Research ArticleArticle
Clinical Effect of Alpha-1 Antitrypsin Deficiency in Antineutrophil Cytoplasmic Antibody–associated Vasculitis: Results from a French Retrospective Monocentric Cohort
Samuel Deshayes, Nicolas Martin Silva, Frédérique Grandhomme, Kathy Khoy, Delphine Mariotte, Jonathan Boutemy, Gwénola Maigné, Claire Brière-Bellier, Claire Delmas, Boris Bienvenu, Thierry Lobbedez, Hubert de Boysson and Achille Aouba
The Journal of Rheumatology March 2019, jrheum.180591; DOI: https://doi.org/10.3899/jrheum.180591
Samuel Deshayes
From the Department of Internal Medicine, the Department of Biochemistry, the Department of Immunology, and the Department of Nephrology, Normandie Université, UNICAEN, Centre Hospitalier Universitaire (CHU) de Caen Normandie, Caen; Department of Infectious Diseases, CH Mémorial, Saint-Lô, France. S. Deshayes, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; N. Martin Silva, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; F. Grandhomme, MD, Department of Biochemistry, Normandie Université, UNICAEN, CHU de Caen Normandie; K. Khoy, PharmD, PhD, Department of Immunology, Normandie Université, UNICAEN, CHU de Caen Normandie; D. Mariotte, PharmD, Department of Immunology, Normandie Université, UNICAEN, CHU de Caen Normandie; J. Boutemy, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; G. Maigné, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; C. Brière-Bellier, MD, Department of Infectious Diseases, CH Mémorial; C. Delmas, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; B. Bienvenu, MD, PhD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; T. Lobbedez, MD, PhD, Department of Nephrology, Normandie Université, UNICAEN, CHU de Caen Normandie; H. de Boysson, MD, MSc, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; A. Aouba, MD, PhD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie. Address correspondence to Prof. A. Aouba, Department of Internal Medicine and Clinical Immunology, Normandie Université, UNICAEN, CHU de Caen Normandie, Avenue de la Côte de Nacre, 14000 Caen, France. E-mail: aouba-a@chu-caen.fr. Accepted for publication November 12, 2018.
Nicolas Martin Silva
From the Department of Internal Medicine, the Department of Biochemistry, the Department of Immunology, and the Department of Nephrology, Normandie Université, UNICAEN, Centre Hospitalier Universitaire (CHU) de Caen Normandie, Caen; Department of Infectious Diseases, CH Mémorial, Saint-Lô, France. S. Deshayes, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; N. Martin Silva, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; F. Grandhomme, MD, Department of Biochemistry, Normandie Université, UNICAEN, CHU de Caen Normandie; K. Khoy, PharmD, PhD, Department of Immunology, Normandie Université, UNICAEN, CHU de Caen Normandie; D. Mariotte, PharmD, Department of Immunology, Normandie Université, UNICAEN, CHU de Caen Normandie; J. Boutemy, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; G. Maigné, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; C. Brière-Bellier, MD, Department of Infectious Diseases, CH Mémorial; C. Delmas, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; B. Bienvenu, MD, PhD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; T. Lobbedez, MD, PhD, Department of Nephrology, Normandie Université, UNICAEN, CHU de Caen Normandie; H. de Boysson, MD, MSc, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; A. Aouba, MD, PhD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie. Address correspondence to Prof. A. Aouba, Department of Internal Medicine and Clinical Immunology, Normandie Université, UNICAEN, CHU de Caen Normandie, Avenue de la Côte de Nacre, 14000 Caen, France. E-mail: aouba-a@chu-caen.fr. Accepted for publication November 12, 2018.
Frédérique Grandhomme
From the Department of Internal Medicine, the Department of Biochemistry, the Department of Immunology, and the Department of Nephrology, Normandie Université, UNICAEN, Centre Hospitalier Universitaire (CHU) de Caen Normandie, Caen; Department of Infectious Diseases, CH Mémorial, Saint-Lô, France. S. Deshayes, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; N. Martin Silva, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; F. Grandhomme, MD, Department of Biochemistry, Normandie Université, UNICAEN, CHU de Caen Normandie; K. Khoy, PharmD, PhD, Department of Immunology, Normandie Université, UNICAEN, CHU de Caen Normandie; D. Mariotte, PharmD, Department of Immunology, Normandie Université, UNICAEN, CHU de Caen Normandie; J. Boutemy, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; G. Maigné, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; C. Brière-Bellier, MD, Department of Infectious Diseases, CH Mémorial; C. Delmas, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; B. Bienvenu, MD, PhD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; T. Lobbedez, MD, PhD, Department of Nephrology, Normandie Université, UNICAEN, CHU de Caen Normandie; H. de Boysson, MD, MSc, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; A. Aouba, MD, PhD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie. Address correspondence to Prof. A. Aouba, Department of Internal Medicine and Clinical Immunology, Normandie Université, UNICAEN, CHU de Caen Normandie, Avenue de la Côte de Nacre, 14000 Caen, France. E-mail: aouba-a@chu-caen.fr. Accepted for publication November 12, 2018.
Kathy Khoy
From the Department of Internal Medicine, the Department of Biochemistry, the Department of Immunology, and the Department of Nephrology, Normandie Université, UNICAEN, Centre Hospitalier Universitaire (CHU) de Caen Normandie, Caen; Department of Infectious Diseases, CH Mémorial, Saint-Lô, France. S. Deshayes, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; N. Martin Silva, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; F. Grandhomme, MD, Department of Biochemistry, Normandie Université, UNICAEN, CHU de Caen Normandie; K. Khoy, PharmD, PhD, Department of Immunology, Normandie Université, UNICAEN, CHU de Caen Normandie; D. Mariotte, PharmD, Department of Immunology, Normandie Université, UNICAEN, CHU de Caen Normandie; J. Boutemy, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; G. Maigné, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; C. Brière-Bellier, MD, Department of Infectious Diseases, CH Mémorial; C. Delmas, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; B. Bienvenu, MD, PhD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; T. Lobbedez, MD, PhD, Department of Nephrology, Normandie Université, UNICAEN, CHU de Caen Normandie; H. de Boysson, MD, MSc, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; A. Aouba, MD, PhD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie. Address correspondence to Prof. A. Aouba, Department of Internal Medicine and Clinical Immunology, Normandie Université, UNICAEN, CHU de Caen Normandie, Avenue de la Côte de Nacre, 14000 Caen, France. E-mail: aouba-a@chu-caen.fr. Accepted for publication November 12, 2018.
Delphine Mariotte
From the Department of Internal Medicine, the Department of Biochemistry, the Department of Immunology, and the Department of Nephrology, Normandie Université, UNICAEN, Centre Hospitalier Universitaire (CHU) de Caen Normandie, Caen; Department of Infectious Diseases, CH Mémorial, Saint-Lô, France. S. Deshayes, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; N. Martin Silva, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; F. Grandhomme, MD, Department of Biochemistry, Normandie Université, UNICAEN, CHU de Caen Normandie; K. Khoy, PharmD, PhD, Department of Immunology, Normandie Université, UNICAEN, CHU de Caen Normandie; D. Mariotte, PharmD, Department of Immunology, Normandie Université, UNICAEN, CHU de Caen Normandie; J. Boutemy, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; G. Maigné, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; C. Brière-Bellier, MD, Department of Infectious Diseases, CH Mémorial; C. Delmas, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; B. Bienvenu, MD, PhD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; T. Lobbedez, MD, PhD, Department of Nephrology, Normandie Université, UNICAEN, CHU de Caen Normandie; H. de Boysson, MD, MSc, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; A. Aouba, MD, PhD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie. Address correspondence to Prof. A. Aouba, Department of Internal Medicine and Clinical Immunology, Normandie Université, UNICAEN, CHU de Caen Normandie, Avenue de la Côte de Nacre, 14000 Caen, France. E-mail: aouba-a@chu-caen.fr. Accepted for publication November 12, 2018.
Jonathan Boutemy
From the Department of Internal Medicine, the Department of Biochemistry, the Department of Immunology, and the Department of Nephrology, Normandie Université, UNICAEN, Centre Hospitalier Universitaire (CHU) de Caen Normandie, Caen; Department of Infectious Diseases, CH Mémorial, Saint-Lô, France. S. Deshayes, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; N. Martin Silva, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; F. Grandhomme, MD, Department of Biochemistry, Normandie Université, UNICAEN, CHU de Caen Normandie; K. Khoy, PharmD, PhD, Department of Immunology, Normandie Université, UNICAEN, CHU de Caen Normandie; D. Mariotte, PharmD, Department of Immunology, Normandie Université, UNICAEN, CHU de Caen Normandie; J. Boutemy, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; G. Maigné, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; C. Brière-Bellier, MD, Department of Infectious Diseases, CH Mémorial; C. Delmas, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; B. Bienvenu, MD, PhD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; T. Lobbedez, MD, PhD, Department of Nephrology, Normandie Université, UNICAEN, CHU de Caen Normandie; H. de Boysson, MD, MSc, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; A. Aouba, MD, PhD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie. Address correspondence to Prof. A. Aouba, Department of Internal Medicine and Clinical Immunology, Normandie Université, UNICAEN, CHU de Caen Normandie, Avenue de la Côte de Nacre, 14000 Caen, France. E-mail: aouba-a@chu-caen.fr. Accepted for publication November 12, 2018.
Gwénola Maigné
From the Department of Internal Medicine, the Department of Biochemistry, the Department of Immunology, and the Department of Nephrology, Normandie Université, UNICAEN, Centre Hospitalier Universitaire (CHU) de Caen Normandie, Caen; Department of Infectious Diseases, CH Mémorial, Saint-Lô, France. S. Deshayes, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; N. Martin Silva, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; F. Grandhomme, MD, Department of Biochemistry, Normandie Université, UNICAEN, CHU de Caen Normandie; K. Khoy, PharmD, PhD, Department of Immunology, Normandie Université, UNICAEN, CHU de Caen Normandie; D. Mariotte, PharmD, Department of Immunology, Normandie Université, UNICAEN, CHU de Caen Normandie; J. Boutemy, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; G. Maigné, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; C. Brière-Bellier, MD, Department of Infectious Diseases, CH Mémorial; C. Delmas, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; B. Bienvenu, MD, PhD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; T. Lobbedez, MD, PhD, Department of Nephrology, Normandie Université, UNICAEN, CHU de Caen Normandie; H. de Boysson, MD, MSc, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; A. Aouba, MD, PhD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie. Address correspondence to Prof. A. Aouba, Department of Internal Medicine and Clinical Immunology, Normandie Université, UNICAEN, CHU de Caen Normandie, Avenue de la Côte de Nacre, 14000 Caen, France. E-mail: aouba-a@chu-caen.fr. Accepted for publication November 12, 2018.
Claire Brière-Bellier
From the Department of Internal Medicine, the Department of Biochemistry, the Department of Immunology, and the Department of Nephrology, Normandie Université, UNICAEN, Centre Hospitalier Universitaire (CHU) de Caen Normandie, Caen; Department of Infectious Diseases, CH Mémorial, Saint-Lô, France. S. Deshayes, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; N. Martin Silva, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; F. Grandhomme, MD, Department of Biochemistry, Normandie Université, UNICAEN, CHU de Caen Normandie; K. Khoy, PharmD, PhD, Department of Immunology, Normandie Université, UNICAEN, CHU de Caen Normandie; D. Mariotte, PharmD, Department of Immunology, Normandie Université, UNICAEN, CHU de Caen Normandie; J. Boutemy, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; G. Maigné, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; C. Brière-Bellier, MD, Department of Infectious Diseases, CH Mémorial; C. Delmas, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; B. Bienvenu, MD, PhD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; T. Lobbedez, MD, PhD, Department of Nephrology, Normandie Université, UNICAEN, CHU de Caen Normandie; H. de Boysson, MD, MSc, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; A. Aouba, MD, PhD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie. Address correspondence to Prof. A. Aouba, Department of Internal Medicine and Clinical Immunology, Normandie Université, UNICAEN, CHU de Caen Normandie, Avenue de la Côte de Nacre, 14000 Caen, France. E-mail: aouba-a@chu-caen.fr. Accepted for publication November 12, 2018.
Claire Delmas
From the Department of Internal Medicine, the Department of Biochemistry, the Department of Immunology, and the Department of Nephrology, Normandie Université, UNICAEN, Centre Hospitalier Universitaire (CHU) de Caen Normandie, Caen; Department of Infectious Diseases, CH Mémorial, Saint-Lô, France. S. Deshayes, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; N. Martin Silva, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; F. Grandhomme, MD, Department of Biochemistry, Normandie Université, UNICAEN, CHU de Caen Normandie; K. Khoy, PharmD, PhD, Department of Immunology, Normandie Université, UNICAEN, CHU de Caen Normandie; D. Mariotte, PharmD, Department of Immunology, Normandie Université, UNICAEN, CHU de Caen Normandie; J. Boutemy, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; G. Maigné, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; C. Brière-Bellier, MD, Department of Infectious Diseases, CH Mémorial; C. Delmas, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; B. Bienvenu, MD, PhD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; T. Lobbedez, MD, PhD, Department of Nephrology, Normandie Université, UNICAEN, CHU de Caen Normandie; H. de Boysson, MD, MSc, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; A. Aouba, MD, PhD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie. Address correspondence to Prof. A. Aouba, Department of Internal Medicine and Clinical Immunology, Normandie Université, UNICAEN, CHU de Caen Normandie, Avenue de la Côte de Nacre, 14000 Caen, France. E-mail: aouba-a@chu-caen.fr. Accepted for publication November 12, 2018.
Boris Bienvenu
From the Department of Internal Medicine, the Department of Biochemistry, the Department of Immunology, and the Department of Nephrology, Normandie Université, UNICAEN, Centre Hospitalier Universitaire (CHU) de Caen Normandie, Caen; Department of Infectious Diseases, CH Mémorial, Saint-Lô, France. S. Deshayes, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; N. Martin Silva, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; F. Grandhomme, MD, Department of Biochemistry, Normandie Université, UNICAEN, CHU de Caen Normandie; K. Khoy, PharmD, PhD, Department of Immunology, Normandie Université, UNICAEN, CHU de Caen Normandie; D. Mariotte, PharmD, Department of Immunology, Normandie Université, UNICAEN, CHU de Caen Normandie; J. Boutemy, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; G. Maigné, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; C. Brière-Bellier, MD, Department of Infectious Diseases, CH Mémorial; C. Delmas, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; B. Bienvenu, MD, PhD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; T. Lobbedez, MD, PhD, Department of Nephrology, Normandie Université, UNICAEN, CHU de Caen Normandie; H. de Boysson, MD, MSc, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; A. Aouba, MD, PhD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie. Address correspondence to Prof. A. Aouba, Department of Internal Medicine and Clinical Immunology, Normandie Université, UNICAEN, CHU de Caen Normandie, Avenue de la Côte de Nacre, 14000 Caen, France. E-mail: aouba-a@chu-caen.fr. Accepted for publication November 12, 2018.
Thierry Lobbedez
From the Department of Internal Medicine, the Department of Biochemistry, the Department of Immunology, and the Department of Nephrology, Normandie Université, UNICAEN, Centre Hospitalier Universitaire (CHU) de Caen Normandie, Caen; Department of Infectious Diseases, CH Mémorial, Saint-Lô, France. S. Deshayes, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; N. Martin Silva, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; F. Grandhomme, MD, Department of Biochemistry, Normandie Université, UNICAEN, CHU de Caen Normandie; K. Khoy, PharmD, PhD, Department of Immunology, Normandie Université, UNICAEN, CHU de Caen Normandie; D. Mariotte, PharmD, Department of Immunology, Normandie Université, UNICAEN, CHU de Caen Normandie; J. Boutemy, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; G. Maigné, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; C. Brière-Bellier, MD, Department of Infectious Diseases, CH Mémorial; C. Delmas, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; B. Bienvenu, MD, PhD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; T. Lobbedez, MD, PhD, Department of Nephrology, Normandie Université, UNICAEN, CHU de Caen Normandie; H. de Boysson, MD, MSc, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; A. Aouba, MD, PhD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie. Address correspondence to Prof. A. Aouba, Department of Internal Medicine and Clinical Immunology, Normandie Université, UNICAEN, CHU de Caen Normandie, Avenue de la Côte de Nacre, 14000 Caen, France. E-mail: aouba-a@chu-caen.fr. Accepted for publication November 12, 2018.
Hubert de Boysson
From the Department of Internal Medicine, the Department of Biochemistry, the Department of Immunology, and the Department of Nephrology, Normandie Université, UNICAEN, Centre Hospitalier Universitaire (CHU) de Caen Normandie, Caen; Department of Infectious Diseases, CH Mémorial, Saint-Lô, France. S. Deshayes, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; N. Martin Silva, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; F. Grandhomme, MD, Department of Biochemistry, Normandie Université, UNICAEN, CHU de Caen Normandie; K. Khoy, PharmD, PhD, Department of Immunology, Normandie Université, UNICAEN, CHU de Caen Normandie; D. Mariotte, PharmD, Department of Immunology, Normandie Université, UNICAEN, CHU de Caen Normandie; J. Boutemy, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; G. Maigné, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; C. Brière-Bellier, MD, Department of Infectious Diseases, CH Mémorial; C. Delmas, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; B. Bienvenu, MD, PhD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; T. Lobbedez, MD, PhD, Department of Nephrology, Normandie Université, UNICAEN, CHU de Caen Normandie; H. de Boysson, MD, MSc, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; A. Aouba, MD, PhD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie. Address correspondence to Prof. A. Aouba, Department of Internal Medicine and Clinical Immunology, Normandie Université, UNICAEN, CHU de Caen Normandie, Avenue de la Côte de Nacre, 14000 Caen, France. E-mail: aouba-a@chu-caen.fr. Accepted for publication November 12, 2018.
Achille Aouba
From the Department of Internal Medicine, the Department of Biochemistry, the Department of Immunology, and the Department of Nephrology, Normandie Université, UNICAEN, Centre Hospitalier Universitaire (CHU) de Caen Normandie, Caen; Department of Infectious Diseases, CH Mémorial, Saint-Lô, France. S. Deshayes, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; N. Martin Silva, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; F. Grandhomme, MD, Department of Biochemistry, Normandie Université, UNICAEN, CHU de Caen Normandie; K. Khoy, PharmD, PhD, Department of Immunology, Normandie Université, UNICAEN, CHU de Caen Normandie; D. Mariotte, PharmD, Department of Immunology, Normandie Université, UNICAEN, CHU de Caen Normandie; J. Boutemy, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; G. Maigné, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; C. Brière-Bellier, MD, Department of Infectious Diseases, CH Mémorial; C. Delmas, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; B. Bienvenu, MD, PhD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; T. Lobbedez, MD, PhD, Department of Nephrology, Normandie Université, UNICAEN, CHU de Caen Normandie; H. de Boysson, MD, MSc, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; A. Aouba, MD, PhD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie. Address correspondence to Prof. A. Aouba, Department of Internal Medicine and Clinical Immunology, Normandie Université, UNICAEN, CHU de Caen Normandie, Avenue de la Côte de Nacre, 14000 Caen, France. E-mail: aouba-a@chu-caen.fr. Accepted for publication November 12, 2018.
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- Samuel Deshayes,
- Nicolas Martin Silva,
- Frédérique Grandhomme,
- Kathy Khoy,
- Delphine Mariotte,
- Jonathan Boutemy,
- Gwénola Maigné,
- Claire Brière-Bellier,
- Claire Delmas,
- Boris Bienvenu,
- Thierry Lobbedez,
- Hubert de Boysson and
- Achille Aouba
- From the Department of Internal Medicine, the Department of Biochemistry, the Department of Immunology, and the Department of Nephrology, Normandie Université, UNICAEN, Centre Hospitalier Universitaire (CHU) de Caen Normandie, Caen; Department of Infectious Diseases, CH Mémorial, Saint-Lô, France.
S. Deshayes, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; N. Martin Silva, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; F. Grandhomme, MD, Department of Biochemistry, Normandie Université, UNICAEN, CHU de Caen Normandie; K. Khoy, PharmD, PhD, Department of Immunology, Normandie Université, UNICAEN, CHU de Caen Normandie; D. Mariotte, PharmD, Department of Immunology, Normandie Université, UNICAEN, CHU de Caen Normandie; J. Boutemy, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; G. Maigné, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; C. Brière-Bellier, MD, Department of Infectious Diseases, CH Mémorial; C. Delmas, MD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; B. Bienvenu, MD, PhD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; T. Lobbedez, MD, PhD, Department of Nephrology, Normandie Université, UNICAEN, CHU de Caen Normandie; H. de Boysson, MD, MSc, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie; A. Aouba, MD, PhD, Department of Internal Medicine, Normandie Université, UNICAEN, CHU de Caen Normandie.
Address correspondence to Prof. A. Aouba, Department of Internal Medicine and Clinical Immunology, Normandie Université, UNICAEN, CHU de Caen Normandie, Avenue de la Côte de Nacre, 14000 Caen, France. E-mail: aouba-a@chu-caen.fr.
Accepted for publication November 12, 2018.
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In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Clinical Effect of Alpha-1 Antitrypsin Deficiency in Antineutrophil Cytoplasmic Antibody–associated Vasculitis: Results from a French Retrospective Monocentric Cohort
Samuel Deshayes, Nicolas Martin Silva, Frédérique Grandhomme, Kathy Khoy, Delphine Mariotte, Jonathan Boutemy, Gwénola Maigné, Claire Brière-Bellier, Claire Delmas, Boris Bienvenu, Thierry Lobbedez, Hubert de Boysson, Achille Aouba
The Journal of Rheumatology Mar 2019, jrheum.180591; DOI: 10.3899/jrheum.180591
Clinical Effect of Alpha-1 Antitrypsin Deficiency in Antineutrophil Cytoplasmic Antibody–associated Vasculitis: Results from a French Retrospective Monocentric Cohort
Samuel Deshayes, Nicolas Martin Silva, Frédérique Grandhomme, Kathy Khoy, Delphine Mariotte, Jonathan Boutemy, Gwénola Maigné, Claire Brière-Bellier, Claire Delmas, Boris Bienvenu, Thierry Lobbedez, Hubert de Boysson, Achille Aouba
The Journal of Rheumatology Mar 2019, jrheum.180591; DOI: 10.3899/jrheum.180591