Research ArticleArticle
Feasibility and Construct Validation of the Patient Reported Outcomes Measurement Information System in Systemic Vasculitis
Gunnar Tomasson, John T. Farrar, David Cuthbertson, Carol A. McAlear, Susan Ashdown, Peter F. Cronholm, Jill Dawson, Don Gebhart, Georgia Lanier, Raashid A. Luqmani, Nataliya Milman, Jacqueline Peck, Joanna C. Robson, Judy A. Shea, Simon Carette, Nader Khalidi, Curry L. Koening, Carol A. Langford, Paul A. Monach, Larry Moreland, Christian Pagnoux, Ulrich Specks, Antoine G. Sreih, Steven R. Ytterberg and Peter A. Merkel for the Vasculitis Clinical
Research Consortium
The Journal of Rheumatology March 2019, jrheum.171405; DOI: https://doi.org/10.3899/jrheum.171405
Gunnar Tomasson
From the Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland; Department of Rheumatology, and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; Department of Biostatistics, Epidemiology, and Informatics, and Division of Rheumatology, and Department of Family Medicine and Community Health, and Division of General Internal Medicine, University of Pennsylvania, Philadelphia; Division of Rheumatology, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Biostatistics and Informatics, Department of Pediatrics, University of South Florida, Tampa, Florida; Division of Rheumatology, University of Utah, Salt Lake City, Utah; Department of Rheumatology, Cleveland Clinic, Cleveland; Ohio State University Wexner Medical Center, Columbus, Ohio; Section of Rheumatology, Boston University School of Medicine, Boston, Massachusetts; Division of Rheumatology, and Division of Pulmonology and Critical Care Medicine, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA; Nuffield Department of Population Health, Health Services Research Unit (HSRU), and Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford; Faculty of Health and Applied Sciences, University of the West of England, Bristol and School of Clinical Sciences, University of Bristol, Bristol, UK; Department of Rheumatology, University of Ottawa, Ottawa; Division of Rheumatology, Mount Sinai Hospital, Toronto; Division of Rheumatology, St. Joseph’s Healthcare, McMaster University, Hamilton, Ontario, Canada. This work was supported by The Vasculitis Clinical Research Consortium (VCRC; U54 AR057319 and R01 AR 064153), which is part of the Rare Diseases Clinical Research Network, an initiative of the US Office of Rare Diseases Research, National Center for Advancing Translational Science (NCATS). The VCRC is funded through collaboration between NCATS, and the National Institute of Arthritis and Musculoskeletal and Skin Diseases, and has received funding from the National Center for Research Resources (U54 RR019497). Additional support for this work was provided by a contract from the Patient-Centered Outcomes Research Institute (IP2PI000603). G. Tomasson, MD, PhD, Assistant Professor, Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland, and Department of Rheumatology, and Centre for Rheumatology Research, University Hospital; J.T. Farrar, MD, Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania; D. Cuthbertson, MS, Department of Biostatistics and Informatics, Department of Pediatrics, University of South Florida; C.A. McAlear, MA, Division of Rheumatology, University of Pennsylvania; S. Ashdown, RN, Oxfordshire; P.F. Cronholm, MD, MSCE, Department of Family Medicine and Community Health, University of Pennsylvania; J. Dawson, MA, MSc, DPhil, SRN, SCM, Nuffield Department of Population Health (HSRU), University of Oxford; D. Gebhart, MD, Ohio State University Wexner Medical Center, Columbus; G. Lanier, Patient Research Partner, Boston; R.A. Luqmani, DM, FRCP, FRCP(E), Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; N. Milman, MD, MSc, FRCPC, Department of Rheumatology, University of Ottawa; J. Peck, RN, Faculty of Health and Applied Sciences, University of the West of England, Bristol and School of Clinical Sciences, University of Bristol; J.A. Shea, PhD, Division of General Internal Medicine, University of Pennsylvania; S. Carette, MD, Division of Rheumatology, Mount Sinai Hospital; N. Khalidi, MD, Division of Rheumatology, St. Joseph’s Healthcare, McMaster University; C.L. Koening, MD, Division of Rheumatology, University of Utah; C.A. Langford, MD, Department of Rheumatology, Cleveland Clinic; P.A. Monach, MD, PhD, Section of Rheumatology, Boston University School of Medicine; L. Moreland, MD, Division of Rheumatology, University of Pittsburgh; C. Pagnoux, MD, MSc, MPH, Division of Rheumatology, Mount Sinai Hospital; U. Specks, MD, Division of Pulmonology and Critical Care Medicine, Mayo Clinic College of Medicine and Science; A.G. Sreih, MD, Division of Rheumatology, University of Pennsylvania; S.R. Ytterberg, MD, Division of Rheumatology, Mayo Clinic College of Medicine and Science; P.A. Merkel, MD, MPH, Division of Rheumatology, University of Pennsylvania. Address correspondence to Dr. G. Tomasson, Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland, Sturlugata 8, 101 Reykjavik, Iceland. E-mail: gunnar.tomasson@gmail.com. Accepted for publication November 26, 2018.
John T. Farrar
From the Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland; Department of Rheumatology, and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; Department of Biostatistics, Epidemiology, and Informatics, and Division of Rheumatology, and Department of Family Medicine and Community Health, and Division of General Internal Medicine, University of Pennsylvania, Philadelphia; Division of Rheumatology, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Biostatistics and Informatics, Department of Pediatrics, University of South Florida, Tampa, Florida; Division of Rheumatology, University of Utah, Salt Lake City, Utah; Department of Rheumatology, Cleveland Clinic, Cleveland; Ohio State University Wexner Medical Center, Columbus, Ohio; Section of Rheumatology, Boston University School of Medicine, Boston, Massachusetts; Division of Rheumatology, and Division of Pulmonology and Critical Care Medicine, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA; Nuffield Department of Population Health, Health Services Research Unit (HSRU), and Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford; Faculty of Health and Applied Sciences, University of the West of England, Bristol and School of Clinical Sciences, University of Bristol, Bristol, UK; Department of Rheumatology, University of Ottawa, Ottawa; Division of Rheumatology, Mount Sinai Hospital, Toronto; Division of Rheumatology, St. Joseph’s Healthcare, McMaster University, Hamilton, Ontario, Canada. This work was supported by The Vasculitis Clinical Research Consortium (VCRC; U54 AR057319 and R01 AR 064153), which is part of the Rare Diseases Clinical Research Network, an initiative of the US Office of Rare Diseases Research, National Center for Advancing Translational Science (NCATS). The VCRC is funded through collaboration between NCATS, and the National Institute of Arthritis and Musculoskeletal and Skin Diseases, and has received funding from the National Center for Research Resources (U54 RR019497). Additional support for this work was provided by a contract from the Patient-Centered Outcomes Research Institute (IP2PI000603). G. Tomasson, MD, PhD, Assistant Professor, Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland, and Department of Rheumatology, and Centre for Rheumatology Research, University Hospital; J.T. Farrar, MD, Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania; D. Cuthbertson, MS, Department of Biostatistics and Informatics, Department of Pediatrics, University of South Florida; C.A. McAlear, MA, Division of Rheumatology, University of Pennsylvania; S. Ashdown, RN, Oxfordshire; P.F. Cronholm, MD, MSCE, Department of Family Medicine and Community Health, University of Pennsylvania; J. Dawson, MA, MSc, DPhil, SRN, SCM, Nuffield Department of Population Health (HSRU), University of Oxford; D. Gebhart, MD, Ohio State University Wexner Medical Center, Columbus; G. Lanier, Patient Research Partner, Boston; R.A. Luqmani, DM, FRCP, FRCP(E), Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; N. Milman, MD, MSc, FRCPC, Department of Rheumatology, University of Ottawa; J. Peck, RN, Faculty of Health and Applied Sciences, University of the West of England, Bristol and School of Clinical Sciences, University of Bristol; J.A. Shea, PhD, Division of General Internal Medicine, University of Pennsylvania; S. Carette, MD, Division of Rheumatology, Mount Sinai Hospital; N. Khalidi, MD, Division of Rheumatology, St. Joseph’s Healthcare, McMaster University; C.L. Koening, MD, Division of Rheumatology, University of Utah; C.A. Langford, MD, Department of Rheumatology, Cleveland Clinic; P.A. Monach, MD, PhD, Section of Rheumatology, Boston University School of Medicine; L. Moreland, MD, Division of Rheumatology, University of Pittsburgh; C. Pagnoux, MD, MSc, MPH, Division of Rheumatology, Mount Sinai Hospital; U. Specks, MD, Division of Pulmonology and Critical Care Medicine, Mayo Clinic College of Medicine and Science; A.G. Sreih, MD, Division of Rheumatology, University of Pennsylvania; S.R. Ytterberg, MD, Division of Rheumatology, Mayo Clinic College of Medicine and Science; P.A. Merkel, MD, MPH, Division of Rheumatology, University of Pennsylvania. Address correspondence to Dr. G. Tomasson, Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland, Sturlugata 8, 101 Reykjavik, Iceland. E-mail: gunnar.tomasson@gmail.com. Accepted for publication November 26, 2018.
David Cuthbertson
From the Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland; Department of Rheumatology, and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; Department of Biostatistics, Epidemiology, and Informatics, and Division of Rheumatology, and Department of Family Medicine and Community Health, and Division of General Internal Medicine, University of Pennsylvania, Philadelphia; Division of Rheumatology, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Biostatistics and Informatics, Department of Pediatrics, University of South Florida, Tampa, Florida; Division of Rheumatology, University of Utah, Salt Lake City, Utah; Department of Rheumatology, Cleveland Clinic, Cleveland; Ohio State University Wexner Medical Center, Columbus, Ohio; Section of Rheumatology, Boston University School of Medicine, Boston, Massachusetts; Division of Rheumatology, and Division of Pulmonology and Critical Care Medicine, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA; Nuffield Department of Population Health, Health Services Research Unit (HSRU), and Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford; Faculty of Health and Applied Sciences, University of the West of England, Bristol and School of Clinical Sciences, University of Bristol, Bristol, UK; Department of Rheumatology, University of Ottawa, Ottawa; Division of Rheumatology, Mount Sinai Hospital, Toronto; Division of Rheumatology, St. Joseph’s Healthcare, McMaster University, Hamilton, Ontario, Canada. This work was supported by The Vasculitis Clinical Research Consortium (VCRC; U54 AR057319 and R01 AR 064153), which is part of the Rare Diseases Clinical Research Network, an initiative of the US Office of Rare Diseases Research, National Center for Advancing Translational Science (NCATS). The VCRC is funded through collaboration between NCATS, and the National Institute of Arthritis and Musculoskeletal and Skin Diseases, and has received funding from the National Center for Research Resources (U54 RR019497). Additional support for this work was provided by a contract from the Patient-Centered Outcomes Research Institute (IP2PI000603). G. Tomasson, MD, PhD, Assistant Professor, Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland, and Department of Rheumatology, and Centre for Rheumatology Research, University Hospital; J.T. Farrar, MD, Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania; D. Cuthbertson, MS, Department of Biostatistics and Informatics, Department of Pediatrics, University of South Florida; C.A. McAlear, MA, Division of Rheumatology, University of Pennsylvania; S. Ashdown, RN, Oxfordshire; P.F. Cronholm, MD, MSCE, Department of Family Medicine and Community Health, University of Pennsylvania; J. Dawson, MA, MSc, DPhil, SRN, SCM, Nuffield Department of Population Health (HSRU), University of Oxford; D. Gebhart, MD, Ohio State University Wexner Medical Center, Columbus; G. Lanier, Patient Research Partner, Boston; R.A. Luqmani, DM, FRCP, FRCP(E), Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; N. Milman, MD, MSc, FRCPC, Department of Rheumatology, University of Ottawa; J. Peck, RN, Faculty of Health and Applied Sciences, University of the West of England, Bristol and School of Clinical Sciences, University of Bristol; J.A. Shea, PhD, Division of General Internal Medicine, University of Pennsylvania; S. Carette, MD, Division of Rheumatology, Mount Sinai Hospital; N. Khalidi, MD, Division of Rheumatology, St. Joseph’s Healthcare, McMaster University; C.L. Koening, MD, Division of Rheumatology, University of Utah; C.A. Langford, MD, Department of Rheumatology, Cleveland Clinic; P.A. Monach, MD, PhD, Section of Rheumatology, Boston University School of Medicine; L. Moreland, MD, Division of Rheumatology, University of Pittsburgh; C. Pagnoux, MD, MSc, MPH, Division of Rheumatology, Mount Sinai Hospital; U. Specks, MD, Division of Pulmonology and Critical Care Medicine, Mayo Clinic College of Medicine and Science; A.G. Sreih, MD, Division of Rheumatology, University of Pennsylvania; S.R. Ytterberg, MD, Division of Rheumatology, Mayo Clinic College of Medicine and Science; P.A. Merkel, MD, MPH, Division of Rheumatology, University of Pennsylvania. Address correspondence to Dr. G. Tomasson, Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland, Sturlugata 8, 101 Reykjavik, Iceland. E-mail: gunnar.tomasson@gmail.com. Accepted for publication November 26, 2018.
Carol A. McAlear
From the Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland; Department of Rheumatology, and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; Department of Biostatistics, Epidemiology, and Informatics, and Division of Rheumatology, and Department of Family Medicine and Community Health, and Division of General Internal Medicine, University of Pennsylvania, Philadelphia; Division of Rheumatology, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Biostatistics and Informatics, Department of Pediatrics, University of South Florida, Tampa, Florida; Division of Rheumatology, University of Utah, Salt Lake City, Utah; Department of Rheumatology, Cleveland Clinic, Cleveland; Ohio State University Wexner Medical Center, Columbus, Ohio; Section of Rheumatology, Boston University School of Medicine, Boston, Massachusetts; Division of Rheumatology, and Division of Pulmonology and Critical Care Medicine, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA; Nuffield Department of Population Health, Health Services Research Unit (HSRU), and Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford; Faculty of Health and Applied Sciences, University of the West of England, Bristol and School of Clinical Sciences, University of Bristol, Bristol, UK; Department of Rheumatology, University of Ottawa, Ottawa; Division of Rheumatology, Mount Sinai Hospital, Toronto; Division of Rheumatology, St. Joseph’s Healthcare, McMaster University, Hamilton, Ontario, Canada. This work was supported by The Vasculitis Clinical Research Consortium (VCRC; U54 AR057319 and R01 AR 064153), which is part of the Rare Diseases Clinical Research Network, an initiative of the US Office of Rare Diseases Research, National Center for Advancing Translational Science (NCATS). The VCRC is funded through collaboration between NCATS, and the National Institute of Arthritis and Musculoskeletal and Skin Diseases, and has received funding from the National Center for Research Resources (U54 RR019497). Additional support for this work was provided by a contract from the Patient-Centered Outcomes Research Institute (IP2PI000603). G. Tomasson, MD, PhD, Assistant Professor, Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland, and Department of Rheumatology, and Centre for Rheumatology Research, University Hospital; J.T. Farrar, MD, Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania; D. Cuthbertson, MS, Department of Biostatistics and Informatics, Department of Pediatrics, University of South Florida; C.A. McAlear, MA, Division of Rheumatology, University of Pennsylvania; S. Ashdown, RN, Oxfordshire; P.F. Cronholm, MD, MSCE, Department of Family Medicine and Community Health, University of Pennsylvania; J. Dawson, MA, MSc, DPhil, SRN, SCM, Nuffield Department of Population Health (HSRU), University of Oxford; D. Gebhart, MD, Ohio State University Wexner Medical Center, Columbus; G. Lanier, Patient Research Partner, Boston; R.A. Luqmani, DM, FRCP, FRCP(E), Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; N. Milman, MD, MSc, FRCPC, Department of Rheumatology, University of Ottawa; J. Peck, RN, Faculty of Health and Applied Sciences, University of the West of England, Bristol and School of Clinical Sciences, University of Bristol; J.A. Shea, PhD, Division of General Internal Medicine, University of Pennsylvania; S. Carette, MD, Division of Rheumatology, Mount Sinai Hospital; N. Khalidi, MD, Division of Rheumatology, St. Joseph’s Healthcare, McMaster University; C.L. Koening, MD, Division of Rheumatology, University of Utah; C.A. Langford, MD, Department of Rheumatology, Cleveland Clinic; P.A. Monach, MD, PhD, Section of Rheumatology, Boston University School of Medicine; L. Moreland, MD, Division of Rheumatology, University of Pittsburgh; C. Pagnoux, MD, MSc, MPH, Division of Rheumatology, Mount Sinai Hospital; U. Specks, MD, Division of Pulmonology and Critical Care Medicine, Mayo Clinic College of Medicine and Science; A.G. Sreih, MD, Division of Rheumatology, University of Pennsylvania; S.R. Ytterberg, MD, Division of Rheumatology, Mayo Clinic College of Medicine and Science; P.A. Merkel, MD, MPH, Division of Rheumatology, University of Pennsylvania. Address correspondence to Dr. G. Tomasson, Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland, Sturlugata 8, 101 Reykjavik, Iceland. E-mail: gunnar.tomasson@gmail.com. Accepted for publication November 26, 2018.
Susan Ashdown
From the Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland; Department of Rheumatology, and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; Department of Biostatistics, Epidemiology, and Informatics, and Division of Rheumatology, and Department of Family Medicine and Community Health, and Division of General Internal Medicine, University of Pennsylvania, Philadelphia; Division of Rheumatology, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Biostatistics and Informatics, Department of Pediatrics, University of South Florida, Tampa, Florida; Division of Rheumatology, University of Utah, Salt Lake City, Utah; Department of Rheumatology, Cleveland Clinic, Cleveland; Ohio State University Wexner Medical Center, Columbus, Ohio; Section of Rheumatology, Boston University School of Medicine, Boston, Massachusetts; Division of Rheumatology, and Division of Pulmonology and Critical Care Medicine, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA; Nuffield Department of Population Health, Health Services Research Unit (HSRU), and Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford; Faculty of Health and Applied Sciences, University of the West of England, Bristol and School of Clinical Sciences, University of Bristol, Bristol, UK; Department of Rheumatology, University of Ottawa, Ottawa; Division of Rheumatology, Mount Sinai Hospital, Toronto; Division of Rheumatology, St. Joseph’s Healthcare, McMaster University, Hamilton, Ontario, Canada. This work was supported by The Vasculitis Clinical Research Consortium (VCRC; U54 AR057319 and R01 AR 064153), which is part of the Rare Diseases Clinical Research Network, an initiative of the US Office of Rare Diseases Research, National Center for Advancing Translational Science (NCATS). The VCRC is funded through collaboration between NCATS, and the National Institute of Arthritis and Musculoskeletal and Skin Diseases, and has received funding from the National Center for Research Resources (U54 RR019497). Additional support for this work was provided by a contract from the Patient-Centered Outcomes Research Institute (IP2PI000603). G. Tomasson, MD, PhD, Assistant Professor, Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland, and Department of Rheumatology, and Centre for Rheumatology Research, University Hospital; J.T. Farrar, MD, Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania; D. Cuthbertson, MS, Department of Biostatistics and Informatics, Department of Pediatrics, University of South Florida; C.A. McAlear, MA, Division of Rheumatology, University of Pennsylvania; S. Ashdown, RN, Oxfordshire; P.F. Cronholm, MD, MSCE, Department of Family Medicine and Community Health, University of Pennsylvania; J. Dawson, MA, MSc, DPhil, SRN, SCM, Nuffield Department of Population Health (HSRU), University of Oxford; D. Gebhart, MD, Ohio State University Wexner Medical Center, Columbus; G. Lanier, Patient Research Partner, Boston; R.A. Luqmani, DM, FRCP, FRCP(E), Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; N. Milman, MD, MSc, FRCPC, Department of Rheumatology, University of Ottawa; J. Peck, RN, Faculty of Health and Applied Sciences, University of the West of England, Bristol and School of Clinical Sciences, University of Bristol; J.A. Shea, PhD, Division of General Internal Medicine, University of Pennsylvania; S. Carette, MD, Division of Rheumatology, Mount Sinai Hospital; N. Khalidi, MD, Division of Rheumatology, St. Joseph’s Healthcare, McMaster University; C.L. Koening, MD, Division of Rheumatology, University of Utah; C.A. Langford, MD, Department of Rheumatology, Cleveland Clinic; P.A. Monach, MD, PhD, Section of Rheumatology, Boston University School of Medicine; L. Moreland, MD, Division of Rheumatology, University of Pittsburgh; C. Pagnoux, MD, MSc, MPH, Division of Rheumatology, Mount Sinai Hospital; U. Specks, MD, Division of Pulmonology and Critical Care Medicine, Mayo Clinic College of Medicine and Science; A.G. Sreih, MD, Division of Rheumatology, University of Pennsylvania; S.R. Ytterberg, MD, Division of Rheumatology, Mayo Clinic College of Medicine and Science; P.A. Merkel, MD, MPH, Division of Rheumatology, University of Pennsylvania. Address correspondence to Dr. G. Tomasson, Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland, Sturlugata 8, 101 Reykjavik, Iceland. E-mail: gunnar.tomasson@gmail.com. Accepted for publication November 26, 2018.
Peter F. Cronholm
From the Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland; Department of Rheumatology, and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; Department of Biostatistics, Epidemiology, and Informatics, and Division of Rheumatology, and Department of Family Medicine and Community Health, and Division of General Internal Medicine, University of Pennsylvania, Philadelphia; Division of Rheumatology, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Biostatistics and Informatics, Department of Pediatrics, University of South Florida, Tampa, Florida; Division of Rheumatology, University of Utah, Salt Lake City, Utah; Department of Rheumatology, Cleveland Clinic, Cleveland; Ohio State University Wexner Medical Center, Columbus, Ohio; Section of Rheumatology, Boston University School of Medicine, Boston, Massachusetts; Division of Rheumatology, and Division of Pulmonology and Critical Care Medicine, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA; Nuffield Department of Population Health, Health Services Research Unit (HSRU), and Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford; Faculty of Health and Applied Sciences, University of the West of England, Bristol and School of Clinical Sciences, University of Bristol, Bristol, UK; Department of Rheumatology, University of Ottawa, Ottawa; Division of Rheumatology, Mount Sinai Hospital, Toronto; Division of Rheumatology, St. Joseph’s Healthcare, McMaster University, Hamilton, Ontario, Canada. This work was supported by The Vasculitis Clinical Research Consortium (VCRC; U54 AR057319 and R01 AR 064153), which is part of the Rare Diseases Clinical Research Network, an initiative of the US Office of Rare Diseases Research, National Center for Advancing Translational Science (NCATS). The VCRC is funded through collaboration between NCATS, and the National Institute of Arthritis and Musculoskeletal and Skin Diseases, and has received funding from the National Center for Research Resources (U54 RR019497). Additional support for this work was provided by a contract from the Patient-Centered Outcomes Research Institute (IP2PI000603). G. Tomasson, MD, PhD, Assistant Professor, Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland, and Department of Rheumatology, and Centre for Rheumatology Research, University Hospital; J.T. Farrar, MD, Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania; D. Cuthbertson, MS, Department of Biostatistics and Informatics, Department of Pediatrics, University of South Florida; C.A. McAlear, MA, Division of Rheumatology, University of Pennsylvania; S. Ashdown, RN, Oxfordshire; P.F. Cronholm, MD, MSCE, Department of Family Medicine and Community Health, University of Pennsylvania; J. Dawson, MA, MSc, DPhil, SRN, SCM, Nuffield Department of Population Health (HSRU), University of Oxford; D. Gebhart, MD, Ohio State University Wexner Medical Center, Columbus; G. Lanier, Patient Research Partner, Boston; R.A. Luqmani, DM, FRCP, FRCP(E), Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; N. Milman, MD, MSc, FRCPC, Department of Rheumatology, University of Ottawa; J. Peck, RN, Faculty of Health and Applied Sciences, University of the West of England, Bristol and School of Clinical Sciences, University of Bristol; J.A. Shea, PhD, Division of General Internal Medicine, University of Pennsylvania; S. Carette, MD, Division of Rheumatology, Mount Sinai Hospital; N. Khalidi, MD, Division of Rheumatology, St. Joseph’s Healthcare, McMaster University; C.L. Koening, MD, Division of Rheumatology, University of Utah; C.A. Langford, MD, Department of Rheumatology, Cleveland Clinic; P.A. Monach, MD, PhD, Section of Rheumatology, Boston University School of Medicine; L. Moreland, MD, Division of Rheumatology, University of Pittsburgh; C. Pagnoux, MD, MSc, MPH, Division of Rheumatology, Mount Sinai Hospital; U. Specks, MD, Division of Pulmonology and Critical Care Medicine, Mayo Clinic College of Medicine and Science; A.G. Sreih, MD, Division of Rheumatology, University of Pennsylvania; S.R. Ytterberg, MD, Division of Rheumatology, Mayo Clinic College of Medicine and Science; P.A. Merkel, MD, MPH, Division of Rheumatology, University of Pennsylvania. Address correspondence to Dr. G. Tomasson, Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland, Sturlugata 8, 101 Reykjavik, Iceland. E-mail: gunnar.tomasson@gmail.com. Accepted for publication November 26, 2018.
Jill Dawson
From the Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland; Department of Rheumatology, and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; Department of Biostatistics, Epidemiology, and Informatics, and Division of Rheumatology, and Department of Family Medicine and Community Health, and Division of General Internal Medicine, University of Pennsylvania, Philadelphia; Division of Rheumatology, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Biostatistics and Informatics, Department of Pediatrics, University of South Florida, Tampa, Florida; Division of Rheumatology, University of Utah, Salt Lake City, Utah; Department of Rheumatology, Cleveland Clinic, Cleveland; Ohio State University Wexner Medical Center, Columbus, Ohio; Section of Rheumatology, Boston University School of Medicine, Boston, Massachusetts; Division of Rheumatology, and Division of Pulmonology and Critical Care Medicine, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA; Nuffield Department of Population Health, Health Services Research Unit (HSRU), and Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford; Faculty of Health and Applied Sciences, University of the West of England, Bristol and School of Clinical Sciences, University of Bristol, Bristol, UK; Department of Rheumatology, University of Ottawa, Ottawa; Division of Rheumatology, Mount Sinai Hospital, Toronto; Division of Rheumatology, St. Joseph’s Healthcare, McMaster University, Hamilton, Ontario, Canada. This work was supported by The Vasculitis Clinical Research Consortium (VCRC; U54 AR057319 and R01 AR 064153), which is part of the Rare Diseases Clinical Research Network, an initiative of the US Office of Rare Diseases Research, National Center for Advancing Translational Science (NCATS). The VCRC is funded through collaboration between NCATS, and the National Institute of Arthritis and Musculoskeletal and Skin Diseases, and has received funding from the National Center for Research Resources (U54 RR019497). Additional support for this work was provided by a contract from the Patient-Centered Outcomes Research Institute (IP2PI000603). G. Tomasson, MD, PhD, Assistant Professor, Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland, and Department of Rheumatology, and Centre for Rheumatology Research, University Hospital; J.T. Farrar, MD, Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania; D. Cuthbertson, MS, Department of Biostatistics and Informatics, Department of Pediatrics, University of South Florida; C.A. McAlear, MA, Division of Rheumatology, University of Pennsylvania; S. Ashdown, RN, Oxfordshire; P.F. Cronholm, MD, MSCE, Department of Family Medicine and Community Health, University of Pennsylvania; J. Dawson, MA, MSc, DPhil, SRN, SCM, Nuffield Department of Population Health (HSRU), University of Oxford; D. Gebhart, MD, Ohio State University Wexner Medical Center, Columbus; G. Lanier, Patient Research Partner, Boston; R.A. Luqmani, DM, FRCP, FRCP(E), Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; N. Milman, MD, MSc, FRCPC, Department of Rheumatology, University of Ottawa; J. Peck, RN, Faculty of Health and Applied Sciences, University of the West of England, Bristol and School of Clinical Sciences, University of Bristol; J.A. Shea, PhD, Division of General Internal Medicine, University of Pennsylvania; S. Carette, MD, Division of Rheumatology, Mount Sinai Hospital; N. Khalidi, MD, Division of Rheumatology, St. Joseph’s Healthcare, McMaster University; C.L. Koening, MD, Division of Rheumatology, University of Utah; C.A. Langford, MD, Department of Rheumatology, Cleveland Clinic; P.A. Monach, MD, PhD, Section of Rheumatology, Boston University School of Medicine; L. Moreland, MD, Division of Rheumatology, University of Pittsburgh; C. Pagnoux, MD, MSc, MPH, Division of Rheumatology, Mount Sinai Hospital; U. Specks, MD, Division of Pulmonology and Critical Care Medicine, Mayo Clinic College of Medicine and Science; A.G. Sreih, MD, Division of Rheumatology, University of Pennsylvania; S.R. Ytterberg, MD, Division of Rheumatology, Mayo Clinic College of Medicine and Science; P.A. Merkel, MD, MPH, Division of Rheumatology, University of Pennsylvania. Address correspondence to Dr. G. Tomasson, Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland, Sturlugata 8, 101 Reykjavik, Iceland. E-mail: gunnar.tomasson@gmail.com. Accepted for publication November 26, 2018.
Don Gebhart
From the Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland; Department of Rheumatology, and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; Department of Biostatistics, Epidemiology, and Informatics, and Division of Rheumatology, and Department of Family Medicine and Community Health, and Division of General Internal Medicine, University of Pennsylvania, Philadelphia; Division of Rheumatology, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Biostatistics and Informatics, Department of Pediatrics, University of South Florida, Tampa, Florida; Division of Rheumatology, University of Utah, Salt Lake City, Utah; Department of Rheumatology, Cleveland Clinic, Cleveland; Ohio State University Wexner Medical Center, Columbus, Ohio; Section of Rheumatology, Boston University School of Medicine, Boston, Massachusetts; Division of Rheumatology, and Division of Pulmonology and Critical Care Medicine, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA; Nuffield Department of Population Health, Health Services Research Unit (HSRU), and Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford; Faculty of Health and Applied Sciences, University of the West of England, Bristol and School of Clinical Sciences, University of Bristol, Bristol, UK; Department of Rheumatology, University of Ottawa, Ottawa; Division of Rheumatology, Mount Sinai Hospital, Toronto; Division of Rheumatology, St. Joseph’s Healthcare, McMaster University, Hamilton, Ontario, Canada. This work was supported by The Vasculitis Clinical Research Consortium (VCRC; U54 AR057319 and R01 AR 064153), which is part of the Rare Diseases Clinical Research Network, an initiative of the US Office of Rare Diseases Research, National Center for Advancing Translational Science (NCATS). The VCRC is funded through collaboration between NCATS, and the National Institute of Arthritis and Musculoskeletal and Skin Diseases, and has received funding from the National Center for Research Resources (U54 RR019497). Additional support for this work was provided by a contract from the Patient-Centered Outcomes Research Institute (IP2PI000603). G. Tomasson, MD, PhD, Assistant Professor, Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland, and Department of Rheumatology, and Centre for Rheumatology Research, University Hospital; J.T. Farrar, MD, Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania; D. Cuthbertson, MS, Department of Biostatistics and Informatics, Department of Pediatrics, University of South Florida; C.A. McAlear, MA, Division of Rheumatology, University of Pennsylvania; S. Ashdown, RN, Oxfordshire; P.F. Cronholm, MD, MSCE, Department of Family Medicine and Community Health, University of Pennsylvania; J. Dawson, MA, MSc, DPhil, SRN, SCM, Nuffield Department of Population Health (HSRU), University of Oxford; D. Gebhart, MD, Ohio State University Wexner Medical Center, Columbus; G. Lanier, Patient Research Partner, Boston; R.A. Luqmani, DM, FRCP, FRCP(E), Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; N. Milman, MD, MSc, FRCPC, Department of Rheumatology, University of Ottawa; J. Peck, RN, Faculty of Health and Applied Sciences, University of the West of England, Bristol and School of Clinical Sciences, University of Bristol; J.A. Shea, PhD, Division of General Internal Medicine, University of Pennsylvania; S. Carette, MD, Division of Rheumatology, Mount Sinai Hospital; N. Khalidi, MD, Division of Rheumatology, St. Joseph’s Healthcare, McMaster University; C.L. Koening, MD, Division of Rheumatology, University of Utah; C.A. Langford, MD, Department of Rheumatology, Cleveland Clinic; P.A. Monach, MD, PhD, Section of Rheumatology, Boston University School of Medicine; L. Moreland, MD, Division of Rheumatology, University of Pittsburgh; C. Pagnoux, MD, MSc, MPH, Division of Rheumatology, Mount Sinai Hospital; U. Specks, MD, Division of Pulmonology and Critical Care Medicine, Mayo Clinic College of Medicine and Science; A.G. Sreih, MD, Division of Rheumatology, University of Pennsylvania; S.R. Ytterberg, MD, Division of Rheumatology, Mayo Clinic College of Medicine and Science; P.A. Merkel, MD, MPH, Division of Rheumatology, University of Pennsylvania. Address correspondence to Dr. G. Tomasson, Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland, Sturlugata 8, 101 Reykjavik, Iceland. E-mail: gunnar.tomasson@gmail.com. Accepted for publication November 26, 2018.
Georgia Lanier
From the Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland; Department of Rheumatology, and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; Department of Biostatistics, Epidemiology, and Informatics, and Division of Rheumatology, and Department of Family Medicine and Community Health, and Division of General Internal Medicine, University of Pennsylvania, Philadelphia; Division of Rheumatology, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Biostatistics and Informatics, Department of Pediatrics, University of South Florida, Tampa, Florida; Division of Rheumatology, University of Utah, Salt Lake City, Utah; Department of Rheumatology, Cleveland Clinic, Cleveland; Ohio State University Wexner Medical Center, Columbus, Ohio; Section of Rheumatology, Boston University School of Medicine, Boston, Massachusetts; Division of Rheumatology, and Division of Pulmonology and Critical Care Medicine, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA; Nuffield Department of Population Health, Health Services Research Unit (HSRU), and Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford; Faculty of Health and Applied Sciences, University of the West of England, Bristol and School of Clinical Sciences, University of Bristol, Bristol, UK; Department of Rheumatology, University of Ottawa, Ottawa; Division of Rheumatology, Mount Sinai Hospital, Toronto; Division of Rheumatology, St. Joseph’s Healthcare, McMaster University, Hamilton, Ontario, Canada. This work was supported by The Vasculitis Clinical Research Consortium (VCRC; U54 AR057319 and R01 AR 064153), which is part of the Rare Diseases Clinical Research Network, an initiative of the US Office of Rare Diseases Research, National Center for Advancing Translational Science (NCATS). The VCRC is funded through collaboration between NCATS, and the National Institute of Arthritis and Musculoskeletal and Skin Diseases, and has received funding from the National Center for Research Resources (U54 RR019497). Additional support for this work was provided by a contract from the Patient-Centered Outcomes Research Institute (IP2PI000603). G. Tomasson, MD, PhD, Assistant Professor, Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland, and Department of Rheumatology, and Centre for Rheumatology Research, University Hospital; J.T. Farrar, MD, Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania; D. Cuthbertson, MS, Department of Biostatistics and Informatics, Department of Pediatrics, University of South Florida; C.A. McAlear, MA, Division of Rheumatology, University of Pennsylvania; S. Ashdown, RN, Oxfordshire; P.F. Cronholm, MD, MSCE, Department of Family Medicine and Community Health, University of Pennsylvania; J. Dawson, MA, MSc, DPhil, SRN, SCM, Nuffield Department of Population Health (HSRU), University of Oxford; D. Gebhart, MD, Ohio State University Wexner Medical Center, Columbus; G. Lanier, Patient Research Partner, Boston; R.A. Luqmani, DM, FRCP, FRCP(E), Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; N. Milman, MD, MSc, FRCPC, Department of Rheumatology, University of Ottawa; J. Peck, RN, Faculty of Health and Applied Sciences, University of the West of England, Bristol and School of Clinical Sciences, University of Bristol; J.A. Shea, PhD, Division of General Internal Medicine, University of Pennsylvania; S. Carette, MD, Division of Rheumatology, Mount Sinai Hospital; N. Khalidi, MD, Division of Rheumatology, St. Joseph’s Healthcare, McMaster University; C.L. Koening, MD, Division of Rheumatology, University of Utah; C.A. Langford, MD, Department of Rheumatology, Cleveland Clinic; P.A. Monach, MD, PhD, Section of Rheumatology, Boston University School of Medicine; L. Moreland, MD, Division of Rheumatology, University of Pittsburgh; C. Pagnoux, MD, MSc, MPH, Division of Rheumatology, Mount Sinai Hospital; U. Specks, MD, Division of Pulmonology and Critical Care Medicine, Mayo Clinic College of Medicine and Science; A.G. Sreih, MD, Division of Rheumatology, University of Pennsylvania; S.R. Ytterberg, MD, Division of Rheumatology, Mayo Clinic College of Medicine and Science; P.A. Merkel, MD, MPH, Division of Rheumatology, University of Pennsylvania. Address correspondence to Dr. G. Tomasson, Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland, Sturlugata 8, 101 Reykjavik, Iceland. E-mail: gunnar.tomasson@gmail.com. Accepted for publication November 26, 2018.
Raashid A. Luqmani
From the Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland; Department of Rheumatology, and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; Department of Biostatistics, Epidemiology, and Informatics, and Division of Rheumatology, and Department of Family Medicine and Community Health, and Division of General Internal Medicine, University of Pennsylvania, Philadelphia; Division of Rheumatology, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Biostatistics and Informatics, Department of Pediatrics, University of South Florida, Tampa, Florida; Division of Rheumatology, University of Utah, Salt Lake City, Utah; Department of Rheumatology, Cleveland Clinic, Cleveland; Ohio State University Wexner Medical Center, Columbus, Ohio; Section of Rheumatology, Boston University School of Medicine, Boston, Massachusetts; Division of Rheumatology, and Division of Pulmonology and Critical Care Medicine, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA; Nuffield Department of Population Health, Health Services Research Unit (HSRU), and Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford; Faculty of Health and Applied Sciences, University of the West of England, Bristol and School of Clinical Sciences, University of Bristol, Bristol, UK; Department of Rheumatology, University of Ottawa, Ottawa; Division of Rheumatology, Mount Sinai Hospital, Toronto; Division of Rheumatology, St. Joseph’s Healthcare, McMaster University, Hamilton, Ontario, Canada. This work was supported by The Vasculitis Clinical Research Consortium (VCRC; U54 AR057319 and R01 AR 064153), which is part of the Rare Diseases Clinical Research Network, an initiative of the US Office of Rare Diseases Research, National Center for Advancing Translational Science (NCATS). The VCRC is funded through collaboration between NCATS, and the National Institute of Arthritis and Musculoskeletal and Skin Diseases, and has received funding from the National Center for Research Resources (U54 RR019497). Additional support for this work was provided by a contract from the Patient-Centered Outcomes Research Institute (IP2PI000603). G. Tomasson, MD, PhD, Assistant Professor, Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland, and Department of Rheumatology, and Centre for Rheumatology Research, University Hospital; J.T. Farrar, MD, Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania; D. Cuthbertson, MS, Department of Biostatistics and Informatics, Department of Pediatrics, University of South Florida; C.A. McAlear, MA, Division of Rheumatology, University of Pennsylvania; S. Ashdown, RN, Oxfordshire; P.F. Cronholm, MD, MSCE, Department of Family Medicine and Community Health, University of Pennsylvania; J. Dawson, MA, MSc, DPhil, SRN, SCM, Nuffield Department of Population Health (HSRU), University of Oxford; D. Gebhart, MD, Ohio State University Wexner Medical Center, Columbus; G. Lanier, Patient Research Partner, Boston; R.A. Luqmani, DM, FRCP, FRCP(E), Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; N. Milman, MD, MSc, FRCPC, Department of Rheumatology, University of Ottawa; J. Peck, RN, Faculty of Health and Applied Sciences, University of the West of England, Bristol and School of Clinical Sciences, University of Bristol; J.A. Shea, PhD, Division of General Internal Medicine, University of Pennsylvania; S. Carette, MD, Division of Rheumatology, Mount Sinai Hospital; N. Khalidi, MD, Division of Rheumatology, St. Joseph’s Healthcare, McMaster University; C.L. Koening, MD, Division of Rheumatology, University of Utah; C.A. Langford, MD, Department of Rheumatology, Cleveland Clinic; P.A. Monach, MD, PhD, Section of Rheumatology, Boston University School of Medicine; L. Moreland, MD, Division of Rheumatology, University of Pittsburgh; C. Pagnoux, MD, MSc, MPH, Division of Rheumatology, Mount Sinai Hospital; U. Specks, MD, Division of Pulmonology and Critical Care Medicine, Mayo Clinic College of Medicine and Science; A.G. Sreih, MD, Division of Rheumatology, University of Pennsylvania; S.R. Ytterberg, MD, Division of Rheumatology, Mayo Clinic College of Medicine and Science; P.A. Merkel, MD, MPH, Division of Rheumatology, University of Pennsylvania. Address correspondence to Dr. G. Tomasson, Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland, Sturlugata 8, 101 Reykjavik, Iceland. E-mail: gunnar.tomasson@gmail.com. Accepted for publication November 26, 2018.
Nataliya Milman
From the Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland; Department of Rheumatology, and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; Department of Biostatistics, Epidemiology, and Informatics, and Division of Rheumatology, and Department of Family Medicine and Community Health, and Division of General Internal Medicine, University of Pennsylvania, Philadelphia; Division of Rheumatology, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Biostatistics and Informatics, Department of Pediatrics, University of South Florida, Tampa, Florida; Division of Rheumatology, University of Utah, Salt Lake City, Utah; Department of Rheumatology, Cleveland Clinic, Cleveland; Ohio State University Wexner Medical Center, Columbus, Ohio; Section of Rheumatology, Boston University School of Medicine, Boston, Massachusetts; Division of Rheumatology, and Division of Pulmonology and Critical Care Medicine, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA; Nuffield Department of Population Health, Health Services Research Unit (HSRU), and Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford; Faculty of Health and Applied Sciences, University of the West of England, Bristol and School of Clinical Sciences, University of Bristol, Bristol, UK; Department of Rheumatology, University of Ottawa, Ottawa; Division of Rheumatology, Mount Sinai Hospital, Toronto; Division of Rheumatology, St. Joseph’s Healthcare, McMaster University, Hamilton, Ontario, Canada. This work was supported by The Vasculitis Clinical Research Consortium (VCRC; U54 AR057319 and R01 AR 064153), which is part of the Rare Diseases Clinical Research Network, an initiative of the US Office of Rare Diseases Research, National Center for Advancing Translational Science (NCATS). The VCRC is funded through collaboration between NCATS, and the National Institute of Arthritis and Musculoskeletal and Skin Diseases, and has received funding from the National Center for Research Resources (U54 RR019497). Additional support for this work was provided by a contract from the Patient-Centered Outcomes Research Institute (IP2PI000603). G. Tomasson, MD, PhD, Assistant Professor, Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland, and Department of Rheumatology, and Centre for Rheumatology Research, University Hospital; J.T. Farrar, MD, Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania; D. Cuthbertson, MS, Department of Biostatistics and Informatics, Department of Pediatrics, University of South Florida; C.A. McAlear, MA, Division of Rheumatology, University of Pennsylvania; S. Ashdown, RN, Oxfordshire; P.F. Cronholm, MD, MSCE, Department of Family Medicine and Community Health, University of Pennsylvania; J. Dawson, MA, MSc, DPhil, SRN, SCM, Nuffield Department of Population Health (HSRU), University of Oxford; D. Gebhart, MD, Ohio State University Wexner Medical Center, Columbus; G. Lanier, Patient Research Partner, Boston; R.A. Luqmani, DM, FRCP, FRCP(E), Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; N. Milman, MD, MSc, FRCPC, Department of Rheumatology, University of Ottawa; J. Peck, RN, Faculty of Health and Applied Sciences, University of the West of England, Bristol and School of Clinical Sciences, University of Bristol; J.A. Shea, PhD, Division of General Internal Medicine, University of Pennsylvania; S. Carette, MD, Division of Rheumatology, Mount Sinai Hospital; N. Khalidi, MD, Division of Rheumatology, St. Joseph’s Healthcare, McMaster University; C.L. Koening, MD, Division of Rheumatology, University of Utah; C.A. Langford, MD, Department of Rheumatology, Cleveland Clinic; P.A. Monach, MD, PhD, Section of Rheumatology, Boston University School of Medicine; L. Moreland, MD, Division of Rheumatology, University of Pittsburgh; C. Pagnoux, MD, MSc, MPH, Division of Rheumatology, Mount Sinai Hospital; U. Specks, MD, Division of Pulmonology and Critical Care Medicine, Mayo Clinic College of Medicine and Science; A.G. Sreih, MD, Division of Rheumatology, University of Pennsylvania; S.R. Ytterberg, MD, Division of Rheumatology, Mayo Clinic College of Medicine and Science; P.A. Merkel, MD, MPH, Division of Rheumatology, University of Pennsylvania. Address correspondence to Dr. G. Tomasson, Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland, Sturlugata 8, 101 Reykjavik, Iceland. E-mail: gunnar.tomasson@gmail.com. Accepted for publication November 26, 2018.
Jacqueline Peck
From the Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland; Department of Rheumatology, and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; Department of Biostatistics, Epidemiology, and Informatics, and Division of Rheumatology, and Department of Family Medicine and Community Health, and Division of General Internal Medicine, University of Pennsylvania, Philadelphia; Division of Rheumatology, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Biostatistics and Informatics, Department of Pediatrics, University of South Florida, Tampa, Florida; Division of Rheumatology, University of Utah, Salt Lake City, Utah; Department of Rheumatology, Cleveland Clinic, Cleveland; Ohio State University Wexner Medical Center, Columbus, Ohio; Section of Rheumatology, Boston University School of Medicine, Boston, Massachusetts; Division of Rheumatology, and Division of Pulmonology and Critical Care Medicine, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA; Nuffield Department of Population Health, Health Services Research Unit (HSRU), and Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford; Faculty of Health and Applied Sciences, University of the West of England, Bristol and School of Clinical Sciences, University of Bristol, Bristol, UK; Department of Rheumatology, University of Ottawa, Ottawa; Division of Rheumatology, Mount Sinai Hospital, Toronto; Division of Rheumatology, St. Joseph’s Healthcare, McMaster University, Hamilton, Ontario, Canada. This work was supported by The Vasculitis Clinical Research Consortium (VCRC; U54 AR057319 and R01 AR 064153), which is part of the Rare Diseases Clinical Research Network, an initiative of the US Office of Rare Diseases Research, National Center for Advancing Translational Science (NCATS). The VCRC is funded through collaboration between NCATS, and the National Institute of Arthritis and Musculoskeletal and Skin Diseases, and has received funding from the National Center for Research Resources (U54 RR019497). Additional support for this work was provided by a contract from the Patient-Centered Outcomes Research Institute (IP2PI000603). G. Tomasson, MD, PhD, Assistant Professor, Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland, and Department of Rheumatology, and Centre for Rheumatology Research, University Hospital; J.T. Farrar, MD, Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania; D. Cuthbertson, MS, Department of Biostatistics and Informatics, Department of Pediatrics, University of South Florida; C.A. McAlear, MA, Division of Rheumatology, University of Pennsylvania; S. Ashdown, RN, Oxfordshire; P.F. Cronholm, MD, MSCE, Department of Family Medicine and Community Health, University of Pennsylvania; J. Dawson, MA, MSc, DPhil, SRN, SCM, Nuffield Department of Population Health (HSRU), University of Oxford; D. Gebhart, MD, Ohio State University Wexner Medical Center, Columbus; G. Lanier, Patient Research Partner, Boston; R.A. Luqmani, DM, FRCP, FRCP(E), Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; N. Milman, MD, MSc, FRCPC, Department of Rheumatology, University of Ottawa; J. Peck, RN, Faculty of Health and Applied Sciences, University of the West of England, Bristol and School of Clinical Sciences, University of Bristol; J.A. Shea, PhD, Division of General Internal Medicine, University of Pennsylvania; S. Carette, MD, Division of Rheumatology, Mount Sinai Hospital; N. Khalidi, MD, Division of Rheumatology, St. Joseph’s Healthcare, McMaster University; C.L. Koening, MD, Division of Rheumatology, University of Utah; C.A. Langford, MD, Department of Rheumatology, Cleveland Clinic; P.A. Monach, MD, PhD, Section of Rheumatology, Boston University School of Medicine; L. Moreland, MD, Division of Rheumatology, University of Pittsburgh; C. Pagnoux, MD, MSc, MPH, Division of Rheumatology, Mount Sinai Hospital; U. Specks, MD, Division of Pulmonology and Critical Care Medicine, Mayo Clinic College of Medicine and Science; A.G. Sreih, MD, Division of Rheumatology, University of Pennsylvania; S.R. Ytterberg, MD, Division of Rheumatology, Mayo Clinic College of Medicine and Science; P.A. Merkel, MD, MPH, Division of Rheumatology, University of Pennsylvania. Address correspondence to Dr. G. Tomasson, Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland, Sturlugata 8, 101 Reykjavik, Iceland. E-mail: gunnar.tomasson@gmail.com. Accepted for publication November 26, 2018.
Joanna C. Robson
From the Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland; Department of Rheumatology, and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; Department of Biostatistics, Epidemiology, and Informatics, and Division of Rheumatology, and Department of Family Medicine and Community Health, and Division of General Internal Medicine, University of Pennsylvania, Philadelphia; Division of Rheumatology, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Biostatistics and Informatics, Department of Pediatrics, University of South Florida, Tampa, Florida; Division of Rheumatology, University of Utah, Salt Lake City, Utah; Department of Rheumatology, Cleveland Clinic, Cleveland; Ohio State University Wexner Medical Center, Columbus, Ohio; Section of Rheumatology, Boston University School of Medicine, Boston, Massachusetts; Division of Rheumatology, and Division of Pulmonology and Critical Care Medicine, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA; Nuffield Department of Population Health, Health Services Research Unit (HSRU), and Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford; Faculty of Health and Applied Sciences, University of the West of England, Bristol and School of Clinical Sciences, University of Bristol, Bristol, UK; Department of Rheumatology, University of Ottawa, Ottawa; Division of Rheumatology, Mount Sinai Hospital, Toronto; Division of Rheumatology, St. Joseph’s Healthcare, McMaster University, Hamilton, Ontario, Canada. This work was supported by The Vasculitis Clinical Research Consortium (VCRC; U54 AR057319 and R01 AR 064153), which is part of the Rare Diseases Clinical Research Network, an initiative of the US Office of Rare Diseases Research, National Center for Advancing Translational Science (NCATS). The VCRC is funded through collaboration between NCATS, and the National Institute of Arthritis and Musculoskeletal and Skin Diseases, and has received funding from the National Center for Research Resources (U54 RR019497). Additional support for this work was provided by a contract from the Patient-Centered Outcomes Research Institute (IP2PI000603). G. Tomasson, MD, PhD, Assistant Professor, Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland, and Department of Rheumatology, and Centre for Rheumatology Research, University Hospital; J.T. Farrar, MD, Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania; D. Cuthbertson, MS, Department of Biostatistics and Informatics, Department of Pediatrics, University of South Florida; C.A. McAlear, MA, Division of Rheumatology, University of Pennsylvania; S. Ashdown, RN, Oxfordshire; P.F. Cronholm, MD, MSCE, Department of Family Medicine and Community Health, University of Pennsylvania; J. Dawson, MA, MSc, DPhil, SRN, SCM, Nuffield Department of Population Health (HSRU), University of Oxford; D. Gebhart, MD, Ohio State University Wexner Medical Center, Columbus; G. Lanier, Patient Research Partner, Boston; R.A. Luqmani, DM, FRCP, FRCP(E), Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; N. Milman, MD, MSc, FRCPC, Department of Rheumatology, University of Ottawa; J. Peck, RN, Faculty of Health and Applied Sciences, University of the West of England, Bristol and School of Clinical Sciences, University of Bristol; J.A. Shea, PhD, Division of General Internal Medicine, University of Pennsylvania; S. Carette, MD, Division of Rheumatology, Mount Sinai Hospital; N. Khalidi, MD, Division of Rheumatology, St. Joseph’s Healthcare, McMaster University; C.L. Koening, MD, Division of Rheumatology, University of Utah; C.A. Langford, MD, Department of Rheumatology, Cleveland Clinic; P.A. Monach, MD, PhD, Section of Rheumatology, Boston University School of Medicine; L. Moreland, MD, Division of Rheumatology, University of Pittsburgh; C. Pagnoux, MD, MSc, MPH, Division of Rheumatology, Mount Sinai Hospital; U. Specks, MD, Division of Pulmonology and Critical Care Medicine, Mayo Clinic College of Medicine and Science; A.G. Sreih, MD, Division of Rheumatology, University of Pennsylvania; S.R. Ytterberg, MD, Division of Rheumatology, Mayo Clinic College of Medicine and Science; P.A. Merkel, MD, MPH, Division of Rheumatology, University of Pennsylvania. Address correspondence to Dr. G. Tomasson, Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland, Sturlugata 8, 101 Reykjavik, Iceland. E-mail: gunnar.tomasson@gmail.com. Accepted for publication November 26, 2018.
Judy A. Shea
From the Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland; Department of Rheumatology, and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; Department of Biostatistics, Epidemiology, and Informatics, and Division of Rheumatology, and Department of Family Medicine and Community Health, and Division of General Internal Medicine, University of Pennsylvania, Philadelphia; Division of Rheumatology, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Biostatistics and Informatics, Department of Pediatrics, University of South Florida, Tampa, Florida; Division of Rheumatology, University of Utah, Salt Lake City, Utah; Department of Rheumatology, Cleveland Clinic, Cleveland; Ohio State University Wexner Medical Center, Columbus, Ohio; Section of Rheumatology, Boston University School of Medicine, Boston, Massachusetts; Division of Rheumatology, and Division of Pulmonology and Critical Care Medicine, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA; Nuffield Department of Population Health, Health Services Research Unit (HSRU), and Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford; Faculty of Health and Applied Sciences, University of the West of England, Bristol and School of Clinical Sciences, University of Bristol, Bristol, UK; Department of Rheumatology, University of Ottawa, Ottawa; Division of Rheumatology, Mount Sinai Hospital, Toronto; Division of Rheumatology, St. Joseph’s Healthcare, McMaster University, Hamilton, Ontario, Canada. This work was supported by The Vasculitis Clinical Research Consortium (VCRC; U54 AR057319 and R01 AR 064153), which is part of the Rare Diseases Clinical Research Network, an initiative of the US Office of Rare Diseases Research, National Center for Advancing Translational Science (NCATS). The VCRC is funded through collaboration between NCATS, and the National Institute of Arthritis and Musculoskeletal and Skin Diseases, and has received funding from the National Center for Research Resources (U54 RR019497). Additional support for this work was provided by a contract from the Patient-Centered Outcomes Research Institute (IP2PI000603). G. Tomasson, MD, PhD, Assistant Professor, Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland, and Department of Rheumatology, and Centre for Rheumatology Research, University Hospital; J.T. Farrar, MD, Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania; D. Cuthbertson, MS, Department of Biostatistics and Informatics, Department of Pediatrics, University of South Florida; C.A. McAlear, MA, Division of Rheumatology, University of Pennsylvania; S. Ashdown, RN, Oxfordshire; P.F. Cronholm, MD, MSCE, Department of Family Medicine and Community Health, University of Pennsylvania; J. Dawson, MA, MSc, DPhil, SRN, SCM, Nuffield Department of Population Health (HSRU), University of Oxford; D. Gebhart, MD, Ohio State University Wexner Medical Center, Columbus; G. Lanier, Patient Research Partner, Boston; R.A. Luqmani, DM, FRCP, FRCP(E), Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; N. Milman, MD, MSc, FRCPC, Department of Rheumatology, University of Ottawa; J. Peck, RN, Faculty of Health and Applied Sciences, University of the West of England, Bristol and School of Clinical Sciences, University of Bristol; J.A. Shea, PhD, Division of General Internal Medicine, University of Pennsylvania; S. Carette, MD, Division of Rheumatology, Mount Sinai Hospital; N. Khalidi, MD, Division of Rheumatology, St. Joseph’s Healthcare, McMaster University; C.L. Koening, MD, Division of Rheumatology, University of Utah; C.A. Langford, MD, Department of Rheumatology, Cleveland Clinic; P.A. Monach, MD, PhD, Section of Rheumatology, Boston University School of Medicine; L. Moreland, MD, Division of Rheumatology, University of Pittsburgh; C. Pagnoux, MD, MSc, MPH, Division of Rheumatology, Mount Sinai Hospital; U. Specks, MD, Division of Pulmonology and Critical Care Medicine, Mayo Clinic College of Medicine and Science; A.G. Sreih, MD, Division of Rheumatology, University of Pennsylvania; S.R. Ytterberg, MD, Division of Rheumatology, Mayo Clinic College of Medicine and Science; P.A. Merkel, MD, MPH, Division of Rheumatology, University of Pennsylvania. Address correspondence to Dr. G. Tomasson, Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland, Sturlugata 8, 101 Reykjavik, Iceland. E-mail: gunnar.tomasson@gmail.com. Accepted for publication November 26, 2018.
Simon Carette
From the Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland; Department of Rheumatology, and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; Department of Biostatistics, Epidemiology, and Informatics, and Division of Rheumatology, and Department of Family Medicine and Community Health, and Division of General Internal Medicine, University of Pennsylvania, Philadelphia; Division of Rheumatology, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Biostatistics and Informatics, Department of Pediatrics, University of South Florida, Tampa, Florida; Division of Rheumatology, University of Utah, Salt Lake City, Utah; Department of Rheumatology, Cleveland Clinic, Cleveland; Ohio State University Wexner Medical Center, Columbus, Ohio; Section of Rheumatology, Boston University School of Medicine, Boston, Massachusetts; Division of Rheumatology, and Division of Pulmonology and Critical Care Medicine, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA; Nuffield Department of Population Health, Health Services Research Unit (HSRU), and Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford; Faculty of Health and Applied Sciences, University of the West of England, Bristol and School of Clinical Sciences, University of Bristol, Bristol, UK; Department of Rheumatology, University of Ottawa, Ottawa; Division of Rheumatology, Mount Sinai Hospital, Toronto; Division of Rheumatology, St. Joseph’s Healthcare, McMaster University, Hamilton, Ontario, Canada. This work was supported by The Vasculitis Clinical Research Consortium (VCRC; U54 AR057319 and R01 AR 064153), which is part of the Rare Diseases Clinical Research Network, an initiative of the US Office of Rare Diseases Research, National Center for Advancing Translational Science (NCATS). The VCRC is funded through collaboration between NCATS, and the National Institute of Arthritis and Musculoskeletal and Skin Diseases, and has received funding from the National Center for Research Resources (U54 RR019497). Additional support for this work was provided by a contract from the Patient-Centered Outcomes Research Institute (IP2PI000603). G. Tomasson, MD, PhD, Assistant Professor, Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland, and Department of Rheumatology, and Centre for Rheumatology Research, University Hospital; J.T. Farrar, MD, Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania; D. Cuthbertson, MS, Department of Biostatistics and Informatics, Department of Pediatrics, University of South Florida; C.A. McAlear, MA, Division of Rheumatology, University of Pennsylvania; S. Ashdown, RN, Oxfordshire; P.F. Cronholm, MD, MSCE, Department of Family Medicine and Community Health, University of Pennsylvania; J. Dawson, MA, MSc, DPhil, SRN, SCM, Nuffield Department of Population Health (HSRU), University of Oxford; D. Gebhart, MD, Ohio State University Wexner Medical Center, Columbus; G. Lanier, Patient Research Partner, Boston; R.A. Luqmani, DM, FRCP, FRCP(E), Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; N. Milman, MD, MSc, FRCPC, Department of Rheumatology, University of Ottawa; J. Peck, RN, Faculty of Health and Applied Sciences, University of the West of England, Bristol and School of Clinical Sciences, University of Bristol; J.A. Shea, PhD, Division of General Internal Medicine, University of Pennsylvania; S. Carette, MD, Division of Rheumatology, Mount Sinai Hospital; N. Khalidi, MD, Division of Rheumatology, St. Joseph’s Healthcare, McMaster University; C.L. Koening, MD, Division of Rheumatology, University of Utah; C.A. Langford, MD, Department of Rheumatology, Cleveland Clinic; P.A. Monach, MD, PhD, Section of Rheumatology, Boston University School of Medicine; L. Moreland, MD, Division of Rheumatology, University of Pittsburgh; C. Pagnoux, MD, MSc, MPH, Division of Rheumatology, Mount Sinai Hospital; U. Specks, MD, Division of Pulmonology and Critical Care Medicine, Mayo Clinic College of Medicine and Science; A.G. Sreih, MD, Division of Rheumatology, University of Pennsylvania; S.R. Ytterberg, MD, Division of Rheumatology, Mayo Clinic College of Medicine and Science; P.A. Merkel, MD, MPH, Division of Rheumatology, University of Pennsylvania. Address correspondence to Dr. G. Tomasson, Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland, Sturlugata 8, 101 Reykjavik, Iceland. E-mail: gunnar.tomasson@gmail.com. Accepted for publication November 26, 2018.
Nader Khalidi
From the Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland; Department of Rheumatology, and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; Department of Biostatistics, Epidemiology, and Informatics, and Division of Rheumatology, and Department of Family Medicine and Community Health, and Division of General Internal Medicine, University of Pennsylvania, Philadelphia; Division of Rheumatology, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Biostatistics and Informatics, Department of Pediatrics, University of South Florida, Tampa, Florida; Division of Rheumatology, University of Utah, Salt Lake City, Utah; Department of Rheumatology, Cleveland Clinic, Cleveland; Ohio State University Wexner Medical Center, Columbus, Ohio; Section of Rheumatology, Boston University School of Medicine, Boston, Massachusetts; Division of Rheumatology, and Division of Pulmonology and Critical Care Medicine, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA; Nuffield Department of Population Health, Health Services Research Unit (HSRU), and Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford; Faculty of Health and Applied Sciences, University of the West of England, Bristol and School of Clinical Sciences, University of Bristol, Bristol, UK; Department of Rheumatology, University of Ottawa, Ottawa; Division of Rheumatology, Mount Sinai Hospital, Toronto; Division of Rheumatology, St. Joseph’s Healthcare, McMaster University, Hamilton, Ontario, Canada. This work was supported by The Vasculitis Clinical Research Consortium (VCRC; U54 AR057319 and R01 AR 064153), which is part of the Rare Diseases Clinical Research Network, an initiative of the US Office of Rare Diseases Research, National Center for Advancing Translational Science (NCATS). The VCRC is funded through collaboration between NCATS, and the National Institute of Arthritis and Musculoskeletal and Skin Diseases, and has received funding from the National Center for Research Resources (U54 RR019497). Additional support for this work was provided by a contract from the Patient-Centered Outcomes Research Institute (IP2PI000603). G. Tomasson, MD, PhD, Assistant Professor, Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland, and Department of Rheumatology, and Centre for Rheumatology Research, University Hospital; J.T. Farrar, MD, Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania; D. Cuthbertson, MS, Department of Biostatistics and Informatics, Department of Pediatrics, University of South Florida; C.A. McAlear, MA, Division of Rheumatology, University of Pennsylvania; S. Ashdown, RN, Oxfordshire; P.F. Cronholm, MD, MSCE, Department of Family Medicine and Community Health, University of Pennsylvania; J. Dawson, MA, MSc, DPhil, SRN, SCM, Nuffield Department of Population Health (HSRU), University of Oxford; D. Gebhart, MD, Ohio State University Wexner Medical Center, Columbus; G. Lanier, Patient Research Partner, Boston; R.A. Luqmani, DM, FRCP, FRCP(E), Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; N. Milman, MD, MSc, FRCPC, Department of Rheumatology, University of Ottawa; J. Peck, RN, Faculty of Health and Applied Sciences, University of the West of England, Bristol and School of Clinical Sciences, University of Bristol; J.A. Shea, PhD, Division of General Internal Medicine, University of Pennsylvania; S. Carette, MD, Division of Rheumatology, Mount Sinai Hospital; N. Khalidi, MD, Division of Rheumatology, St. Joseph’s Healthcare, McMaster University; C.L. Koening, MD, Division of Rheumatology, University of Utah; C.A. Langford, MD, Department of Rheumatology, Cleveland Clinic; P.A. Monach, MD, PhD, Section of Rheumatology, Boston University School of Medicine; L. Moreland, MD, Division of Rheumatology, University of Pittsburgh; C. Pagnoux, MD, MSc, MPH, Division of Rheumatology, Mount Sinai Hospital; U. Specks, MD, Division of Pulmonology and Critical Care Medicine, Mayo Clinic College of Medicine and Science; A.G. Sreih, MD, Division of Rheumatology, University of Pennsylvania; S.R. Ytterberg, MD, Division of Rheumatology, Mayo Clinic College of Medicine and Science; P.A. Merkel, MD, MPH, Division of Rheumatology, University of Pennsylvania. Address correspondence to Dr. G. Tomasson, Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland, Sturlugata 8, 101 Reykjavik, Iceland. E-mail: gunnar.tomasson@gmail.com. Accepted for publication November 26, 2018.
Curry L. Koening
From the Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland; Department of Rheumatology, and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; Department of Biostatistics, Epidemiology, and Informatics, and Division of Rheumatology, and Department of Family Medicine and Community Health, and Division of General Internal Medicine, University of Pennsylvania, Philadelphia; Division of Rheumatology, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Biostatistics and Informatics, Department of Pediatrics, University of South Florida, Tampa, Florida; Division of Rheumatology, University of Utah, Salt Lake City, Utah; Department of Rheumatology, Cleveland Clinic, Cleveland; Ohio State University Wexner Medical Center, Columbus, Ohio; Section of Rheumatology, Boston University School of Medicine, Boston, Massachusetts; Division of Rheumatology, and Division of Pulmonology and Critical Care Medicine, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA; Nuffield Department of Population Health, Health Services Research Unit (HSRU), and Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford; Faculty of Health and Applied Sciences, University of the West of England, Bristol and School of Clinical Sciences, University of Bristol, Bristol, UK; Department of Rheumatology, University of Ottawa, Ottawa; Division of Rheumatology, Mount Sinai Hospital, Toronto; Division of Rheumatology, St. Joseph’s Healthcare, McMaster University, Hamilton, Ontario, Canada. This work was supported by The Vasculitis Clinical Research Consortium (VCRC; U54 AR057319 and R01 AR 064153), which is part of the Rare Diseases Clinical Research Network, an initiative of the US Office of Rare Diseases Research, National Center for Advancing Translational Science (NCATS). The VCRC is funded through collaboration between NCATS, and the National Institute of Arthritis and Musculoskeletal and Skin Diseases, and has received funding from the National Center for Research Resources (U54 RR019497). Additional support for this work was provided by a contract from the Patient-Centered Outcomes Research Institute (IP2PI000603). G. Tomasson, MD, PhD, Assistant Professor, Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland, and Department of Rheumatology, and Centre for Rheumatology Research, University Hospital; J.T. Farrar, MD, Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania; D. Cuthbertson, MS, Department of Biostatistics and Informatics, Department of Pediatrics, University of South Florida; C.A. McAlear, MA, Division of Rheumatology, University of Pennsylvania; S. Ashdown, RN, Oxfordshire; P.F. Cronholm, MD, MSCE, Department of Family Medicine and Community Health, University of Pennsylvania; J. Dawson, MA, MSc, DPhil, SRN, SCM, Nuffield Department of Population Health (HSRU), University of Oxford; D. Gebhart, MD, Ohio State University Wexner Medical Center, Columbus; G. Lanier, Patient Research Partner, Boston; R.A. Luqmani, DM, FRCP, FRCP(E), Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; N. Milman, MD, MSc, FRCPC, Department of Rheumatology, University of Ottawa; J. Peck, RN, Faculty of Health and Applied Sciences, University of the West of England, Bristol and School of Clinical Sciences, University of Bristol; J.A. Shea, PhD, Division of General Internal Medicine, University of Pennsylvania; S. Carette, MD, Division of Rheumatology, Mount Sinai Hospital; N. Khalidi, MD, Division of Rheumatology, St. Joseph’s Healthcare, McMaster University; C.L. Koening, MD, Division of Rheumatology, University of Utah; C.A. Langford, MD, Department of Rheumatology, Cleveland Clinic; P.A. Monach, MD, PhD, Section of Rheumatology, Boston University School of Medicine; L. Moreland, MD, Division of Rheumatology, University of Pittsburgh; C. Pagnoux, MD, MSc, MPH, Division of Rheumatology, Mount Sinai Hospital; U. Specks, MD, Division of Pulmonology and Critical Care Medicine, Mayo Clinic College of Medicine and Science; A.G. Sreih, MD, Division of Rheumatology, University of Pennsylvania; S.R. Ytterberg, MD, Division of Rheumatology, Mayo Clinic College of Medicine and Science; P.A. Merkel, MD, MPH, Division of Rheumatology, University of Pennsylvania. Address correspondence to Dr. G. Tomasson, Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland, Sturlugata 8, 101 Reykjavik, Iceland. E-mail: gunnar.tomasson@gmail.com. Accepted for publication November 26, 2018.
Carol A. Langford
From the Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland; Department of Rheumatology, and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; Department of Biostatistics, Epidemiology, and Informatics, and Division of Rheumatology, and Department of Family Medicine and Community Health, and Division of General Internal Medicine, University of Pennsylvania, Philadelphia; Division of Rheumatology, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Biostatistics and Informatics, Department of Pediatrics, University of South Florida, Tampa, Florida; Division of Rheumatology, University of Utah, Salt Lake City, Utah; Department of Rheumatology, Cleveland Clinic, Cleveland; Ohio State University Wexner Medical Center, Columbus, Ohio; Section of Rheumatology, Boston University School of Medicine, Boston, Massachusetts; Division of Rheumatology, and Division of Pulmonology and Critical Care Medicine, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA; Nuffield Department of Population Health, Health Services Research Unit (HSRU), and Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford; Faculty of Health and Applied Sciences, University of the West of England, Bristol and School of Clinical Sciences, University of Bristol, Bristol, UK; Department of Rheumatology, University of Ottawa, Ottawa; Division of Rheumatology, Mount Sinai Hospital, Toronto; Division of Rheumatology, St. Joseph’s Healthcare, McMaster University, Hamilton, Ontario, Canada. This work was supported by The Vasculitis Clinical Research Consortium (VCRC; U54 AR057319 and R01 AR 064153), which is part of the Rare Diseases Clinical Research Network, an initiative of the US Office of Rare Diseases Research, National Center for Advancing Translational Science (NCATS). The VCRC is funded through collaboration between NCATS, and the National Institute of Arthritis and Musculoskeletal and Skin Diseases, and has received funding from the National Center for Research Resources (U54 RR019497). Additional support for this work was provided by a contract from the Patient-Centered Outcomes Research Institute (IP2PI000603). G. Tomasson, MD, PhD, Assistant Professor, Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland, and Department of Rheumatology, and Centre for Rheumatology Research, University Hospital; J.T. Farrar, MD, Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania; D. Cuthbertson, MS, Department of Biostatistics and Informatics, Department of Pediatrics, University of South Florida; C.A. McAlear, MA, Division of Rheumatology, University of Pennsylvania; S. Ashdown, RN, Oxfordshire; P.F. Cronholm, MD, MSCE, Department of Family Medicine and Community Health, University of Pennsylvania; J. Dawson, MA, MSc, DPhil, SRN, SCM, Nuffield Department of Population Health (HSRU), University of Oxford; D. Gebhart, MD, Ohio State University Wexner Medical Center, Columbus; G. Lanier, Patient Research Partner, Boston; R.A. Luqmani, DM, FRCP, FRCP(E), Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; N. Milman, MD, MSc, FRCPC, Department of Rheumatology, University of Ottawa; J. Peck, RN, Faculty of Health and Applied Sciences, University of the West of England, Bristol and School of Clinical Sciences, University of Bristol; J.A. Shea, PhD, Division of General Internal Medicine, University of Pennsylvania; S. Carette, MD, Division of Rheumatology, Mount Sinai Hospital; N. Khalidi, MD, Division of Rheumatology, St. Joseph’s Healthcare, McMaster University; C.L. Koening, MD, Division of Rheumatology, University of Utah; C.A. Langford, MD, Department of Rheumatology, Cleveland Clinic; P.A. Monach, MD, PhD, Section of Rheumatology, Boston University School of Medicine; L. Moreland, MD, Division of Rheumatology, University of Pittsburgh; C. Pagnoux, MD, MSc, MPH, Division of Rheumatology, Mount Sinai Hospital; U. Specks, MD, Division of Pulmonology and Critical Care Medicine, Mayo Clinic College of Medicine and Science; A.G. Sreih, MD, Division of Rheumatology, University of Pennsylvania; S.R. Ytterberg, MD, Division of Rheumatology, Mayo Clinic College of Medicine and Science; P.A. Merkel, MD, MPH, Division of Rheumatology, University of Pennsylvania. Address correspondence to Dr. G. Tomasson, Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland, Sturlugata 8, 101 Reykjavik, Iceland. E-mail: gunnar.tomasson@gmail.com. Accepted for publication November 26, 2018.
Paul A. Monach
From the Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland; Department of Rheumatology, and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; Department of Biostatistics, Epidemiology, and Informatics, and Division of Rheumatology, and Department of Family Medicine and Community Health, and Division of General Internal Medicine, University of Pennsylvania, Philadelphia; Division of Rheumatology, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Biostatistics and Informatics, Department of Pediatrics, University of South Florida, Tampa, Florida; Division of Rheumatology, University of Utah, Salt Lake City, Utah; Department of Rheumatology, Cleveland Clinic, Cleveland; Ohio State University Wexner Medical Center, Columbus, Ohio; Section of Rheumatology, Boston University School of Medicine, Boston, Massachusetts; Division of Rheumatology, and Division of Pulmonology and Critical Care Medicine, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA; Nuffield Department of Population Health, Health Services Research Unit (HSRU), and Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford; Faculty of Health and Applied Sciences, University of the West of England, Bristol and School of Clinical Sciences, University of Bristol, Bristol, UK; Department of Rheumatology, University of Ottawa, Ottawa; Division of Rheumatology, Mount Sinai Hospital, Toronto; Division of Rheumatology, St. Joseph’s Healthcare, McMaster University, Hamilton, Ontario, Canada. This work was supported by The Vasculitis Clinical Research Consortium (VCRC; U54 AR057319 and R01 AR 064153), which is part of the Rare Diseases Clinical Research Network, an initiative of the US Office of Rare Diseases Research, National Center for Advancing Translational Science (NCATS). The VCRC is funded through collaboration between NCATS, and the National Institute of Arthritis and Musculoskeletal and Skin Diseases, and has received funding from the National Center for Research Resources (U54 RR019497). Additional support for this work was provided by a contract from the Patient-Centered Outcomes Research Institute (IP2PI000603). G. Tomasson, MD, PhD, Assistant Professor, Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland, and Department of Rheumatology, and Centre for Rheumatology Research, University Hospital; J.T. Farrar, MD, Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania; D. Cuthbertson, MS, Department of Biostatistics and Informatics, Department of Pediatrics, University of South Florida; C.A. McAlear, MA, Division of Rheumatology, University of Pennsylvania; S. Ashdown, RN, Oxfordshire; P.F. Cronholm, MD, MSCE, Department of Family Medicine and Community Health, University of Pennsylvania; J. Dawson, MA, MSc, DPhil, SRN, SCM, Nuffield Department of Population Health (HSRU), University of Oxford; D. Gebhart, MD, Ohio State University Wexner Medical Center, Columbus; G. Lanier, Patient Research Partner, Boston; R.A. Luqmani, DM, FRCP, FRCP(E), Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; N. Milman, MD, MSc, FRCPC, Department of Rheumatology, University of Ottawa; J. Peck, RN, Faculty of Health and Applied Sciences, University of the West of England, Bristol and School of Clinical Sciences, University of Bristol; J.A. Shea, PhD, Division of General Internal Medicine, University of Pennsylvania; S. Carette, MD, Division of Rheumatology, Mount Sinai Hospital; N. Khalidi, MD, Division of Rheumatology, St. Joseph’s Healthcare, McMaster University; C.L. Koening, MD, Division of Rheumatology, University of Utah; C.A. Langford, MD, Department of Rheumatology, Cleveland Clinic; P.A. Monach, MD, PhD, Section of Rheumatology, Boston University School of Medicine; L. Moreland, MD, Division of Rheumatology, University of Pittsburgh; C. Pagnoux, MD, MSc, MPH, Division of Rheumatology, Mount Sinai Hospital; U. Specks, MD, Division of Pulmonology and Critical Care Medicine, Mayo Clinic College of Medicine and Science; A.G. Sreih, MD, Division of Rheumatology, University of Pennsylvania; S.R. Ytterberg, MD, Division of Rheumatology, Mayo Clinic College of Medicine and Science; P.A. Merkel, MD, MPH, Division of Rheumatology, University of Pennsylvania. Address correspondence to Dr. G. Tomasson, Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland, Sturlugata 8, 101 Reykjavik, Iceland. E-mail: gunnar.tomasson@gmail.com. Accepted for publication November 26, 2018.
Larry Moreland
From the Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland; Department of Rheumatology, and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; Department of Biostatistics, Epidemiology, and Informatics, and Division of Rheumatology, and Department of Family Medicine and Community Health, and Division of General Internal Medicine, University of Pennsylvania, Philadelphia; Division of Rheumatology, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Biostatistics and Informatics, Department of Pediatrics, University of South Florida, Tampa, Florida; Division of Rheumatology, University of Utah, Salt Lake City, Utah; Department of Rheumatology, Cleveland Clinic, Cleveland; Ohio State University Wexner Medical Center, Columbus, Ohio; Section of Rheumatology, Boston University School of Medicine, Boston, Massachusetts; Division of Rheumatology, and Division of Pulmonology and Critical Care Medicine, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA; Nuffield Department of Population Health, Health Services Research Unit (HSRU), and Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford; Faculty of Health and Applied Sciences, University of the West of England, Bristol and School of Clinical Sciences, University of Bristol, Bristol, UK; Department of Rheumatology, University of Ottawa, Ottawa; Division of Rheumatology, Mount Sinai Hospital, Toronto; Division of Rheumatology, St. Joseph’s Healthcare, McMaster University, Hamilton, Ontario, Canada. This work was supported by The Vasculitis Clinical Research Consortium (VCRC; U54 AR057319 and R01 AR 064153), which is part of the Rare Diseases Clinical Research Network, an initiative of the US Office of Rare Diseases Research, National Center for Advancing Translational Science (NCATS). The VCRC is funded through collaboration between NCATS, and the National Institute of Arthritis and Musculoskeletal and Skin Diseases, and has received funding from the National Center for Research Resources (U54 RR019497). Additional support for this work was provided by a contract from the Patient-Centered Outcomes Research Institute (IP2PI000603). G. Tomasson, MD, PhD, Assistant Professor, Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland, and Department of Rheumatology, and Centre for Rheumatology Research, University Hospital; J.T. Farrar, MD, Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania; D. Cuthbertson, MS, Department of Biostatistics and Informatics, Department of Pediatrics, University of South Florida; C.A. McAlear, MA, Division of Rheumatology, University of Pennsylvania; S. Ashdown, RN, Oxfordshire; P.F. Cronholm, MD, MSCE, Department of Family Medicine and Community Health, University of Pennsylvania; J. Dawson, MA, MSc, DPhil, SRN, SCM, Nuffield Department of Population Health (HSRU), University of Oxford; D. Gebhart, MD, Ohio State University Wexner Medical Center, Columbus; G. Lanier, Patient Research Partner, Boston; R.A. Luqmani, DM, FRCP, FRCP(E), Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; N. Milman, MD, MSc, FRCPC, Department of Rheumatology, University of Ottawa; J. Peck, RN, Faculty of Health and Applied Sciences, University of the West of England, Bristol and School of Clinical Sciences, University of Bristol; J.A. Shea, PhD, Division of General Internal Medicine, University of Pennsylvania; S. Carette, MD, Division of Rheumatology, Mount Sinai Hospital; N. Khalidi, MD, Division of Rheumatology, St. Joseph’s Healthcare, McMaster University; C.L. Koening, MD, Division of Rheumatology, University of Utah; C.A. Langford, MD, Department of Rheumatology, Cleveland Clinic; P.A. Monach, MD, PhD, Section of Rheumatology, Boston University School of Medicine; L. Moreland, MD, Division of Rheumatology, University of Pittsburgh; C. Pagnoux, MD, MSc, MPH, Division of Rheumatology, Mount Sinai Hospital; U. Specks, MD, Division of Pulmonology and Critical Care Medicine, Mayo Clinic College of Medicine and Science; A.G. Sreih, MD, Division of Rheumatology, University of Pennsylvania; S.R. Ytterberg, MD, Division of Rheumatology, Mayo Clinic College of Medicine and Science; P.A. Merkel, MD, MPH, Division of Rheumatology, University of Pennsylvania. Address correspondence to Dr. G. Tomasson, Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland, Sturlugata 8, 101 Reykjavik, Iceland. E-mail: gunnar.tomasson@gmail.com. Accepted for publication November 26, 2018.
Christian Pagnoux
From the Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland; Department of Rheumatology, and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; Department of Biostatistics, Epidemiology, and Informatics, and Division of Rheumatology, and Department of Family Medicine and Community Health, and Division of General Internal Medicine, University of Pennsylvania, Philadelphia; Division of Rheumatology, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Biostatistics and Informatics, Department of Pediatrics, University of South Florida, Tampa, Florida; Division of Rheumatology, University of Utah, Salt Lake City, Utah; Department of Rheumatology, Cleveland Clinic, Cleveland; Ohio State University Wexner Medical Center, Columbus, Ohio; Section of Rheumatology, Boston University School of Medicine, Boston, Massachusetts; Division of Rheumatology, and Division of Pulmonology and Critical Care Medicine, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA; Nuffield Department of Population Health, Health Services Research Unit (HSRU), and Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford; Faculty of Health and Applied Sciences, University of the West of England, Bristol and School of Clinical Sciences, University of Bristol, Bristol, UK; Department of Rheumatology, University of Ottawa, Ottawa; Division of Rheumatology, Mount Sinai Hospital, Toronto; Division of Rheumatology, St. Joseph’s Healthcare, McMaster University, Hamilton, Ontario, Canada. This work was supported by The Vasculitis Clinical Research Consortium (VCRC; U54 AR057319 and R01 AR 064153), which is part of the Rare Diseases Clinical Research Network, an initiative of the US Office of Rare Diseases Research, National Center for Advancing Translational Science (NCATS). The VCRC is funded through collaboration between NCATS, and the National Institute of Arthritis and Musculoskeletal and Skin Diseases, and has received funding from the National Center for Research Resources (U54 RR019497). Additional support for this work was provided by a contract from the Patient-Centered Outcomes Research Institute (IP2PI000603). G. Tomasson, MD, PhD, Assistant Professor, Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland, and Department of Rheumatology, and Centre for Rheumatology Research, University Hospital; J.T. Farrar, MD, Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania; D. Cuthbertson, MS, Department of Biostatistics and Informatics, Department of Pediatrics, University of South Florida; C.A. McAlear, MA, Division of Rheumatology, University of Pennsylvania; S. Ashdown, RN, Oxfordshire; P.F. Cronholm, MD, MSCE, Department of Family Medicine and Community Health, University of Pennsylvania; J. Dawson, MA, MSc, DPhil, SRN, SCM, Nuffield Department of Population Health (HSRU), University of Oxford; D. Gebhart, MD, Ohio State University Wexner Medical Center, Columbus; G. Lanier, Patient Research Partner, Boston; R.A. Luqmani, DM, FRCP, FRCP(E), Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; N. Milman, MD, MSc, FRCPC, Department of Rheumatology, University of Ottawa; J. Peck, RN, Faculty of Health and Applied Sciences, University of the West of England, Bristol and School of Clinical Sciences, University of Bristol; J.A. Shea, PhD, Division of General Internal Medicine, University of Pennsylvania; S. Carette, MD, Division of Rheumatology, Mount Sinai Hospital; N. Khalidi, MD, Division of Rheumatology, St. Joseph’s Healthcare, McMaster University; C.L. Koening, MD, Division of Rheumatology, University of Utah; C.A. Langford, MD, Department of Rheumatology, Cleveland Clinic; P.A. Monach, MD, PhD, Section of Rheumatology, Boston University School of Medicine; L. Moreland, MD, Division of Rheumatology, University of Pittsburgh; C. Pagnoux, MD, MSc, MPH, Division of Rheumatology, Mount Sinai Hospital; U. Specks, MD, Division of Pulmonology and Critical Care Medicine, Mayo Clinic College of Medicine and Science; A.G. Sreih, MD, Division of Rheumatology, University of Pennsylvania; S.R. Ytterberg, MD, Division of Rheumatology, Mayo Clinic College of Medicine and Science; P.A. Merkel, MD, MPH, Division of Rheumatology, University of Pennsylvania. Address correspondence to Dr. G. Tomasson, Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland, Sturlugata 8, 101 Reykjavik, Iceland. E-mail: gunnar.tomasson@gmail.com. Accepted for publication November 26, 2018.
Ulrich Specks
From the Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland; Department of Rheumatology, and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; Department of Biostatistics, Epidemiology, and Informatics, and Division of Rheumatology, and Department of Family Medicine and Community Health, and Division of General Internal Medicine, University of Pennsylvania, Philadelphia; Division of Rheumatology, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Biostatistics and Informatics, Department of Pediatrics, University of South Florida, Tampa, Florida; Division of Rheumatology, University of Utah, Salt Lake City, Utah; Department of Rheumatology, Cleveland Clinic, Cleveland; Ohio State University Wexner Medical Center, Columbus, Ohio; Section of Rheumatology, Boston University School of Medicine, Boston, Massachusetts; Division of Rheumatology, and Division of Pulmonology and Critical Care Medicine, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA; Nuffield Department of Population Health, Health Services Research Unit (HSRU), and Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford; Faculty of Health and Applied Sciences, University of the West of England, Bristol and School of Clinical Sciences, University of Bristol, Bristol, UK; Department of Rheumatology, University of Ottawa, Ottawa; Division of Rheumatology, Mount Sinai Hospital, Toronto; Division of Rheumatology, St. Joseph’s Healthcare, McMaster University, Hamilton, Ontario, Canada. This work was supported by The Vasculitis Clinical Research Consortium (VCRC; U54 AR057319 and R01 AR 064153), which is part of the Rare Diseases Clinical Research Network, an initiative of the US Office of Rare Diseases Research, National Center for Advancing Translational Science (NCATS). The VCRC is funded through collaboration between NCATS, and the National Institute of Arthritis and Musculoskeletal and Skin Diseases, and has received funding from the National Center for Research Resources (U54 RR019497). Additional support for this work was provided by a contract from the Patient-Centered Outcomes Research Institute (IP2PI000603). G. Tomasson, MD, PhD, Assistant Professor, Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland, and Department of Rheumatology, and Centre for Rheumatology Research, University Hospital; J.T. Farrar, MD, Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania; D. Cuthbertson, MS, Department of Biostatistics and Informatics, Department of Pediatrics, University of South Florida; C.A. McAlear, MA, Division of Rheumatology, University of Pennsylvania; S. Ashdown, RN, Oxfordshire; P.F. Cronholm, MD, MSCE, Department of Family Medicine and Community Health, University of Pennsylvania; J. Dawson, MA, MSc, DPhil, SRN, SCM, Nuffield Department of Population Health (HSRU), University of Oxford; D. Gebhart, MD, Ohio State University Wexner Medical Center, Columbus; G. Lanier, Patient Research Partner, Boston; R.A. Luqmani, DM, FRCP, FRCP(E), Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; N. Milman, MD, MSc, FRCPC, Department of Rheumatology, University of Ottawa; J. Peck, RN, Faculty of Health and Applied Sciences, University of the West of England, Bristol and School of Clinical Sciences, University of Bristol; J.A. Shea, PhD, Division of General Internal Medicine, University of Pennsylvania; S. Carette, MD, Division of Rheumatology, Mount Sinai Hospital; N. Khalidi, MD, Division of Rheumatology, St. Joseph’s Healthcare, McMaster University; C.L. Koening, MD, Division of Rheumatology, University of Utah; C.A. Langford, MD, Department of Rheumatology, Cleveland Clinic; P.A. Monach, MD, PhD, Section of Rheumatology, Boston University School of Medicine; L. Moreland, MD, Division of Rheumatology, University of Pittsburgh; C. Pagnoux, MD, MSc, MPH, Division of Rheumatology, Mount Sinai Hospital; U. Specks, MD, Division of Pulmonology and Critical Care Medicine, Mayo Clinic College of Medicine and Science; A.G. Sreih, MD, Division of Rheumatology, University of Pennsylvania; S.R. Ytterberg, MD, Division of Rheumatology, Mayo Clinic College of Medicine and Science; P.A. Merkel, MD, MPH, Division of Rheumatology, University of Pennsylvania. Address correspondence to Dr. G. Tomasson, Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland, Sturlugata 8, 101 Reykjavik, Iceland. E-mail: gunnar.tomasson@gmail.com. Accepted for publication November 26, 2018.
Antoine G. Sreih
From the Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland; Department of Rheumatology, and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; Department of Biostatistics, Epidemiology, and Informatics, and Division of Rheumatology, and Department of Family Medicine and Community Health, and Division of General Internal Medicine, University of Pennsylvania, Philadelphia; Division of Rheumatology, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Biostatistics and Informatics, Department of Pediatrics, University of South Florida, Tampa, Florida; Division of Rheumatology, University of Utah, Salt Lake City, Utah; Department of Rheumatology, Cleveland Clinic, Cleveland; Ohio State University Wexner Medical Center, Columbus, Ohio; Section of Rheumatology, Boston University School of Medicine, Boston, Massachusetts; Division of Rheumatology, and Division of Pulmonology and Critical Care Medicine, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA; Nuffield Department of Population Health, Health Services Research Unit (HSRU), and Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford; Faculty of Health and Applied Sciences, University of the West of England, Bristol and School of Clinical Sciences, University of Bristol, Bristol, UK; Department of Rheumatology, University of Ottawa, Ottawa; Division of Rheumatology, Mount Sinai Hospital, Toronto; Division of Rheumatology, St. Joseph’s Healthcare, McMaster University, Hamilton, Ontario, Canada. This work was supported by The Vasculitis Clinical Research Consortium (VCRC; U54 AR057319 and R01 AR 064153), which is part of the Rare Diseases Clinical Research Network, an initiative of the US Office of Rare Diseases Research, National Center for Advancing Translational Science (NCATS). The VCRC is funded through collaboration between NCATS, and the National Institute of Arthritis and Musculoskeletal and Skin Diseases, and has received funding from the National Center for Research Resources (U54 RR019497). Additional support for this work was provided by a contract from the Patient-Centered Outcomes Research Institute (IP2PI000603). G. Tomasson, MD, PhD, Assistant Professor, Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland, and Department of Rheumatology, and Centre for Rheumatology Research, University Hospital; J.T. Farrar, MD, Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania; D. Cuthbertson, MS, Department of Biostatistics and Informatics, Department of Pediatrics, University of South Florida; C.A. McAlear, MA, Division of Rheumatology, University of Pennsylvania; S. Ashdown, RN, Oxfordshire; P.F. Cronholm, MD, MSCE, Department of Family Medicine and Community Health, University of Pennsylvania; J. Dawson, MA, MSc, DPhil, SRN, SCM, Nuffield Department of Population Health (HSRU), University of Oxford; D. Gebhart, MD, Ohio State University Wexner Medical Center, Columbus; G. Lanier, Patient Research Partner, Boston; R.A. Luqmani, DM, FRCP, FRCP(E), Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; N. Milman, MD, MSc, FRCPC, Department of Rheumatology, University of Ottawa; J. Peck, RN, Faculty of Health and Applied Sciences, University of the West of England, Bristol and School of Clinical Sciences, University of Bristol; J.A. Shea, PhD, Division of General Internal Medicine, University of Pennsylvania; S. Carette, MD, Division of Rheumatology, Mount Sinai Hospital; N. Khalidi, MD, Division of Rheumatology, St. Joseph’s Healthcare, McMaster University; C.L. Koening, MD, Division of Rheumatology, University of Utah; C.A. Langford, MD, Department of Rheumatology, Cleveland Clinic; P.A. Monach, MD, PhD, Section of Rheumatology, Boston University School of Medicine; L. Moreland, MD, Division of Rheumatology, University of Pittsburgh; C. Pagnoux, MD, MSc, MPH, Division of Rheumatology, Mount Sinai Hospital; U. Specks, MD, Division of Pulmonology and Critical Care Medicine, Mayo Clinic College of Medicine and Science; A.G. Sreih, MD, Division of Rheumatology, University of Pennsylvania; S.R. Ytterberg, MD, Division of Rheumatology, Mayo Clinic College of Medicine and Science; P.A. Merkel, MD, MPH, Division of Rheumatology, University of Pennsylvania. Address correspondence to Dr. G. Tomasson, Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland, Sturlugata 8, 101 Reykjavik, Iceland. E-mail: gunnar.tomasson@gmail.com. Accepted for publication November 26, 2018.
Steven R. Ytterberg
From the Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland; Department of Rheumatology, and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; Department of Biostatistics, Epidemiology, and Informatics, and Division of Rheumatology, and Department of Family Medicine and Community Health, and Division of General Internal Medicine, University of Pennsylvania, Philadelphia; Division of Rheumatology, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Biostatistics and Informatics, Department of Pediatrics, University of South Florida, Tampa, Florida; Division of Rheumatology, University of Utah, Salt Lake City, Utah; Department of Rheumatology, Cleveland Clinic, Cleveland; Ohio State University Wexner Medical Center, Columbus, Ohio; Section of Rheumatology, Boston University School of Medicine, Boston, Massachusetts; Division of Rheumatology, and Division of Pulmonology and Critical Care Medicine, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA; Nuffield Department of Population Health, Health Services Research Unit (HSRU), and Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford; Faculty of Health and Applied Sciences, University of the West of England, Bristol and School of Clinical Sciences, University of Bristol, Bristol, UK; Department of Rheumatology, University of Ottawa, Ottawa; Division of Rheumatology, Mount Sinai Hospital, Toronto; Division of Rheumatology, St. Joseph’s Healthcare, McMaster University, Hamilton, Ontario, Canada. This work was supported by The Vasculitis Clinical Research Consortium (VCRC; U54 AR057319 and R01 AR 064153), which is part of the Rare Diseases Clinical Research Network, an initiative of the US Office of Rare Diseases Research, National Center for Advancing Translational Science (NCATS). The VCRC is funded through collaboration between NCATS, and the National Institute of Arthritis and Musculoskeletal and Skin Diseases, and has received funding from the National Center for Research Resources (U54 RR019497). Additional support for this work was provided by a contract from the Patient-Centered Outcomes Research Institute (IP2PI000603). G. Tomasson, MD, PhD, Assistant Professor, Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland, and Department of Rheumatology, and Centre for Rheumatology Research, University Hospital; J.T. Farrar, MD, Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania; D. Cuthbertson, MS, Department of Biostatistics and Informatics, Department of Pediatrics, University of South Florida; C.A. McAlear, MA, Division of Rheumatology, University of Pennsylvania; S. Ashdown, RN, Oxfordshire; P.F. Cronholm, MD, MSCE, Department of Family Medicine and Community Health, University of Pennsylvania; J. Dawson, MA, MSc, DPhil, SRN, SCM, Nuffield Department of Population Health (HSRU), University of Oxford; D. Gebhart, MD, Ohio State University Wexner Medical Center, Columbus; G. Lanier, Patient Research Partner, Boston; R.A. Luqmani, DM, FRCP, FRCP(E), Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; N. Milman, MD, MSc, FRCPC, Department of Rheumatology, University of Ottawa; J. Peck, RN, Faculty of Health and Applied Sciences, University of the West of England, Bristol and School of Clinical Sciences, University of Bristol; J.A. Shea, PhD, Division of General Internal Medicine, University of Pennsylvania; S. Carette, MD, Division of Rheumatology, Mount Sinai Hospital; N. Khalidi, MD, Division of Rheumatology, St. Joseph’s Healthcare, McMaster University; C.L. Koening, MD, Division of Rheumatology, University of Utah; C.A. Langford, MD, Department of Rheumatology, Cleveland Clinic; P.A. Monach, MD, PhD, Section of Rheumatology, Boston University School of Medicine; L. Moreland, MD, Division of Rheumatology, University of Pittsburgh; C. Pagnoux, MD, MSc, MPH, Division of Rheumatology, Mount Sinai Hospital; U. Specks, MD, Division of Pulmonology and Critical Care Medicine, Mayo Clinic College of Medicine and Science; A.G. Sreih, MD, Division of Rheumatology, University of Pennsylvania; S.R. Ytterberg, MD, Division of Rheumatology, Mayo Clinic College of Medicine and Science; P.A. Merkel, MD, MPH, Division of Rheumatology, University of Pennsylvania. Address correspondence to Dr. G. Tomasson, Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland, Sturlugata 8, 101 Reykjavik, Iceland. E-mail: gunnar.tomasson@gmail.com. Accepted for publication November 26, 2018.
Peter A. Merkel
From the Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland; Department of Rheumatology, and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; Department of Biostatistics, Epidemiology, and Informatics, and Division of Rheumatology, and Department of Family Medicine and Community Health, and Division of General Internal Medicine, University of Pennsylvania, Philadelphia; Division of Rheumatology, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Biostatistics and Informatics, Department of Pediatrics, University of South Florida, Tampa, Florida; Division of Rheumatology, University of Utah, Salt Lake City, Utah; Department of Rheumatology, Cleveland Clinic, Cleveland; Ohio State University Wexner Medical Center, Columbus, Ohio; Section of Rheumatology, Boston University School of Medicine, Boston, Massachusetts; Division of Rheumatology, and Division of Pulmonology and Critical Care Medicine, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA; Nuffield Department of Population Health, Health Services Research Unit (HSRU), and Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford; Faculty of Health and Applied Sciences, University of the West of England, Bristol and School of Clinical Sciences, University of Bristol, Bristol, UK; Department of Rheumatology, University of Ottawa, Ottawa; Division of Rheumatology, Mount Sinai Hospital, Toronto; Division of Rheumatology, St. Joseph’s Healthcare, McMaster University, Hamilton, Ontario, Canada. This work was supported by The Vasculitis Clinical Research Consortium (VCRC; U54 AR057319 and R01 AR 064153), which is part of the Rare Diseases Clinical Research Network, an initiative of the US Office of Rare Diseases Research, National Center for Advancing Translational Science (NCATS). The VCRC is funded through collaboration between NCATS, and the National Institute of Arthritis and Musculoskeletal and Skin Diseases, and has received funding from the National Center for Research Resources (U54 RR019497). Additional support for this work was provided by a contract from the Patient-Centered Outcomes Research Institute (IP2PI000603). G. Tomasson, MD, PhD, Assistant Professor, Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland, and Department of Rheumatology, and Centre for Rheumatology Research, University Hospital; J.T. Farrar, MD, Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania; D. Cuthbertson, MS, Department of Biostatistics and Informatics, Department of Pediatrics, University of South Florida; C.A. McAlear, MA, Division of Rheumatology, University of Pennsylvania; S. Ashdown, RN, Oxfordshire; P.F. Cronholm, MD, MSCE, Department of Family Medicine and Community Health, University of Pennsylvania; J. Dawson, MA, MSc, DPhil, SRN, SCM, Nuffield Department of Population Health (HSRU), University of Oxford; D. Gebhart, MD, Ohio State University Wexner Medical Center, Columbus; G. Lanier, Patient Research Partner, Boston; R.A. Luqmani, DM, FRCP, FRCP(E), Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; N. Milman, MD, MSc, FRCPC, Department of Rheumatology, University of Ottawa; J. Peck, RN, Faculty of Health and Applied Sciences, University of the West of England, Bristol and School of Clinical Sciences, University of Bristol; J.A. Shea, PhD, Division of General Internal Medicine, University of Pennsylvania; S. Carette, MD, Division of Rheumatology, Mount Sinai Hospital; N. Khalidi, MD, Division of Rheumatology, St. Joseph’s Healthcare, McMaster University; C.L. Koening, MD, Division of Rheumatology, University of Utah; C.A. Langford, MD, Department of Rheumatology, Cleveland Clinic; P.A. Monach, MD, PhD, Section of Rheumatology, Boston University School of Medicine; L. Moreland, MD, Division of Rheumatology, University of Pittsburgh; C. Pagnoux, MD, MSc, MPH, Division of Rheumatology, Mount Sinai Hospital; U. Specks, MD, Division of Pulmonology and Critical Care Medicine, Mayo Clinic College of Medicine and Science; A.G. Sreih, MD, Division of Rheumatology, University of Pennsylvania; S.R. Ytterberg, MD, Division of Rheumatology, Mayo Clinic College of Medicine and Science; P.A. Merkel, MD, MPH, Division of Rheumatology, University of Pennsylvania. Address correspondence to Dr. G. Tomasson, Department of Epidemiology and Biostatistics, Faculty of Medicine, University of Iceland, Sturlugata 8, 101 Reykjavik, Iceland. E-mail: gunnar.tomasson@gmail.com. Accepted for publication November 26, 2018.
Published eLetters
eLetters are comments published online only and are not peer-reviewed. Publication of eLetter submissions is not guaranteed, and all submissions are reviewed and edited at the discretion of The Journal's staff.
If you wish to publish Letters to the Editor or Correspondence, please submit through our online submission system ScholarOne Manuscripts.
Jump to comment:
No eLetters have been published for this article.
In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Feasibility and Construct Validation of the Patient Reported Outcomes Measurement Information System in Systemic Vasculitis
Gunnar Tomasson, John T. Farrar, David Cuthbertson, Carol A. McAlear, Susan Ashdown, Peter F. Cronholm, Jill Dawson, Don Gebhart, Georgia Lanier, Raashid A. Luqmani, Nataliya Milman, Jacqueline Peck, Joanna C. Robson, Judy A. Shea, Simon Carette, Nader Khalidi, Curry L. Koening, Carol A. Langford, Paul A. Monach, Larry Moreland, Christian Pagnoux, Ulrich Specks, Antoine G. Sreih, Steven R. Ytterberg, Peter A. Merkel
The Journal of Rheumatology Mar 2019, jrheum.171405; DOI: 10.3899/jrheum.171405
Feasibility and Construct Validation of the Patient Reported Outcomes Measurement Information System in Systemic Vasculitis
Gunnar Tomasson, John T. Farrar, David Cuthbertson, Carol A. McAlear, Susan Ashdown, Peter F. Cronholm, Jill Dawson, Don Gebhart, Georgia Lanier, Raashid A. Luqmani, Nataliya Milman, Jacqueline Peck, Joanna C. Robson, Judy A. Shea, Simon Carette, Nader Khalidi, Curry L. Koening, Carol A. Langford, Paul A. Monach, Larry Moreland, Christian Pagnoux, Ulrich Specks, Antoine G. Sreih, Steven R. Ytterberg, Peter A. Merkel
The Journal of Rheumatology Mar 2019, jrheum.171405; DOI: 10.3899/jrheum.171405