Pregnancy Outcomes in Couples with Males Exposed to Longterm Anti–tumor Necrosis Factor–α Inhibitor Therapies: A Prospective Study
Abstract
Objective To examine the pregnancy achievement and outcomes in couples in which men with spondyloarthritis (SpA) were exposed to tumor necrosis factor inhibitors (TNFi).
Methods Information about pregnancies involving fathers with SpA was prospectively collected by 6 Romanian rheumatology centers.
Results Twenty-seven patients achieved 33 pregnancies and fathered 30 healthy children. Three elective abortions (personal reasons) and no spontaneous abortions, preeclampsia/eclampsia, stillbirths, congenital malformations, or pathologies in the children were recorded. Five patients showed normospermia before and after longterm TNFi treatment.
Conclusion Pregnancy and child outcomes in male patients with SpA exposed to longterm TNFi therapy were reassuring.