Research ArticleArticle
Open Access
Neutropenia During Tocilizumab Treatment Is Not Associated with Infection Risk in Systemic or Polyarticular-course Juvenile Idiopathic Arthritis
Manuela Pardeo, Jianmei Wang, Nicolino Ruperto, Ekaterina Alexeeva, Vyacheslav Chasnyk, Rayfel Schneider, Gerd Horneff, Hans-Iko Huppertz, Kirsten Minden, Karen Onel, Lawrence Zemel, Alan Martin, Isabelle Koné-Paut, Antigoni Siamopoulou-Mavridou, Clovis A. Silva, Benjamin Porter-Brown, Kamal N. Bharucha, Hermine I. Brunner and Fabrizio De Benedetti for the Paediatric Rheumatology International Trials Organisation (PRINTO) and the Pediatric Rheumatology Collaborative Study Group (PRCSG)
The Journal of Rheumatology March 2019, jrheum.180795; DOI: https://doi.org/10.3899/jrheum.180795
Manuela Pardeo
From the Institute for Research and Health Care (IRCCS) Ospedale Pediatrico Bambino Gesù, Division of Rheumatology, Rome, Italy; Roche Products Ltd., Welwyn Garden City, UK; IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO, Genoa, Italy; Federal State Autonomous Institution National Medical Research Center of Children’s Health of the Ministry of Health of the Russian Federation, Department of Rheumatology, and Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation, Department of Pediatrics and Pediatric Rheumatology, Moscow; Saint-Petersburg State Pediatric Medical University, Department of Hospital Pediatrics, St. Petersburg, Russia; Hospital for Sick Children, University of Toronto, Department of Pediatrics, Division of Rheumatology, Toronto, Ontario, Canada; Asklepios Klinik Sankt Augustin, Centre for General Pediatrics and Neonatology, Sankt Augustin, and University Hospital of Cologne, Cologne; Prof. Hess Children’s Hospital and Pediatric Intensive Care Medicine, Bremen; German Rheumatism Research Centre Berlin, and Charité University Medicine, Department of Rheumatology and Clinical Immunology, Berlin, Germany; Hospital for Special Surgery, Division of Pediatric Rheumatology, New York, New York; Connecticut Children’s Medical Center, Pediatric Rheumatology, Hartford, Connecticut; Tulsa Bone and Joint Associates, Tulsa, Oklahoma; Genentech, South San Francisco, California; University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Division of Rheumatology, Department of Pediatrics, PRCSG Coordinating Center, Cincinnati, Ohio, USA; National Referral Centre of Auto-Inflammatory Diseases, CEREMAIA, Centre Hospitalier Universitaire (CHU) de Bicere, Department of Pediatric Rheumatology, AP-HP, University of Paris Sud, Le Kremlin Bicêtre, France; University Hospital of Ioannina, Unit of Paediatric Rheumatology, Paediatric Clinic, Ioannina, Greece; Children’s Institute, Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo (HCFMUSP), Pediatric Rheumatology Unit, Sao Paulo, Brazil. The study was sponsored by F. Hoffmann-La Roche Ltd., which manufactures tocilizumab. Support for third-party writing assistance was provided by Sara Duggan, PhD, of ApotheCom and was funded by F. Hoffmann-La Roche Ltd. J. Wang is an employee of F. Hoffmann-La Roche Ltd. N. Ruperto is a consultant/speaker for F. Hoffmann-La Roche Ltd. E. Alexeeva is a consultant/speaker for F. Hoffmann-La Roche Ltd. K. Minden is a consultant/speaker or receives honoraria from F. Hoffmann-La Roche Ltd. I. Koné-Paut is a consultant to F. Hoffmann-La Roche Ltd. B. Porter-Brown is an employee of and owns stock in F. Hoffmann-La Roche Ltd. K. Bharucha owns stock in F. Hoffmann-La Roche Ltd. H.I. Brunner is a consultant/speaker or receives honoraria from F. Hoffmann-La Roche Ltd. F. De Benedetti is a consultant/speaker or receives honoraria from F. Hoffmann-La Roche Ltd. M. Pardeo, MD, IRCCS Ospedale Pediatrico Bambino Gesù, Division of Rheumatology; J. Wang, PhD, Roche Products Ltd.; N. Ruperto, MD, MPH, IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO; E. Alexeeva, MD, PhD, Professor, Federal State Autonomous Institution National Medical Research Center of Children’s Health of the Ministry of Health of the Russian Federation, Department of Rheumatology, and Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation, Department of Pediatrics and Pediatric Rheumatology; V. Chasnyk, MD, Professor, Saint-Petersburg State Pediatric Medical University, Department of Hospital Pediatrics; R. Schneider, MBBCh, Hospital for Sick Children, University of Toronto, Department of Pediatrics, Division of Rheumatology; G. Horneff, MD, Professor, Asklepios Klinik Sankt Augustin, Centre for General Pediatrics and Neonatology, Sankt Augustin, and University Hospital of Cologne; H.I. Huppertz, MD, Professor, Prof. Hess Children’s Hospital and Pediatric Intensive Care Medicine; K. Minden, MD, German Rheumatism Research Centre Berlin, and Charité University Medicine, Department of Rheumatology and Clinical Immunology; K. Onel, MD, Professor, Hospital for Special Surgery, Division of Pediatric Rheumatology; L. Zemel, MD, Connecticut Children’s Medical Center, Pediatric Rheumatology; A. Martin, MD, Tulsa Bone and Joint Associates; I. Koné-Paut, MD, National Referral Centre of Auto-Inflammatory Diseases, CEREMAIA, CHU de Bicere, Department of Pediatric Rheumatology, AP-HP, University of Paris Sud; A. Siamopoulou-Mavridou, MD, Professor, University Hospital of Ioannina, Unit of Paediatric Rheumatology, Paediatric Clinic; C.A. Silva, MD, PhD, Associate Professor, Children’s Institute, HCFMUSP, Pediatric Rheumatology Unit; B. Porter-Brown, MBBS, DPM, MFPM, Roche Products Ltd.; K.N. Bharucha, PhD, MD, Genentech (affiliation at time of the study); H.I. Brunner, MD, MSc, University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Division of Rheumatology, Department of Pediatrics, PRCSG Coordinating Center; F. De Benedetti, MD, PhD, IRCCS Ospedale Pediatrico Bambino Gesù, Division of Rheumatology. M. Pardeo and J. Wang contributed equally to the study. Address correspondence to Dr. F. De Benedetti, IRCCS Ospedale Pediatrico Bambino Gesù, Piazza S. Onofrio 4, 00165 Rome, Italy. E-mail: fabrizio.debenedetti@opbg.net. Full Release Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication December 19, 2018.
Jianmei Wang
From the Institute for Research and Health Care (IRCCS) Ospedale Pediatrico Bambino Gesù, Division of Rheumatology, Rome, Italy; Roche Products Ltd., Welwyn Garden City, UK; IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO, Genoa, Italy; Federal State Autonomous Institution National Medical Research Center of Children’s Health of the Ministry of Health of the Russian Federation, Department of Rheumatology, and Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation, Department of Pediatrics and Pediatric Rheumatology, Moscow; Saint-Petersburg State Pediatric Medical University, Department of Hospital Pediatrics, St. Petersburg, Russia; Hospital for Sick Children, University of Toronto, Department of Pediatrics, Division of Rheumatology, Toronto, Ontario, Canada; Asklepios Klinik Sankt Augustin, Centre for General Pediatrics and Neonatology, Sankt Augustin, and University Hospital of Cologne, Cologne; Prof. Hess Children’s Hospital and Pediatric Intensive Care Medicine, Bremen; German Rheumatism Research Centre Berlin, and Charité University Medicine, Department of Rheumatology and Clinical Immunology, Berlin, Germany; Hospital for Special Surgery, Division of Pediatric Rheumatology, New York, New York; Connecticut Children’s Medical Center, Pediatric Rheumatology, Hartford, Connecticut; Tulsa Bone and Joint Associates, Tulsa, Oklahoma; Genentech, South San Francisco, California; University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Division of Rheumatology, Department of Pediatrics, PRCSG Coordinating Center, Cincinnati, Ohio, USA; National Referral Centre of Auto-Inflammatory Diseases, CEREMAIA, Centre Hospitalier Universitaire (CHU) de Bicere, Department of Pediatric Rheumatology, AP-HP, University of Paris Sud, Le Kremlin Bicêtre, France; University Hospital of Ioannina, Unit of Paediatric Rheumatology, Paediatric Clinic, Ioannina, Greece; Children’s Institute, Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo (HCFMUSP), Pediatric Rheumatology Unit, Sao Paulo, Brazil. The study was sponsored by F. Hoffmann-La Roche Ltd., which manufactures tocilizumab. Support for third-party writing assistance was provided by Sara Duggan, PhD, of ApotheCom and was funded by F. Hoffmann-La Roche Ltd. J. Wang is an employee of F. Hoffmann-La Roche Ltd. N. Ruperto is a consultant/speaker for F. Hoffmann-La Roche Ltd. E. Alexeeva is a consultant/speaker for F. Hoffmann-La Roche Ltd. K. Minden is a consultant/speaker or receives honoraria from F. Hoffmann-La Roche Ltd. I. Koné-Paut is a consultant to F. Hoffmann-La Roche Ltd. B. Porter-Brown is an employee of and owns stock in F. Hoffmann-La Roche Ltd. K. Bharucha owns stock in F. Hoffmann-La Roche Ltd. H.I. Brunner is a consultant/speaker or receives honoraria from F. Hoffmann-La Roche Ltd. F. De Benedetti is a consultant/speaker or receives honoraria from F. Hoffmann-La Roche Ltd. M. Pardeo, MD, IRCCS Ospedale Pediatrico Bambino Gesù, Division of Rheumatology; J. Wang, PhD, Roche Products Ltd.; N. Ruperto, MD, MPH, IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO; E. Alexeeva, MD, PhD, Professor, Federal State Autonomous Institution National Medical Research Center of Children’s Health of the Ministry of Health of the Russian Federation, Department of Rheumatology, and Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation, Department of Pediatrics and Pediatric Rheumatology; V. Chasnyk, MD, Professor, Saint-Petersburg State Pediatric Medical University, Department of Hospital Pediatrics; R. Schneider, MBBCh, Hospital for Sick Children, University of Toronto, Department of Pediatrics, Division of Rheumatology; G. Horneff, MD, Professor, Asklepios Klinik Sankt Augustin, Centre for General Pediatrics and Neonatology, Sankt Augustin, and University Hospital of Cologne; H.I. Huppertz, MD, Professor, Prof. Hess Children’s Hospital and Pediatric Intensive Care Medicine; K. Minden, MD, German Rheumatism Research Centre Berlin, and Charité University Medicine, Department of Rheumatology and Clinical Immunology; K. Onel, MD, Professor, Hospital for Special Surgery, Division of Pediatric Rheumatology; L. Zemel, MD, Connecticut Children’s Medical Center, Pediatric Rheumatology; A. Martin, MD, Tulsa Bone and Joint Associates; I. Koné-Paut, MD, National Referral Centre of Auto-Inflammatory Diseases, CEREMAIA, CHU de Bicere, Department of Pediatric Rheumatology, AP-HP, University of Paris Sud; A. Siamopoulou-Mavridou, MD, Professor, University Hospital of Ioannina, Unit of Paediatric Rheumatology, Paediatric Clinic; C.A. Silva, MD, PhD, Associate Professor, Children’s Institute, HCFMUSP, Pediatric Rheumatology Unit; B. Porter-Brown, MBBS, DPM, MFPM, Roche Products Ltd.; K.N. Bharucha, PhD, MD, Genentech (affiliation at time of the study); H.I. Brunner, MD, MSc, University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Division of Rheumatology, Department of Pediatrics, PRCSG Coordinating Center; F. De Benedetti, MD, PhD, IRCCS Ospedale Pediatrico Bambino Gesù, Division of Rheumatology. M. Pardeo and J. Wang contributed equally to the study. Address correspondence to Dr. F. De Benedetti, IRCCS Ospedale Pediatrico Bambino Gesù, Piazza S. Onofrio 4, 00165 Rome, Italy. E-mail: fabrizio.debenedetti@opbg.net. Full Release Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication December 19, 2018.
Nicolino Ruperto
From the Institute for Research and Health Care (IRCCS) Ospedale Pediatrico Bambino Gesù, Division of Rheumatology, Rome, Italy; Roche Products Ltd., Welwyn Garden City, UK; IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO, Genoa, Italy; Federal State Autonomous Institution National Medical Research Center of Children’s Health of the Ministry of Health of the Russian Federation, Department of Rheumatology, and Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation, Department of Pediatrics and Pediatric Rheumatology, Moscow; Saint-Petersburg State Pediatric Medical University, Department of Hospital Pediatrics, St. Petersburg, Russia; Hospital for Sick Children, University of Toronto, Department of Pediatrics, Division of Rheumatology, Toronto, Ontario, Canada; Asklepios Klinik Sankt Augustin, Centre for General Pediatrics and Neonatology, Sankt Augustin, and University Hospital of Cologne, Cologne; Prof. Hess Children’s Hospital and Pediatric Intensive Care Medicine, Bremen; German Rheumatism Research Centre Berlin, and Charité University Medicine, Department of Rheumatology and Clinical Immunology, Berlin, Germany; Hospital for Special Surgery, Division of Pediatric Rheumatology, New York, New York; Connecticut Children’s Medical Center, Pediatric Rheumatology, Hartford, Connecticut; Tulsa Bone and Joint Associates, Tulsa, Oklahoma; Genentech, South San Francisco, California; University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Division of Rheumatology, Department of Pediatrics, PRCSG Coordinating Center, Cincinnati, Ohio, USA; National Referral Centre of Auto-Inflammatory Diseases, CEREMAIA, Centre Hospitalier Universitaire (CHU) de Bicere, Department of Pediatric Rheumatology, AP-HP, University of Paris Sud, Le Kremlin Bicêtre, France; University Hospital of Ioannina, Unit of Paediatric Rheumatology, Paediatric Clinic, Ioannina, Greece; Children’s Institute, Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo (HCFMUSP), Pediatric Rheumatology Unit, Sao Paulo, Brazil. The study was sponsored by F. Hoffmann-La Roche Ltd., which manufactures tocilizumab. Support for third-party writing assistance was provided by Sara Duggan, PhD, of ApotheCom and was funded by F. Hoffmann-La Roche Ltd. J. Wang is an employee of F. Hoffmann-La Roche Ltd. N. Ruperto is a consultant/speaker for F. Hoffmann-La Roche Ltd. E. Alexeeva is a consultant/speaker for F. Hoffmann-La Roche Ltd. K. Minden is a consultant/speaker or receives honoraria from F. Hoffmann-La Roche Ltd. I. Koné-Paut is a consultant to F. Hoffmann-La Roche Ltd. B. Porter-Brown is an employee of and owns stock in F. Hoffmann-La Roche Ltd. K. Bharucha owns stock in F. Hoffmann-La Roche Ltd. H.I. Brunner is a consultant/speaker or receives honoraria from F. Hoffmann-La Roche Ltd. F. De Benedetti is a consultant/speaker or receives honoraria from F. Hoffmann-La Roche Ltd. M. Pardeo, MD, IRCCS Ospedale Pediatrico Bambino Gesù, Division of Rheumatology; J. Wang, PhD, Roche Products Ltd.; N. Ruperto, MD, MPH, IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO; E. Alexeeva, MD, PhD, Professor, Federal State Autonomous Institution National Medical Research Center of Children’s Health of the Ministry of Health of the Russian Federation, Department of Rheumatology, and Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation, Department of Pediatrics and Pediatric Rheumatology; V. Chasnyk, MD, Professor, Saint-Petersburg State Pediatric Medical University, Department of Hospital Pediatrics; R. Schneider, MBBCh, Hospital for Sick Children, University of Toronto, Department of Pediatrics, Division of Rheumatology; G. Horneff, MD, Professor, Asklepios Klinik Sankt Augustin, Centre for General Pediatrics and Neonatology, Sankt Augustin, and University Hospital of Cologne; H.I. Huppertz, MD, Professor, Prof. Hess Children’s Hospital and Pediatric Intensive Care Medicine; K. Minden, MD, German Rheumatism Research Centre Berlin, and Charité University Medicine, Department of Rheumatology and Clinical Immunology; K. Onel, MD, Professor, Hospital for Special Surgery, Division of Pediatric Rheumatology; L. Zemel, MD, Connecticut Children’s Medical Center, Pediatric Rheumatology; A. Martin, MD, Tulsa Bone and Joint Associates; I. Koné-Paut, MD, National Referral Centre of Auto-Inflammatory Diseases, CEREMAIA, CHU de Bicere, Department of Pediatric Rheumatology, AP-HP, University of Paris Sud; A. Siamopoulou-Mavridou, MD, Professor, University Hospital of Ioannina, Unit of Paediatric Rheumatology, Paediatric Clinic; C.A. Silva, MD, PhD, Associate Professor, Children’s Institute, HCFMUSP, Pediatric Rheumatology Unit; B. Porter-Brown, MBBS, DPM, MFPM, Roche Products Ltd.; K.N. Bharucha, PhD, MD, Genentech (affiliation at time of the study); H.I. Brunner, MD, MSc, University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Division of Rheumatology, Department of Pediatrics, PRCSG Coordinating Center; F. De Benedetti, MD, PhD, IRCCS Ospedale Pediatrico Bambino Gesù, Division of Rheumatology. M. Pardeo and J. Wang contributed equally to the study. Address correspondence to Dr. F. De Benedetti, IRCCS Ospedale Pediatrico Bambino Gesù, Piazza S. Onofrio 4, 00165 Rome, Italy. E-mail: fabrizio.debenedetti@opbg.net. Full Release Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication December 19, 2018.
Ekaterina Alexeeva
From the Institute for Research and Health Care (IRCCS) Ospedale Pediatrico Bambino Gesù, Division of Rheumatology, Rome, Italy; Roche Products Ltd., Welwyn Garden City, UK; IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO, Genoa, Italy; Federal State Autonomous Institution National Medical Research Center of Children’s Health of the Ministry of Health of the Russian Federation, Department of Rheumatology, and Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation, Department of Pediatrics and Pediatric Rheumatology, Moscow; Saint-Petersburg State Pediatric Medical University, Department of Hospital Pediatrics, St. Petersburg, Russia; Hospital for Sick Children, University of Toronto, Department of Pediatrics, Division of Rheumatology, Toronto, Ontario, Canada; Asklepios Klinik Sankt Augustin, Centre for General Pediatrics and Neonatology, Sankt Augustin, and University Hospital of Cologne, Cologne; Prof. Hess Children’s Hospital and Pediatric Intensive Care Medicine, Bremen; German Rheumatism Research Centre Berlin, and Charité University Medicine, Department of Rheumatology and Clinical Immunology, Berlin, Germany; Hospital for Special Surgery, Division of Pediatric Rheumatology, New York, New York; Connecticut Children’s Medical Center, Pediatric Rheumatology, Hartford, Connecticut; Tulsa Bone and Joint Associates, Tulsa, Oklahoma; Genentech, South San Francisco, California; University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Division of Rheumatology, Department of Pediatrics, PRCSG Coordinating Center, Cincinnati, Ohio, USA; National Referral Centre of Auto-Inflammatory Diseases, CEREMAIA, Centre Hospitalier Universitaire (CHU) de Bicere, Department of Pediatric Rheumatology, AP-HP, University of Paris Sud, Le Kremlin Bicêtre, France; University Hospital of Ioannina, Unit of Paediatric Rheumatology, Paediatric Clinic, Ioannina, Greece; Children’s Institute, Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo (HCFMUSP), Pediatric Rheumatology Unit, Sao Paulo, Brazil. The study was sponsored by F. Hoffmann-La Roche Ltd., which manufactures tocilizumab. Support for third-party writing assistance was provided by Sara Duggan, PhD, of ApotheCom and was funded by F. Hoffmann-La Roche Ltd. J. Wang is an employee of F. Hoffmann-La Roche Ltd. N. Ruperto is a consultant/speaker for F. Hoffmann-La Roche Ltd. E. Alexeeva is a consultant/speaker for F. Hoffmann-La Roche Ltd. K. Minden is a consultant/speaker or receives honoraria from F. Hoffmann-La Roche Ltd. I. Koné-Paut is a consultant to F. Hoffmann-La Roche Ltd. B. Porter-Brown is an employee of and owns stock in F. Hoffmann-La Roche Ltd. K. Bharucha owns stock in F. Hoffmann-La Roche Ltd. H.I. Brunner is a consultant/speaker or receives honoraria from F. Hoffmann-La Roche Ltd. F. De Benedetti is a consultant/speaker or receives honoraria from F. Hoffmann-La Roche Ltd. M. Pardeo, MD, IRCCS Ospedale Pediatrico Bambino Gesù, Division of Rheumatology; J. Wang, PhD, Roche Products Ltd.; N. Ruperto, MD, MPH, IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO; E. Alexeeva, MD, PhD, Professor, Federal State Autonomous Institution National Medical Research Center of Children’s Health of the Ministry of Health of the Russian Federation, Department of Rheumatology, and Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation, Department of Pediatrics and Pediatric Rheumatology; V. Chasnyk, MD, Professor, Saint-Petersburg State Pediatric Medical University, Department of Hospital Pediatrics; R. Schneider, MBBCh, Hospital for Sick Children, University of Toronto, Department of Pediatrics, Division of Rheumatology; G. Horneff, MD, Professor, Asklepios Klinik Sankt Augustin, Centre for General Pediatrics and Neonatology, Sankt Augustin, and University Hospital of Cologne; H.I. Huppertz, MD, Professor, Prof. Hess Children’s Hospital and Pediatric Intensive Care Medicine; K. Minden, MD, German Rheumatism Research Centre Berlin, and Charité University Medicine, Department of Rheumatology and Clinical Immunology; K. Onel, MD, Professor, Hospital for Special Surgery, Division of Pediatric Rheumatology; L. Zemel, MD, Connecticut Children’s Medical Center, Pediatric Rheumatology; A. Martin, MD, Tulsa Bone and Joint Associates; I. Koné-Paut, MD, National Referral Centre of Auto-Inflammatory Diseases, CEREMAIA, CHU de Bicere, Department of Pediatric Rheumatology, AP-HP, University of Paris Sud; A. Siamopoulou-Mavridou, MD, Professor, University Hospital of Ioannina, Unit of Paediatric Rheumatology, Paediatric Clinic; C.A. Silva, MD, PhD, Associate Professor, Children’s Institute, HCFMUSP, Pediatric Rheumatology Unit; B. Porter-Brown, MBBS, DPM, MFPM, Roche Products Ltd.; K.N. Bharucha, PhD, MD, Genentech (affiliation at time of the study); H.I. Brunner, MD, MSc, University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Division of Rheumatology, Department of Pediatrics, PRCSG Coordinating Center; F. De Benedetti, MD, PhD, IRCCS Ospedale Pediatrico Bambino Gesù, Division of Rheumatology. M. Pardeo and J. Wang contributed equally to the study. Address correspondence to Dr. F. De Benedetti, IRCCS Ospedale Pediatrico Bambino Gesù, Piazza S. Onofrio 4, 00165 Rome, Italy. E-mail: fabrizio.debenedetti@opbg.net. Full Release Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication December 19, 2018.
Vyacheslav Chasnyk
From the Institute for Research and Health Care (IRCCS) Ospedale Pediatrico Bambino Gesù, Division of Rheumatology, Rome, Italy; Roche Products Ltd., Welwyn Garden City, UK; IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO, Genoa, Italy; Federal State Autonomous Institution National Medical Research Center of Children’s Health of the Ministry of Health of the Russian Federation, Department of Rheumatology, and Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation, Department of Pediatrics and Pediatric Rheumatology, Moscow; Saint-Petersburg State Pediatric Medical University, Department of Hospital Pediatrics, St. Petersburg, Russia; Hospital for Sick Children, University of Toronto, Department of Pediatrics, Division of Rheumatology, Toronto, Ontario, Canada; Asklepios Klinik Sankt Augustin, Centre for General Pediatrics and Neonatology, Sankt Augustin, and University Hospital of Cologne, Cologne; Prof. Hess Children’s Hospital and Pediatric Intensive Care Medicine, Bremen; German Rheumatism Research Centre Berlin, and Charité University Medicine, Department of Rheumatology and Clinical Immunology, Berlin, Germany; Hospital for Special Surgery, Division of Pediatric Rheumatology, New York, New York; Connecticut Children’s Medical Center, Pediatric Rheumatology, Hartford, Connecticut; Tulsa Bone and Joint Associates, Tulsa, Oklahoma; Genentech, South San Francisco, California; University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Division of Rheumatology, Department of Pediatrics, PRCSG Coordinating Center, Cincinnati, Ohio, USA; National Referral Centre of Auto-Inflammatory Diseases, CEREMAIA, Centre Hospitalier Universitaire (CHU) de Bicere, Department of Pediatric Rheumatology, AP-HP, University of Paris Sud, Le Kremlin Bicêtre, France; University Hospital of Ioannina, Unit of Paediatric Rheumatology, Paediatric Clinic, Ioannina, Greece; Children’s Institute, Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo (HCFMUSP), Pediatric Rheumatology Unit, Sao Paulo, Brazil. The study was sponsored by F. Hoffmann-La Roche Ltd., which manufactures tocilizumab. Support for third-party writing assistance was provided by Sara Duggan, PhD, of ApotheCom and was funded by F. Hoffmann-La Roche Ltd. J. Wang is an employee of F. Hoffmann-La Roche Ltd. N. Ruperto is a consultant/speaker for F. Hoffmann-La Roche Ltd. E. Alexeeva is a consultant/speaker for F. Hoffmann-La Roche Ltd. K. Minden is a consultant/speaker or receives honoraria from F. Hoffmann-La Roche Ltd. I. Koné-Paut is a consultant to F. Hoffmann-La Roche Ltd. B. Porter-Brown is an employee of and owns stock in F. Hoffmann-La Roche Ltd. K. Bharucha owns stock in F. Hoffmann-La Roche Ltd. H.I. Brunner is a consultant/speaker or receives honoraria from F. Hoffmann-La Roche Ltd. F. De Benedetti is a consultant/speaker or receives honoraria from F. Hoffmann-La Roche Ltd. M. Pardeo, MD, IRCCS Ospedale Pediatrico Bambino Gesù, Division of Rheumatology; J. Wang, PhD, Roche Products Ltd.; N. Ruperto, MD, MPH, IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO; E. Alexeeva, MD, PhD, Professor, Federal State Autonomous Institution National Medical Research Center of Children’s Health of the Ministry of Health of the Russian Federation, Department of Rheumatology, and Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation, Department of Pediatrics and Pediatric Rheumatology; V. Chasnyk, MD, Professor, Saint-Petersburg State Pediatric Medical University, Department of Hospital Pediatrics; R. Schneider, MBBCh, Hospital for Sick Children, University of Toronto, Department of Pediatrics, Division of Rheumatology; G. Horneff, MD, Professor, Asklepios Klinik Sankt Augustin, Centre for General Pediatrics and Neonatology, Sankt Augustin, and University Hospital of Cologne; H.I. Huppertz, MD, Professor, Prof. Hess Children’s Hospital and Pediatric Intensive Care Medicine; K. Minden, MD, German Rheumatism Research Centre Berlin, and Charité University Medicine, Department of Rheumatology and Clinical Immunology; K. Onel, MD, Professor, Hospital for Special Surgery, Division of Pediatric Rheumatology; L. Zemel, MD, Connecticut Children’s Medical Center, Pediatric Rheumatology; A. Martin, MD, Tulsa Bone and Joint Associates; I. Koné-Paut, MD, National Referral Centre of Auto-Inflammatory Diseases, CEREMAIA, CHU de Bicere, Department of Pediatric Rheumatology, AP-HP, University of Paris Sud; A. Siamopoulou-Mavridou, MD, Professor, University Hospital of Ioannina, Unit of Paediatric Rheumatology, Paediatric Clinic; C.A. Silva, MD, PhD, Associate Professor, Children’s Institute, HCFMUSP, Pediatric Rheumatology Unit; B. Porter-Brown, MBBS, DPM, MFPM, Roche Products Ltd.; K.N. Bharucha, PhD, MD, Genentech (affiliation at time of the study); H.I. Brunner, MD, MSc, University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Division of Rheumatology, Department of Pediatrics, PRCSG Coordinating Center; F. De Benedetti, MD, PhD, IRCCS Ospedale Pediatrico Bambino Gesù, Division of Rheumatology. M. Pardeo and J. Wang contributed equally to the study. Address correspondence to Dr. F. De Benedetti, IRCCS Ospedale Pediatrico Bambino Gesù, Piazza S. Onofrio 4, 00165 Rome, Italy. E-mail: fabrizio.debenedetti@opbg.net. Full Release Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication December 19, 2018.
Rayfel Schneider
From the Institute for Research and Health Care (IRCCS) Ospedale Pediatrico Bambino Gesù, Division of Rheumatology, Rome, Italy; Roche Products Ltd., Welwyn Garden City, UK; IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO, Genoa, Italy; Federal State Autonomous Institution National Medical Research Center of Children’s Health of the Ministry of Health of the Russian Federation, Department of Rheumatology, and Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation, Department of Pediatrics and Pediatric Rheumatology, Moscow; Saint-Petersburg State Pediatric Medical University, Department of Hospital Pediatrics, St. Petersburg, Russia; Hospital for Sick Children, University of Toronto, Department of Pediatrics, Division of Rheumatology, Toronto, Ontario, Canada; Asklepios Klinik Sankt Augustin, Centre for General Pediatrics and Neonatology, Sankt Augustin, and University Hospital of Cologne, Cologne; Prof. Hess Children’s Hospital and Pediatric Intensive Care Medicine, Bremen; German Rheumatism Research Centre Berlin, and Charité University Medicine, Department of Rheumatology and Clinical Immunology, Berlin, Germany; Hospital for Special Surgery, Division of Pediatric Rheumatology, New York, New York; Connecticut Children’s Medical Center, Pediatric Rheumatology, Hartford, Connecticut; Tulsa Bone and Joint Associates, Tulsa, Oklahoma; Genentech, South San Francisco, California; University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Division of Rheumatology, Department of Pediatrics, PRCSG Coordinating Center, Cincinnati, Ohio, USA; National Referral Centre of Auto-Inflammatory Diseases, CEREMAIA, Centre Hospitalier Universitaire (CHU) de Bicere, Department of Pediatric Rheumatology, AP-HP, University of Paris Sud, Le Kremlin Bicêtre, France; University Hospital of Ioannina, Unit of Paediatric Rheumatology, Paediatric Clinic, Ioannina, Greece; Children’s Institute, Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo (HCFMUSP), Pediatric Rheumatology Unit, Sao Paulo, Brazil. The study was sponsored by F. Hoffmann-La Roche Ltd., which manufactures tocilizumab. Support for third-party writing assistance was provided by Sara Duggan, PhD, of ApotheCom and was funded by F. Hoffmann-La Roche Ltd. J. Wang is an employee of F. Hoffmann-La Roche Ltd. N. Ruperto is a consultant/speaker for F. Hoffmann-La Roche Ltd. E. Alexeeva is a consultant/speaker for F. Hoffmann-La Roche Ltd. K. Minden is a consultant/speaker or receives honoraria from F. Hoffmann-La Roche Ltd. I. Koné-Paut is a consultant to F. Hoffmann-La Roche Ltd. B. Porter-Brown is an employee of and owns stock in F. Hoffmann-La Roche Ltd. K. Bharucha owns stock in F. Hoffmann-La Roche Ltd. H.I. Brunner is a consultant/speaker or receives honoraria from F. Hoffmann-La Roche Ltd. F. De Benedetti is a consultant/speaker or receives honoraria from F. Hoffmann-La Roche Ltd. M. Pardeo, MD, IRCCS Ospedale Pediatrico Bambino Gesù, Division of Rheumatology; J. Wang, PhD, Roche Products Ltd.; N. Ruperto, MD, MPH, IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO; E. Alexeeva, MD, PhD, Professor, Federal State Autonomous Institution National Medical Research Center of Children’s Health of the Ministry of Health of the Russian Federation, Department of Rheumatology, and Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation, Department of Pediatrics and Pediatric Rheumatology; V. Chasnyk, MD, Professor, Saint-Petersburg State Pediatric Medical University, Department of Hospital Pediatrics; R. Schneider, MBBCh, Hospital for Sick Children, University of Toronto, Department of Pediatrics, Division of Rheumatology; G. Horneff, MD, Professor, Asklepios Klinik Sankt Augustin, Centre for General Pediatrics and Neonatology, Sankt Augustin, and University Hospital of Cologne; H.I. Huppertz, MD, Professor, Prof. Hess Children’s Hospital and Pediatric Intensive Care Medicine; K. Minden, MD, German Rheumatism Research Centre Berlin, and Charité University Medicine, Department of Rheumatology and Clinical Immunology; K. Onel, MD, Professor, Hospital for Special Surgery, Division of Pediatric Rheumatology; L. Zemel, MD, Connecticut Children’s Medical Center, Pediatric Rheumatology; A. Martin, MD, Tulsa Bone and Joint Associates; I. Koné-Paut, MD, National Referral Centre of Auto-Inflammatory Diseases, CEREMAIA, CHU de Bicere, Department of Pediatric Rheumatology, AP-HP, University of Paris Sud; A. Siamopoulou-Mavridou, MD, Professor, University Hospital of Ioannina, Unit of Paediatric Rheumatology, Paediatric Clinic; C.A. Silva, MD, PhD, Associate Professor, Children’s Institute, HCFMUSP, Pediatric Rheumatology Unit; B. Porter-Brown, MBBS, DPM, MFPM, Roche Products Ltd.; K.N. Bharucha, PhD, MD, Genentech (affiliation at time of the study); H.I. Brunner, MD, MSc, University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Division of Rheumatology, Department of Pediatrics, PRCSG Coordinating Center; F. De Benedetti, MD, PhD, IRCCS Ospedale Pediatrico Bambino Gesù, Division of Rheumatology. M. Pardeo and J. Wang contributed equally to the study. Address correspondence to Dr. F. De Benedetti, IRCCS Ospedale Pediatrico Bambino Gesù, Piazza S. Onofrio 4, 00165 Rome, Italy. E-mail: fabrizio.debenedetti@opbg.net. Full Release Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication December 19, 2018.
Gerd Horneff
From the Institute for Research and Health Care (IRCCS) Ospedale Pediatrico Bambino Gesù, Division of Rheumatology, Rome, Italy; Roche Products Ltd., Welwyn Garden City, UK; IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO, Genoa, Italy; Federal State Autonomous Institution National Medical Research Center of Children’s Health of the Ministry of Health of the Russian Federation, Department of Rheumatology, and Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation, Department of Pediatrics and Pediatric Rheumatology, Moscow; Saint-Petersburg State Pediatric Medical University, Department of Hospital Pediatrics, St. Petersburg, Russia; Hospital for Sick Children, University of Toronto, Department of Pediatrics, Division of Rheumatology, Toronto, Ontario, Canada; Asklepios Klinik Sankt Augustin, Centre for General Pediatrics and Neonatology, Sankt Augustin, and University Hospital of Cologne, Cologne; Prof. Hess Children’s Hospital and Pediatric Intensive Care Medicine, Bremen; German Rheumatism Research Centre Berlin, and Charité University Medicine, Department of Rheumatology and Clinical Immunology, Berlin, Germany; Hospital for Special Surgery, Division of Pediatric Rheumatology, New York, New York; Connecticut Children’s Medical Center, Pediatric Rheumatology, Hartford, Connecticut; Tulsa Bone and Joint Associates, Tulsa, Oklahoma; Genentech, South San Francisco, California; University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Division of Rheumatology, Department of Pediatrics, PRCSG Coordinating Center, Cincinnati, Ohio, USA; National Referral Centre of Auto-Inflammatory Diseases, CEREMAIA, Centre Hospitalier Universitaire (CHU) de Bicere, Department of Pediatric Rheumatology, AP-HP, University of Paris Sud, Le Kremlin Bicêtre, France; University Hospital of Ioannina, Unit of Paediatric Rheumatology, Paediatric Clinic, Ioannina, Greece; Children’s Institute, Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo (HCFMUSP), Pediatric Rheumatology Unit, Sao Paulo, Brazil. The study was sponsored by F. Hoffmann-La Roche Ltd., which manufactures tocilizumab. Support for third-party writing assistance was provided by Sara Duggan, PhD, of ApotheCom and was funded by F. Hoffmann-La Roche Ltd. J. Wang is an employee of F. Hoffmann-La Roche Ltd. N. Ruperto is a consultant/speaker for F. Hoffmann-La Roche Ltd. E. Alexeeva is a consultant/speaker for F. Hoffmann-La Roche Ltd. K. Minden is a consultant/speaker or receives honoraria from F. Hoffmann-La Roche Ltd. I. Koné-Paut is a consultant to F. Hoffmann-La Roche Ltd. B. Porter-Brown is an employee of and owns stock in F. Hoffmann-La Roche Ltd. K. Bharucha owns stock in F. Hoffmann-La Roche Ltd. H.I. Brunner is a consultant/speaker or receives honoraria from F. Hoffmann-La Roche Ltd. F. De Benedetti is a consultant/speaker or receives honoraria from F. Hoffmann-La Roche Ltd. M. Pardeo, MD, IRCCS Ospedale Pediatrico Bambino Gesù, Division of Rheumatology; J. Wang, PhD, Roche Products Ltd.; N. Ruperto, MD, MPH, IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO; E. Alexeeva, MD, PhD, Professor, Federal State Autonomous Institution National Medical Research Center of Children’s Health of the Ministry of Health of the Russian Federation, Department of Rheumatology, and Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation, Department of Pediatrics and Pediatric Rheumatology; V. Chasnyk, MD, Professor, Saint-Petersburg State Pediatric Medical University, Department of Hospital Pediatrics; R. Schneider, MBBCh, Hospital for Sick Children, University of Toronto, Department of Pediatrics, Division of Rheumatology; G. Horneff, MD, Professor, Asklepios Klinik Sankt Augustin, Centre for General Pediatrics and Neonatology, Sankt Augustin, and University Hospital of Cologne; H.I. Huppertz, MD, Professor, Prof. Hess Children’s Hospital and Pediatric Intensive Care Medicine; K. Minden, MD, German Rheumatism Research Centre Berlin, and Charité University Medicine, Department of Rheumatology and Clinical Immunology; K. Onel, MD, Professor, Hospital for Special Surgery, Division of Pediatric Rheumatology; L. Zemel, MD, Connecticut Children’s Medical Center, Pediatric Rheumatology; A. Martin, MD, Tulsa Bone and Joint Associates; I. Koné-Paut, MD, National Referral Centre of Auto-Inflammatory Diseases, CEREMAIA, CHU de Bicere, Department of Pediatric Rheumatology, AP-HP, University of Paris Sud; A. Siamopoulou-Mavridou, MD, Professor, University Hospital of Ioannina, Unit of Paediatric Rheumatology, Paediatric Clinic; C.A. Silva, MD, PhD, Associate Professor, Children’s Institute, HCFMUSP, Pediatric Rheumatology Unit; B. Porter-Brown, MBBS, DPM, MFPM, Roche Products Ltd.; K.N. Bharucha, PhD, MD, Genentech (affiliation at time of the study); H.I. Brunner, MD, MSc, University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Division of Rheumatology, Department of Pediatrics, PRCSG Coordinating Center; F. De Benedetti, MD, PhD, IRCCS Ospedale Pediatrico Bambino Gesù, Division of Rheumatology. M. Pardeo and J. Wang contributed equally to the study. Address correspondence to Dr. F. De Benedetti, IRCCS Ospedale Pediatrico Bambino Gesù, Piazza S. Onofrio 4, 00165 Rome, Italy. E-mail: fabrizio.debenedetti@opbg.net. Full Release Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication December 19, 2018.
Hans-Iko Huppertz
From the Institute for Research and Health Care (IRCCS) Ospedale Pediatrico Bambino Gesù, Division of Rheumatology, Rome, Italy; Roche Products Ltd., Welwyn Garden City, UK; IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO, Genoa, Italy; Federal State Autonomous Institution National Medical Research Center of Children’s Health of the Ministry of Health of the Russian Federation, Department of Rheumatology, and Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation, Department of Pediatrics and Pediatric Rheumatology, Moscow; Saint-Petersburg State Pediatric Medical University, Department of Hospital Pediatrics, St. Petersburg, Russia; Hospital for Sick Children, University of Toronto, Department of Pediatrics, Division of Rheumatology, Toronto, Ontario, Canada; Asklepios Klinik Sankt Augustin, Centre for General Pediatrics and Neonatology, Sankt Augustin, and University Hospital of Cologne, Cologne; Prof. Hess Children’s Hospital and Pediatric Intensive Care Medicine, Bremen; German Rheumatism Research Centre Berlin, and Charité University Medicine, Department of Rheumatology and Clinical Immunology, Berlin, Germany; Hospital for Special Surgery, Division of Pediatric Rheumatology, New York, New York; Connecticut Children’s Medical Center, Pediatric Rheumatology, Hartford, Connecticut; Tulsa Bone and Joint Associates, Tulsa, Oklahoma; Genentech, South San Francisco, California; University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Division of Rheumatology, Department of Pediatrics, PRCSG Coordinating Center, Cincinnati, Ohio, USA; National Referral Centre of Auto-Inflammatory Diseases, CEREMAIA, Centre Hospitalier Universitaire (CHU) de Bicere, Department of Pediatric Rheumatology, AP-HP, University of Paris Sud, Le Kremlin Bicêtre, France; University Hospital of Ioannina, Unit of Paediatric Rheumatology, Paediatric Clinic, Ioannina, Greece; Children’s Institute, Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo (HCFMUSP), Pediatric Rheumatology Unit, Sao Paulo, Brazil. The study was sponsored by F. Hoffmann-La Roche Ltd., which manufactures tocilizumab. Support for third-party writing assistance was provided by Sara Duggan, PhD, of ApotheCom and was funded by F. Hoffmann-La Roche Ltd. J. Wang is an employee of F. Hoffmann-La Roche Ltd. N. Ruperto is a consultant/speaker for F. Hoffmann-La Roche Ltd. E. Alexeeva is a consultant/speaker for F. Hoffmann-La Roche Ltd. K. Minden is a consultant/speaker or receives honoraria from F. Hoffmann-La Roche Ltd. I. Koné-Paut is a consultant to F. Hoffmann-La Roche Ltd. B. Porter-Brown is an employee of and owns stock in F. Hoffmann-La Roche Ltd. K. Bharucha owns stock in F. Hoffmann-La Roche Ltd. H.I. Brunner is a consultant/speaker or receives honoraria from F. Hoffmann-La Roche Ltd. F. De Benedetti is a consultant/speaker or receives honoraria from F. Hoffmann-La Roche Ltd. M. Pardeo, MD, IRCCS Ospedale Pediatrico Bambino Gesù, Division of Rheumatology; J. Wang, PhD, Roche Products Ltd.; N. Ruperto, MD, MPH, IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO; E. Alexeeva, MD, PhD, Professor, Federal State Autonomous Institution National Medical Research Center of Children’s Health of the Ministry of Health of the Russian Federation, Department of Rheumatology, and Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation, Department of Pediatrics and Pediatric Rheumatology; V. Chasnyk, MD, Professor, Saint-Petersburg State Pediatric Medical University, Department of Hospital Pediatrics; R. Schneider, MBBCh, Hospital for Sick Children, University of Toronto, Department of Pediatrics, Division of Rheumatology; G. Horneff, MD, Professor, Asklepios Klinik Sankt Augustin, Centre for General Pediatrics and Neonatology, Sankt Augustin, and University Hospital of Cologne; H.I. Huppertz, MD, Professor, Prof. Hess Children’s Hospital and Pediatric Intensive Care Medicine; K. Minden, MD, German Rheumatism Research Centre Berlin, and Charité University Medicine, Department of Rheumatology and Clinical Immunology; K. Onel, MD, Professor, Hospital for Special Surgery, Division of Pediatric Rheumatology; L. Zemel, MD, Connecticut Children’s Medical Center, Pediatric Rheumatology; A. Martin, MD, Tulsa Bone and Joint Associates; I. Koné-Paut, MD, National Referral Centre of Auto-Inflammatory Diseases, CEREMAIA, CHU de Bicere, Department of Pediatric Rheumatology, AP-HP, University of Paris Sud; A. Siamopoulou-Mavridou, MD, Professor, University Hospital of Ioannina, Unit of Paediatric Rheumatology, Paediatric Clinic; C.A. Silva, MD, PhD, Associate Professor, Children’s Institute, HCFMUSP, Pediatric Rheumatology Unit; B. Porter-Brown, MBBS, DPM, MFPM, Roche Products Ltd.; K.N. Bharucha, PhD, MD, Genentech (affiliation at time of the study); H.I. Brunner, MD, MSc, University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Division of Rheumatology, Department of Pediatrics, PRCSG Coordinating Center; F. De Benedetti, MD, PhD, IRCCS Ospedale Pediatrico Bambino Gesù, Division of Rheumatology. M. Pardeo and J. Wang contributed equally to the study. Address correspondence to Dr. F. De Benedetti, IRCCS Ospedale Pediatrico Bambino Gesù, Piazza S. Onofrio 4, 00165 Rome, Italy. E-mail: fabrizio.debenedetti@opbg.net. Full Release Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication December 19, 2018.
Kirsten Minden
From the Institute for Research and Health Care (IRCCS) Ospedale Pediatrico Bambino Gesù, Division of Rheumatology, Rome, Italy; Roche Products Ltd., Welwyn Garden City, UK; IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO, Genoa, Italy; Federal State Autonomous Institution National Medical Research Center of Children’s Health of the Ministry of Health of the Russian Federation, Department of Rheumatology, and Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation, Department of Pediatrics and Pediatric Rheumatology, Moscow; Saint-Petersburg State Pediatric Medical University, Department of Hospital Pediatrics, St. Petersburg, Russia; Hospital for Sick Children, University of Toronto, Department of Pediatrics, Division of Rheumatology, Toronto, Ontario, Canada; Asklepios Klinik Sankt Augustin, Centre for General Pediatrics and Neonatology, Sankt Augustin, and University Hospital of Cologne, Cologne; Prof. Hess Children’s Hospital and Pediatric Intensive Care Medicine, Bremen; German Rheumatism Research Centre Berlin, and Charité University Medicine, Department of Rheumatology and Clinical Immunology, Berlin, Germany; Hospital for Special Surgery, Division of Pediatric Rheumatology, New York, New York; Connecticut Children’s Medical Center, Pediatric Rheumatology, Hartford, Connecticut; Tulsa Bone and Joint Associates, Tulsa, Oklahoma; Genentech, South San Francisco, California; University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Division of Rheumatology, Department of Pediatrics, PRCSG Coordinating Center, Cincinnati, Ohio, USA; National Referral Centre of Auto-Inflammatory Diseases, CEREMAIA, Centre Hospitalier Universitaire (CHU) de Bicere, Department of Pediatric Rheumatology, AP-HP, University of Paris Sud, Le Kremlin Bicêtre, France; University Hospital of Ioannina, Unit of Paediatric Rheumatology, Paediatric Clinic, Ioannina, Greece; Children’s Institute, Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo (HCFMUSP), Pediatric Rheumatology Unit, Sao Paulo, Brazil. The study was sponsored by F. Hoffmann-La Roche Ltd., which manufactures tocilizumab. Support for third-party writing assistance was provided by Sara Duggan, PhD, of ApotheCom and was funded by F. Hoffmann-La Roche Ltd. J. Wang is an employee of F. Hoffmann-La Roche Ltd. N. Ruperto is a consultant/speaker for F. Hoffmann-La Roche Ltd. E. Alexeeva is a consultant/speaker for F. Hoffmann-La Roche Ltd. K. Minden is a consultant/speaker or receives honoraria from F. Hoffmann-La Roche Ltd. I. Koné-Paut is a consultant to F. Hoffmann-La Roche Ltd. B. Porter-Brown is an employee of and owns stock in F. Hoffmann-La Roche Ltd. K. Bharucha owns stock in F. Hoffmann-La Roche Ltd. H.I. Brunner is a consultant/speaker or receives honoraria from F. Hoffmann-La Roche Ltd. F. De Benedetti is a consultant/speaker or receives honoraria from F. Hoffmann-La Roche Ltd. M. Pardeo, MD, IRCCS Ospedale Pediatrico Bambino Gesù, Division of Rheumatology; J. Wang, PhD, Roche Products Ltd.; N. Ruperto, MD, MPH, IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO; E. Alexeeva, MD, PhD, Professor, Federal State Autonomous Institution National Medical Research Center of Children’s Health of the Ministry of Health of the Russian Federation, Department of Rheumatology, and Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation, Department of Pediatrics and Pediatric Rheumatology; V. Chasnyk, MD, Professor, Saint-Petersburg State Pediatric Medical University, Department of Hospital Pediatrics; R. Schneider, MBBCh, Hospital for Sick Children, University of Toronto, Department of Pediatrics, Division of Rheumatology; G. Horneff, MD, Professor, Asklepios Klinik Sankt Augustin, Centre for General Pediatrics and Neonatology, Sankt Augustin, and University Hospital of Cologne; H.I. Huppertz, MD, Professor, Prof. Hess Children’s Hospital and Pediatric Intensive Care Medicine; K. Minden, MD, German Rheumatism Research Centre Berlin, and Charité University Medicine, Department of Rheumatology and Clinical Immunology; K. Onel, MD, Professor, Hospital for Special Surgery, Division of Pediatric Rheumatology; L. Zemel, MD, Connecticut Children’s Medical Center, Pediatric Rheumatology; A. Martin, MD, Tulsa Bone and Joint Associates; I. Koné-Paut, MD, National Referral Centre of Auto-Inflammatory Diseases, CEREMAIA, CHU de Bicere, Department of Pediatric Rheumatology, AP-HP, University of Paris Sud; A. Siamopoulou-Mavridou, MD, Professor, University Hospital of Ioannina, Unit of Paediatric Rheumatology, Paediatric Clinic; C.A. Silva, MD, PhD, Associate Professor, Children’s Institute, HCFMUSP, Pediatric Rheumatology Unit; B. Porter-Brown, MBBS, DPM, MFPM, Roche Products Ltd.; K.N. Bharucha, PhD, MD, Genentech (affiliation at time of the study); H.I. Brunner, MD, MSc, University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Division of Rheumatology, Department of Pediatrics, PRCSG Coordinating Center; F. De Benedetti, MD, PhD, IRCCS Ospedale Pediatrico Bambino Gesù, Division of Rheumatology. M. Pardeo and J. Wang contributed equally to the study. Address correspondence to Dr. F. De Benedetti, IRCCS Ospedale Pediatrico Bambino Gesù, Piazza S. Onofrio 4, 00165 Rome, Italy. E-mail: fabrizio.debenedetti@opbg.net. Full Release Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication December 19, 2018.
Karen Onel
From the Institute for Research and Health Care (IRCCS) Ospedale Pediatrico Bambino Gesù, Division of Rheumatology, Rome, Italy; Roche Products Ltd., Welwyn Garden City, UK; IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO, Genoa, Italy; Federal State Autonomous Institution National Medical Research Center of Children’s Health of the Ministry of Health of the Russian Federation, Department of Rheumatology, and Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation, Department of Pediatrics and Pediatric Rheumatology, Moscow; Saint-Petersburg State Pediatric Medical University, Department of Hospital Pediatrics, St. Petersburg, Russia; Hospital for Sick Children, University of Toronto, Department of Pediatrics, Division of Rheumatology, Toronto, Ontario, Canada; Asklepios Klinik Sankt Augustin, Centre for General Pediatrics and Neonatology, Sankt Augustin, and University Hospital of Cologne, Cologne; Prof. Hess Children’s Hospital and Pediatric Intensive Care Medicine, Bremen; German Rheumatism Research Centre Berlin, and Charité University Medicine, Department of Rheumatology and Clinical Immunology, Berlin, Germany; Hospital for Special Surgery, Division of Pediatric Rheumatology, New York, New York; Connecticut Children’s Medical Center, Pediatric Rheumatology, Hartford, Connecticut; Tulsa Bone and Joint Associates, Tulsa, Oklahoma; Genentech, South San Francisco, California; University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Division of Rheumatology, Department of Pediatrics, PRCSG Coordinating Center, Cincinnati, Ohio, USA; National Referral Centre of Auto-Inflammatory Diseases, CEREMAIA, Centre Hospitalier Universitaire (CHU) de Bicere, Department of Pediatric Rheumatology, AP-HP, University of Paris Sud, Le Kremlin Bicêtre, France; University Hospital of Ioannina, Unit of Paediatric Rheumatology, Paediatric Clinic, Ioannina, Greece; Children’s Institute, Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo (HCFMUSP), Pediatric Rheumatology Unit, Sao Paulo, Brazil. The study was sponsored by F. Hoffmann-La Roche Ltd., which manufactures tocilizumab. Support for third-party writing assistance was provided by Sara Duggan, PhD, of ApotheCom and was funded by F. Hoffmann-La Roche Ltd. J. Wang is an employee of F. Hoffmann-La Roche Ltd. N. Ruperto is a consultant/speaker for F. Hoffmann-La Roche Ltd. E. Alexeeva is a consultant/speaker for F. Hoffmann-La Roche Ltd. K. Minden is a consultant/speaker or receives honoraria from F. Hoffmann-La Roche Ltd. I. Koné-Paut is a consultant to F. Hoffmann-La Roche Ltd. B. Porter-Brown is an employee of and owns stock in F. Hoffmann-La Roche Ltd. K. Bharucha owns stock in F. Hoffmann-La Roche Ltd. H.I. Brunner is a consultant/speaker or receives honoraria from F. Hoffmann-La Roche Ltd. F. De Benedetti is a consultant/speaker or receives honoraria from F. Hoffmann-La Roche Ltd. M. Pardeo, MD, IRCCS Ospedale Pediatrico Bambino Gesù, Division of Rheumatology; J. Wang, PhD, Roche Products Ltd.; N. Ruperto, MD, MPH, IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO; E. Alexeeva, MD, PhD, Professor, Federal State Autonomous Institution National Medical Research Center of Children’s Health of the Ministry of Health of the Russian Federation, Department of Rheumatology, and Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation, Department of Pediatrics and Pediatric Rheumatology; V. Chasnyk, MD, Professor, Saint-Petersburg State Pediatric Medical University, Department of Hospital Pediatrics; R. Schneider, MBBCh, Hospital for Sick Children, University of Toronto, Department of Pediatrics, Division of Rheumatology; G. Horneff, MD, Professor, Asklepios Klinik Sankt Augustin, Centre for General Pediatrics and Neonatology, Sankt Augustin, and University Hospital of Cologne; H.I. Huppertz, MD, Professor, Prof. Hess Children’s Hospital and Pediatric Intensive Care Medicine; K. Minden, MD, German Rheumatism Research Centre Berlin, and Charité University Medicine, Department of Rheumatology and Clinical Immunology; K. Onel, MD, Professor, Hospital for Special Surgery, Division of Pediatric Rheumatology; L. Zemel, MD, Connecticut Children’s Medical Center, Pediatric Rheumatology; A. Martin, MD, Tulsa Bone and Joint Associates; I. Koné-Paut, MD, National Referral Centre of Auto-Inflammatory Diseases, CEREMAIA, CHU de Bicere, Department of Pediatric Rheumatology, AP-HP, University of Paris Sud; A. Siamopoulou-Mavridou, MD, Professor, University Hospital of Ioannina, Unit of Paediatric Rheumatology, Paediatric Clinic; C.A. Silva, MD, PhD, Associate Professor, Children’s Institute, HCFMUSP, Pediatric Rheumatology Unit; B. Porter-Brown, MBBS, DPM, MFPM, Roche Products Ltd.; K.N. Bharucha, PhD, MD, Genentech (affiliation at time of the study); H.I. Brunner, MD, MSc, University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Division of Rheumatology, Department of Pediatrics, PRCSG Coordinating Center; F. De Benedetti, MD, PhD, IRCCS Ospedale Pediatrico Bambino Gesù, Division of Rheumatology. M. Pardeo and J. Wang contributed equally to the study. Address correspondence to Dr. F. De Benedetti, IRCCS Ospedale Pediatrico Bambino Gesù, Piazza S. Onofrio 4, 00165 Rome, Italy. E-mail: fabrizio.debenedetti@opbg.net. Full Release Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication December 19, 2018.
Lawrence Zemel
From the Institute for Research and Health Care (IRCCS) Ospedale Pediatrico Bambino Gesù, Division of Rheumatology, Rome, Italy; Roche Products Ltd., Welwyn Garden City, UK; IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO, Genoa, Italy; Federal State Autonomous Institution National Medical Research Center of Children’s Health of the Ministry of Health of the Russian Federation, Department of Rheumatology, and Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation, Department of Pediatrics and Pediatric Rheumatology, Moscow; Saint-Petersburg State Pediatric Medical University, Department of Hospital Pediatrics, St. Petersburg, Russia; Hospital for Sick Children, University of Toronto, Department of Pediatrics, Division of Rheumatology, Toronto, Ontario, Canada; Asklepios Klinik Sankt Augustin, Centre for General Pediatrics and Neonatology, Sankt Augustin, and University Hospital of Cologne, Cologne; Prof. Hess Children’s Hospital and Pediatric Intensive Care Medicine, Bremen; German Rheumatism Research Centre Berlin, and Charité University Medicine, Department of Rheumatology and Clinical Immunology, Berlin, Germany; Hospital for Special Surgery, Division of Pediatric Rheumatology, New York, New York; Connecticut Children’s Medical Center, Pediatric Rheumatology, Hartford, Connecticut; Tulsa Bone and Joint Associates, Tulsa, Oklahoma; Genentech, South San Francisco, California; University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Division of Rheumatology, Department of Pediatrics, PRCSG Coordinating Center, Cincinnati, Ohio, USA; National Referral Centre of Auto-Inflammatory Diseases, CEREMAIA, Centre Hospitalier Universitaire (CHU) de Bicere, Department of Pediatric Rheumatology, AP-HP, University of Paris Sud, Le Kremlin Bicêtre, France; University Hospital of Ioannina, Unit of Paediatric Rheumatology, Paediatric Clinic, Ioannina, Greece; Children’s Institute, Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo (HCFMUSP), Pediatric Rheumatology Unit, Sao Paulo, Brazil. The study was sponsored by F. Hoffmann-La Roche Ltd., which manufactures tocilizumab. Support for third-party writing assistance was provided by Sara Duggan, PhD, of ApotheCom and was funded by F. Hoffmann-La Roche Ltd. J. Wang is an employee of F. Hoffmann-La Roche Ltd. N. Ruperto is a consultant/speaker for F. Hoffmann-La Roche Ltd. E. Alexeeva is a consultant/speaker for F. Hoffmann-La Roche Ltd. K. Minden is a consultant/speaker or receives honoraria from F. Hoffmann-La Roche Ltd. I. Koné-Paut is a consultant to F. Hoffmann-La Roche Ltd. B. Porter-Brown is an employee of and owns stock in F. Hoffmann-La Roche Ltd. K. Bharucha owns stock in F. Hoffmann-La Roche Ltd. H.I. Brunner is a consultant/speaker or receives honoraria from F. Hoffmann-La Roche Ltd. F. De Benedetti is a consultant/speaker or receives honoraria from F. Hoffmann-La Roche Ltd. M. Pardeo, MD, IRCCS Ospedale Pediatrico Bambino Gesù, Division of Rheumatology; J. Wang, PhD, Roche Products Ltd.; N. Ruperto, MD, MPH, IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO; E. Alexeeva, MD, PhD, Professor, Federal State Autonomous Institution National Medical Research Center of Children’s Health of the Ministry of Health of the Russian Federation, Department of Rheumatology, and Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation, Department of Pediatrics and Pediatric Rheumatology; V. Chasnyk, MD, Professor, Saint-Petersburg State Pediatric Medical University, Department of Hospital Pediatrics; R. Schneider, MBBCh, Hospital for Sick Children, University of Toronto, Department of Pediatrics, Division of Rheumatology; G. Horneff, MD, Professor, Asklepios Klinik Sankt Augustin, Centre for General Pediatrics and Neonatology, Sankt Augustin, and University Hospital of Cologne; H.I. Huppertz, MD, Professor, Prof. Hess Children’s Hospital and Pediatric Intensive Care Medicine; K. Minden, MD, German Rheumatism Research Centre Berlin, and Charité University Medicine, Department of Rheumatology and Clinical Immunology; K. Onel, MD, Professor, Hospital for Special Surgery, Division of Pediatric Rheumatology; L. Zemel, MD, Connecticut Children’s Medical Center, Pediatric Rheumatology; A. Martin, MD, Tulsa Bone and Joint Associates; I. Koné-Paut, MD, National Referral Centre of Auto-Inflammatory Diseases, CEREMAIA, CHU de Bicere, Department of Pediatric Rheumatology, AP-HP, University of Paris Sud; A. Siamopoulou-Mavridou, MD, Professor, University Hospital of Ioannina, Unit of Paediatric Rheumatology, Paediatric Clinic; C.A. Silva, MD, PhD, Associate Professor, Children’s Institute, HCFMUSP, Pediatric Rheumatology Unit; B. Porter-Brown, MBBS, DPM, MFPM, Roche Products Ltd.; K.N. Bharucha, PhD, MD, Genentech (affiliation at time of the study); H.I. Brunner, MD, MSc, University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Division of Rheumatology, Department of Pediatrics, PRCSG Coordinating Center; F. De Benedetti, MD, PhD, IRCCS Ospedale Pediatrico Bambino Gesù, Division of Rheumatology. M. Pardeo and J. Wang contributed equally to the study. Address correspondence to Dr. F. De Benedetti, IRCCS Ospedale Pediatrico Bambino Gesù, Piazza S. Onofrio 4, 00165 Rome, Italy. E-mail: fabrizio.debenedetti@opbg.net. Full Release Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication December 19, 2018.
Alan Martin
From the Institute for Research and Health Care (IRCCS) Ospedale Pediatrico Bambino Gesù, Division of Rheumatology, Rome, Italy; Roche Products Ltd., Welwyn Garden City, UK; IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO, Genoa, Italy; Federal State Autonomous Institution National Medical Research Center of Children’s Health of the Ministry of Health of the Russian Federation, Department of Rheumatology, and Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation, Department of Pediatrics and Pediatric Rheumatology, Moscow; Saint-Petersburg State Pediatric Medical University, Department of Hospital Pediatrics, St. Petersburg, Russia; Hospital for Sick Children, University of Toronto, Department of Pediatrics, Division of Rheumatology, Toronto, Ontario, Canada; Asklepios Klinik Sankt Augustin, Centre for General Pediatrics and Neonatology, Sankt Augustin, and University Hospital of Cologne, Cologne; Prof. Hess Children’s Hospital and Pediatric Intensive Care Medicine, Bremen; German Rheumatism Research Centre Berlin, and Charité University Medicine, Department of Rheumatology and Clinical Immunology, Berlin, Germany; Hospital for Special Surgery, Division of Pediatric Rheumatology, New York, New York; Connecticut Children’s Medical Center, Pediatric Rheumatology, Hartford, Connecticut; Tulsa Bone and Joint Associates, Tulsa, Oklahoma; Genentech, South San Francisco, California; University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Division of Rheumatology, Department of Pediatrics, PRCSG Coordinating Center, Cincinnati, Ohio, USA; National Referral Centre of Auto-Inflammatory Diseases, CEREMAIA, Centre Hospitalier Universitaire (CHU) de Bicere, Department of Pediatric Rheumatology, AP-HP, University of Paris Sud, Le Kremlin Bicêtre, France; University Hospital of Ioannina, Unit of Paediatric Rheumatology, Paediatric Clinic, Ioannina, Greece; Children’s Institute, Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo (HCFMUSP), Pediatric Rheumatology Unit, Sao Paulo, Brazil. The study was sponsored by F. Hoffmann-La Roche Ltd., which manufactures tocilizumab. Support for third-party writing assistance was provided by Sara Duggan, PhD, of ApotheCom and was funded by F. Hoffmann-La Roche Ltd. J. Wang is an employee of F. Hoffmann-La Roche Ltd. N. Ruperto is a consultant/speaker for F. Hoffmann-La Roche Ltd. E. Alexeeva is a consultant/speaker for F. Hoffmann-La Roche Ltd. K. Minden is a consultant/speaker or receives honoraria from F. Hoffmann-La Roche Ltd. I. Koné-Paut is a consultant to F. Hoffmann-La Roche Ltd. B. Porter-Brown is an employee of and owns stock in F. Hoffmann-La Roche Ltd. K. Bharucha owns stock in F. Hoffmann-La Roche Ltd. H.I. Brunner is a consultant/speaker or receives honoraria from F. Hoffmann-La Roche Ltd. F. De Benedetti is a consultant/speaker or receives honoraria from F. Hoffmann-La Roche Ltd. M. Pardeo, MD, IRCCS Ospedale Pediatrico Bambino Gesù, Division of Rheumatology; J. Wang, PhD, Roche Products Ltd.; N. Ruperto, MD, MPH, IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO; E. Alexeeva, MD, PhD, Professor, Federal State Autonomous Institution National Medical Research Center of Children’s Health of the Ministry of Health of the Russian Federation, Department of Rheumatology, and Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation, Department of Pediatrics and Pediatric Rheumatology; V. Chasnyk, MD, Professor, Saint-Petersburg State Pediatric Medical University, Department of Hospital Pediatrics; R. Schneider, MBBCh, Hospital for Sick Children, University of Toronto, Department of Pediatrics, Division of Rheumatology; G. Horneff, MD, Professor, Asklepios Klinik Sankt Augustin, Centre for General Pediatrics and Neonatology, Sankt Augustin, and University Hospital of Cologne; H.I. Huppertz, MD, Professor, Prof. Hess Children’s Hospital and Pediatric Intensive Care Medicine; K. Minden, MD, German Rheumatism Research Centre Berlin, and Charité University Medicine, Department of Rheumatology and Clinical Immunology; K. Onel, MD, Professor, Hospital for Special Surgery, Division of Pediatric Rheumatology; L. Zemel, MD, Connecticut Children’s Medical Center, Pediatric Rheumatology; A. Martin, MD, Tulsa Bone and Joint Associates; I. Koné-Paut, MD, National Referral Centre of Auto-Inflammatory Diseases, CEREMAIA, CHU de Bicere, Department of Pediatric Rheumatology, AP-HP, University of Paris Sud; A. Siamopoulou-Mavridou, MD, Professor, University Hospital of Ioannina, Unit of Paediatric Rheumatology, Paediatric Clinic; C.A. Silva, MD, PhD, Associate Professor, Children’s Institute, HCFMUSP, Pediatric Rheumatology Unit; B. Porter-Brown, MBBS, DPM, MFPM, Roche Products Ltd.; K.N. Bharucha, PhD, MD, Genentech (affiliation at time of the study); H.I. Brunner, MD, MSc, University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Division of Rheumatology, Department of Pediatrics, PRCSG Coordinating Center; F. De Benedetti, MD, PhD, IRCCS Ospedale Pediatrico Bambino Gesù, Division of Rheumatology. M. Pardeo and J. Wang contributed equally to the study. Address correspondence to Dr. F. De Benedetti, IRCCS Ospedale Pediatrico Bambino Gesù, Piazza S. Onofrio 4, 00165 Rome, Italy. E-mail: fabrizio.debenedetti@opbg.net. Full Release Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication December 19, 2018.
Isabelle Koné-Paut
From the Institute for Research and Health Care (IRCCS) Ospedale Pediatrico Bambino Gesù, Division of Rheumatology, Rome, Italy; Roche Products Ltd., Welwyn Garden City, UK; IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO, Genoa, Italy; Federal State Autonomous Institution National Medical Research Center of Children’s Health of the Ministry of Health of the Russian Federation, Department of Rheumatology, and Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation, Department of Pediatrics and Pediatric Rheumatology, Moscow; Saint-Petersburg State Pediatric Medical University, Department of Hospital Pediatrics, St. Petersburg, Russia; Hospital for Sick Children, University of Toronto, Department of Pediatrics, Division of Rheumatology, Toronto, Ontario, Canada; Asklepios Klinik Sankt Augustin, Centre for General Pediatrics and Neonatology, Sankt Augustin, and University Hospital of Cologne, Cologne; Prof. Hess Children’s Hospital and Pediatric Intensive Care Medicine, Bremen; German Rheumatism Research Centre Berlin, and Charité University Medicine, Department of Rheumatology and Clinical Immunology, Berlin, Germany; Hospital for Special Surgery, Division of Pediatric Rheumatology, New York, New York; Connecticut Children’s Medical Center, Pediatric Rheumatology, Hartford, Connecticut; Tulsa Bone and Joint Associates, Tulsa, Oklahoma; Genentech, South San Francisco, California; University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Division of Rheumatology, Department of Pediatrics, PRCSG Coordinating Center, Cincinnati, Ohio, USA; National Referral Centre of Auto-Inflammatory Diseases, CEREMAIA, Centre Hospitalier Universitaire (CHU) de Bicere, Department of Pediatric Rheumatology, AP-HP, University of Paris Sud, Le Kremlin Bicêtre, France; University Hospital of Ioannina, Unit of Paediatric Rheumatology, Paediatric Clinic, Ioannina, Greece; Children’s Institute, Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo (HCFMUSP), Pediatric Rheumatology Unit, Sao Paulo, Brazil. The study was sponsored by F. Hoffmann-La Roche Ltd., which manufactures tocilizumab. Support for third-party writing assistance was provided by Sara Duggan, PhD, of ApotheCom and was funded by F. Hoffmann-La Roche Ltd. J. Wang is an employee of F. Hoffmann-La Roche Ltd. N. Ruperto is a consultant/speaker for F. Hoffmann-La Roche Ltd. E. Alexeeva is a consultant/speaker for F. Hoffmann-La Roche Ltd. K. Minden is a consultant/speaker or receives honoraria from F. Hoffmann-La Roche Ltd. I. Koné-Paut is a consultant to F. Hoffmann-La Roche Ltd. B. Porter-Brown is an employee of and owns stock in F. Hoffmann-La Roche Ltd. K. Bharucha owns stock in F. Hoffmann-La Roche Ltd. H.I. Brunner is a consultant/speaker or receives honoraria from F. Hoffmann-La Roche Ltd. F. De Benedetti is a consultant/speaker or receives honoraria from F. Hoffmann-La Roche Ltd. M. Pardeo, MD, IRCCS Ospedale Pediatrico Bambino Gesù, Division of Rheumatology; J. Wang, PhD, Roche Products Ltd.; N. Ruperto, MD, MPH, IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO; E. Alexeeva, MD, PhD, Professor, Federal State Autonomous Institution National Medical Research Center of Children’s Health of the Ministry of Health of the Russian Federation, Department of Rheumatology, and Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation, Department of Pediatrics and Pediatric Rheumatology; V. Chasnyk, MD, Professor, Saint-Petersburg State Pediatric Medical University, Department of Hospital Pediatrics; R. Schneider, MBBCh, Hospital for Sick Children, University of Toronto, Department of Pediatrics, Division of Rheumatology; G. Horneff, MD, Professor, Asklepios Klinik Sankt Augustin, Centre for General Pediatrics and Neonatology, Sankt Augustin, and University Hospital of Cologne; H.I. Huppertz, MD, Professor, Prof. Hess Children’s Hospital and Pediatric Intensive Care Medicine; K. Minden, MD, German Rheumatism Research Centre Berlin, and Charité University Medicine, Department of Rheumatology and Clinical Immunology; K. Onel, MD, Professor, Hospital for Special Surgery, Division of Pediatric Rheumatology; L. Zemel, MD, Connecticut Children’s Medical Center, Pediatric Rheumatology; A. Martin, MD, Tulsa Bone and Joint Associates; I. Koné-Paut, MD, National Referral Centre of Auto-Inflammatory Diseases, CEREMAIA, CHU de Bicere, Department of Pediatric Rheumatology, AP-HP, University of Paris Sud; A. Siamopoulou-Mavridou, MD, Professor, University Hospital of Ioannina, Unit of Paediatric Rheumatology, Paediatric Clinic; C.A. Silva, MD, PhD, Associate Professor, Children’s Institute, HCFMUSP, Pediatric Rheumatology Unit; B. Porter-Brown, MBBS, DPM, MFPM, Roche Products Ltd.; K.N. Bharucha, PhD, MD, Genentech (affiliation at time of the study); H.I. Brunner, MD, MSc, University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Division of Rheumatology, Department of Pediatrics, PRCSG Coordinating Center; F. De Benedetti, MD, PhD, IRCCS Ospedale Pediatrico Bambino Gesù, Division of Rheumatology. M. Pardeo and J. Wang contributed equally to the study. Address correspondence to Dr. F. De Benedetti, IRCCS Ospedale Pediatrico Bambino Gesù, Piazza S. Onofrio 4, 00165 Rome, Italy. E-mail: fabrizio.debenedetti@opbg.net. Full Release Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication December 19, 2018.
Antigoni Siamopoulou-Mavridou
From the Institute for Research and Health Care (IRCCS) Ospedale Pediatrico Bambino Gesù, Division of Rheumatology, Rome, Italy; Roche Products Ltd., Welwyn Garden City, UK; IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO, Genoa, Italy; Federal State Autonomous Institution National Medical Research Center of Children’s Health of the Ministry of Health of the Russian Federation, Department of Rheumatology, and Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation, Department of Pediatrics and Pediatric Rheumatology, Moscow; Saint-Petersburg State Pediatric Medical University, Department of Hospital Pediatrics, St. Petersburg, Russia; Hospital for Sick Children, University of Toronto, Department of Pediatrics, Division of Rheumatology, Toronto, Ontario, Canada; Asklepios Klinik Sankt Augustin, Centre for General Pediatrics and Neonatology, Sankt Augustin, and University Hospital of Cologne, Cologne; Prof. Hess Children’s Hospital and Pediatric Intensive Care Medicine, Bremen; German Rheumatism Research Centre Berlin, and Charité University Medicine, Department of Rheumatology and Clinical Immunology, Berlin, Germany; Hospital for Special Surgery, Division of Pediatric Rheumatology, New York, New York; Connecticut Children’s Medical Center, Pediatric Rheumatology, Hartford, Connecticut; Tulsa Bone and Joint Associates, Tulsa, Oklahoma; Genentech, South San Francisco, California; University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Division of Rheumatology, Department of Pediatrics, PRCSG Coordinating Center, Cincinnati, Ohio, USA; National Referral Centre of Auto-Inflammatory Diseases, CEREMAIA, Centre Hospitalier Universitaire (CHU) de Bicere, Department of Pediatric Rheumatology, AP-HP, University of Paris Sud, Le Kremlin Bicêtre, France; University Hospital of Ioannina, Unit of Paediatric Rheumatology, Paediatric Clinic, Ioannina, Greece; Children’s Institute, Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo (HCFMUSP), Pediatric Rheumatology Unit, Sao Paulo, Brazil. The study was sponsored by F. Hoffmann-La Roche Ltd., which manufactures tocilizumab. Support for third-party writing assistance was provided by Sara Duggan, PhD, of ApotheCom and was funded by F. Hoffmann-La Roche Ltd. J. Wang is an employee of F. Hoffmann-La Roche Ltd. N. Ruperto is a consultant/speaker for F. Hoffmann-La Roche Ltd. E. Alexeeva is a consultant/speaker for F. Hoffmann-La Roche Ltd. K. Minden is a consultant/speaker or receives honoraria from F. Hoffmann-La Roche Ltd. I. Koné-Paut is a consultant to F. Hoffmann-La Roche Ltd. B. Porter-Brown is an employee of and owns stock in F. Hoffmann-La Roche Ltd. K. Bharucha owns stock in F. Hoffmann-La Roche Ltd. H.I. Brunner is a consultant/speaker or receives honoraria from F. Hoffmann-La Roche Ltd. F. De Benedetti is a consultant/speaker or receives honoraria from F. Hoffmann-La Roche Ltd. M. Pardeo, MD, IRCCS Ospedale Pediatrico Bambino Gesù, Division of Rheumatology; J. Wang, PhD, Roche Products Ltd.; N. Ruperto, MD, MPH, IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO; E. Alexeeva, MD, PhD, Professor, Federal State Autonomous Institution National Medical Research Center of Children’s Health of the Ministry of Health of the Russian Federation, Department of Rheumatology, and Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation, Department of Pediatrics and Pediatric Rheumatology; V. Chasnyk, MD, Professor, Saint-Petersburg State Pediatric Medical University, Department of Hospital Pediatrics; R. Schneider, MBBCh, Hospital for Sick Children, University of Toronto, Department of Pediatrics, Division of Rheumatology; G. Horneff, MD, Professor, Asklepios Klinik Sankt Augustin, Centre for General Pediatrics and Neonatology, Sankt Augustin, and University Hospital of Cologne; H.I. Huppertz, MD, Professor, Prof. Hess Children’s Hospital and Pediatric Intensive Care Medicine; K. Minden, MD, German Rheumatism Research Centre Berlin, and Charité University Medicine, Department of Rheumatology and Clinical Immunology; K. Onel, MD, Professor, Hospital for Special Surgery, Division of Pediatric Rheumatology; L. Zemel, MD, Connecticut Children’s Medical Center, Pediatric Rheumatology; A. Martin, MD, Tulsa Bone and Joint Associates; I. Koné-Paut, MD, National Referral Centre of Auto-Inflammatory Diseases, CEREMAIA, CHU de Bicere, Department of Pediatric Rheumatology, AP-HP, University of Paris Sud; A. Siamopoulou-Mavridou, MD, Professor, University Hospital of Ioannina, Unit of Paediatric Rheumatology, Paediatric Clinic; C.A. Silva, MD, PhD, Associate Professor, Children’s Institute, HCFMUSP, Pediatric Rheumatology Unit; B. Porter-Brown, MBBS, DPM, MFPM, Roche Products Ltd.; K.N. Bharucha, PhD, MD, Genentech (affiliation at time of the study); H.I. Brunner, MD, MSc, University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Division of Rheumatology, Department of Pediatrics, PRCSG Coordinating Center; F. De Benedetti, MD, PhD, IRCCS Ospedale Pediatrico Bambino Gesù, Division of Rheumatology. M. Pardeo and J. Wang contributed equally to the study. Address correspondence to Dr. F. De Benedetti, IRCCS Ospedale Pediatrico Bambino Gesù, Piazza S. Onofrio 4, 00165 Rome, Italy. E-mail: fabrizio.debenedetti@opbg.net. Full Release Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication December 19, 2018.
Clovis A. Silva
From the Institute for Research and Health Care (IRCCS) Ospedale Pediatrico Bambino Gesù, Division of Rheumatology, Rome, Italy; Roche Products Ltd., Welwyn Garden City, UK; IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO, Genoa, Italy; Federal State Autonomous Institution National Medical Research Center of Children’s Health of the Ministry of Health of the Russian Federation, Department of Rheumatology, and Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation, Department of Pediatrics and Pediatric Rheumatology, Moscow; Saint-Petersburg State Pediatric Medical University, Department of Hospital Pediatrics, St. Petersburg, Russia; Hospital for Sick Children, University of Toronto, Department of Pediatrics, Division of Rheumatology, Toronto, Ontario, Canada; Asklepios Klinik Sankt Augustin, Centre for General Pediatrics and Neonatology, Sankt Augustin, and University Hospital of Cologne, Cologne; Prof. Hess Children’s Hospital and Pediatric Intensive Care Medicine, Bremen; German Rheumatism Research Centre Berlin, and Charité University Medicine, Department of Rheumatology and Clinical Immunology, Berlin, Germany; Hospital for Special Surgery, Division of Pediatric Rheumatology, New York, New York; Connecticut Children’s Medical Center, Pediatric Rheumatology, Hartford, Connecticut; Tulsa Bone and Joint Associates, Tulsa, Oklahoma; Genentech, South San Francisco, California; University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Division of Rheumatology, Department of Pediatrics, PRCSG Coordinating Center, Cincinnati, Ohio, USA; National Referral Centre of Auto-Inflammatory Diseases, CEREMAIA, Centre Hospitalier Universitaire (CHU) de Bicere, Department of Pediatric Rheumatology, AP-HP, University of Paris Sud, Le Kremlin Bicêtre, France; University Hospital of Ioannina, Unit of Paediatric Rheumatology, Paediatric Clinic, Ioannina, Greece; Children’s Institute, Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo (HCFMUSP), Pediatric Rheumatology Unit, Sao Paulo, Brazil. The study was sponsored by F. Hoffmann-La Roche Ltd., which manufactures tocilizumab. Support for third-party writing assistance was provided by Sara Duggan, PhD, of ApotheCom and was funded by F. Hoffmann-La Roche Ltd. J. Wang is an employee of F. Hoffmann-La Roche Ltd. N. Ruperto is a consultant/speaker for F. Hoffmann-La Roche Ltd. E. Alexeeva is a consultant/speaker for F. Hoffmann-La Roche Ltd. K. Minden is a consultant/speaker or receives honoraria from F. Hoffmann-La Roche Ltd. I. Koné-Paut is a consultant to F. Hoffmann-La Roche Ltd. B. Porter-Brown is an employee of and owns stock in F. Hoffmann-La Roche Ltd. K. Bharucha owns stock in F. Hoffmann-La Roche Ltd. H.I. Brunner is a consultant/speaker or receives honoraria from F. Hoffmann-La Roche Ltd. F. De Benedetti is a consultant/speaker or receives honoraria from F. Hoffmann-La Roche Ltd. M. Pardeo, MD, IRCCS Ospedale Pediatrico Bambino Gesù, Division of Rheumatology; J. Wang, PhD, Roche Products Ltd.; N. Ruperto, MD, MPH, IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO; E. Alexeeva, MD, PhD, Professor, Federal State Autonomous Institution National Medical Research Center of Children’s Health of the Ministry of Health of the Russian Federation, Department of Rheumatology, and Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation, Department of Pediatrics and Pediatric Rheumatology; V. Chasnyk, MD, Professor, Saint-Petersburg State Pediatric Medical University, Department of Hospital Pediatrics; R. Schneider, MBBCh, Hospital for Sick Children, University of Toronto, Department of Pediatrics, Division of Rheumatology; G. Horneff, MD, Professor, Asklepios Klinik Sankt Augustin, Centre for General Pediatrics and Neonatology, Sankt Augustin, and University Hospital of Cologne; H.I. Huppertz, MD, Professor, Prof. Hess Children’s Hospital and Pediatric Intensive Care Medicine; K. Minden, MD, German Rheumatism Research Centre Berlin, and Charité University Medicine, Department of Rheumatology and Clinical Immunology; K. Onel, MD, Professor, Hospital for Special Surgery, Division of Pediatric Rheumatology; L. Zemel, MD, Connecticut Children’s Medical Center, Pediatric Rheumatology; A. Martin, MD, Tulsa Bone and Joint Associates; I. Koné-Paut, MD, National Referral Centre of Auto-Inflammatory Diseases, CEREMAIA, CHU de Bicere, Department of Pediatric Rheumatology, AP-HP, University of Paris Sud; A. Siamopoulou-Mavridou, MD, Professor, University Hospital of Ioannina, Unit of Paediatric Rheumatology, Paediatric Clinic; C.A. Silva, MD, PhD, Associate Professor, Children’s Institute, HCFMUSP, Pediatric Rheumatology Unit; B. Porter-Brown, MBBS, DPM, MFPM, Roche Products Ltd.; K.N. Bharucha, PhD, MD, Genentech (affiliation at time of the study); H.I. Brunner, MD, MSc, University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Division of Rheumatology, Department of Pediatrics, PRCSG Coordinating Center; F. De Benedetti, MD, PhD, IRCCS Ospedale Pediatrico Bambino Gesù, Division of Rheumatology. M. Pardeo and J. Wang contributed equally to the study. Address correspondence to Dr. F. De Benedetti, IRCCS Ospedale Pediatrico Bambino Gesù, Piazza S. Onofrio 4, 00165 Rome, Italy. E-mail: fabrizio.debenedetti@opbg.net. Full Release Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication December 19, 2018.
Benjamin Porter-Brown
From the Institute for Research and Health Care (IRCCS) Ospedale Pediatrico Bambino Gesù, Division of Rheumatology, Rome, Italy; Roche Products Ltd., Welwyn Garden City, UK; IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO, Genoa, Italy; Federal State Autonomous Institution National Medical Research Center of Children’s Health of the Ministry of Health of the Russian Federation, Department of Rheumatology, and Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation, Department of Pediatrics and Pediatric Rheumatology, Moscow; Saint-Petersburg State Pediatric Medical University, Department of Hospital Pediatrics, St. Petersburg, Russia; Hospital for Sick Children, University of Toronto, Department of Pediatrics, Division of Rheumatology, Toronto, Ontario, Canada; Asklepios Klinik Sankt Augustin, Centre for General Pediatrics and Neonatology, Sankt Augustin, and University Hospital of Cologne, Cologne; Prof. Hess Children’s Hospital and Pediatric Intensive Care Medicine, Bremen; German Rheumatism Research Centre Berlin, and Charité University Medicine, Department of Rheumatology and Clinical Immunology, Berlin, Germany; Hospital for Special Surgery, Division of Pediatric Rheumatology, New York, New York; Connecticut Children’s Medical Center, Pediatric Rheumatology, Hartford, Connecticut; Tulsa Bone and Joint Associates, Tulsa, Oklahoma; Genentech, South San Francisco, California; University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Division of Rheumatology, Department of Pediatrics, PRCSG Coordinating Center, Cincinnati, Ohio, USA; National Referral Centre of Auto-Inflammatory Diseases, CEREMAIA, Centre Hospitalier Universitaire (CHU) de Bicere, Department of Pediatric Rheumatology, AP-HP, University of Paris Sud, Le Kremlin Bicêtre, France; University Hospital of Ioannina, Unit of Paediatric Rheumatology, Paediatric Clinic, Ioannina, Greece; Children’s Institute, Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo (HCFMUSP), Pediatric Rheumatology Unit, Sao Paulo, Brazil. The study was sponsored by F. Hoffmann-La Roche Ltd., which manufactures tocilizumab. Support for third-party writing assistance was provided by Sara Duggan, PhD, of ApotheCom and was funded by F. Hoffmann-La Roche Ltd. J. Wang is an employee of F. Hoffmann-La Roche Ltd. N. Ruperto is a consultant/speaker for F. Hoffmann-La Roche Ltd. E. Alexeeva is a consultant/speaker for F. Hoffmann-La Roche Ltd. K. Minden is a consultant/speaker or receives honoraria from F. Hoffmann-La Roche Ltd. I. Koné-Paut is a consultant to F. Hoffmann-La Roche Ltd. B. Porter-Brown is an employee of and owns stock in F. Hoffmann-La Roche Ltd. K. Bharucha owns stock in F. Hoffmann-La Roche Ltd. H.I. Brunner is a consultant/speaker or receives honoraria from F. Hoffmann-La Roche Ltd. F. De Benedetti is a consultant/speaker or receives honoraria from F. Hoffmann-La Roche Ltd. M. Pardeo, MD, IRCCS Ospedale Pediatrico Bambino Gesù, Division of Rheumatology; J. Wang, PhD, Roche Products Ltd.; N. Ruperto, MD, MPH, IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO; E. Alexeeva, MD, PhD, Professor, Federal State Autonomous Institution National Medical Research Center of Children’s Health of the Ministry of Health of the Russian Federation, Department of Rheumatology, and Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation, Department of Pediatrics and Pediatric Rheumatology; V. Chasnyk, MD, Professor, Saint-Petersburg State Pediatric Medical University, Department of Hospital Pediatrics; R. Schneider, MBBCh, Hospital for Sick Children, University of Toronto, Department of Pediatrics, Division of Rheumatology; G. Horneff, MD, Professor, Asklepios Klinik Sankt Augustin, Centre for General Pediatrics and Neonatology, Sankt Augustin, and University Hospital of Cologne; H.I. Huppertz, MD, Professor, Prof. Hess Children’s Hospital and Pediatric Intensive Care Medicine; K. Minden, MD, German Rheumatism Research Centre Berlin, and Charité University Medicine, Department of Rheumatology and Clinical Immunology; K. Onel, MD, Professor, Hospital for Special Surgery, Division of Pediatric Rheumatology; L. Zemel, MD, Connecticut Children’s Medical Center, Pediatric Rheumatology; A. Martin, MD, Tulsa Bone and Joint Associates; I. Koné-Paut, MD, National Referral Centre of Auto-Inflammatory Diseases, CEREMAIA, CHU de Bicere, Department of Pediatric Rheumatology, AP-HP, University of Paris Sud; A. Siamopoulou-Mavridou, MD, Professor, University Hospital of Ioannina, Unit of Paediatric Rheumatology, Paediatric Clinic; C.A. Silva, MD, PhD, Associate Professor, Children’s Institute, HCFMUSP, Pediatric Rheumatology Unit; B. Porter-Brown, MBBS, DPM, MFPM, Roche Products Ltd.; K.N. Bharucha, PhD, MD, Genentech (affiliation at time of the study); H.I. Brunner, MD, MSc, University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Division of Rheumatology, Department of Pediatrics, PRCSG Coordinating Center; F. De Benedetti, MD, PhD, IRCCS Ospedale Pediatrico Bambino Gesù, Division of Rheumatology. M. Pardeo and J. Wang contributed equally to the study. Address correspondence to Dr. F. De Benedetti, IRCCS Ospedale Pediatrico Bambino Gesù, Piazza S. Onofrio 4, 00165 Rome, Italy. E-mail: fabrizio.debenedetti@opbg.net. Full Release Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication December 19, 2018.
Kamal N. Bharucha
From the Institute for Research and Health Care (IRCCS) Ospedale Pediatrico Bambino Gesù, Division of Rheumatology, Rome, Italy; Roche Products Ltd., Welwyn Garden City, UK; IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO, Genoa, Italy; Federal State Autonomous Institution National Medical Research Center of Children’s Health of the Ministry of Health of the Russian Federation, Department of Rheumatology, and Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation, Department of Pediatrics and Pediatric Rheumatology, Moscow; Saint-Petersburg State Pediatric Medical University, Department of Hospital Pediatrics, St. Petersburg, Russia; Hospital for Sick Children, University of Toronto, Department of Pediatrics, Division of Rheumatology, Toronto, Ontario, Canada; Asklepios Klinik Sankt Augustin, Centre for General Pediatrics and Neonatology, Sankt Augustin, and University Hospital of Cologne, Cologne; Prof. Hess Children’s Hospital and Pediatric Intensive Care Medicine, Bremen; German Rheumatism Research Centre Berlin, and Charité University Medicine, Department of Rheumatology and Clinical Immunology, Berlin, Germany; Hospital for Special Surgery, Division of Pediatric Rheumatology, New York, New York; Connecticut Children’s Medical Center, Pediatric Rheumatology, Hartford, Connecticut; Tulsa Bone and Joint Associates, Tulsa, Oklahoma; Genentech, South San Francisco, California; University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Division of Rheumatology, Department of Pediatrics, PRCSG Coordinating Center, Cincinnati, Ohio, USA; National Referral Centre of Auto-Inflammatory Diseases, CEREMAIA, Centre Hospitalier Universitaire (CHU) de Bicere, Department of Pediatric Rheumatology, AP-HP, University of Paris Sud, Le Kremlin Bicêtre, France; University Hospital of Ioannina, Unit of Paediatric Rheumatology, Paediatric Clinic, Ioannina, Greece; Children’s Institute, Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo (HCFMUSP), Pediatric Rheumatology Unit, Sao Paulo, Brazil. The study was sponsored by F. Hoffmann-La Roche Ltd., which manufactures tocilizumab. Support for third-party writing assistance was provided by Sara Duggan, PhD, of ApotheCom and was funded by F. Hoffmann-La Roche Ltd. J. Wang is an employee of F. Hoffmann-La Roche Ltd. N. Ruperto is a consultant/speaker for F. Hoffmann-La Roche Ltd. E. Alexeeva is a consultant/speaker for F. Hoffmann-La Roche Ltd. K. Minden is a consultant/speaker or receives honoraria from F. Hoffmann-La Roche Ltd. I. Koné-Paut is a consultant to F. Hoffmann-La Roche Ltd. B. Porter-Brown is an employee of and owns stock in F. Hoffmann-La Roche Ltd. K. Bharucha owns stock in F. Hoffmann-La Roche Ltd. H.I. Brunner is a consultant/speaker or receives honoraria from F. Hoffmann-La Roche Ltd. F. De Benedetti is a consultant/speaker or receives honoraria from F. Hoffmann-La Roche Ltd. M. Pardeo, MD, IRCCS Ospedale Pediatrico Bambino Gesù, Division of Rheumatology; J. Wang, PhD, Roche Products Ltd.; N. Ruperto, MD, MPH, IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO; E. Alexeeva, MD, PhD, Professor, Federal State Autonomous Institution National Medical Research Center of Children’s Health of the Ministry of Health of the Russian Federation, Department of Rheumatology, and Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation, Department of Pediatrics and Pediatric Rheumatology; V. Chasnyk, MD, Professor, Saint-Petersburg State Pediatric Medical University, Department of Hospital Pediatrics; R. Schneider, MBBCh, Hospital for Sick Children, University of Toronto, Department of Pediatrics, Division of Rheumatology; G. Horneff, MD, Professor, Asklepios Klinik Sankt Augustin, Centre for General Pediatrics and Neonatology, Sankt Augustin, and University Hospital of Cologne; H.I. Huppertz, MD, Professor, Prof. Hess Children’s Hospital and Pediatric Intensive Care Medicine; K. Minden, MD, German Rheumatism Research Centre Berlin, and Charité University Medicine, Department of Rheumatology and Clinical Immunology; K. Onel, MD, Professor, Hospital for Special Surgery, Division of Pediatric Rheumatology; L. Zemel, MD, Connecticut Children’s Medical Center, Pediatric Rheumatology; A. Martin, MD, Tulsa Bone and Joint Associates; I. Koné-Paut, MD, National Referral Centre of Auto-Inflammatory Diseases, CEREMAIA, CHU de Bicere, Department of Pediatric Rheumatology, AP-HP, University of Paris Sud; A. Siamopoulou-Mavridou, MD, Professor, University Hospital of Ioannina, Unit of Paediatric Rheumatology, Paediatric Clinic; C.A. Silva, MD, PhD, Associate Professor, Children’s Institute, HCFMUSP, Pediatric Rheumatology Unit; B. Porter-Brown, MBBS, DPM, MFPM, Roche Products Ltd.; K.N. Bharucha, PhD, MD, Genentech (affiliation at time of the study); H.I. Brunner, MD, MSc, University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Division of Rheumatology, Department of Pediatrics, PRCSG Coordinating Center; F. De Benedetti, MD, PhD, IRCCS Ospedale Pediatrico Bambino Gesù, Division of Rheumatology. M. Pardeo and J. Wang contributed equally to the study. Address correspondence to Dr. F. De Benedetti, IRCCS Ospedale Pediatrico Bambino Gesù, Piazza S. Onofrio 4, 00165 Rome, Italy. E-mail: fabrizio.debenedetti@opbg.net. Full Release Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication December 19, 2018.
Hermine I. Brunner
From the Institute for Research and Health Care (IRCCS) Ospedale Pediatrico Bambino Gesù, Division of Rheumatology, Rome, Italy; Roche Products Ltd., Welwyn Garden City, UK; IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO, Genoa, Italy; Federal State Autonomous Institution National Medical Research Center of Children’s Health of the Ministry of Health of the Russian Federation, Department of Rheumatology, and Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation, Department of Pediatrics and Pediatric Rheumatology, Moscow; Saint-Petersburg State Pediatric Medical University, Department of Hospital Pediatrics, St. Petersburg, Russia; Hospital for Sick Children, University of Toronto, Department of Pediatrics, Division of Rheumatology, Toronto, Ontario, Canada; Asklepios Klinik Sankt Augustin, Centre for General Pediatrics and Neonatology, Sankt Augustin, and University Hospital of Cologne, Cologne; Prof. Hess Children’s Hospital and Pediatric Intensive Care Medicine, Bremen; German Rheumatism Research Centre Berlin, and Charité University Medicine, Department of Rheumatology and Clinical Immunology, Berlin, Germany; Hospital for Special Surgery, Division of Pediatric Rheumatology, New York, New York; Connecticut Children’s Medical Center, Pediatric Rheumatology, Hartford, Connecticut; Tulsa Bone and Joint Associates, Tulsa, Oklahoma; Genentech, South San Francisco, California; University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Division of Rheumatology, Department of Pediatrics, PRCSG Coordinating Center, Cincinnati, Ohio, USA; National Referral Centre of Auto-Inflammatory Diseases, CEREMAIA, Centre Hospitalier Universitaire (CHU) de Bicere, Department of Pediatric Rheumatology, AP-HP, University of Paris Sud, Le Kremlin Bicêtre, France; University Hospital of Ioannina, Unit of Paediatric Rheumatology, Paediatric Clinic, Ioannina, Greece; Children’s Institute, Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo (HCFMUSP), Pediatric Rheumatology Unit, Sao Paulo, Brazil. The study was sponsored by F. Hoffmann-La Roche Ltd., which manufactures tocilizumab. Support for third-party writing assistance was provided by Sara Duggan, PhD, of ApotheCom and was funded by F. Hoffmann-La Roche Ltd. J. Wang is an employee of F. Hoffmann-La Roche Ltd. N. Ruperto is a consultant/speaker for F. Hoffmann-La Roche Ltd. E. Alexeeva is a consultant/speaker for F. Hoffmann-La Roche Ltd. K. Minden is a consultant/speaker or receives honoraria from F. Hoffmann-La Roche Ltd. I. Koné-Paut is a consultant to F. Hoffmann-La Roche Ltd. B. Porter-Brown is an employee of and owns stock in F. Hoffmann-La Roche Ltd. K. Bharucha owns stock in F. Hoffmann-La Roche Ltd. H.I. Brunner is a consultant/speaker or receives honoraria from F. Hoffmann-La Roche Ltd. F. De Benedetti is a consultant/speaker or receives honoraria from F. Hoffmann-La Roche Ltd. M. Pardeo, MD, IRCCS Ospedale Pediatrico Bambino Gesù, Division of Rheumatology; J. Wang, PhD, Roche Products Ltd.; N. Ruperto, MD, MPH, IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO; E. Alexeeva, MD, PhD, Professor, Federal State Autonomous Institution National Medical Research Center of Children’s Health of the Ministry of Health of the Russian Federation, Department of Rheumatology, and Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation, Department of Pediatrics and Pediatric Rheumatology; V. Chasnyk, MD, Professor, Saint-Petersburg State Pediatric Medical University, Department of Hospital Pediatrics; R. Schneider, MBBCh, Hospital for Sick Children, University of Toronto, Department of Pediatrics, Division of Rheumatology; G. Horneff, MD, Professor, Asklepios Klinik Sankt Augustin, Centre for General Pediatrics and Neonatology, Sankt Augustin, and University Hospital of Cologne; H.I. Huppertz, MD, Professor, Prof. Hess Children’s Hospital and Pediatric Intensive Care Medicine; K. Minden, MD, German Rheumatism Research Centre Berlin, and Charité University Medicine, Department of Rheumatology and Clinical Immunology; K. Onel, MD, Professor, Hospital for Special Surgery, Division of Pediatric Rheumatology; L. Zemel, MD, Connecticut Children’s Medical Center, Pediatric Rheumatology; A. Martin, MD, Tulsa Bone and Joint Associates; I. Koné-Paut, MD, National Referral Centre of Auto-Inflammatory Diseases, CEREMAIA, CHU de Bicere, Department of Pediatric Rheumatology, AP-HP, University of Paris Sud; A. Siamopoulou-Mavridou, MD, Professor, University Hospital of Ioannina, Unit of Paediatric Rheumatology, Paediatric Clinic; C.A. Silva, MD, PhD, Associate Professor, Children’s Institute, HCFMUSP, Pediatric Rheumatology Unit; B. Porter-Brown, MBBS, DPM, MFPM, Roche Products Ltd.; K.N. Bharucha, PhD, MD, Genentech (affiliation at time of the study); H.I. Brunner, MD, MSc, University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Division of Rheumatology, Department of Pediatrics, PRCSG Coordinating Center; F. De Benedetti, MD, PhD, IRCCS Ospedale Pediatrico Bambino Gesù, Division of Rheumatology. M. Pardeo and J. Wang contributed equally to the study. Address correspondence to Dr. F. De Benedetti, IRCCS Ospedale Pediatrico Bambino Gesù, Piazza S. Onofrio 4, 00165 Rome, Italy. E-mail: fabrizio.debenedetti@opbg.net. Full Release Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication December 19, 2018.
Fabrizio De Benedetti
From the Institute for Research and Health Care (IRCCS) Ospedale Pediatrico Bambino Gesù, Division of Rheumatology, Rome, Italy; Roche Products Ltd., Welwyn Garden City, UK; IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO, Genoa, Italy; Federal State Autonomous Institution National Medical Research Center of Children’s Health of the Ministry of Health of the Russian Federation, Department of Rheumatology, and Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation, Department of Pediatrics and Pediatric Rheumatology, Moscow; Saint-Petersburg State Pediatric Medical University, Department of Hospital Pediatrics, St. Petersburg, Russia; Hospital for Sick Children, University of Toronto, Department of Pediatrics, Division of Rheumatology, Toronto, Ontario, Canada; Asklepios Klinik Sankt Augustin, Centre for General Pediatrics and Neonatology, Sankt Augustin, and University Hospital of Cologne, Cologne; Prof. Hess Children’s Hospital and Pediatric Intensive Care Medicine, Bremen; German Rheumatism Research Centre Berlin, and Charité University Medicine, Department of Rheumatology and Clinical Immunology, Berlin, Germany; Hospital for Special Surgery, Division of Pediatric Rheumatology, New York, New York; Connecticut Children’s Medical Center, Pediatric Rheumatology, Hartford, Connecticut; Tulsa Bone and Joint Associates, Tulsa, Oklahoma; Genentech, South San Francisco, California; University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Division of Rheumatology, Department of Pediatrics, PRCSG Coordinating Center, Cincinnati, Ohio, USA; National Referral Centre of Auto-Inflammatory Diseases, CEREMAIA, Centre Hospitalier Universitaire (CHU) de Bicere, Department of Pediatric Rheumatology, AP-HP, University of Paris Sud, Le Kremlin Bicêtre, France; University Hospital of Ioannina, Unit of Paediatric Rheumatology, Paediatric Clinic, Ioannina, Greece; Children’s Institute, Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo (HCFMUSP), Pediatric Rheumatology Unit, Sao Paulo, Brazil. The study was sponsored by F. Hoffmann-La Roche Ltd., which manufactures tocilizumab. Support for third-party writing assistance was provided by Sara Duggan, PhD, of ApotheCom and was funded by F. Hoffmann-La Roche Ltd. J. Wang is an employee of F. Hoffmann-La Roche Ltd. N. Ruperto is a consultant/speaker for F. Hoffmann-La Roche Ltd. E. Alexeeva is a consultant/speaker for F. Hoffmann-La Roche Ltd. K. Minden is a consultant/speaker or receives honoraria from F. Hoffmann-La Roche Ltd. I. Koné-Paut is a consultant to F. Hoffmann-La Roche Ltd. B. Porter-Brown is an employee of and owns stock in F. Hoffmann-La Roche Ltd. K. Bharucha owns stock in F. Hoffmann-La Roche Ltd. H.I. Brunner is a consultant/speaker or receives honoraria from F. Hoffmann-La Roche Ltd. F. De Benedetti is a consultant/speaker or receives honoraria from F. Hoffmann-La Roche Ltd. M. Pardeo, MD, IRCCS Ospedale Pediatrico Bambino Gesù, Division of Rheumatology; J. Wang, PhD, Roche Products Ltd.; N. Ruperto, MD, MPH, IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO; E. Alexeeva, MD, PhD, Professor, Federal State Autonomous Institution National Medical Research Center of Children’s Health of the Ministry of Health of the Russian Federation, Department of Rheumatology, and Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation, Department of Pediatrics and Pediatric Rheumatology; V. Chasnyk, MD, Professor, Saint-Petersburg State Pediatric Medical University, Department of Hospital Pediatrics; R. Schneider, MBBCh, Hospital for Sick Children, University of Toronto, Department of Pediatrics, Division of Rheumatology; G. Horneff, MD, Professor, Asklepios Klinik Sankt Augustin, Centre for General Pediatrics and Neonatology, Sankt Augustin, and University Hospital of Cologne; H.I. Huppertz, MD, Professor, Prof. Hess Children’s Hospital and Pediatric Intensive Care Medicine; K. Minden, MD, German Rheumatism Research Centre Berlin, and Charité University Medicine, Department of Rheumatology and Clinical Immunology; K. Onel, MD, Professor, Hospital for Special Surgery, Division of Pediatric Rheumatology; L. Zemel, MD, Connecticut Children’s Medical Center, Pediatric Rheumatology; A. Martin, MD, Tulsa Bone and Joint Associates; I. Koné-Paut, MD, National Referral Centre of Auto-Inflammatory Diseases, CEREMAIA, CHU de Bicere, Department of Pediatric Rheumatology, AP-HP, University of Paris Sud; A. Siamopoulou-Mavridou, MD, Professor, University Hospital of Ioannina, Unit of Paediatric Rheumatology, Paediatric Clinic; C.A. Silva, MD, PhD, Associate Professor, Children’s Institute, HCFMUSP, Pediatric Rheumatology Unit; B. Porter-Brown, MBBS, DPM, MFPM, Roche Products Ltd.; K.N. Bharucha, PhD, MD, Genentech (affiliation at time of the study); H.I. Brunner, MD, MSc, University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Division of Rheumatology, Department of Pediatrics, PRCSG Coordinating Center; F. De Benedetti, MD, PhD, IRCCS Ospedale Pediatrico Bambino Gesù, Division of Rheumatology. M. Pardeo and J. Wang contributed equally to the study. Address correspondence to Dr. F. De Benedetti, IRCCS Ospedale Pediatrico Bambino Gesù, Piazza S. Onofrio 4, 00165 Rome, Italy. E-mail: fabrizio.debenedetti@opbg.net. Full Release Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication December 19, 2018.
In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Neutropenia During Tocilizumab Treatment Is Not Associated with Infection Risk in Systemic or Polyarticular-course Juvenile Idiopathic Arthritis
Manuela Pardeo, Jianmei Wang, Nicolino Ruperto, Ekaterina Alexeeva, Vyacheslav Chasnyk, Rayfel Schneider, Gerd Horneff, Hans-Iko Huppertz, Kirsten Minden, Karen Onel, Lawrence Zemel, Alan Martin, Isabelle Koné-Paut, Antigoni Siamopoulou-Mavridou, Clovis A. Silva, Benjamin Porter-Brown, Kamal N. Bharucha, Hermine I. Brunner, Fabrizio De Benedetti
The Journal of Rheumatology Mar 2019, jrheum.180795; DOI: 10.3899/jrheum.180795
Neutropenia During Tocilizumab Treatment Is Not Associated with Infection Risk in Systemic or Polyarticular-course Juvenile Idiopathic Arthritis
Manuela Pardeo, Jianmei Wang, Nicolino Ruperto, Ekaterina Alexeeva, Vyacheslav Chasnyk, Rayfel Schneider, Gerd Horneff, Hans-Iko Huppertz, Kirsten Minden, Karen Onel, Lawrence Zemel, Alan Martin, Isabelle Koné-Paut, Antigoni Siamopoulou-Mavridou, Clovis A. Silva, Benjamin Porter-Brown, Kamal N. Bharucha, Hermine I. Brunner, Fabrizio De Benedetti
The Journal of Rheumatology Mar 2019, jrheum.180795; DOI: 10.3899/jrheum.180795