospital, and Conway Institute for Biomolecular Research, University College Dublin; D.D. Gladman, MD, Department of Medicine, University of Toronto, Toronto Western Hospital; N. Goel, MD, Patient Research Partner, Division of Rheumatology, Duke University School of Medicine, and Kezar Life Sciences; R. Holland, MBChB, Royal Prince Alfred Hospital Medical Centre; C. Lindsay, PharmD, Patient Research Partner, Amgen Inc.; L. Maxwell, PhD, Cochrane Musculoskeletal Group, Ottawa Hospital Research Institute, Centre for Practice-Changing Research; P. Mease, MD, Swedish-Providence-St. John’s Health Systems and University of Washington; A.M. Orbai, MD, MHS, Division of Rheumatology, Johns Hopkins University School of Medicine; B. Shea, PhD, Ottawa Hospital Research Institute, and School of Epidemiology and Public Health, University of Ottawa; V. Strand, MD, Biopharmaceutical Consultant; D.J. Veale, MD, St. Vincent’s University Hospital, and University College Dublin; W. Tillett, PhD, MBChB, Royal National Hospital for Rheumatic Diseases, and the University of Bath; A. Ogdie, MD, MSCE, Division of Rheumatology, Department of Medicine, University of Pennsylvania. Dr. Duarte-García and Dr. Leung are co-first authors. W. Tillett and Dr. Ogdie are co-senior authors. Address correspondence to Dr. A. Ogdie, University of Pennsylvania, White Building Room 5023, 3400 Spruce St., Philadelphia, Pennsylvania 19104, USA. E-mail: alexis.ogdie@uphs.upenn.edu. Accepted for publication January 30, 2019.
Lihi Eder
From the Division of Rheumatology, Department of Medicine, and the Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, Minnesota; Division of Rheumatology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Rheumatology, Duke University School of Medicine, Durham, North Carolina; Kezar Life Sciences, South San Francisco; Amgen Inc., Thousand Oaks, California; Swedish-Providence- St. John’s Health Systems and University of Washington, Seattle, Washington; Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Department of Rheumatology and Immunology, Singapore General Hospital, Singapore, Singapore; University of Leeds, Leeds; University of Oxford, Oxford; Royal National Hospital for Rheumatic Diseases; University of Bath, Bath, UK; Musculoskeletal Health and Outcomes Research, St. Michael’s Hospital; Institute for Work and Health; Department of Occupational Science and Occupational Therapy, Rehabilitation Sciences Institute and the Institute for Health Policy Management and Evaluation, University of Toronto; Department of Medicine, University of Toronto, Women’s College Hospital; Department of Medicine, University of Toronto, Toronto Western Hospital, Toronto; Cochrane Musculoskeletal Group, Ottawa Hospital Research Institute, Centre for Practice-Changing Research; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario; Pfizer Inc., Montreal, Quebec, Canada; Musculoskeletal Statistics Unit: The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen; Department of Rheumatology, Odense University Hospital, Odense, Denmark; Department of Medical Humanities, Patient Research Partner, Amsterdam University Medical Centre, Amsterdam, the Netherlands; Department of Rheumatology, St. Vincent’s University Hospital; Conway Institute for Biomolecular Research, University College Dublin, Ireland; Royal Prince Alfred Hospital Medical Centre, Sydney, Australia. Several parts of this study were funded by the Rheumatology Research Foundation Innovative Research Award (PI Ogdie) and some by R01- AR072363 (PI Ogdie). The Parker Institute, Bispebjerg and Frederiksberg Hospital (RC) is supported by a core grant from the Oak Foundation (OCAY-13-309). A.M. Orbai is a Jerome L. Greene Foundation Scholar and is supported in part by a research grant from the US National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under award number P30-AR070254 (Core B), a Rheumatology Research Foundation Scientist Development award, and a Staurulakis Family Discovery award. A. Duarte-García is supported by the Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, which receives no industry funding. A. Duarte-García, MD, Division of Rheumatology, Department of Medicine, Mayo Clinic, and Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic; Y.Y. Leung, MD, MBChB, Department of Rheumatology and Immunology, Singapore General Hospital; L.C. Coates, PhD, MBChB, University of Leeds, and University of Oxford; D. Beaton, PhD, MSc, BScOT, Musculoskeletal Health and Outcomes Research, St. Michael’s Hospital, and Institute for Work and Health, and Department of Occupational Science and Occupational Therapy, Rehabilitation Sciences Institute and the Institute for Health Policy Management and Evaluation, University of Toronto; R. Christensen, PhD, MSc, Musculoskeletal Statistics Unit: The Parker Institute, Bispebjerg and Frederiksberg Hospital, and Department of Rheumatology, Odense University Hospital; E.T. Craig, MD, MPH, Division of Rheumatology, Department of Medicine, University of Pennsylvania; M. de Wit, PhD, Department of Medical Humanities, Patient Research Partner, Amsterdam University Medical Centre; L. Eder, MD, PhD, Department of Medicine, University of Toronto, Women’s College Hospital; L. Fallon, PhD, Pfizer Inc.; O. FitzGerald, MD, MBChB, Department of Rheumatology, St. Vincent’s University Hospital, and Conway Institute for Biomolecular Research, University College Dublin; D.D. Gladman, MD, Department of Medicine, University of Toronto, Toronto Western Hospital; N. Goel, MD, Patient Research Partner, Division of Rheumatology, Duke University School of Medicine, and Kezar Life Sciences; R. Holland, MBChB, Royal Prince Alfred Hospital Medical Centre; C. Lindsay, PharmD, Patient Research Partner, Amgen Inc.; L. Maxwell, PhD, Cochrane Musculoskeletal Group, Ottawa Hospital Research Institute, Centre for Practice-Changing Research; P. Mease, MD, Swedish-Providence-St. John’s Health Systems and University of Washington; A.M. Orbai, MD, MHS, Division of Rheumatology, Johns Hopkins University School of Medicine; B. Shea, PhD, Ottawa Hospital Research Institute, and School of Epidemiology and Public Health, University of Ottawa; V. Strand, MD, Biopharmaceutical Consultant; D.J. Veale, MD, St. Vincent’s University Hospital, and University College Dublin; W. Tillett, PhD, MBChB, Royal National Hospital for Rheumatic Diseases, and the University of Bath; A. Ogdie, MD, MSCE, Division of Rheumatology, Department of Medicine, University of Pennsylvania. Dr. Duarte-García and Dr. Leung are co-first authors. W. Tillett and Dr. Ogdie are co-senior authors. Address correspondence to Dr. A. Ogdie, University of Pennsylvania, White Building Room 5023, 3400 Spruce St., Philadelphia, Pennsylvania 19104, USA. E-mail: alexis.ogdie@uphs.upenn.edu. Accepted for publication January 30, 2019.
Lara Fallon
From the Division of Rheumatology, Department of Medicine, and the Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, Minnesota; Division of Rheumatology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Rheumatology, Duke University School of Medicine, Durham, North Carolina; Kezar Life Sciences, South San Francisco; Amgen Inc., Thousand Oaks, California; Swedish-Providence- St. John’s Health Systems and University of Washington, Seattle, Washington; Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Department of Rheumatology and Immunology, Singapore General Hospital, Singapore, Singapore; University of Leeds, Leeds; University of Oxford, Oxford; Royal National Hospital for Rheumatic Diseases; University of Bath, Bath, UK; Musculoskeletal Health and Outcomes Research, St. Michael’s Hospital; Institute for Work and Health; Department of Occupational Science and Occupational Therapy, Rehabilitation Sciences Institute and the Institute for Health Policy Management and Evaluation, University of Toronto; Department of Medicine, University of Toronto, Women’s College Hospital; Department of Medicine, University of Toronto, Toronto Western Hospital, Toronto; Cochrane Musculoskeletal Group, Ottawa Hospital Research Institute, Centre for Practice-Changing Research; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario; Pfizer Inc., Montreal, Quebec, Canada; Musculoskeletal Statistics Unit: The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen; Department of Rheumatology, Odense University Hospital, Odense, Denmark; Department of Medical Humanities, Patient Research Partner, Amsterdam University Medical Centre, Amsterdam, the Netherlands; Department of Rheumatology, St. Vincent’s University Hospital; Conway Institute for Biomolecular Research, University College Dublin, Ireland; Royal Prince Alfred Hospital Medical Centre, Sydney, Australia. Several parts of this study were funded by the Rheumatology Research Foundation Innovative Research Award (PI Ogdie) and some by R01- AR072363 (PI Ogdie). The Parker Institute, Bispebjerg and Frederiksberg Hospital (RC) is supported by a core grant from the Oak Foundation (OCAY-13-309). A.M. Orbai is a Jerome L. Greene Foundation Scholar and is supported in part by a research grant from the US National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under award number P30-AR070254 (Core B), a Rheumatology Research Foundation Scientist Development award, and a Staurulakis Family Discovery award. A. Duarte-García is supported by the Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, which receives no industry funding. A. Duarte-García, MD, Division of Rheumatology, Department of Medicine, Mayo Clinic, and Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic; Y.Y. Leung, MD, MBChB, Department of Rheumatology and Immunology, Singapore General Hospital; L.C. Coates, PhD, MBChB, University of Leeds, and University of Oxford; D. Beaton, PhD, MSc, BScOT, Musculoskeletal Health and Outcomes Research, St. Michael’s Hospital, and Institute for Work and Health, and Department of Occupational Science and Occupational Therapy, Rehabilitation Sciences Institute and the Institute for Health Policy Management and Evaluation, University of Toronto; R. Christensen, PhD, MSc, Musculoskeletal Statistics Unit: The Parker Institute, Bispebjerg and Frederiksberg Hospital, and Department of Rheumatology, Odense University Hospital; E.T. Craig, MD, MPH, Division of Rheumatology, Department of Medicine, University of Pennsylvania; M. de Wit, PhD, Department of Medical Humanities, Patient Research Partner, Amsterdam University Medical Centre; L. Eder, MD, PhD, Department of Medicine, University of Toronto, Women’s College Hospital; L. Fallon, PhD, Pfizer Inc.; O. FitzGerald, MD, MBChB, Department of Rheumatology, St. Vincent’s University Hospital, and Conway Institute for Biomolecular Research, University College Dublin; D.D. Gladman, MD, Department of Medicine, University of Toronto, Toronto Western Hospital; N. Goel, MD, Patient Research Partner, Division of Rheumatology, Duke University School of Medicine, and Kezar Life Sciences; R. Holland, MBChB, Royal Prince Alfred Hospital Medical Centre; C. Lindsay, PharmD, Patient Research Partner, Amgen Inc.; L. Maxwell, PhD, Cochrane Musculoskeletal Group, Ottawa Hospital Research Institute, Centre for Practice-Changing Research; P. Mease, MD, Swedish-Providence-St. John’s Health Systems and University of Washington; A.M. Orbai, MD, MHS, Division of Rheumatology, Johns Hopkins University School of Medicine; B. Shea, PhD, Ottawa Hospital Research Institute, and School of Epidemiology and Public Health, University of Ottawa; V. Strand, MD, Biopharmaceutical Consultant; D.J. Veale, MD, St. Vincent’s University Hospital, and University College Dublin; W. Tillett, PhD, MBChB, Royal National Hospital for Rheumatic Diseases, and the University of Bath; A. Ogdie, MD, MSCE, Division of Rheumatology, Department of Medicine, University of Pennsylvania. Dr. Duarte-García and Dr. Leung are co-first authors. W. Tillett and Dr. Ogdie are co-senior authors. Address correspondence to Dr. A. Ogdie, University of Pennsylvania, White Building Room 5023, 3400 Spruce St., Philadelphia, Pennsylvania 19104, USA. E-mail: alexis.ogdie@uphs.upenn.edu. Accepted for publication January 30, 2019.
Oliver FitzGerald
From the Division of Rheumatology, Department of Medicine, and the Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, Minnesota; Division of Rheumatology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Rheumatology, Duke University School of Medicine, Durham, North Carolina; Kezar Life Sciences, South San Francisco; Amgen Inc., Thousand Oaks, California; Swedish-Providence- St. John’s Health Systems and University of Washington, Seattle, Washington; Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Department of Rheumatology and Immunology, Singapore General Hospital, Singapore, Singapore; University of Leeds, Leeds; University of Oxford, Oxford; Royal National Hospital for Rheumatic Diseases; University of Bath, Bath, UK; Musculoskeletal Health and Outcomes Research, St. Michael’s Hospital; Institute for Work and Health; Department of Occupational Science and Occupational Therapy, Rehabilitation Sciences Institute and the Institute for Health Policy Management and Evaluation, University of Toronto; Department of Medicine, University of Toronto, Women’s College Hospital; Department of Medicine, University of Toronto, Toronto Western Hospital, Toronto; Cochrane Musculoskeletal Group, Ottawa Hospital Research Institute, Centre for Practice-Changing Research; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario; Pfizer Inc., Montreal, Quebec, Canada; Musculoskeletal Statistics Unit: The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen; Department of Rheumatology, Odense University Hospital, Odense, Denmark; Department of Medical Humanities, Patient Research Partner, Amsterdam University Medical Centre, Amsterdam, the Netherlands; Department of Rheumatology, St. Vincent’s University Hospital; Conway Institute for Biomolecular Research, University College Dublin, Ireland; Royal Prince Alfred Hospital Medical Centre, Sydney, Australia. Several parts of this study were funded by the Rheumatology Research Foundation Innovative Research Award (PI Ogdie) and some by R01- AR072363 (PI Ogdie). The Parker Institute, Bispebjerg and Frederiksberg Hospital (RC) is supported by a core grant from the Oak Foundation (OCAY-13-309). A.M. Orbai is a Jerome L. Greene Foundation Scholar and is supported in part by a research grant from the US National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under award number P30-AR070254 (Core B), a Rheumatology Research Foundation Scientist Development award, and a Staurulakis Family Discovery award. A. Duarte-García is supported by the Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, which receives no industry funding. A. Duarte-García, MD, Division of Rheumatology, Department of Medicine, Mayo Clinic, and Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic; Y.Y. Leung, MD, MBChB, Department of Rheumatology and Immunology, Singapore General Hospital; L.C. Coates, PhD, MBChB, University of Leeds, and University of Oxford; D. Beaton, PhD, MSc, BScOT, Musculoskeletal Health and Outcomes Research, St. Michael’s Hospital, and Institute for Work and Health, and Department of Occupational Science and Occupational Therapy, Rehabilitation Sciences Institute and the Institute for Health Policy Management and Evaluation, University of Toronto; R. Christensen, PhD, MSc, Musculoskeletal Statistics Unit: The Parker Institute, Bispebjerg and Frederiksberg Hospital, and Department of Rheumatology, Odense University Hospital; E.T. Craig, MD, MPH, Division of Rheumatology, Department of Medicine, University of Pennsylvania; M. de Wit, PhD, Department of Medical Humanities, Patient Research Partner, Amsterdam University Medical Centre; L. Eder, MD, PhD, Department of Medicine, University of Toronto, Women’s College Hospital; L. Fallon, PhD, Pfizer Inc.; O. FitzGerald, MD, MBChB, Department of Rheumatology, St. Vincent’s University Hospital, and Conway Institute for Biomolecular Research, University College Dublin; D.D. Gladman, MD, Department of Medicine, University of Toronto, Toronto Western Hospital; N. Goel, MD, Patient Research Partner, Division of Rheumatology, Duke University School of Medicine, and Kezar Life Sciences; R. Holland, MBChB, Royal Prince Alfred Hospital Medical Centre; C. Lindsay, PharmD, Patient Research Partner, Amgen Inc.; L. Maxwell, PhD, Cochrane Musculoskeletal Group, Ottawa Hospital Research Institute, Centre for Practice-Changing Research; P. Mease, MD, Swedish-Providence-St. John’s Health Systems and University of Washington; A.M. Orbai, MD, MHS, Division of Rheumatology, Johns Hopkins University School of Medicine; B. Shea, PhD, Ottawa Hospital Research Institute, and School of Epidemiology and Public Health, University of Ottawa; V. Strand, MD, Biopharmaceutical Consultant; D.J. Veale, MD, St. Vincent’s University Hospital, and University College Dublin; W. Tillett, PhD, MBChB, Royal National Hospital for Rheumatic Diseases, and the University of Bath; A. Ogdie, MD, MSCE, Division of Rheumatology, Department of Medicine, University of Pennsylvania. Dr. Duarte-García and Dr. Leung are co-first authors. W. Tillett and Dr. Ogdie are co-senior authors. Address correspondence to Dr. A. Ogdie, University of Pennsylvania, White Building Room 5023, 3400 Spruce St., Philadelphia, Pennsylvania 19104, USA. E-mail: alexis.ogdie@uphs.upenn.edu. Accepted for publication January 30, 2019.
Dafna D. Gladman
From the Division of Rheumatology, Department of Medicine, and the Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, Minnesota; Division of Rheumatology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Rheumatology, Duke University School of Medicine, Durham, North Carolina; Kezar Life Sciences, South San Francisco; Amgen Inc., Thousand Oaks, California; Swedish-Providence- St. John’s Health Systems and University of Washington, Seattle, Washington; Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Department of Rheumatology and Immunology, Singapore General Hospital, Singapore, Singapore; University of Leeds, Leeds; University of Oxford, Oxford; Royal National Hospital for Rheumatic Diseases; University of Bath, Bath, UK; Musculoskeletal Health and Outcomes Research, St. Michael’s Hospital; Institute for Work and Health; Department of Occupational Science and Occupational Therapy, Rehabilitation Sciences Institute and the Institute for Health Policy Management and Evaluation, University of Toronto; Department of Medicine, University of Toronto, Women’s College Hospital; Department of Medicine, University of Toronto, Toronto Western Hospital, Toronto; Cochrane Musculoskeletal Group, Ottawa Hospital Research Institute, Centre for Practice-Changing Research; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario; Pfizer Inc., Montreal, Quebec, Canada; Musculoskeletal Statistics Unit: The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen; Department of Rheumatology, Odense University Hospital, Odense, Denmark; Department of Medical Humanities, Patient Research Partner, Amsterdam University Medical Centre, Amsterdam, the Netherlands; Department of Rheumatology, St. Vincent’s University Hospital; Conway Institute for Biomolecular Research, University College Dublin, Ireland; Royal Prince Alfred Hospital Medical Centre, Sydney, Australia. Several parts of this study were funded by the Rheumatology Research Foundation Innovative Research Award (PI Ogdie) and some by R01- AR072363 (PI Ogdie). The Parker Institute, Bispebjerg and Frederiksberg Hospital (RC) is supported by a core grant from the Oak Foundation (OCAY-13-309). A.M. Orbai is a Jerome L. Greene Foundation Scholar and is supported in part by a research grant from the US National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under award number P30-AR070254 (Core B), a Rheumatology Research Foundation Scientist Development award, and a Staurulakis Family Discovery award. A. Duarte-García is supported by the Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, which receives no industry funding. A. Duarte-García, MD, Division of Rheumatology, Department of Medicine, Mayo Clinic, and Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic; Y.Y. Leung, MD, MBChB, Department of Rheumatology and Immunology, Singapore General Hospital; L.C. Coates, PhD, MBChB, University of Leeds, and University of Oxford; D. Beaton, PhD, MSc, BScOT, Musculoskeletal Health and Outcomes Research, St. Michael’s Hospital, and Institute for Work and Health, and Department of Occupational Science and Occupational Therapy, Rehabilitation Sciences Institute and the Institute for Health Policy Management and Evaluation, University of Toronto; R. Christensen, PhD, MSc, Musculoskeletal Statistics Unit: The Parker Institute, Bispebjerg and Frederiksberg Hospital, and Department of Rheumatology, Odense University Hospital; E.T. Craig, MD, MPH, Division of Rheumatology, Department of Medicine, University of Pennsylvania; M. de Wit, PhD, Department of Medical Humanities, Patient Research Partner, Amsterdam University Medical Centre; L. Eder, MD, PhD, Department of Medicine, University of Toronto, Women’s College Hospital; L. Fallon, PhD, Pfizer Inc.; O. FitzGerald, MD, MBChB, Department of Rheumatology, St. Vincent’s University Hospital, and Conway Institute for Biomolecular Research, University College Dublin; D.D. Gladman, MD, Department of Medicine, University of Toronto, Toronto Western Hospital; N. Goel, MD, Patient Research Partner, Division of Rheumatology, Duke University School of Medicine, and Kezar Life Sciences; R. Holland, MBChB, Royal Prince Alfred Hospital Medical Centre; C. Lindsay, PharmD, Patient Research Partner, Amgen Inc.; L. Maxwell, PhD, Cochrane Musculoskeletal Group, Ottawa Hospital Research Institute, Centre for Practice-Changing Research; P. Mease, MD, Swedish-Providence-St. John’s Health Systems and University of Washington; A.M. Orbai, MD, MHS, Division of Rheumatology, Johns Hopkins University School of Medicine; B. Shea, PhD, Ottawa Hospital Research Institute, and School of Epidemiology and Public Health, University of Ottawa; V. Strand, MD, Biopharmaceutical Consultant; D.J. Veale, MD, St. Vincent’s University Hospital, and University College Dublin; W. Tillett, PhD, MBChB, Royal National Hospital for Rheumatic Diseases, and the University of Bath; A. Ogdie, MD, MSCE, Division of Rheumatology, Department of Medicine, University of Pennsylvania. Dr. Duarte-García and Dr. Leung are co-first authors. W. Tillett and Dr. Ogdie are co-senior authors. Address correspondence to Dr. A. Ogdie, University of Pennsylvania, White Building Room 5023, 3400 Spruce St., Philadelphia, Pennsylvania 19104, USA. E-mail: alexis.ogdie@uphs.upenn.edu. Accepted for publication January 30, 2019.
Niti Goel
From the Division of Rheumatology, Department of Medicine, and the Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, Minnesota; Division of Rheumatology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Rheumatology, Duke University School of Medicine, Durham, North Carolina; Kezar Life Sciences, South San Francisco; Amgen Inc., Thousand Oaks, California; Swedish-Providence- St. John’s Health Systems and University of Washington, Seattle, Washington; Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Department of Rheumatology and Immunology, Singapore General Hospital, Singapore, Singapore; University of Leeds, Leeds; University of Oxford, Oxford; Royal National Hospital for Rheumatic Diseases; University of Bath, Bath, UK; Musculoskeletal Health and Outcomes Research, St. Michael’s Hospital; Institute for Work and Health; Department of Occupational Science and Occupational Therapy, Rehabilitation Sciences Institute and the Institute for Health Policy Management and Evaluation, University of Toronto; Department of Medicine, University of Toronto, Women’s College Hospital; Department of Medicine, University of Toronto, Toronto Western Hospital, Toronto; Cochrane Musculoskeletal Group, Ottawa Hospital Research Institute, Centre for Practice-Changing Research; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario; Pfizer Inc., Montreal, Quebec, Canada; Musculoskeletal Statistics Unit: The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen; Department of Rheumatology, Odense University Hospital, Odense, Denmark; Department of Medical Humanities, Patient Research Partner, Amsterdam University Medical Centre, Amsterdam, the Netherlands; Department of Rheumatology, St. Vincent’s University Hospital; Conway Institute for Biomolecular Research, University College Dublin, Ireland; Royal Prince Alfred Hospital Medical Centre, Sydney, Australia. Several parts of this study were funded by the Rheumatology Research Foundation Innovative Research Award (PI Ogdie) and some by R01- AR072363 (PI Ogdie). The Parker Institute, Bispebjerg and Frederiksberg Hospital (RC) is supported by a core grant from the Oak Foundation (OCAY-13-309). A.M. Orbai is a Jerome L. Greene Foundation Scholar and is supported in part by a research grant from the US National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under award number P30-AR070254 (Core B), a Rheumatology Research Foundation Scientist Development award, and a Staurulakis Family Discovery award. A. Duarte-García is supported by the Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, which receives no industry funding. A. Duarte-García, MD, Division of Rheumatology, Department of Medicine, Mayo Clinic, and Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic; Y.Y. Leung, MD, MBChB, Department of Rheumatology and Immunology, Singapore General Hospital; L.C. Coates, PhD, MBChB, University of Leeds, and University of Oxford; D. Beaton, PhD, MSc, BScOT, Musculoskeletal Health and Outcomes Research, St. Michael’s Hospital, and Institute for Work and Health, and Department of Occupational Science and Occupational Therapy, Rehabilitation Sciences Institute and the Institute for Health Policy Management and Evaluation, University of Toronto; R. Christensen, PhD, MSc, Musculoskeletal Statistics Unit: The Parker Institute, Bispebjerg and Frederiksberg Hospital, and Department of Rheumatology, Odense University Hospital; E.T. Craig, MD, MPH, Division of Rheumatology, Department of Medicine, University of Pennsylvania; M. de Wit, PhD, Department of Medical Humanities, Patient Research Partner, Amsterdam University Medical Centre; L. Eder, MD, PhD, Department of Medicine, University of Toronto, Women’s College Hospital; L. Fallon, PhD, Pfizer Inc.; O. FitzGerald, MD, MBChB, Department of Rheumatology, St. Vincent’s University Hospital, and Conway Institute for Biomolecular Research, University College Dublin; D.D. Gladman, MD, Department of Medicine, University of Toronto, Toronto Western Hospital; N. Goel, MD, Patient Research Partner, Division of Rheumatology, Duke University School of Medicine, and Kezar Life Sciences; R. Holland, MBChB, Royal Prince Alfred Hospital Medical Centre; C. Lindsay, PharmD, Patient Research Partner, Amgen Inc.; L. Maxwell, PhD, Cochrane Musculoskeletal Group, Ottawa Hospital Research Institute, Centre for Practice-Changing Research; P. Mease, MD, Swedish-Providence-St. John’s Health Systems and University of Washington; A.M. Orbai, MD, MHS, Division of Rheumatology, Johns Hopkins University School of Medicine; B. Shea, PhD, Ottawa Hospital Research Institute, and School of Epidemiology and Public Health, University of Ottawa; V. Strand, MD, Biopharmaceutical Consultant; D.J. Veale, MD, St. Vincent’s University Hospital, and University College Dublin; W. Tillett, PhD, MBChB, Royal National Hospital for Rheumatic Diseases, and the University of Bath; A. Ogdie, MD, MSCE, Division of Rheumatology, Department of Medicine, University of Pennsylvania. Dr. Duarte-García and Dr. Leung are co-first authors. W. Tillett and Dr. Ogdie are co-senior authors. Address correspondence to Dr. A. Ogdie, University of Pennsylvania, White Building Room 5023, 3400 Spruce St., Philadelphia, Pennsylvania 19104, USA. E-mail: alexis.ogdie@uphs.upenn.edu. Accepted for publication January 30, 2019.
Richard Holland
From the Division of Rheumatology, Department of Medicine, and the Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, Minnesota; Division of Rheumatology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Rheumatology, Duke University School of Medicine, Durham, North Carolina; Kezar Life Sciences, South San Francisco; Amgen Inc., Thousand Oaks, California; Swedish-Providence- St. John’s Health Systems and University of Washington, Seattle, Washington; Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Department of Rheumatology and Immunology, Singapore General Hospital, Singapore, Singapore; University of Leeds, Leeds; University of Oxford, Oxford; Royal National Hospital for Rheumatic Diseases; University of Bath, Bath, UK; Musculoskeletal Health and Outcomes Research, St. Michael’s Hospital; Institute for Work and Health; Department of Occupational Science and Occupational Therapy, Rehabilitation Sciences Institute and the Institute for Health Policy Management and Evaluation, University of Toronto; Department of Medicine, University of Toronto, Women’s College Hospital; Department of Medicine, University of Toronto, Toronto Western Hospital, Toronto; Cochrane Musculoskeletal Group, Ottawa Hospital Research Institute, Centre for Practice-Changing Research; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario; Pfizer Inc., Montreal, Quebec, Canada; Musculoskeletal Statistics Unit: The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen; Department of Rheumatology, Odense University Hospital, Odense, Denmark; Department of Medical Humanities, Patient Research Partner, Amsterdam University Medical Centre, Amsterdam, the Netherlands; Department of Rheumatology, St. Vincent’s University Hospital; Conway Institute for Biomolecular Research, University College Dublin, Ireland; Royal Prince Alfred Hospital Medical Centre, Sydney, Australia. Several parts of this study were funded by the Rheumatology Research Foundation Innovative Research Award (PI Ogdie) and some by R01- AR072363 (PI Ogdie). The Parker Institute, Bispebjerg and Frederiksberg Hospital (RC) is supported by a core grant from the Oak Foundation (OCAY-13-309). A.M. Orbai is a Jerome L. Greene Foundation Scholar and is supported in part by a research grant from the US National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under award number P30-AR070254 (Core B), a Rheumatology Research Foundation Scientist Development award, and a Staurulakis Family Discovery award. A. Duarte-García is supported by the Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, which receives no industry funding. A. Duarte-García, MD, Division of Rheumatology, Department of Medicine, Mayo Clinic, and Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic; Y.Y. Leung, MD, MBChB, Department of Rheumatology and Immunology, Singapore General Hospital; L.C. Coates, PhD, MBChB, University of Leeds, and University of Oxford; D. Beaton, PhD, MSc, BScOT, Musculoskeletal Health and Outcomes Research, St. Michael’s Hospital, and Institute for Work and Health, and Department of Occupational Science and Occupational Therapy, Rehabilitation Sciences Institute and the Institute for Health Policy Management and Evaluation, University of Toronto; R. Christensen, PhD, MSc, Musculoskeletal Statistics Unit: The Parker Institute, Bispebjerg and Frederiksberg Hospital, and Department of Rheumatology, Odense University Hospital; E.T. Craig, MD, MPH, Division of Rheumatology, Department of Medicine, University of Pennsylvania; M. de Wit, PhD, Department of Medical Humanities, Patient Research Partner, Amsterdam University Medical Centre; L. Eder, MD, PhD, Department of Medicine, University of Toronto, Women’s College Hospital; L. Fallon, PhD, Pfizer Inc.; O. FitzGerald, MD, MBChB, Department of Rheumatology, St. Vincent’s University Hospital, and Conway Institute for Biomolecular Research, University College Dublin; D.D. Gladman, MD, Department of Medicine, University of Toronto, Toronto Western Hospital; N. Goel, MD, Patient Research Partner, Division of Rheumatology, Duke University School of Medicine, and Kezar Life Sciences; R. Holland, MBChB, Royal Prince Alfred Hospital Medical Centre; C. Lindsay, PharmD, Patient Research Partner, Amgen Inc.; L. Maxwell, PhD, Cochrane Musculoskeletal Group, Ottawa Hospital Research Institute, Centre for Practice-Changing Research; P. Mease, MD, Swedish-Providence-St. John’s Health Systems and University of Washington; A.M. Orbai, MD, MHS, Division of Rheumatology, Johns Hopkins University School of Medicine; B. Shea, PhD, Ottawa Hospital Research Institute, and School of Epidemiology and Public Health, University of Ottawa; V. Strand, MD, Biopharmaceutical Consultant; D.J. Veale, MD, St. Vincent’s University Hospital, and University College Dublin; W. Tillett, PhD, MBChB, Royal National Hospital for Rheumatic Diseases, and the University of Bath; A. Ogdie, MD, MSCE, Division of Rheumatology, Department of Medicine, University of Pennsylvania. Dr. Duarte-García and Dr. Leung are co-first authors. W. Tillett and Dr. Ogdie are co-senior authors. Address correspondence to Dr. A. Ogdie, University of Pennsylvania, White Building Room 5023, 3400 Spruce St., Philadelphia, Pennsylvania 19104, USA. E-mail: alexis.ogdie@uphs.upenn.edu. Accepted for publication January 30, 2019.
Chris Lindsay
From the Division of Rheumatology, Department of Medicine, and the Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, Minnesota; Division of Rheumatology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Rheumatology, Duke University School of Medicine, Durham, North Carolina; Kezar Life Sciences, South San Francisco; Amgen Inc., Thousand Oaks, California; Swedish-Providence- St. John’s Health Systems and University of Washington, Seattle, Washington; Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Department of Rheumatology and Immunology, Singapore General Hospital, Singapore, Singapore; University of Leeds, Leeds; University of Oxford, Oxford; Royal National Hospital for Rheumatic Diseases; University of Bath, Bath, UK; Musculoskeletal Health and Outcomes Research, St. Michael’s Hospital; Institute for Work and Health; Department of Occupational Science and Occupational Therapy, Rehabilitation Sciences Institute and the Institute for Health Policy Management and Evaluation, University of Toronto; Department of Medicine, University of Toronto, Women’s College Hospital; Department of Medicine, University of Toronto, Toronto Western Hospital, Toronto; Cochrane Musculoskeletal Group, Ottawa Hospital Research Institute, Centre for Practice-Changing Research; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario; Pfizer Inc., Montreal, Quebec, Canada; Musculoskeletal Statistics Unit: The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen; Department of Rheumatology, Odense University Hospital, Odense, Denmark; Department of Medical Humanities, Patient Research Partner, Amsterdam University Medical Centre, Amsterdam, the Netherlands; Department of Rheumatology, St. Vincent’s University Hospital; Conway Institute for Biomolecular Research, University College Dublin, Ireland; Royal Prince Alfred Hospital Medical Centre, Sydney, Australia. Several parts of this study were funded by the Rheumatology Research Foundation Innovative Research Award (PI Ogdie) and some by R01- AR072363 (PI Ogdie). The Parker Institute, Bispebjerg and Frederiksberg Hospital (RC) is supported by a core grant from the Oak Foundation (OCAY-13-309). A.M. Orbai is a Jerome L. Greene Foundation Scholar and is supported in part by a research grant from the US National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under award number P30-AR070254 (Core B), a Rheumatology Research Foundation Scientist Development award, and a Staurulakis Family Discovery award. A. Duarte-García is supported by the Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, which receives no industry funding. A. Duarte-García, MD, Division of Rheumatology, Department of Medicine, Mayo Clinic, and Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic; Y.Y. Leung, MD, MBChB, Department of Rheumatology and Immunology, Singapore General Hospital; L.C. Coates, PhD, MBChB, University of Leeds, and University of Oxford; D. Beaton, PhD, MSc, BScOT, Musculoskeletal Health and Outcomes Research, St. Michael’s Hospital, and Institute for Work and Health, and Department of Occupational Science and Occupational Therapy, Rehabilitation Sciences Institute and the Institute for Health Policy Management and Evaluation, University of Toronto; R. Christensen, PhD, MSc, Musculoskeletal Statistics Unit: The Parker Institute, Bispebjerg and Frederiksberg Hospital, and Department of Rheumatology, Odense University Hospital; E.T. Craig, MD, MPH, Division of Rheumatology, Department of Medicine, University of Pennsylvania; M. de Wit, PhD, Department of Medical Humanities, Patient Research Partner, Amsterdam University Medical Centre; L. Eder, MD, PhD, Department of Medicine, University of Toronto, Women’s College Hospital; L. Fallon, PhD, Pfizer Inc.; O. FitzGerald, MD, MBChB, Department of Rheumatology, St. Vincent’s University Hospital, and Conway Institute for Biomolecular Research, University College Dublin; D.D. Gladman, MD, Department of Medicine, University of Toronto, Toronto Western Hospital; N. Goel, MD, Patient Research Partner, Division of Rheumatology, Duke University School of Medicine, and Kezar Life Sciences; R. Holland, MBChB, Royal Prince Alfred Hospital Medical Centre; C. Lindsay, PharmD, Patient Research Partner, Amgen Inc.; L. Maxwell, PhD, Cochrane Musculoskeletal Group, Ottawa Hospital Research Institute, Centre for Practice-Changing Research; P. Mease, MD, Swedish-Providence-St. John’s Health Systems and University of Washington; A.M. Orbai, MD, MHS, Division of Rheumatology, Johns Hopkins University School of Medicine; B. Shea, PhD, Ottawa Hospital Research Institute, and School of Epidemiology and Public Health, University of Ottawa; V. Strand, MD, Biopharmaceutical Consultant; D.J. Veale, MD, St. Vincent’s University Hospital, and University College Dublin; W. Tillett, PhD, MBChB, Royal National Hospital for Rheumatic Diseases, and the University of Bath; A. Ogdie, MD, MSCE, Division of Rheumatology, Department of Medicine, University of Pennsylvania. Dr. Duarte-García and Dr. Leung are co-first authors. W. Tillett and Dr. Ogdie are co-senior authors. Address correspondence to Dr. A. Ogdie, University of Pennsylvania, White Building Room 5023, 3400 Spruce St., Philadelphia, Pennsylvania 19104, USA. E-mail: alexis.ogdie@uphs.upenn.edu. Accepted for publication January 30, 2019.
Lara Maxwell
From the Division of Rheumatology, Department of Medicine, and the Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, Minnesota; Division of Rheumatology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Rheumatology, Duke University School of Medicine, Durham, North Carolina; Kezar Life Sciences, South San Francisco; Amgen Inc., Thousand Oaks, California; Swedish-Providence- St. John’s Health Systems and University of Washington, Seattle, Washington; Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Department of Rheumatology and Immunology, Singapore General Hospital, Singapore, Singapore; University of Leeds, Leeds; University of Oxford, Oxford; Royal National Hospital for Rheumatic Diseases; University of Bath, Bath, UK; Musculoskeletal Health and Outcomes Research, St. Michael’s Hospital; Institute for Work and Health; Department of Occupational Science and Occupational Therapy, Rehabilitation Sciences Institute and the Institute for Health Policy Management and Evaluation, University of Toronto; Department of Medicine, University of Toronto, Women’s College Hospital; Department of Medicine, University of Toronto, Toronto Western Hospital, Toronto; Cochrane Musculoskeletal Group, Ottawa Hospital Research Institute, Centre for Practice-Changing Research; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario; Pfizer Inc., Montreal, Quebec, Canada; Musculoskeletal Statistics Unit: The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen; Department of Rheumatology, Odense University Hospital, Odense, Denmark; Department of Medical Humanities, Patient Research Partner, Amsterdam University Medical Centre, Amsterdam, the Netherlands; Department of Rheumatology, St. Vincent’s University Hospital; Conway Institute for Biomolecular Research, University College Dublin, Ireland; Royal Prince Alfred Hospital Medical Centre, Sydney, Australia. Several parts of this study were funded by the Rheumatology Research Foundation Innovative Research Award (PI Ogdie) and some by R01- AR072363 (PI Ogdie). The Parker Institute, Bispebjerg and Frederiksberg Hospital (RC) is supported by a core grant from the Oak Foundation (OCAY-13-309). A.M. Orbai is a Jerome L. Greene Foundation Scholar and is supported in part by a research grant from the US National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under award number P30-AR070254 (Core B), a Rheumatology Research Foundation Scientist Development award, and a Staurulakis Family Discovery award. A. Duarte-García is supported by the Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, which receives no industry funding. A. Duarte-García, MD, Division of Rheumatology, Department of Medicine, Mayo Clinic, and Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic; Y.Y. Leung, MD, MBChB, Department of Rheumatology and Immunology, Singapore General Hospital; L.C. Coates, PhD, MBChB, University of Leeds, and University of Oxford; D. Beaton, PhD, MSc, BScOT, Musculoskeletal Health and Outcomes Research, St. Michael’s Hospital, and Institute for Work and Health, and Department of Occupational Science and Occupational Therapy, Rehabilitation Sciences Institute and the Institute for Health Policy Management and Evaluation, University of Toronto; R. Christensen, PhD, MSc, Musculoskeletal Statistics Unit: The Parker Institute, Bispebjerg and Frederiksberg Hospital, and Department of Rheumatology, Odense University Hospital; E.T. Craig, MD, MPH, Division of Rheumatology, Department of Medicine, University of Pennsylvania; M. de Wit, PhD, Department of Medical Humanities, Patient Research Partner, Amsterdam University Medical Centre; L. Eder, MD, PhD, Department of Medicine, University of Toronto, Women’s College Hospital; L. Fallon, PhD, Pfizer Inc.; O. FitzGerald, MD, MBChB, Department of Rheumatology, St. Vincent’s University Hospital, and Conway Institute for Biomolecular Research, University College Dublin; D.D. Gladman, MD, Department of Medicine, University of Toronto, Toronto Western Hospital; N. Goel, MD, Patient Research Partner, Division of Rheumatology, Duke University School of Medicine, and Kezar Life Sciences; R. Holland, MBChB, Royal Prince Alfred Hospital Medical Centre; C. Lindsay, PharmD, Patient Research Partner, Amgen Inc.; L. Maxwell, PhD, Cochrane Musculoskeletal Group, Ottawa Hospital Research Institute, Centre for Practice-Changing Research; P. Mease, MD, Swedish-Providence-St. John’s Health Systems and University of Washington; A.M. Orbai, MD, MHS, Division of Rheumatology, Johns Hopkins University School of Medicine; B. Shea, PhD, Ottawa Hospital Research Institute, and School of Epidemiology and Public Health, University of Ottawa; V. Strand, MD, Biopharmaceutical Consultant; D.J. Veale, MD, St. Vincent’s University Hospital, and University College Dublin; W. Tillett, PhD, MBChB, Royal National Hospital for Rheumatic Diseases, and the University of Bath; A. Ogdie, MD, MSCE, Division of Rheumatology, Department of Medicine, University of Pennsylvania. Dr. Duarte-García and Dr. Leung are co-first authors. W. Tillett and Dr. Ogdie are co-senior authors. Address correspondence to Dr. A. Ogdie, University of Pennsylvania, White Building Room 5023, 3400 Spruce St., Philadelphia, Pennsylvania 19104, USA. E-mail: alexis.ogdie@uphs.upenn.edu. Accepted for publication January 30, 2019.
Philip Mease
From the Division of Rheumatology, Department of Medicine, and the Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, Minnesota; Division of Rheumatology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Rheumatology, Duke University School of Medicine, Durham, North Carolina; Kezar Life Sciences, South San Francisco; Amgen Inc., Thousand Oaks, California; Swedish-Providence- St. John’s Health Systems and University of Washington, Seattle, Washington; Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Department of Rheumatology and Immunology, Singapore General Hospital, Singapore, Singapore; University of Leeds, Leeds; University of Oxford, Oxford; Royal National Hospital for Rheumatic Diseases; University of Bath, Bath, UK; Musculoskeletal Health and Outcomes Research, St. Michael’s Hospital; Institute for Work and Health; Department of Occupational Science and Occupational Therapy, Rehabilitation Sciences Institute and the Institute for Health Policy Management and Evaluation, University of Toronto; Department of Medicine, University of Toronto, Women’s College Hospital; Department of Medicine, University of Toronto, Toronto Western Hospital, Toronto; Cochrane Musculoskeletal Group, Ottawa Hospital Research Institute, Centre for Practice-Changing Research; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario; Pfizer Inc., Montreal, Quebec, Canada; Musculoskeletal Statistics Unit: The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen; Department of Rheumatology, Odense University Hospital, Odense, Denmark; Department of Medical Humanities, Patient Research Partner, Amsterdam University Medical Centre, Amsterdam, the Netherlands; Department of Rheumatology, St. Vincent’s University Hospital; Conway Institute for Biomolecular Research, University College Dublin, Ireland; Royal Prince Alfred Hospital Medical Centre, Sydney, Australia. Several parts of this study were funded by the Rheumatology Research Foundation Innovative Research Award (PI Ogdie) and some by R01- AR072363 (PI Ogdie). The Parker Institute, Bispebjerg and Frederiksberg Hospital (RC) is supported by a core grant from the Oak Foundation (OCAY-13-309). A.M. Orbai is a Jerome L. Greene Foundation Scholar and is supported in part by a research grant from the US National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under award number P30-AR070254 (Core B), a Rheumatology Research Foundation Scientist Development award, and a Staurulakis Family Discovery award. A. Duarte-García is supported by the Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, which receives no industry funding. A. Duarte-García, MD, Division of Rheumatology, Department of Medicine, Mayo Clinic, and Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic; Y.Y. Leung, MD, MBChB, Department of Rheumatology and Immunology, Singapore General Hospital; L.C. Coates, PhD, MBChB, University of Leeds, and University of Oxford; D. Beaton, PhD, MSc, BScOT, Musculoskeletal Health and Outcomes Research, St. Michael’s Hospital, and Institute for Work and Health, and Department of Occupational Science and Occupational Therapy, Rehabilitation Sciences Institute and the Institute for Health Policy Management and Evaluation, University of Toronto; R. Christensen, PhD, MSc, Musculoskeletal Statistics Unit: The Parker Institute, Bispebjerg and Frederiksberg Hospital, and Department of Rheumatology, Odense University Hospital; E.T. Craig, MD, MPH, Division of Rheumatology, Department of Medicine, University of Pennsylvania; M. de Wit, PhD, Department of Medical Humanities, Patient Research Partner, Amsterdam University Medical Centre; L. Eder, MD, PhD, Department of Medicine, University of Toronto, Women’s College Hospital; L. Fallon, PhD, Pfizer Inc.; O. FitzGerald, MD, MBChB, Department of Rheumatology, St. Vincent’s University Hospital, and Conway Institute for Biomolecular Research, University College Dublin; D.D. Gladman, MD, Department of Medicine, University of Toronto, Toronto Western Hospital; N. Goel, MD, Patient Research Partner, Division of Rheumatology, Duke University School of Medicine, and Kezar Life Sciences; R. Holland, MBChB, Royal Prince Alfred Hospital Medical Centre; C. Lindsay, PharmD, Patient Research Partner, Amgen Inc.; L. Maxwell, PhD, Cochrane Musculoskeletal Group, Ottawa Hospital Research Institute, Centre for Practice-Changing Research; P. Mease, MD, Swedish-Providence-St. John’s Health Systems and University of Washington; A.M. Orbai, MD, MHS, Division of Rheumatology, Johns Hopkins University School of Medicine; B. Shea, PhD, Ottawa Hospital Research Institute, and School of Epidemiology and Public Health, University of Ottawa; V. Strand, MD, Biopharmaceutical Consultant; D.J. Veale, MD, St. Vincent’s University Hospital, and University College Dublin; W. Tillett, PhD, MBChB, Royal National Hospital for Rheumatic Diseases, and the University of Bath; A. Ogdie, MD, MSCE, Division of Rheumatology, Department of Medicine, University of Pennsylvania. Dr. Duarte-García and Dr. Leung are co-first authors. W. Tillett and Dr. Ogdie are co-senior authors. Address correspondence to Dr. A. Ogdie, University of Pennsylvania, White Building Room 5023, 3400 Spruce St., Philadelphia, Pennsylvania 19104, USA. E-mail: alexis.ogdie@uphs.upenn.edu. Accepted for publication January 30, 2019.
Ana Maria Orbai
From the Division of Rheumatology, Department of Medicine, and the Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, Minnesota; Division of Rheumatology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Rheumatology, Duke University School of Medicine, Durham, North Carolina; Kezar Life Sciences, South San Francisco; Amgen Inc., Thousand Oaks, California; Swedish-Providence- St. John’s Health Systems and University of Washington, Seattle, Washington; Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Department of Rheumatology and Immunology, Singapore General Hospital, Singapore, Singapore; University of Leeds, Leeds; University of Oxford, Oxford; Royal National Hospital for Rheumatic Diseases; University of Bath, Bath, UK; Musculoskeletal Health and Outcomes Research, St. Michael’s Hospital; Institute for Work and Health; Department of Occupational Science and Occupational Therapy, Rehabilitation Sciences Institute and the Institute for Health Policy Management and Evaluation, University of Toronto; Department of Medicine, University of Toronto, Women’s College Hospital; Department of Medicine, University of Toronto, Toronto Western Hospital, Toronto; Cochrane Musculoskeletal Group, Ottawa Hospital Research Institute, Centre for Practice-Changing Research; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario; Pfizer Inc., Montreal, Quebec, Canada; Musculoskeletal Statistics Unit: The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen; Department of Rheumatology, Odense University Hospital, Odense, Denmark; Department of Medical Humanities, Patient Research Partner, Amsterdam University Medical Centre, Amsterdam, the Netherlands; Department of Rheumatology, St. Vincent’s University Hospital; Conway Institute for Biomolecular Research, University College Dublin, Ireland; Royal Prince Alfred Hospital Medical Centre, Sydney, Australia. Several parts of this study were funded by the Rheumatology Research Foundation Innovative Research Award (PI Ogdie) and some by R01- AR072363 (PI Ogdie). The Parker Institute, Bispebjerg and Frederiksberg Hospital (RC) is supported by a core grant from the Oak Foundation (OCAY-13-309). A.M. Orbai is a Jerome L. Greene Foundation Scholar and is supported in part by a research grant from the US National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under award number P30-AR070254 (Core B), a Rheumatology Research Foundation Scientist Development award, and a Staurulakis Family Discovery award. A. Duarte-García is supported by the Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, which receives no industry funding. A. Duarte-García, MD, Division of Rheumatology, Department of Medicine, Mayo Clinic, and Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic; Y.Y. Leung, MD, MBChB, Department of Rheumatology and Immunology, Singapore General Hospital; L.C. Coates, PhD, MBChB, University of Leeds, and University of Oxford; D. Beaton, PhD, MSc, BScOT, Musculoskeletal Health and Outcomes Research, St. Michael’s Hospital, and Institute for Work and Health, and Department of Occupational Science and Occupational Therapy, Rehabilitation Sciences Institute and the Institute for Health Policy Management and Evaluation, University of Toronto; R. Christensen, PhD, MSc, Musculoskeletal Statistics Unit: The Parker Institute, Bispebjerg and Frederiksberg Hospital, and Department of Rheumatology, Odense University Hospital; E.T. Craig, MD, MPH, Division of Rheumatology, Department of Medicine, University of Pennsylvania; M. de Wit, PhD, Department of Medical Humanities, Patient Research Partner, Amsterdam University Medical Centre; L. Eder, MD, PhD, Department of Medicine, University of Toronto, Women’s College Hospital; L. Fallon, PhD, Pfizer Inc.; O. FitzGerald, MD, MBChB, Department of Rheumatology, St. Vincent’s University Hospital, and Conway Institute for Biomolecular Research, University College Dublin; D.D. Gladman, MD, Department of Medicine, University of Toronto, Toronto Western Hospital; N. Goel, MD, Patient Research Partner, Division of Rheumatology, Duke University School of Medicine, and Kezar Life Sciences; R. Holland, MBChB, Royal Prince Alfred Hospital Medical Centre; C. Lindsay, PharmD, Patient Research Partner, Amgen Inc.; L. Maxwell, PhD, Cochrane Musculoskeletal Group, Ottawa Hospital Research Institute, Centre for Practice-Changing Research; P. Mease, MD, Swedish-Providence-St. John’s Health Systems and University of Washington; A.M. Orbai, MD, MHS, Division of Rheumatology, Johns Hopkins University School of Medicine; B. Shea, PhD, Ottawa Hospital Research Institute, and School of Epidemiology and Public Health, University of Ottawa; V. Strand, MD, Biopharmaceutical Consultant; D.J. Veale, MD, St. Vincent’s University Hospital, and University College Dublin; W. Tillett, PhD, MBChB, Royal National Hospital for Rheumatic Diseases, and the University of Bath; A. Ogdie, MD, MSCE, Division of Rheumatology, Department of Medicine, University of Pennsylvania. Dr. Duarte-García and Dr. Leung are co-first authors. W. Tillett and Dr. Ogdie are co-senior authors. Address correspondence to Dr. A. Ogdie, University of Pennsylvania, White Building Room 5023, 3400 Spruce St., Philadelphia, Pennsylvania 19104, USA. E-mail: alexis.ogdie@uphs.upenn.edu. Accepted for publication January 30, 2019.
Beverley Shea
From the Division of Rheumatology, Department of Medicine, and the Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, Minnesota; Division of Rheumatology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Rheumatology, Duke University School of Medicine, Durham, North Carolina; Kezar Life Sciences, South San Francisco; Amgen Inc., Thousand Oaks, California; Swedish-Providence- St. John’s Health Systems and University of Washington, Seattle, Washington; Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Department of Rheumatology and Immunology, Singapore General Hospital, Singapore, Singapore; University of Leeds, Leeds; University of Oxford, Oxford; Royal National Hospital for Rheumatic Diseases; University of Bath, Bath, UK; Musculoskeletal Health and Outcomes Research, St. Michael’s Hospital; Institute for Work and Health; Department of Occupational Science and Occupational Therapy, Rehabilitation Sciences Institute and the Institute for Health Policy Management and Evaluation, University of Toronto; Department of Medicine, University of Toronto, Women’s College Hospital; Department of Medicine, University of Toronto, Toronto Western Hospital, Toronto; Cochrane Musculoskeletal Group, Ottawa Hospital Research Institute, Centre for Practice-Changing Research; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario; Pfizer Inc., Montreal, Quebec, Canada; Musculoskeletal Statistics Unit: The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen; Department of Rheumatology, Odense University Hospital, Odense, Denmark; Department of Medical Humanities, Patient Research Partner, Amsterdam University Medical Centre, Amsterdam, the Netherlands; Department of Rheumatology, St. Vincent’s University Hospital; Conway Institute for Biomolecular Research, University College Dublin, Ireland; Royal Prince Alfred Hospital Medical Centre, Sydney, Australia. Several parts of this study were funded by the Rheumatology Research Foundation Innovative Research Award (PI Ogdie) and some by R01- AR072363 (PI Ogdie). The Parker Institute, Bispebjerg and Frederiksberg Hospital (RC) is supported by a core grant from the Oak Foundation (OCAY-13-309). A.M. Orbai is a Jerome L. Greene Foundation Scholar and is supported in part by a research grant from the US National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under award number P30-AR070254 (Core B), a Rheumatology Research Foundation Scientist Development award, and a Staurulakis Family Discovery award. A. Duarte-García is supported by the Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, which receives no industry funding. A. Duarte-García, MD, Division of Rheumatology, Department of Medicine, Mayo Clinic, and Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic; Y.Y. Leung, MD, MBChB, Department of Rheumatology and Immunology, Singapore General Hospital; L.C. Coates, PhD, MBChB, University of Leeds, and University of Oxford; D. Beaton, PhD, MSc, BScOT, Musculoskeletal Health and Outcomes Research, St. Michael’s Hospital, and Institute for Work and Health, and Department of Occupational Science and Occupational Therapy, Rehabilitation Sciences Institute and the Institute for Health Policy Management and Evaluation, University of Toronto; R. Christensen, PhD, MSc, Musculoskeletal Statistics Unit: The Parker Institute, Bispebjerg and Frederiksberg Hospital, and Department of Rheumatology, Odense University Hospital; E.T. Craig, MD, MPH, Division of Rheumatology, Department of Medicine, University of Pennsylvania; M. de Wit, PhD, Department of Medical Humanities, Patient Research Partner, Amsterdam University Medical Centre; L. Eder, MD, PhD, Department of Medicine, University of Toronto, Women’s College Hospital; L. Fallon, PhD, Pfizer Inc.; O. FitzGerald, MD, MBChB, Department of Rheumatology, St. Vincent’s University Hospital, and Conway Institute for Biomolecular Research, University College Dublin; D.D. Gladman, MD, Department of Medicine, University of Toronto, Toronto Western Hospital; N. Goel, MD, Patient Research Partner, Division of Rheumatology, Duke University School of Medicine, and Kezar Life Sciences; R. Holland, MBChB, Royal Prince Alfred Hospital Medical Centre; C. Lindsay, PharmD, Patient Research Partner, Amgen Inc.; L. Maxwell, PhD, Cochrane Musculoskeletal Group, Ottawa Hospital Research Institute, Centre for Practice-Changing Research; P. Mease, MD, Swedish-Providence-St. John’s Health Systems and University of Washington; A.M. Orbai, MD, MHS, Division of Rheumatology, Johns Hopkins University School of Medicine; B. Shea, PhD, Ottawa Hospital Research Institute, and School of Epidemiology and Public Health, University of Ottawa; V. Strand, MD, Biopharmaceutical Consultant; D.J. Veale, MD, St. Vincent’s University Hospital, and University College Dublin; W. Tillett, PhD, MBChB, Royal National Hospital for Rheumatic Diseases, and the University of Bath; A. Ogdie, MD, MSCE, Division of Rheumatology, Department of Medicine, University of Pennsylvania. Dr. Duarte-García and Dr. Leung are co-first authors. W. Tillett and Dr. Ogdie are co-senior authors. Address correspondence to Dr. A. Ogdie, University of Pennsylvania, White Building Room 5023, 3400 Spruce St., Philadelphia, Pennsylvania 19104, USA. E-mail: alexis.ogdie@uphs.upenn.edu. Accepted for publication January 30, 2019.
Vibeke Strand
From the Division of Rheumatology, Department of Medicine, and the Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, Minnesota; Division of Rheumatology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Rheumatology, Duke University School of Medicine, Durham, North Carolina; Kezar Life Sciences, South San Francisco; Amgen Inc., Thousand Oaks, California; Swedish-Providence- St. John’s Health Systems and University of Washington, Seattle, Washington; Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Department of Rheumatology and Immunology, Singapore General Hospital, Singapore, Singapore; University of Leeds, Leeds; University of Oxford, Oxford; Royal National Hospital for Rheumatic Diseases; University of Bath, Bath, UK; Musculoskeletal Health and Outcomes Research, St. Michael’s Hospital; Institute for Work and Health; Department of Occupational Science and Occupational Therapy, Rehabilitation Sciences Institute and the Institute for Health Policy Management and Evaluation, University of Toronto; Department of Medicine, University of Toronto, Women’s College Hospital; Department of Medicine, University of Toronto, Toronto Western Hospital, Toronto; Cochrane Musculoskeletal Group, Ottawa Hospital Research Institute, Centre for Practice-Changing Research; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario; Pfizer Inc., Montreal, Quebec, Canada; Musculoskeletal Statistics Unit: The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen; Department of Rheumatology, Odense University Hospital, Odense, Denmark; Department of Medical Humanities, Patient Research Partner, Amsterdam University Medical Centre, Amsterdam, the Netherlands; Department of Rheumatology, St. Vincent’s University Hospital; Conway Institute for Biomolecular Research, University College Dublin, Ireland; Royal Prince Alfred Hospital Medical Centre, Sydney, Australia. Several parts of this study were funded by the Rheumatology Research Foundation Innovative Research Award (PI Ogdie) and some by R01- AR072363 (PI Ogdie). The Parker Institute, Bispebjerg and Frederiksberg Hospital (RC) is supported by a core grant from the Oak Foundation (OCAY-13-309). A.M. Orbai is a Jerome L. Greene Foundation Scholar and is supported in part by a research grant from the US National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under award number P30-AR070254 (Core B), a Rheumatology Research Foundation Scientist Development award, and a Staurulakis Family Discovery award. A. Duarte-García is supported by the Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, which receives no industry funding. A. Duarte-García, MD, Division of Rheumatology, Department of Medicine, Mayo Clinic, and Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic; Y.Y. Leung, MD, MBChB, Department of Rheumatology and Immunology, Singapore General Hospital; L.C. Coates, PhD, MBChB, University of Leeds, and University of Oxford; D. Beaton, PhD, MSc, BScOT, Musculoskeletal Health and Outcomes Research, St. Michael’s Hospital, and Institute for Work and Health, and Department of Occupational Science and Occupational Therapy, Rehabilitation Sciences Institute and the Institute for Health Policy Management and Evaluation, University of Toronto; R. Christensen, PhD, MSc, Musculoskeletal Statistics Unit: The Parker Institute, Bispebjerg and Frederiksberg Hospital, and Department of Rheumatology, Odense University Hospital; E.T. Craig, MD, MPH, Division of Rheumatology, Department of Medicine, University of Pennsylvania; M. de Wit, PhD, Department of Medical Humanities, Patient Research Partner, Amsterdam University Medical Centre; L. Eder, MD, PhD, Department of Medicine, University of Toronto, Women’s College Hospital; L. Fallon, PhD, Pfizer Inc.; O. FitzGerald, MD, MBChB, Department of Rheumatology, St. Vincent’s University Hospital, and Conway Institute for Biomolecular Research, University College Dublin; D.D. Gladman, MD, Department of Medicine, University of Toronto, Toronto Western Hospital; N. Goel, MD, Patient Research Partner, Division of Rheumatology, Duke University School of Medicine, and Kezar Life Sciences; R. Holland, MBChB, Royal Prince Alfred Hospital Medical Centre; C. Lindsay, PharmD, Patient Research Partner, Amgen Inc.; L. Maxwell, PhD, Cochrane Musculoskeletal Group, Ottawa Hospital Research Institute, Centre for Practice-Changing Research; P. Mease, MD, Swedish-Providence-St. John’s Health Systems and University of Washington; A.M. Orbai, MD, MHS, Division of Rheumatology, Johns Hopkins University School of Medicine; B. Shea, PhD, Ottawa Hospital Research Institute, and School of Epidemiology and Public Health, University of Ottawa; V. Strand, MD, Biopharmaceutical Consultant; D.J. Veale, MD, St. Vincent’s University Hospital, and University College Dublin; W. Tillett, PhD, MBChB, Royal National Hospital for Rheumatic Diseases, and the University of Bath; A. Ogdie, MD, MSCE, Division of Rheumatology, Department of Medicine, University of Pennsylvania. Dr. Duarte-García and Dr. Leung are co-first authors. W. Tillett and Dr. Ogdie are co-senior authors. Address correspondence to Dr. A. Ogdie, University of Pennsylvania, White Building Room 5023, 3400 Spruce St., Philadelphia, Pennsylvania 19104, USA. E-mail: alexis.ogdie@uphs.upenn.edu. Accepted for publication January 30, 2019.
Douglas J. Veale
From the Division of Rheumatology, Department of Medicine, and the Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, Minnesota; Division of Rheumatology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Rheumatology, Duke University School of Medicine, Durham, North Carolina; Kezar Life Sciences, South San Francisco; Amgen Inc., Thousand Oaks, California; Swedish-Providence- St. John’s Health Systems and University of Washington, Seattle, Washington; Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Department of Rheumatology and Immunology, Singapore General Hospital, Singapore, Singapore; University of Leeds, Leeds; University of Oxford, Oxford; Royal National Hospital for Rheumatic Diseases; University of Bath, Bath, UK; Musculoskeletal Health and Outcomes Research, St. Michael’s Hospital; Institute for Work and Health; Department of Occupational Science and Occupational Therapy, Rehabilitation Sciences Institute and the Institute for Health Policy Management and Evaluation, University of Toronto; Department of Medicine, University of Toronto, Women’s College Hospital; Department of Medicine, University of Toronto, Toronto Western Hospital, Toronto; Cochrane Musculoskeletal Group, Ottawa Hospital Research Institute, Centre for Practice-Changing Research; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario; Pfizer Inc., Montreal, Quebec, Canada; Musculoskeletal Statistics Unit: The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen; Department of Rheumatology, Odense University Hospital, Odense, Denmark; Department of Medical Humanities, Patient Research Partner, Amsterdam University Medical Centre, Amsterdam, the Netherlands; Department of Rheumatology, St. Vincent’s University Hospital; Conway Institute for Biomolecular Research, University College Dublin, Ireland; Royal Prince Alfred Hospital Medical Centre, Sydney, Australia. Several parts of this study were funded by the Rheumatology Research Foundation Innovative Research Award (PI Ogdie) and some by R01- AR072363 (PI Ogdie). The Parker Institute, Bispebjerg and Frederiksberg Hospital (RC) is supported by a core grant from the Oak Foundation (OCAY-13-309). A.M. Orbai is a Jerome L. Greene Foundation Scholar and is supported in part by a research grant from the US National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under award number P30-AR070254 (Core B), a Rheumatology Research Foundation Scientist Development award, and a Staurulakis Family Discovery award. A. Duarte-García is supported by the Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, which receives no industry funding. A. Duarte-García, MD, Division of Rheumatology, Department of Medicine, Mayo Clinic, and Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic; Y.Y. Leung, MD, MBChB, Department of Rheumatology and Immunology, Singapore General Hospital; L.C. Coates, PhD, MBChB, University of Leeds, and University of Oxford; D. Beaton, PhD, MSc, BScOT, Musculoskeletal Health and Outcomes Research, St. Michael’s Hospital, and Institute for Work and Health, and Department of Occupational Science and Occupational Therapy, Rehabilitation Sciences Institute and the Institute for Health Policy Management and Evaluation, University of Toronto; R. Christensen, PhD, MSc, Musculoskeletal Statistics Unit: The Parker Institute, Bispebjerg and Frederiksberg Hospital, and Department of Rheumatology, Odense University Hospital; E.T. Craig, MD, MPH, Division of Rheumatology, Department of Medicine, University of Pennsylvania; M. de Wit, PhD, Department of Medical Humanities, Patient Research Partner, Amsterdam University Medical Centre; L. Eder, MD, PhD, Department of Medicine, University of Toronto, Women’s College Hospital; L. Fallon, PhD, Pfizer Inc.; O. FitzGerald, MD, MBChB, Department of Rheumatology, St. Vincent’s University Hospital, and Conway Institute for Biomolecular Research, University College Dublin; D.D. Gladman, MD, Department of Medicine, University of Toronto, Toronto Western Hospital; N. Goel, MD, Patient Research Partner, Division of Rheumatology, Duke University School of Medicine, and Kezar Life Sciences; R. Holland, MBChB, Royal Prince Alfred Hospital Medical Centre; C. Lindsay, PharmD, Patient Research Partner, Amgen Inc.; L. Maxwell, PhD, Cochrane Musculoskeletal Group, Ottawa Hospital Research Institute, Centre for Practice-Changing Research; P. Mease, MD, Swedish-Providence-St. John’s Health Systems and University of Washington; A.M. Orbai, MD, MHS, Division of Rheumatology, Johns Hopkins University School of Medicine; B. Shea, PhD, Ottawa Hospital Research Institute, and School of Epidemiology and Public Health, University of Ottawa; V. Strand, MD, Biopharmaceutical Consultant; D.J. Veale, MD, St. Vincent’s University Hospital, and University College Dublin; W. Tillett, PhD, MBChB, Royal National Hospital for Rheumatic Diseases, and the University of Bath; A. Ogdie, MD, MSCE, Division of Rheumatology, Department of Medicine, University of Pennsylvania. Dr. Duarte-García and Dr. Leung are co-first authors. W. Tillett and Dr. Ogdie are co-senior authors. Address correspondence to Dr. A. Ogdie, University of Pennsylvania, White Building Room 5023, 3400 Spruce St., Philadelphia, Pennsylvania 19104, USA. E-mail: alexis.ogdie@uphs.upenn.edu. Accepted for publication January 30, 2019.
William Tillett
From the Division of Rheumatology, Department of Medicine, and the Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, Minnesota; Division of Rheumatology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Rheumatology, Duke University School of Medicine, Durham, North Carolina; Kezar Life Sciences, South San Francisco; Amgen Inc., Thousand Oaks, California; Swedish-Providence- St. John’s Health Systems and University of Washington, Seattle, Washington; Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Department of Rheumatology and Immunology, Singapore General Hospital, Singapore, Singapore; University of Leeds, Leeds; University of Oxford, Oxford; Royal National Hospital for Rheumatic Diseases; University of Bath, Bath, UK; Musculoskeletal Health and Outcomes Research, St. Michael’s Hospital; Institute for Work and Health; Department of Occupational Science and Occupational Therapy, Rehabilitation Sciences Institute and the Institute for Health Policy Management and Evaluation, University of Toronto; Department of Medicine, University of Toronto, Women’s College Hospital; Department of Medicine, University of Toronto, Toronto Western Hospital, Toronto; Cochrane Musculoskeletal Group, Ottawa Hospital Research Institute, Centre for Practice-Changing Research; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario; Pfizer Inc., Montreal, Quebec, Canada; Musculoskeletal Statistics Unit: The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen; Department of Rheumatology, Odense University Hospital, Odense, Denmark; Department of Medical Humanities, Patient Research Partner, Amsterdam University Medical Centre, Amsterdam, the Netherlands; Department of Rheumatology, St. Vincent’s University Hospital; Conway Institute for Biomolecular Research, University College Dublin, Ireland; Royal Prince Alfred Hospital Medical Centre, Sydney, Australia. Several parts of this study were funded by the Rheumatology Research Foundation Innovative Research Award (PI Ogdie) and some by R01- AR072363 (PI Ogdie). The Parker Institute, Bispebjerg and Frederiksberg Hospital (RC) is supported by a core grant from the Oak Foundation (OCAY-13-309). A.M. Orbai is a Jerome L. Greene Foundation Scholar and is supported in part by a research grant from the US National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under award number P30-AR070254 (Core B), a Rheumatology Research Foundation Scientist Development award, and a Staurulakis Family Discovery award. A. Duarte-García is supported by the Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, which receives no industry funding. A. Duarte-García, MD, Division of Rheumatology, Department of Medicine, Mayo Clinic, and Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic; Y.Y. Leung, MD, MBChB, Department of Rheumatology and Immunology, Singapore General Hospital; L.C. Coates, PhD, MBChB, University of Leeds, and University of Oxford; D. Beaton, PhD, MSc, BScOT, Musculoskeletal Health and Outcomes Research, St. Michael’s Hospital, and Institute for Work and Health, and Department of Occupational Science and Occupational Therapy, Rehabilitation Sciences Institute and the Institute for Health Policy Management and Evaluation, University of Toronto; R. Christensen, PhD, MSc, Musculoskeletal Statistics Unit: The Parker Institute, Bispebjerg and Frederiksberg Hospital, and Department of Rheumatology, Odense University Hospital; E.T. Craig, MD, MPH, Division of Rheumatology, Department of Medicine, University of Pennsylvania; M. de Wit, PhD, Department of Medical Humanities, Patient Research Partner, Amsterdam University Medical Centre; L. Eder, MD, PhD, Department of Medicine, University of Toronto, Women’s College Hospital; L. Fallon, PhD, Pfizer Inc.; O. FitzGerald, MD, MBChB, Department of Rheumatology, St. Vincent’s University Hospital, and Conway Institute for Biomolecular Research, University College Dublin; D.D. Gladman, MD, Department of Medicine, University of Toronto, Toronto Western Hospital; N. Goel, MD, Patient Research Partner, Division of Rheumatology, Duke University School of Medicine, and Kezar Life Sciences; R. Holland, MBChB, Royal Prince Alfred Hospital Medical Centre; C. Lindsay, PharmD, Patient Research Partner, Amgen Inc.; L. Maxwell, PhD, Cochrane Musculoskeletal Group, Ottawa Hospital Research Institute, Centre for Practice-Changing Research; P. Mease, MD, Swedish-Providence-St. John’s Health Systems and University of Washington; A.M. Orbai, MD, MHS, Division of Rheumatology, Johns Hopkins University School of Medicine; B. Shea, PhD, Ottawa Hospital Research Institute, and School of Epidemiology and Public Health, University of Ottawa; V. Strand, MD, Biopharmaceutical Consultant; D.J. Veale, MD, St. Vincent’s University Hospital, and University College Dublin; W. Tillett, PhD, MBChB, Royal National Hospital for Rheumatic Diseases, and the University of Bath; A. Ogdie, MD, MSCE, Division of Rheumatology, Department of Medicine, University of Pennsylvania. Dr. Duarte-García and Dr. Leung are co-first authors. W. Tillett and Dr. Ogdie are co-senior authors. Address correspondence to Dr. A. Ogdie, University of Pennsylvania, White Building Room 5023, 3400 Spruce St., Philadelphia, Pennsylvania 19104, USA. E-mail: alexis.ogdie@uphs.upenn.edu. Accepted for publication January 30, 2019.
Alexis Ogdie
From the Division of Rheumatology, Department of Medicine, and the Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, Minnesota; Division of Rheumatology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Rheumatology, Duke University School of Medicine, Durham, North Carolina; Kezar Life Sciences, South San Francisco; Amgen Inc., Thousand Oaks, California; Swedish-Providence- St. John’s Health Systems and University of Washington, Seattle, Washington; Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Department of Rheumatology and Immunology, Singapore General Hospital, Singapore, Singapore; University of Leeds, Leeds; University of Oxford, Oxford; Royal National Hospital for Rheumatic Diseases; University of Bath, Bath, UK; Musculoskeletal Health and Outcomes Research, St. Michael’s Hospital; Institute for Work and Health; Department of Occupational Science and Occupational Therapy, Rehabilitation Sciences Institute and the Institute for Health Policy Management and Evaluation, University of Toronto; Department of Medicine, University of Toronto, Women’s College Hospital; Department of Medicine, University of Toronto, Toronto Western Hospital, Toronto; Cochrane Musculoskeletal Group, Ottawa Hospital Research Institute, Centre for Practice-Changing Research; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario; Pfizer Inc., Montreal, Quebec, Canada; Musculoskeletal Statistics Unit: The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen; Department of Rheumatology, Odense University Hospital, Odense, Denmark; Department of Medical Humanities, Patient Research Partner, Amsterdam University Medical Centre, Amsterdam, the Netherlands; Department of Rheumatology, St. Vincent’s University Hospital; Conway Institute for Biomolecular Research, University College Dublin, Ireland; Royal Prince Alfred Hospital Medical Centre, Sydney, Australia. Several parts of this study were funded by the Rheumatology Research Foundation Innovative Research Award (PI Ogdie) and some by R01- AR072363 (PI Ogdie). The Parker Institute, Bispebjerg and Frederiksberg Hospital (RC) is supported by a core grant from the Oak Foundation (OCAY-13-309). A.M. Orbai is a Jerome L. Greene Foundation Scholar and is supported in part by a research grant from the US National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under award number P30-AR070254 (Core B), a Rheumatology Research Foundation Scientist Development award, and a Staurulakis Family Discovery award. A. Duarte-García is supported by the Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, which receives no industry funding. A. Duarte-García, MD, Division of Rheumatology, Department of Medicine, Mayo Clinic, and Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic; Y.Y. Leung, MD, MBChB, Department of Rheumatology and Immunology, Singapore General Hospital; L.C. Coates, PhD, MBChB, University of Leeds, and University of Oxford; D. Beaton, PhD, MSc, BScOT, Musculoskeletal Health and Outcomes Research, St. Michael’s Hospital, and Institute for Work and Health, and Department of Occupational Science and Occupational Therapy, Rehabilitation Sciences Institute and the Institute for Health Policy Management and Evaluation, University of Toronto; R. Christensen, PhD, MSc, Musculoskeletal Statistics Unit: The Parker Institute, Bispebjerg and Frederiksberg Hospital, and Department of Rheumatology, Odense University Hospital; E.T. Craig, MD, MPH, Division of Rheumatology, Department of Medicine, University of Pennsylvania; M. de Wit, PhD, Department of Medical Humanities, Patient Research Partner, Amsterdam University Medical Centre; L. Eder, MD, PhD, Department of Medicine, University of Toronto, Women’s College Hospital; L. Fallon, PhD, Pfizer Inc.; O. FitzGerald, MD, MBChB, Department of Rheumatology, St. Vincent’s University Hospital, and Conway Institute for Biomolecular Research, University College Dublin; D.D. Gladman, MD, Department of Medicine, University of Toronto, Toronto Western Hospital; N. Goel, MD, Patient Research Partner, Division of Rheumatology, Duke University School of Medicine, and Kezar Life Sciences; R. Holland, MBChB, Royal Prince Alfred Hospital Medical Centre; C. Lindsay, PharmD, Patient Research Partner, Amgen Inc.; L. Maxwell, PhD, Cochrane Musculoskeletal Group, Ottawa Hospital Research Institute, Centre for Practice-Changing Research; P. Mease, MD, Swedish-Providence-St. John’s Health Systems and University of Washington; A.M. Orbai, MD, MHS, Division of Rheumatology, Johns Hopkins University School of Medicine; B. Shea, PhD, Ottawa Hospital Research Institute, and School of Epidemiology and Public Health, University of Ottawa; V. Strand, MD, Biopharmaceutical Consultant; D.J. Veale, MD, St. Vincent’s University Hospital, and University College Dublin; W. Tillett, PhD, MBChB, Royal National Hospital for Rheumatic Diseases, and the University of Bath; A. Ogdie, MD, MSCE, Division of Rheumatology, Department of Medicine, University of Pennsylvania. Dr. Duarte-García and Dr. Leung are co-first authors. W. Tillett and Dr. Ogdie are co-senior authors. Address correspondence to Dr. A. Ogdie, University of Pennsylvania, White Building Room 5023, 3400 Spruce St., Philadelphia, Pennsylvania 19104, USA. E-mail: alexis.ogdie@uphs.upenn.edu. Accepted for publication January 30, 2019.
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- Alí Duarte-García,
- Ying Ying Leung,
- Laura C. Coates,
- Dorcas Beaton,
- Robin Christensen,
- Ethan T. Craig,
- Maarten de Wit,
- Lihi Eder,
- Lara Fallon,
- Oliver FitzGerald,
- Dafna D. Gladman,
- Niti Goel,
- Richard Holland,
- Chris Lindsay,
- Lara Maxwell,
- Philip Mease,
- Ana Maria Orbai,
- Beverley Shea,
- Vibeke Strand,
- Douglas J. Veale,
- William Tillett and
- Alexis Ogdie
- From the Division of Rheumatology, Department of Medicine, and the Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, Minnesota; Division of Rheumatology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Rheumatology, Duke University School of Medicine, Durham, North Carolina; Kezar Life Sciences, South San Francisco; Amgen Inc., Thousand Oaks, California; Swedish-Providence- St. John’s Health Systems and University of Washington, Seattle, Washington; Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Department of Rheumatology and Immunology, Singapore General Hospital, Singapore, Singapore; University of Leeds, Leeds; University of Oxford, Oxford; Royal National Hospital for Rheumatic Diseases; University of Bath, Bath, UK; Musculoskeletal Health and Outcomes Research, St. Michael’s Hospital; Institute for Work and Health; Department of Occupational Science and Occupational Therapy, Rehabilitation Sciences Institute and the Institute for Health Policy Management and Evaluation, University of Toronto; Department of Medicine, University of Toronto, Women’s College Hospital; Department of Medicine, University of Toronto, Toronto Western Hospital, Toronto; Cochrane Musculoskeletal Group, Ottawa Hospital Research Institute, Centre for Practice-Changing Research; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario; Pfizer Inc., Montreal, Quebec, Canada; Musculoskeletal Statistics Unit: The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen; Department of Rheumatology, Odense University Hospital, Odense, Denmark; Department of Medical Humanities, Patient Research Partner, Amsterdam University Medical Centre, Amsterdam, the Netherlands; Department of Rheumatology, St. Vincent’s University Hospital; Conway Institute for Biomolecular Research, University College Dublin, Ireland; Royal Prince Alfred Hospital Medical Centre, Sydney, Australia.
Several parts of this study were funded by the Rheumatology Research Foundation Innovative Research Award (PI Ogdie) and some by R01- AR072363 (PI Ogdie). The Parker Institute, Bispebjerg and Frederiksberg Hospital (RC) is supported by a core grant from the Oak Foundation (OCAY-13-309). A.M. Orbai is a Jerome L. Greene Foundation Scholar and is supported in part by a research grant from the US National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under award number P30-AR070254 (Core B), a Rheumatology Research Foundation Scientist Development award, and a Staurulakis Family Discovery award. A. Duarte-García is supported by the Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, which receives no industry funding.
A. Duarte-García, MD, Division of Rheumatology, Department of Medicine, Mayo Clinic, and Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic; Y.Y. Leung, MD, MBChB, Department of Rheumatology and Immunology, Singapore General Hospital; L.C. Coates, PhD, MBChB, University of Leeds, and University of Oxford; D. Beaton, PhD, MSc, BScOT, Musculoskeletal Health and Outcomes Research, St. Michael’s Hospital, and Institute for Work and Health, and Department of Occupational Science and Occupational Therapy, Rehabilitation Sciences Institute and the Institute for Health Policy Management and Evaluation, University of Toronto; R. Christensen, PhD, MSc, Musculoskeletal Statistics Unit: The Parker Institute, Bispebjerg and Frederiksberg Hospital, and Department of Rheumatology, Odense University Hospital; E.T. Craig, MD, MPH, Division of Rheumatology, Department of Medicine, University of Pennsylvania; M. de Wit, PhD, Department of Medical Humanities, Patient Research Partner, Amsterdam University Medical Centre; L. Eder, MD, PhD, Department of Medicine, University of Toronto, Women’s College Hospital; L. Fallon, PhD, Pfizer Inc.; O. FitzGerald, MD, MBChB, Department of Rheumatology, St. Vincent’s University Hospital, and Conway Institute for Biomolecular Research, University College Dublin; D.D. Gladman, MD, Department of Medicine, University of Toronto, Toronto Western Hospital; N. Goel, MD, Patient Research Partner, Division of Rheumatology, Duke University School of Medicine, and Kezar Life Sciences; R. Holland, MBChB, Royal Prince Alfred Hospital Medical Centre; C. Lindsay, PharmD, Patient Research Partner, Amgen Inc.; L. Maxwell, PhD, Cochrane Musculoskeletal Group, Ottawa Hospital Research Institute, Centre for Practice-Changing Research; P. Mease, MD, Swedish-Providence-St. John’s Health Systems and University of Washington; A.M. Orbai, MD, MHS, Division of Rheumatology, Johns Hopkins University School of Medicine; B. Shea, PhD, Ottawa Hospital Research Institute, and School of Epidemiology and Public Health, University of Ottawa; V. Strand, MD, Biopharmaceutical Consultant; D.J. Veale, MD, St. Vincent’s University Hospital, and University College Dublin; W. Tillett, PhD, MBChB, Royal National Hospital for Rheumatic Diseases, and the University of Bath; A. Ogdie, MD, MSCE, Division of Rheumatology, Department of Medicine, University of Pennsylvania. Dr. Duarte-García and Dr. Leung are co-first authors. W. Tillett and Dr. Ogdie are co-senior authors.
Address correspondence to Dr. A. Ogdie, University of Pennsylvania, White Building Room 5023, 3400 Spruce St., Philadelphia, Pennsylvania 19104, USA. E-mail: alexis.ogdie@uphs.upenn.edu.
Accepted for publication January 30, 2019.
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The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Endorsement of the 66/68 Joint Count for the Measurement of Musculoskeletal Disease Activity: OMERACT 2018 Psoriatic Arthritis Workshop Report
Alí Duarte-García, Ying Ying Leung, Laura C. Coates, Dorcas Beaton, Robin Christensen, Ethan T. Craig, Maarten de Wit, Lihi Eder, Lara Fallon, Oliver FitzGerald, Dafna D. Gladman, Niti Goel, Richard Holland, Chris Lindsay, Lara Maxwell, Philip Mease, Ana Maria Orbai, Beverley Shea, Vibeke Strand, Douglas J. Veale, William Tillett, Alexis Ogdie
The Journal of Rheumatology Feb 2019, jrheum.181089; DOI: 10.3899/jrheum.181089
Endorsement of the 66/68 Joint Count for the Measurement of Musculoskeletal Disease Activity: OMERACT 2018 Psoriatic Arthritis Workshop Report
Alí Duarte-García, Ying Ying Leung, Laura C. Coates, Dorcas Beaton, Robin Christensen, Ethan T. Craig, Maarten de Wit, Lihi Eder, Lara Fallon, Oliver FitzGerald, Dafna D. Gladman, Niti Goel, Richard Holland, Chris Lindsay, Lara Maxwell, Philip Mease, Ana Maria Orbai, Beverley Shea, Vibeke Strand, Douglas J. Veale, William Tillett, Alexis Ogdie
The Journal of Rheumatology Feb 2019, jrheum.181089; DOI: 10.3899/jrheum.181089