Research ArticleArticle
Pain Measurement in Rheumatic and Musculoskeletal Diseases: Where To Go from Here? Report from a Special Interest Group at OMERACT 2018
Alessandro Chiarotto, Ulrike Kaiser, Ernest Choy, Robin Christensen, Philip G. Conaghan, Mary Cowern, Michael Gill, Maarten de Wit, Elizabeth Gargon, Ben Horgan, Jamie J. Kirkham, Lee S. Simon, Jasvinder A. Singh, Peter Tugwell, Dennis C. Turk and Philip J. Mease
The Journal of Rheumatology April 2019, jrheum.181099; DOI: https://doi.org/10.3899/jrheum.181099
Alessandro Chiarotto
From the Department of Epidemiology and Biostatistics, Amsterdam University Medical Centre (VUmc); VUmc, Department of Medical Humanities, Amsterdam Public Health (APH), Amsterdam; Department of General Practice, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands; Comprehensive Pain Center, University Hospital Carl Gustav Carus Dresden, Medical Faculty of the Technical University Dresden, Dresden, Germany; CREATE Centre, Section of Rheumatology, Division of Infection and Immunity, Cardiff University, Cardiff; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; UK National Institute for Health Research (NIHR) Leeds Biomedical Research Centre, Leeds; Versus Arthritis, Patron Her Royal Highness The Duchess of Cornwall, Chesterfield; MRC North West Hub for Trials Methodology Research, Department of Biostatistics, University of Liverpool, Liverpool, UK; Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen; The Rheumatology Research Unit, Department of Rheumatology, Odense University Hospital; Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark; Dragon Claw (Website for patients with rheumatic disease), New South Wales, Australia; Bingo and Fundraising Promotions, Mal Atwell Leisure Group, Willetton, Australia; SDG LLC, Cambridge, Massachusetts; Medicine Service, VA Medical Center; Departments of Medicine and Epidemiology at the Schools of Medicine and Public Health, University of Alabama at Birmingham, Birmingham, Alabama; Department of Anesthesiology and Pain Medicine, University of Washington; Rheumatology Research Swedish-Providence-St. Joseph Health Systems; University of Washington School of Medicine, Seattle, Washington, USA; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada. AC is supported by a postdoctoral fellowship of the Amsterdam Movement Sciences research institute; he was supported by OMERACT and by a European League Against Rheumatism bursary to attend the OMERACT 2018 conference. UK is funded by a postdoctoral fellowship of the Medical Faculty, Technical University Dresden, and also funded by a federal joint committee of Germany. EC is supported in part by Arthritis Research UK and Health and Care Research Wales through the CREATE Centre. The Parker Institute, Bispebjerg and Frederiksberg Hospital is supported by a core grant from the Oak Foundation (OCAY-13-309). PGC is supported in part by the NIHR Leeds Biomedical Research Centre. The views expressed are those of the author(s) and not necessarily those of the UK National Health Service, the NIHR, or the Department of Health. DCT is supported by the US National Institutes of Health (NIH) and the US Food and Drug Administration. EC has received research grants and/or served as member of advisory boards and speaker bureaus of AbbVie, Allergan, Amgen, AstraZeneca, Bio-Cancer, Biogen, BMS, Boehringer Ingelheim, Celgene, Chugai Pharma, Daiichi Sankyo, Eli Lilly, Ferring Pharmaceutical, GSK, Hospira, ISIS, Jazz Pharmaceuticals, Janssen, MedImmune, Merrimack Pharmaceutical, MSD, Napp, Novimmune, Novartis, ObsEva, Pfizer, Regeneron, Roche, R-Pharm, Sanofi, SynAct Pharma, Synovate, Tonix, and UCB. JAS has received consultant fees from Crealta/Horizon, Fidia, UBM LLC, Medscape, WebMD, the NIH, and the American College of Rheumatology. JAS is a member of the Veterans Affairs Rheumatology Field Advisory Committee. JAS is the editor and the Director of the UAB Cochrane Musculoskeletal Group Satellite Center on Network Meta-analysis. JAS served as a member of the American College of Rheumatology’s (ACR) Annual Meeting Planning Committee and Quality of Care Committees, the Chair of the ACR Meet-the-Professor, Workshop and Study Group Subcommittee and the co-chair of the ACR Criteria and Response Criteria subcommittee. JAS is a member of the executive of OMERACT, an organization that develops outcome measures in rheumatology and receives arms-length funding from 36 companies. DCT is the editor-in-chief of The Clinical Journal of Pain and serves as an industry advisor or consultant to AcelRx, GSK/Novartis, and Pfizer. A. Chiarotto, PhD, Postdoctoral Research Fellow, Department of Epidemiology and Biostatistics, VUmc, and Department of General Practice, Erasmus MC, University Medical Center Rotterdam; U. Kaiser, Dr. Rer. Nat., Postdoctoral Research Fellow and Principal Investigator, Comprehensive Pain Center, Medical Faculty of Technical University of Dresden; E. Choy, MD, Professor and Head of Rheumatology, Cardiff University; R. Christensen, PhD, Professor of Biostatistics and Clinical Epidemiology, The Rheumatology Research Unit, Department of Rheumatology, Odense University Hospital and University of Southern Denmark, and Head of Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital; P.G. Conaghan, MB BS, PhD, FRACP, FRCP, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Biomedical Research Centre; M. Cowern, OMERACT Patient Research Partner; M. Gill, BA, Australian National University, and Dragon Claw, and OMERACT Patient Research Partner; M. de Wit, PhD, OMERACT Patient Research Partner, and Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health; E. Gargon, PhD, Research Associate, Department of Biostatistics, University of Liverpool; B. Horgan, OMERACT Patient Research Partner; J.J. Kirkham, PhD, Senior Lecturer in Medical Statistics, Department of Biostatistics, University of Liverpool; L.S. Simon, MD, Principal, SDG LLC; J.A. Singh, MBBS, MPH, Endowed Professor of Medicine, University of Alabama at Birmingham; P. Tugwell, MD, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; D.C. Turk, PhD, John and Emma Bonica Endowed Chair and Professor of Anesthesiology and Pain Research, Department of Anesthesiology and Pain Medicine, University of Washington; P.J. Mease, MD, MACR, Director, Rheumatology Research, Swedish-Providence-St. Joseph Health Systems, and Clinical Professor, University of Washington School of Medicine. Address correspondence to Dr. A. Chiarotto, Department of Epidemiology and Biostatistics, Amsterdam Movement Sciences Research Institute, Amsterdam Public Health Research Institute, Amsterdam UMC (VU University Medical Center), Medical Faculty, F-vleugel, de Boelelaan 1089A, 1081HV Amsterdam, the Netherlands. E-mail: a.chiarotto@vu.nl. Accepted for publication March 8, 2019.
Ulrike Kaiser
From the Department of Epidemiology and Biostatistics, Amsterdam University Medical Centre (VUmc); VUmc, Department of Medical Humanities, Amsterdam Public Health (APH), Amsterdam; Department of General Practice, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands; Comprehensive Pain Center, University Hospital Carl Gustav Carus Dresden, Medical Faculty of the Technical University Dresden, Dresden, Germany; CREATE Centre, Section of Rheumatology, Division of Infection and Immunity, Cardiff University, Cardiff; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; UK National Institute for Health Research (NIHR) Leeds Biomedical Research Centre, Leeds; Versus Arthritis, Patron Her Royal Highness The Duchess of Cornwall, Chesterfield; MRC North West Hub for Trials Methodology Research, Department of Biostatistics, University of Liverpool, Liverpool, UK; Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen; The Rheumatology Research Unit, Department of Rheumatology, Odense University Hospital; Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark; Dragon Claw (Website for patients with rheumatic disease), New South Wales, Australia; Bingo and Fundraising Promotions, Mal Atwell Leisure Group, Willetton, Australia; SDG LLC, Cambridge, Massachusetts; Medicine Service, VA Medical Center; Departments of Medicine and Epidemiology at the Schools of Medicine and Public Health, University of Alabama at Birmingham, Birmingham, Alabama; Department of Anesthesiology and Pain Medicine, University of Washington; Rheumatology Research Swedish-Providence-St. Joseph Health Systems; University of Washington School of Medicine, Seattle, Washington, USA; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada. AC is supported by a postdoctoral fellowship of the Amsterdam Movement Sciences research institute; he was supported by OMERACT and by a European League Against Rheumatism bursary to attend the OMERACT 2018 conference. UK is funded by a postdoctoral fellowship of the Medical Faculty, Technical University Dresden, and also funded by a federal joint committee of Germany. EC is supported in part by Arthritis Research UK and Health and Care Research Wales through the CREATE Centre. The Parker Institute, Bispebjerg and Frederiksberg Hospital is supported by a core grant from the Oak Foundation (OCAY-13-309). PGC is supported in part by the NIHR Leeds Biomedical Research Centre. The views expressed are those of the author(s) and not necessarily those of the UK National Health Service, the NIHR, or the Department of Health. DCT is supported by the US National Institutes of Health (NIH) and the US Food and Drug Administration. EC has received research grants and/or served as member of advisory boards and speaker bureaus of AbbVie, Allergan, Amgen, AstraZeneca, Bio-Cancer, Biogen, BMS, Boehringer Ingelheim, Celgene, Chugai Pharma, Daiichi Sankyo, Eli Lilly, Ferring Pharmaceutical, GSK, Hospira, ISIS, Jazz Pharmaceuticals, Janssen, MedImmune, Merrimack Pharmaceutical, MSD, Napp, Novimmune, Novartis, ObsEva, Pfizer, Regeneron, Roche, R-Pharm, Sanofi, SynAct Pharma, Synovate, Tonix, and UCB. JAS has received consultant fees from Crealta/Horizon, Fidia, UBM LLC, Medscape, WebMD, the NIH, and the American College of Rheumatology. JAS is a member of the Veterans Affairs Rheumatology Field Advisory Committee. JAS is the editor and the Director of the UAB Cochrane Musculoskeletal Group Satellite Center on Network Meta-analysis. JAS served as a member of the American College of Rheumatology’s (ACR) Annual Meeting Planning Committee and Quality of Care Committees, the Chair of the ACR Meet-the-Professor, Workshop and Study Group Subcommittee and the co-chair of the ACR Criteria and Response Criteria subcommittee. JAS is a member of the executive of OMERACT, an organization that develops outcome measures in rheumatology and receives arms-length funding from 36 companies. DCT is the editor-in-chief of The Clinical Journal of Pain and serves as an industry advisor or consultant to AcelRx, GSK/Novartis, and Pfizer. A. Chiarotto, PhD, Postdoctoral Research Fellow, Department of Epidemiology and Biostatistics, VUmc, and Department of General Practice, Erasmus MC, University Medical Center Rotterdam; U. Kaiser, Dr. Rer. Nat., Postdoctoral Research Fellow and Principal Investigator, Comprehensive Pain Center, Medical Faculty of Technical University of Dresden; E. Choy, MD, Professor and Head of Rheumatology, Cardiff University; R. Christensen, PhD, Professor of Biostatistics and Clinical Epidemiology, The Rheumatology Research Unit, Department of Rheumatology, Odense University Hospital and University of Southern Denmark, and Head of Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital; P.G. Conaghan, MB BS, PhD, FRACP, FRCP, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Biomedical Research Centre; M. Cowern, OMERACT Patient Research Partner; M. Gill, BA, Australian National University, and Dragon Claw, and OMERACT Patient Research Partner; M. de Wit, PhD, OMERACT Patient Research Partner, and Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health; E. Gargon, PhD, Research Associate, Department of Biostatistics, University of Liverpool; B. Horgan, OMERACT Patient Research Partner; J.J. Kirkham, PhD, Senior Lecturer in Medical Statistics, Department of Biostatistics, University of Liverpool; L.S. Simon, MD, Principal, SDG LLC; J.A. Singh, MBBS, MPH, Endowed Professor of Medicine, University of Alabama at Birmingham; P. Tugwell, MD, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; D.C. Turk, PhD, John and Emma Bonica Endowed Chair and Professor of Anesthesiology and Pain Research, Department of Anesthesiology and Pain Medicine, University of Washington; P.J. Mease, MD, MACR, Director, Rheumatology Research, Swedish-Providence-St. Joseph Health Systems, and Clinical Professor, University of Washington School of Medicine. Address correspondence to Dr. A. Chiarotto, Department of Epidemiology and Biostatistics, Amsterdam Movement Sciences Research Institute, Amsterdam Public Health Research Institute, Amsterdam UMC (VU University Medical Center), Medical Faculty, F-vleugel, de Boelelaan 1089A, 1081HV Amsterdam, the Netherlands. E-mail: a.chiarotto@vu.nl. Accepted for publication March 8, 2019.
Ernest Choy
From the Department of Epidemiology and Biostatistics, Amsterdam University Medical Centre (VUmc); VUmc, Department of Medical Humanities, Amsterdam Public Health (APH), Amsterdam; Department of General Practice, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands; Comprehensive Pain Center, University Hospital Carl Gustav Carus Dresden, Medical Faculty of the Technical University Dresden, Dresden, Germany; CREATE Centre, Section of Rheumatology, Division of Infection and Immunity, Cardiff University, Cardiff; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; UK National Institute for Health Research (NIHR) Leeds Biomedical Research Centre, Leeds; Versus Arthritis, Patron Her Royal Highness The Duchess of Cornwall, Chesterfield; MRC North West Hub for Trials Methodology Research, Department of Biostatistics, University of Liverpool, Liverpool, UK; Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen; The Rheumatology Research Unit, Department of Rheumatology, Odense University Hospital; Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark; Dragon Claw (Website for patients with rheumatic disease), New South Wales, Australia; Bingo and Fundraising Promotions, Mal Atwell Leisure Group, Willetton, Australia; SDG LLC, Cambridge, Massachusetts; Medicine Service, VA Medical Center; Departments of Medicine and Epidemiology at the Schools of Medicine and Public Health, University of Alabama at Birmingham, Birmingham, Alabama; Department of Anesthesiology and Pain Medicine, University of Washington; Rheumatology Research Swedish-Providence-St. Joseph Health Systems; University of Washington School of Medicine, Seattle, Washington, USA; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada. AC is supported by a postdoctoral fellowship of the Amsterdam Movement Sciences research institute; he was supported by OMERACT and by a European League Against Rheumatism bursary to attend the OMERACT 2018 conference. UK is funded by a postdoctoral fellowship of the Medical Faculty, Technical University Dresden, and also funded by a federal joint committee of Germany. EC is supported in part by Arthritis Research UK and Health and Care Research Wales through the CREATE Centre. The Parker Institute, Bispebjerg and Frederiksberg Hospital is supported by a core grant from the Oak Foundation (OCAY-13-309). PGC is supported in part by the NIHR Leeds Biomedical Research Centre. The views expressed are those of the author(s) and not necessarily those of the UK National Health Service, the NIHR, or the Department of Health. DCT is supported by the US National Institutes of Health (NIH) and the US Food and Drug Administration. EC has received research grants and/or served as member of advisory boards and speaker bureaus of AbbVie, Allergan, Amgen, AstraZeneca, Bio-Cancer, Biogen, BMS, Boehringer Ingelheim, Celgene, Chugai Pharma, Daiichi Sankyo, Eli Lilly, Ferring Pharmaceutical, GSK, Hospira, ISIS, Jazz Pharmaceuticals, Janssen, MedImmune, Merrimack Pharmaceutical, MSD, Napp, Novimmune, Novartis, ObsEva, Pfizer, Regeneron, Roche, R-Pharm, Sanofi, SynAct Pharma, Synovate, Tonix, and UCB. JAS has received consultant fees from Crealta/Horizon, Fidia, UBM LLC, Medscape, WebMD, the NIH, and the American College of Rheumatology. JAS is a member of the Veterans Affairs Rheumatology Field Advisory Committee. JAS is the editor and the Director of the UAB Cochrane Musculoskeletal Group Satellite Center on Network Meta-analysis. JAS served as a member of the American College of Rheumatology’s (ACR) Annual Meeting Planning Committee and Quality of Care Committees, the Chair of the ACR Meet-the-Professor, Workshop and Study Group Subcommittee and the co-chair of the ACR Criteria and Response Criteria subcommittee. JAS is a member of the executive of OMERACT, an organization that develops outcome measures in rheumatology and receives arms-length funding from 36 companies. DCT is the editor-in-chief of The Clinical Journal of Pain and serves as an industry advisor or consultant to AcelRx, GSK/Novartis, and Pfizer. A. Chiarotto, PhD, Postdoctoral Research Fellow, Department of Epidemiology and Biostatistics, VUmc, and Department of General Practice, Erasmus MC, University Medical Center Rotterdam; U. Kaiser, Dr. Rer. Nat., Postdoctoral Research Fellow and Principal Investigator, Comprehensive Pain Center, Medical Faculty of Technical University of Dresden; E. Choy, MD, Professor and Head of Rheumatology, Cardiff University; R. Christensen, PhD, Professor of Biostatistics and Clinical Epidemiology, The Rheumatology Research Unit, Department of Rheumatology, Odense University Hospital and University of Southern Denmark, and Head of Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital; P.G. Conaghan, MB BS, PhD, FRACP, FRCP, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Biomedical Research Centre; M. Cowern, OMERACT Patient Research Partner; M. Gill, BA, Australian National University, and Dragon Claw, and OMERACT Patient Research Partner; M. de Wit, PhD, OMERACT Patient Research Partner, and Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health; E. Gargon, PhD, Research Associate, Department of Biostatistics, University of Liverpool; B. Horgan, OMERACT Patient Research Partner; J.J. Kirkham, PhD, Senior Lecturer in Medical Statistics, Department of Biostatistics, University of Liverpool; L.S. Simon, MD, Principal, SDG LLC; J.A. Singh, MBBS, MPH, Endowed Professor of Medicine, University of Alabama at Birmingham; P. Tugwell, MD, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; D.C. Turk, PhD, John and Emma Bonica Endowed Chair and Professor of Anesthesiology and Pain Research, Department of Anesthesiology and Pain Medicine, University of Washington; P.J. Mease, MD, MACR, Director, Rheumatology Research, Swedish-Providence-St. Joseph Health Systems, and Clinical Professor, University of Washington School of Medicine. Address correspondence to Dr. A. Chiarotto, Department of Epidemiology and Biostatistics, Amsterdam Movement Sciences Research Institute, Amsterdam Public Health Research Institute, Amsterdam UMC (VU University Medical Center), Medical Faculty, F-vleugel, de Boelelaan 1089A, 1081HV Amsterdam, the Netherlands. E-mail: a.chiarotto@vu.nl. Accepted for publication March 8, 2019.
Robin Christensen
From the Department of Epidemiology and Biostatistics, Amsterdam University Medical Centre (VUmc); VUmc, Department of Medical Humanities, Amsterdam Public Health (APH), Amsterdam; Department of General Practice, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands; Comprehensive Pain Center, University Hospital Carl Gustav Carus Dresden, Medical Faculty of the Technical University Dresden, Dresden, Germany; CREATE Centre, Section of Rheumatology, Division of Infection and Immunity, Cardiff University, Cardiff; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; UK National Institute for Health Research (NIHR) Leeds Biomedical Research Centre, Leeds; Versus Arthritis, Patron Her Royal Highness The Duchess of Cornwall, Chesterfield; MRC North West Hub for Trials Methodology Research, Department of Biostatistics, University of Liverpool, Liverpool, UK; Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen; The Rheumatology Research Unit, Department of Rheumatology, Odense University Hospital; Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark; Dragon Claw (Website for patients with rheumatic disease), New South Wales, Australia; Bingo and Fundraising Promotions, Mal Atwell Leisure Group, Willetton, Australia; SDG LLC, Cambridge, Massachusetts; Medicine Service, VA Medical Center; Departments of Medicine and Epidemiology at the Schools of Medicine and Public Health, University of Alabama at Birmingham, Birmingham, Alabama; Department of Anesthesiology and Pain Medicine, University of Washington; Rheumatology Research Swedish-Providence-St. Joseph Health Systems; University of Washington School of Medicine, Seattle, Washington, USA; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada. AC is supported by a postdoctoral fellowship of the Amsterdam Movement Sciences research institute; he was supported by OMERACT and by a European League Against Rheumatism bursary to attend the OMERACT 2018 conference. UK is funded by a postdoctoral fellowship of the Medical Faculty, Technical University Dresden, and also funded by a federal joint committee of Germany. EC is supported in part by Arthritis Research UK and Health and Care Research Wales through the CREATE Centre. The Parker Institute, Bispebjerg and Frederiksberg Hospital is supported by a core grant from the Oak Foundation (OCAY-13-309). PGC is supported in part by the NIHR Leeds Biomedical Research Centre. The views expressed are those of the author(s) and not necessarily those of the UK National Health Service, the NIHR, or the Department of Health. DCT is supported by the US National Institutes of Health (NIH) and the US Food and Drug Administration. EC has received research grants and/or served as member of advisory boards and speaker bureaus of AbbVie, Allergan, Amgen, AstraZeneca, Bio-Cancer, Biogen, BMS, Boehringer Ingelheim, Celgene, Chugai Pharma, Daiichi Sankyo, Eli Lilly, Ferring Pharmaceutical, GSK, Hospira, ISIS, Jazz Pharmaceuticals, Janssen, MedImmune, Merrimack Pharmaceutical, MSD, Napp, Novimmune, Novartis, ObsEva, Pfizer, Regeneron, Roche, R-Pharm, Sanofi, SynAct Pharma, Synovate, Tonix, and UCB. JAS has received consultant fees from Crealta/Horizon, Fidia, UBM LLC, Medscape, WebMD, the NIH, and the American College of Rheumatology. JAS is a member of the Veterans Affairs Rheumatology Field Advisory Committee. JAS is the editor and the Director of the UAB Cochrane Musculoskeletal Group Satellite Center on Network Meta-analysis. JAS served as a member of the American College of Rheumatology’s (ACR) Annual Meeting Planning Committee and Quality of Care Committees, the Chair of the ACR Meet-the-Professor, Workshop and Study Group Subcommittee and the co-chair of the ACR Criteria and Response Criteria subcommittee. JAS is a member of the executive of OMERACT, an organization that develops outcome measures in rheumatology and receives arms-length funding from 36 companies. DCT is the editor-in-chief of The Clinical Journal of Pain and serves as an industry advisor or consultant to AcelRx, GSK/Novartis, and Pfizer. A. Chiarotto, PhD, Postdoctoral Research Fellow, Department of Epidemiology and Biostatistics, VUmc, and Department of General Practice, Erasmus MC, University Medical Center Rotterdam; U. Kaiser, Dr. Rer. Nat., Postdoctoral Research Fellow and Principal Investigator, Comprehensive Pain Center, Medical Faculty of Technical University of Dresden; E. Choy, MD, Professor and Head of Rheumatology, Cardiff University; R. Christensen, PhD, Professor of Biostatistics and Clinical Epidemiology, The Rheumatology Research Unit, Department of Rheumatology, Odense University Hospital and University of Southern Denmark, and Head of Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital; P.G. Conaghan, MB BS, PhD, FRACP, FRCP, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Biomedical Research Centre; M. Cowern, OMERACT Patient Research Partner; M. Gill, BA, Australian National University, and Dragon Claw, and OMERACT Patient Research Partner; M. de Wit, PhD, OMERACT Patient Research Partner, and Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health; E. Gargon, PhD, Research Associate, Department of Biostatistics, University of Liverpool; B. Horgan, OMERACT Patient Research Partner; J.J. Kirkham, PhD, Senior Lecturer in Medical Statistics, Department of Biostatistics, University of Liverpool; L.S. Simon, MD, Principal, SDG LLC; J.A. Singh, MBBS, MPH, Endowed Professor of Medicine, University of Alabama at Birmingham; P. Tugwell, MD, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; D.C. Turk, PhD, John and Emma Bonica Endowed Chair and Professor of Anesthesiology and Pain Research, Department of Anesthesiology and Pain Medicine, University of Washington; P.J. Mease, MD, MACR, Director, Rheumatology Research, Swedish-Providence-St. Joseph Health Systems, and Clinical Professor, University of Washington School of Medicine. Address correspondence to Dr. A. Chiarotto, Department of Epidemiology and Biostatistics, Amsterdam Movement Sciences Research Institute, Amsterdam Public Health Research Institute, Amsterdam UMC (VU University Medical Center), Medical Faculty, F-vleugel, de Boelelaan 1089A, 1081HV Amsterdam, the Netherlands. E-mail: a.chiarotto@vu.nl. Accepted for publication March 8, 2019.
Philip G. Conaghan
From the Department of Epidemiology and Biostatistics, Amsterdam University Medical Centre (VUmc); VUmc, Department of Medical Humanities, Amsterdam Public Health (APH), Amsterdam; Department of General Practice, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands; Comprehensive Pain Center, University Hospital Carl Gustav Carus Dresden, Medical Faculty of the Technical University Dresden, Dresden, Germany; CREATE Centre, Section of Rheumatology, Division of Infection and Immunity, Cardiff University, Cardiff; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; UK National Institute for Health Research (NIHR) Leeds Biomedical Research Centre, Leeds; Versus Arthritis, Patron Her Royal Highness The Duchess of Cornwall, Chesterfield; MRC North West Hub for Trials Methodology Research, Department of Biostatistics, University of Liverpool, Liverpool, UK; Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen; The Rheumatology Research Unit, Department of Rheumatology, Odense University Hospital; Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark; Dragon Claw (Website for patients with rheumatic disease), New South Wales, Australia; Bingo and Fundraising Promotions, Mal Atwell Leisure Group, Willetton, Australia; SDG LLC, Cambridge, Massachusetts; Medicine Service, VA Medical Center; Departments of Medicine and Epidemiology at the Schools of Medicine and Public Health, University of Alabama at Birmingham, Birmingham, Alabama; Department of Anesthesiology and Pain Medicine, University of Washington; Rheumatology Research Swedish-Providence-St. Joseph Health Systems; University of Washington School of Medicine, Seattle, Washington, USA; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada. AC is supported by a postdoctoral fellowship of the Amsterdam Movement Sciences research institute; he was supported by OMERACT and by a European League Against Rheumatism bursary to attend the OMERACT 2018 conference. UK is funded by a postdoctoral fellowship of the Medical Faculty, Technical University Dresden, and also funded by a federal joint committee of Germany. EC is supported in part by Arthritis Research UK and Health and Care Research Wales through the CREATE Centre. The Parker Institute, Bispebjerg and Frederiksberg Hospital is supported by a core grant from the Oak Foundation (OCAY-13-309). PGC is supported in part by the NIHR Leeds Biomedical Research Centre. The views expressed are those of the author(s) and not necessarily those of the UK National Health Service, the NIHR, or the Department of Health. DCT is supported by the US National Institutes of Health (NIH) and the US Food and Drug Administration. EC has received research grants and/or served as member of advisory boards and speaker bureaus of AbbVie, Allergan, Amgen, AstraZeneca, Bio-Cancer, Biogen, BMS, Boehringer Ingelheim, Celgene, Chugai Pharma, Daiichi Sankyo, Eli Lilly, Ferring Pharmaceutical, GSK, Hospira, ISIS, Jazz Pharmaceuticals, Janssen, MedImmune, Merrimack Pharmaceutical, MSD, Napp, Novimmune, Novartis, ObsEva, Pfizer, Regeneron, Roche, R-Pharm, Sanofi, SynAct Pharma, Synovate, Tonix, and UCB. JAS has received consultant fees from Crealta/Horizon, Fidia, UBM LLC, Medscape, WebMD, the NIH, and the American College of Rheumatology. JAS is a member of the Veterans Affairs Rheumatology Field Advisory Committee. JAS is the editor and the Director of the UAB Cochrane Musculoskeletal Group Satellite Center on Network Meta-analysis. JAS served as a member of the American College of Rheumatology’s (ACR) Annual Meeting Planning Committee and Quality of Care Committees, the Chair of the ACR Meet-the-Professor, Workshop and Study Group Subcommittee and the co-chair of the ACR Criteria and Response Criteria subcommittee. JAS is a member of the executive of OMERACT, an organization that develops outcome measures in rheumatology and receives arms-length funding from 36 companies. DCT is the editor-in-chief of The Clinical Journal of Pain and serves as an industry advisor or consultant to AcelRx, GSK/Novartis, and Pfizer. A. Chiarotto, PhD, Postdoctoral Research Fellow, Department of Epidemiology and Biostatistics, VUmc, and Department of General Practice, Erasmus MC, University Medical Center Rotterdam; U. Kaiser, Dr. Rer. Nat., Postdoctoral Research Fellow and Principal Investigator, Comprehensive Pain Center, Medical Faculty of Technical University of Dresden; E. Choy, MD, Professor and Head of Rheumatology, Cardiff University; R. Christensen, PhD, Professor of Biostatistics and Clinical Epidemiology, The Rheumatology Research Unit, Department of Rheumatology, Odense University Hospital and University of Southern Denmark, and Head of Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital; P.G. Conaghan, MB BS, PhD, FRACP, FRCP, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Biomedical Research Centre; M. Cowern, OMERACT Patient Research Partner; M. Gill, BA, Australian National University, and Dragon Claw, and OMERACT Patient Research Partner; M. de Wit, PhD, OMERACT Patient Research Partner, and Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health; E. Gargon, PhD, Research Associate, Department of Biostatistics, University of Liverpool; B. Horgan, OMERACT Patient Research Partner; J.J. Kirkham, PhD, Senior Lecturer in Medical Statistics, Department of Biostatistics, University of Liverpool; L.S. Simon, MD, Principal, SDG LLC; J.A. Singh, MBBS, MPH, Endowed Professor of Medicine, University of Alabama at Birmingham; P. Tugwell, MD, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; D.C. Turk, PhD, John and Emma Bonica Endowed Chair and Professor of Anesthesiology and Pain Research, Department of Anesthesiology and Pain Medicine, University of Washington; P.J. Mease, MD, MACR, Director, Rheumatology Research, Swedish-Providence-St. Joseph Health Systems, and Clinical Professor, University of Washington School of Medicine. Address correspondence to Dr. A. Chiarotto, Department of Epidemiology and Biostatistics, Amsterdam Movement Sciences Research Institute, Amsterdam Public Health Research Institute, Amsterdam UMC (VU University Medical Center), Medical Faculty, F-vleugel, de Boelelaan 1089A, 1081HV Amsterdam, the Netherlands. E-mail: a.chiarotto@vu.nl. Accepted for publication March 8, 2019.
Mary Cowern
From the Department of Epidemiology and Biostatistics, Amsterdam University Medical Centre (VUmc); VUmc, Department of Medical Humanities, Amsterdam Public Health (APH), Amsterdam; Department of General Practice, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands; Comprehensive Pain Center, University Hospital Carl Gustav Carus Dresden, Medical Faculty of the Technical University Dresden, Dresden, Germany; CREATE Centre, Section of Rheumatology, Division of Infection and Immunity, Cardiff University, Cardiff; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; UK National Institute for Health Research (NIHR) Leeds Biomedical Research Centre, Leeds; Versus Arthritis, Patron Her Royal Highness The Duchess of Cornwall, Chesterfield; MRC North West Hub for Trials Methodology Research, Department of Biostatistics, University of Liverpool, Liverpool, UK; Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen; The Rheumatology Research Unit, Department of Rheumatology, Odense University Hospital; Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark; Dragon Claw (Website for patients with rheumatic disease), New South Wales, Australia; Bingo and Fundraising Promotions, Mal Atwell Leisure Group, Willetton, Australia; SDG LLC, Cambridge, Massachusetts; Medicine Service, VA Medical Center; Departments of Medicine and Epidemiology at the Schools of Medicine and Public Health, University of Alabama at Birmingham, Birmingham, Alabama; Department of Anesthesiology and Pain Medicine, University of Washington; Rheumatology Research Swedish-Providence-St. Joseph Health Systems; University of Washington School of Medicine, Seattle, Washington, USA; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada. AC is supported by a postdoctoral fellowship of the Amsterdam Movement Sciences research institute; he was supported by OMERACT and by a European League Against Rheumatism bursary to attend the OMERACT 2018 conference. UK is funded by a postdoctoral fellowship of the Medical Faculty, Technical University Dresden, and also funded by a federal joint committee of Germany. EC is supported in part by Arthritis Research UK and Health and Care Research Wales through the CREATE Centre. The Parker Institute, Bispebjerg and Frederiksberg Hospital is supported by a core grant from the Oak Foundation (OCAY-13-309). PGC is supported in part by the NIHR Leeds Biomedical Research Centre. The views expressed are those of the author(s) and not necessarily those of the UK National Health Service, the NIHR, or the Department of Health. DCT is supported by the US National Institutes of Health (NIH) and the US Food and Drug Administration. EC has received research grants and/or served as member of advisory boards and speaker bureaus of AbbVie, Allergan, Amgen, AstraZeneca, Bio-Cancer, Biogen, BMS, Boehringer Ingelheim, Celgene, Chugai Pharma, Daiichi Sankyo, Eli Lilly, Ferring Pharmaceutical, GSK, Hospira, ISIS, Jazz Pharmaceuticals, Janssen, MedImmune, Merrimack Pharmaceutical, MSD, Napp, Novimmune, Novartis, ObsEva, Pfizer, Regeneron, Roche, R-Pharm, Sanofi, SynAct Pharma, Synovate, Tonix, and UCB. JAS has received consultant fees from Crealta/Horizon, Fidia, UBM LLC, Medscape, WebMD, the NIH, and the American College of Rheumatology. JAS is a member of the Veterans Affairs Rheumatology Field Advisory Committee. JAS is the editor and the Director of the UAB Cochrane Musculoskeletal Group Satellite Center on Network Meta-analysis. JAS served as a member of the American College of Rheumatology’s (ACR) Annual Meeting Planning Committee and Quality of Care Committees, the Chair of the ACR Meet-the-Professor, Workshop and Study Group Subcommittee and the co-chair of the ACR Criteria and Response Criteria subcommittee. JAS is a member of the executive of OMERACT, an organization that develops outcome measures in rheumatology and receives arms-length funding from 36 companies. DCT is the editor-in-chief of The Clinical Journal of Pain and serves as an industry advisor or consultant to AcelRx, GSK/Novartis, and Pfizer. A. Chiarotto, PhD, Postdoctoral Research Fellow, Department of Epidemiology and Biostatistics, VUmc, and Department of General Practice, Erasmus MC, University Medical Center Rotterdam; U. Kaiser, Dr. Rer. Nat., Postdoctoral Research Fellow and Principal Investigator, Comprehensive Pain Center, Medical Faculty of Technical University of Dresden; E. Choy, MD, Professor and Head of Rheumatology, Cardiff University; R. Christensen, PhD, Professor of Biostatistics and Clinical Epidemiology, The Rheumatology Research Unit, Department of Rheumatology, Odense University Hospital and University of Southern Denmark, and Head of Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital; P.G. Conaghan, MB BS, PhD, FRACP, FRCP, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Biomedical Research Centre; M. Cowern, OMERACT Patient Research Partner; M. Gill, BA, Australian National University, and Dragon Claw, and OMERACT Patient Research Partner; M. de Wit, PhD, OMERACT Patient Research Partner, and Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health; E. Gargon, PhD, Research Associate, Department of Biostatistics, University of Liverpool; B. Horgan, OMERACT Patient Research Partner; J.J. Kirkham, PhD, Senior Lecturer in Medical Statistics, Department of Biostatistics, University of Liverpool; L.S. Simon, MD, Principal, SDG LLC; J.A. Singh, MBBS, MPH, Endowed Professor of Medicine, University of Alabama at Birmingham; P. Tugwell, MD, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; D.C. Turk, PhD, John and Emma Bonica Endowed Chair and Professor of Anesthesiology and Pain Research, Department of Anesthesiology and Pain Medicine, University of Washington; P.J. Mease, MD, MACR, Director, Rheumatology Research, Swedish-Providence-St. Joseph Health Systems, and Clinical Professor, University of Washington School of Medicine. Address correspondence to Dr. A. Chiarotto, Department of Epidemiology and Biostatistics, Amsterdam Movement Sciences Research Institute, Amsterdam Public Health Research Institute, Amsterdam UMC (VU University Medical Center), Medical Faculty, F-vleugel, de Boelelaan 1089A, 1081HV Amsterdam, the Netherlands. E-mail: a.chiarotto@vu.nl. Accepted for publication March 8, 2019.
Michael Gill
From the Department of Epidemiology and Biostatistics, Amsterdam University Medical Centre (VUmc); VUmc, Department of Medical Humanities, Amsterdam Public Health (APH), Amsterdam; Department of General Practice, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands; Comprehensive Pain Center, University Hospital Carl Gustav Carus Dresden, Medical Faculty of the Technical University Dresden, Dresden, Germany; CREATE Centre, Section of Rheumatology, Division of Infection and Immunity, Cardiff University, Cardiff; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; UK National Institute for Health Research (NIHR) Leeds Biomedical Research Centre, Leeds; Versus Arthritis, Patron Her Royal Highness The Duchess of Cornwall, Chesterfield; MRC North West Hub for Trials Methodology Research, Department of Biostatistics, University of Liverpool, Liverpool, UK; Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen; The Rheumatology Research Unit, Department of Rheumatology, Odense University Hospital; Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark; Dragon Claw (Website for patients with rheumatic disease), New South Wales, Australia; Bingo and Fundraising Promotions, Mal Atwell Leisure Group, Willetton, Australia; SDG LLC, Cambridge, Massachusetts; Medicine Service, VA Medical Center; Departments of Medicine and Epidemiology at the Schools of Medicine and Public Health, University of Alabama at Birmingham, Birmingham, Alabama; Department of Anesthesiology and Pain Medicine, University of Washington; Rheumatology Research Swedish-Providence-St. Joseph Health Systems; University of Washington School of Medicine, Seattle, Washington, USA; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada. AC is supported by a postdoctoral fellowship of the Amsterdam Movement Sciences research institute; he was supported by OMERACT and by a European League Against Rheumatism bursary to attend the OMERACT 2018 conference. UK is funded by a postdoctoral fellowship of the Medical Faculty, Technical University Dresden, and also funded by a federal joint committee of Germany. EC is supported in part by Arthritis Research UK and Health and Care Research Wales through the CREATE Centre. The Parker Institute, Bispebjerg and Frederiksberg Hospital is supported by a core grant from the Oak Foundation (OCAY-13-309). PGC is supported in part by the NIHR Leeds Biomedical Research Centre. The views expressed are those of the author(s) and not necessarily those of the UK National Health Service, the NIHR, or the Department of Health. DCT is supported by the US National Institutes of Health (NIH) and the US Food and Drug Administration. EC has received research grants and/or served as member of advisory boards and speaker bureaus of AbbVie, Allergan, Amgen, AstraZeneca, Bio-Cancer, Biogen, BMS, Boehringer Ingelheim, Celgene, Chugai Pharma, Daiichi Sankyo, Eli Lilly, Ferring Pharmaceutical, GSK, Hospira, ISIS, Jazz Pharmaceuticals, Janssen, MedImmune, Merrimack Pharmaceutical, MSD, Napp, Novimmune, Novartis, ObsEva, Pfizer, Regeneron, Roche, R-Pharm, Sanofi, SynAct Pharma, Synovate, Tonix, and UCB. JAS has received consultant fees from Crealta/Horizon, Fidia, UBM LLC, Medscape, WebMD, the NIH, and the American College of Rheumatology. JAS is a member of the Veterans Affairs Rheumatology Field Advisory Committee. JAS is the editor and the Director of the UAB Cochrane Musculoskeletal Group Satellite Center on Network Meta-analysis. JAS served as a member of the American College of Rheumatology’s (ACR) Annual Meeting Planning Committee and Quality of Care Committees, the Chair of the ACR Meet-the-Professor, Workshop and Study Group Subcommittee and the co-chair of the ACR Criteria and Response Criteria subcommittee. JAS is a member of the executive of OMERACT, an organization that develops outcome measures in rheumatology and receives arms-length funding from 36 companies. DCT is the editor-in-chief of The Clinical Journal of Pain and serves as an industry advisor or consultant to AcelRx, GSK/Novartis, and Pfizer. A. Chiarotto, PhD, Postdoctoral Research Fellow, Department of Epidemiology and Biostatistics, VUmc, and Department of General Practice, Erasmus MC, University Medical Center Rotterdam; U. Kaiser, Dr. Rer. Nat., Postdoctoral Research Fellow and Principal Investigator, Comprehensive Pain Center, Medical Faculty of Technical University of Dresden; E. Choy, MD, Professor and Head of Rheumatology, Cardiff University; R. Christensen, PhD, Professor of Biostatistics and Clinical Epidemiology, The Rheumatology Research Unit, Department of Rheumatology, Odense University Hospital and University of Southern Denmark, and Head of Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital; P.G. Conaghan, MB BS, PhD, FRACP, FRCP, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Biomedical Research Centre; M. Cowern, OMERACT Patient Research Partner; M. Gill, BA, Australian National University, and Dragon Claw, and OMERACT Patient Research Partner; M. de Wit, PhD, OMERACT Patient Research Partner, and Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health; E. Gargon, PhD, Research Associate, Department of Biostatistics, University of Liverpool; B. Horgan, OMERACT Patient Research Partner; J.J. Kirkham, PhD, Senior Lecturer in Medical Statistics, Department of Biostatistics, University of Liverpool; L.S. Simon, MD, Principal, SDG LLC; J.A. Singh, MBBS, MPH, Endowed Professor of Medicine, University of Alabama at Birmingham; P. Tugwell, MD, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; D.C. Turk, PhD, John and Emma Bonica Endowed Chair and Professor of Anesthesiology and Pain Research, Department of Anesthesiology and Pain Medicine, University of Washington; P.J. Mease, MD, MACR, Director, Rheumatology Research, Swedish-Providence-St. Joseph Health Systems, and Clinical Professor, University of Washington School of Medicine. Address correspondence to Dr. A. Chiarotto, Department of Epidemiology and Biostatistics, Amsterdam Movement Sciences Research Institute, Amsterdam Public Health Research Institute, Amsterdam UMC (VU University Medical Center), Medical Faculty, F-vleugel, de Boelelaan 1089A, 1081HV Amsterdam, the Netherlands. E-mail: a.chiarotto@vu.nl. Accepted for publication March 8, 2019.
Maarten de Wit
From the Department of Epidemiology and Biostatistics, Amsterdam University Medical Centre (VUmc); VUmc, Department of Medical Humanities, Amsterdam Public Health (APH), Amsterdam; Department of General Practice, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands; Comprehensive Pain Center, University Hospital Carl Gustav Carus Dresden, Medical Faculty of the Technical University Dresden, Dresden, Germany; CREATE Centre, Section of Rheumatology, Division of Infection and Immunity, Cardiff University, Cardiff; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; UK National Institute for Health Research (NIHR) Leeds Biomedical Research Centre, Leeds; Versus Arthritis, Patron Her Royal Highness The Duchess of Cornwall, Chesterfield; MRC North West Hub for Trials Methodology Research, Department of Biostatistics, University of Liverpool, Liverpool, UK; Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen; The Rheumatology Research Unit, Department of Rheumatology, Odense University Hospital; Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark; Dragon Claw (Website for patients with rheumatic disease), New South Wales, Australia; Bingo and Fundraising Promotions, Mal Atwell Leisure Group, Willetton, Australia; SDG LLC, Cambridge, Massachusetts; Medicine Service, VA Medical Center; Departments of Medicine and Epidemiology at the Schools of Medicine and Public Health, University of Alabama at Birmingham, Birmingham, Alabama; Department of Anesthesiology and Pain Medicine, University of Washington; Rheumatology Research Swedish-Providence-St. Joseph Health Systems; University of Washington School of Medicine, Seattle, Washington, USA; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada. AC is supported by a postdoctoral fellowship of the Amsterdam Movement Sciences research institute; he was supported by OMERACT and by a European League Against Rheumatism bursary to attend the OMERACT 2018 conference. UK is funded by a postdoctoral fellowship of the Medical Faculty, Technical University Dresden, and also funded by a federal joint committee of Germany. EC is supported in part by Arthritis Research UK and Health and Care Research Wales through the CREATE Centre. The Parker Institute, Bispebjerg and Frederiksberg Hospital is supported by a core grant from the Oak Foundation (OCAY-13-309). PGC is supported in part by the NIHR Leeds Biomedical Research Centre. The views expressed are those of the author(s) and not necessarily those of the UK National Health Service, the NIHR, or the Department of Health. DCT is supported by the US National Institutes of Health (NIH) and the US Food and Drug Administration. EC has received research grants and/or served as member of advisory boards and speaker bureaus of AbbVie, Allergan, Amgen, AstraZeneca, Bio-Cancer, Biogen, BMS, Boehringer Ingelheim, Celgene, Chugai Pharma, Daiichi Sankyo, Eli Lilly, Ferring Pharmaceutical, GSK, Hospira, ISIS, Jazz Pharmaceuticals, Janssen, MedImmune, Merrimack Pharmaceutical, MSD, Napp, Novimmune, Novartis, ObsEva, Pfizer, Regeneron, Roche, R-Pharm, Sanofi, SynAct Pharma, Synovate, Tonix, and UCB. JAS has received consultant fees from Crealta/Horizon, Fidia, UBM LLC, Medscape, WebMD, the NIH, and the American College of Rheumatology. JAS is a member of the Veterans Affairs Rheumatology Field Advisory Committee. JAS is the editor and the Director of the UAB Cochrane Musculoskeletal Group Satellite Center on Network Meta-analysis. JAS served as a member of the American College of Rheumatology’s (ACR) Annual Meeting Planning Committee and Quality of Care Committees, the Chair of the ACR Meet-the-Professor, Workshop and Study Group Subcommittee and the co-chair of the ACR Criteria and Response Criteria subcommittee. JAS is a member of the executive of OMERACT, an organization that develops outcome measures in rheumatology and receives arms-length funding from 36 companies. DCT is the editor-in-chief of The Clinical Journal of Pain and serves as an industry advisor or consultant to AcelRx, GSK/Novartis, and Pfizer. A. Chiarotto, PhD, Postdoctoral Research Fellow, Department of Epidemiology and Biostatistics, VUmc, and Department of General Practice, Erasmus MC, University Medical Center Rotterdam; U. Kaiser, Dr. Rer. Nat., Postdoctoral Research Fellow and Principal Investigator, Comprehensive Pain Center, Medical Faculty of Technical University of Dresden; E. Choy, MD, Professor and Head of Rheumatology, Cardiff University; R. Christensen, PhD, Professor of Biostatistics and Clinical Epidemiology, The Rheumatology Research Unit, Department of Rheumatology, Odense University Hospital and University of Southern Denmark, and Head of Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital; P.G. Conaghan, MB BS, PhD, FRACP, FRCP, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Biomedical Research Centre; M. Cowern, OMERACT Patient Research Partner; M. Gill, BA, Australian National University, and Dragon Claw, and OMERACT Patient Research Partner; M. de Wit, PhD, OMERACT Patient Research Partner, and Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health; E. Gargon, PhD, Research Associate, Department of Biostatistics, University of Liverpool; B. Horgan, OMERACT Patient Research Partner; J.J. Kirkham, PhD, Senior Lecturer in Medical Statistics, Department of Biostatistics, University of Liverpool; L.S. Simon, MD, Principal, SDG LLC; J.A. Singh, MBBS, MPH, Endowed Professor of Medicine, University of Alabama at Birmingham; P. Tugwell, MD, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; D.C. Turk, PhD, John and Emma Bonica Endowed Chair and Professor of Anesthesiology and Pain Research, Department of Anesthesiology and Pain Medicine, University of Washington; P.J. Mease, MD, MACR, Director, Rheumatology Research, Swedish-Providence-St. Joseph Health Systems, and Clinical Professor, University of Washington School of Medicine. Address correspondence to Dr. A. Chiarotto, Department of Epidemiology and Biostatistics, Amsterdam Movement Sciences Research Institute, Amsterdam Public Health Research Institute, Amsterdam UMC (VU University Medical Center), Medical Faculty, F-vleugel, de Boelelaan 1089A, 1081HV Amsterdam, the Netherlands. E-mail: a.chiarotto@vu.nl. Accepted for publication March 8, 2019.
Elizabeth Gargon
From the Department of Epidemiology and Biostatistics, Amsterdam University Medical Centre (VUmc); VUmc, Department of Medical Humanities, Amsterdam Public Health (APH), Amsterdam; Department of General Practice, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands; Comprehensive Pain Center, University Hospital Carl Gustav Carus Dresden, Medical Faculty of the Technical University Dresden, Dresden, Germany; CREATE Centre, Section of Rheumatology, Division of Infection and Immunity, Cardiff University, Cardiff; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; UK National Institute for Health Research (NIHR) Leeds Biomedical Research Centre, Leeds; Versus Arthritis, Patron Her Royal Highness The Duchess of Cornwall, Chesterfield; MRC North West Hub for Trials Methodology Research, Department of Biostatistics, University of Liverpool, Liverpool, UK; Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen; The Rheumatology Research Unit, Department of Rheumatology, Odense University Hospital; Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark; Dragon Claw (Website for patients with rheumatic disease), New South Wales, Australia; Bingo and Fundraising Promotions, Mal Atwell Leisure Group, Willetton, Australia; SDG LLC, Cambridge, Massachusetts; Medicine Service, VA Medical Center; Departments of Medicine and Epidemiology at the Schools of Medicine and Public Health, University of Alabama at Birmingham, Birmingham, Alabama; Department of Anesthesiology and Pain Medicine, University of Washington; Rheumatology Research Swedish-Providence-St. Joseph Health Systems; University of Washington School of Medicine, Seattle, Washington, USA; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada. AC is supported by a postdoctoral fellowship of the Amsterdam Movement Sciences research institute; he was supported by OMERACT and by a European League Against Rheumatism bursary to attend the OMERACT 2018 conference. UK is funded by a postdoctoral fellowship of the Medical Faculty, Technical University Dresden, and also funded by a federal joint committee of Germany. EC is supported in part by Arthritis Research UK and Health and Care Research Wales through the CREATE Centre. The Parker Institute, Bispebjerg and Frederiksberg Hospital is supported by a core grant from the Oak Foundation (OCAY-13-309). PGC is supported in part by the NIHR Leeds Biomedical Research Centre. The views expressed are those of the author(s) and not necessarily those of the UK National Health Service, the NIHR, or the Department of Health. DCT is supported by the US National Institutes of Health (NIH) and the US Food and Drug Administration. EC has received research grants and/or served as member of advisory boards and speaker bureaus of AbbVie, Allergan, Amgen, AstraZeneca, Bio-Cancer, Biogen, BMS, Boehringer Ingelheim, Celgene, Chugai Pharma, Daiichi Sankyo, Eli Lilly, Ferring Pharmaceutical, GSK, Hospira, ISIS, Jazz Pharmaceuticals, Janssen, MedImmune, Merrimack Pharmaceutical, MSD, Napp, Novimmune, Novartis, ObsEva, Pfizer, Regeneron, Roche, R-Pharm, Sanofi, SynAct Pharma, Synovate, Tonix, and UCB. JAS has received consultant fees from Crealta/Horizon, Fidia, UBM LLC, Medscape, WebMD, the NIH, and the American College of Rheumatology. JAS is a member of the Veterans Affairs Rheumatology Field Advisory Committee. JAS is the editor and the Director of the UAB Cochrane Musculoskeletal Group Satellite Center on Network Meta-analysis. JAS served as a member of the American College of Rheumatology’s (ACR) Annual Meeting Planning Committee and Quality of Care Committees, the Chair of the ACR Meet-the-Professor, Workshop and Study Group Subcommittee and the co-chair of the ACR Criteria and Response Criteria subcommittee. JAS is a member of the executive of OMERACT, an organization that develops outcome measures in rheumatology and receives arms-length funding from 36 companies. DCT is the editor-in-chief of The Clinical Journal of Pain and serves as an industry advisor or consultant to AcelRx, GSK/Novartis, and Pfizer. A. Chiarotto, PhD, Postdoctoral Research Fellow, Department of Epidemiology and Biostatistics, VUmc, and Department of General Practice, Erasmus MC, University Medical Center Rotterdam; U. Kaiser, Dr. Rer. Nat., Postdoctoral Research Fellow and Principal Investigator, Comprehensive Pain Center, Medical Faculty of Technical University of Dresden; E. Choy, MD, Professor and Head of Rheumatology, Cardiff University; R. Christensen, PhD, Professor of Biostatistics and Clinical Epidemiology, The Rheumatology Research Unit, Department of Rheumatology, Odense University Hospital and University of Southern Denmark, and Head of Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital; P.G. Conaghan, MB BS, PhD, FRACP, FRCP, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Biomedical Research Centre; M. Cowern, OMERACT Patient Research Partner; M. Gill, BA, Australian National University, and Dragon Claw, and OMERACT Patient Research Partner; M. de Wit, PhD, OMERACT Patient Research Partner, and Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health; E. Gargon, PhD, Research Associate, Department of Biostatistics, University of Liverpool; B. Horgan, OMERACT Patient Research Partner; J.J. Kirkham, PhD, Senior Lecturer in Medical Statistics, Department of Biostatistics, University of Liverpool; L.S. Simon, MD, Principal, SDG LLC; J.A. Singh, MBBS, MPH, Endowed Professor of Medicine, University of Alabama at Birmingham; P. Tugwell, MD, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; D.C. Turk, PhD, John and Emma Bonica Endowed Chair and Professor of Anesthesiology and Pain Research, Department of Anesthesiology and Pain Medicine, University of Washington; P.J. Mease, MD, MACR, Director, Rheumatology Research, Swedish-Providence-St. Joseph Health Systems, and Clinical Professor, University of Washington School of Medicine. Address correspondence to Dr. A. Chiarotto, Department of Epidemiology and Biostatistics, Amsterdam Movement Sciences Research Institute, Amsterdam Public Health Research Institute, Amsterdam UMC (VU University Medical Center), Medical Faculty, F-vleugel, de Boelelaan 1089A, 1081HV Amsterdam, the Netherlands. E-mail: a.chiarotto@vu.nl. Accepted for publication March 8, 2019.
Ben Horgan
From the Department of Epidemiology and Biostatistics, Amsterdam University Medical Centre (VUmc); VUmc, Department of Medical Humanities, Amsterdam Public Health (APH), Amsterdam; Department of General Practice, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands; Comprehensive Pain Center, University Hospital Carl Gustav Carus Dresden, Medical Faculty of the Technical University Dresden, Dresden, Germany; CREATE Centre, Section of Rheumatology, Division of Infection and Immunity, Cardiff University, Cardiff; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; UK National Institute for Health Research (NIHR) Leeds Biomedical Research Centre, Leeds; Versus Arthritis, Patron Her Royal Highness The Duchess of Cornwall, Chesterfield; MRC North West Hub for Trials Methodology Research, Department of Biostatistics, University of Liverpool, Liverpool, UK; Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen; The Rheumatology Research Unit, Department of Rheumatology, Odense University Hospital; Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark; Dragon Claw (Website for patients with rheumatic disease), New South Wales, Australia; Bingo and Fundraising Promotions, Mal Atwell Leisure Group, Willetton, Australia; SDG LLC, Cambridge, Massachusetts; Medicine Service, VA Medical Center; Departments of Medicine and Epidemiology at the Schools of Medicine and Public Health, University of Alabama at Birmingham, Birmingham, Alabama; Department of Anesthesiology and Pain Medicine, University of Washington; Rheumatology Research Swedish-Providence-St. Joseph Health Systems; University of Washington School of Medicine, Seattle, Washington, USA; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada. AC is supported by a postdoctoral fellowship of the Amsterdam Movement Sciences research institute; he was supported by OMERACT and by a European League Against Rheumatism bursary to attend the OMERACT 2018 conference. UK is funded by a postdoctoral fellowship of the Medical Faculty, Technical University Dresden, and also funded by a federal joint committee of Germany. EC is supported in part by Arthritis Research UK and Health and Care Research Wales through the CREATE Centre. The Parker Institute, Bispebjerg and Frederiksberg Hospital is supported by a core grant from the Oak Foundation (OCAY-13-309). PGC is supported in part by the NIHR Leeds Biomedical Research Centre. The views expressed are those of the author(s) and not necessarily those of the UK National Health Service, the NIHR, or the Department of Health. DCT is supported by the US National Institutes of Health (NIH) and the US Food and Drug Administration. EC has received research grants and/or served as member of advisory boards and speaker bureaus of AbbVie, Allergan, Amgen, AstraZeneca, Bio-Cancer, Biogen, BMS, Boehringer Ingelheim, Celgene, Chugai Pharma, Daiichi Sankyo, Eli Lilly, Ferring Pharmaceutical, GSK, Hospira, ISIS, Jazz Pharmaceuticals, Janssen, MedImmune, Merrimack Pharmaceutical, MSD, Napp, Novimmune, Novartis, ObsEva, Pfizer, Regeneron, Roche, R-Pharm, Sanofi, SynAct Pharma, Synovate, Tonix, and UCB. JAS has received consultant fees from Crealta/Horizon, Fidia, UBM LLC, Medscape, WebMD, the NIH, and the American College of Rheumatology. JAS is a member of the Veterans Affairs Rheumatology Field Advisory Committee. JAS is the editor and the Director of the UAB Cochrane Musculoskeletal Group Satellite Center on Network Meta-analysis. JAS served as a member of the American College of Rheumatology’s (ACR) Annual Meeting Planning Committee and Quality of Care Committees, the Chair of the ACR Meet-the-Professor, Workshop and Study Group Subcommittee and the co-chair of the ACR Criteria and Response Criteria subcommittee. JAS is a member of the executive of OMERACT, an organization that develops outcome measures in rheumatology and receives arms-length funding from 36 companies. DCT is the editor-in-chief of The Clinical Journal of Pain and serves as an industry advisor or consultant to AcelRx, GSK/Novartis, and Pfizer. A. Chiarotto, PhD, Postdoctoral Research Fellow, Department of Epidemiology and Biostatistics, VUmc, and Department of General Practice, Erasmus MC, University Medical Center Rotterdam; U. Kaiser, Dr. Rer. Nat., Postdoctoral Research Fellow and Principal Investigator, Comprehensive Pain Center, Medical Faculty of Technical University of Dresden; E. Choy, MD, Professor and Head of Rheumatology, Cardiff University; R. Christensen, PhD, Professor of Biostatistics and Clinical Epidemiology, The Rheumatology Research Unit, Department of Rheumatology, Odense University Hospital and University of Southern Denmark, and Head of Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital; P.G. Conaghan, MB BS, PhD, FRACP, FRCP, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Biomedical Research Centre; M. Cowern, OMERACT Patient Research Partner; M. Gill, BA, Australian National University, and Dragon Claw, and OMERACT Patient Research Partner; M. de Wit, PhD, OMERACT Patient Research Partner, and Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health; E. Gargon, PhD, Research Associate, Department of Biostatistics, University of Liverpool; B. Horgan, OMERACT Patient Research Partner; J.J. Kirkham, PhD, Senior Lecturer in Medical Statistics, Department of Biostatistics, University of Liverpool; L.S. Simon, MD, Principal, SDG LLC; J.A. Singh, MBBS, MPH, Endowed Professor of Medicine, University of Alabama at Birmingham; P. Tugwell, MD, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; D.C. Turk, PhD, John and Emma Bonica Endowed Chair and Professor of Anesthesiology and Pain Research, Department of Anesthesiology and Pain Medicine, University of Washington; P.J. Mease, MD, MACR, Director, Rheumatology Research, Swedish-Providence-St. Joseph Health Systems, and Clinical Professor, University of Washington School of Medicine. Address correspondence to Dr. A. Chiarotto, Department of Epidemiology and Biostatistics, Amsterdam Movement Sciences Research Institute, Amsterdam Public Health Research Institute, Amsterdam UMC (VU University Medical Center), Medical Faculty, F-vleugel, de Boelelaan 1089A, 1081HV Amsterdam, the Netherlands. E-mail: a.chiarotto@vu.nl. Accepted for publication March 8, 2019.
Jamie J. Kirkham
From the Department of Epidemiology and Biostatistics, Amsterdam University Medical Centre (VUmc); VUmc, Department of Medical Humanities, Amsterdam Public Health (APH), Amsterdam; Department of General Practice, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands; Comprehensive Pain Center, University Hospital Carl Gustav Carus Dresden, Medical Faculty of the Technical University Dresden, Dresden, Germany; CREATE Centre, Section of Rheumatology, Division of Infection and Immunity, Cardiff University, Cardiff; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; UK National Institute for Health Research (NIHR) Leeds Biomedical Research Centre, Leeds; Versus Arthritis, Patron Her Royal Highness The Duchess of Cornwall, Chesterfield; MRC North West Hub for Trials Methodology Research, Department of Biostatistics, University of Liverpool, Liverpool, UK; Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen; The Rheumatology Research Unit, Department of Rheumatology, Odense University Hospital; Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark; Dragon Claw (Website for patients with rheumatic disease), New South Wales, Australia; Bingo and Fundraising Promotions, Mal Atwell Leisure Group, Willetton, Australia; SDG LLC, Cambridge, Massachusetts; Medicine Service, VA Medical Center; Departments of Medicine and Epidemiology at the Schools of Medicine and Public Health, University of Alabama at Birmingham, Birmingham, Alabama; Department of Anesthesiology and Pain Medicine, University of Washington; Rheumatology Research Swedish-Providence-St. Joseph Health Systems; University of Washington School of Medicine, Seattle, Washington, USA; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada. AC is supported by a postdoctoral fellowship of the Amsterdam Movement Sciences research institute; he was supported by OMERACT and by a European League Against Rheumatism bursary to attend the OMERACT 2018 conference. UK is funded by a postdoctoral fellowship of the Medical Faculty, Technical University Dresden, and also funded by a federal joint committee of Germany. EC is supported in part by Arthritis Research UK and Health and Care Research Wales through the CREATE Centre. The Parker Institute, Bispebjerg and Frederiksberg Hospital is supported by a core grant from the Oak Foundation (OCAY-13-309). PGC is supported in part by the NIHR Leeds Biomedical Research Centre. The views expressed are those of the author(s) and not necessarily those of the UK National Health Service, the NIHR, or the Department of Health. DCT is supported by the US National Institutes of Health (NIH) and the US Food and Drug Administration. EC has received research grants and/or served as member of advisory boards and speaker bureaus of AbbVie, Allergan, Amgen, AstraZeneca, Bio-Cancer, Biogen, BMS, Boehringer Ingelheim, Celgene, Chugai Pharma, Daiichi Sankyo, Eli Lilly, Ferring Pharmaceutical, GSK, Hospira, ISIS, Jazz Pharmaceuticals, Janssen, MedImmune, Merrimack Pharmaceutical, MSD, Napp, Novimmune, Novartis, ObsEva, Pfizer, Regeneron, Roche, R-Pharm, Sanofi, SynAct Pharma, Synovate, Tonix, and UCB. JAS has received consultant fees from Crealta/Horizon, Fidia, UBM LLC, Medscape, WebMD, the NIH, and the American College of Rheumatology. JAS is a member of the Veterans Affairs Rheumatology Field Advisory Committee. JAS is the editor and the Director of the UAB Cochrane Musculoskeletal Group Satellite Center on Network Meta-analysis. JAS served as a member of the American College of Rheumatology’s (ACR) Annual Meeting Planning Committee and Quality of Care Committees, the Chair of the ACR Meet-the-Professor, Workshop and Study Group Subcommittee and the co-chair of the ACR Criteria and Response Criteria subcommittee. JAS is a member of the executive of OMERACT, an organization that develops outcome measures in rheumatology and receives arms-length funding from 36 companies. DCT is the editor-in-chief of The Clinical Journal of Pain and serves as an industry advisor or consultant to AcelRx, GSK/Novartis, and Pfizer. A. Chiarotto, PhD, Postdoctoral Research Fellow, Department of Epidemiology and Biostatistics, VUmc, and Department of General Practice, Erasmus MC, University Medical Center Rotterdam; U. Kaiser, Dr. Rer. Nat., Postdoctoral Research Fellow and Principal Investigator, Comprehensive Pain Center, Medical Faculty of Technical University of Dresden; E. Choy, MD, Professor and Head of Rheumatology, Cardiff University; R. Christensen, PhD, Professor of Biostatistics and Clinical Epidemiology, The Rheumatology Research Unit, Department of Rheumatology, Odense University Hospital and University of Southern Denmark, and Head of Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital; P.G. Conaghan, MB BS, PhD, FRACP, FRCP, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Biomedical Research Centre; M. Cowern, OMERACT Patient Research Partner; M. Gill, BA, Australian National University, and Dragon Claw, and OMERACT Patient Research Partner; M. de Wit, PhD, OMERACT Patient Research Partner, and Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health; E. Gargon, PhD, Research Associate, Department of Biostatistics, University of Liverpool; B. Horgan, OMERACT Patient Research Partner; J.J. Kirkham, PhD, Senior Lecturer in Medical Statistics, Department of Biostatistics, University of Liverpool; L.S. Simon, MD, Principal, SDG LLC; J.A. Singh, MBBS, MPH, Endowed Professor of Medicine, University of Alabama at Birmingham; P. Tugwell, MD, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; D.C. Turk, PhD, John and Emma Bonica Endowed Chair and Professor of Anesthesiology and Pain Research, Department of Anesthesiology and Pain Medicine, University of Washington; P.J. Mease, MD, MACR, Director, Rheumatology Research, Swedish-Providence-St. Joseph Health Systems, and Clinical Professor, University of Washington School of Medicine. Address correspondence to Dr. A. Chiarotto, Department of Epidemiology and Biostatistics, Amsterdam Movement Sciences Research Institute, Amsterdam Public Health Research Institute, Amsterdam UMC (VU University Medical Center), Medical Faculty, F-vleugel, de Boelelaan 1089A, 1081HV Amsterdam, the Netherlands. E-mail: a.chiarotto@vu.nl. Accepted for publication March 8, 2019.
Lee S. Simon
From the Department of Epidemiology and Biostatistics, Amsterdam University Medical Centre (VUmc); VUmc, Department of Medical Humanities, Amsterdam Public Health (APH), Amsterdam; Department of General Practice, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands; Comprehensive Pain Center, University Hospital Carl Gustav Carus Dresden, Medical Faculty of the Technical University Dresden, Dresden, Germany; CREATE Centre, Section of Rheumatology, Division of Infection and Immunity, Cardiff University, Cardiff; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; UK National Institute for Health Research (NIHR) Leeds Biomedical Research Centre, Leeds; Versus Arthritis, Patron Her Royal Highness The Duchess of Cornwall, Chesterfield; MRC North West Hub for Trials Methodology Research, Department of Biostatistics, University of Liverpool, Liverpool, UK; Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen; The Rheumatology Research Unit, Department of Rheumatology, Odense University Hospital; Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark; Dragon Claw (Website for patients with rheumatic disease), New South Wales, Australia; Bingo and Fundraising Promotions, Mal Atwell Leisure Group, Willetton, Australia; SDG LLC, Cambridge, Massachusetts; Medicine Service, VA Medical Center; Departments of Medicine and Epidemiology at the Schools of Medicine and Public Health, University of Alabama at Birmingham, Birmingham, Alabama; Department of Anesthesiology and Pain Medicine, University of Washington; Rheumatology Research Swedish-Providence-St. Joseph Health Systems; University of Washington School of Medicine, Seattle, Washington, USA; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada. AC is supported by a postdoctoral fellowship of the Amsterdam Movement Sciences research institute; he was supported by OMERACT and by a European League Against Rheumatism bursary to attend the OMERACT 2018 conference. UK is funded by a postdoctoral fellowship of the Medical Faculty, Technical University Dresden, and also funded by a federal joint committee of Germany. EC is supported in part by Arthritis Research UK and Health and Care Research Wales through the CREATE Centre. The Parker Institute, Bispebjerg and Frederiksberg Hospital is supported by a core grant from the Oak Foundation (OCAY-13-309). PGC is supported in part by the NIHR Leeds Biomedical Research Centre. The views expressed are those of the author(s) and not necessarily those of the UK National Health Service, the NIHR, or the Department of Health. DCT is supported by the US National Institutes of Health (NIH) and the US Food and Drug Administration. EC has received research grants and/or served as member of advisory boards and speaker bureaus of AbbVie, Allergan, Amgen, AstraZeneca, Bio-Cancer, Biogen, BMS, Boehringer Ingelheim, Celgene, Chugai Pharma, Daiichi Sankyo, Eli Lilly, Ferring Pharmaceutical, GSK, Hospira, ISIS, Jazz Pharmaceuticals, Janssen, MedImmune, Merrimack Pharmaceutical, MSD, Napp, Novimmune, Novartis, ObsEva, Pfizer, Regeneron, Roche, R-Pharm, Sanofi, SynAct Pharma, Synovate, Tonix, and UCB. JAS has received consultant fees from Crealta/Horizon, Fidia, UBM LLC, Medscape, WebMD, the NIH, and the American College of Rheumatology. JAS is a member of the Veterans Affairs Rheumatology Field Advisory Committee. JAS is the editor and the Director of the UAB Cochrane Musculoskeletal Group Satellite Center on Network Meta-analysis. JAS served as a member of the American College of Rheumatology’s (ACR) Annual Meeting Planning Committee and Quality of Care Committees, the Chair of the ACR Meet-the-Professor, Workshop and Study Group Subcommittee and the co-chair of the ACR Criteria and Response Criteria subcommittee. JAS is a member of the executive of OMERACT, an organization that develops outcome measures in rheumatology and receives arms-length funding from 36 companies. DCT is the editor-in-chief of The Clinical Journal of Pain and serves as an industry advisor or consultant to AcelRx, GSK/Novartis, and Pfizer. A. Chiarotto, PhD, Postdoctoral Research Fellow, Department of Epidemiology and Biostatistics, VUmc, and Department of General Practice, Erasmus MC, University Medical Center Rotterdam; U. Kaiser, Dr. Rer. Nat., Postdoctoral Research Fellow and Principal Investigator, Comprehensive Pain Center, Medical Faculty of Technical University of Dresden; E. Choy, MD, Professor and Head of Rheumatology, Cardiff University; R. Christensen, PhD, Professor of Biostatistics and Clinical Epidemiology, The Rheumatology Research Unit, Department of Rheumatology, Odense University Hospital and University of Southern Denmark, and Head of Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital; P.G. Conaghan, MB BS, PhD, FRACP, FRCP, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Biomedical Research Centre; M. Cowern, OMERACT Patient Research Partner; M. Gill, BA, Australian National University, and Dragon Claw, and OMERACT Patient Research Partner; M. de Wit, PhD, OMERACT Patient Research Partner, and Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health; E. Gargon, PhD, Research Associate, Department of Biostatistics, University of Liverpool; B. Horgan, OMERACT Patient Research Partner; J.J. Kirkham, PhD, Senior Lecturer in Medical Statistics, Department of Biostatistics, University of Liverpool; L.S. Simon, MD, Principal, SDG LLC; J.A. Singh, MBBS, MPH, Endowed Professor of Medicine, University of Alabama at Birmingham; P. Tugwell, MD, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; D.C. Turk, PhD, John and Emma Bonica Endowed Chair and Professor of Anesthesiology and Pain Research, Department of Anesthesiology and Pain Medicine, University of Washington; P.J. Mease, MD, MACR, Director, Rheumatology Research, Swedish-Providence-St. Joseph Health Systems, and Clinical Professor, University of Washington School of Medicine. Address correspondence to Dr. A. Chiarotto, Department of Epidemiology and Biostatistics, Amsterdam Movement Sciences Research Institute, Amsterdam Public Health Research Institute, Amsterdam UMC (VU University Medical Center), Medical Faculty, F-vleugel, de Boelelaan 1089A, 1081HV Amsterdam, the Netherlands. E-mail: a.chiarotto@vu.nl. Accepted for publication March 8, 2019.
Jasvinder A. Singh
From the Department of Epidemiology and Biostatistics, Amsterdam University Medical Centre (VUmc); VUmc, Department of Medical Humanities, Amsterdam Public Health (APH), Amsterdam; Department of General Practice, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands; Comprehensive Pain Center, University Hospital Carl Gustav Carus Dresden, Medical Faculty of the Technical University Dresden, Dresden, Germany; CREATE Centre, Section of Rheumatology, Division of Infection and Immunity, Cardiff University, Cardiff; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; UK National Institute for Health Research (NIHR) Leeds Biomedical Research Centre, Leeds; Versus Arthritis, Patron Her Royal Highness The Duchess of Cornwall, Chesterfield; MRC North West Hub for Trials Methodology Research, Department of Biostatistics, University of Liverpool, Liverpool, UK; Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen; The Rheumatology Research Unit, Department of Rheumatology, Odense University Hospital; Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark; Dragon Claw (Website for patients with rheumatic disease), New South Wales, Australia; Bingo and Fundraising Promotions, Mal Atwell Leisure Group, Willetton, Australia; SDG LLC, Cambridge, Massachusetts; Medicine Service, VA Medical Center; Departments of Medicine and Epidemiology at the Schools of Medicine and Public Health, University of Alabama at Birmingham, Birmingham, Alabama; Department of Anesthesiology and Pain Medicine, University of Washington; Rheumatology Research Swedish-Providence-St. Joseph Health Systems; University of Washington School of Medicine, Seattle, Washington, USA; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada. AC is supported by a postdoctoral fellowship of the Amsterdam Movement Sciences research institute; he was supported by OMERACT and by a European League Against Rheumatism bursary to attend the OMERACT 2018 conference. UK is funded by a postdoctoral fellowship of the Medical Faculty, Technical University Dresden, and also funded by a federal joint committee of Germany. EC is supported in part by Arthritis Research UK and Health and Care Research Wales through the CREATE Centre. The Parker Institute, Bispebjerg and Frederiksberg Hospital is supported by a core grant from the Oak Foundation (OCAY-13-309). PGC is supported in part by the NIHR Leeds Biomedical Research Centre. The views expressed are those of the author(s) and not necessarily those of the UK National Health Service, the NIHR, or the Department of Health. DCT is supported by the US National Institutes of Health (NIH) and the US Food and Drug Administration. EC has received research grants and/or served as member of advisory boards and speaker bureaus of AbbVie, Allergan, Amgen, AstraZeneca, Bio-Cancer, Biogen, BMS, Boehringer Ingelheim, Celgene, Chugai Pharma, Daiichi Sankyo, Eli Lilly, Ferring Pharmaceutical, GSK, Hospira, ISIS, Jazz Pharmaceuticals, Janssen, MedImmune, Merrimack Pharmaceutical, MSD, Napp, Novimmune, Novartis, ObsEva, Pfizer, Regeneron, Roche, R-Pharm, Sanofi, SynAct Pharma, Synovate, Tonix, and UCB. JAS has received consultant fees from Crealta/Horizon, Fidia, UBM LLC, Medscape, WebMD, the NIH, and the American College of Rheumatology. JAS is a member of the Veterans Affairs Rheumatology Field Advisory Committee. JAS is the editor and the Director of the UAB Cochrane Musculoskeletal Group Satellite Center on Network Meta-analysis. JAS served as a member of the American College of Rheumatology’s (ACR) Annual Meeting Planning Committee and Quality of Care Committees, the Chair of the ACR Meet-the-Professor, Workshop and Study Group Subcommittee and the co-chair of the ACR Criteria and Response Criteria subcommittee. JAS is a member of the executive of OMERACT, an organization that develops outcome measures in rheumatology and receives arms-length funding from 36 companies. DCT is the editor-in-chief of The Clinical Journal of Pain and serves as an industry advisor or consultant to AcelRx, GSK/Novartis, and Pfizer. A. Chiarotto, PhD, Postdoctoral Research Fellow, Department of Epidemiology and Biostatistics, VUmc, and Department of General Practice, Erasmus MC, University Medical Center Rotterdam; U. Kaiser, Dr. Rer. Nat., Postdoctoral Research Fellow and Principal Investigator, Comprehensive Pain Center, Medical Faculty of Technical University of Dresden; E. Choy, MD, Professor and Head of Rheumatology, Cardiff University; R. Christensen, PhD, Professor of Biostatistics and Clinical Epidemiology, The Rheumatology Research Unit, Department of Rheumatology, Odense University Hospital and University of Southern Denmark, and Head of Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital; P.G. Conaghan, MB BS, PhD, FRACP, FRCP, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Biomedical Research Centre; M. Cowern, OMERACT Patient Research Partner; M. Gill, BA, Australian National University, and Dragon Claw, and OMERACT Patient Research Partner; M. de Wit, PhD, OMERACT Patient Research Partner, and Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health; E. Gargon, PhD, Research Associate, Department of Biostatistics, University of Liverpool; B. Horgan, OMERACT Patient Research Partner; J.J. Kirkham, PhD, Senior Lecturer in Medical Statistics, Department of Biostatistics, University of Liverpool; L.S. Simon, MD, Principal, SDG LLC; J.A. Singh, MBBS, MPH, Endowed Professor of Medicine, University of Alabama at Birmingham; P. Tugwell, MD, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; D.C. Turk, PhD, John and Emma Bonica Endowed Chair and Professor of Anesthesiology and Pain Research, Department of Anesthesiology and Pain Medicine, University of Washington; P.J. Mease, MD, MACR, Director, Rheumatology Research, Swedish-Providence-St. Joseph Health Systems, and Clinical Professor, University of Washington School of Medicine. Address correspondence to Dr. A. Chiarotto, Department of Epidemiology and Biostatistics, Amsterdam Movement Sciences Research Institute, Amsterdam Public Health Research Institute, Amsterdam UMC (VU University Medical Center), Medical Faculty, F-vleugel, de Boelelaan 1089A, 1081HV Amsterdam, the Netherlands. E-mail: a.chiarotto@vu.nl. Accepted for publication March 8, 2019.
Peter Tugwell
From the Department of Epidemiology and Biostatistics, Amsterdam University Medical Centre (VUmc); VUmc, Department of Medical Humanities, Amsterdam Public Health (APH), Amsterdam; Department of General Practice, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands; Comprehensive Pain Center, University Hospital Carl Gustav Carus Dresden, Medical Faculty of the Technical University Dresden, Dresden, Germany; CREATE Centre, Section of Rheumatology, Division of Infection and Immunity, Cardiff University, Cardiff; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; UK National Institute for Health Research (NIHR) Leeds Biomedical Research Centre, Leeds; Versus Arthritis, Patron Her Royal Highness The Duchess of Cornwall, Chesterfield; MRC North West Hub for Trials Methodology Research, Department of Biostatistics, University of Liverpool, Liverpool, UK; Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen; The Rheumatology Research Unit, Department of Rheumatology, Odense University Hospital; Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark; Dragon Claw (Website for patients with rheumatic disease), New South Wales, Australia; Bingo and Fundraising Promotions, Mal Atwell Leisure Group, Willetton, Australia; SDG LLC, Cambridge, Massachusetts; Medicine Service, VA Medical Center; Departments of Medicine and Epidemiology at the Schools of Medicine and Public Health, University of Alabama at Birmingham, Birmingham, Alabama; Department of Anesthesiology and Pain Medicine, University of Washington; Rheumatology Research Swedish-Providence-St. Joseph Health Systems; University of Washington School of Medicine, Seattle, Washington, USA; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada. AC is supported by a postdoctoral fellowship of the Amsterdam Movement Sciences research institute; he was supported by OMERACT and by a European League Against Rheumatism bursary to attend the OMERACT 2018 conference. UK is funded by a postdoctoral fellowship of the Medical Faculty, Technical University Dresden, and also funded by a federal joint committee of Germany. EC is supported in part by Arthritis Research UK and Health and Care Research Wales through the CREATE Centre. The Parker Institute, Bispebjerg and Frederiksberg Hospital is supported by a core grant from the Oak Foundation (OCAY-13-309). PGC is supported in part by the NIHR Leeds Biomedical Research Centre. The views expressed are those of the author(s) and not necessarily those of the UK National Health Service, the NIHR, or the Department of Health. DCT is supported by the US National Institutes of Health (NIH) and the US Food and Drug Administration. EC has received research grants and/or served as member of advisory boards and speaker bureaus of AbbVie, Allergan, Amgen, AstraZeneca, Bio-Cancer, Biogen, BMS, Boehringer Ingelheim, Celgene, Chugai Pharma, Daiichi Sankyo, Eli Lilly, Ferring Pharmaceutical, GSK, Hospira, ISIS, Jazz Pharmaceuticals, Janssen, MedImmune, Merrimack Pharmaceutical, MSD, Napp, Novimmune, Novartis, ObsEva, Pfizer, Regeneron, Roche, R-Pharm, Sanofi, SynAct Pharma, Synovate, Tonix, and UCB. JAS has received consultant fees from Crealta/Horizon, Fidia, UBM LLC, Medscape, WebMD, the NIH, and the American College of Rheumatology. JAS is a member of the Veterans Affairs Rheumatology Field Advisory Committee. JAS is the editor and the Director of the UAB Cochrane Musculoskeletal Group Satellite Center on Network Meta-analysis. JAS served as a member of the American College of Rheumatology’s (ACR) Annual Meeting Planning Committee and Quality of Care Committees, the Chair of the ACR Meet-the-Professor, Workshop and Study Group Subcommittee and the co-chair of the ACR Criteria and Response Criteria subcommittee. JAS is a member of the executive of OMERACT, an organization that develops outcome measures in rheumatology and receives arms-length funding from 36 companies. DCT is the editor-in-chief of The Clinical Journal of Pain and serves as an industry advisor or consultant to AcelRx, GSK/Novartis, and Pfizer. A. Chiarotto, PhD, Postdoctoral Research Fellow, Department of Epidemiology and Biostatistics, VUmc, and Department of General Practice, Erasmus MC, University Medical Center Rotterdam; U. Kaiser, Dr. Rer. Nat., Postdoctoral Research Fellow and Principal Investigator, Comprehensive Pain Center, Medical Faculty of Technical University of Dresden; E. Choy, MD, Professor and Head of Rheumatology, Cardiff University; R. Christensen, PhD, Professor of Biostatistics and Clinical Epidemiology, The Rheumatology Research Unit, Department of Rheumatology, Odense University Hospital and University of Southern Denmark, and Head of Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital; P.G. Conaghan, MB BS, PhD, FRACP, FRCP, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Biomedical Research Centre; M. Cowern, OMERACT Patient Research Partner; M. Gill, BA, Australian National University, and Dragon Claw, and OMERACT Patient Research Partner; M. de Wit, PhD, OMERACT Patient Research Partner, and Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health; E. Gargon, PhD, Research Associate, Department of Biostatistics, University of Liverpool; B. Horgan, OMERACT Patient Research Partner; J.J. Kirkham, PhD, Senior Lecturer in Medical Statistics, Department of Biostatistics, University of Liverpool; L.S. Simon, MD, Principal, SDG LLC; J.A. Singh, MBBS, MPH, Endowed Professor of Medicine, University of Alabama at Birmingham; P. Tugwell, MD, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; D.C. Turk, PhD, John and Emma Bonica Endowed Chair and Professor of Anesthesiology and Pain Research, Department of Anesthesiology and Pain Medicine, University of Washington; P.J. Mease, MD, MACR, Director, Rheumatology Research, Swedish-Providence-St. Joseph Health Systems, and Clinical Professor, University of Washington School of Medicine. Address correspondence to Dr. A. Chiarotto, Department of Epidemiology and Biostatistics, Amsterdam Movement Sciences Research Institute, Amsterdam Public Health Research Institute, Amsterdam UMC (VU University Medical Center), Medical Faculty, F-vleugel, de Boelelaan 1089A, 1081HV Amsterdam, the Netherlands. E-mail: a.chiarotto@vu.nl. Accepted for publication March 8, 2019.
Dennis C. Turk
From the Department of Epidemiology and Biostatistics, Amsterdam University Medical Centre (VUmc); VUmc, Department of Medical Humanities, Amsterdam Public Health (APH), Amsterdam; Department of General Practice, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands; Comprehensive Pain Center, University Hospital Carl Gustav Carus Dresden, Medical Faculty of the Technical University Dresden, Dresden, Germany; CREATE Centre, Section of Rheumatology, Division of Infection and Immunity, Cardiff University, Cardiff; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; UK National Institute for Health Research (NIHR) Leeds Biomedical Research Centre, Leeds; Versus Arthritis, Patron Her Royal Highness The Duchess of Cornwall, Chesterfield; MRC North West Hub for Trials Methodology Research, Department of Biostatistics, University of Liverpool, Liverpool, UK; Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen; The Rheumatology Research Unit, Department of Rheumatology, Odense University Hospital; Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark; Dragon Claw (Website for patients with rheumatic disease), New South Wales, Australia; Bingo and Fundraising Promotions, Mal Atwell Leisure Group, Willetton, Australia; SDG LLC, Cambridge, Massachusetts; Medicine Service, VA Medical Center; Departments of Medicine and Epidemiology at the Schools of Medicine and Public Health, University of Alabama at Birmingham, Birmingham, Alabama; Department of Anesthesiology and Pain Medicine, University of Washington; Rheumatology Research Swedish-Providence-St. Joseph Health Systems; University of Washington School of Medicine, Seattle, Washington, USA; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada. AC is supported by a postdoctoral fellowship of the Amsterdam Movement Sciences research institute; he was supported by OMERACT and by a European League Against Rheumatism bursary to attend the OMERACT 2018 conference. UK is funded by a postdoctoral fellowship of the Medical Faculty, Technical University Dresden, and also funded by a federal joint committee of Germany. EC is supported in part by Arthritis Research UK and Health and Care Research Wales through the CREATE Centre. The Parker Institute, Bispebjerg and Frederiksberg Hospital is supported by a core grant from the Oak Foundation (OCAY-13-309). PGC is supported in part by the NIHR Leeds Biomedical Research Centre. The views expressed are those of the author(s) and not necessarily those of the UK National Health Service, the NIHR, or the Department of Health. DCT is supported by the US National Institutes of Health (NIH) and the US Food and Drug Administration. EC has received research grants and/or served as member of advisory boards and speaker bureaus of AbbVie, Allergan, Amgen, AstraZeneca, Bio-Cancer, Biogen, BMS, Boehringer Ingelheim, Celgene, Chugai Pharma, Daiichi Sankyo, Eli Lilly, Ferring Pharmaceutical, GSK, Hospira, ISIS, Jazz Pharmaceuticals, Janssen, MedImmune, Merrimack Pharmaceutical, MSD, Napp, Novimmune, Novartis, ObsEva, Pfizer, Regeneron, Roche, R-Pharm, Sanofi, SynAct Pharma, Synovate, Tonix, and UCB. JAS has received consultant fees from Crealta/Horizon, Fidia, UBM LLC, Medscape, WebMD, the NIH, and the American College of Rheumatology. JAS is a member of the Veterans Affairs Rheumatology Field Advisory Committee. JAS is the editor and the Director of the UAB Cochrane Musculoskeletal Group Satellite Center on Network Meta-analysis. JAS served as a member of the American College of Rheumatology’s (ACR) Annual Meeting Planning Committee and Quality of Care Committees, the Chair of the ACR Meet-the-Professor, Workshop and Study Group Subcommittee and the co-chair of the ACR Criteria and Response Criteria subcommittee. JAS is a member of the executive of OMERACT, an organization that develops outcome measures in rheumatology and receives arms-length funding from 36 companies. DCT is the editor-in-chief of The Clinical Journal of Pain and serves as an industry advisor or consultant to AcelRx, GSK/Novartis, and Pfizer. A. Chiarotto, PhD, Postdoctoral Research Fellow, Department of Epidemiology and Biostatistics, VUmc, and Department of General Practice, Erasmus MC, University Medical Center Rotterdam; U. Kaiser, Dr. Rer. Nat., Postdoctoral Research Fellow and Principal Investigator, Comprehensive Pain Center, Medical Faculty of Technical University of Dresden; E. Choy, MD, Professor and Head of Rheumatology, Cardiff University; R. Christensen, PhD, Professor of Biostatistics and Clinical Epidemiology, The Rheumatology Research Unit, Department of Rheumatology, Odense University Hospital and University of Southern Denmark, and Head of Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital; P.G. Conaghan, MB BS, PhD, FRACP, FRCP, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Biomedical Research Centre; M. Cowern, OMERACT Patient Research Partner; M. Gill, BA, Australian National University, and Dragon Claw, and OMERACT Patient Research Partner; M. de Wit, PhD, OMERACT Patient Research Partner, and Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health; E. Gargon, PhD, Research Associate, Department of Biostatistics, University of Liverpool; B. Horgan, OMERACT Patient Research Partner; J.J. Kirkham, PhD, Senior Lecturer in Medical Statistics, Department of Biostatistics, University of Liverpool; L.S. Simon, MD, Principal, SDG LLC; J.A. Singh, MBBS, MPH, Endowed Professor of Medicine, University of Alabama at Birmingham; P. Tugwell, MD, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; D.C. Turk, PhD, John and Emma Bonica Endowed Chair and Professor of Anesthesiology and Pain Research, Department of Anesthesiology and Pain Medicine, University of Washington; P.J. Mease, MD, MACR, Director, Rheumatology Research, Swedish-Providence-St. Joseph Health Systems, and Clinical Professor, University of Washington School of Medicine. Address correspondence to Dr. A. Chiarotto, Department of Epidemiology and Biostatistics, Amsterdam Movement Sciences Research Institute, Amsterdam Public Health Research Institute, Amsterdam UMC (VU University Medical Center), Medical Faculty, F-vleugel, de Boelelaan 1089A, 1081HV Amsterdam, the Netherlands. E-mail: a.chiarotto@vu.nl. Accepted for publication March 8, 2019.
Philip J. Mease
From the Department of Epidemiology and Biostatistics, Amsterdam University Medical Centre (VUmc); VUmc, Department of Medical Humanities, Amsterdam Public Health (APH), Amsterdam; Department of General Practice, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands; Comprehensive Pain Center, University Hospital Carl Gustav Carus Dresden, Medical Faculty of the Technical University Dresden, Dresden, Germany; CREATE Centre, Section of Rheumatology, Division of Infection and Immunity, Cardiff University, Cardiff; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; UK National Institute for Health Research (NIHR) Leeds Biomedical Research Centre, Leeds; Versus Arthritis, Patron Her Royal Highness The Duchess of Cornwall, Chesterfield; MRC North West Hub for Trials Methodology Research, Department of Biostatistics, University of Liverpool, Liverpool, UK; Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen; The Rheumatology Research Unit, Department of Rheumatology, Odense University Hospital; Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark; Dragon Claw (Website for patients with rheumatic disease), New South Wales, Australia; Bingo and Fundraising Promotions, Mal Atwell Leisure Group, Willetton, Australia; SDG LLC, Cambridge, Massachusetts; Medicine Service, VA Medical Center; Departments of Medicine and Epidemiology at the Schools of Medicine and Public Health, University of Alabama at Birmingham, Birmingham, Alabama; Department of Anesthesiology and Pain Medicine, University of Washington; Rheumatology Research Swedish-Providence-St. Joseph Health Systems; University of Washington School of Medicine, Seattle, Washington, USA; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada. AC is supported by a postdoctoral fellowship of the Amsterdam Movement Sciences research institute; he was supported by OMERACT and by a European League Against Rheumatism bursary to attend the OMERACT 2018 conference. UK is funded by a postdoctoral fellowship of the Medical Faculty, Technical University Dresden, and also funded by a federal joint committee of Germany. EC is supported in part by Arthritis Research UK and Health and Care Research Wales through the CREATE Centre. The Parker Institute, Bispebjerg and Frederiksberg Hospital is supported by a core grant from the Oak Foundation (OCAY-13-309). PGC is supported in part by the NIHR Leeds Biomedical Research Centre. The views expressed are those of the author(s) and not necessarily those of the UK National Health Service, the NIHR, or the Department of Health. DCT is supported by the US National Institutes of Health (NIH) and the US Food and Drug Administration. EC has received research grants and/or served as member of advisory boards and speaker bureaus of AbbVie, Allergan, Amgen, AstraZeneca, Bio-Cancer, Biogen, BMS, Boehringer Ingelheim, Celgene, Chugai Pharma, Daiichi Sankyo, Eli Lilly, Ferring Pharmaceutical, GSK, Hospira, ISIS, Jazz Pharmaceuticals, Janssen, MedImmune, Merrimack Pharmaceutical, MSD, Napp, Novimmune, Novartis, ObsEva, Pfizer, Regeneron, Roche, R-Pharm, Sanofi, SynAct Pharma, Synovate, Tonix, and UCB. JAS has received consultant fees from Crealta/Horizon, Fidia, UBM LLC, Medscape, WebMD, the NIH, and the American College of Rheumatology. JAS is a member of the Veterans Affairs Rheumatology Field Advisory Committee. JAS is the editor and the Director of the UAB Cochrane Musculoskeletal Group Satellite Center on Network Meta-analysis. JAS served as a member of the American College of Rheumatology’s (ACR) Annual Meeting Planning Committee and Quality of Care Committees, the Chair of the ACR Meet-the-Professor, Workshop and Study Group Subcommittee and the co-chair of the ACR Criteria and Response Criteria subcommittee. JAS is a member of the executive of OMERACT, an organization that develops outcome measures in rheumatology and receives arms-length funding from 36 companies. DCT is the editor-in-chief of The Clinical Journal of Pain and serves as an industry advisor or consultant to AcelRx, GSK/Novartis, and Pfizer. A. Chiarotto, PhD, Postdoctoral Research Fellow, Department of Epidemiology and Biostatistics, VUmc, and Department of General Practice, Erasmus MC, University Medical Center Rotterdam; U. Kaiser, Dr. Rer. Nat., Postdoctoral Research Fellow and Principal Investigator, Comprehensive Pain Center, Medical Faculty of Technical University of Dresden; E. Choy, MD, Professor and Head of Rheumatology, Cardiff University; R. Christensen, PhD, Professor of Biostatistics and Clinical Epidemiology, The Rheumatology Research Unit, Department of Rheumatology, Odense University Hospital and University of Southern Denmark, and Head of Musculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg Hospital; P.G. Conaghan, MB BS, PhD, FRACP, FRCP, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Biomedical Research Centre; M. Cowern, OMERACT Patient Research Partner; M. Gill, BA, Australian National University, and Dragon Claw, and OMERACT Patient Research Partner; M. de Wit, PhD, OMERACT Patient Research Partner, and Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health; E. Gargon, PhD, Research Associate, Department of Biostatistics, University of Liverpool; B. Horgan, OMERACT Patient Research Partner; J.J. Kirkham, PhD, Senior Lecturer in Medical Statistics, Department of Biostatistics, University of Liverpool; L.S. Simon, MD, Principal, SDG LLC; J.A. Singh, MBBS, MPH, Endowed Professor of Medicine, University of Alabama at Birmingham; P. Tugwell, MD, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; D.C. Turk, PhD, John and Emma Bonica Endowed Chair and Professor of Anesthesiology and Pain Research, Department of Anesthesiology and Pain Medicine, University of Washington; P.J. Mease, MD, MACR, Director, Rheumatology Research, Swedish-Providence-St. Joseph Health Systems, and Clinical Professor, University of Washington School of Medicine. Address correspondence to Dr. A. Chiarotto, Department of Epidemiology and Biostatistics, Amsterdam Movement Sciences Research Institute, Amsterdam Public Health Research Institute, Amsterdam UMC (VU University Medical Center), Medical Faculty, F-vleugel, de Boelelaan 1089A, 1081HV Amsterdam, the Netherlands. E-mail: a.chiarotto@vu.nl. Accepted for publication March 8, 2019.
Abstract
Objective Establishing a research agenda on standardizing pain measurement in clinical trials in rheumatic and musculoskeletal diseases (RMD).
Methods Discussion during a meeting at the Outcome Measures in Rheumatology (OMERACT) 2018, prepared by a systematic review of existing core outcome sets and a patient online survey.
Results Several key questions were debated: Is pain a symptom or a disease? Are pain core (sub)domains consistent across RMD? How to account for pain mechanistic descriptors (e.g., central sensitization) in pain measurement?
Conclusion Characterizing and assessing the spectrum of pain experience across RMD in a standardized fashion is the objective of the OMERACT Pain Working Group.
In this issue
The Journal of Rheumatology
Vol. 51, Issue 3
1 Mar 2024
Pain Measurement in Rheumatic and Musculoskeletal Diseases: Where To Go from Here? Report from a Special Interest Group at OMERACT 2018
Alessandro Chiarotto, Ulrike Kaiser, Ernest Choy, Robin Christensen, Philip G. Conaghan, Mary Cowern, Michael Gill, Maarten de Wit, Elizabeth Gargon, Ben Horgan, Jamie J. Kirkham, Lee S. Simon, Jasvinder A. Singh, Peter Tugwell, Dennis C. Turk, Philip J. Mease
The Journal of Rheumatology Apr 2019, jrheum.181099; DOI: 10.3899/jrheum.181099
Pain Measurement in Rheumatic and Musculoskeletal Diseases: Where To Go from Here? Report from a Special Interest Group at OMERACT 2018
Alessandro Chiarotto, Ulrike Kaiser, Ernest Choy, Robin Christensen, Philip G. Conaghan, Mary Cowern, Michael Gill, Maarten de Wit, Elizabeth Gargon, Ben Horgan, Jamie J. Kirkham, Lee S. Simon, Jasvinder A. Singh, Peter Tugwell, Dennis C. Turk, Philip J. Mease
The Journal of Rheumatology Apr 2019, jrheum.181099; DOI: 10.3899/jrheum.181099