Research ArticleArticle
Precipitation of Soluble Uric Acid Is Necessary for In Vitro Activation of the NLRP3 Inflammasome in Primary Human Monocytes
Ben M. Alberts, James S. Barber, Sandra M. Sacre, Kevin A. Davies, Pietro Ghezzi and Lisa M. Mullen
The Journal of Rheumatology March 2019, jrheum.180855; DOI: https://doi.org/10.3899/jrheum.180855
Ben M. Alberts
From the Brighton and Sussex Medical School, University of Sussex, Brighton, UK. Supported by Brighton and Sussex Medical School. B.M. Alberts, BSc, PhD Student, Brighton and Sussex Medical School, University of Sussex; J.S. Barber, BM BS, Brighton and Sussex Medical School, University of Sussex; S.M. Sacre, PhD, Senior Lecturer in Molecular Cell Biology, Brighton and Sussex Medical School, University of Sussex; K.A. Davies, MD, MA, MB BS, Foundation Professor of Medicine, Head of the Department of Clinical and Experimental Medicine, Brighton and Sussex Medical School, University of Sussex; P. Ghezzi, PhD, RM Phillips Chair in Experimental Medicine, Brighton and Sussex Medical School, University of Sussex; L.M. Mullen, PhD, Lecturer in Biochemistry, Brighton and Sussex Medical School, University of Sussex. Address correspondence to L.M. Mullen, Medical Research Building, University of Sussex, Brighton BN1 9PS, UK. E-mail: L.Mullen@bsms.ac.uk. Accepted for publication December 20, 2018.
James S. Barber
From the Brighton and Sussex Medical School, University of Sussex, Brighton, UK. Supported by Brighton and Sussex Medical School. B.M. Alberts, BSc, PhD Student, Brighton and Sussex Medical School, University of Sussex; J.S. Barber, BM BS, Brighton and Sussex Medical School, University of Sussex; S.M. Sacre, PhD, Senior Lecturer in Molecular Cell Biology, Brighton and Sussex Medical School, University of Sussex; K.A. Davies, MD, MA, MB BS, Foundation Professor of Medicine, Head of the Department of Clinical and Experimental Medicine, Brighton and Sussex Medical School, University of Sussex; P. Ghezzi, PhD, RM Phillips Chair in Experimental Medicine, Brighton and Sussex Medical School, University of Sussex; L.M. Mullen, PhD, Lecturer in Biochemistry, Brighton and Sussex Medical School, University of Sussex. Address correspondence to L.M. Mullen, Medical Research Building, University of Sussex, Brighton BN1 9PS, UK. E-mail: L.Mullen@bsms.ac.uk. Accepted for publication December 20, 2018.
Sandra M. Sacre
From the Brighton and Sussex Medical School, University of Sussex, Brighton, UK. Supported by Brighton and Sussex Medical School. B.M. Alberts, BSc, PhD Student, Brighton and Sussex Medical School, University of Sussex; J.S. Barber, BM BS, Brighton and Sussex Medical School, University of Sussex; S.M. Sacre, PhD, Senior Lecturer in Molecular Cell Biology, Brighton and Sussex Medical School, University of Sussex; K.A. Davies, MD, MA, MB BS, Foundation Professor of Medicine, Head of the Department of Clinical and Experimental Medicine, Brighton and Sussex Medical School, University of Sussex; P. Ghezzi, PhD, RM Phillips Chair in Experimental Medicine, Brighton and Sussex Medical School, University of Sussex; L.M. Mullen, PhD, Lecturer in Biochemistry, Brighton and Sussex Medical School, University of Sussex. Address correspondence to L.M. Mullen, Medical Research Building, University of Sussex, Brighton BN1 9PS, UK. E-mail: L.Mullen@bsms.ac.uk. Accepted for publication December 20, 2018.
Kevin A. Davies
From the Brighton and Sussex Medical School, University of Sussex, Brighton, UK. Supported by Brighton and Sussex Medical School. B.M. Alberts, BSc, PhD Student, Brighton and Sussex Medical School, University of Sussex; J.S. Barber, BM BS, Brighton and Sussex Medical School, University of Sussex; S.M. Sacre, PhD, Senior Lecturer in Molecular Cell Biology, Brighton and Sussex Medical School, University of Sussex; K.A. Davies, MD, MA, MB BS, Foundation Professor of Medicine, Head of the Department of Clinical and Experimental Medicine, Brighton and Sussex Medical School, University of Sussex; P. Ghezzi, PhD, RM Phillips Chair in Experimental Medicine, Brighton and Sussex Medical School, University of Sussex; L.M. Mullen, PhD, Lecturer in Biochemistry, Brighton and Sussex Medical School, University of Sussex. Address correspondence to L.M. Mullen, Medical Research Building, University of Sussex, Brighton BN1 9PS, UK. E-mail: L.Mullen@bsms.ac.uk. Accepted for publication December 20, 2018.
Pietro Ghezzi
From the Brighton and Sussex Medical School, University of Sussex, Brighton, UK. Supported by Brighton and Sussex Medical School. B.M. Alberts, BSc, PhD Student, Brighton and Sussex Medical School, University of Sussex; J.S. Barber, BM BS, Brighton and Sussex Medical School, University of Sussex; S.M. Sacre, PhD, Senior Lecturer in Molecular Cell Biology, Brighton and Sussex Medical School, University of Sussex; K.A. Davies, MD, MA, MB BS, Foundation Professor of Medicine, Head of the Department of Clinical and Experimental Medicine, Brighton and Sussex Medical School, University of Sussex; P. Ghezzi, PhD, RM Phillips Chair in Experimental Medicine, Brighton and Sussex Medical School, University of Sussex; L.M. Mullen, PhD, Lecturer in Biochemistry, Brighton and Sussex Medical School, University of Sussex. Address correspondence to L.M. Mullen, Medical Research Building, University of Sussex, Brighton BN1 9PS, UK. E-mail: L.Mullen@bsms.ac.uk. Accepted for publication December 20, 2018.
Lisa M. Mullen
From the Brighton and Sussex Medical School, University of Sussex, Brighton, UK. Supported by Brighton and Sussex Medical School. B.M. Alberts, BSc, PhD Student, Brighton and Sussex Medical School, University of Sussex; J.S. Barber, BM BS, Brighton and Sussex Medical School, University of Sussex; S.M. Sacre, PhD, Senior Lecturer in Molecular Cell Biology, Brighton and Sussex Medical School, University of Sussex; K.A. Davies, MD, MA, MB BS, Foundation Professor of Medicine, Head of the Department of Clinical and Experimental Medicine, Brighton and Sussex Medical School, University of Sussex; P. Ghezzi, PhD, RM Phillips Chair in Experimental Medicine, Brighton and Sussex Medical School, University of Sussex; L.M. Mullen, PhD, Lecturer in Biochemistry, Brighton and Sussex Medical School, University of Sussex. Address correspondence to L.M. Mullen, Medical Research Building, University of Sussex, Brighton BN1 9PS, UK. E-mail: L.Mullen@bsms.ac.uk. Accepted for publication December 20, 2018.
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In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Precipitation of Soluble Uric Acid Is Necessary for In Vitro Activation of the NLRP3 Inflammasome in Primary Human Monocytes
Ben M. Alberts, James S. Barber, Sandra M. Sacre, Kevin A. Davies, Pietro Ghezzi, Lisa M. Mullen
The Journal of Rheumatology Mar 2019, jrheum.180855; DOI: 10.3899/jrheum.180855
Precipitation of Soluble Uric Acid Is Necessary for In Vitro Activation of the NLRP3 Inflammasome in Primary Human Monocytes
Ben M. Alberts, James S. Barber, Sandra M. Sacre, Kevin A. Davies, Pietro Ghezzi, Lisa M. Mullen
The Journal of Rheumatology Mar 2019, jrheum.180855; DOI: 10.3899/jrheum.180855