Research ArticleArticle
Update on Outcome Measure Development in Large-vessel Vasculitis: Report from OMERACT 2018
Sibel Z. Aydin, Joanna C. Robson, Antoine G. Sreih, Catherine Hill, Fatma Alibaz-Oner, Sarah Mackie, Susan Beard, Ahmet Gul, Gülen Hatemi, Tanaz A. Kermani, Alfred Mahr, Alexa Meara, Nataliya Milman, Beverley Shea, Gunnar Tómasson, Peter Tugwell, Haner Direskeneli and Peter A. Merkel
The Journal of Rheumatology March 2019, jrheum.181072; DOI: https://doi.org/10.3899/jrheum.181072
Sibel Z. Aydin
From the Division of Rheumatology, University of Ottawa, Ottawa Hospital Research Institute; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Department of Clinical Epidemiology, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; University of the West of England; University of Bristol; University Hospitals Bristol National Health Service (NHS) Trust, Bristol; Leeds Institute of Rheumatic and Musculoskeletal Medicine; Leeds Teaching Hospitals NHS Trust, Leeds, UK; Division of Rheumatology and Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Rheumatology, University of California at Los Angeles, Los Angeles, California; Division of Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Discipline of Medicine, University of Adelaide; The Queen Elizabeth Hospital, Adelaide, Australia; Fatih Sultan Mehmet Training and Research Hospital; Division of Rheumatology, Department of Internal Medicine, Istanbul University, Istanbul Faculty of Medicine; Division of Rheumatology, Department of Internal Medicine, Istanbul University-Cerrahpasa, School of Medicine, Istanbul; Division of Rheumatology, Marmara University, School of Medicine, Marmara, Turkey; Department of Internal Medicine, University Paris Diderot, Paris, France; Department of Public Health Sciences, University of Iceland, Reykjavik, Iceland. This work was funded in part by the US Vasculitis Clinical Research Consortium (VCRC). The VCRC is part of the Rare Diseases Clinical Research Network, an initiative of the Office of Rare Diseases Research, National Center for Advancing Translational Science (NCATS). The VCRC is funded through collaboration between NCATS, and the National Institute of Arthritis and Musculoskeletal and Skin Diseases (U54 AR057319), and has received funding from the National Center for Research Resources (U54 RR019497). S.Z. Aydin, Associate Professor in Rheumatology, Division of Rheumatology, University of Ottawa, Ottawa Hospital Research Institute; J.C. Robson, MRCP, PhD, Consultant Senior Lecturer, University of the West of England, and Honorary Senior Lecturer, University of Bristol, and Honorary Consultant in Rheumatology, University Hospitals Bristol NHS Trust; A.G. Sreih, MD, Assistant Professor of Medicine, Division of Rheumatology, University of Pennsylvania; C. Hill, MD, Professor, Discipline of Medicine, University of Adelaide, and Consultant Rheumatologist, The Queen Elizabeth Hospital; F. Alibaz-Oner, MD, Associate Professor of Rheumatology, Fatih Sultan Mehmet Training and Research Hospital; S. Mackie, MRCP, PhD, Associate Professor, Leeds Institute of Rheumatic and Musculoskeletal Medicine, and Honorary Consultant Rheumatologist, Leeds Teaching Hospitals NHS Trust; S. Beard, Bmus, Adelaide, Australia; A. Gul, MD, Professor of Rheumatology, Division of Rheumatology, Department of Internal Medicine, Istanbul University, Istanbul Faculty of Medicine; G. Hatemi, MD, Professor of Medicine, Division of Rheumatology, Department of Internal Medicine, Istanbul University-Cerrahpasa, School of Medicine; T.A. Kermani, MD, MS, Associate Professor of Medicine, Division of Rheumatology, University of California at Los Angeles; A. Mahr, MD, PhD, Professor of Internal Medicine, Department of Internal Medicine, University Paris Diderot; A. Meara, MD, Assistant Professor, Division of Rheumatology and Immunology, The Ohio State University Wexner Medical Center; N. Milman, MD, Assistant Professor, Division of Rheumatology, University of Ottawa, and Division of Rheumatology, The Ottawa Hospital, and Department of Clinical Epidemiology, Ottawa Hospital Research Institute; B. Shea, PhD, Clinical Investigator and Adjunct Professor, Ottawa Hospital Research Institute, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; G. Tómasson, MD, PhD, Assistant Professor of Medicine, Department of Public Health Sciences, University of Iceland; P. Tugwell, MD, Professor, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; H. Direskeneli, MD, Professor of Medicine, Division of Rheumatology, Marmara University, School of Medicine; P.A. Merkel, MD, MPH, Professor of Medicine and Epidemiology, Division of Rheumatology and Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania. Address correspondence to Dr. P.A. Merkel, Chief, Division of Rheumatology, Professor of Medicine and Epidemiology, University of Pennsylvania, White Building, 5th Floor, 3400 Spruce St., Philadelphia, Pennsylvania 19104, USA. E-mail: pmerkel@upenn.edu. Accepted for publication February 20, 2019.
Joanna C. Robson
From the Division of Rheumatology, University of Ottawa, Ottawa Hospital Research Institute; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Department of Clinical Epidemiology, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; University of the West of England; University of Bristol; University Hospitals Bristol National Health Service (NHS) Trust, Bristol; Leeds Institute of Rheumatic and Musculoskeletal Medicine; Leeds Teaching Hospitals NHS Trust, Leeds, UK; Division of Rheumatology and Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Rheumatology, University of California at Los Angeles, Los Angeles, California; Division of Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Discipline of Medicine, University of Adelaide; The Queen Elizabeth Hospital, Adelaide, Australia; Fatih Sultan Mehmet Training and Research Hospital; Division of Rheumatology, Department of Internal Medicine, Istanbul University, Istanbul Faculty of Medicine; Division of Rheumatology, Department of Internal Medicine, Istanbul University-Cerrahpasa, School of Medicine, Istanbul; Division of Rheumatology, Marmara University, School of Medicine, Marmara, Turkey; Department of Internal Medicine, University Paris Diderot, Paris, France; Department of Public Health Sciences, University of Iceland, Reykjavik, Iceland. This work was funded in part by the US Vasculitis Clinical Research Consortium (VCRC). The VCRC is part of the Rare Diseases Clinical Research Network, an initiative of the Office of Rare Diseases Research, National Center for Advancing Translational Science (NCATS). The VCRC is funded through collaboration between NCATS, and the National Institute of Arthritis and Musculoskeletal and Skin Diseases (U54 AR057319), and has received funding from the National Center for Research Resources (U54 RR019497). S.Z. Aydin, Associate Professor in Rheumatology, Division of Rheumatology, University of Ottawa, Ottawa Hospital Research Institute; J.C. Robson, MRCP, PhD, Consultant Senior Lecturer, University of the West of England, and Honorary Senior Lecturer, University of Bristol, and Honorary Consultant in Rheumatology, University Hospitals Bristol NHS Trust; A.G. Sreih, MD, Assistant Professor of Medicine, Division of Rheumatology, University of Pennsylvania; C. Hill, MD, Professor, Discipline of Medicine, University of Adelaide, and Consultant Rheumatologist, The Queen Elizabeth Hospital; F. Alibaz-Oner, MD, Associate Professor of Rheumatology, Fatih Sultan Mehmet Training and Research Hospital; S. Mackie, MRCP, PhD, Associate Professor, Leeds Institute of Rheumatic and Musculoskeletal Medicine, and Honorary Consultant Rheumatologist, Leeds Teaching Hospitals NHS Trust; S. Beard, Bmus, Adelaide, Australia; A. Gul, MD, Professor of Rheumatology, Division of Rheumatology, Department of Internal Medicine, Istanbul University, Istanbul Faculty of Medicine; G. Hatemi, MD, Professor of Medicine, Division of Rheumatology, Department of Internal Medicine, Istanbul University-Cerrahpasa, School of Medicine; T.A. Kermani, MD, MS, Associate Professor of Medicine, Division of Rheumatology, University of California at Los Angeles; A. Mahr, MD, PhD, Professor of Internal Medicine, Department of Internal Medicine, University Paris Diderot; A. Meara, MD, Assistant Professor, Division of Rheumatology and Immunology, The Ohio State University Wexner Medical Center; N. Milman, MD, Assistant Professor, Division of Rheumatology, University of Ottawa, and Division of Rheumatology, The Ottawa Hospital, and Department of Clinical Epidemiology, Ottawa Hospital Research Institute; B. Shea, PhD, Clinical Investigator and Adjunct Professor, Ottawa Hospital Research Institute, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; G. Tómasson, MD, PhD, Assistant Professor of Medicine, Department of Public Health Sciences, University of Iceland; P. Tugwell, MD, Professor, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; H. Direskeneli, MD, Professor of Medicine, Division of Rheumatology, Marmara University, School of Medicine; P.A. Merkel, MD, MPH, Professor of Medicine and Epidemiology, Division of Rheumatology and Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania. Address correspondence to Dr. P.A. Merkel, Chief, Division of Rheumatology, Professor of Medicine and Epidemiology, University of Pennsylvania, White Building, 5th Floor, 3400 Spruce St., Philadelphia, Pennsylvania 19104, USA. E-mail: pmerkel@upenn.edu. Accepted for publication February 20, 2019.
Antoine G. Sreih
From the Division of Rheumatology, University of Ottawa, Ottawa Hospital Research Institute; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Department of Clinical Epidemiology, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; University of the West of England; University of Bristol; University Hospitals Bristol National Health Service (NHS) Trust, Bristol; Leeds Institute of Rheumatic and Musculoskeletal Medicine; Leeds Teaching Hospitals NHS Trust, Leeds, UK; Division of Rheumatology and Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Rheumatology, University of California at Los Angeles, Los Angeles, California; Division of Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Discipline of Medicine, University of Adelaide; The Queen Elizabeth Hospital, Adelaide, Australia; Fatih Sultan Mehmet Training and Research Hospital; Division of Rheumatology, Department of Internal Medicine, Istanbul University, Istanbul Faculty of Medicine; Division of Rheumatology, Department of Internal Medicine, Istanbul University-Cerrahpasa, School of Medicine, Istanbul; Division of Rheumatology, Marmara University, School of Medicine, Marmara, Turkey; Department of Internal Medicine, University Paris Diderot, Paris, France; Department of Public Health Sciences, University of Iceland, Reykjavik, Iceland. This work was funded in part by the US Vasculitis Clinical Research Consortium (VCRC). The VCRC is part of the Rare Diseases Clinical Research Network, an initiative of the Office of Rare Diseases Research, National Center for Advancing Translational Science (NCATS). The VCRC is funded through collaboration between NCATS, and the National Institute of Arthritis and Musculoskeletal and Skin Diseases (U54 AR057319), and has received funding from the National Center for Research Resources (U54 RR019497). S.Z. Aydin, Associate Professor in Rheumatology, Division of Rheumatology, University of Ottawa, Ottawa Hospital Research Institute; J.C. Robson, MRCP, PhD, Consultant Senior Lecturer, University of the West of England, and Honorary Senior Lecturer, University of Bristol, and Honorary Consultant in Rheumatology, University Hospitals Bristol NHS Trust; A.G. Sreih, MD, Assistant Professor of Medicine, Division of Rheumatology, University of Pennsylvania; C. Hill, MD, Professor, Discipline of Medicine, University of Adelaide, and Consultant Rheumatologist, The Queen Elizabeth Hospital; F. Alibaz-Oner, MD, Associate Professor of Rheumatology, Fatih Sultan Mehmet Training and Research Hospital; S. Mackie, MRCP, PhD, Associate Professor, Leeds Institute of Rheumatic and Musculoskeletal Medicine, and Honorary Consultant Rheumatologist, Leeds Teaching Hospitals NHS Trust; S. Beard, Bmus, Adelaide, Australia; A. Gul, MD, Professor of Rheumatology, Division of Rheumatology, Department of Internal Medicine, Istanbul University, Istanbul Faculty of Medicine; G. Hatemi, MD, Professor of Medicine, Division of Rheumatology, Department of Internal Medicine, Istanbul University-Cerrahpasa, School of Medicine; T.A. Kermani, MD, MS, Associate Professor of Medicine, Division of Rheumatology, University of California at Los Angeles; A. Mahr, MD, PhD, Professor of Internal Medicine, Department of Internal Medicine, University Paris Diderot; A. Meara, MD, Assistant Professor, Division of Rheumatology and Immunology, The Ohio State University Wexner Medical Center; N. Milman, MD, Assistant Professor, Division of Rheumatology, University of Ottawa, and Division of Rheumatology, The Ottawa Hospital, and Department of Clinical Epidemiology, Ottawa Hospital Research Institute; B. Shea, PhD, Clinical Investigator and Adjunct Professor, Ottawa Hospital Research Institute, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; G. Tómasson, MD, PhD, Assistant Professor of Medicine, Department of Public Health Sciences, University of Iceland; P. Tugwell, MD, Professor, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; H. Direskeneli, MD, Professor of Medicine, Division of Rheumatology, Marmara University, School of Medicine; P.A. Merkel, MD, MPH, Professor of Medicine and Epidemiology, Division of Rheumatology and Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania. Address correspondence to Dr. P.A. Merkel, Chief, Division of Rheumatology, Professor of Medicine and Epidemiology, University of Pennsylvania, White Building, 5th Floor, 3400 Spruce St., Philadelphia, Pennsylvania 19104, USA. E-mail: pmerkel@upenn.edu. Accepted for publication February 20, 2019.
Catherine Hill
From the Division of Rheumatology, University of Ottawa, Ottawa Hospital Research Institute; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Department of Clinical Epidemiology, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; University of the West of England; University of Bristol; University Hospitals Bristol National Health Service (NHS) Trust, Bristol; Leeds Institute of Rheumatic and Musculoskeletal Medicine; Leeds Teaching Hospitals NHS Trust, Leeds, UK; Division of Rheumatology and Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Rheumatology, University of California at Los Angeles, Los Angeles, California; Division of Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Discipline of Medicine, University of Adelaide; The Queen Elizabeth Hospital, Adelaide, Australia; Fatih Sultan Mehmet Training and Research Hospital; Division of Rheumatology, Department of Internal Medicine, Istanbul University, Istanbul Faculty of Medicine; Division of Rheumatology, Department of Internal Medicine, Istanbul University-Cerrahpasa, School of Medicine, Istanbul; Division of Rheumatology, Marmara University, School of Medicine, Marmara, Turkey; Department of Internal Medicine, University Paris Diderot, Paris, France; Department of Public Health Sciences, University of Iceland, Reykjavik, Iceland. This work was funded in part by the US Vasculitis Clinical Research Consortium (VCRC). The VCRC is part of the Rare Diseases Clinical Research Network, an initiative of the Office of Rare Diseases Research, National Center for Advancing Translational Science (NCATS). The VCRC is funded through collaboration between NCATS, and the National Institute of Arthritis and Musculoskeletal and Skin Diseases (U54 AR057319), and has received funding from the National Center for Research Resources (U54 RR019497). S.Z. Aydin, Associate Professor in Rheumatology, Division of Rheumatology, University of Ottawa, Ottawa Hospital Research Institute; J.C. Robson, MRCP, PhD, Consultant Senior Lecturer, University of the West of England, and Honorary Senior Lecturer, University of Bristol, and Honorary Consultant in Rheumatology, University Hospitals Bristol NHS Trust; A.G. Sreih, MD, Assistant Professor of Medicine, Division of Rheumatology, University of Pennsylvania; C. Hill, MD, Professor, Discipline of Medicine, University of Adelaide, and Consultant Rheumatologist, The Queen Elizabeth Hospital; F. Alibaz-Oner, MD, Associate Professor of Rheumatology, Fatih Sultan Mehmet Training and Research Hospital; S. Mackie, MRCP, PhD, Associate Professor, Leeds Institute of Rheumatic and Musculoskeletal Medicine, and Honorary Consultant Rheumatologist, Leeds Teaching Hospitals NHS Trust; S. Beard, Bmus, Adelaide, Australia; A. Gul, MD, Professor of Rheumatology, Division of Rheumatology, Department of Internal Medicine, Istanbul University, Istanbul Faculty of Medicine; G. Hatemi, MD, Professor of Medicine, Division of Rheumatology, Department of Internal Medicine, Istanbul University-Cerrahpasa, School of Medicine; T.A. Kermani, MD, MS, Associate Professor of Medicine, Division of Rheumatology, University of California at Los Angeles; A. Mahr, MD, PhD, Professor of Internal Medicine, Department of Internal Medicine, University Paris Diderot; A. Meara, MD, Assistant Professor, Division of Rheumatology and Immunology, The Ohio State University Wexner Medical Center; N. Milman, MD, Assistant Professor, Division of Rheumatology, University of Ottawa, and Division of Rheumatology, The Ottawa Hospital, and Department of Clinical Epidemiology, Ottawa Hospital Research Institute; B. Shea, PhD, Clinical Investigator and Adjunct Professor, Ottawa Hospital Research Institute, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; G. Tómasson, MD, PhD, Assistant Professor of Medicine, Department of Public Health Sciences, University of Iceland; P. Tugwell, MD, Professor, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; H. Direskeneli, MD, Professor of Medicine, Division of Rheumatology, Marmara University, School of Medicine; P.A. Merkel, MD, MPH, Professor of Medicine and Epidemiology, Division of Rheumatology and Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania. Address correspondence to Dr. P.A. Merkel, Chief, Division of Rheumatology, Professor of Medicine and Epidemiology, University of Pennsylvania, White Building, 5th Floor, 3400 Spruce St., Philadelphia, Pennsylvania 19104, USA. E-mail: pmerkel@upenn.edu. Accepted for publication February 20, 2019.
Fatma Alibaz-Oner
From the Division of Rheumatology, University of Ottawa, Ottawa Hospital Research Institute; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Department of Clinical Epidemiology, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; University of the West of England; University of Bristol; University Hospitals Bristol National Health Service (NHS) Trust, Bristol; Leeds Institute of Rheumatic and Musculoskeletal Medicine; Leeds Teaching Hospitals NHS Trust, Leeds, UK; Division of Rheumatology and Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Rheumatology, University of California at Los Angeles, Los Angeles, California; Division of Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Discipline of Medicine, University of Adelaide; The Queen Elizabeth Hospital, Adelaide, Australia; Fatih Sultan Mehmet Training and Research Hospital; Division of Rheumatology, Department of Internal Medicine, Istanbul University, Istanbul Faculty of Medicine; Division of Rheumatology, Department of Internal Medicine, Istanbul University-Cerrahpasa, School of Medicine, Istanbul; Division of Rheumatology, Marmara University, School of Medicine, Marmara, Turkey; Department of Internal Medicine, University Paris Diderot, Paris, France; Department of Public Health Sciences, University of Iceland, Reykjavik, Iceland. This work was funded in part by the US Vasculitis Clinical Research Consortium (VCRC). The VCRC is part of the Rare Diseases Clinical Research Network, an initiative of the Office of Rare Diseases Research, National Center for Advancing Translational Science (NCATS). The VCRC is funded through collaboration between NCATS, and the National Institute of Arthritis and Musculoskeletal and Skin Diseases (U54 AR057319), and has received funding from the National Center for Research Resources (U54 RR019497). S.Z. Aydin, Associate Professor in Rheumatology, Division of Rheumatology, University of Ottawa, Ottawa Hospital Research Institute; J.C. Robson, MRCP, PhD, Consultant Senior Lecturer, University of the West of England, and Honorary Senior Lecturer, University of Bristol, and Honorary Consultant in Rheumatology, University Hospitals Bristol NHS Trust; A.G. Sreih, MD, Assistant Professor of Medicine, Division of Rheumatology, University of Pennsylvania; C. Hill, MD, Professor, Discipline of Medicine, University of Adelaide, and Consultant Rheumatologist, The Queen Elizabeth Hospital; F. Alibaz-Oner, MD, Associate Professor of Rheumatology, Fatih Sultan Mehmet Training and Research Hospital; S. Mackie, MRCP, PhD, Associate Professor, Leeds Institute of Rheumatic and Musculoskeletal Medicine, and Honorary Consultant Rheumatologist, Leeds Teaching Hospitals NHS Trust; S. Beard, Bmus, Adelaide, Australia; A. Gul, MD, Professor of Rheumatology, Division of Rheumatology, Department of Internal Medicine, Istanbul University, Istanbul Faculty of Medicine; G. Hatemi, MD, Professor of Medicine, Division of Rheumatology, Department of Internal Medicine, Istanbul University-Cerrahpasa, School of Medicine; T.A. Kermani, MD, MS, Associate Professor of Medicine, Division of Rheumatology, University of California at Los Angeles; A. Mahr, MD, PhD, Professor of Internal Medicine, Department of Internal Medicine, University Paris Diderot; A. Meara, MD, Assistant Professor, Division of Rheumatology and Immunology, The Ohio State University Wexner Medical Center; N. Milman, MD, Assistant Professor, Division of Rheumatology, University of Ottawa, and Division of Rheumatology, The Ottawa Hospital, and Department of Clinical Epidemiology, Ottawa Hospital Research Institute; B. Shea, PhD, Clinical Investigator and Adjunct Professor, Ottawa Hospital Research Institute, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; G. Tómasson, MD, PhD, Assistant Professor of Medicine, Department of Public Health Sciences, University of Iceland; P. Tugwell, MD, Professor, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; H. Direskeneli, MD, Professor of Medicine, Division of Rheumatology, Marmara University, School of Medicine; P.A. Merkel, MD, MPH, Professor of Medicine and Epidemiology, Division of Rheumatology and Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania. Address correspondence to Dr. P.A. Merkel, Chief, Division of Rheumatology, Professor of Medicine and Epidemiology, University of Pennsylvania, White Building, 5th Floor, 3400 Spruce St., Philadelphia, Pennsylvania 19104, USA. E-mail: pmerkel@upenn.edu. Accepted for publication February 20, 2019.
Sarah Mackie
From the Division of Rheumatology, University of Ottawa, Ottawa Hospital Research Institute; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Department of Clinical Epidemiology, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; University of the West of England; University of Bristol; University Hospitals Bristol National Health Service (NHS) Trust, Bristol; Leeds Institute of Rheumatic and Musculoskeletal Medicine; Leeds Teaching Hospitals NHS Trust, Leeds, UK; Division of Rheumatology and Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Rheumatology, University of California at Los Angeles, Los Angeles, California; Division of Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Discipline of Medicine, University of Adelaide; The Queen Elizabeth Hospital, Adelaide, Australia; Fatih Sultan Mehmet Training and Research Hospital; Division of Rheumatology, Department of Internal Medicine, Istanbul University, Istanbul Faculty of Medicine; Division of Rheumatology, Department of Internal Medicine, Istanbul University-Cerrahpasa, School of Medicine, Istanbul; Division of Rheumatology, Marmara University, School of Medicine, Marmara, Turkey; Department of Internal Medicine, University Paris Diderot, Paris, France; Department of Public Health Sciences, University of Iceland, Reykjavik, Iceland. This work was funded in part by the US Vasculitis Clinical Research Consortium (VCRC). The VCRC is part of the Rare Diseases Clinical Research Network, an initiative of the Office of Rare Diseases Research, National Center for Advancing Translational Science (NCATS). The VCRC is funded through collaboration between NCATS, and the National Institute of Arthritis and Musculoskeletal and Skin Diseases (U54 AR057319), and has received funding from the National Center for Research Resources (U54 RR019497). S.Z. Aydin, Associate Professor in Rheumatology, Division of Rheumatology, University of Ottawa, Ottawa Hospital Research Institute; J.C. Robson, MRCP, PhD, Consultant Senior Lecturer, University of the West of England, and Honorary Senior Lecturer, University of Bristol, and Honorary Consultant in Rheumatology, University Hospitals Bristol NHS Trust; A.G. Sreih, MD, Assistant Professor of Medicine, Division of Rheumatology, University of Pennsylvania; C. Hill, MD, Professor, Discipline of Medicine, University of Adelaide, and Consultant Rheumatologist, The Queen Elizabeth Hospital; F. Alibaz-Oner, MD, Associate Professor of Rheumatology, Fatih Sultan Mehmet Training and Research Hospital; S. Mackie, MRCP, PhD, Associate Professor, Leeds Institute of Rheumatic and Musculoskeletal Medicine, and Honorary Consultant Rheumatologist, Leeds Teaching Hospitals NHS Trust; S. Beard, Bmus, Adelaide, Australia; A. Gul, MD, Professor of Rheumatology, Division of Rheumatology, Department of Internal Medicine, Istanbul University, Istanbul Faculty of Medicine; G. Hatemi, MD, Professor of Medicine, Division of Rheumatology, Department of Internal Medicine, Istanbul University-Cerrahpasa, School of Medicine; T.A. Kermani, MD, MS, Associate Professor of Medicine, Division of Rheumatology, University of California at Los Angeles; A. Mahr, MD, PhD, Professor of Internal Medicine, Department of Internal Medicine, University Paris Diderot; A. Meara, MD, Assistant Professor, Division of Rheumatology and Immunology, The Ohio State University Wexner Medical Center; N. Milman, MD, Assistant Professor, Division of Rheumatology, University of Ottawa, and Division of Rheumatology, The Ottawa Hospital, and Department of Clinical Epidemiology, Ottawa Hospital Research Institute; B. Shea, PhD, Clinical Investigator and Adjunct Professor, Ottawa Hospital Research Institute, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; G. Tómasson, MD, PhD, Assistant Professor of Medicine, Department of Public Health Sciences, University of Iceland; P. Tugwell, MD, Professor, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; H. Direskeneli, MD, Professor of Medicine, Division of Rheumatology, Marmara University, School of Medicine; P.A. Merkel, MD, MPH, Professor of Medicine and Epidemiology, Division of Rheumatology and Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania. Address correspondence to Dr. P.A. Merkel, Chief, Division of Rheumatology, Professor of Medicine and Epidemiology, University of Pennsylvania, White Building, 5th Floor, 3400 Spruce St., Philadelphia, Pennsylvania 19104, USA. E-mail: pmerkel@upenn.edu. Accepted for publication February 20, 2019.
Susan Beard
From the Division of Rheumatology, University of Ottawa, Ottawa Hospital Research Institute; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Department of Clinical Epidemiology, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; University of the West of England; University of Bristol; University Hospitals Bristol National Health Service (NHS) Trust, Bristol; Leeds Institute of Rheumatic and Musculoskeletal Medicine; Leeds Teaching Hospitals NHS Trust, Leeds, UK; Division of Rheumatology and Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Rheumatology, University of California at Los Angeles, Los Angeles, California; Division of Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Discipline of Medicine, University of Adelaide; The Queen Elizabeth Hospital, Adelaide, Australia; Fatih Sultan Mehmet Training and Research Hospital; Division of Rheumatology, Department of Internal Medicine, Istanbul University, Istanbul Faculty of Medicine; Division of Rheumatology, Department of Internal Medicine, Istanbul University-Cerrahpasa, School of Medicine, Istanbul; Division of Rheumatology, Marmara University, School of Medicine, Marmara, Turkey; Department of Internal Medicine, University Paris Diderot, Paris, France; Department of Public Health Sciences, University of Iceland, Reykjavik, Iceland. This work was funded in part by the US Vasculitis Clinical Research Consortium (VCRC). The VCRC is part of the Rare Diseases Clinical Research Network, an initiative of the Office of Rare Diseases Research, National Center for Advancing Translational Science (NCATS). The VCRC is funded through collaboration between NCATS, and the National Institute of Arthritis and Musculoskeletal and Skin Diseases (U54 AR057319), and has received funding from the National Center for Research Resources (U54 RR019497). S.Z. Aydin, Associate Professor in Rheumatology, Division of Rheumatology, University of Ottawa, Ottawa Hospital Research Institute; J.C. Robson, MRCP, PhD, Consultant Senior Lecturer, University of the West of England, and Honorary Senior Lecturer, University of Bristol, and Honorary Consultant in Rheumatology, University Hospitals Bristol NHS Trust; A.G. Sreih, MD, Assistant Professor of Medicine, Division of Rheumatology, University of Pennsylvania; C. Hill, MD, Professor, Discipline of Medicine, University of Adelaide, and Consultant Rheumatologist, The Queen Elizabeth Hospital; F. Alibaz-Oner, MD, Associate Professor of Rheumatology, Fatih Sultan Mehmet Training and Research Hospital; S. Mackie, MRCP, PhD, Associate Professor, Leeds Institute of Rheumatic and Musculoskeletal Medicine, and Honorary Consultant Rheumatologist, Leeds Teaching Hospitals NHS Trust; S. Beard, Bmus, Adelaide, Australia; A. Gul, MD, Professor of Rheumatology, Division of Rheumatology, Department of Internal Medicine, Istanbul University, Istanbul Faculty of Medicine; G. Hatemi, MD, Professor of Medicine, Division of Rheumatology, Department of Internal Medicine, Istanbul University-Cerrahpasa, School of Medicine; T.A. Kermani, MD, MS, Associate Professor of Medicine, Division of Rheumatology, University of California at Los Angeles; A. Mahr, MD, PhD, Professor of Internal Medicine, Department of Internal Medicine, University Paris Diderot; A. Meara, MD, Assistant Professor, Division of Rheumatology and Immunology, The Ohio State University Wexner Medical Center; N. Milman, MD, Assistant Professor, Division of Rheumatology, University of Ottawa, and Division of Rheumatology, The Ottawa Hospital, and Department of Clinical Epidemiology, Ottawa Hospital Research Institute; B. Shea, PhD, Clinical Investigator and Adjunct Professor, Ottawa Hospital Research Institute, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; G. Tómasson, MD, PhD, Assistant Professor of Medicine, Department of Public Health Sciences, University of Iceland; P. Tugwell, MD, Professor, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; H. Direskeneli, MD, Professor of Medicine, Division of Rheumatology, Marmara University, School of Medicine; P.A. Merkel, MD, MPH, Professor of Medicine and Epidemiology, Division of Rheumatology and Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania. Address correspondence to Dr. P.A. Merkel, Chief, Division of Rheumatology, Professor of Medicine and Epidemiology, University of Pennsylvania, White Building, 5th Floor, 3400 Spruce St., Philadelphia, Pennsylvania 19104, USA. E-mail: pmerkel@upenn.edu. Accepted for publication February 20, 2019.
Ahmet Gul
From the Division of Rheumatology, University of Ottawa, Ottawa Hospital Research Institute; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Department of Clinical Epidemiology, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; University of the West of England; University of Bristol; University Hospitals Bristol National Health Service (NHS) Trust, Bristol; Leeds Institute of Rheumatic and Musculoskeletal Medicine; Leeds Teaching Hospitals NHS Trust, Leeds, UK; Division of Rheumatology and Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Rheumatology, University of California at Los Angeles, Los Angeles, California; Division of Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Discipline of Medicine, University of Adelaide; The Queen Elizabeth Hospital, Adelaide, Australia; Fatih Sultan Mehmet Training and Research Hospital; Division of Rheumatology, Department of Internal Medicine, Istanbul University, Istanbul Faculty of Medicine; Division of Rheumatology, Department of Internal Medicine, Istanbul University-Cerrahpasa, School of Medicine, Istanbul; Division of Rheumatology, Marmara University, School of Medicine, Marmara, Turkey; Department of Internal Medicine, University Paris Diderot, Paris, France; Department of Public Health Sciences, University of Iceland, Reykjavik, Iceland. This work was funded in part by the US Vasculitis Clinical Research Consortium (VCRC). The VCRC is part of the Rare Diseases Clinical Research Network, an initiative of the Office of Rare Diseases Research, National Center for Advancing Translational Science (NCATS). The VCRC is funded through collaboration between NCATS, and the National Institute of Arthritis and Musculoskeletal and Skin Diseases (U54 AR057319), and has received funding from the National Center for Research Resources (U54 RR019497). S.Z. Aydin, Associate Professor in Rheumatology, Division of Rheumatology, University of Ottawa, Ottawa Hospital Research Institute; J.C. Robson, MRCP, PhD, Consultant Senior Lecturer, University of the West of England, and Honorary Senior Lecturer, University of Bristol, and Honorary Consultant in Rheumatology, University Hospitals Bristol NHS Trust; A.G. Sreih, MD, Assistant Professor of Medicine, Division of Rheumatology, University of Pennsylvania; C. Hill, MD, Professor, Discipline of Medicine, University of Adelaide, and Consultant Rheumatologist, The Queen Elizabeth Hospital; F. Alibaz-Oner, MD, Associate Professor of Rheumatology, Fatih Sultan Mehmet Training and Research Hospital; S. Mackie, MRCP, PhD, Associate Professor, Leeds Institute of Rheumatic and Musculoskeletal Medicine, and Honorary Consultant Rheumatologist, Leeds Teaching Hospitals NHS Trust; S. Beard, Bmus, Adelaide, Australia; A. Gul, MD, Professor of Rheumatology, Division of Rheumatology, Department of Internal Medicine, Istanbul University, Istanbul Faculty of Medicine; G. Hatemi, MD, Professor of Medicine, Division of Rheumatology, Department of Internal Medicine, Istanbul University-Cerrahpasa, School of Medicine; T.A. Kermani, MD, MS, Associate Professor of Medicine, Division of Rheumatology, University of California at Los Angeles; A. Mahr, MD, PhD, Professor of Internal Medicine, Department of Internal Medicine, University Paris Diderot; A. Meara, MD, Assistant Professor, Division of Rheumatology and Immunology, The Ohio State University Wexner Medical Center; N. Milman, MD, Assistant Professor, Division of Rheumatology, University of Ottawa, and Division of Rheumatology, The Ottawa Hospital, and Department of Clinical Epidemiology, Ottawa Hospital Research Institute; B. Shea, PhD, Clinical Investigator and Adjunct Professor, Ottawa Hospital Research Institute, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; G. Tómasson, MD, PhD, Assistant Professor of Medicine, Department of Public Health Sciences, University of Iceland; P. Tugwell, MD, Professor, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; H. Direskeneli, MD, Professor of Medicine, Division of Rheumatology, Marmara University, School of Medicine; P.A. Merkel, MD, MPH, Professor of Medicine and Epidemiology, Division of Rheumatology and Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania. Address correspondence to Dr. P.A. Merkel, Chief, Division of Rheumatology, Professor of Medicine and Epidemiology, University of Pennsylvania, White Building, 5th Floor, 3400 Spruce St., Philadelphia, Pennsylvania 19104, USA. E-mail: pmerkel@upenn.edu. Accepted for publication February 20, 2019.
Gülen Hatemi
From the Division of Rheumatology, University of Ottawa, Ottawa Hospital Research Institute; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Department of Clinical Epidemiology, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; University of the West of England; University of Bristol; University Hospitals Bristol National Health Service (NHS) Trust, Bristol; Leeds Institute of Rheumatic and Musculoskeletal Medicine; Leeds Teaching Hospitals NHS Trust, Leeds, UK; Division of Rheumatology and Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Rheumatology, University of California at Los Angeles, Los Angeles, California; Division of Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Discipline of Medicine, University of Adelaide; The Queen Elizabeth Hospital, Adelaide, Australia; Fatih Sultan Mehmet Training and Research Hospital; Division of Rheumatology, Department of Internal Medicine, Istanbul University, Istanbul Faculty of Medicine; Division of Rheumatology, Department of Internal Medicine, Istanbul University-Cerrahpasa, School of Medicine, Istanbul; Division of Rheumatology, Marmara University, School of Medicine, Marmara, Turkey; Department of Internal Medicine, University Paris Diderot, Paris, France; Department of Public Health Sciences, University of Iceland, Reykjavik, Iceland. This work was funded in part by the US Vasculitis Clinical Research Consortium (VCRC). The VCRC is part of the Rare Diseases Clinical Research Network, an initiative of the Office of Rare Diseases Research, National Center for Advancing Translational Science (NCATS). The VCRC is funded through collaboration between NCATS, and the National Institute of Arthritis and Musculoskeletal and Skin Diseases (U54 AR057319), and has received funding from the National Center for Research Resources (U54 RR019497). S.Z. Aydin, Associate Professor in Rheumatology, Division of Rheumatology, University of Ottawa, Ottawa Hospital Research Institute; J.C. Robson, MRCP, PhD, Consultant Senior Lecturer, University of the West of England, and Honorary Senior Lecturer, University of Bristol, and Honorary Consultant in Rheumatology, University Hospitals Bristol NHS Trust; A.G. Sreih, MD, Assistant Professor of Medicine, Division of Rheumatology, University of Pennsylvania; C. Hill, MD, Professor, Discipline of Medicine, University of Adelaide, and Consultant Rheumatologist, The Queen Elizabeth Hospital; F. Alibaz-Oner, MD, Associate Professor of Rheumatology, Fatih Sultan Mehmet Training and Research Hospital; S. Mackie, MRCP, PhD, Associate Professor, Leeds Institute of Rheumatic and Musculoskeletal Medicine, and Honorary Consultant Rheumatologist, Leeds Teaching Hospitals NHS Trust; S. Beard, Bmus, Adelaide, Australia; A. Gul, MD, Professor of Rheumatology, Division of Rheumatology, Department of Internal Medicine, Istanbul University, Istanbul Faculty of Medicine; G. Hatemi, MD, Professor of Medicine, Division of Rheumatology, Department of Internal Medicine, Istanbul University-Cerrahpasa, School of Medicine; T.A. Kermani, MD, MS, Associate Professor of Medicine, Division of Rheumatology, University of California at Los Angeles; A. Mahr, MD, PhD, Professor of Internal Medicine, Department of Internal Medicine, University Paris Diderot; A. Meara, MD, Assistant Professor, Division of Rheumatology and Immunology, The Ohio State University Wexner Medical Center; N. Milman, MD, Assistant Professor, Division of Rheumatology, University of Ottawa, and Division of Rheumatology, The Ottawa Hospital, and Department of Clinical Epidemiology, Ottawa Hospital Research Institute; B. Shea, PhD, Clinical Investigator and Adjunct Professor, Ottawa Hospital Research Institute, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; G. Tómasson, MD, PhD, Assistant Professor of Medicine, Department of Public Health Sciences, University of Iceland; P. Tugwell, MD, Professor, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; H. Direskeneli, MD, Professor of Medicine, Division of Rheumatology, Marmara University, School of Medicine; P.A. Merkel, MD, MPH, Professor of Medicine and Epidemiology, Division of Rheumatology and Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania. Address correspondence to Dr. P.A. Merkel, Chief, Division of Rheumatology, Professor of Medicine and Epidemiology, University of Pennsylvania, White Building, 5th Floor, 3400 Spruce St., Philadelphia, Pennsylvania 19104, USA. E-mail: pmerkel@upenn.edu. Accepted for publication February 20, 2019.
Tanaz A. Kermani
From the Division of Rheumatology, University of Ottawa, Ottawa Hospital Research Institute; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Department of Clinical Epidemiology, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; University of the West of England; University of Bristol; University Hospitals Bristol National Health Service (NHS) Trust, Bristol; Leeds Institute of Rheumatic and Musculoskeletal Medicine; Leeds Teaching Hospitals NHS Trust, Leeds, UK; Division of Rheumatology and Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Rheumatology, University of California at Los Angeles, Los Angeles, California; Division of Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Discipline of Medicine, University of Adelaide; The Queen Elizabeth Hospital, Adelaide, Australia; Fatih Sultan Mehmet Training and Research Hospital; Division of Rheumatology, Department of Internal Medicine, Istanbul University, Istanbul Faculty of Medicine; Division of Rheumatology, Department of Internal Medicine, Istanbul University-Cerrahpasa, School of Medicine, Istanbul; Division of Rheumatology, Marmara University, School of Medicine, Marmara, Turkey; Department of Internal Medicine, University Paris Diderot, Paris, France; Department of Public Health Sciences, University of Iceland, Reykjavik, Iceland. This work was funded in part by the US Vasculitis Clinical Research Consortium (VCRC). The VCRC is part of the Rare Diseases Clinical Research Network, an initiative of the Office of Rare Diseases Research, National Center for Advancing Translational Science (NCATS). The VCRC is funded through collaboration between NCATS, and the National Institute of Arthritis and Musculoskeletal and Skin Diseases (U54 AR057319), and has received funding from the National Center for Research Resources (U54 RR019497). S.Z. Aydin, Associate Professor in Rheumatology, Division of Rheumatology, University of Ottawa, Ottawa Hospital Research Institute; J.C. Robson, MRCP, PhD, Consultant Senior Lecturer, University of the West of England, and Honorary Senior Lecturer, University of Bristol, and Honorary Consultant in Rheumatology, University Hospitals Bristol NHS Trust; A.G. Sreih, MD, Assistant Professor of Medicine, Division of Rheumatology, University of Pennsylvania; C. Hill, MD, Professor, Discipline of Medicine, University of Adelaide, and Consultant Rheumatologist, The Queen Elizabeth Hospital; F. Alibaz-Oner, MD, Associate Professor of Rheumatology, Fatih Sultan Mehmet Training and Research Hospital; S. Mackie, MRCP, PhD, Associate Professor, Leeds Institute of Rheumatic and Musculoskeletal Medicine, and Honorary Consultant Rheumatologist, Leeds Teaching Hospitals NHS Trust; S. Beard, Bmus, Adelaide, Australia; A. Gul, MD, Professor of Rheumatology, Division of Rheumatology, Department of Internal Medicine, Istanbul University, Istanbul Faculty of Medicine; G. Hatemi, MD, Professor of Medicine, Division of Rheumatology, Department of Internal Medicine, Istanbul University-Cerrahpasa, School of Medicine; T.A. Kermani, MD, MS, Associate Professor of Medicine, Division of Rheumatology, University of California at Los Angeles; A. Mahr, MD, PhD, Professor of Internal Medicine, Department of Internal Medicine, University Paris Diderot; A. Meara, MD, Assistant Professor, Division of Rheumatology and Immunology, The Ohio State University Wexner Medical Center; N. Milman, MD, Assistant Professor, Division of Rheumatology, University of Ottawa, and Division of Rheumatology, The Ottawa Hospital, and Department of Clinical Epidemiology, Ottawa Hospital Research Institute; B. Shea, PhD, Clinical Investigator and Adjunct Professor, Ottawa Hospital Research Institute, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; G. Tómasson, MD, PhD, Assistant Professor of Medicine, Department of Public Health Sciences, University of Iceland; P. Tugwell, MD, Professor, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; H. Direskeneli, MD, Professor of Medicine, Division of Rheumatology, Marmara University, School of Medicine; P.A. Merkel, MD, MPH, Professor of Medicine and Epidemiology, Division of Rheumatology and Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania. Address correspondence to Dr. P.A. Merkel, Chief, Division of Rheumatology, Professor of Medicine and Epidemiology, University of Pennsylvania, White Building, 5th Floor, 3400 Spruce St., Philadelphia, Pennsylvania 19104, USA. E-mail: pmerkel@upenn.edu. Accepted for publication February 20, 2019.
Alfred Mahr
From the Division of Rheumatology, University of Ottawa, Ottawa Hospital Research Institute; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Department of Clinical Epidemiology, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; University of the West of England; University of Bristol; University Hospitals Bristol National Health Service (NHS) Trust, Bristol; Leeds Institute of Rheumatic and Musculoskeletal Medicine; Leeds Teaching Hospitals NHS Trust, Leeds, UK; Division of Rheumatology and Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Rheumatology, University of California at Los Angeles, Los Angeles, California; Division of Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Discipline of Medicine, University of Adelaide; The Queen Elizabeth Hospital, Adelaide, Australia; Fatih Sultan Mehmet Training and Research Hospital; Division of Rheumatology, Department of Internal Medicine, Istanbul University, Istanbul Faculty of Medicine; Division of Rheumatology, Department of Internal Medicine, Istanbul University-Cerrahpasa, School of Medicine, Istanbul; Division of Rheumatology, Marmara University, School of Medicine, Marmara, Turkey; Department of Internal Medicine, University Paris Diderot, Paris, France; Department of Public Health Sciences, University of Iceland, Reykjavik, Iceland. This work was funded in part by the US Vasculitis Clinical Research Consortium (VCRC). The VCRC is part of the Rare Diseases Clinical Research Network, an initiative of the Office of Rare Diseases Research, National Center for Advancing Translational Science (NCATS). The VCRC is funded through collaboration between NCATS, and the National Institute of Arthritis and Musculoskeletal and Skin Diseases (U54 AR057319), and has received funding from the National Center for Research Resources (U54 RR019497). S.Z. Aydin, Associate Professor in Rheumatology, Division of Rheumatology, University of Ottawa, Ottawa Hospital Research Institute; J.C. Robson, MRCP, PhD, Consultant Senior Lecturer, University of the West of England, and Honorary Senior Lecturer, University of Bristol, and Honorary Consultant in Rheumatology, University Hospitals Bristol NHS Trust; A.G. Sreih, MD, Assistant Professor of Medicine, Division of Rheumatology, University of Pennsylvania; C. Hill, MD, Professor, Discipline of Medicine, University of Adelaide, and Consultant Rheumatologist, The Queen Elizabeth Hospital; F. Alibaz-Oner, MD, Associate Professor of Rheumatology, Fatih Sultan Mehmet Training and Research Hospital; S. Mackie, MRCP, PhD, Associate Professor, Leeds Institute of Rheumatic and Musculoskeletal Medicine, and Honorary Consultant Rheumatologist, Leeds Teaching Hospitals NHS Trust; S. Beard, Bmus, Adelaide, Australia; A. Gul, MD, Professor of Rheumatology, Division of Rheumatology, Department of Internal Medicine, Istanbul University, Istanbul Faculty of Medicine; G. Hatemi, MD, Professor of Medicine, Division of Rheumatology, Department of Internal Medicine, Istanbul University-Cerrahpasa, School of Medicine; T.A. Kermani, MD, MS, Associate Professor of Medicine, Division of Rheumatology, University of California at Los Angeles; A. Mahr, MD, PhD, Professor of Internal Medicine, Department of Internal Medicine, University Paris Diderot; A. Meara, MD, Assistant Professor, Division of Rheumatology and Immunology, The Ohio State University Wexner Medical Center; N. Milman, MD, Assistant Professor, Division of Rheumatology, University of Ottawa, and Division of Rheumatology, The Ottawa Hospital, and Department of Clinical Epidemiology, Ottawa Hospital Research Institute; B. Shea, PhD, Clinical Investigator and Adjunct Professor, Ottawa Hospital Research Institute, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; G. Tómasson, MD, PhD, Assistant Professor of Medicine, Department of Public Health Sciences, University of Iceland; P. Tugwell, MD, Professor, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; H. Direskeneli, MD, Professor of Medicine, Division of Rheumatology, Marmara University, School of Medicine; P.A. Merkel, MD, MPH, Professor of Medicine and Epidemiology, Division of Rheumatology and Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania. Address correspondence to Dr. P.A. Merkel, Chief, Division of Rheumatology, Professor of Medicine and Epidemiology, University of Pennsylvania, White Building, 5th Floor, 3400 Spruce St., Philadelphia, Pennsylvania 19104, USA. E-mail: pmerkel@upenn.edu. Accepted for publication February 20, 2019.
Alexa Meara
From the Division of Rheumatology, University of Ottawa, Ottawa Hospital Research Institute; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Department of Clinical Epidemiology, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; University of the West of England; University of Bristol; University Hospitals Bristol National Health Service (NHS) Trust, Bristol; Leeds Institute of Rheumatic and Musculoskeletal Medicine; Leeds Teaching Hospitals NHS Trust, Leeds, UK; Division of Rheumatology and Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Rheumatology, University of California at Los Angeles, Los Angeles, California; Division of Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Discipline of Medicine, University of Adelaide; The Queen Elizabeth Hospital, Adelaide, Australia; Fatih Sultan Mehmet Training and Research Hospital; Division of Rheumatology, Department of Internal Medicine, Istanbul University, Istanbul Faculty of Medicine; Division of Rheumatology, Department of Internal Medicine, Istanbul University-Cerrahpasa, School of Medicine, Istanbul; Division of Rheumatology, Marmara University, School of Medicine, Marmara, Turkey; Department of Internal Medicine, University Paris Diderot, Paris, France; Department of Public Health Sciences, University of Iceland, Reykjavik, Iceland. This work was funded in part by the US Vasculitis Clinical Research Consortium (VCRC). The VCRC is part of the Rare Diseases Clinical Research Network, an initiative of the Office of Rare Diseases Research, National Center for Advancing Translational Science (NCATS). The VCRC is funded through collaboration between NCATS, and the National Institute of Arthritis and Musculoskeletal and Skin Diseases (U54 AR057319), and has received funding from the National Center for Research Resources (U54 RR019497). S.Z. Aydin, Associate Professor in Rheumatology, Division of Rheumatology, University of Ottawa, Ottawa Hospital Research Institute; J.C. Robson, MRCP, PhD, Consultant Senior Lecturer, University of the West of England, and Honorary Senior Lecturer, University of Bristol, and Honorary Consultant in Rheumatology, University Hospitals Bristol NHS Trust; A.G. Sreih, MD, Assistant Professor of Medicine, Division of Rheumatology, University of Pennsylvania; C. Hill, MD, Professor, Discipline of Medicine, University of Adelaide, and Consultant Rheumatologist, The Queen Elizabeth Hospital; F. Alibaz-Oner, MD, Associate Professor of Rheumatology, Fatih Sultan Mehmet Training and Research Hospital; S. Mackie, MRCP, PhD, Associate Professor, Leeds Institute of Rheumatic and Musculoskeletal Medicine, and Honorary Consultant Rheumatologist, Leeds Teaching Hospitals NHS Trust; S. Beard, Bmus, Adelaide, Australia; A. Gul, MD, Professor of Rheumatology, Division of Rheumatology, Department of Internal Medicine, Istanbul University, Istanbul Faculty of Medicine; G. Hatemi, MD, Professor of Medicine, Division of Rheumatology, Department of Internal Medicine, Istanbul University-Cerrahpasa, School of Medicine; T.A. Kermani, MD, MS, Associate Professor of Medicine, Division of Rheumatology, University of California at Los Angeles; A. Mahr, MD, PhD, Professor of Internal Medicine, Department of Internal Medicine, University Paris Diderot; A. Meara, MD, Assistant Professor, Division of Rheumatology and Immunology, The Ohio State University Wexner Medical Center; N. Milman, MD, Assistant Professor, Division of Rheumatology, University of Ottawa, and Division of Rheumatology, The Ottawa Hospital, and Department of Clinical Epidemiology, Ottawa Hospital Research Institute; B. Shea, PhD, Clinical Investigator and Adjunct Professor, Ottawa Hospital Research Institute, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; G. Tómasson, MD, PhD, Assistant Professor of Medicine, Department of Public Health Sciences, University of Iceland; P. Tugwell, MD, Professor, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; H. Direskeneli, MD, Professor of Medicine, Division of Rheumatology, Marmara University, School of Medicine; P.A. Merkel, MD, MPH, Professor of Medicine and Epidemiology, Division of Rheumatology and Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania. Address correspondence to Dr. P.A. Merkel, Chief, Division of Rheumatology, Professor of Medicine and Epidemiology, University of Pennsylvania, White Building, 5th Floor, 3400 Spruce St., Philadelphia, Pennsylvania 19104, USA. E-mail: pmerkel@upenn.edu. Accepted for publication February 20, 2019.
Nataliya Milman
From the Division of Rheumatology, University of Ottawa, Ottawa Hospital Research Institute; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Department of Clinical Epidemiology, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; University of the West of England; University of Bristol; University Hospitals Bristol National Health Service (NHS) Trust, Bristol; Leeds Institute of Rheumatic and Musculoskeletal Medicine; Leeds Teaching Hospitals NHS Trust, Leeds, UK; Division of Rheumatology and Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Rheumatology, University of California at Los Angeles, Los Angeles, California; Division of Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Discipline of Medicine, University of Adelaide; The Queen Elizabeth Hospital, Adelaide, Australia; Fatih Sultan Mehmet Training and Research Hospital; Division of Rheumatology, Department of Internal Medicine, Istanbul University, Istanbul Faculty of Medicine; Division of Rheumatology, Department of Internal Medicine, Istanbul University-Cerrahpasa, School of Medicine, Istanbul; Division of Rheumatology, Marmara University, School of Medicine, Marmara, Turkey; Department of Internal Medicine, University Paris Diderot, Paris, France; Department of Public Health Sciences, University of Iceland, Reykjavik, Iceland. This work was funded in part by the US Vasculitis Clinical Research Consortium (VCRC). The VCRC is part of the Rare Diseases Clinical Research Network, an initiative of the Office of Rare Diseases Research, National Center for Advancing Translational Science (NCATS). The VCRC is funded through collaboration between NCATS, and the National Institute of Arthritis and Musculoskeletal and Skin Diseases (U54 AR057319), and has received funding from the National Center for Research Resources (U54 RR019497). S.Z. Aydin, Associate Professor in Rheumatology, Division of Rheumatology, University of Ottawa, Ottawa Hospital Research Institute; J.C. Robson, MRCP, PhD, Consultant Senior Lecturer, University of the West of England, and Honorary Senior Lecturer, University of Bristol, and Honorary Consultant in Rheumatology, University Hospitals Bristol NHS Trust; A.G. Sreih, MD, Assistant Professor of Medicine, Division of Rheumatology, University of Pennsylvania; C. Hill, MD, Professor, Discipline of Medicine, University of Adelaide, and Consultant Rheumatologist, The Queen Elizabeth Hospital; F. Alibaz-Oner, MD, Associate Professor of Rheumatology, Fatih Sultan Mehmet Training and Research Hospital; S. Mackie, MRCP, PhD, Associate Professor, Leeds Institute of Rheumatic and Musculoskeletal Medicine, and Honorary Consultant Rheumatologist, Leeds Teaching Hospitals NHS Trust; S. Beard, Bmus, Adelaide, Australia; A. Gul, MD, Professor of Rheumatology, Division of Rheumatology, Department of Internal Medicine, Istanbul University, Istanbul Faculty of Medicine; G. Hatemi, MD, Professor of Medicine, Division of Rheumatology, Department of Internal Medicine, Istanbul University-Cerrahpasa, School of Medicine; T.A. Kermani, MD, MS, Associate Professor of Medicine, Division of Rheumatology, University of California at Los Angeles; A. Mahr, MD, PhD, Professor of Internal Medicine, Department of Internal Medicine, University Paris Diderot; A. Meara, MD, Assistant Professor, Division of Rheumatology and Immunology, The Ohio State University Wexner Medical Center; N. Milman, MD, Assistant Professor, Division of Rheumatology, University of Ottawa, and Division of Rheumatology, The Ottawa Hospital, and Department of Clinical Epidemiology, Ottawa Hospital Research Institute; B. Shea, PhD, Clinical Investigator and Adjunct Professor, Ottawa Hospital Research Institute, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; G. Tómasson, MD, PhD, Assistant Professor of Medicine, Department of Public Health Sciences, University of Iceland; P. Tugwell, MD, Professor, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; H. Direskeneli, MD, Professor of Medicine, Division of Rheumatology, Marmara University, School of Medicine; P.A. Merkel, MD, MPH, Professor of Medicine and Epidemiology, Division of Rheumatology and Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania. Address correspondence to Dr. P.A. Merkel, Chief, Division of Rheumatology, Professor of Medicine and Epidemiology, University of Pennsylvania, White Building, 5th Floor, 3400 Spruce St., Philadelphia, Pennsylvania 19104, USA. E-mail: pmerkel@upenn.edu. Accepted for publication February 20, 2019.
Beverley Shea
From the Division of Rheumatology, University of Ottawa, Ottawa Hospital Research Institute; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Department of Clinical Epidemiology, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; University of the West of England; University of Bristol; University Hospitals Bristol National Health Service (NHS) Trust, Bristol; Leeds Institute of Rheumatic and Musculoskeletal Medicine; Leeds Teaching Hospitals NHS Trust, Leeds, UK; Division of Rheumatology and Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Rheumatology, University of California at Los Angeles, Los Angeles, California; Division of Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Discipline of Medicine, University of Adelaide; The Queen Elizabeth Hospital, Adelaide, Australia; Fatih Sultan Mehmet Training and Research Hospital; Division of Rheumatology, Department of Internal Medicine, Istanbul University, Istanbul Faculty of Medicine; Division of Rheumatology, Department of Internal Medicine, Istanbul University-Cerrahpasa, School of Medicine, Istanbul; Division of Rheumatology, Marmara University, School of Medicine, Marmara, Turkey; Department of Internal Medicine, University Paris Diderot, Paris, France; Department of Public Health Sciences, University of Iceland, Reykjavik, Iceland. This work was funded in part by the US Vasculitis Clinical Research Consortium (VCRC). The VCRC is part of the Rare Diseases Clinical Research Network, an initiative of the Office of Rare Diseases Research, National Center for Advancing Translational Science (NCATS). The VCRC is funded through collaboration between NCATS, and the National Institute of Arthritis and Musculoskeletal and Skin Diseases (U54 AR057319), and has received funding from the National Center for Research Resources (U54 RR019497). S.Z. Aydin, Associate Professor in Rheumatology, Division of Rheumatology, University of Ottawa, Ottawa Hospital Research Institute; J.C. Robson, MRCP, PhD, Consultant Senior Lecturer, University of the West of England, and Honorary Senior Lecturer, University of Bristol, and Honorary Consultant in Rheumatology, University Hospitals Bristol NHS Trust; A.G. Sreih, MD, Assistant Professor of Medicine, Division of Rheumatology, University of Pennsylvania; C. Hill, MD, Professor, Discipline of Medicine, University of Adelaide, and Consultant Rheumatologist, The Queen Elizabeth Hospital; F. Alibaz-Oner, MD, Associate Professor of Rheumatology, Fatih Sultan Mehmet Training and Research Hospital; S. Mackie, MRCP, PhD, Associate Professor, Leeds Institute of Rheumatic and Musculoskeletal Medicine, and Honorary Consultant Rheumatologist, Leeds Teaching Hospitals NHS Trust; S. Beard, Bmus, Adelaide, Australia; A. Gul, MD, Professor of Rheumatology, Division of Rheumatology, Department of Internal Medicine, Istanbul University, Istanbul Faculty of Medicine; G. Hatemi, MD, Professor of Medicine, Division of Rheumatology, Department of Internal Medicine, Istanbul University-Cerrahpasa, School of Medicine; T.A. Kermani, MD, MS, Associate Professor of Medicine, Division of Rheumatology, University of California at Los Angeles; A. Mahr, MD, PhD, Professor of Internal Medicine, Department of Internal Medicine, University Paris Diderot; A. Meara, MD, Assistant Professor, Division of Rheumatology and Immunology, The Ohio State University Wexner Medical Center; N. Milman, MD, Assistant Professor, Division of Rheumatology, University of Ottawa, and Division of Rheumatology, The Ottawa Hospital, and Department of Clinical Epidemiology, Ottawa Hospital Research Institute; B. Shea, PhD, Clinical Investigator and Adjunct Professor, Ottawa Hospital Research Institute, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; G. Tómasson, MD, PhD, Assistant Professor of Medicine, Department of Public Health Sciences, University of Iceland; P. Tugwell, MD, Professor, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; H. Direskeneli, MD, Professor of Medicine, Division of Rheumatology, Marmara University, School of Medicine; P.A. Merkel, MD, MPH, Professor of Medicine and Epidemiology, Division of Rheumatology and Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania. Address correspondence to Dr. P.A. Merkel, Chief, Division of Rheumatology, Professor of Medicine and Epidemiology, University of Pennsylvania, White Building, 5th Floor, 3400 Spruce St., Philadelphia, Pennsylvania 19104, USA. E-mail: pmerkel@upenn.edu. Accepted for publication February 20, 2019.
Gunnar Tómasson
From the Division of Rheumatology, University of Ottawa, Ottawa Hospital Research Institute; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Department of Clinical Epidemiology, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; University of the West of England; University of Bristol; University Hospitals Bristol National Health Service (NHS) Trust, Bristol; Leeds Institute of Rheumatic and Musculoskeletal Medicine; Leeds Teaching Hospitals NHS Trust, Leeds, UK; Division of Rheumatology and Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Rheumatology, University of California at Los Angeles, Los Angeles, California; Division of Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Discipline of Medicine, University of Adelaide; The Queen Elizabeth Hospital, Adelaide, Australia; Fatih Sultan Mehmet Training and Research Hospital; Division of Rheumatology, Department of Internal Medicine, Istanbul University, Istanbul Faculty of Medicine; Division of Rheumatology, Department of Internal Medicine, Istanbul University-Cerrahpasa, School of Medicine, Istanbul; Division of Rheumatology, Marmara University, School of Medicine, Marmara, Turkey; Department of Internal Medicine, University Paris Diderot, Paris, France; Department of Public Health Sciences, University of Iceland, Reykjavik, Iceland. This work was funded in part by the US Vasculitis Clinical Research Consortium (VCRC). The VCRC is part of the Rare Diseases Clinical Research Network, an initiative of the Office of Rare Diseases Research, National Center for Advancing Translational Science (NCATS). The VCRC is funded through collaboration between NCATS, and the National Institute of Arthritis and Musculoskeletal and Skin Diseases (U54 AR057319), and has received funding from the National Center for Research Resources (U54 RR019497). S.Z. Aydin, Associate Professor in Rheumatology, Division of Rheumatology, University of Ottawa, Ottawa Hospital Research Institute; J.C. Robson, MRCP, PhD, Consultant Senior Lecturer, University of the West of England, and Honorary Senior Lecturer, University of Bristol, and Honorary Consultant in Rheumatology, University Hospitals Bristol NHS Trust; A.G. Sreih, MD, Assistant Professor of Medicine, Division of Rheumatology, University of Pennsylvania; C. Hill, MD, Professor, Discipline of Medicine, University of Adelaide, and Consultant Rheumatologist, The Queen Elizabeth Hospital; F. Alibaz-Oner, MD, Associate Professor of Rheumatology, Fatih Sultan Mehmet Training and Research Hospital; S. Mackie, MRCP, PhD, Associate Professor, Leeds Institute of Rheumatic and Musculoskeletal Medicine, and Honorary Consultant Rheumatologist, Leeds Teaching Hospitals NHS Trust; S. Beard, Bmus, Adelaide, Australia; A. Gul, MD, Professor of Rheumatology, Division of Rheumatology, Department of Internal Medicine, Istanbul University, Istanbul Faculty of Medicine; G. Hatemi, MD, Professor of Medicine, Division of Rheumatology, Department of Internal Medicine, Istanbul University-Cerrahpasa, School of Medicine; T.A. Kermani, MD, MS, Associate Professor of Medicine, Division of Rheumatology, University of California at Los Angeles; A. Mahr, MD, PhD, Professor of Internal Medicine, Department of Internal Medicine, University Paris Diderot; A. Meara, MD, Assistant Professor, Division of Rheumatology and Immunology, The Ohio State University Wexner Medical Center; N. Milman, MD, Assistant Professor, Division of Rheumatology, University of Ottawa, and Division of Rheumatology, The Ottawa Hospital, and Department of Clinical Epidemiology, Ottawa Hospital Research Institute; B. Shea, PhD, Clinical Investigator and Adjunct Professor, Ottawa Hospital Research Institute, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; G. Tómasson, MD, PhD, Assistant Professor of Medicine, Department of Public Health Sciences, University of Iceland; P. Tugwell, MD, Professor, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; H. Direskeneli, MD, Professor of Medicine, Division of Rheumatology, Marmara University, School of Medicine; P.A. Merkel, MD, MPH, Professor of Medicine and Epidemiology, Division of Rheumatology and Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania. Address correspondence to Dr. P.A. Merkel, Chief, Division of Rheumatology, Professor of Medicine and Epidemiology, University of Pennsylvania, White Building, 5th Floor, 3400 Spruce St., Philadelphia, Pennsylvania 19104, USA. E-mail: pmerkel@upenn.edu. Accepted for publication February 20, 2019.
Peter Tugwell
From the Division of Rheumatology, University of Ottawa, Ottawa Hospital Research Institute; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Department of Clinical Epidemiology, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; University of the West of England; University of Bristol; University Hospitals Bristol National Health Service (NHS) Trust, Bristol; Leeds Institute of Rheumatic and Musculoskeletal Medicine; Leeds Teaching Hospitals NHS Trust, Leeds, UK; Division of Rheumatology and Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Rheumatology, University of California at Los Angeles, Los Angeles, California; Division of Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Discipline of Medicine, University of Adelaide; The Queen Elizabeth Hospital, Adelaide, Australia; Fatih Sultan Mehmet Training and Research Hospital; Division of Rheumatology, Department of Internal Medicine, Istanbul University, Istanbul Faculty of Medicine; Division of Rheumatology, Department of Internal Medicine, Istanbul University-Cerrahpasa, School of Medicine, Istanbul; Division of Rheumatology, Marmara University, School of Medicine, Marmara, Turkey; Department of Internal Medicine, University Paris Diderot, Paris, France; Department of Public Health Sciences, University of Iceland, Reykjavik, Iceland. This work was funded in part by the US Vasculitis Clinical Research Consortium (VCRC). The VCRC is part of the Rare Diseases Clinical Research Network, an initiative of the Office of Rare Diseases Research, National Center for Advancing Translational Science (NCATS). The VCRC is funded through collaboration between NCATS, and the National Institute of Arthritis and Musculoskeletal and Skin Diseases (U54 AR057319), and has received funding from the National Center for Research Resources (U54 RR019497). S.Z. Aydin, Associate Professor in Rheumatology, Division of Rheumatology, University of Ottawa, Ottawa Hospital Research Institute; J.C. Robson, MRCP, PhD, Consultant Senior Lecturer, University of the West of England, and Honorary Senior Lecturer, University of Bristol, and Honorary Consultant in Rheumatology, University Hospitals Bristol NHS Trust; A.G. Sreih, MD, Assistant Professor of Medicine, Division of Rheumatology, University of Pennsylvania; C. Hill, MD, Professor, Discipline of Medicine, University of Adelaide, and Consultant Rheumatologist, The Queen Elizabeth Hospital; F. Alibaz-Oner, MD, Associate Professor of Rheumatology, Fatih Sultan Mehmet Training and Research Hospital; S. Mackie, MRCP, PhD, Associate Professor, Leeds Institute of Rheumatic and Musculoskeletal Medicine, and Honorary Consultant Rheumatologist, Leeds Teaching Hospitals NHS Trust; S. Beard, Bmus, Adelaide, Australia; A. Gul, MD, Professor of Rheumatology, Division of Rheumatology, Department of Internal Medicine, Istanbul University, Istanbul Faculty of Medicine; G. Hatemi, MD, Professor of Medicine, Division of Rheumatology, Department of Internal Medicine, Istanbul University-Cerrahpasa, School of Medicine; T.A. Kermani, MD, MS, Associate Professor of Medicine, Division of Rheumatology, University of California at Los Angeles; A. Mahr, MD, PhD, Professor of Internal Medicine, Department of Internal Medicine, University Paris Diderot; A. Meara, MD, Assistant Professor, Division of Rheumatology and Immunology, The Ohio State University Wexner Medical Center; N. Milman, MD, Assistant Professor, Division of Rheumatology, University of Ottawa, and Division of Rheumatology, The Ottawa Hospital, and Department of Clinical Epidemiology, Ottawa Hospital Research Institute; B. Shea, PhD, Clinical Investigator and Adjunct Professor, Ottawa Hospital Research Institute, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; G. Tómasson, MD, PhD, Assistant Professor of Medicine, Department of Public Health Sciences, University of Iceland; P. Tugwell, MD, Professor, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; H. Direskeneli, MD, Professor of Medicine, Division of Rheumatology, Marmara University, School of Medicine; P.A. Merkel, MD, MPH, Professor of Medicine and Epidemiology, Division of Rheumatology and Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania. Address correspondence to Dr. P.A. Merkel, Chief, Division of Rheumatology, Professor of Medicine and Epidemiology, University of Pennsylvania, White Building, 5th Floor, 3400 Spruce St., Philadelphia, Pennsylvania 19104, USA. E-mail: pmerkel@upenn.edu. Accepted for publication February 20, 2019.
Haner Direskeneli
From the Division of Rheumatology, University of Ottawa, Ottawa Hospital Research Institute; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Department of Clinical Epidemiology, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; University of the West of England; University of Bristol; University Hospitals Bristol National Health Service (NHS) Trust, Bristol; Leeds Institute of Rheumatic and Musculoskeletal Medicine; Leeds Teaching Hospitals NHS Trust, Leeds, UK; Division of Rheumatology and Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Rheumatology, University of California at Los Angeles, Los Angeles, California; Division of Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Discipline of Medicine, University of Adelaide; The Queen Elizabeth Hospital, Adelaide, Australia; Fatih Sultan Mehmet Training and Research Hospital; Division of Rheumatology, Department of Internal Medicine, Istanbul University, Istanbul Faculty of Medicine; Division of Rheumatology, Department of Internal Medicine, Istanbul University-Cerrahpasa, School of Medicine, Istanbul; Division of Rheumatology, Marmara University, School of Medicine, Marmara, Turkey; Department of Internal Medicine, University Paris Diderot, Paris, France; Department of Public Health Sciences, University of Iceland, Reykjavik, Iceland. This work was funded in part by the US Vasculitis Clinical Research Consortium (VCRC). The VCRC is part of the Rare Diseases Clinical Research Network, an initiative of the Office of Rare Diseases Research, National Center for Advancing Translational Science (NCATS). The VCRC is funded through collaboration between NCATS, and the National Institute of Arthritis and Musculoskeletal and Skin Diseases (U54 AR057319), and has received funding from the National Center for Research Resources (U54 RR019497). S.Z. Aydin, Associate Professor in Rheumatology, Division of Rheumatology, University of Ottawa, Ottawa Hospital Research Institute; J.C. Robson, MRCP, PhD, Consultant Senior Lecturer, University of the West of England, and Honorary Senior Lecturer, University of Bristol, and Honorary Consultant in Rheumatology, University Hospitals Bristol NHS Trust; A.G. Sreih, MD, Assistant Professor of Medicine, Division of Rheumatology, University of Pennsylvania; C. Hill, MD, Professor, Discipline of Medicine, University of Adelaide, and Consultant Rheumatologist, The Queen Elizabeth Hospital; F. Alibaz-Oner, MD, Associate Professor of Rheumatology, Fatih Sultan Mehmet Training and Research Hospital; S. Mackie, MRCP, PhD, Associate Professor, Leeds Institute of Rheumatic and Musculoskeletal Medicine, and Honorary Consultant Rheumatologist, Leeds Teaching Hospitals NHS Trust; S. Beard, Bmus, Adelaide, Australia; A. Gul, MD, Professor of Rheumatology, Division of Rheumatology, Department of Internal Medicine, Istanbul University, Istanbul Faculty of Medicine; G. Hatemi, MD, Professor of Medicine, Division of Rheumatology, Department of Internal Medicine, Istanbul University-Cerrahpasa, School of Medicine; T.A. Kermani, MD, MS, Associate Professor of Medicine, Division of Rheumatology, University of California at Los Angeles; A. Mahr, MD, PhD, Professor of Internal Medicine, Department of Internal Medicine, University Paris Diderot; A. Meara, MD, Assistant Professor, Division of Rheumatology and Immunology, The Ohio State University Wexner Medical Center; N. Milman, MD, Assistant Professor, Division of Rheumatology, University of Ottawa, and Division of Rheumatology, The Ottawa Hospital, and Department of Clinical Epidemiology, Ottawa Hospital Research Institute; B. Shea, PhD, Clinical Investigator and Adjunct Professor, Ottawa Hospital Research Institute, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; G. Tómasson, MD, PhD, Assistant Professor of Medicine, Department of Public Health Sciences, University of Iceland; P. Tugwell, MD, Professor, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; H. Direskeneli, MD, Professor of Medicine, Division of Rheumatology, Marmara University, School of Medicine; P.A. Merkel, MD, MPH, Professor of Medicine and Epidemiology, Division of Rheumatology and Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania. Address correspondence to Dr. P.A. Merkel, Chief, Division of Rheumatology, Professor of Medicine and Epidemiology, University of Pennsylvania, White Building, 5th Floor, 3400 Spruce St., Philadelphia, Pennsylvania 19104, USA. E-mail: pmerkel@upenn.edu. Accepted for publication February 20, 2019.
Peter A. Merkel
From the Division of Rheumatology, University of Ottawa, Ottawa Hospital Research Institute; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Department of Clinical Epidemiology, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; University of the West of England; University of Bristol; University Hospitals Bristol National Health Service (NHS) Trust, Bristol; Leeds Institute of Rheumatic and Musculoskeletal Medicine; Leeds Teaching Hospitals NHS Trust, Leeds, UK; Division of Rheumatology and Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Rheumatology, University of California at Los Angeles, Los Angeles, California; Division of Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Discipline of Medicine, University of Adelaide; The Queen Elizabeth Hospital, Adelaide, Australia; Fatih Sultan Mehmet Training and Research Hospital; Division of Rheumatology, Department of Internal Medicine, Istanbul University, Istanbul Faculty of Medicine; Division of Rheumatology, Department of Internal Medicine, Istanbul University-Cerrahpasa, School of Medicine, Istanbul; Division of Rheumatology, Marmara University, School of Medicine, Marmara, Turkey; Department of Internal Medicine, University Paris Diderot, Paris, France; Department of Public Health Sciences, University of Iceland, Reykjavik, Iceland. This work was funded in part by the US Vasculitis Clinical Research Consortium (VCRC). The VCRC is part of the Rare Diseases Clinical Research Network, an initiative of the Office of Rare Diseases Research, National Center for Advancing Translational Science (NCATS). The VCRC is funded through collaboration between NCATS, and the National Institute of Arthritis and Musculoskeletal and Skin Diseases (U54 AR057319), and has received funding from the National Center for Research Resources (U54 RR019497). S.Z. Aydin, Associate Professor in Rheumatology, Division of Rheumatology, University of Ottawa, Ottawa Hospital Research Institute; J.C. Robson, MRCP, PhD, Consultant Senior Lecturer, University of the West of England, and Honorary Senior Lecturer, University of Bristol, and Honorary Consultant in Rheumatology, University Hospitals Bristol NHS Trust; A.G. Sreih, MD, Assistant Professor of Medicine, Division of Rheumatology, University of Pennsylvania; C. Hill, MD, Professor, Discipline of Medicine, University of Adelaide, and Consultant Rheumatologist, The Queen Elizabeth Hospital; F. Alibaz-Oner, MD, Associate Professor of Rheumatology, Fatih Sultan Mehmet Training and Research Hospital; S. Mackie, MRCP, PhD, Associate Professor, Leeds Institute of Rheumatic and Musculoskeletal Medicine, and Honorary Consultant Rheumatologist, Leeds Teaching Hospitals NHS Trust; S. Beard, Bmus, Adelaide, Australia; A. Gul, MD, Professor of Rheumatology, Division of Rheumatology, Department of Internal Medicine, Istanbul University, Istanbul Faculty of Medicine; G. Hatemi, MD, Professor of Medicine, Division of Rheumatology, Department of Internal Medicine, Istanbul University-Cerrahpasa, School of Medicine; T.A. Kermani, MD, MS, Associate Professor of Medicine, Division of Rheumatology, University of California at Los Angeles; A. Mahr, MD, PhD, Professor of Internal Medicine, Department of Internal Medicine, University Paris Diderot; A. Meara, MD, Assistant Professor, Division of Rheumatology and Immunology, The Ohio State University Wexner Medical Center; N. Milman, MD, Assistant Professor, Division of Rheumatology, University of Ottawa, and Division of Rheumatology, The Ottawa Hospital, and Department of Clinical Epidemiology, Ottawa Hospital Research Institute; B. Shea, PhD, Clinical Investigator and Adjunct Professor, Ottawa Hospital Research Institute, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; G. Tómasson, MD, PhD, Assistant Professor of Medicine, Department of Public Health Sciences, University of Iceland; P. Tugwell, MD, Professor, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; H. Direskeneli, MD, Professor of Medicine, Division of Rheumatology, Marmara University, School of Medicine; P.A. Merkel, MD, MPH, Professor of Medicine and Epidemiology, Division of Rheumatology and Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania. Address correspondence to Dr. P.A. Merkel, Chief, Division of Rheumatology, Professor of Medicine and Epidemiology, University of Pennsylvania, White Building, 5th Floor, 3400 Spruce St., Philadelphia, Pennsylvania 19104, USA. E-mail: pmerkel@upenn.edu. Accepted for publication February 20, 2019.
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- Published online May 15, 2019.
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- Sibel Z. Aydin,
- Joanna C. Robson,
- Antoine G. Sreih,
- Catherine Hill,
- Fatma Alibaz-Oner,
- Sarah Mackie,
- Susan Beard,
- Ahmet Gul,
- Gülen Hatemi,
- Tanaz A. Kermani,
- Alfred Mahr,
- Alexa Meara,
- Nataliya Milman,
- Beverley Shea,
- Gunnar Tómasson,
- Peter Tugwell,
- Haner Direskeneli and
- Peter A. Merkel
- From the Division of Rheumatology, University of Ottawa, Ottawa Hospital Research Institute; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Department of Clinical Epidemiology, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; University of the West of England; University of Bristol; University Hospitals Bristol National Health Service (NHS) Trust, Bristol; Leeds Institute of Rheumatic and Musculoskeletal Medicine; Leeds Teaching Hospitals NHS Trust, Leeds, UK; Division of Rheumatology and Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Rheumatology, University of California at Los Angeles, Los Angeles, California; Division of Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Discipline of Medicine, University of Adelaide; The Queen Elizabeth Hospital, Adelaide, Australia; Fatih Sultan Mehmet Training and Research Hospital; Division of Rheumatology, Department of Internal Medicine, Istanbul University, Istanbul Faculty of Medicine; Division of Rheumatology, Department of Internal Medicine, Istanbul University-Cerrahpasa, School of Medicine, Istanbul; Division of Rheumatology, Marmara University, School of Medicine, Marmara, Turkey; Department of Internal Medicine, University Paris Diderot, Paris, France; Department of Public Health Sciences, University of Iceland, Reykjavik, Iceland.
This work was funded in part by the US Vasculitis Clinical Research Consortium (VCRC). The VCRC is part of the Rare Diseases Clinical Research Network, an initiative of the Office of Rare Diseases Research, National Center for Advancing Translational Science (NCATS). The VCRC is funded through collaboration between NCATS, and the National Institute of Arthritis and Musculoskeletal and Skin Diseases (U54 AR057319), and has received funding from the National Center for Research Resources (U54 RR019497).
S.Z. Aydin, Associate Professor in Rheumatology, Division of Rheumatology, University of Ottawa, Ottawa Hospital Research Institute; J.C. Robson, MRCP, PhD, Consultant Senior Lecturer, University of the West of England, and Honorary Senior Lecturer, University of Bristol, and Honorary Consultant in Rheumatology, University Hospitals Bristol NHS Trust; A.G. Sreih, MD, Assistant Professor of Medicine, Division of Rheumatology, University of Pennsylvania; C. Hill, MD, Professor, Discipline of Medicine, University of Adelaide, and Consultant Rheumatologist, The Queen Elizabeth Hospital; F. Alibaz-Oner, MD, Associate Professor of Rheumatology, Fatih Sultan Mehmet Training and Research Hospital; S. Mackie, MRCP, PhD, Associate Professor, Leeds Institute of Rheumatic and Musculoskeletal Medicine, and Honorary Consultant Rheumatologist, Leeds Teaching Hospitals NHS Trust; S. Beard, Bmus, Adelaide, Australia; A. Gul, MD, Professor of Rheumatology, Division of Rheumatology, Department of Internal Medicine, Istanbul University, Istanbul Faculty of Medicine; G. Hatemi, MD, Professor of Medicine, Division of Rheumatology, Department of Internal Medicine, Istanbul University-Cerrahpasa, School of Medicine; T.A. Kermani, MD, MS, Associate Professor of Medicine, Division of Rheumatology, University of California at Los Angeles; A. Mahr, MD, PhD, Professor of Internal Medicine, Department of Internal Medicine, University Paris Diderot; A. Meara, MD, Assistant Professor, Division of Rheumatology and Immunology, The Ohio State University Wexner Medical Center; N. Milman, MD, Assistant Professor, Division of Rheumatology, University of Ottawa, and Division of Rheumatology, The Ottawa Hospital, and Department of Clinical Epidemiology, Ottawa Hospital Research Institute; B. Shea, PhD, Clinical Investigator and Adjunct Professor, Ottawa Hospital Research Institute, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; G. Tómasson, MD, PhD, Assistant Professor of Medicine, Department of Public Health Sciences, University of Iceland; P. Tugwell, MD, Professor, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; H. Direskeneli, MD, Professor of Medicine, Division of Rheumatology, Marmara University, School of Medicine; P.A. Merkel, MD, MPH, Professor of Medicine and Epidemiology, Division of Rheumatology and Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania.
Address correspondence to Dr. P.A. Merkel, Chief, Division of Rheumatology, Professor of Medicine and Epidemiology, University of Pennsylvania, White Building, 5th Floor, 3400 Spruce St., Philadelphia, Pennsylvania 19104, USA. E-mail: pmerkel@upenn.edu.
Accepted for publication February 20, 2019.
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In this issue
The Journal of Rheumatology
Vol. 51, Issue 3
1 Mar 2024
Update on Outcome Measure Development in Large-vessel Vasculitis: Report from OMERACT 2018
Sibel Z. Aydin, Joanna C. Robson, Antoine G. Sreih, Catherine Hill, Fatma Alibaz-Oner, Sarah Mackie, Susan Beard, Ahmet Gul, Gülen Hatemi, Tanaz A. Kermani, Alfred Mahr, Alexa Meara, Nataliya Milman, Beverley Shea, Gunnar Tómasson, Peter Tugwell, Haner Direskeneli, Peter A. Merkel
The Journal of Rheumatology Mar 2019, jrheum.181072; DOI: 10.3899/jrheum.181072
Update on Outcome Measure Development in Large-vessel Vasculitis: Report from OMERACT 2018
Sibel Z. Aydin, Joanna C. Robson, Antoine G. Sreih, Catherine Hill, Fatma Alibaz-Oner, Sarah Mackie, Susan Beard, Ahmet Gul, Gülen Hatemi, Tanaz A. Kermani, Alfred Mahr, Alexa Meara, Nataliya Milman, Beverley Shea, Gunnar Tómasson, Peter Tugwell, Haner Direskeneli, Peter A. Merkel
The Journal of Rheumatology Mar 2019, jrheum.181072; DOI: 10.3899/jrheum.181072